Keap1 (Kelch-like ECH-associated protein 1) - Rat Genome Database

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Gene: Keap1 (Kelch-like ECH-associated protein 1) Rattus norvegicus
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Symbol: Keap1
Name: Kelch-like ECH-associated protein 1
RGD ID: 621619
Description: Predicted to enable several functions, including disordered domain specific binding activity; transcription regulator inhibitor activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including response to immobilization stress; response to thyroid hormone; and selenium compound metabolic process. Located in adherens junction and focal adhesion. Part of protein-containing complex. Biomarker of diabetic retinopathy; end stage renal disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human KEAP1 (kelch like ECH associated protein 1); PARTICIPATES IN nuclear factor, erythroid 2 like 2 signaling pathway; ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,4-dinitrotoluene; 2-tert-butylhydroquinone; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cytosolic inhibitor of Nrf2; Inrf2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,044,555 - 28,054,042 (-)NCBIGRCr8
mRatBN7.2819,768,375 - 19,777,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,787,814 - 23,797,272 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,085,659 - 22,095,117 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,998,059 - 20,007,547 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,250,518 - 22,259,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,305,765 - 22,315,026 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,259,178 - 20,266,351 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,259,177 - 20,266,352 (-)NCBI
Celera821,161,976 - 21,171,435 (-)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Keap1RatAlcoholic Liver Diseases  ISOKEAP1 (Homo sapiens)6892954mRNA:decreased expression:liver (human)RGD 
Keap1Ratamyotrophic lateral sclerosis  ISOKEAP1 (Homo sapiens)6893397mRNA:increased expression:primary motor cortex (human)RGD 
Keap1RatChemical and Drug Induced Liver Injury  ISOKeap1 (Mus musculus)6893370 RGD 
Keap1RatChronic Hepatitis B  ISOKEAP1 (Homo sapiens)6892954mRNA:decreased expression:liver (human)RGD 
Keap1RatDiabetic Nephropathies  IDA 6893386 RGD 
Keap1Ratdiabetic retinopathy  IEP 10412733associated with Diabetes Mellitus more ...RGD 
Keap1Ratend stage renal disease  IEP 6892947protein:increased expression:renal cortex and cytosol (rat)RGD 
Keap1RatEndotoxemia  ISOKeap1 (Mus musculus)6892951 RGD 
Keap1Ratgallbladder cancer  ISOKEAP1 (Homo sapiens)6893398DNA:missense mutations and frameshift mutations:cds:multiple (human)RGD 
Keap1Ratidiopathic interstitial pneumonia  ISOKEAP1 (Homo sapiens)6893300protein:increased expression:hyperplastic lung epithelium and alveolus (human)RGD 
Keap1Ratpulmonary emphysema  ISOKEAP1 (Homo sapiens)5134973protein:increased expression:lung (human)RGD 
Keap1Ratpulmonary emphysema onsetISOKeap1 (Mus musculus)6893395 RGD 
Keap1RatReperfusion Injury  IEP 6902919protein:decreased expression:left coronary artery (rat)RGD 
Keap1RatReperfusion Injury  ISOKeap1 (Mus musculus)6893270protein:decreased expression:brain more ...RGD 
Keap1RatSepsis  ISOKeap1 (Mus musculus)6892955 RGD 
Keap1Ratsteatotic liver disease  ISOKeap1 (Mus musculus)6893372 RGD 
Keap1Rattransient cerebral ischemia  ISOKeap1 (Mus musculus)6893270protein:decreased expression:brain (mouse)RGD 
Keap1Ratureteral obstruction  IEP 5133246protein:altered expression:kidney cortex (rat)RGD 
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Keap1Ratfamilial hypercholesterolemia  ISOKEAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial hypercholesterolemiaClinVarPMID:20809525 more ...
Keap1Ratimmunodeficiency 35  ISOKEAP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 35ClinVarPMID:22402565 more ...
