Atf4 (activating transcription factor 4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Atf4 (activating transcription factor 4) Rattus norvegicus
Analyze
Symbol: Atf4
Name: activating transcription factor 4
RGD ID: 621863
Description: Enables DNA-binding transcription factor binding activity and general transcription initiation factor binding activity. Involved in several processes, including gamma-aminobutyric acid signaling pathway; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; and response to manganese-induced endoplasmic reticulum stress. Located in dendrite membrane. Biomarker of borna disease and pulmonary venoocclusive disease. Human ortholog(s) of this gene implicated in prostate carcinoma. Orthologous to human ATF4 (activating transcription factor 4); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Endoplasmic Reticulum-associated degradation pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor ATF-4; cAMP-dependent transcription factor ATF-4; cyclic AMP-dependent transcription factor ATF-4; rATF-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,684,681 - 113,686,739 (+)NCBIGRCr8
mRatBN7.27111,804,135 - 111,806,457 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,558,983 - 113,561,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,782,520 - 115,784,577 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,751,882 - 115,753,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,480,723 - 121,482,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,468,275 - 121,470,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,537,718 - 118,538,994NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,571,947 - 118,573,223NCBI
Cytogenetic Map7q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4Ratborna disease  IEP 32733622protein:increased expression:cerebellumRGD 
Atf4Ratprostate carcinoma treatmentISOATF4 (Homo sapiens)13504680 RGD 
Atf4Ratprostatic hypertrophy  ISOAtf4 (Mus musculus)13504679 RGD 
Atf4Ratpulmonary venoocclusive disease  IEP 38549370protein:increased expression:lungRGD 
Atf4RatZika fever  ISOAtf4 (Mus musculus)32733625mRNA:increased expression:brainRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4Ratadenylosuccinase lyase deficiency  ISOATF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Adenylosuccinate lyase deficiencyClinVarPMID:28492532
Atf4RatRubinstein-Taybi syndrome  ISOATF4 (Homo sapiens)8554872ClinVar Annotator: match by term: Rubinstein-Taybi syndrome 2ClinVarPMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4RatHypoxia  ISOATF4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14604972
Atf4Ratinvasive ductal carcinoma  ISOATF4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14604972
Atf4RatNecrosis  ISOATF4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14604972
Atf4RatSpinal Cord Injuries  ISOATF4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29793971
Atf4Ratsteatotic liver disease  ISOATF4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27664470

1 to 20 of 675 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4Rat(+)-catechin increases expressionISOATF4 (Homo sapiens)6480464Catechin results in increased expression of ATF4 mRNACTDPMID:15465739
Atf4Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of ATF4 mRNA]CTDPMID:31150632
Atf4Rat(-)-citrinin increases expressionISOATF4 (Homo sapiens)6480464Citrinin results in increased expression of ATF4 mRNACTDPMID:21844328
Atf4Rat(-)-epigallocatechin 3-gallate multiple interactionsISOATF4 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of ATF4 mRNACTDPMID:22079256
Atf4Rat(R)-lipoic acid multiple interactionsISOAtf4 (Mus musculus)6480464Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 mRNA] and Thioctic Acid inhibits the reaction [arsenic trioxide results in increased expression of ATF4 protein]CTDPMID:23892647
Atf4Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [cadmium acetate results in increased expression of ATF4 protein]CTDPMID:30605698
Atf4Rat(S)-amphetamine increases expressionEXP 6480464Dextroamphetamine results in increased expression of ATF4 mRNACTDPMID:18305237
Atf4Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionISOAtf4 (Mus musculus)6480464o and p'-DDT results in increased expression of ATF4 mRNACTDPMID:24096037
Atf4Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expressionEXP 6480464o and p'-DDT results in increased expression of ATF4 mRNACTDPMID:24096037
Atf4Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464p-coumaric acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of ATF4 protein]CTDPMID:29879413
Atf4Rat1,2-dimethylhydrazine increases expressionISOAtf4 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ATF4 mRNACTDPMID:22206623
Atf4Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of ATF4 proteinCTDPMID:29879413
Atf4Rat1,4-dithiothreitol increases expressionISOATF4 (Homo sapiens)6480464Dithiothreitol results in increased expression of ATF4 mRNACTDPMID:27226639
Atf4Rat1,4-dithiothreitol increases expressionISOAtf4 (Mus musculus)6480464Dithiothreitol results in increased expression of ATF4 mRNACTDPMID:27226639
Atf4Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of ATF4 mRNACTDPMID:20551477
Atf4Rat1-naphthyl isothiocyanate multiple interactionsISOATF4 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of ATF4 mRNACTDPMID:27344345
Atf4Rat17alpha-ethynylestradiol multiple interactionsISOAtf4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of ATF4 mRNA and fulvestrant inhibits the reaction [Ethinyl Estradiol results in increased expression of ATF4 mRNA]CTDPMID:16467188 and PMID:17942748
Atf4Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ATF4 mRNACTDPMID:16174780 more ...
Atf4Rat17alpha-ethynylestradiol increases expressionISOAtf4 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ATF4 mRNACTDPMID:16174780 more ...
Atf4Rat17beta-estradiol increases expressionISOAtf4 (Mus musculus)6480464Estradiol results in increased expression of ATF4 mRNACTDPMID:25210133 and PMID:39298647

