Atxn3 (ataxin 3) - Rat Genome Database

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Gene: Atxn3 (ataxin 3) Rattus norvegicus
Analyze
Symbol: Atxn3
Name: ataxin 3
RGD ID: 621567
Description: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; histone deacetylase binding activity; and transcription corepressor binding activity. Contributes to histone deacetylase activity. Involved in protein modification process. Predicted to be located in several cellular components, including endoplasmic reticulum membrane; mitochondrion; and nucleus. Predicted to be active in lysosomal membrane and nucleus. Human ortholog(s) of this gene implicated in Machado-Joseph disease and late onset Parkinson's disease. Orthologous to human ATXN3 (ataxin 3); PARTICIPATES IN mitochondrial autophagy pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17beta-estradiol; 4,4'-diaminodiphenylmethane; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ataxin-3; machado-Joseph disease protein 1 homolog; MJD1; Rsca3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86126,837,107 - 126,872,919 (-)NCBIGRCr8
mRatBN7.26121,072,228 - 121,107,902 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,223,964 - 121,257,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,519,222 - 121,552,743 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06120,855,537 - 120,889,057 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06125,817,420 - 125,853,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6125,819,640 - 125,853,461 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,029,278 - 135,065,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,196,043 - 126,229,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,199,789 - 126,233,591 (-)NCBI
Celera6118,571,601 - 118,605,060 (-)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
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Original Reference(s)
Atxn3Ratachondrogenesis type IA  ISOATXN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Achondrogenesis and type IAClinVarPMID:28492532
Atxn3Ratatrophic muscular disease  ISOATXN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Spinopontine atrophyClinVarPMID:25741868
Atxn3Ratgenetic disease  ISOATXN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Atxn3Ratlate onset Parkinson's disease  ISOATXN3 (Homo sapiens)8554872ClinVar Annotator: match by term: ATXN3-related conditionClinVarPMID:24033266 more ...
Atxn3RatMachado-Joseph disease  ISOATXN3 (Homo sapiens)8554872ClinVar Annotator: match by term: Azorean diseaseClinVarPMID:25741868
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Original Reference(s)
Atxn3RatMachado-Joseph disease  ISOATXN3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31378764
Atxn3RatNerve Degeneration  ISOATXN3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9635424
Object Symbol
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Original Reference(s)
Atxn3Ratlate onset Parkinson's disease  ISOATXN3 (Homo sapiens)7240710 OMIM 
Atxn3RatMachado-Joseph disease  ISOATXN3 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Atxn3Rat(-)-demecolcine increases expressionISOATXN3 (Homo sapiens)6480464Demecolcine results in increased expression of ATXN3 mRNACTDPMID:23649840
Atxn3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOATXN3 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ATXN3 mRNACTDPMID:22079256
Atxn3Rat17alpha-ethynylestradiol affects expressionISOAtxn3 (Mus musculus)6480464Ethinyl Estradiol affects the expression of ATXN3 mRNACTDPMID:17555576
Atxn3Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of ATXN3 mRNACTDPMID:17010207
Atxn3Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expressionISOATXN3 (Homo sapiens)6480464Metribolone results in increased expression of ATXN3 mRNACTDPMID:16751804
Atxn3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOAtxn3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ATXN3 mRNACTDPMID:21570461
Atxn3Rat2-hydroxypropanoic acid decreases expressionISOATXN3 (Homo sapiens)6480464Lactic Acid results in decreased expression of ATXN3 mRNACTDPMID:30851411
Atxn3Rat4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of ATXN3 mRNACTDPMID:30723492
Atxn3Rat4-hydroxyphenyl retinamide decreases expressionISOAtxn3 (Mus musculus)6480464Fenretinide results in decreased expression of ATXN3 mRNACTDPMID:28973697
Atxn3Rat5-aza-2'-deoxycytidine affects expressionISOATXN3 (Homo sapiens)6480464Decitabine affects the expression of ATXN3 mRNACTDPMID:23300844
Atxn3Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of ATXN3 mRNACTDPMID:31881176
Atxn3Ratacrolein multiple interactionsISOATXN3 (Homo sapiens)6480464[Acrolein co-treated with methacrylaldehyde co-treated with Ozone] results in decreased expression of ATXN3 mRNACTDPMID:32845096
Atxn3Rataflatoxin B1 increases expressionISOATXN3 (Homo sapiens)6480464Aflatoxin B1 results in increased expression of ATXN3 mRNACTDPMID:21641981 and PMID:22100608
Atxn3Rataluminium atom affects foldingISOAtxn3 (Mus musculus)6480464Aluminum affects the folding of ATXN3 protein polymorphismCTDPMID:17300980
Atxn3Rataluminium atom affects foldingISOATXN3 (Homo sapiens)6480464Aluminum affects the folding of ATXN3 protein polymorphismCTDPMID:17300980
Atxn3Rataluminium atom multiple interactionsISOATXN3 (Homo sapiens)6480464Aluminum promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism]CTDPMID:17300980
Atxn3Rataluminium atom multiple interactionsISOAtxn3 (Mus musculus)6480464Aluminum promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism]CTDPMID:17300980
Atxn3Rataluminium(0) affects foldingISOAtxn3 (Mus musculus)6480464Aluminum affects the folding of ATXN3 protein polymorphismCTDPMID:17300980
Atxn3Rataluminium(0) affects foldingISOATXN3 (Homo sapiens)6480464Aluminum affects the folding of ATXN3 protein polymorphismCTDPMID:17300980
Atxn3Rataluminium(0) multiple interactionsISOATXN3 (Homo sapiens)6480464Aluminum promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism]CTDPMID:17300980