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Keap1RatDisease Progression  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20124447
Keap1Ratextrahepatic cholestasis  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
Keap1RatGallbladder Neoplasms  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18692501
Keap1Ratgastrointestinal system disease  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20404090
Keap1RatHepatic Insufficiency  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
Keap1Rathepatitis  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20404090
Keap1RatHepatomegaly  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
Keap1Ratkeratosis  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20404090
Keap1Ratlung non-small cell carcinoma  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22684020
Keap1Ratprimary biliary cholangitis  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30026087
Keap1RatProstatic Neoplasms  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24763052 and PMID:29610475
Keap1Ratrenal cell carcinoma  ISOKEAP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23797736
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Keap1Rat(+)-albicanol multiple interactionsISOKeap1 (Mus musculus)6480464albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 mRNA] and albicanol inhibits the reaction [Galactose results in increased expression of KEAP1 protein]CTDPMID:33761044
Keap1Rat(-)-ephedrine multiple interactionsISOKEAP1 (Homo sapiens)6480464Ephedrine inhibits the reaction [Bleomycin results in increased expression of KEAP1 protein]CTDPMID:37778983
Keap1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOKEAP1 (Homo sapiens)6480464epigallocatechin gallate promotes the reaction [arsenite results in increased expression of KEAP1 mRNA]CTDPMID:29572906
Keap1Rat(-)-epigallocatechin 3-gallate increases expressionISOKEAP1 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of KEAP1 proteinCTDPMID:35218280
Keap1Rat(R)-lipoic acid increases expressionISOKEAP1 (Homo sapiens)6480464Thioctic Acid results in increased expression of KEAP1 proteinCTDPMID:19033392
Keap1Rat(R)-lipoic acid multiple interactionsISOKeap1 (Mus musculus)6480464Thioctic Acid inhibits the reaction [Silicon results in increased expression of KEAP1 protein]CTDPMID:34252510
Keap1Rat(R,R,R)-alpha-tocopherol multiple interactionsISOKEAP1 (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 mRNA] and alpha-Tocopherol inhibits the reaction [Hydrogen Peroxide results in increased expression of KEAP1 protein]CTDPMID:36058301
Keap1Rat(S)-ropivacaine multiple interactionsISOKEAP1 (Homo sapiens)6480464[Ropivacaine results in increased susceptibility to Cisplatin] which results in increased expression of KEAP1 protein and SIRT1 protein affects the reaction [[Ropivacaine results in increased susceptibility to Cisplatin] which results in increased expression of KEAP1 protein]CTDPMID:39053794
Keap1Rat1,2-dimethylhydrazine multiple interactionsISOKeap1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of KEAP1 mRNACTDPMID:22206623
Keap1Rat1,2-naphthoquinone affects response to substanceISOKeap1 (Mus musculus)6480464KEAP1 protein affects the susceptibility to 1 and 2-naphthoquinoneCTDPMID:21384861
Keap1Rat1,2-naphthoquinone increases metabolic processingISOKeap1 (Mus musculus)64804641 and 2-naphthoquinone results in increased metabolism of KEAP1 proteinCTDPMID:21384861 and PMID:25807370
Keap1Rat1-chloro-2,4-dinitrobenzene multiple interactionsISOKEAP1 (Homo sapiens)6480464Acetylcysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of KEAP1 protein] more ...CTDPMID:19033392 and PMID:25742418
Keap1Rat1-chloro-2,4-dinitrobenzene decreases expressionISOKeap1 (Mus musculus)6480464Dinitrochlorobenzene results in decreased expression of KEAP1 mRNACTDPMID:28219650
Keap1Rat1-chloro-2,4-dinitrobenzene increases expressionISOKEAP1 (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of KEAP1 proteinCTDPMID:19033392
Keap1Rat1-chloro-2,4-dinitrobenzene affects metabolic processingISOKeap1 (Mus musculus)6480464Dinitrochlorobenzene affects the metabolism of KEAP1 proteinCTDPMID:18785192
Keap1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOKeap1 (Mus musculus)64804641 more ...CTDPMID:33368846 and PMID:38016618
