Mapk8 (mitogen-activated protein kinase 8) - Rat Genome Database

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Gene: Mapk8 (mitogen-activated protein kinase 8) Rattus norvegicus
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Symbol: Mapk8
Name: mitogen-activated protein kinase 8
RGD ID: 621506
Description: Enables JUN kinase activity and kinesin binding activity. Involved in several processes, including SMAD protein signal transduction; regulation of apoptotic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within neuronal stem cell population maintenance. Located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Used to study Parkinsonism; alcohol use disorder; brain ischemia; hypertension; and type 2 diabetes mellitus. Biomarker of anti-basement membrane glomerulonephritis; metabolic dysfunction-associated steatotic liver disease; and myocardial infarction. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8); PARTICIPATES IN c-Jun N-terminal kinases MAPK signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; INTERACTS WITH (+)-taxifolin; (-)-anisomycin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: c-Jun N-terminal kinase 1; c-jun NH2-terminal kinase; JNK; MAP kinase 8; MAPK 8; p54 gamma; SAPK gamma; stress-activated protein kinase JNK1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,645,171 - 8,728,225 (-)NCBIGRCr8
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,658,229 - 8,741,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,802,931 - 9,885,718 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,652,731 - 8,735,493 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Mapk8Ratabdominal aortic aneurysm  ISOMapk8 (Mus musculus)1582313 RGD 
Mapk8RatAcute Otitis Media  ISOMapk8 (Mus musculus)150340689mRNA:decreased expression:middle ear (mouse)RGD 
Mapk8Ratalcohol use disorder  IDA 401959334 RGD 
Mapk8RatAlzheimer's disease disease_progressionISOMAPK8 (Homo sapiens)10412676protein:increased expression:brain and CA1 field of hippocampus:RGD 
Mapk8Ratanogenital venereal wart treatmentISOMAPK8 (Homo sapiens)9068941mRNA:increased expression:zone of skin (human)RGDPMID:25774455 and REF_RGD_ID:36174028
Mapk8Ratanti-basement membrane glomerulonephritis  IEP 6218988 RGD 
Mapk8RatArenaviridae infectious disease  ISOMapk8 (Mus musculus)150340679 RGD 
Mapk8Ratbacterial pneumonia severityISOMapk8 (Mus musculus)150340681associated with Escherichia Coli InfectionsRGD 
Mapk8Ratbrain ischemia  IDA 1582325 RGD 
Mapk8Ratcandidiasis amelioratesISOMapk8 (Mus musculus)150340684 RGD 
Mapk8RatCardiomegaly  ISOMapk8 (Mus musculus)1582316 RGD 
Mapk8Ratchronic mucocutaneous candidiasis  ISOMAPK8 (Homo sapiens)150340677associated with connective tissue disease and DNA:splice-site mutation:splice junction:c.311+1G>A (human)RGD 
Mapk8Ratchronic obstructive pulmonary disease severityISOMAPK8 (Homo sapiens)5490968 RGD 
Mapk8Ratchronic obstructive pulmonary disease  ISOMapk8 (Mus musculus)155663371mRNA and protein:increased expression:lung (mouse)RGD 
Mapk8RatColonic Neoplasms  ISOMAPK8 (Homo sapiens)13217412 RGD 
Mapk8RatColonic Neoplasms treatmentISOMAPK8 (Homo sapiens)13217414 RGD 
Mapk8Ratcolorectal adenocarcinoma  ISOMAPK8 (Homo sapiens)13217408 RGD 
Mapk8Ratcolorectal adenoma  ISOMAPK8 (Homo sapiens)13217413 RGD 
Mapk8Ratcolorectal adenoma  ISOMAPK8 (Homo sapiens)13217408 RGD 
Mapk8RatContrast-Induced Nephropathy treatmentIDA 13782262 RGD 
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Original Reference(s)
Mapk8RatCockayne syndrome B  ISOMAPK8 (Homo sapiens)8554872ClinVar Annotator: match by term: Cockayne Syndrome and Type IIClinVarPMID:25741868 and PMID:38177409
Mapk8Ratmegacolon  ISOMAPK8 (Homo sapiens)8554872ClinVar Annotator: match by term: MegacolonClinVarPMID:21681106
Mapk8Ratschizophrenia  ISOMAPK8 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
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Mapk8RatAcute Liver Failure  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17185352
Mapk8RatAnimal Disease Models  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
Mapk8Ratatopic dermatitis  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24046278
Mapk8Ratextrahepatic cholestasis  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
Mapk8RatHyperalgesia  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
Mapk8RatNeoplastic Cell Transformation  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21726611
Mapk8Ratpre-malignant neoplasm  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21317887
