Gsr (glutathione-disulfide reductase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Gsr (glutathione-disulfide reductase) Rattus norvegicus
Analyze
Symbol: Gsr
Name: glutathione-disulfide reductase
RGD ID: 621747
Description: Enables several functions, including glutathione binding activity; glutathione-disulfide reductase (NADPH) activity; and nucleotide binding activity. Involved in several processes, including response to iron(III) ion; response to ischemia; and response to vitamin A. Predicted to be located in external side of plasma membrane. Predicted to be active in cytosol and mitochondrion. Used to study cataract and transient cerebral ischemia. Biomarker of several diseases, including acute kidney failure (multiple); artery disease (multiple); hemorrhagic cystitis; myoglobinuria; and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 10 and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase); PARTICIPATES IN 2-hydroxyglutaric aciduria pathway; glutamic acid/glutamate metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (+)-catechin; (+)-schisandrin B; (+)-sesamin.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione reductase; glutathione reductase, mitochondrial; GR; GRase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,185,574 - 65,228,742 (-)NCBIGRCr8
mRatBN7.21658,482,209 - 58,525,256 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,482,505 - 58,525,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,820,015 - 63,862,474 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,233,692 - 67,276,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,454,254 - 62,496,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,197,617 - 62,239,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,197,617 - 62,241,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,859,601 - 61,901,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,255,562 - 62,298,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11662,255,636 - 62,298,530 (-)NCBI
Celera1656,518,556 - 56,560,956 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 69 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRatacute kidney failure  IEP 7257559glycerol-inducedRGD 
GsrRatacute kidney failure  ISORGD:7322227257585protein:decreased activity:kidney:RGD 
GsrRatacute kidney tubular necrosis  ISORGD:7322227257555 RGD 
GsrRatacute kidney tubular necrosis  IEP 7257573protein:decreased activity:renal cortex:RGD 
GsrRatAcute Lung Injury  IEP 7257562 RGD 
GsrRatacute lymphoblastic leukemia  ISORGD:73222111059506 RGD 
GsrRatacute myeloid leukemia  ISORGD:73222111059506 RGD 
GsrRatalcohol-induced mental disorder treatmentIEP 10401897 RGD 
GsrRatAlzheimer's disease  ISORGD:73222110401827protein:decreased expression:bloodRGD 
GsrRatAlzheimer's disease treatmentISORGD:73222210401857 RGD 
GsrRatAlzheimer's disease treatmentIEP 10401849 RGD 
GsrRatAlzheimer's disease  ISORGD:73222110401847mRNA:increased expression:hippocampusRGD 
GsrRatArsenic Poisoning  IEP 10401880 RGD 
GsrRatbeta thalassemia  ISORGD:73222111052141protein:decreased activity:erythrocyte:RGD 
GsrRatCadmium Poisoning treatmentIEP 10401881 RGD 
GsrRatCardiac Fibrosis treatmentIEP 401793732 RGD 
GsrRatCardiomegaly treatmentIEP 401793732 RGD 
GsrRatcataract treatmentIDA 10401885 RGD 
GsrRatcataract  ISORGD:7322211600697 RGD 
GsrRatChemical and Drug Induced Liver Injury  IEP 7257532mRNA, protein:increased expression:liverRGD 
1 to 20 of 69 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRatcongenital nonspherocytic hemolytic anemia 10  ISORGD:7322218554872ClinVar Annotator: match by term: GSR-related condition | ClinVar Annotator: match by term: Hemolytic anemia more ...ClinVarPMID:17185460|PMID:25741868|PMID:28492532|PMID:35361806|PMID:435643|PMID:947404