1 to 20 of 675 rows

Biological Process
1 to 20 of 137 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4Ratbone mineralization involved_inISSUniProtKB:Q065071600115GO_REF:0000024UniProtGO_REF:0000024
Atf4Ratbone mineralization involved_inIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratbone mineralization involved_inISOAtf4 (Mus musculus)1624291 PMID:15109498RGDPMID:15109498
Atf4Ratcellular response to amino acid starvation involved_inISSUniProtKB:Q065071600115GO_REF:0000024UniProtGO_REF:0000024
Atf4Ratcellular response to amino acid starvation involved_inISOAtf4 (Mus musculus)1624291 PMID:11106749 more ...RGDPMID:11106749 more ...
Atf4Ratcellular response to amino acid starvation involved_inIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcellular response to amino acid starvation involved_inISSUniProtKB:Q6ZWX61600115GO_REF:0000024UniProtGO_REF:0000024
Atf4Ratcellular response to glucose starvation involved_inISOATF4 (Homo sapiens)1624291 PMID:22915762RGDPMID:22915762
Atf4Ratcellular response to glucose starvation involved_inIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcellular response to hypoxia  IEP 13464322oxygen-glucose deprivationRGD 
Atf4Ratcellular response to leucine starvation involved_inISOATF4 (Homo sapiens)1624291 PMID:17267404RGDPMID:17267404
Atf4Ratcellular response to leucine starvation involved_inIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcellular response to leucine starvation involved_inIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcellular response to leucine starvation involved_inISOAtf4 (Mus musculus)1624291 PMID:17267404RGDPMID:17267404
Atf4Ratcellular response to oxidative stress involved_inISSUniProtKB:Q065071600115GO_REF:0000024UniProtGO_REF:0000024
Atf4Ratcellular response to oxidative stress involved_inIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcellular response to oxidative stress involved_inISOATF4 (Homo sapiens)1624291 PMID:21113145 and PMID:23392669RGDPMID:21113145 and PMID:23392669
Atf4Ratcellular response to oxidative stress involved_inISOAtf4 (Mus musculus)1624291 PMID:12667446RGDPMID:12667446
Atf4Ratcellular response to oxidative stress involved_inIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcellular response to oxidative stress involved_inIMP 10047168PMID:23392669ParkinsonsUK-UCL 
1 to 20 of 137 rows

