Dhcr7 (7-dehydrocholesterol reductase) - Rat Genome Database

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Gene: Dhcr7 (7-dehydrocholesterol reductase) Rattus norvegicus
Analyze
Symbol: Dhcr7
Name: 7-dehydrocholesterol reductase
RGD ID: 621769
Description: Enables 7-dehydrocholesterol reductase activity. Involved in cholesterol biosynthetic process and regulation of cholesterol biosynthetic process. Predicted to be located in endoplasmic reticulum and nuclear outer membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Behcet's disease and Smith-Lemli-Opitz syndrome. Orthologous to human DHCR7 (7-dehydrocholesterol reductase); PARTICIPATES IN cholesterol biosynthetic pathway; steroid biosynthetic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 7-DHC reductase; cholesterol-5,6-epoxide hydrolase subunit DHCR7; MGC93039; sterol Delta(7)-reductase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,444,434 - 208,460,408 (+)NCBIGRCr8
mRatBN7.21199,015,081 - 199,031,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,015,081 - 199,031,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1207,394,648 - 207,410,602 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01214,476,501 - 214,492,466 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,150,670 - 207,166,635 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,018,916 - 217,034,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,018,916 - 217,034,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,874,935 - 223,890,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,245,562 - 204,258,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11204,399,014 - 204,412,366 (+)NCBI
Celera1196,577,886 - 196,593,821 (+)NCBICelera
Cytogenetic Map1q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Original Reference(s)
Dhcr7RatBehcet's disease  ISODHCR7 (Homo sapiens)401901083associated with uveitis and DNA:SNP:CDS:rs12785878 (human)RGD 
Dhcr7RatMuscle Hypotonia  ISODhcr7 (Mus musculus)734884 RGD 
Dhcr7RatSmith-Lemli-Opitz syndrome  ISODHCR7 (Homo sapiens)1600899DNA:insertionRGD 
Dhcr7RatSmith-Lemli-Opitz syndrome  ISODhcr7 (Mus musculus)734884 RGD 
Dhcr7RatVitamin D Deficiency  ISODHCR7 (Homo sapiens)401901168DNA:SNP:CDS:rs12785878 (human)RGD 
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Dhcr7Rat3-methylglutaconic aciduria type 7b  ISODHCR7 (Homo sapiens)8554872ClinVar Annotator: match by term: 3-methylglutaconic aciduria and type VIIBClinVarPMID:28492532
Dhcr7Ratcerebral folate receptor alpha deficiency  ISODHCR7 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodegeneration due to cerebral folate transport deficiencyClinVarPMID:28492532
Dhcr7Ratgenetic disease  ISODHCR7 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10405455 more ...
Dhcr7Rathepatoblastoma  ISODHCR7 (Homo sapiens)8554872ClinVar Annotator: match by term: HepatoblastomaClinVarPMID:12270273 more ...
Dhcr7Ratintellectual disability  ISODHCR7 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Dhcr7Ratmicrocephaly  ISODHCR7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10602371 more ...
Dhcr7Ratprimary microcephaly  ISODHCR7 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary microcephalyClinVarPMID:10677299 more ...
Dhcr7RatSmith-Lemli-Opitz syndrome  ISODHCR7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10405455 more ...
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Original Reference(s)
Dhcr7Ratacute promyelocytic leukemia  ISODHCR7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32929351
Dhcr7RatAnimal Disease Models  ISODHCR7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29698737
Dhcr7Ratautistic disorder  ISODHCR7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14659996
Dhcr7Ratliver cirrhosis  ISODHCR7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24381012
Dhcr7RatMetabolic Bone Diseases  ISODHCR7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24381012
Dhcr7RatSmith-Lemli-Opitz syndrome  ISODHCR7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11254748 more ...