Keap1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISOKeap1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:38016618
Keap1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOKeap1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:33368846
Keap1Rat1-naphthyl isothiocyanate decreases expressionISOKeap1 (Mus musculus)64804641-Naphthylisothiocyanate results in decreased expression of KEAP1 mRNA and 1-Naphthylisothiocyanate results in decreased expression of KEAP1 proteinCTDPMID:36008890 and PMID:37348807
Keap1Rat1-naphthyl isothiocyanate multiple interactionsISOKeap1 (Mus musculus)6480464liquiritin promotes the reaction [1-Naphthylisothiocyanate results in decreased expression of KEAP1 protein]CTDPMID:36008890

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Biological Process
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Original Reference(s)
Keap1Ratcellular response to carbohydrate stimulus  IDA 6902900falcarindiolRGD 
Keap1Ratcellular response to interleukin-4 acts_upstream_of_or_withinISOKeap1 (Mus musculus)1624291 PMID:9798653RGDPMID:9798653
Keap1Ratcellular response to interleukin-4 acts_upstream_of_or_withinIEAUniProtKB:Q9Z2X8 and ensembl:ENSMUSP000001310291600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratcellular response to oxidative stress involved_inISOKeap1 (Mus musculus)1624291 PMID:15282312 and PMID:15367669RGDPMID:15282312 and PMID:15367669
Keap1Ratcellular response to oxidative stress involved_inISOKEAP1 (Homo sapiens)1624291 PMID:15601839RGDPMID:15601839
Keap1Ratcellular response to oxidative stress involved_inIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratcellular response to oxidative stress involved_inIEAUniProtKB:Q9Z2X8 and ensembl:ENSMUSP000001310291600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratcellular response to oxidative stress involved_inISSUniProtKB:Q9Z2X81600115GO_REF:0000024UniProtGO_REF:0000024
Keap1Ratin utero embryonic development acts_upstream_of_or_withinIEAUniProtKB:Q9Z2X8 and ensembl:ENSMUSP000001310291600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratin utero embryonic development acts_upstream_of_or_withinISOKeap1 (Mus musculus)1624291MGI:2681416 PMID:15087497RGDPMID:15087497
Keap1Ratnegative regulation of gene expression  IDA 6902900 RGD 
Keap1Ratnegative regulation of response to oxidative stress involved_inIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratnegative regulation of response to oxidative stress involved_inISOKEAP1 (Homo sapiens)1624291 PMID:15601839RGDPMID:15601839
Keap1Ratnegative regulation of transcription by RNA polymerase II involved_inIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratnegative regulation of transcription by RNA polymerase II involved_inISOKEAP1 (Homo sapiens)1624291 PMID:17015834RGDPMID:17015834
Keap1Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inISOKEAP1 (Homo sapiens)1624291 PMID:15601839RGDPMID:15601839
Keap1Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIBAFB:FBgn0037978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Keap1Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratprotein ubiquitination involved_inISOKEAP1 (Homo sapiens)1624291 PMID:15601839 and PMID:15983046RGDPMID:15601839 and PMID:15983046
Keap1Ratprotein ubiquitination involved_inIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Keap1Ratactin filament located_inISOKeap1 (Mus musculus)1624291 PMID:14764898RGDPMID:14764898
Keap1Ratactin filament part_ofIEAUniProtKB:Q9Z2X8 and ensembl:ENSMUSP000001310291600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratadherens junction  IDA 2302250 RGD 
Keap1Ratcentriolar satellite located_inIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratcentriolar satellite located_inISOKEAP1 (Homo sapiens)1624291 RGDGO_REF:0000052
Keap1RatCul3-RING ubiquitin ligase complex part_ofISSUniProtKB:Q141451600115GO_REF:0000024UniProtGO_REF:0000024
Keap1RatCul3-RING ubiquitin ligase complex part_ofISOKeap1 (Mus musculus)1624291 PMID:15282312 and PMID:15367669RGDPMID:15282312 and PMID:15367669
Keap1RatCul3-RING ubiquitin ligase complex part_ofIBAFB:FBgn0037978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Keap1RatCul3-RING ubiquitin ligase complex part_ofISOKEAP1 (Homo sapiens)1624291 PMID:15601839 and PMID:15983046RGDPMID:15601839 and PMID:15983046