Cellular Component
1 to 20 of 51 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4RatATF1-ATF4 transcription factor complex part_ofISOATF4 (Homo sapiens)1624291 PMID:12871976RGDPMID:12871976
Atf4RatATF1-ATF4 transcription factor complex part_ofIBAMGI:88096 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atf4RatATF1-ATF4 transcription factor complex part_ofISOAtf4 (Mus musculus)1624291 PMID:12871976RGDPMID:12871976
Atf4RatATF1-ATF4 transcription factor complex part_ofIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatATF1-ATF4 transcription factor complex part_ofIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatATF4-CREB1 transcription factor complex part_ofISOAtf4 (Mus musculus)1624291 PMID:12871976RGDPMID:12871976
Atf4RatATF4-CREB1 transcription factor complex part_ofIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatATF4-CREB1 transcription factor complex part_ofIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatATF4-CREB1 transcription factor complex part_ofIBAMGI:88096 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atf4RatATF4-CREB1 transcription factor complex part_ofISOATF4 (Homo sapiens)1624291 PMID:12871976RGDPMID:12871976
Atf4Ratcentrosome located_inISOATF4 (Homo sapiens)1624291 PMID:20873783RGDPMID:20873783
Atf4Ratcentrosome located_inIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcentrosome located_inIEAUniProtKB-SubCell:SL-00481600115GO_REF:0000044UniProtGO_REF:0000044
Atf4RatCHOP-ATF4 complex part_ofISOATF4 (Homo sapiens)1624291UniProtKB:P35638 more ...RGDPMID:11478948 and PMID:18940792
Atf4RatCHOP-ATF4 complex part_ofIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcytoplasm located_inISOAtf4 (Mus musculus)1624291 PMID:15013631 more ...RGDPMID:15013631 more ...
Atf4Ratcytoplasm located_inIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Atf4Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Atf4Ratcytoplasm located_inIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 51 rows

Molecular Function
1 to 20 of 54 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4RatcAMP response element binding protein binding enablesISSUniProtKB:Q065071600115GO_REF:0000024UniProtGO_REF:0000024
Atf4RatcAMP response element binding protein binding enablesIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatcAMP response element binding protein binding enablesISOAtf4 (Mus musculus)1624291 PMID:23624402RGDPMID:23624402
Atf4RatDNA binding enablesISSUniProtKB:P188481600115GO_REF:0000024UniProtGO_REF:0000024
Atf4RatDNA binding enablesISOAtf4 (Mus musculus)1624291MGI:2679336 PMID:16751105RGDPMID:16751105
Atf4RatDNA binding enablesIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatDNA binding enablesIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Atf4RatDNA binding enablesISOATF4 (Homo sapiens)1624291 PMID:15788408 more ...RGDPMID:15788408 more ...
Atf4RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOAtf4 (Mus musculus)1624291 PMID:15788408RGDPMID:15788408
Atf4RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIBAMGI:88096 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atf4RatDNA-binding transcription factor activity enablesISSUniProtKB:Q065071600115GO_REF:0000024UniProtGO_REF:0000024
Atf4RatDNA-binding transcription factor activity enablesIEAUniProtKB:P18848 and ensembl:ENSP000005018631600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatDNA-binding transcription factor activity enablesIEAInterPro:IPR004827 and InterPro:IPR0463471600115GO_REF:0000002InterProGO_REF:0000002
Atf4RatDNA-binding transcription factor activity enablesIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
Atf4RatDNA-binding transcription factor activity enablesISOAtf4 (Mus musculus)1624291 PMID:12667446 more ...RGDPMID:12667446 more ...
Atf4RatDNA-binding transcription factor activity enablesISOATF4 (Homo sapiens)1624291 PMID:11960987 more ...RGDPMID:11960987 more ...
Atf4RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOATF4 (Homo sapiens)1624291 PMID:11478948 and PMID:12871976RGDPMID:11478948 and PMID:12871976
Atf4RatDNA-binding transcription factor activity, RNA polymerase II-specific contributes_toIEAUniProtKB:Q06507 and ensembl:ENSMUSP000001052341600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 54 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4Ratendoplasmic reticulum stress - the unfolded protein response pathway  ISOATF4 (Homo sapiens)10450872 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Atf4RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141
Atf4Ratgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912
Atf4Ratlong term potentiation  IEA 6907045 KEGGrno:04720
Atf4Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
Atf4Ratneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722
Atf4Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215