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Original Reference(s)
Dhcr7RatSmith-Lemli-Opitz syndrome  ISSDhcr7 (Mus musculus)13592920OMIM:270400MouseDO 
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Original Reference(s)
Dhcr7RatSmith-Lemli-Opitz syndrome  ISODHCR7 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Dhcr7Rat(+)-catechin multiple interactionsISODHCR7 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of DHCR7 mRNACTDPMID:24763279
Dhcr7Rat(-)-epigallocatechin 3-gallate increases expressionISODHCR7 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of DHCR7 mRNACTDPMID:32512070
Dhcr7Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of DHCR7 mRNACTDPMID:17984292
Dhcr7Rat1,2-dichloroethane decreases expressionISODhcr7 (Mus musculus)6480464ethylene dichloride results in decreased expression of DHCR7 mRNACTDPMID:28960355
Dhcr7Rat1,2-dimethylhydrazine decreases expressionISODhcr7 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of DHCR7 mRNACTDPMID:22206623
Dhcr7Rat1-naphthyl isothiocyanate multiple interactionsISODHCR7 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of DHCR7 mRNACTDPMID:27344345
Dhcr7Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of DHCR7 mRNACTDPMID:30723492
Dhcr7Rat17alpha-ethynylestradiol increases expressionISODhcr7 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of DHCR7 mRNACTDPMID:17942748
Dhcr7Rat17alpha-ethynylestradiol multiple interactionsISODHCR7 (Homo sapiens)6480464[Ethinyl Estradiol co-treated with Cholic Acids] affects the expression of DHCR7 mRNACTDPMID:27344345
Dhcr7Rat17alpha-ethynylestradiol multiple interactionsISODhcr7 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHCR7 mRNACTDPMID:17942748
Dhcr7Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of DHCR7 mRNACTDPMID:16174780
Dhcr7Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of DHCR7 mRNACTDPMID:15901920
Dhcr7Rat17beta-estradiol increases expressionISODHCR7 (Homo sapiens)6480464Estradiol results in increased expression of DHCR7 mRNACTDPMID:19167446 and PMID:31614463
Dhcr7Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of DHCR7 mRNACTDPMID:32145629
Dhcr7Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISODhcr7 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:28433925
Dhcr7Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISODHCR7 (Homo sapiens)64804642 more ...CTDPMID:31173147
Dhcr7Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISODhcr7 (Mus musculus)64804642 more ...CTDPMID:30294300
Dhcr7Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISODhcr7 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with 2 more ...CTDPMID:17942748 and PMID:28433925
Dhcr7Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISODhcr7 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of DHCR7 mRNACTDPMID:21570461 and PMID:26377647
Dhcr7Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of DHCR7 mRNACTDPMID:21215274 more ...

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Biological Process
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Original Reference(s)
Dhcr7Ratblood vessel development acts_upstream_of_or_withinISODhcr7 (Mus musculus)1624291MGI:2387406 PMID:15005800RGDPMID:15005800
Dhcr7Ratcholesterol biosynthetic process  IMP 2316918 RGD 
Dhcr7Ratcholesterol biosynthetic process  IDA 632010 RGD 
Dhcr7Ratcholesterol biosynthetic process  TAS 625561 RGD 
Dhcr7Ratcholesterol biosynthetic process  ICGO:00475982316916 RGD 
Dhcr7Ratcholesterol biosynthetic process involved_inIEAUniProtKB:Q9UBM7 and ensembl:ENSP000003477171600115GO_REF:0000107EnsemblGO_REF:0000107
Dhcr7Ratcholesterol biosynthetic process involved_inIEAUniProtKB-KW:KW-01521600115GO_REF:0000043UniProtGO_REF:0000043