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRatamyotrophic lateral sclerosis  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:16681429
GsrRatanemia  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:5984971
GsrRatChemical and Drug Induced Liver Injury  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:25226513|PMID:28069987
GsrRatcontact dermatitis  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
GsrRatEdema  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:19874808
GsrRatExperimental Diabetes Mellitus  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:20620209
GsrRathemolytic anemia  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:13931269
GsrRathyperthyroidism  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:19914224
GsrRathypoglycemia  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:20620209
GsrRatneurodegenerative disease  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:15964507
GsrRatParkinsonism  ISORGD:73222111554173CTD Direct Evidence: therapeuticCTDPMID:22721943
GsrRatProtein Deficiency  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:15865262
GsrRatUreteral Calculi  ISORGD:73222111554173CTD Direct Evidence: marker/mechanismCTDPMID:24360074
1 to 13 of 13 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRatcongenital nonspherocytic hemolytic anemia 10  ISORGD:7322217240710 OMIM 

1 to 20 of 1239 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRat(+)-beta-thujone multiple interactionsISORGD:7322216480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated more ...CTDPMID:38000518
GsrRat(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [Isoproterenol results in decreased activity of GSR protein]CTDPMID:23261676
GsrRat(+)-schisandrin B multiple interactionsISORGD:7322226480464Buthionine Sulfoximine inhibits the reaction [schizandrin B results in increased activity of GSR protein]CTDPMID:17119269
GsrRat(+)-schisandrin B increases activityEXP 6480464schizandrin B analog results in increased activity of GSR protein; schizandrin B results in increased more ...CTDPMID:17119269|PMID:21328628
GsrRat(+)-schisandrin B multiple interactionsEXP 6480464Buthionine Sulfoximine inhibits the reaction [schizandrin B results in increased activity of GSR protein]CTDPMID:17119269
GsrRat(+)-schisandrin B increases activityISORGD:7322226480464schizandrin B results in increased activity of GSR proteinCTDPMID:17119269
GsrRat(+)-sesamin increases activityEXP 6480464sesamin results in increased activity of GSR proteinCTDPMID:19835851
GsrRat(+)-taxifolin multiple interactionsEXP 6480464Fluvastatin promotes the reaction [taxifolin inhibits the reaction [bisphenol A results in decreased expression of more ...CTDPMID:33882723|PMID:35465754
GsrRat(+)-trans-(S)-allethrin decreases activityISORGD:7322216480464bioallethrin results in decreased activity of GSR proteinCTDPMID:32097678
GsrRat(+/-)-Aegeline multiple interactionsISORGD:7322226480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with more ...CTDPMID:28843594
GsrRat(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[epigallocatechin gallate co-treated with coenzyme Q10] inhibits the reaction [Cisplatin results in decreased activity of more ...CTDPMID:20020850|PMID:33393703|PMID:33754881
GsrRat(-)-epigallocatechin 3-gallate increases activityISORGD:7322216480464epigallocatechin gallate results in increased activity of GSR proteinCTDPMID:26187476
GsrRat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:7322226480464epigallocatechin gallate inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results more ...CTDPMID:25528115|PMID:31350662
GsrRat(-)-epigallocatechin 3-gallate decreases expressionISORGD:7322226480464epigallocatechin gallate results in decreased expression of GSR mRNACTDPMID:25528115
GsrRat(1->4)-beta-D-glucan multiple interactionsISORGD:7322226480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GSR mRNACTDPMID:36331819