Keap1RatCul3-RING ubiquitin ligase complex part_ofIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1RatCul3-RING ubiquitin ligase complex part_ofIEAUniProtKB:Q9Z2X8 and ensembl:ENSMUSP000001310291600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratcytoplasm located_inIEAUniProtKB:Q9Z2X8 and ensembl:ENSMUSP000001310291600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Keap1Ratcytoplasm located_inISOKeap1 (Mus musculus)1624291PR:Q60795 PMID:14517290 and PMID:15367669RGDPMID:14517290 and PMID:15367669
Keap1Ratcytoplasm located_inIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratcytoplasm is_active_inIBAMGI:1858732 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Keap1Ratcytoplasm located_inISOKEAP1 (Homo sapiens)1624291 PMID:15601839 and PMID:19424503RGDPMID:15601839 and PMID:19424503
Keap1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Keap1Ratcytosol located_inISOKEAP1 (Homo sapiens)1624291 RGDGO_REF:0000052
Keap1Ratcytosol located_inIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Keap1Ratdisordered domain specific binding enablesIEAUniProtKB:Q9Z2X8 and ensembl:ENSMUSP000001310291600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratdisordered domain specific binding enablesISOKeap1 (Mus musculus)1624291UniProtKB:Q61985 and PMID:16581765RGDPMID:16581765
Keap1Ratidentical protein binding enablesIEAUniProtKB:Q9Z2X8 and ensembl:ENSMUSP000001310291600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratidentical protein binding enablesISOKeap1 (Mus musculus)1624291UniProtKB:Q9Z2X8 more ...RGDPMID:16581765 and PMID:20133743
Keap1Ratprotein binding enablesISOKEAP1 (Homo sapiens)1624291UniProtKB:A9UGY9 more ...RGDPMID:15601839 more ...
Keap1Ratprotein binding  IPINfe2l2 (Mus musculus)727319 RGD 
Keap1Ratprotein binding enablesISOKeap1 (Mus musculus)1624291PR:Q60795 more ...RGDPMID:12151510 more ...
Keap1RatRNA polymerase II-specific DNA-binding transcription factor binding enablesIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1RatRNA polymerase II-specific DNA-binding transcription factor binding enablesISOKEAP1 (Homo sapiens)1624291UniProtKB:Q16236 and PMID:17015834RGDPMID:17015834
Keap1Rattranscription regulator inhibitor activity enablesIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Rattranscription regulator inhibitor activity enablesISOKEAP1 (Homo sapiens)1624291 PMID:17015834RGDPMID:17015834
Keap1Ratubiquitin-like ligase-substrate adaptor activity enablesIEAUniProtKB:Q14145 and ensembl:ENSP000001711111600115GO_REF:0000107EnsemblGO_REF:0000107
Keap1Ratubiquitin-like ligase-substrate adaptor activity enablesIBAFB:FBgn0037978 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Keap1Ratubiquitin-like ligase-substrate adaptor activity enablesISOKEAP1 (Homo sapiens)1624291 PMID:15572695 and PMID:15601839RGDPMID:15572695 and PMID:15601839
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
Keap1Ratubiquitin/proteasome degradation pathway  IEA 6907045 KEGGrno:04120

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Reference Title
Reference Citation
1. Deletion of Keap1 in the lung attenuates acute cigarette smoke-induced oxidative stress and inflammation. Blake DJ, etal., Am J Respir Cell Mol Biol. 2010 May;42(5):524-36. Epub 2009 Jun 11.
2. Functional characterization and role of INrf2 in antioxidant response element-mediated expression and antioxidant induction of NAD(P)H:quinone oxidoreductase1 gene. Dhakshinamoorthy S and Jaiswal AK, Oncogene 2001 Jun 28;20(29):3906-17.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Altered Nrf2/Keap1-Bach1 equilibrium in pulmonary emphysema. Goven D, etal., Thorax. 2008 Oct;63(10):916-24. Epub 2008 Jun 17.
5. Oxidative injury induces selective rather than global inhibition of proteasomal activity. Gurusamy N, etal., J Mol Cell Cardiol. 2008 Feb;44(2):419-28. Epub 2007 Oct 22.
6. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
7. The complexity of the Nrf2 pathway: beyond the antioxidant response. Huang Y, etal., J Nutr Biochem. 2015 Dec;26(12):1401-13. doi: 10.1016/j.jnutbio.2015.08.001. Epub 2015 Aug 8.
8. Transcription factor Nrf2/MafK regulates rat placental glutathione S-transferase gene during hepatocarcinogenesis. Ikeda H, etal., Biochem J. 2004 Jun 1;380(Pt 2):515-21.
