Ikbkb (inhibitor of nuclear factor kappa B kinase subunit beta) - Rat Genome Database

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Gene: Ikbkb (inhibitor of nuclear factor kappa B kinase subunit beta) Rattus norvegicus
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Symbol: Ikbkb
Name: inhibitor of nuclear factor kappa B kinase subunit beta
RGD ID: 621375
Description: Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta); PARTICIPATES IN adenosine signaling pathway; FasL mediated signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AIM-1; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of kappaB kinase beta; inhibitor of nuclear factor kappa B kinase beta subunit; inhibitor of nuclear factor kappa-B kinase subunit beta; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta; serine/threonine protein kinase IKBKB
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,021,968 - 76,075,717 (+)NCBIGRCr8
mRatBN7.21669,319,487 - 69,373,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,593,277 - 74,646,961 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,025,765 - 78,078,546 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,274,913 - 73,327,717 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,177,233 - 74,230,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,177,215 - 74,230,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,809,854 - 73,863,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,804,730 - 73,858,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,805,346 - 73,858,348 (+)NCBI
Celera1667,214,025 - 67,266,348 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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IkbkbRatAlzheimer's disease treatmentIEP 10045941protein:increased expression:hippocampus:RGD 
IkbkbRatbreast cancer susceptibilityISOIKBKB (Homo sapiens)6484541DNA:SNPs: :multipleRGD 
IkbkbRatChoroidal Neovascularization treatmentISOIkbkb (Mus musculus)10045942 RGD 
IkbkbRatcolitis treatmentIEP 2298659 RGD 
IkbkbRatcolon cancer  IEP 7495781associated with Obesity and protein:increased expression:large intestine mucosa RGD 
IkbkbRatdermatitis  ISOIkbkb (Mus musculus)7495756 RGD 
IkbkbRatdermatitis  ISOIKBKB (Homo sapiens)7495759 RGD 
IkbkbRatExperimental Arthritis  IMP 7495778 RGD 
IkbkbRatExperimental Arthritis treatmentISOIkbkb (Mus musculus)7495772 RGD 
IkbkbRatExperimental Diabetes Mellitus  IDA 7495777protein:increased phosphorylation:liverRGD 
IkbkbRatExperimental Melanoma  ISOIKBKB (Homo sapiens)7495758 RGD 
IkbkbRatHyperplasia  IMP 7495757 RGD 
IkbkbRathypertension treatmentIEP 7495780 RGD 
IkbkbRatinflammatory bowel disease treatmentISOIkbkb (Mus musculus)7495770 RGD 
IkbkbRatInsulin Resistance treatmentIEP 7495768 RGD 
IkbkbRatKidney Reperfusion Injury treatmentIMP 7495779 RGD 
IkbkbRatliver cancer  ISOIKBKB (Homo sapiens)153305911human cells in mouse modelRGD 
IkbkbRatmiddle cerebral artery infarction treatmentISOIkbkb (Mus musculus)10045955 RGD 
IkbkbRatmuscular atrophy treatmentIMP 7495773 RGD 
IkbkbRatobesity  ISOIkbkb (Mus musculus)10045952protein:increased expression:liver:RGD 
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IkbkbRatgenetic disease  ISOIKBKB (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
IkbkbRatHirschsprung's disease  ISOIKBKB (Homo sapiens)8554872ClinVar Annotator: match by term: Hirschsprung diseaseClinVarPMID:28492532
IkbkbRatIMMUNODEFICIENCY 15  ISOIKBKB (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 15ClinVarPMID:10195897 more ...
IkbkbRatimmunodeficiency 15A  ISOIKBKB (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 15aClinVarPMID:24033266 more ...
IkbkbRatimmunodeficiency 15B  ISOIKBKB (Homo sapiens)8554872ClinVar Annotator: match by term: IMMUNODEFICIENCY 15BClinVarPMID:10195897 more ...