GsrRat(aminooxy)acetic acid multiple interactionsEXP 6480464Aminooxyacetic Acid inhibits the reaction [N-acetyl-S-pentachloro-1,3-butadienylcysteine results in decreased activity of GSR protein]CTDPMID:2360207
GsrRat(E)-cinnamyl alcohol increases expressionISORGD:7322216480464cinnamyl alcohol results in increased expression of GSR mRNACTDPMID:20566472
GsrRat(R)-camphor multiple interactionsISORGD:7322216480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated more ...CTDPMID:38000518
GsrRat(R)-linalyl acetate multiple interactionsISORGD:7322216480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated more ...CTDPMID:38000518
GsrRat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [aroclor 1260 results in decreased expression of GSR protein]; Thioctic more ...CTDPMID:19699728|PMID:22623521|PMID:27581792|PMID:38342389

1 to 20 of 1239 rows

Biological Process
1 to 17 of 17 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRatcell redox homeostasis involved_inIBACGD:CAL0000194377|PANTHER:PTN002448883|PomBase:SPBC17A3.07|SGD:S000006012|WB:WBGene00008117|ZFIN:ZDB-GENE-050522-116|dictyBase:DDB_G02727541600115GO_REF:0000033GO_CentralGO_REF:0000033
GsrRatcell redox homeostasis involved_inIEAInterPro:IPR0469521600115GO_REF:0000002InterProGO_REF:0000002
GsrRatcellular oxidant detoxification involved_inIEAGO:00043621600115GO_REF:0000108GOCGO_REF:0000108
GsrRatcellular response to oxidative stress involved_inIBACGD:CAL0000194377|PANTHER:PTN002448883|SGD:S000006012|UniProtKB:C8VUN91600115GO_REF:0000033GO_CentralGO_REF:0000033
GsrRatglutathione metabolic process  IDA 1625133 RGD 
GsrRatglutathione metabolic process involved_inIBAPANTHER:PTN002448883|PomBase:SPBC17A3.07|RGD:621747|SGD:S000006012|UniProtKB:C8VUN9|WB:WBGene00008117|dictyBase:DDB_G02727541600115GO_REF:0000033GO_CentralGO_REF:0000033
GsrRatglutathione metabolic process involved_inIEAInterPro:IPR0063221600115GO_REF:0000002InterProGO_REF:0000002
GsrRatresponse to activity  IEP 11059509 RGD 
GsrRatresponse to auditory stimulus  ISORGD:89549831624291 RGDRGD:11556227|RGD:150520179
GsrRatresponse to cadmium ion  IEP 11059510 RGD 
GsrRatresponse to ethanol  IEP 7257531 RGD 
GsrRatresponse to iron(III) ion  IEP 11059508 RGD 
GsrRatresponse to ischemia  IEP 11059511 RGD 
GsrRatresponse to nicotine  IEP 7257535 RGD 
GsrRatresponse to oxidative stress  IEP 11059507 RGD 
GsrRatresponse to vitamin A  IEP 7257533 RGD 
GsrRatspermatogenesis  IMP 632952 RGD 
1 to 17 of 17 rows

Cellular Component
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
GsrRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
GsrRatcytosol located_inIEAUniProtKB:P00390|ensembl:ENSP000002211301600115GO_REF:0000107EnsemblGO_REF:0000107
GsrRatcytosol is_active_inIBAPANTHER:PTN002448883|PomBase:SPBC17A3.07|SGD:S000006012|UniProtKB:C8VUN9|UniProtKB:P00390|WB:WBGene000081171600115GO_REF:0000033GO_CentralGO_REF:0000033
GsrRatcytosol located_inTAS 1600115Reactome:R-RNO-2408514ReactomeReactome:R-RNO-2408514
GsrRatcytosol located_inISORGD:732221|UniProtKB:P00390-11624291 RGDGO_REF:0000052
GsrRatcytosol located_inIEAUniProtKB:V9HW90|ensembl:ENSP000002211301600115GO_REF:0000107EnsemblGO_REF:0000107
GsrRatexternal side of plasma membrane located_inIEAUniProtKB:P47791|ensembl:ENSMUSP000000339921600115GO_REF:0000107EnsemblGO_REF:0000107
GsrRatexternal side of plasma membrane located_inISORGD:7322221624291 PMID:24029230RGDPMID:24029230
GsrRatmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
GsrRatmitochondrion is_active_inIBAPANTHER:PTN000530560|PomBase:SPBC17A3.07|UniProtKB:C8VUN9|WB:WBGene000081171600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 11 of 11 rows

Molecular Function
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRatflavin adenine dinucleotide binding  IDA 1625133 RGD 