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Biological Process
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Atxn3Ratactin cytoskeleton organization acts_upstream_of_or_withinISOATXN3 (Homo sapiens)1624291 PMID:20637808RGDPMID:20637808
Atxn3Ratactin cytoskeleton organization acts_upstream_of_or_withinIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratactin cytoskeleton organization involved_inISSUniProtKB:P542521600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Atxn3Ratcellular response to amino acid starvation involved_inISSUniProtKB:P542521600115GO_REF:0000024UniProtGO_REF:0000024
Atxn3Ratcellular response to amino acid starvation involved_inIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratcellular response to amino acid starvation involved_inISOATXN3 (Homo sapiens)1624291 PMID:33157014RGDPMID:33157014
Atxn3Ratcellular response to heat acts_upstream_of_or_withinISOAtxn3 (Mus musculus)1624291 PMID:19843543RGDPMID:19843543
Atxn3Ratcellular response to heat acts_upstream_of_or_withinIEAUniProtKB:Q9CVD2 and ensembl:ENSMUSP000000216061600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratcellular response to misfolded protein involved_inIEAUniProtKB:Q9CVD2 and ensembl:ENSMUSP000000216061600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratcellular response to misfolded protein involved_inISOAtxn3 (Mus musculus)1624291 PMID:21855799RGDPMID:21855799
Atxn3Ratcellular response to misfolded protein involved_inISSUniProtKB:Q9CVD21600115GO_REF:0000024UniProtGO_REF:0000024
Atxn3Ratexploration behavior acts_upstream_of_or_withinISOAtxn3 (Mus musculus)1624291MGI:3833681 PMID:17764659RGDPMID:17764659
Atxn3Ratexploration behavior acts_upstream_of_or_withinIEAUniProtKB:Q9CVD2 and ensembl:ENSMUSP000000216061600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratintermediate filament cytoskeleton organization acts_upstream_of_or_withinISOATXN3 (Homo sapiens)1624291 PMID:20637808RGDPMID:20637808
Atxn3Ratintermediate filament cytoskeleton organization acts_upstream_of_or_withinIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratintermediate filament cytoskeleton organization involved_inISSUniProtKB:P542521600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Atxn3Ratmicrotubule cytoskeleton organization acts_upstream_of_or_withinISOATXN3 (Homo sapiens)1624291 PMID:20637808RGDPMID:20637808
Atxn3Ratmicrotubule cytoskeleton organization acts_upstream_of_or_withinIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratmicrotubule cytoskeleton organization involved_inISSUniProtKB:P542521600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Atxn3Ratmonoubiquitinated protein deubiquitination involved_inISSUniProtKB:Q9CVD21600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Atxn3Ratcytoplasm located_inISOAtxn3 (Mus musculus)1624291 PMID:17626202 more ...RGDPMID:17626202 more ...
Atxn3Ratcytoplasm located_inIEAUniProtKB:Q9CVD2 and ensembl:ENSMUSP000000216061600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratcytosol located_inIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratcytosol located_inISOATXN3 (Homo sapiens)1624291 PMID:24548080RGDPMID:24548080
Atxn3Ratcytosol located_inISSUniProtKB:P542521600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Atxn3Ratendoplasmic reticulum membrane located_inISOATXN3 (Homo sapiens)1624291 PMID:17000876RGDPMID:17000876
Atxn3Ratendoplasmic reticulum membrane located_inIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratlysosomal membrane is_active_inIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratlysosomal membrane located_inIEAUniProtKB-SubCell:SL-01571600115GO_REF:0000044UniProtGO_REF:0000044