IkbkbRatsevere combined immunodeficiency  ISOIKBKB (Homo sapiens)8554872ClinVar Annotator: match by term: Severe combined immunodeficiency diseaseClinVar 
IkbkbRattorsion dystonia 6  ISOIKBKB (Homo sapiens)8554872ClinVar Annotator: match by term: Torsion dystonia 6ClinVarPMID:28492532
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IkbkbRatglucose intolerance  ISOIKBKB (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:31095431
IkbkbRathypertension  ISOIKBKB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27659729 and PMID:32147540
IkbkbRatInflammation  ISOIKBKB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29036520
IkbkbRatInsulin Resistance  ISOIKBKB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29036520
IkbkbRatNeonatal Hyperbilirubinemia  ISOIKBKB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28167773
IkbkbRatpneumonia  ISOIKBKB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31095431
IkbkbRatvascular disease  ISOIKBKB (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29036520
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IkbkbRatimmunodeficiency 15A  ISSIkbkb (Mus musculus)13592920OMIM:618204MouseDO 
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IkbkbRatimmunodeficiency 15A  ISOIKBKB (Homo sapiens)7240710 OMIM 
IkbkbRatimmunodeficiency 15B  ISOIKBKB (Homo sapiens)7240710 OMIM 

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IkbkbRat(+)-artemisinin multiple interactionsISOIKBKB (Homo sapiens)6480464artemisinin inhibits the reaction [Simvastatin results in increased phosphorylation of IKBKB protein]CTDPMID:18463201
IkbkbRat(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [Rotenone results in increased expression of IKBKB mRNA]CTDPMID:35337893
IkbkbRat(-)-epigallocatechin 3-gallate multiple interactionsISOIKBKB (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of IKBKB mRNACTDPMID:22079256
IkbkbRat(-)-epigallocatechin 3-gallate decreases expressionEXP 6480464epigallocatechin gallate results in decreased expression of IKBKB protein modified formCTDPMID:27659729
IkbkbRat(1->4)-beta-D-glucan multiple interactionsISOIkbkb (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of IKBKB mRNACTDPMID:36331819
IkbkbRat(R,R,R)-alpha-tocopherol multiple interactionsISOIKBKB (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of IKBKB protein]CTDPMID:34310962
IkbkbRat(S)-colchicine increases phosphorylationISOIKBKB (Homo sapiens)6480464Colchicine results in increased phosphorylation of IKBKB proteinCTDPMID:17029595
IkbkbRat(S)-colchicine affects response to substanceISOIkbkb (Mus musculus)6480464IKBKB protein affects the susceptibility to ColchicineCTDPMID:20159942
IkbkbRat(S)-colchicine multiple interactionsISOIKBKB (Homo sapiens)6480464Colchicine results in decreased localization of [IKBKB protein binds to NFKBIA protein]CTDPMID:17029595
IkbkbRat(S)-naringenin increases expressionISOIkbkb (Mus musculus)6480464naringenin results in increased expression of IKBKB mRNACTDPMID:28395574
IkbkbRat1'-acetoxychavicol acetate multiple interactionsISOIKBKB (Homo sapiens)64804641'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased activity of IKBKB protein] and 1'-acetoxychavicol acetate inhibits the reaction [TNF protein results in increased expression of IKBKB protein]CTDPMID:15905586
IkbkbRat1,2-dimethylhydrazine increases expressionISOIkbkb (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of IKBKB mRNACTDPMID:22206623
IkbkbRat1,2-dimethylhydrazine multiple interactionsISOIkbkb (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of IKBKB mRNA]CTDPMID:22206623