GsrRatflavin adenine dinucleotide binding enablesIBAPANTHER:PTN002448883|RGD:621747|UniProtKB:C8VUN9|UniProtKB:P067151600115GO_REF:0000033GO_CentralGO_REF:0000033
GsrRatflavin adenine dinucleotide binding enablesIEAInterPro:IPR006322|InterPro:IPR0469521600115GO_REF:0000002InterProGO_REF:0000002
GsrRatglutathione binding  IDA 1625133 RGD 
GsrRatglutathione-disulfide reductase (NADPH) activity  TAS 632952 RGD 
GsrRatglutathione-disulfide reductase (NADPH) activity enablesIEARHEA:117401600115GO_REF:0000116RHEAGO_REF:0000116
GsrRatglutathione-disulfide reductase (NADPH) activity enablesIBACGD:CAL0000194377|MGI:95804|PANTHER:PTN002448883|PomBase:SPBC17A3.07|RGD:621747|SGD:S000006012|UniProtKB:P06715|WB:WBGene00008117|dictyBase:DDB_G02727541600115GO_REF:0000033GO_CentralGO_REF:0000033
GsrRatglutathione-disulfide reductase (NADPH) activity enablesISORGD:7322221624291 PMID:1235912, PMID:204065, PMID:2139228, PMID:7323947, PMID:8417789RGDPMID:1235912|PMID:204065|PMID:2139228|PMID:7323947|PMID:8417789
GsrRatglutathione-disulfide reductase (NADPH) activity enablesIEAInterPro:IPR0063221600115GO_REF:0000002InterProGO_REF:0000002
GsrRatglutathione-disulfide reductase (NADPH) activity enablesIEAUniProtKB:P47791|ensembl:ENSMUSP000000339921600115GO_REF:0000107EnsemblGO_REF:0000107
GsrRatglutathione-disulfide reductase (NADPH) activity enablesIDA 10047267PMID:21930213CACAO 
GsrRatglutathione-disulfide reductase (NADPH) activity enablesIEAEC:1.8.1.71600115GO_REF:0000003UniProtGO_REF:0000003
GsrRatglutathione-disulfide reductase (NADPH) activity  IDA 1625133 RGD 
GsrRatidentical protein binding  IPIRGD:6217471625133homodimerizationRGD 
GsrRatNADP binding  IDA 1625133 RGD 
GsrRatNADP binding enablesIEAInterPro:IPR0063221600115GO_REF:0000002InterProGO_REF:0000002
GsrRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
GsrRatoxidoreductase activity enablesIEAInterPro:IPR001100|InterPro:IPR0237531600115GO_REF:0000002InterProGO_REF:0000002
GsrRatoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
GsrRatoxidoreductase activity enablesIEAInterPro:IPR0237531600115GO_REF:0000002InterProGO_REF:0000002
1 to 20 of 21 rows

Imported Annotations - SMPDB

1 to 9 of 9 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRat2-hydroxyglutaric aciduria pathway  ISORGD:73222110402751 SMPDBSMP:00136
GsrRatglutamic acid/glutamate metabolic pathway  ISORGD:73222110402751 SMPDBSMP:00072
GsrRatglutathione metabolic pathway  ISORGD:73222110402751 SMPDBSMP:00015
GsrRatglutathione synthase deficiency pathway  ISORGD:73222110402751 SMPDBSMP:00337
GsrRatglutathione synthase deficiency pathway  ISORGD:73222110402751 SMPDBSMP:00143
GsrRatglutathionuria disease pathway  ISORGD:73222110402751 SMPDBSMP:00501
GsrRathomocarnosinosis pathway  ISORGD:73222110402751 SMPDBSMP:00385
GsrRatsuccinic semialdehyde dehydrogenase deficiency pathway  ISORGD:73222110402751 SMPDBSMP:00243
GsrRatsuccinic semialdehyde dehydrogenase deficiency pathway  ISORGD:73222110402751 SMPDBSMP:00567
1 to 9 of 9 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
GsrRatglutathione metabolic pathway  IEA 6907045 KEGGrno:00480

1 to 20 of 86 rows
#
Reference Title
Reference Citation
1. Protective effect of Satureja montana extract on cyclophosphamide-induced testicular injury in rats. Abd El Tawab AM, etal., Chem Biol Interact. 2014 Nov 11;224C:196-205. doi: 10.1016/j.cbi.2014.11.001.
2. Protective effect of aminoguanidine against oxidative stress and bladder injury in cyclophosphamide-induced hemorrhagic cystitis in rat. Abraham P, etal., Cell Biochem Funct. 2009 Jan;27(1):56-62. doi: 10.1002/cbf.1534.
3. Purification of rat kidney glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, and glutathione reductase enzymes using 2',5'-ADP Sepharose 4B affinity in a single chromatography step. Adem S and Ciftci M, Protein Expr Purif. 2012 Jan;81(1):1-4. doi: 10.1016/j.pep.2011.08.031. Epub 2011 Sep 10.