1 to 20 of 24 rows
#
Reference Title
Reference Citation
1. Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells. Cho YM, etal., Exp Mol Med. 2009 Jun 30;41(6):440-52. doi: 10.3858/emm.2009.41.6.049.
2. Enhanced expression of C/EBP homologous protein (CHOP) precedes degeneration of fibrocytes in the lateral wall after acute cochlear mitochondrial dysfunction induced by 3-nitropropionic acid. Fujinami Y, etal., Neurochem Int. 2010 Feb;56(3):487-94. doi: 10.1016/j.neuint.2009.12.008. Epub 2009 Dec 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. STAMP2 increases oxidative stress and is critical for prostate cancer. Jin Y, etal., EMBO Mol Med. 2015 Mar;7(3):315-31. doi: 10.15252/emmm.201404181.
6. ATF4-Induced Metabolic Reprograming Is a Synthetic Vulnerability of the p62-Deficient Tumor Stroma. Linares JF, etal., Cell Metab. 2017 Dec 5;26(6):817-829.e6. doi: 10.1016/j.cmet.2017.09.001. Epub 2017 Oct 5.
7. Comparison of Human and Experimental Pulmonary Veno-Occlusive Disease. Manaud G, etal., Am J Respir Cell Mol Biol. 2020 Jul;63(1):118-131. doi: 10.1165/rcmb.2019-0015OC.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. The metabotropic GABAB receptor directly interacts with the activating transcription factor 4. Nehring RB, etal., J Biol Chem 2000 Nov 10;275(45):35185-91.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. ATF4 protects against neuronal death in cellular Parkinson's disease models by maintaining levels of parkin. Sun X, etal., J Neurosci. 2013 Feb 6;33(6):2398-407. doi: 10.1523/JNEUROSCI.2292-12.2013.
16. ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
17. Targeted disruption of ATF4 discloses its essential role in the formation of eye lens fibres. Tanaka T, etal., Genes Cells 1998 Dec;3(12):801-10.
18. Effects of ATF4 on PGC1a expression in brown adipose tissue and metabolic responses to cold stress. Wang C, etal., Metabolism. 2013 Feb;62(2):282-9. doi: 10.1016/j.metabol.2012.07.017. Epub 2012 Sep 11.
19. The impact of the unfolded protein response on human disease. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
20. Endoplasmic reticulum stress and neurodegeneration in rats neonatally infected with borna disease virus. Williams BL and Lipkin WI, J Virol. 2006 Sep;80(17):8613-26. doi: 10.1128/JVI.00836-06.
1 to 20 of 24 rows
PMID:8506317   PMID:10580117   PMID:10602480   PMID:11106749   PMID:11274184   PMID:11478948   PMID:11916968   PMID:11960987   PMID:12749859   PMID:12871976   PMID:14729979   PMID:15013631  
PMID:15277680   PMID:15724149   PMID:15775988   PMID:15788408   PMID:15911876   PMID:16445384   PMID:16682973   PMID:16751105   PMID:18305237   PMID:18617696   PMID:18654882   PMID:18940792  
PMID:19017641   PMID:19061639   PMID:19232401   PMID:19726676   PMID:20873783   PMID:21068199   PMID:21113145   PMID:21159964   PMID:21436843   PMID:21768648   PMID:21821103   PMID:21984568  
PMID:22095285   PMID:22507839   PMID:22915762   PMID:22952236   PMID:22974638   PMID:23663782   PMID:23686245   PMID:24136195   PMID:24939851   PMID:25012492   PMID:26174742   PMID:27233218  
PMID:27484784   PMID:27812542   PMID:27841340   PMID:28188284   PMID:29875265   PMID:31416289   PMID:31787756   PMID:32304741   PMID:35315506   PMID:35403324   PMID:35531910   PMID:35574856  
PMID:36928813   PMID:38879481  