Mapk8RatReperfusion Injury  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20302854
Mapk8RatStomach Neoplasms  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18593901
Mapk8Rattrigeminal neuralgia  ISOMAPK8 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27093858
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1 to 20 of 1241 rows

  
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Original Reference(s)
Mapk8Rat(+)-pilocarpine multiple interactionsISOMAPK8 (Homo sapiens)64804641 more ...CTDPMID:19927300
Mapk8Rat(+)-pilocarpine increases activityISOMAPK8 (Homo sapiens)6480464Pilocarpine results in increased activity of MAPK8 proteinCTDPMID:19927300
Mapk8Rat(+)-taxifolin multiple interactionsISOMAPK8 (Homo sapiens)6480464taxifolin inhibits the reaction [IFNG protein results in increased phosphorylation of MAPK8 protein]CTDPMID:12044887
Mapk8Rat(+)-taxifolin multiple interactionsEXP 6480464taxifolin inhibits the reaction [Colistin results in increased activity of MAPK8 protein]CTDPMID:33882723
Mapk8Rat(-)-anisomycin increases activityISOMAPK8 (Homo sapiens)6480464Anisomycin results in increased activity of MAPK8 proteinCTDPMID:12902192
Mapk8Rat(-)-anisomycin multiple interactionsISOMAPK8 (Homo sapiens)6480464Anisomycin inhibits the reaction [1-hydroxyalantolactone inhibits the reaction [TGFB1 protein results in increased phosphorylation of MAPK8 protein]] more ...CTDPMID:15737997 more ...
Mapk8Rat(-)-anisomycin increases phosphorylationISOMapk8 (Mus musculus)6480464Anisomycin results in increased phosphorylation of MAPK8 proteinCTDPMID:15772366 and PMID:16038797
Mapk8Rat(-)-anisomycin multiple interactionsEXP 6480464Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 proteinCTDPMID:15961565
Mapk8Rat(-)-anisomycin multiple interactionsISOMapk8 (Mus musculus)64804644-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3 and 4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK8 protein]CTDPMID:15772366
Mapk8Rat(-)-anisomycin increases phosphorylationISOMAPK8 (Homo sapiens)6480464Anisomycin results in increased phosphorylation of MAPK8 proteinCTDPMID:12967334 and PMID:33075463
Mapk8Rat(-)-Arctigenin multiple interactionsISOMapk8 (Mus musculus)6480464arctigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]CTDPMID:21048310
Mapk8Rat(-)-citrinin increases phosphorylationISOMAPK8 (Homo sapiens)6480464Citrinin results in increased phosphorylation of MAPK8 proteinCTDPMID:19361540
Mapk8Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMAPK8 (Homo sapiens)6480464epigallocatechin gallate inhibits the reaction [[Paclitaxel co-treated with F2 protein] results in increased phosphorylation of MAPK8 protein] and epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased phosphorylation of MAPK8 protein]CTDPMID:19944065 and PMID:31252129
Mapk8Rat(-)-epigallocatechin 3-gallate decreases expressionISOMAPK8 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of MAPK8 proteinCTDPMID:35218280
Mapk8Rat(-)-epigallocatechin 3-gallate increases activityISOMAPK8 (Homo sapiens)6480464epigallocatechin gallate results in increased activity of MAPK8 proteinCTDPMID:15705601
Mapk8Rat(-)-matairesinol multiple interactionsISOMapk8 (Mus musculus)6480464matairesinol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]CTDPMID:21048310
Mapk8Rat(1->4)-beta-D-glucan multiple interactionsISOMapk8 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of MAPK8 mRNACTDPMID:36331819
Mapk8Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of MAPK8 mRNACTDPMID:23830814
Mapk8Rat(R)-noradrenaline multiple interactionsEXP 6480464Acetylcysteine inhibits the reaction [Norepinephrine results in increased phosphorylation of MAPK8 protein]CTDPMID:17041759
Mapk8Rat(R)-noradrenaline increases phosphorylationEXP 6480464Norepinephrine results in increased phosphorylation of MAPK8 proteinCTDPMID:17041759

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Biological Process
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Mapk8Ratapoptotic signaling pathway acts_upstream_ofISOMapk8 (Mus musculus)1624291MGI:1346862 PMID:16458303RGDPMID:16458303
Mapk8Ratautophagy acts_upstream_of_or_withinISOMapk8 (Mus musculus)1624291 PMID:25891078RGDPMID:25891078
Mapk8Ratcellular response to amino acid starvation involved_inIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Ratcellular response to amino acid starvation involved_inISOMAPK8 (Homo sapiens)1624291 PMID:11096076RGDPMID:11096076
Mapk8Ratcellular response to amyloid-beta  IEP 10412678 RGD 
Mapk8Ratcellular response to hydrogen peroxide acts_upstream_of_or_withinISOMapk8 (Mus musculus)1624291 PMID:20808772RGDPMID:20808772