4. The expression of key oxidative stress-handling genes in different brain regions in Alzheimer's disease. Aksenov MY, etal., J Mol Neurosci. 1998 Oct;11(2):151-64.
5. Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis. Ali N, etal., Mol Cell Biochem. 2014 Jan;385(1-2):215-23. doi: 10.1007/s11010-013-1830-4. Epub 2013 Oct 24.
6. Hyperbaric oxygen preconditioning protects rats against CNS oxygen toxicity. Arieli Y, etal., Respir Physiol Neurobiol. 2014 Jun 15;197:29-35. doi: 10.1016/j.resp.2014.03.006. Epub 2014 Mar 24.
7. Hepatoprotective effect of satureja khuzestanica essential oil and vitamin e in experimental hyperthyroid rats: evidence for role of antioxidant effect. Assaei R, etal., Iran J Med Sci. 2014 Sep;39(5):459-66.
8. Reactive oxygen species and phosphatidylserine externalization in murine sickle red cells. Banerjee T and Kuypers FA, Br J Haematol. 2004 Feb;124(3):391-402.
9. The effect of a minor constituent of essential oil from Citrus aurantium: the role of beta-myrcene in preventing peptic ulcer disease. Bonamin F, etal., Chem Biol Interact. 2014 Apr 5;212:11-9. doi: 10.1016/j.cbi.2014.01.009. Epub 2014 Jan 27.
10. Impact of long term Fe(3)(+) toxicity on expression of glutathione system in rat liver. Budak H, etal., Environ Toxicol Pharmacol. 2014 Jan;37(1):365-70. doi: 10.1016/j.etap.2013.12.007. Epub 2013 Dec 22.
11. Antioxidant capacity responsible for a hypocholesterolemia is independent of dietary cholesterol in adult rats fed rice protein. Cai J, etal., Gene. 2014 Jan 1;533(1):57-66. doi: 10.1016/j.gene.2013.09.124. Epub 2013 Oct 10.
12. Purification and characterization of the flavoenzyme glutathione reductase from rat liver. Carlberg I and Mannervik B, J Biol Chem. 1975 Jul 25;250(14):5475-80.
13. Cardiac energy metabolism and oxidative stress biomarkers in diabetic rat treated with resveratrol. Carolo dos Santos K, etal., PLoS One. 2014 Jul 22;9(7):e102775. doi: 10.1371/journal.pone.0102775. eCollection 2014.
14. Lipid peroxidation and antioxidant enzyme activities in vascular and Alzheimer dementias. Casado A, etal., Neurochem Res. 2008 Mar;33(3):450-8. Epub 2007 Aug 25.
15. Non-haem iron-mediated oxidative stress in haemoglobin E beta-thalassaemia. Chakraborty I, etal., Ann Acad Med Singapore. 2010 Jan;39(1):13-6.
16. Reversal of experimental myoglobinuric acute renal failure in rats by quercetin, a bioflavonoid. Chander V, etal., Pharmacology. 2005 Jan;73(1):49-56. Epub 2004 Sep 27.
17. Inadequate cytoplasmic antioxidant enzymes response contributes to the oxidative stress in human hypertension. Chaves FJ, etal., Am J Hypertens. 2007 Jan;20(1):62-9.
18. Low glutathione reductase and peroxidase activity in age-related macular degeneration. Cohen SM, etal., Br J Ophthalmol. 1994 Oct;78(10):791-4.
19. Parameters of antioxidative defense in type 2 diabetic patients with cardiovascular complications. Colak E, etal., Ann Med. 2005;37(8):613-20.
20. Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease. Cruz-Aguado R, etal., Restor Neurol Neurosci. 2000;17(4):217-221.