Dhcr7Ratcholesterol biosynthetic process involved_inIEAUniPathway:UPA000631600115GO_REF:0000041UniProtGO_REF:0000041
Dhcr7Ratcholesterol biosynthetic process involved_inIBAPANTHER:PTN001082975 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dhcr7Ratcholesterol biosynthetic process involved_inIEAUniRule:UR0019337621600115GO_REF:0000104UniProtGO_REF:0000104
Dhcr7Ratcholesterol biosynthetic process involved_inISODHCR7 (Homo sapiens)1624291 PMID:9465114RGDPMID:9465114
Dhcr7Ratcholesterol biosynthetic process via lathosterol involved_inISODHCR7 (Homo sapiens)1624291 PMID:38297129 and PMID:38297130RGDPMID:38297129 and PMID:38297130
Dhcr7Ratcholesterol biosynthetic process via lathosterol involved_inIEAUniProtKB:Q9UBM7 and ensembl:ENSP000003477171600115GO_REF:0000107EnsemblGO_REF:0000107
Dhcr7Ratcholesterol metabolic process involved_inIEAUniProtKB-KW:KW-01531600115GO_REF:0000043UniProtGO_REF:0000043
Dhcr7Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Dhcr7Ratlung development acts_upstream_of_or_withinISODhcr7 (Mus musculus)1624291MGI:2387406 PMID:15005800RGDPMID:15005800
Dhcr7Ratlung epithelial cell differentiation acts_upstream_of_or_withinISODhcr7 (Mus musculus)1624291MGI:2387406 PMID:15005800RGDPMID:15005800
Dhcr7Ratmulticellular organism growth acts_upstream_of_or_withinISODhcr7 (Mus musculus)1624291MGI:2387406 PMID:15005800RGDPMID:15005800
Dhcr7Ratpositive regulation of ferroptosis involved_inISODHCR7 (Homo sapiens)1624291 PMID:38297129 and PMID:38297130RGDPMID:38297129 and PMID:38297130
Dhcr7Ratpositive regulation of ferroptosis involved_inIEAUniProtKB:Q9UBM7 and ensembl:ENSP000003477171600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Dhcr7Ratendoplasmic reticulum located_inISODHCR7 (Homo sapiens)1624291 PMID:9878250RGDGO_REF:0000052 and PMID:9878250
Dhcr7Ratendoplasmic reticulum located_inIEAUniProtKB:Q9UBM7 and ensembl:ENSP000003477171600115GO_REF:0000107EnsemblGO_REF:0000107
Dhcr7Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Dhcr7Ratendoplasmic reticulum located_inIEAUniProtKB:A0A024R5F7 and ensembl:ENSP000003477171600115GO_REF:0000107EnsemblGO_REF:0000107
Dhcr7Ratendoplasmic reticulum membrane is_active_inIBAPANTHER:PTN000479179 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dhcr7Ratendoplasmic reticulum membrane located_inIEAUniRule:UR0019337621600115GO_REF:0000104UniProtGO_REF:0000104
Dhcr7Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Dhcr7Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Dhcr7Ratmembrane located_inIEAInterPro:IPR0011711600115GO_REF:0000002InterProGO_REF:0000002
Dhcr7Ratnuclear outer membrane located_inIEAUniProtKB:Q9UBM7 and ensembl:ENSP000003477171600115GO_REF:0000107EnsemblGO_REF:0000107
Dhcr7Ratnuclear outer membrane located_inISODHCR7 (Homo sapiens)1624291 PMID:9878250RGDPMID:9878250
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Molecular Function
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Original Reference(s)
Dhcr7Rat7-dehydrocholesterol reductase activity  IMP 2316918 RGD 
Dhcr7Rat7-dehydrocholesterol reductase activity  TAS 625561 RGD 
Dhcr7Rat7-dehydrocholesterol reductase activity  IMP 2316916 RGD 
Dhcr7Rat7-dehydrocholesterol reductase activity enablesIEAEC:1.3.1.211600115GO_REF:0000003UniProtGO_REF:0000003
Dhcr7Rat7-dehydrocholesterol reductase activity enablesISODhcr7 (Mus musculus)1624291 PMID:11792727RGDPMID:11792727
Dhcr7Rat7-dehydrocholesterol reductase activity enablesIEARHEA:239841600115GO_REF:0000116RHEAGO_REF:0000116
Dhcr7Rat7-dehydrocholesterol reductase activity enablesIEAUniProtKB:Q9UBM7 and ensembl:ENSP000003477171600115GO_REF:0000107EnsemblGO_REF:0000107
Dhcr7Rat7-dehydrocholesterol reductase activity enablesISODHCR7 (Homo sapiens)1624291 PMID:38297129 more ...RGDPMID:38297129 more ...