Mapk8Ratcellular response to interleukin-1  IEP 10412698 RGD 
Mapk8Ratcellular response to lipopolysaccharide acts_upstream_of_or_withinISOMAPK8 (Homo sapiens)1624291 PMID:23776175RGDPMID:23776175
Mapk8Ratcellular response to lipopolysaccharide acts_upstream_of_or_withinIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Ratcellular response to mechanical stimulus involved_inIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Ratcellular response to mechanical stimulus involved_inISOMAPK8 (Homo sapiens)1624291 PMID:19593445RGDPMID:19593445
Mapk8Ratcellular response to nitric oxide acts_upstream_of_or_withinISOMapk8 (Mus musculus)1624291 PMID:18007661RGDPMID:18007661
Mapk8Ratcellular response to oxidative stress involved_inISOMAPK8 (Homo sapiens)1624291 PMID:27568560RGDPMID:27568560
Mapk8Ratcellular response to oxidative stress involved_inIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Ratcellular response to oxygen-glucose deprivation  IEP 329853763protein:increased expression:neuronal PC12 cells ratRGD 
Mapk8Ratcellular response to oxygen-glucose deprivation  IMP 329853763 RGD 
Mapk8Ratcellular response to reactive oxygen species involved_inIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Ratcellular response to reactive oxygen species involved_inISOMAPK8 (Homo sapiens)1624291 PMID:34048572RGDPMID:34048572
Mapk8Ratdendrite morphogenesis involved_inISOMapk8 (Mus musculus)1624291 PMID:16000625RGDPMID:16000625
Mapk8Ratenergy homeostasis acts_upstream_of_or_withinISOMapk8 (Mus musculus)1624291 PMID:36977414RGDPMID:36977414
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Cellular Component
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Original Reference(s)
Mapk8Rataxon  IDA 2293331axon cytoplasmRGD 
Mapk8Rataxon located_inISOMapk8 (Mus musculus)1624291 PMID:22683681RGDPMID:22683681
Mapk8Ratbasal dendrite located_inISOMapk8 (Mus musculus)1624291 PMID:22683681RGDPMID:22683681
Mapk8Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Mapk8Ratcytoplasm located_inISOMapk8 (Mus musculus)1624291 PMID:15030387 more ...RGDPMID:15030387 more ...
Mapk8Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Mapk8Ratcytoplasm is_active_inISOMapk8 (Mus musculus)1624291 PMID:29078390 and PMID:36812915RGDPMID:29078390 and PMID:36812915
Mapk8Ratcytoplasm is_active_inIBACGD:CAL0000197240 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk8Ratcytosol located_inTAS 1600115Reactome:R-RNO-205027ReactomeReactome:R-RNO-205027
Mapk8Ratcytosol located_inISOMapk8 (Mus musculus)1624291 PMID:11884367RGDPMID:11884367
Mapk8Ratcytosol located_inTAS 1600115Reactome:R-RNO-209184ReactomeReactome:R-RNO-209184
Mapk8Ratdendrite cytoplasm  IDA 2293331 RGD 
Mapk8Ratmitochondrion located_inISOMapk8 (Mus musculus)1624291 PMID:11884367RGDPMID:11884367
Mapk8Ratneuron projection located_inISOMapk8 (Mus musculus)1624291 PMID:29078390RGDPMID:29078390
Mapk8Ratnucleoplasm located_inTAS 1600115Reactome:R-RNO-209184ReactomeReactome:R-RNO-209184
Mapk8Ratnucleoplasm located_inISOMAPK8 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Mapk8Ratnucleoplasm located_inIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Ratnucleus is_active_inIBACGD:CAL0000197240 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk8Ratnucleus located_inIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Mapk8RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Mapk8RatATP binding enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mapk8RatATP binding enablesIEAUniRule:UR0015287581600115GO_REF:0000104UniProtGO_REF:0000104
Mapk8Ratenzyme binding enablesISOMAPK8 (Homo sapiens)1624291UniProtKB:P12821 and PMID:14615289RGDPMID:14615289
Mapk8Ratenzyme binding enablesIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Rathistone deacetylase binding enablesISOMAPK8 (Homo sapiens)1624291UniProtKB:Q96EB6 and PMID:20027304RGDPMID:20027304
Mapk8Rathistone deacetylase binding enablesIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Rathistone deacetylase regulator activity enablesIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8Rathistone deacetylase regulator activity enablesISOMAPK8 (Homo sapiens)1624291 PMID:20027304RGDPMID:20027304
Mapk8RatJUN kinase activity  IDA 2298565 RGD 
Mapk8RatJUN kinase activity  TAS 625500 RGD 
Mapk8RatJUN kinase activity  IDA 2298577 RGD 
Mapk8RatJUN kinase activity enablesIEAUniProtKB:P45983 and ensembl:ENSP000003633041600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk8RatJUN kinase activity enablesISOMapk8 (Mus musculus)1624291 PMID:10811224 more ...RGDPMID:10811224 more ...