1 to 20 of 86 rows
PMID:204065   PMID:1235912   PMID:2139228   PMID:7323947   PMID:8417789   PMID:12516874   PMID:12967637   PMID:14651853   PMID:16189290   PMID:17382203   PMID:18614015   PMID:19056867  
PMID:23376485   PMID:23533145   PMID:24029230   PMID:26316444   PMID:34800366   PMID:34825649  



Gsr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81665,185,574 - 65,228,742 (-)NCBIGRCr8
mRatBN7.21658,482,209 - 58,525,256 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1658,482,505 - 58,525,661 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1663,820,015 - 63,862,474 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01667,233,692 - 67,276,139 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01662,454,254 - 62,496,705 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01662,197,617 - 62,239,987 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1662,197,617 - 62,241,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01661,859,601 - 61,901,971 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41662,255,562 - 62,298,458 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11662,255,636 - 62,298,530 (-)NCBI
Celera1656,518,556 - 56,560,956 (-)NCBICelera
Cytogenetic Map16q12.3NCBI
GSR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38830,678,066 - 30,727,846 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl830,678,066 - 30,727,846 (-)EnsemblGRCh38hg38GRCh38
GRCh37830,535,583 - 30,585,363 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36830,655,977 - 30,704,985 (-)NCBINCBI36Build 36hg18NCBI36
Build 34830,655,976 - 30,704,985NCBI
Celera829,494,968 - 29,543,967 (-)NCBICelera
Cytogenetic Map8p12NCBI
HuRef829,080,197 - 29,130,251 (-)NCBIHuRef
CHM1_1830,737,741 - 30,787,638 (-)NCBICHM1_1
T2T-CHM13v2.0830,957,535 - 31,007,300 (-)NCBIT2T-CHM13v2.0
Gsr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39834,143,266 - 34,188,190 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl834,142,551 - 34,188,191 (+)EnsemblGRCm39 Ensembl
GRCm38833,653,238 - 33,698,162 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl833,652,523 - 33,698,163 (+)EnsemblGRCm38mm10GRCm38
MGSCv37834,763,710 - 34,808,634 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36835,119,173 - 35,164,097 (+)NCBIMGSCv36mm8
MGSCv36832,569,577 - 32,614,657 (+)NCBIMGSCv36mm8
Celera836,289,529 - 36,337,457 (+)NCBICelera
Cytogenetic Map8A4NCBI
cM Map820.69NCBI
Gsr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554637,131,364 - 7,153,583 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554637,130,459 - 7,153,631 (-)NCBIChiLan1.0ChiLan1.0
GSR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2749,249,871 - 49,299,566 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1824,965,772 - 25,015,466 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0829,990,543 - 30,040,157 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1827,180,294 - 27,229,557 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl827,180,300 - 27,229,557 (-)Ensemblpanpan1.1panPan2
GSR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11633,633,949 - 33,680,411 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1633,633,968 - 33,679,752 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1634,093,319 - 34,142,803 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01635,660,075 - 35,709,366 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1635,659,426 - 35,709,550 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11633,758,663 - 33,808,143 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01634,330,564 - 34,379,803 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01634,449,530 - 34,498,911 (+)NCBIUU_Cfam_GSD_1.0
Gsr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494356,784,705 - 56,832,808 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936792531,756 - 579,166 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936792531,076 - 579,083 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1554,382,567 - 54,433,984 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11554,382,564 - 54,433,989 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21561,755,038 - 61,806,793 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GSR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1828,778,713 - 28,851,907 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605213,248,221 - 13,308,724 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gsr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478013,440,235 - 13,496,535 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478013,440,269 - 13,497,435 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Gsr
389 total Variants

Predicted Target Of
Summary Value