Atxn3Ratlysosomal membrane is_active_inISSUniProtKB:P542521600115GO_REF:0000024UniProtGO_REF:0000024
Atxn3Ratlysosomal membrane is_active_inISOATXN3 (Homo sapiens)1624291 PMID:33157014RGDPMID:33157014
Atxn3Ratlysosome located_inIEAUniProtKB-KW:KW-04581600115GO_REF:0000043UniProtGO_REF:0000043
Atxn3Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Atxn3Ratmitochondrial matrix located_inIEAUniProtKB:Q9CVD2 and ensembl:ENSMUSP000000216061600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratmitochondrial matrix located_inISOAtxn3 (Mus musculus)1624291 PMID:18353661RGDPMID:18353661
Atxn3Ratmitochondrial membrane located_inIEAUniProtKB:Q9CVD2 and ensembl:ENSMUSP000000216061600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratmitochondrial membrane located_inISOAtxn3 (Mus musculus)1624291 PMID:18353661RGDPMID:18353661
Atxn3Ratnuclear inclusion body located_inIEAUniProtKB:Q9CVD2 and ensembl:ENSMUSP000000216061600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratnuclear inclusion body located_inISOAtxn3 (Mus musculus)1624291 PMID:17626202RGDPMID:17626202
Atxn3Ratnuclear matrix located_inIEAUniProtKB-SubCell:SL-01811600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Original Reference(s)
Atxn3RatATPase binding enablesISSUniProtKB:P542521600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Atxn3RatATPase binding enablesIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3RatATPase binding enablesISOATXN3 (Homo sapiens)1624291UniProtKB:P55072 more ...RGDPMID:17000876 and PMID:22970133
Atxn3Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR006155 and InterPro:IPR0338651600115GO_REF:0000002InterProGO_REF:0000002
Atxn3Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:P54252 and ensembl:ENSP000004966951600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.121600115GO_REF:0000003UniProtGO_REF:0000003
Atxn3Ratcysteine-type deubiquitinase activity enablesISOAtxn3 (Mus musculus)1624291 PMID:21855799RGDPMID:21855799
Atxn3Ratcysteine-type deubiquitinase activity enablesIBAMGI:1099442 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Atxn3Ratcysteine-type deubiquitinase activity enablesISSUniProtKB:P542521600115GO_REF:0000024UniProtGO_REF:0000024
Atxn3Ratcysteine-type deubiquitinase activity enablesISOATXN3 (Homo sapiens)1624291 PMID:33157014RGDPMID:33157014
Atxn3Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:Q9CVD2 and ensembl:ENSMUSP000000216061600115GO_REF:0000107EnsemblGO_REF:0000107
Atxn3Ratcysteine-type deubiquitinase activity enablesISSUniProtKB:Q9CVD21600115GO_REF:0000024UniProtGO_REF:0000024
Atxn3Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Atxn3Rathistone deacetylase activity contributes_toIDA 5688291 RGD 
Atxn3Rathistone deacetylase binding  IPIHdac3 (Rattus norvegicus)5688291 RGD 
Atxn3Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Atxn3Rathydrolase activity enablesIEAUniRule:UR0004003001600115GO_REF:0000104UniProtGO_REF:0000104
Atxn3Ratidentical protein binding enablesISSUniProtKB:P54252-11600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
Atxn3Ratidentical protein binding enablesISOATXN3 (Homo sapiens) and UniProtKB:P54252-11624291UniProtKB:P54252-1 more ...RGDPMID:16525503 and PMID:22129356
Atxn3RatK48-linked deubiquitinase activity enablesISSUniProtKB:P542521600115GO_REF:0000024ParkinsonsUK-UCLGO_REF:0000024
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RGD Manual Annotations