Mapk8RatJUN kinase activity enablesIBAFB:FBgn0000229 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk8RatJUN kinase activity enablesIEAARBA:ARBA000355601600115GO_REF:0000117UniProtGO_REF:0000117
Mapk8RatJUN kinase activity enablesISOMAPK8 (Homo sapiens)1624291 PMID:21095239 and PMID:8654373RGDPMID:21095239 and PMID:8654373
Mapk8RatJUN kinase activity enablesISSUniProtKB:Q91Y861600115GO_REF:0000024UniProtGO_REF:0000024
Mapk8Ratkinase activity enablesISOMapk8 (Mus musculus)1624291 PMID:12808090 more ...RGDPMID:12808090 more ...
Mapk8Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  

Imported Annotations - SMPDB

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Original Reference(s)
Mapk8Ratadenosine signaling pathway  ISOMAPK8 (Homo sapiens)10402751 SMPDBSMP:00321
Mapk8Ratadenosine signaling pathway  ISOMAPK8 (Homo sapiens)10402751 SMPDBSMP:00320
Mapk8RatFc epsilon receptor mediated signaling pathway  ISOMAPK8 (Homo sapiens)10402751 SMPDBSMP:00358

Imported Annotations - KEGG (archival)

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Mapk8Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Mapk8RatChagas disease pathway  IEA 6907045 KEGGrno:05142
Mapk8Ratcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
Mapk8RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141
Mapk8Ratepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
Mapk8RatFc epsilon receptor mediated signaling pathway  IEA 6907045 KEGGrno:04664
Mapk8Ratgonadotropin-releasing hormone signaling pathway  IEA 6907045 KEGGrno:04912
Mapk8Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Mapk8Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Mapk8Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Mapk8Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
Mapk8Ratneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722
Mapk8RatNOD-like receptor signaling pathway  IEA 6907045 KEGGrno:04621
Mapk8Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
Mapk8RatRetinoic acid-inducible gene (RIG) I-like receptor signaling pathway  IEA 6907045 KEGGrno:04622
Mapk8RatToll-like receptor signaling pathway   IEA 6907045 KEGGrno:04620
Mapk8Rattoxoplasmosis pathway  IEA 6907045 KEGGrno:05145
Mapk8Rattuberculosis pathway  IEA 6907045 KEGGrno:05152
Mapk8Rattype 2 diabetes mellitus pathway   IEA 6907045 KEGGrno:04930
Mapk8RatWnt signaling pathway  IEA 6907045 KEGGrno:04310
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Imported Annotations - PID (archival)

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Original Reference(s)
Mapk8Ratceramide signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200119
Mapk8Ratendothelin signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200005
Mapk8Ratephrin - ephrin receptor bidirectional signaling axis  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200204
Mapk8Raterythropoietin signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200183
Mapk8RatFasL mediated signaling pathway   ISOMAPK8 (Homo sapiens)6484113 PIDPID:200080
Mapk8Ratglypican signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200225
Mapk8Ratinterleukin-1 signaling pathway   ISOMAPK8 (Homo sapiens)6484113 PIDPID:200089
Mapk8Ratinterleukin-2 signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200098
Mapk8RatN-cadherin signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200209
Mapk8Ratp53 signaling pathway   ISOMAPK8 (Homo sapiens)6484113 PIDPID:200206
Mapk8Ratplatelet-derived growth factor signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200149
Mapk8RatReelin signaling pathway   ISOMAPK8 (Homo sapiens)6484113 PIDPID:200062
Mapk8Ratsphingosine 1-phosphate signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200211
Mapk8Ratsyndecan signaling pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200192
Mapk8RatTrail mediated signaling pathway   ISOMAPK8 (Homo sapiens)6484113 PIDPID:200068
Mapk8RatWnt signaling, non-canonical pathway  ISOMAPK8 (Homo sapiens)6484113 PIDPID:200020
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Reference Title
Reference Citation
1. c-Jun NH(2)-terminal kinase (JNK)1 and JNK2 signaling pathways have divergent roles in CD8(+) T cell-mediated antiviral immunity. Arbour N, etal., J Exp Med. 2002 Apr 1;195(7):801-10. doi: 10.1084/jem.20011481.
2. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer KL, etal., Mol Biol Cell. 1998 Mar;9(3):561-73.
3. Capture of Dense Core Vesicles at Synapses by JNK-Dependent Phosphorylation of Synaptotagmin-4. Bharat V, etal., Cell Rep. 2017 Nov 21;21(8):2118-2133. doi: 10.1016/j.celrep.2017.10.084.
4. Selenium and sulindac are synergistic to inhibit intestinal tumorigenesis in Apc/p21 mice. Bi X, etal., J Hematol Oncol. 2013 Jan 17;6:8. doi: 10.1186/1756-8722-6-8.
5. Stress- and cell type-dependent regulation of transfected c-Jun N-terminal kinase and mitogen-activated protein kinase kinase isoforms. Butterfield L, etal., Biochem J. 1999 Mar 15;338 ( Pt 3):681-6.
6. Activation of c-Jun NH2-terminal kinases by interleukin-1 beta in normal human osteoblastic and rat UMR-106 cells. Chaudhary LR and Avioli LV, J Cell Biochem. 1998 Apr 1;69(1):87-93.
7. Vaccinia-related kinase 2 blunts sorafenib's efficacy against hepatocellular carcinoma by disturbing the apoptosis-autophagy balance. Chen S, etal., Oncogene. 2021 May;40(19):3378-3393. doi: 10.1038/s41388-021-01780-y. Epub 2021 Apr 19.
8. Toll-like receptor 2-mediated sequential activation of MyD88 and MAPKs contributes to lipopolysaccharide-induced sp-a gene expression in human alveolar epithelial cells. Chuang CY, etal., Immunobiology. 2011 Jun;216(6):707-14. doi: 10.1016/j.imbio.2010.10.009. Epub 2010 Nov 4.
9. Intermittent ischemia reduces warm hypoxia-reoxygenation-induced JNK(1)/SAPK(1) activation and apoptosis in rat hepatocytes. Crenesse D, etal., Hepatology. 2001 Nov;34(5):972-8.
10. Haematopoietic cell-derived Jnk1 is crucial for chronic inflammation and carcinogenesis in an experimental model of liver injury. Cubero FJ, etal., J Hepatol. 2015 Jan;62(1):140-9. doi: 10.1016/j.jhep.2014.08.029. Epub 2014 Aug 27.
11. JNK inhibition reduces apoptosis and neovascularization in a murine model of age-related macular degeneration. Du H, etal., Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2377-82. doi: 10.1073/pnas.1221729110. Epub 2013 Jan 22.
12. JNK2 translocates to the mitochondria and mediates cytochrome c release in PC12 cells in response to 6-hydroxydopamine. Eminel S, etal., J Biol Chem. 2004 Dec 31;279(53):55385-92. Epub 2004 Oct 25.
13. p38 and JNK have distinct regulatory functions on the development of apoptosis during simulated ischaemia and reperfusion in neonatal cardiomyocytes. Engelbrecht AM, etal., Basic Res Cardiol. 2004 Sep;99(5):338-50. Epub 2004 Jun 14.
14. Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system. Flood DG, etal., J Comp Neurol. 1998 Aug 31;398(3):373-92.
15. A role for c-Jun N-terminal kinase 1 (JNK1), but not JNK2, in the beta-amyloid-mediated stabilization of protein p53 and induction of the apoptotic cascade in cultured cortical neurons. Fogarty MP, etal., Biochem J. 2003 May 1;371(Pt 3):789-98.
16. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. Gao Z, etal., J Biol Chem. 2011 Jun 24;286(25):22227-34. doi: 10.1074/jbc.M111.228874. Epub 2011 May 3.
17. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
18. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
19. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Guma M, etal., Proc Natl Acad Sci U S A. 2009 May 26;106(21):8760-5. doi: 10.1073/pnas.0902659106. Epub 2009 May 11.
20. c-Jun N-terminal kinase is required for metalloproteinase expression and joint destruction in inflammatory arthritis. Han Z, etal., J Clin Invest. 2001 Jul;108(1):73-81.
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PMID:8654373   PMID:8889548   PMID:9516415   PMID:9710592   PMID:10811224   PMID:11096076   PMID:11146548   PMID:11884367   PMID:12376548   PMID:12445686   PMID:12606754   PMID:12700162  
PMID:12808090   PMID:12865320   PMID:12869386   PMID:12869527   PMID:12933347   PMID:12971962   PMID:14615289   PMID:14633134   PMID:14643766   PMID:14769808   PMID:14967141   PMID:14983993  
PMID:15030387   PMID:15093613   PMID:15145937   PMID:15254243   PMID:15316358   PMID:15326485   PMID:15356200   PMID:15483136   PMID:15579909   PMID:15591151   PMID:15689551   PMID:15739188  
PMID:15767678   PMID:15820682   PMID:15850461   PMID:15911351   PMID:16000625   PMID:16005241   PMID:16055088   PMID:16092944   PMID:16157589   PMID:16246848   PMID:16260609   PMID:16336220  
PMID:16396984   PMID:16458303   PMID:16491099   PMID:16491125   PMID:16771680   PMID:16902157   PMID:16942465   PMID:16971530   PMID:17003331   PMID:17015265   PMID:17041759   PMID:17251057  
PMID:17287517   PMID:17325051   PMID:17333127   PMID:17410600   PMID:17519787   PMID:17521827   PMID:17542038   PMID:17546627   PMID:17555943   PMID:17583725   PMID:17668873   PMID:17698050  
PMID:17723265   PMID:17923323   PMID:17923327   PMID:17932215   PMID:17959308   PMID:18007661   PMID:18023197   PMID:18056745   PMID:18060575   PMID:18096574   PMID:18206660   PMID:18222916  
PMID:18316368   PMID:18330891   PMID:18351465   PMID:18355160   PMID:18371080   PMID:18455449   PMID:18547751   PMID:18566605   PMID:18625195   PMID:18650245   PMID:18666320   PMID:18782186  
PMID:18800014   PMID:18806094   PMID:18822271   PMID:18926830   PMID:18957384   PMID:19011585   PMID:19061880   PMID:19080378   PMID:19099816   PMID:19109696   PMID:19272379   PMID:19289495  
PMID:19332546   PMID:19362079   PMID:19368836   PMID:19430970   PMID:19460707   PMID:19593445   PMID:19648647   PMID:19723053   PMID:19723098   PMID:19776350   PMID:19819946   PMID:19840222  
1 to 10 of 21 rows



Mapk8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8168,645,171 - 8,728,225 (-)NCBIGRCr8
mRatBN7.2168,638,897 - 8,721,960 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl168,638,924 - 8,721,981 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx168,658,229 - 8,741,022 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0169,802,931 - 9,885,718 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0168,652,731 - 8,735,493 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0169,620,854 - 9,709,342 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl169,625,177 - 9,709,347 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01611,579,503 - 11,662,858 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4168,925,133 - 9,004,897 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1168,925,181 - 9,004,945 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBICelera
Cytogenetic Map16p16NCBI
MAPK8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381048,306,677 - 48,439,360 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1048,306,639 - 48,439,360 (+)EnsemblGRCh38hg38GRCh38
GRCh371049,514,720 - 49,647,403 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361049,279,693 - 49,313,189 (+)NCBINCBI36Build 36hg18NCBI36
Build 341049,279,692 - 49,313,189NCBI
Celera1043,195,579 - 43,229,096 (+)NCBICelera
Cytogenetic Map10q11.22NCBI
HuRef1043,779,561 - 43,912,232 (+)NCBIHuRef
CHM1_11049,796,560 - 49,929,236 (+)NCBICHM1_1
T2T-CHM13v2.01049,155,699 - 49,288,442 (+)NCBIT2T-CHM13v2.0
Mapk8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391433,099,855 - 33,169,213 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1433,099,855 - 33,169,115 (-)EnsemblGRCm39 Ensembl
GRCm381433,377,898 - 33,447,353 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1433,377,898 - 33,447,158 (-)EnsemblGRCm38mm10GRCm38