Atf4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,684,681 - 113,686,739 (+)NCBIGRCr8
mRatBN7.27111,804,135 - 111,806,457 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7113,558,983 - 113,561,040 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,782,520 - 115,784,577 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,751,882 - 115,753,939 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07121,480,723 - 121,482,781 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07121,468,275 - 121,470,587 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47118,537,718 - 118,538,994NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17118,571,947 - 118,573,223NCBI
Cytogenetic Map7q34NCBI
ATF4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382239,520,559 - 39,522,686 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2239,519,695 - 39,522,686 (+)EnsemblGRCh38hg38GRCh38
GRCh372239,916,564 - 39,918,691 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362238,246,515 - 38,248,637 (+)NCBINCBI36Build 36hg18NCBI36
Build 342238,241,068 - 38,243,191NCBI
Celera2223,718,625 - 23,720,747 (+)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2222,881,158 - 22,883,280 (+)NCBIHuRef
CHM1_12239,875,308 - 39,877,431 (+)NCBICHM1_1
T2T-CHM13v2.02239,985,692 - 39,993,317 (+)NCBIT2T-CHM13v2.0
Atf4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391580,139,385 - 80,141,746 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1580,139,385 - 80,141,742 (+)EnsemblGRCm39 Ensembl
GRCm381580,255,184 - 80,257,545 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1580,255,184 - 80,257,541 (+)EnsemblGRCm38mm10GRCm38
MGSCv371580,085,614 - 80,087,971 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361580,082,756 - 80,084,759 (+)NCBIMGSCv36mm8
Celera1582,372,526 - 82,374,883 (+)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.85NCBI
Atf4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541325,406,589 - 25,412,218 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541325,406,589 - 25,408,727 (+)NCBIChiLan1.0ChiLan1.0
ATF4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22349,368,664 - 49,369,904 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12252,058,755 - 52,061,257 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02220,426,743 - 20,428,892 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12238,246,337 - 38,249,333 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2238,248,094 - 38,249,249 (+)Ensemblpanpan1.1panPan2
ATF4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11025,528,880 - 25,531,018 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1025,528,874 - 25,530,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1025,464,741 - 25,466,879 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01026,280,612 - 26,282,756 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1026,280,619 - 26,282,738 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11025,995,219 - 25,997,329 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01026,314,765 - 26,316,875 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01026,490,223 - 26,492,367 (-)NCBIUU_Cfam_GSD_1.0
Atf4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,104,066 - 9,105,487 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,110,634 - 2,115,996 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,114,478 - 2,115,969 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATF4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl58,742,967 - 8,745,368 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.158,742,964 - 8,745,752 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,042,584 - 6,044,651 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATF4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11922,092,046 - 22,094,184 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1922,091,667 - 22,095,230 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045103,557,595 - 103,561,018 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atf4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247528,822,740 - 8,825,032 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247528,822,955 - 8,825,019 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Atf4
6 total Variants

Predicted Target Of
Summary Value
Count of predictions:153
Count of miRNA genes:124
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000065304
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300179Kidm5Kidney mass QTL 53.51kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)743747012135012528Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7111182207135012528Rat
1331728Bp214Blood pressure QTL 2142.825arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)780221299124373579Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7102297359133492884Rat
2298475Eau6Experimental allergic uveoretinitis QTL 60.0029uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)784257275129257275Rat
71114Niddm14Non-insulin dependent diabetes mellitus QTL 144.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)784257275129257275Rat
1357336Gluco6Glucose level QTL 63.4blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)794811326116294265Rat
1357338Stl17Serum triglyceride level QTL 173.23blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)769736356112729554Rat
631687Hcas1Hepatocarcinoma susceptibility QTL 13.90.001liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)791412594129807172Rat
70159Bp61Blood pressure QTL 610.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7103146217116738842Rat

