Atxn3 (ataxin 3) - Rat Genome Database

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Gene: Atxn3 (ataxin 3) Rattus norvegicus
Analyze
Symbol: Atxn3
Name: ataxin 3
RGD ID: 621567
Description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone deacetylase binding activity; and transcription corepressor binding activity. Contributes to histone deacetylase activity. Involved in protein modification process. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nucleus. Predicted to be active in lysosomal membrane and nucleus. Predicted to colocalize with endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in Machado-Joseph disease and late onset Parkinson's disease. Orthologous to human ATXN3 (ataxin 3); PARTICIPATES IN mitochondrial autophagy pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17beta-estradiol; 4,4'-diaminodiphenylmethane; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ataxin-3; machado-Joseph disease protein 1 homolog; MJD1; Rsca3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86126,837,107 - 126,872,919 (-)NCBIGRCr8
mRatBN7.26121,072,228 - 121,107,902 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,223,964 - 121,257,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,519,222 - 121,552,743 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06120,855,537 - 120,889,057 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06125,817,420 - 125,853,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6125,819,640 - 125,853,461 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,029,278 - 135,065,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,196,043 - 126,229,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,199,789 - 126,233,591 (-)NCBI
Celera6118,571,601 - 118,605,060 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-hydroxypropanoic acid  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
acetamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
chlorpyrifos  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
dinophysistoxin 1  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethyl methanesulfonate  (ISO)
flavonoids  (EXP)
formaldehyde  (ISO)
hypochlorous acid  (ISO)
L-serine  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
okadaic acid  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
poly(I:C)  (EXP)
potassium chromate  (ISO)
quercetin  (ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
rutin  (EXP)
Salinomycin  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
succimer  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Alves S, etal., Hum Mol Genet. 2008 Jul 15;17(14):2071-83. Epub 2008 Apr 1.
2. Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3? Alves S, etal., Hum Mol Genet. 2010 Jun 15;19(12):2380-94. doi: 10.1093/hmg/ddq111. Epub 2010 Mar 22.
3. Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease. Alves S, etal., PLoS One. 2008 Oct 8;3(10):e3341. doi: 10.1371/journal.pone.0003341.
4. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. Beuckmann CT, etal., J Neurosci 2004 May 5;24(18):4469-77.
5. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
6. Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. Evert BO, etal., J Neurosci. 2006 Nov 1;26(44):11474-86.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Kawaguchi Y, etal., Nat Genet. 1994 Nov;8(3):221-8.
9. Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3. Masino L, etal., J Mol Biol 2004 Dec 3;344(4):1021-35.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Information Derived from GenBank Report RGD, Sept. 2003
18. An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients. Schmidt T, etal., Brain Pathol. 1998 Oct;8(4):669-79.
Additional References at PubMed
PMID:10732811   PMID:12486728   PMID:16525503   PMID:17000876   PMID:17626202   PMID:17764659   PMID:18353661   PMID:19542537   PMID:19666135   PMID:19843543   PMID:20347968   PMID:20637808  
PMID:20940148   PMID:21855799   PMID:22129356   PMID:22970133   PMID:24063750   PMID:24068323   PMID:24548080   PMID:25143392   PMID:26880203  


Genomics

Comparative Map Data
Atxn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86126,837,107 - 126,872,919 (-)NCBIGRCr8
mRatBN7.26121,072,228 - 121,107,902 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,223,964 - 121,257,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,519,222 - 121,552,743 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06120,855,537 - 120,889,057 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06125,817,420 - 125,853,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6125,819,640 - 125,853,461 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,029,278 - 135,065,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,196,043 - 126,229,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,199,789 - 126,233,591 (-)NCBI
Celera6118,571,601 - 118,605,060 (-)NCBICelera
Cytogenetic Map6q32NCBI
ATXN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,044,775 - 92,106,582 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,044,496 - 92,106,621 (-)EnsemblGRCh38hg38GRCh38
GRCh371492,524,896 - 92,572,926 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361491,598,883 - 91,642,707 (-)NCBINCBI36Build 36hg18NCBI36
Celera1472,577,489 - 72,625,559 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1472,705,822 - 72,754,183 (-)NCBIHuRef
CHM1_11492,463,194 - 92,511,266 (-)NCBICHM1_1
T2T-CHM13v2.01486,274,279 - 86,336,122 (-)NCBIT2T-CHM13v2.0
Atxn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912101,885,160 - 101,928,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12101,885,160 - 101,924,505 (-)EnsemblGRCm39 Ensembl