  
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Original Reference(s)
Atxn3Ratmitochondrial autophagy pathway   ISOATXN3 (Homo sapiens)10401790 RGD 

Imported Annotations - KEGG (archival)

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Atxn3RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141

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Reference Title
Reference Citation
1. Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease. Alves S, etal., Hum Mol Genet. 2008 Jul 15;17(14):2071-83. Epub 2008 Apr 1.
2. Silencing ataxin-3 mitigates degeneration in a rat model of Machado-Joseph disease: no role for wild-type ataxin-3? Alves S, etal., Hum Mol Genet. 2010 Jun 15;19(12):2380-94. doi: 10.1093/hmg/ddq111. Epub 2010 Mar 22.
3. Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease. Alves S, etal., PLoS One. 2008 Oct 8;3(10):e3341. doi: 10.1371/journal.pone.0003341.
4. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. Beuckmann CT, etal., J Neurosci 2004 May 5;24(18):4469-77.
5. The three 'P's of mitophagy: PARKIN, PINK1, and post-translational modifications. Durcan TM and Fon EA, Genes Dev. 2015 May 15;29(10):989-99. doi: 10.1101/gad.262758.115.
6. Ataxin-3 represses transcription via chromatin binding, interaction with histone deacetylase 3, and histone deacetylation. Evert BO, etal., J Neurosci. 2006 Nov 1;26(44):11474-86.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. CAG expansions in a novel gene for Machado-Joseph disease at chromosome 14q32.1. Kawaguchi Y, etal., Nat Genet. 1994 Nov;8(3):221-8.
9. Characterization of the structure and the amyloidogenic properties of the Josephin domain of the polyglutamine-containing protein ataxin-3. Masino L, etal., J Mol Biol 2004 Dec 3;344(4):1021-35.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Comprehensive gene review and curation RGD comprehensive gene curation
17. Information Derived from GenBank Report RGD, Sept. 2003
18. An isoform of ataxin-3 accumulates in the nucleus of neuronal cells in affected brain regions of SCA3 patients. Schmidt T, etal., Brain Pathol. 1998 Oct;8(4):669-79.
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PMID:10732811   PMID:12486728   PMID:16525503   PMID:17000876   PMID:17626202   PMID:17764659   PMID:18353661   PMID:19542537   PMID:19666135   PMID:19843543   PMID:20347968   PMID:20637808  
PMID:20940148   PMID:21855799   PMID:22129356   PMID:22970133   PMID:24063750   PMID:24068323   PMID:24548080   PMID:25143392   PMID:26880203  