9. Contribution of impaired Nrf2-Keap1 pathway to oxidative stress and inflammation in chronic renal failure. Kim HJ and Vaziri ND, Am J Physiol Renal Physiol. 2010 Mar;298(3):F662-71. Epub 2009 Dec 9.
10. Functional dissection of Nrf2-dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA. Kim JH, etal., Free Radic Biol Med. 2012 Aug 1;53(3):629-40. Epub 2012 Apr 27.
11. Differentially expressed genes and morphological changes during lengthened immobilization in rat soleus muscle. Kim JW, etal., Differentiation. 2007 Feb;75(2):147-57.
12. Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis. Kong X, etal., Am J Respir Crit Care Med. 2011 Oct 15;184(8):928-38. Epub 2011 Jul 28.
13. Nuclear factor erythroid 2-like 2 (Nrf2) expression in end-stage liver disease. Kurzawski M, etal., Environ Toxicol Pharmacol. 2012 Jul;34(1):87-95. Epub 2012 Mar 11.
14. Cell-specific elevation of NRF2 and sulfiredoxin-1 as markers of oxidative stress in the lungs of idiopathic pulmonary fibrosis and non-specific interstitial pneumonia. Mazur W, etal., APMIS. 2010 Sep 1;118(9):703-12.
15. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Nrf2 controls constitutive and inducible expression of ARE-driven genes through a dynamic pathway involving nucleocytoplasmic shuttling by Keap1. Nguyen T, etal., J Biol Chem. 2005 Sep 16;280(37):32485-92. Epub 2005 Jul 6.
18. Activation of the Nrf2/ARE pathway via S-alkylation of cysteine 151 in the chemopreventive agent-sensor Keap1 protein by falcarindiol, a conjugated diacetylene compound. Ohnuma T, etal., Toxicol Appl Pharmacol. 2010 Apr 1;244(1):27-36. Epub 2009 Dec 21.
19. Nrf2 inhibits hepatic iron accumulation and counteracts oxidative stress-induced liver injury in nutritional steatohepatitis. Okada K, etal., J Gastroenterol. 2012 Aug;47(8):924-35. Epub 2012 Feb 28.
20. Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in mice. Osburn WO, etal., Toxicol Sci. 2008 Jul;104(1):218-27. Epub 2008 Apr 15.
1 to 20 of 35 rows
PMID:9798653   PMID:11921171   PMID:12682069   PMID:14517290   PMID:14764898   PMID:15087497   PMID:15166316   PMID:15282312   PMID:15367669   PMID:15601839   PMID:15983046   PMID:16581765  
PMID:17015834   PMID:17468336   PMID:17982879   PMID:19424503   PMID:20133743   PMID:20173742   PMID:20421418   PMID:20452972   PMID:21703357   PMID:24211725   PMID:24796746   PMID:24796753  
PMID:25049078   PMID:25301875   PMID:25598205   PMID:26655811   PMID:27223823   PMID:27472294   PMID:27815660   PMID:28145852   PMID:29119264   PMID:29845199   PMID:30071128   PMID:30119254  
PMID:31273531   PMID:31355603   PMID:31432116   PMID:31563143   PMID:32590729   PMID:32894623   PMID:33760324   PMID:33777321   PMID:33811899   PMID:34185425   PMID:34278476   PMID:35026282  
PMID:36736873   PMID:37822721   PMID:38308640  



Keap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8828,044,555 - 28,054,042 (-)NCBIGRCr8
mRatBN7.2819,768,375 - 19,777,862 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,787,814 - 23,797,272 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0822,085,659 - 22,095,117 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,998,059 - 20,007,547 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,250,518 - 22,259,868 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,305,765 - 22,315,026 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,259,178 - 20,266,351 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,259,177 - 20,266,352 (-)NCBI
Celera821,161,976 - 21,171,435 (-)NCBICelera
Cytogenetic Map8q13NCBI
KEAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,486,125 - 10,503,356 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,486,125 - 10,503,558 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,596,801 - 10,614,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,457,796 - 10,475,054 (-)NCBINCBI36Build 36hg18NCBI36
Celera1910,491,509 - 10,508,764 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,176,101 - 10,192,927 (-)NCBIHuRef
CHM1_11910,597,575 - 10,614,823 (-)NCBICHM1_1
T2T-CHM13v2.01910,612,569 - 10,629,791 (-)NCBIT2T-CHM13v2.0
Keap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,141,026 - 21,150,628 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,141,026 - 21,150,657 (-)EnsemblGRCm39 Ensembl