Dhcr7Rat7-dehydrocholesterol reductase activity enablesIBAMGI:1298378 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dhcr7Ratcholesterol-5,6-oxide hydrolase activity enablesISSUniProtKB:Q9UBM71600115GO_REF:0000024UniProtGO_REF:0000024
Dhcr7Ratcholesterol-5,6-oxide hydrolase activity enablesIEAUniProtKB:Q9UBM7 and ensembl:ENSP000003477171600115GO_REF:0000107EnsemblGO_REF:0000107
Dhcr7Ratcholesterol-5,6-oxide hydrolase activity enablesIEARHEA:11964 and RHEA:151131600115GO_REF:0000116RHEAGO_REF:0000116
Dhcr7Ratcholesterol-5,6-oxide hydrolase activity enablesISODHCR7 (Homo sapiens)1624291 PMID:20615952RGDPMID:20615952
Dhcr7Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Dhcr7RatNADP binding enablesISSUniProtKB:G4SW861600115GO_REF:0000024UniProtGO_REF:0000024
Dhcr7Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Dhcr7Ratoxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor enablesIEAInterPro:IPR001171 and InterPro:IPR0180831600115GO_REF:0000002InterProGO_REF:0000002
Dhcr7Ratprotein binding enablesISODHCR7 (Homo sapiens)1624291UniProtKB:Q15392 more ...RGDPMID:25637936 and PMID:32694168
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RGD Manual Annotations


  
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Original Reference(s)
Dhcr7Ratcholesterol biosynthetic pathway   IMP 2316918 RGD 
Dhcr7Ratcholesterol biosynthetic pathway   ISODHCR7 (Homo sapiens)2316868 RGD 
Dhcr7Ratcholesterol biosynthetic pathway   ISODHCR7 (Homo sapiens)2316857 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
Dhcr7Ratsteroid biosynthetic pathway  IEA 6907045 KEGGrno:00100

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#
Reference Title
Reference Citation
1. Cholesterol biosynthesis from lanosterol. Molecular cloning, tissue distribution, expression, chromosomal localization, and regulation of rat 7-dehydrocholesterol reductase, a Smith-Lemli-Opitz syndrome-related protein. Bae SH, etal., J Biol Chem 1999 May 21;274(21):14624-31.
2. Polymorphisms in genetics of vitamin D metabolism confer susceptibility to ocular Behçet disease in a Chinese Han population. Fang J, etal., Am J Ophthalmol. 2014 Feb;157(2):488-494.e6. doi: 10.1016/j.ajo.2013.10.010. Epub 2013 Nov 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Disorders of cholesterol biosynthesis: prototypic metabolic malformation syndromes. Herman GE Hum Mol Genet. 2003 Apr 1;12 Spec No 1:R75-88.
6. The human lamin B receptor/sterol reductase multigene family. Holmer L, etal., Genomics 1998 Dec 15;54(3):469-76.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Association of circulating 25-hydroxyvitamin D levels with hypertension and blood pressure values in Korean adults: A Mendelian randomization study on a subset of the Korea National Health and Nutrition Survey 2011-2012 population. Kwak SY, etal., Nutr Res Pract. 2019 Dec;13(6):498-508. doi: 10.4162/nrp.2019.13.6.498. Epub 2019 Aug 13.
9. Structure and alternative splicing of the rat 7-dehydrocholesterol reductase gene. Lee JN, etal., Biochim Biophys Acta 2002 Jun 7;1576(1-2):148-56.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Evidence for requirement of NADPH-cytochrome P450 oxidoreductase in the microsomal NADPH-sterol Delta7-reductase system. Nishino H and Ishibashi T, Arch Biochem Biophys. 2000 Feb 15;374(2):293-8.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Regulation of rat hepatic 3beta-hydroxysterol delta7-reductase: substrate specificity, competitive and non-competitive inhibition, and phosphorylation/dephosphorylation. Shefer S, etal., J Lipid Res. 1998 Dec;39(12):2471-6.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Biochemical, phenotypic and neurophysiological characterization of a genetic mouse model of RSH/Smith--Lemli--Opitz syndrome. Wassif CA, etal., Hum Mol Genet 2001 Mar 15;10(6):555-64.