Atxn3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86126,837,107 - 126,872,919 (-)NCBIGRCr8
mRatBN7.26121,072,228 - 121,107,902 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6121,223,964 - 121,257,484 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06121,519,222 - 121,552,743 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06120,855,537 - 120,889,057 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06125,817,420 - 125,853,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6125,819,640 - 125,853,461 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06135,029,278 - 135,065,455 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46126,196,043 - 126,229,844 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16126,199,789 - 126,233,591 (-)NCBI
Celera6118,571,601 - 118,605,060 (-)NCBICelera
Cytogenetic Map6q32NCBI
ATXN3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381492,044,775 - 92,106,582 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1492,044,496 - 92,106,621 (-)EnsemblGRCh38hg38GRCh38
GRCh371492,511,119 - 92,572,926 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361491,598,883 - 91,642,707 (-)NCBINCBI36Build 36hg18NCBI36
Celera1472,577,489 - 72,625,559 (-)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1472,705,822 - 72,754,183 (-)NCBIHuRef
CHM1_11492,463,194 - 92,511,266 (-)NCBICHM1_1
T2T-CHM13v2.01486,274,279 - 86,336,122 (-)NCBIT2T-CHM13v2.0
Atxn3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912101,885,160 - 101,928,139 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12101,885,160 - 101,924,505 (-)EnsemblGRCm39 Ensembl
GRCm3812101,918,901 - 101,959,121 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12101,918,901 - 101,958,246 (-)EnsemblGRCm38mm10GRCm38
MGSCv3712103,157,111 - 103,196,453 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612102,320,604 - 102,359,232 (-)NCBIMGSCv36mm8
Celera12103,135,861 - 103,175,388 (-)NCBICelera
Cytogenetic Map12ENCBI
cM Map1251.32NCBI
Atxn3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543814,405,643 - 14,440,009 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543814,405,415 - 14,443,457 (-)NCBIChiLan1.0ChiLan1.0
ATXN3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21593,222,124 - 93,265,437 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11492,433,581 - 92,481,947 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01472,693,446 - 72,741,772 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11492,041,114 - 92,083,840 (-)NCBIpanpan1.1PanPan1.1panPan2
ATXN3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.181,318,440 - 1,354,814 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl81,247,155 - 1,354,720 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha81,337,255 - 1,373,511 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.081,367,340 - 1,403,659 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl81,367,738 - 1,403,671 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.181,305,295 - 1,341,558 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.081,261,283 - 1,297,915 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.081,382,578 - 1,418,851 (-)NCBIUU_Cfam_GSD_1.0
Atxn3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864013,119,860 - 13,160,641 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936733310,836 - 347,112 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936733306,400 - 347,161 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ATXN3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7113,608,783 - 113,645,841 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17113,611,566 - 113,645,835 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27120,219,165 - 120,253,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ATXN3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12469,810,433 - 69,855,308 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605357,057,799 - 57,105,141 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Atxn3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247348,685,994 - 8,726,329 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Atxn3
70 total Variants

Predicted Target Of
Summary Value
Count of predictions:1288
Count of miRNA genes:348
Interacting mature miRNAs:489
Transcripts:ENSRNOT00000007505
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat

1 to 10 of 23 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 24 of 24 rows
RefSeq Transcripts NM_021702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240486 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240488 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017594338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039112811 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262396 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262397 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063262404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide CH473982 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y12319 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 24 of 24 rows