MGSCv371434,191,084 - 34,260,344 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361432,211,101 - 32,276,249 (-)NCBIMGSCv36mm8
Celera1429,636,611 - 29,705,910 (-)NCBICelera
Cytogenetic Map14BNCBI
cM Map1420.22NCBI
Mapk8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555561,593,494 - 1,665,784 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555561,593,552 - 1,705,543 (-)NCBIChiLan1.0ChiLan1.0
MAPK8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2860,574,189 - 60,702,156 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11060,579,543 - 60,707,592 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01045,806,748 - 45,936,362 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAPK8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.128323,361 - 410,367 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl28368,513 - 406,401 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha28552,432 - 639,965 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.028498,642 - 586,320 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl28498,626 - 586,317 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.128298,436 - 386,002 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.028339,385 - 427,241 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.028432,766 - 552,601 (+)NCBIUU_Cfam_GSD_1.0
Mapk8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721380,572,918 - 80,691,087 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367281,775,641 - 1,893,907 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367281,775,746 - 1,893,895 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1488,988,949 - 89,108,874 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11488,988,914 - 89,108,875 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21496,724,970 - 96,803,101 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1943,356,603 - 43,489,066 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl943,356,308 - 43,393,425 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660483,124,408 - 3,258,374 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249281,439,146 - 1,494,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249281,442,216 - 1,494,275 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mapk8
607 total Variants

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:118
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000065216
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
1357403Slep4Serum leptin concentration QTL 43.91blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1619639137Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat

1 to 10 of 30 rows
STS-L26318  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,643,214 - 8,643,351 (+)MAPPERmRatBN7.2
Rnor_6.0169,625,172 - 9,625,308NCBIRnor6.0
Rnor_5.01611,583,821 - 11,583,957UniSTSRnor5.0
RGSC_v3.4168,925,128 - 8,925,264UniSTSRGSC3.4
Celera166,563,984 - 6,564,120UniSTS
Cytogenetic Map16p16UniSTS
RH129367  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,639,061 - 8,639,268 (+)MAPPERmRatBN7.2
Rnor_6.0169,621,019 - 9,621,225NCBIRnor6.0
Rnor_5.01611,579,668 - 11,579,874UniSTSRnor5.0
RGSC_v3.4168,920,975 - 8,921,181UniSTSRGSC3.4
Celera166,568,017 - 6,568,223UniSTS
RH 3.4 Map1686.3UniSTS
Cytogenetic Map16p16UniSTS
AI849689  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,638,957 - 8,639,041 (+)MAPPERmRatBN7.2
Rnor_6.0169,620,915 - 9,620,998NCBIRnor6.0
Rnor_5.01611,579,564 - 11,579,647UniSTSRnor5.0
RGSC_v3.4168,920,871 - 8,920,954UniSTSRGSC3.4
Celera166,568,244 - 6,568,327UniSTS
Cytogenetic Map16p16UniSTS
RH143559  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,721,332 - 8,721,441 (+)MAPPERmRatBN7.2
Rnor_6.0169,708,715 - 9,708,823NCBIRnor6.0
Rnor_5.01611,662,231 - 11,662,339UniSTSRnor5.0
RGSC_v3.4169,004,320 - 9,004,428UniSTSRGSC3.4
Celera166,486,111 - 6,486,219UniSTS
RH 3.4 Map1685.6UniSTS
Cytogenetic Map16p16UniSTS
RH139074  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,638,992 - 8,639,125 (+)MAPPERmRatBN7.2
Rnor_6.0169,620,950 - 9,621,082NCBIRnor6.0
Rnor_5.01611,579,599 - 11,579,731UniSTSRnor5.0
RGSC_v3.4168,920,906 - 8,921,038UniSTSRGSC3.4
Celera166,568,160 - 6,568,292UniSTS
RH 3.4 Map1686.3UniSTS
Cytogenetic Map16p16UniSTS
RH140683  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8168,716,011 - 8,716,208 (+)Marker Load Pipeline