1 to 10 of 35 rows
RH127863  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,806,076 - 111,806,285 (+)MAPPERmRatBN7.2
Rnor_6.07121,482,401 - 121,482,609NCBIRnor6.0
Rnor_5.07121,470,216 - 121,470,424UniSTSRnor5.0
RGSC_v3.47118,538,623 - 118,538,831UniSTSRGSC3.4
RH 3.4 Map7861.0UniSTS
Cytogenetic Map7q34UniSTS
PMC19934P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,805,777 - 111,806,254 (+)MAPPERmRatBN7.2
Rnor_6.07121,482,102 - 121,482,578NCBIRnor6.0
Rnor_5.07121,469,917 - 121,470,393UniSTSRnor5.0
RGSC_v3.47118,538,324 - 118,538,800UniSTSRGSC3.4
Cytogenetic Map7q34UniSTS
UniSTS:274176  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,804,444 - 111,805,676 (+)MAPPERmRatBN7.2
Rnor_6.07121,480,770 - 121,482,000NCBIRnor6.0
Rnor_5.07121,468,585 - 121,469,815UniSTSRnor5.0
RGSC_v3.47118,536,992 - 118,538,222UniSTSRGSC3.4
Cytogenetic Map7q34UniSTS
Atf4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27111,806,080 - 111,806,329 (+)MAPPERmRatBN7.2
Rnor_6.07121,482,405 - 121,482,653NCBIRnor6.0
Rnor_5.07121,470,220 - 121,470,468UniSTSRnor5.0
Cytogenetic Map7q34UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_024403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039079942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF252627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210065 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214151 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214217 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215912 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232693 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000065304   ⟹   ENSRNOP00000060302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7111,804,183 - 111,806,446 (+)Ensembl
Rnor_6.0 Ensembl7121,480,723 - 121,482,772 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092302
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7121,480,735 - 121,481,478 (+)Ensembl
RefSeq Acc Id: NM_024403   ⟹   NP_077379
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,684,681 - 113,686,739 (+)NCBI
mRatBN7.27111,804,398 - 111,806,457 (+)NCBI
Rnor_6.07121,480,723 - 121,482,781 (+)NCBI
Rnor_5.07121,468,275 - 121,470,587 (+)NCBI
RGSC_v3.47118,537,718 - 118,538,994 (+)RGD
Sequence:
RefSeq Acc Id: XM_039079942   ⟹   XP_038935870
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87113,685,575 - 113,686,730 (+)NCBI
mRatBN7.27111,804,135 - 111,806,448 (+)NCBI
Protein RefSeqs NP_077379 (Get FASTA)   NCBI Sequence Viewer  
  XP_038935870 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG31732 (Get FASTA)   NCBI Sequence Viewer  
  AAI58589 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060302
  ENSRNOP00000060302.1
GenBank Protein Q9ES19 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077379   ⟸   NM_024403
- UniProtKB: Q9ES19 (UniProtKB/Swiss-Prot),   B0BMW3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060302   ⟸   ENSRNOT00000065304
RefSeq Acc Id: XP_038935870   ⟸   XM_039079942
- Peptide Label: isoform X1
bZIP

Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES19-F1-model_v2 AlphaFold Q9ES19 1-347 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695496
Promoter ID:EPDNEW_R6021
Type:multiple initiation site
Name:Atf4_1
Description:activating transcription factor 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07121,480,721 - 121,480,781EPDNEW


1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-32706 BioCyc
Ensembl Genes ENSRNOG00000017801 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000065304 ENTREZGENE
  ENSRNOT00000065304.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:9098368 IMAGE-MGC_LOAD
InterPro bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
KEGG Report rno:79255 UniProtKB/Swiss-Prot
MGC_CLONE MGC:187368 IMAGE-MGC_LOAD
NCBI Gene 79255 ENTREZGENE
PANTHER ACTIVATING TRANSCRIPTION FACTOR ATF 4/5 UniProtKB/Swiss-Prot
  CYCLIC AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
PhenoGen Atf4 PhenoGen
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017801 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57959 UniProtKB/Swiss-Prot
UniProt ATF4_RAT UniProtKB/Swiss-Prot
  B0BMW3 ENTREZGENE, UniProtKB/TrEMBL
  Q9ES19 ENTREZGENE
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-06-05 Atf4  activating transcription factor 4  Atf4  activating transcription factor 4 (tax-responsive enhancer element B67)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Atf4  activating transcription factor 4 (tax-responsive enhancer element B67)  Atf4  activating transcription factor 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Atf4  activating transcription factor 4    activating transcription factor ATF-4  Name updated 1299863 APPROVED
2002-08-07 Atf4  activating transcription factor ATF-4      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_product member of the cAMP response element-binding protein/ATF family 631878