GRCm3812101,918,901 - 101,959,121 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12101,918,901 - 101,958,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712103,157,111 - 103,196,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,320,604 - 102,359,232 (-)NCBIMGSCv36mm8
Celera12103,135,861 - 103,175,388 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.32NCBI
Atxn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,405,643 - 14,440,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,405,415 - 14,443,457 (-)NCBIChiLan1.0ChiLan1.0
ATXN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,222,124 - 93,265,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11492,433,581 - 92,481,947 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01472,693,446 - 72,741,772 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,041,114 - 92,083,840 (-)NCBIpanpan1.1PanPan1.1panPan2
ATXN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,318,440 - 1,354,814 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,247,155 - 1,354,720 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,337,255 - 1,373,511 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,367,340 - 1,403,659 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,367,738 - 1,403,671 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,305,295 - 1,341,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,261,283 - 1,297,915 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,382,578 - 1,418,851 (-)NCBIUU_Cfam_GSD_1.0
Atxn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864013,119,860 - 13,160,641 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733310,836 - 347,112 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733306,400 - 347,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATXN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7113,608,783 - 113,645,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17113,611,566 - 113,645,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,219,165 - 120,253,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATXN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12469,810,433 - 69,855,308 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605357,057,799 - 57,105,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atxn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247348,685,994 - 8,726,329 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Atxn3
69 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1288
Count of miRNA genes:348
Interacting mature miRNAs:489
Transcripts:ENSRNOT00000007505
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)693701310128713626Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 28 12 19 12 1 1 74 30 41 11 1
Low 1 41 29 29 29 7 10 5 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_021702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000007505   ⟹   ENSRNOP00000007505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)Ensembl
Rnor_6.0 Ensembl6125,819,640 - 125,853,461 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000098027   ⟹   ENSRNOP00000086715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,074,448 - 121,100,548 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099444   ⟹   ENSRNOP00000091691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)Ensembl
RefSeq Acc Id: NM_021702   ⟹   NP_067734
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,839,327 - 126,872,781 (-)NCBI
mRatBN7.26121,074,448 - 121,107,902 (-)NCBI
Rnor_6.06125,819,640 - 125,853,461 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
RGSC_v3.46126,196,043 - 126,229,844 (-)RGD
Celera6118,571,601 - 118,605,060 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240485   ⟹   XP_006240547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240486   ⟹   XP_006240548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240487   ⟹   XP_006240549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240488   ⟹   XP_006240550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,904 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240490   ⟹   XP_006240552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,676 (-)NCBI
mRatBN7.26121,072,228 - 121,107,791 (-)NCBI
Rnor_6.06125,817,420 - 125,853,326 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240493   ⟹   XP_006240555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,792 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594337   ⟹   XP_017449826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112811   ⟹   XP_038968739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,003 (-)NCBI
mRatBN7.26121,072,228 - 121,107,125 (-)NCBI
RefSeq Acc Id: XM_063262394   ⟹   XP_063118464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
RefSeq Acc Id: XM_063262395   ⟹   XP_063118465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,904 (-)NCBI
RefSeq Acc Id: XM_063262396   ⟹   XP_063118466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
RefSeq Acc Id: XM_063262397   ⟹   XP_063118467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,676 (-)NCBI
RefSeq Acc Id: XM_063262398   ⟹   XP_063118468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,502 (-)NCBI
RefSeq Acc Id: XM_063262399   ⟹   XP_063118469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,873 (-)NCBI
RefSeq Acc Id: XM_063262400   ⟹   XP_063118470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,919 (-)NCBI
RefSeq Acc Id: XM_063262401   ⟹   XP_063118471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,850,550 - 126,872,894 (-)NCBI
RefSeq Acc Id: XM_063262402   ⟹   XP_063118472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,851,849 - 126,872,771 (-)NCBI
RefSeq Acc Id: XM_063262403   ⟹   XP_063118473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,851,849 - 126,872,771 (-)NCBI
RefSeq Acc Id: XM_063262404   ⟹   XP_063118474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,850,550 - 126,872,789 (-)NCBI