GRCm38921,229,730 - 21,239,332 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,229,730 - 21,239,361 (-)EnsemblGRCm38mm10GRCm38
MGSCv37921,034,174 - 21,043,776 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,980,469 - 20,989,215 (-)NCBIMGSCv36mm8
Celera918,498,845 - 18,508,447 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.74NCBI
Keap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,704,695 - 1,711,290 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,704,695 - 1,711,339 (-)NCBIChiLan1.0ChiLan1.0
KEAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,404,143 - 15,421,611 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,402,746 - 14,420,092 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01910,037,544 - 10,055,091 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,701,298 - 10,717,664 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,701,303 - 10,717,604 (-)Ensemblpanpan1.1panPan2
KEAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,651,070 - 50,661,178 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,650,711 - 50,658,496 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,523,052 - 50,533,206 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,174,558 - 51,182,077 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,164,570 - 51,185,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,380,711 - 50,390,863 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,808,833 - 50,818,993 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,049,891 - 51,060,051 (+)NCBIUU_Cfam_GSD_1.0
Keap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,560,465 - 209,569,647 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659782,340 - 793,688 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659785,059 - 793,775 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KEAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,276,336 - 69,294,382 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,280,940 - 69,290,267 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,634,153 - 69,643,610 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KEAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,515,789 - 9,526,699 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,515,416 - 9,522,797 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,471,467 - 10,484,386 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Keap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,580,861 - 2,595,275 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,580,812 - 2,595,023 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Keap1
16 total Variants

Predicted Target Of
Summary Value
Count of predictions:78
Count of miRNA genes:64
Interacting mature miRNAs:77
Transcripts:ENSRNOT00000028360
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat

1 to 10 of 23 rows
RH132242  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,768,815 - 19,769,017 (+)MAPPERmRatBN7.2
Rnor_6.0822,250,959 - 22,251,160NCBIRnor6.0
Rnor_5.0822,306,206 - 22,306,407UniSTSRnor5.0
RGSC_v3.4820,258,900 - 20,259,101UniSTSRGSC3.4
Celera821,162,417 - 21,162,618UniSTS
RH 3.4 Map8178.1UniSTS
Cytogenetic Map8q13UniSTS
RH142508  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,776,593 - 19,776,733 (+)MAPPERmRatBN7.2
Rnor_6.0822,258,734 - 22,258,873NCBIRnor6.0
Rnor_5.0822,313,981 - 22,314,120UniSTSRnor5.0
RGSC_v3.4820,266,678 - 20,266,817UniSTSRGSC3.4
Celera821,170,167 - 21,170,306UniSTS
RH 3.4 Map8205.19UniSTS
Cytogenetic Map8q13UniSTS
RH137423  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,769,609 - 19,769,792 (+)MAPPERmRatBN7.2
Rnor_6.0822,251,753 - 22,251,935NCBIRnor6.0
Rnor_5.0822,307,000 - 22,307,182UniSTSRnor5.0
RGSC_v3.4820,259,694 - 20,259,876UniSTSRGSC3.4
Celera821,163,211 - 21,163,393UniSTS
Cytogenetic Map8q13UniSTS
RH138725  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,772,493 - 19,772,668 (+)MAPPERmRatBN7.2
Rnor_6.0822,254,636 - 22,254,810NCBIRnor6.0
Rnor_5.0822,309,883 - 22,310,057UniSTSRnor5.0
RGSC_v3.4820,262,578 - 20,262,752UniSTSRGSC3.4
Celera821,166,069 - 21,166,243UniSTS
Cytogenetic Map8q13UniSTS
RH138813  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,768,411 - 19,768,587 (+)MAPPERmRatBN7.2
Rnor_6.0822,250,555 - 22,250,730NCBIRnor6.0