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PMID:9465114   PMID:11792727   PMID:15005800   PMID:15489334   PMID:19946888   PMID:37329988  



Dhcr7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81208,444,434 - 208,460,408 (+)NCBIGRCr8
mRatBN7.21199,015,081 - 199,031,055 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1199,015,081 - 199,031,055 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1207,394,648 - 207,410,602 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01214,476,501 - 214,492,466 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01207,150,670 - 207,166,635 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01217,018,916 - 217,034,890 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1217,018,916 - 217,034,904 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01223,874,935 - 223,890,913 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41204,245,562 - 204,258,913 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11204,399,014 - 204,412,366 (+)NCBI
Celera1196,577,886 - 196,593,821 (+)NCBICelera
Cytogenetic Map1q42NCBI
DHCR7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381171,427,287 - 71,449,043 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1171,428,193 - 71,452,868 (-)EnsemblGRCh38hg38GRCh38
GRCh371171,138,333 - 71,160,089 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361170,823,105 - 70,837,125 (-)NCBINCBI36Build 36hg18NCBI36
Build 341170,823,110 - 70,837,047NCBI
Celera1168,438,984 - 68,453,003 (-)NCBICelera
Cytogenetic Map11q13.4NCBI
HuRef1167,439,049 - 67,453,070 (-)NCBIHuRef
CHM1_11171,029,428 - 71,043,448 (-)NCBICHM1_1
T2T-CHM13v2.01171,354,234 - 71,375,999 (-)NCBIT2T-CHM13v2.0
Dhcr7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397143,376,827 - 143,402,147 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7143,376,882 - 143,402,147 (+)EnsemblGRCm39 Ensembl
GRCm387143,823,167 - 143,848,410 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7143,823,145 - 143,848,410 (+)EnsemblGRCm38mm10GRCm38
MGSCv377151,009,072 - 151,034,315 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367143,632,557 - 143,657,800 (+)NCBIMGSCv36mm8
Celera7143,579,742 - 143,604,212 (+)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.33NCBI
Dhcr7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542215,119,173 - 15,136,771 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542215,119,155 - 15,136,771 (+)NCBIChiLan1.0ChiLan1.0
DHCR7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2972,320,577 - 72,334,547 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11173,363,320 - 73,376,738 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01166,450,230 - 66,464,214 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11169,721,741 - 69,735,715 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1169,721,741 - 69,735,715 (-)Ensemblpanpan1.1panPan2
DHCR7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11847,257,750 - 47,277,436 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1847,261,730 - 47,274,236 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1845,862,457 - 45,882,527 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01847,935,184 - 47,955,313 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1847,938,180 - 47,955,305 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11847,376,200 - 47,396,229 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01846,962,021 - 46,982,089 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01847,708,851 - 47,728,938 (+)NCBIUU_Cfam_GSD_1.0
LOC101971285
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049473,490,627 - 3,493,336 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367941,432,379 - 1,468,966 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DHCR7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl22,377,416 - 2,391,447 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.122,377,352 - 2,391,846 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22851,404 - 864,968 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DHCR7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.113,243,263 - 3,257,332 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl13,243,313 - 3,257,487 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038100,430,412 - 100,444,448 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dhcr7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476716,118,052 - 16,132,834 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476716,118,157 - 16,132,225 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Dhcr7
93 total Variants

Predicted Target Of
Summary Value
Count of predictions:118
Count of miRNA genes:89
Interacting mature miRNAs:106
Transcripts:ENSRNOT00000028195
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 93 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat

1 to 10 of 93 rows
RH128054  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21199,030,690 - 199,030,900 (+)MAPPERmRatBN7.2
Rnor_6.01217,034,526 - 217,034,735NCBIRnor6.0
Rnor_5.01223,890,549 - 223,890,758UniSTSRnor5.0
RGSC_v3.41204,258,549 - 204,258,758UniSTSRGSC3.4
Celera1196,593,457 - 196,593,666UniSTS
Cytogenetic Map1q41UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 18 of 18 rows