Ensembl Acc Id: ENSRNOT00000007505   ⟹   ENSRNOP00000007505
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)Ensembl
Rnor_6.0 Ensembl6125,819,640 - 125,853,461 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098027   ⟹   ENSRNOP00000086715
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,074,448 - 121,100,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099444   ⟹   ENSRNOP00000091691
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6121,074,448 - 121,107,902 (-)Ensembl
RefSeq Acc Id: NM_021702   ⟹   NP_067734
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,839,327 - 126,872,781 (-)NCBI
mRatBN7.26121,074,448 - 121,107,902 (-)NCBI
Rnor_6.06125,819,640 - 125,853,461 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
RGSC_v3.46126,196,043 - 126,229,844 (-)RGD
Celera6118,571,601 - 118,605,060 (-)RGD
Sequence:
RefSeq Acc Id: XM_006240485   ⟹   XP_006240547
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240486   ⟹   XP_006240548
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240487   ⟹   XP_006240549
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240488   ⟹   XP_006240550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,904 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240490   ⟹   XP_006240552
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,676 (-)NCBI
mRatBN7.26121,072,228 - 121,107,791 (-)NCBI
Rnor_6.06125,817,420 - 125,853,326 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006240493   ⟹   XP_006240555
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,792 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Rnor_5.06135,029,278 - 135,065,455 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017594337   ⟹   XP_017449826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
mRatBN7.26121,072,228 - 121,107,867 (-)NCBI
Rnor_6.06125,817,420 - 125,853,418 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039112811   ⟹   XP_038968739
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,003 (-)NCBI
mRatBN7.26121,072,228 - 121,107,125 (-)NCBI
RefSeq Acc Id: XM_063262394   ⟹   XP_063118464
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
RefSeq Acc Id: XM_063262395   ⟹   XP_063118465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,904 (-)NCBI
RefSeq Acc Id: XM_063262396   ⟹   XP_063118466
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,771 (-)NCBI
RefSeq Acc Id: XM_063262397   ⟹   XP_063118467
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,676 (-)NCBI
RefSeq Acc Id: XM_063262398   ⟹   XP_063118468
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,502 (-)NCBI
RefSeq Acc Id: XM_063262399   ⟹   XP_063118469
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,873 (-)NCBI
RefSeq Acc Id: XM_063262400   ⟹   XP_063118470
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,837,107 - 126,872,919 (-)NCBI
RefSeq Acc Id: XM_063262401   ⟹   XP_063118471
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,850,550 - 126,872,894 (-)NCBI
RefSeq Acc Id: XM_063262402   ⟹   XP_063118472
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,851,849 - 126,872,771 (-)NCBI
RefSeq Acc Id: XM_063262403   ⟹   XP_063118473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,851,849 - 126,872,771 (-)NCBI
RefSeq Acc Id: XM_063262404   ⟹   XP_063118474
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86126,850,550 - 126,872,789 (-)NCBI
1 to 5 of 23 rows
1 to 5 of 23 rows
RefSeq Acc Id: NP_067734   ⟸   NM_021702
- UniProtKB: O35815 (UniProtKB/Swiss-Prot),   A6JEJ5 (UniProtKB/TrEMBL),   A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240550   ⟸   XM_006240488
- Peptide Label: isoform X5
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240548   ⟸   XM_006240486
- Peptide Label: isoform X3
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240555   ⟸   XM_006240493
- Peptide Label: isoform X6
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006240549   ⟸   XM_006240487
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A6D3 (UniProtKB/TrEMBL)
- Sequence:
Josephin   UIM

Name Modeler Protein Id AA Range Protein Structure
AF-O35815-F1-model_v2 AlphaFold O35815 1-355 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694779
Promoter ID:EPDNEW_R5304
Type:initiation region
Name:Atxn3_1
Description:ataxin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06125,853,368 - 125,853,428EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36463 BioCyc
Ensembl Genes ENSRNOG00000005470 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000007505 ENTREZGENE
  ENSRNOT00000007505.3 UniProtKB/Swiss-Prot
  ENSRNOT00000099444 ENTREZGENE
  ENSRNOT00000151556 ENTREZGENE
Gene3D-CATH 3.90.70.40 UniProtKB/Swiss-Prot
  S15/NS1, RNA-binding UniProtKB/Swiss-Prot
InterPro Ataxin-3 UniProtKB/Swiss-Prot
  Josephin UniProtKB/Swiss-Prot
  UIM_dom UniProtKB/Swiss-Prot
KEGG Report rno:60331 UniProtKB/Swiss-Prot
NCBI Gene 60331 ENTREZGENE
PANTHER ATAXIN-3-RELATED UniProtKB/Swiss-Prot
  PTHR14159 UniProtKB/Swiss-Prot
Pfam Josephin UniProtKB/Swiss-Prot
  SUIM_assoc UniProtKB/Swiss-Prot
  UIM UniProtKB/Swiss-Prot
PhenoGen Atxn3 PhenoGen
PRINTS JOSEPHIN UniProtKB/Swiss-Prot
PROSITE JOSEPHIN UniProtKB/Swiss-Prot
  UIM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000005470 RatGTEx
SMART Josephin UniProtKB/Swiss-Prot
  UIM UniProtKB/Swiss-Prot
UniProt A0A8I6A6D3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GJ61 ENTREZGENE, UniProtKB/TrEMBL
  A6JEJ5 ENTREZGENE, UniProtKB/TrEMBL
  ATX3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Atxn3  ataxin 3  Rsca3  rsca3 protein  Symbol and Name updated 1299863 APPROVED
2002-08-07 Rsca3  rsca3 protein      Symbol and Name status set to provisional 70820 PROVISIONAL