mRatBN7.2168,709,744 - 8,709,941 (+)MAPPERmRatBN7.2
Rnor_6.0169,697,129 - 9,697,325NCBIRnor6.0
Rnor_5.01611,650,645 - 11,650,841UniSTSRnor5.0
RGSC_v3.4168,992,733 - 8,992,929UniSTSRGSC3.4
Celera166,497,603 - 6,497,799UniSTS
RH 3.4 Map1687.9UniSTS
Cytogenetic Map16p16UniSTS
UniSTS:237161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2168,639,728 - 8,640,023 (+)MAPPERmRatBN7.2
Rnor_6.0169,621,686 - 9,621,980NCBIRnor6.0
Rnor_5.01611,580,335 - 11,580,629UniSTSRnor5.0
RGSC_v3.4168,921,642 - 8,921,936UniSTSRGSC3.4
Celera166,567,262 - 6,567,556UniSTS
Cytogenetic Map16p16UniSTS
MARC_13424-13425:1002294866:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8168,653,964 - 8,654,574 (+)Marker Load Pipeline
mRatBN7.2168,647,690 - 8,648,300 (+)MAPPERmRatBN7.2
Rnor_6.0169,629,648 - 9,630,257NCBIRnor6.0
Rnor_5.01611,588,297 - 11,588,906UniSTSRnor5.0
RGSC_v3.4168,929,604 - 8,930,213UniSTSRGSC3.4
Celera166,559,083 - 6,559,692UniSTS
Cytogenetic Map16p16UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000065216   ⟹   ENSRNOP00000062048
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,643,220 - 8,721,960 (-)Ensembl
Rnor_6.0 Ensembl169,625,177 - 9,658,484 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083933   ⟹   ENSRNOP00000075277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,642,937 - 8,721,981 (-)Ensembl
Rnor_6.0 Ensembl169,640,480 - 9,709,347 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000099742   ⟹   ENSRNOP00000082511
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,638,924 - 8,721,960 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000101766   ⟹   ENSRNOP00000096591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl168,638,924 - 8,721,960 (-)Ensembl
RefSeq Acc Id: NM_053829   ⟹   NP_446281
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8168,645,171 - 8,728,225 (-)NCBI
mRatBN7.2168,638,897 - 8,721,960 (-)NCBI
Rnor_6.0169,620,854 - 9,709,342 (-)NCBI
Rnor_5.01611,579,503 - 11,662,858 (-)NCBI
Celera166,485,592 - 6,568,388 (+)NCBI
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_446281 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA42111 (Get FASTA)   NCBI Sequence Viewer  
  ABX46062 (Get FASTA)   NCBI Sequence Viewer  
  AIZ76559 (Get FASTA)   NCBI Sequence Viewer  
  EDL88899 (Get FASTA)   NCBI Sequence Viewer  
  EDL88900 (Get FASTA)   NCBI Sequence Viewer  
  EDL88901 (Get FASTA)   NCBI Sequence Viewer  
  EDL88902 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000082511
GenBank Protein P49185 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_446281   ⟸   NM_053829
- UniProtKB: P49185 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000062048   ⟸   ENSRNOT00000065216
Ensembl Acc Id: ENSRNOP00000075277   ⟸   ENSRNOT00000083933
Ensembl Acc Id: ENSRNOP00000082511   ⟸   ENSRNOT00000099742
Ensembl Acc Id: ENSRNOP00000096591   ⟸   ENSRNOT00000101766
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P49185-F1-model_v2 AlphaFold P49185 1-411 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699958
Promoter ID:EPDNEW_R10474
Type:multiple initiation site
Name:Mapk8_1
Description:mitogen-activated protein kinase 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0169,709,355 - 9,709,415EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-12092 BioCyc
Ensembl Genes ENSRNOG00000020155 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000099742 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_JNK UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:116554 UniProtKB/Swiss-Prot
NCBI Gene 116554 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB MAPK8 RGD
PhenoGen Mapk8 PhenoGen
PRINTS JNKMAPKINASE UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020155 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A0G2KA63_RAT UniProtKB/TrEMBL
  A0A8I5ZXC7_RAT UniProtKB/TrEMBL
  A0A8I6B4F5_RAT UniProtKB/TrEMBL
  A6KFU2_RAT UniProtKB/TrEMBL
  A6KFU3_RAT UniProtKB/TrEMBL
  A6KFU4_RAT UniProtKB/TrEMBL
  A6KFU5_RAT UniProtKB/TrEMBL
  F1LP66_RAT UniProtKB/TrEMBL
  MK08_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Mapk8  mitogen-activated protein kinase 8      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mapk8  mitogen-activated protein kinase 8      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_regulation activated by cellular stress, sphingomyelinase and tumour necrosis factor (TNF)-alpha 729029