Protein Sequences
Protein RefSeqs NP_067734 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240547 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240548 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240549 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240550 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240552 (Get FASTA)   NCBI Sequence Viewer  
  XP_006240555 (Get FASTA)   NCBI Sequence Viewer  
  XP_017449826 (Get FASTA)   NCBI Sequence Viewer  
  XP_038968739 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118464 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118465 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118466 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118467 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118468 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118469 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118470 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118471 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118472 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118473 (Get FASTA)   NCBI Sequence Viewer  
  XP_063118474 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA72986 (Get FASTA)   NCBI Sequence Viewer  
  EDL81739 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000007505
  ENSRNOP00000007505.1
  ENSRNOP00000086715.1
  ENSRNOP00000091691
  ENSRNOP00000091691.1
  ENSRNOP00055020411
  ENSRNOP00060005977
  ENSRNOP00065019676
GenBank Protein O35815 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_067734   ⟸   NM_021702
- UniProtKB: O35815 (UniProtKB/Swiss-Prot),   A6JEJ5 (UniProtKB/TrEMBL),   A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240550   ⟸   XM_006240488
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240548   ⟸   XM_006240486
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240555   ⟸   XM_006240493
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240549   ⟸   XM_006240487
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240547   ⟸   XM_006240485
- Peptide Label: isoform X1
- UniProtKB: A0A8I6GJ61 (UniProtKB/TrEMBL),   A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240552   ⟸   XM_006240490
- Peptide Label: isoform X11
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017449826   ⟸   XM_017594337
- Peptide Label: isoform X8
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000007505   ⟸   ENSRNOT00000007505
RefSeq Acc Id: XP_038968739   ⟸   XM_039112811
- Peptide Label: isoform X11
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086715   ⟸   ENSRNOT00000098027
RefSeq Acc Id: ENSRNOP00000091691   ⟸   ENSRNOT00000099444
RefSeq Acc Id: XP_063118470   ⟸   XM_063262400
- Peptide Label: isoform X12
RefSeq Acc Id: XP_063118465   ⟸   XM_063262395
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063118469   ⟸   XM_063262399
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063118466   ⟸   XM_063262396
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063118464   ⟸   XM_063262394
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063118467   ⟸   XM_063262397
- Peptide Label: isoform X10
RefSeq Acc Id: XP_063118468   ⟸   XM_063262398
- Peptide Label: isoform X11
RefSeq Acc Id: XP_063118471   ⟸   XM_063262401
- Peptide Label: isoform X13
RefSeq Acc Id: XP_063118474   ⟸   XM_063262404
- Peptide Label: isoform X16
RefSeq Acc Id: XP_063118473   ⟸   XM_063262403
- Peptide Label: isoform X15
RefSeq Acc Id: XP_063118472   ⟸   XM_063262402
- Peptide Label: isoform X14
Protein Domains
Josephin   UIM

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35815-F1-model_v2 AlphaFold O35815 1-355 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694779
Promoter ID:EPDNEW_R5304
Type:initiation region
Name:Atxn3_1
Description:ataxin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06125,853,368 - 125,853,428EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621567 AgrOrtholog
BioCyc Gene G2FUF-36463 BioCyc
Ensembl Genes ENSRNOG00000005470 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055014517 UniProtKB/Swiss-Prot
  ENSRNOG00060004720 UniProtKB/Swiss-Prot
  ENSRNOG00065015145 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007505 ENTREZGENE
  ENSRNOT00000007505.3 UniProtKB/Swiss-Prot
  ENSRNOT00000098027.1 UniProtKB/TrEMBL
  ENSRNOT00000099444.1 UniProtKB/TrEMBL
  ENSRNOT00055024976 UniProtKB/Swiss-Prot
  ENSRNOT00060007983 UniProtKB/Swiss-Prot
  ENSRNOT00065025136 UniProtKB/Swiss-Prot
Gene3D-CATH 3.90.70.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S15/NS1, RNA-binding UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ataxin-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Josephin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 60331 ENTREZGENE
PANTHER ATAXIN-3-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR14159 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Josephin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUIM_assoc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Atxn3 PhenoGen
PRINTS JOSEPHIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE JOSEPHIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005470 RatGTEx
  ENSRNOG00055014517 RatGTEx
  ENSRNOG00060004720 RatGTEx
  ENSRNOG00065015145 RatGTEx
SMART Josephin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UIM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A6D3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJ61 ENTREZGENE, UniProtKB/TrEMBL
  A6JEJ5 ENTREZGENE, UniProtKB/TrEMBL
  ATX3_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Atxn3  ataxin 3  Rsca3  rsca3 protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Rsca3  rsca3 protein      Symbol and Name status set to provisional 70820 PROVISIONAL