Count of predictions:438
Count of miRNA genes:232
Interacting mature miRNAs:269
Transcripts:ENSRNOT00000020252
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 20 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat

1 to 10 of 20 rows
RH141457  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,482,315 - 58,482,498 (+)MAPPERmRatBN7.2
Rnor_6.01662,197,428 - 62,197,610NCBIRnor6.0
Rnor_5.01661,859,412 - 61,859,594UniSTSRnor5.0
RGSC_v3.41662,254,812 - 62,254,994UniSTSRGSC3.4
Celera1656,518,367 - 56,518,549UniSTS
RH 3.4 Map16560.71UniSTS
Cytogenetic Map16q12.3UniSTS
RH144224  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,518,859 - 58,519,012 (+)MAPPERmRatBN7.2
Rnor_6.01662,233,971 - 62,234,123NCBIRnor6.0
Rnor_5.01661,895,955 - 61,896,107UniSTSRnor5.0
RGSC_v3.41662,291,124 - 62,291,276UniSTSRGSC3.4
Celera1656,554,903 - 56,555,055UniSTS
RH 3.4 Map16541.6UniSTS
Cytogenetic Map16q12.3UniSTS
AI230105  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21658,482,498 - 58,482,689 (+)MAPPERmRatBN7.2
Rnor_6.01662,197,611 - 62,197,801NCBIRnor6.0
Rnor_5.01661,859,595 - 61,859,785UniSTSRnor5.0
RGSC_v3.41662,254,995 - 62,255,185UniSTSRGSC3.4
Celera1656,518,550 - 56,518,740UniSTS
RH 3.4 Map16542.51UniSTS
Cytogenetic Map16q12.3UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000020252   ⟹   ENSRNOP00000020252
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,482,505 - 58,517,057 (-)Ensembl
Rnor_6.0 Ensembl1662,197,617 - 62,239,987 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090036   ⟹   ENSRNOP00000068989
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,482,505 - 58,511,298 (-)Ensembl
Rnor_6.0 Ensembl1662,198,178 - 62,241,361 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094128   ⟹   ENSRNOP00000084963
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1658,482,505 - 58,525,661 (-)Ensembl
RefSeq Acc Id: NM_053906   ⟹   NP_446358
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,185,574 - 65,227,975 (-)NCBI
mRatBN7.21658,482,505 - 58,524,909 (-)NCBI
Rnor_6.01662,197,617 - 62,239,987 (-)NCBI
Rnor_5.01661,859,601 - 61,901,971 (-)NCBI
RGSC_v3.41662,255,562 - 62,298,458 (-)RGD
Celera1656,518,556 - 56,560,956 (-)NCBI
Sequence:
RefSeq Acc Id: XR_005494529
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81665,186,269 - 65,228,742 (-)NCBI
mRatBN7.21658,482,209 - 58,525,256 (-)NCBI
Protein RefSeqs NP_446358 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB18132 (Get FASTA)   NCBI Sequence Viewer  
  EDM09143 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000084963
GenBank Protein P70619 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446358   ⟸   NM_053906
- UniProtKB: A6IVS9 (UniProtKB/TrEMBL),   A0A0G2JU71 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068989   ⟸   ENSRNOT00000090036
Ensembl Acc Id: ENSRNOP00000020252   ⟸   ENSRNOT00000020252
Ensembl Acc Id: ENSRNOP00000084963   ⟸   ENSRNOT00000094128
FAD/NAD(P)-binding   Pyridine nucleotide-disulphide oxidoreductase

Name Modeler Protein Id AA Range Protein Structure
AF-P70619-F1-model_v2 AlphaFold P70619 1-424 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11120 BioCyc
BioCyc Pathway PWY-4081 [glutathione-peroxide redox reactions] BioCyc
BioCyc Pathway Image PWY-4081 BioCyc
Ensembl Genes ENSRNOG00000014915 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000094128 ENTREZGENE
Gene3D-CATH 3.30.390.30 UniProtKB/Swiss-Prot
  3.50.50.60 UniProtKB/Swiss-Prot
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/Swiss-Prot
  Glutathione_Rdtase_euk/bac UniProtKB/Swiss-Prot
  GSHR/TRXR-like UniProtKB/Swiss-Prot
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/Swiss-Prot
NCBI Gene 116686 ENTREZGENE
PANTHER GLUTATHIONE REDUCTASE, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR42737 UniProtKB/Swiss-Prot
Pfam Pyr_redox_2 UniProtKB/Swiss-Prot
  Pyr_redox_dim UniProtKB/Swiss-Prot
PhenoGen Gsr PhenoGen
PRINTS FADPNR UniProtKB/Swiss-Prot
  PNDRDTASEI UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014915 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot
  SSF55424 UniProtKB/Swiss-Prot
UniProt A0A0G2JU71 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A0A3_RAT UniProtKB/TrEMBL
  A6IVS9 ENTREZGENE, UniProtKB/TrEMBL
  F1LRE1_RAT UniProtKB/TrEMBL
  GSHR_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-07 Gsr  glutathione-disulfide reductase  Gsr  glutathione reductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-06-27     Gsr  glutathione reductase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Gsr  glutathione reductase      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Gsr  glutathione reductase      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in Sertoli cells 632952