RefSeq Transcripts NM_022389 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230893 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230894 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039089500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272737 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272738 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272739 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB016800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC094001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF071500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF272393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF279892 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 18 of 18 rows

Ensembl Acc Id: ENSRNOT00000028195   ⟹   ENSRNOP00000028194
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,015,081 - 199,031,055 (+)Ensembl
Rnor_6.0 Ensembl1217,018,916 - 217,034,890 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078979   ⟹   ENSRNOP00000071939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1199,017,279 - 199,031,055 (+)Ensembl
Rnor_6.0 Ensembl1217,019,051 - 217,034,904 (+)Ensembl
RefSeq Acc Id: NM_022389   ⟹   NP_071784
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,434 - 208,460,408 (+)NCBI
mRatBN7.21199,015,081 - 199,031,055 (+)NCBI
Rnor_6.01217,018,916 - 217,034,890 (+)NCBI
Rnor_5.01223,874,935 - 223,890,913 (+)NCBI
RGSC_v3.41204,245,562 - 204,258,913 (+)RGD
Celera1196,577,886 - 196,593,821 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230893   ⟹   XP_006230955
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,546 - 208,460,408 (+)NCBI
mRatBN7.21199,015,133 - 199,031,055 (+)NCBI
Rnor_6.01217,019,017 - 217,034,890 (+)NCBI
Rnor_5.01223,874,935 - 223,890,913 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006230894   ⟹   XP_006230956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,566 - 208,460,408 (+)NCBI
mRatBN7.21199,015,234 - 199,031,055 (+)NCBI
Rnor_6.01217,019,041 - 217,034,890 (+)NCBI
Rnor_5.01223,874,935 - 223,890,913 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039089500   ⟹   XP_038945428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,564 - 208,460,408 (+)NCBI
mRatBN7.21199,015,188 - 199,031,055 (+)NCBI
RefSeq Acc Id: XM_063272737   ⟹   XP_063128807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,505 - 208,460,408 (+)NCBI
RefSeq Acc Id: XM_063272738   ⟹   XP_063128808
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,953 - 208,460,408 (+)NCBI
RefSeq Acc Id: XM_063272739   ⟹   XP_063128809
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81208,444,951 - 208,460,408 (+)NCBI
RefSeq Acc Id: NP_071784   ⟸   NM_022389
- UniProtKB: Q9Z2Z8 (UniProtKB/Swiss-Prot),   A6HYE0 (UniProtKB/TrEMBL),   A0A8L2R4U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230955   ⟸   XM_006230893
- Peptide Label: isoform X1
- UniProtKB: Q9Z2Z8 (UniProtKB/Swiss-Prot),   A6HYE0 (UniProtKB/TrEMBL),   A0A8L2R4U0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230956   ⟸   XM_006230894
- Peptide Label: isoform X1
- UniProtKB: Q9Z2Z8 (UniProtKB/Swiss-Prot),   A6HYE0 (UniProtKB/TrEMBL),   A0A8L2R4U0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028194   ⟸   ENSRNOT00000028195
Ensembl Acc Id: ENSRNOP00000071939   ⟸   ENSRNOT00000078979

Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z2Z8-F1-model_v2 AlphaFold Q9Z2Z8 1-471 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690582
Promoter ID:EPDNEW_R1105
Type:initiation region
Name:Dhcr7_1
Description:7-dehydrocholesterol reductase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01217,019,083 - 217,019,143EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56855 BioCyc
BioCyc Pathway PWY66-4 [cholesterol biosynthesis III (via desmosterol)] BioCyc
BioCyc Pathway Image PWY66-4 BioCyc
Ensembl Genes ENSRNOG00000020776 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000028195 ENTREZGENE
  ENSRNOT00000028195.6 UniProtKB/Swiss-Prot
  ENSRNOT00000078979 ENTREZGENE
Gene3D-CATH 1.20.120.1630 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109221 IMAGE-MGC_LOAD
InterPro Ergosterol_biosynth_ERG4_ERG24 UniProtKB/Swiss-Prot
  Sterol_reductase_CS UniProtKB/Swiss-Prot
KEGG Report rno:64191 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93039 IMAGE-MGC_LOAD
NCBI Gene 64191 ENTREZGENE
PANTHER 7-DEHYDROCHOLESTEROL REDUCTASE UniProtKB/Swiss-Prot
  DELTA(14)-STEROL REDUCTASE UniProtKB/Swiss-Prot
Pfam ERG4_ERG24 UniProtKB/Swiss-Prot
PhenoGen Dhcr7 PhenoGen
PROSITE STEROL_REDUCT_1 UniProtKB/Swiss-Prot
  STEROL_REDUCT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020776 RatGTEx
UniProt A0A8L2R4U0 ENTREZGENE, UniProtKB/TrEMBL
  A6HYE0 ENTREZGENE, UniProtKB/TrEMBL
  A6HYE4_RAT UniProtKB/TrEMBL
  DHCR7_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Dhcr7  7-dehydrocholesterol reductase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Dhcr7  7-dehydrocholesterol reductase      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_disease human homolog involved in Smith-Lemli-Opitz syndrome 632010
gene_expression expressed in liver, kidney and brain 632010
gene_protein 471 amino acid; 54 kDa 632010