Rnor_5.0822,305,802 - 22,305,977UniSTSRnor5.0
RGSC_v3.4820,258,496 - 20,258,671UniSTSRGSC3.4
Celera821,162,013 - 21,162,188UniSTS
Cytogenetic Map8q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000028360   ⟹   ENSRNOP00000028360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,768,375 - 19,777,862 (-)Ensembl
Rnor_6.0 Ensembl822,250,518 - 22,259,779 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101216   ⟹   ENSRNOP00000081740
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,768,692 - 19,777,333 (-)Ensembl
RefSeq Acc Id: NM_057152   ⟹   NP_476493
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,044,555 - 28,054,042 (-)NCBI
mRatBN7.2819,768,375 - 19,777,862 (-)NCBI
Rnor_6.0822,250,518 - 22,259,779 (-)NCBI
Rnor_5.0822,305,765 - 22,315,026 (-)NCBI
RGSC_v3.4820,259,178 - 20,266,351 (-)RGD
Celera821,161,976 - 21,171,435 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006242591   ⟹   XP_006242653
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,044,874 - 28,053,907 (-)NCBI
mRatBN7.2819,768,694 - 19,777,726 (-)NCBI
Rnor_6.0822,250,521 - 22,259,868 (-)NCBI
Rnor_5.0822,305,765 - 22,315,026 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080715   ⟹   XP_038936643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8828,044,874 - 28,053,625 (-)NCBI
mRatBN7.2819,768,694 - 19,777,444 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_476493 (Get FASTA)   NCBI Sequence Viewer  
  XP_006242653 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936643 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG16275 (Get FASTA)   NCBI Sequence Viewer  
  EDL78313 (Get FASTA)   NCBI Sequence Viewer  
  EDL78314 (Get FASTA)   NCBI Sequence Viewer  
  EDL78315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028360
GenBank Protein P57790 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_476493   ⟸   NM_057152
- UniProtKB: G3V8U2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006242653   ⟸   XM_006242591
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVM9 (UniProtKB/TrEMBL),   A6JNQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028360   ⟸   ENSRNOT00000028360
RefSeq Acc Id: XP_038936643   ⟸   XM_039080715
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZVM9 (UniProtKB/TrEMBL),   A6JNQ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000081740   ⟸   ENSRNOT00000101216
BACK   BTB

Name Modeler Protein Id AA Range Protein Structure
AF-P57790-F1-model_v2 AlphaFold P57790 1-624 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-31432 BioCyc
Ensembl Genes ENSRNOG00000020878 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000028360 ENTREZGENE
Gene3D-CATH 1.25.40.420 UniProtKB/Swiss-Prot
  2.120.10.80 UniProtKB/Swiss-Prot
  Potassium Channel Kv1.1, Chain A UniProtKB/Swiss-Prot
InterPro BACK UniProtKB/Swiss-Prot
  BTB-kelch_protein UniProtKB/Swiss-Prot
  BTB/POZ_dom UniProtKB/Swiss-Prot
  KEAP1 UniProtKB/Swiss-Prot
  KEAP1_BACK UniProtKB/Swiss-Prot
  Kelch-typ_b-propeller UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
  SKP1/BTB/POZ_sf UniProtKB/Swiss-Prot
NCBI Gene 117519 ENTREZGENE
PANTHER KELCH-LIKE PROTEIN 26 UniProtKB/Swiss-Prot
  LD33804P UniProtKB/Swiss-Prot
Pfam BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch_1 UniProtKB/Swiss-Prot
PhenoGen Keap1 PhenoGen
PIRSF Kelch-like_protein_gigaxonin UniProtKB/Swiss-Prot
PROSITE BTB UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020878 RatGTEx
SMART BACK UniProtKB/Swiss-Prot
  BTB UniProtKB/Swiss-Prot
  Kelch UniProtKB/Swiss-Prot
Superfamily-SCOP SSF117281 UniProtKB/Swiss-Prot
  SSF54695 UniProtKB/Swiss-Prot
UniProt A0A8I5ZVM9 ENTREZGENE, UniProtKB/TrEMBL
  A6JNQ1 ENTREZGENE, UniProtKB/TrEMBL
  G3V8U2 ENTREZGENE, UniProtKB/TrEMBL
  KEAP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q9ERI3 UniProtKB/Swiss-Prot
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Keap1  Kelch-like ECH-associated protein 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Keap1  Kelch-like ECH-associated protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_drugs releases Nrf2 following administration of antioxidants and xenobiotics 727319
gene_process involved in repression of Antioxidant response element (ARE)-mediated NQO1 gene expression 727319