IkbkbRat1,2-naphthoquinone multiple interactionsISOIkbkb (Mus musculus)64804641 more ...CTDPMID:21139339
IkbkbRat1,4-dithiothreitol multiple interactionsISOIKBKB (Homo sapiens)6480464Dithiothreitol inhibits the reaction [3 more ...CTDPMID:20584749
IkbkbRat1,4-dithiothreitol multiple interactionsISOIkbkb (Mus musculus)6480464Dithiothreitol inhibits the reaction [Melitten binds to and results in decreased activity of IKBKB protein] and Dithiothreitol inhibits the reaction [Melitten inhibits the reaction [Nitroprusside results in increased activity of IKBKB protein]]CTDPMID:17067557
IkbkbRat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionEXP 6480464Citalopram results in increased expression of IKBKB mRNACTDPMID:28467792
IkbkbRat15-oxo-ETE multiple interactionsISOIKBKB (Homo sapiens)6480464[15-keto-5 more ...CTDPMID:25450232
IkbkbRat15-oxo-ETE decreases activityISOIKBKB (Homo sapiens)648046415-keto-5 more ...CTDPMID:25450232
IkbkbRat17beta-estradiol multiple interactionsISOIKBKB (Homo sapiens)6480464Estradiol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of IKBKB protein]CTDPMID:26220752

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Biological Process
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IkbkbRatautophagy acts_upstream_of_or_withinISOIkbkb (Mus musculus)1624291 PMID:25891078RGDPMID:25891078
IkbkbRatB cell homeostasis acts_upstream_of_or_withinISOIkbkb (Mus musculus)1624291MGI:2678815 PMID:12235208RGDPMID:12235208
IkbkbRatcanonical NF-kappaB signal transduction involved_inISOIKBKB (Homo sapiens)1624291 PMID:15383541 more ...RGDPMID:15383541 more ...
IkbkbRatcanonical NF-kappaB signal transduction involved_inISOIkbkb (Mus musculus)1624291MGI:1857761 PMID:10229185 and PMID:20434986RGDPMID:10229185 and PMID:20434986
IkbkbRatcellular response to tumor necrosis factor involved_inISSUniProtKB:O149201600115GO_REF:0000024UniProtGO_REF:0000024
IkbkbRatcellular response to tumor necrosis factor involved_inISOIKBKB (Homo sapiens)1624291 PMID:23091055RGDPMID:23091055
IkbkbRatintegrin-mediated signaling pathway acts_upstream_of_or_withinISOIkbkb (Mus musculus)1624291 PMID:36812915RGDPMID:36812915
IkbkbRatintegrin-mediated signaling pathway involved_inISOIkbkb (Mus musculus)1624291 PMID:36812915RGDPMID:36812915
IkbkbRatinterleukin-1-mediated signaling pathway involved_inISOIKBKB (Homo sapiens)1624291 PMID:25816133RGDPMID:25816133
IkbkbRatnegative regulation of autophagy acts_upstream_of_or_withinISOIkbkb (Mus musculus)1624291 PMID:36812915RGDPMID:36812915
IkbkbRatnegative regulation of bicellular tight junction assembly involved_inISOIKBKB (Homo sapiens)1624291 PMID:25816133RGDPMID:25816133
IkbkbRatnegative regulation of canonical NF-kappaB signal transduction acts_upstream_of_or_withinISOIkbkb (Mus musculus)1624291 PMID:7963540RGDPMID:7963540
IkbkbRatnegative regulation of cytokine production involved in inflammatory response involved_inISOIKBKB (Homo sapiens)1624291 PMID:16968406RGDPMID:16968406
IkbkbRatneuron projection development  IMP 7495774 RGD 
IkbkbRatpeptidyl-serine phosphorylation involved_inISOIkbkb (Mus musculus)1624291 PMID:25326420RGDPMID:25326420
IkbkbRatpeptidyl-serine phosphorylation involved_inISOIKBKB (Homo sapiens)1624291 PMID:21399639 and PMID:25326418RGDPMID:21399639 and PMID:25326418
IkbkbRatpositive regulation of canonical NF-kappaB signal transduction involved_inISOIKBKB (Homo sapiens)1624291 PMID:12656673 more ...RGDPMID:12656673 more ...
IkbkbRatpositive regulation of canonical NF-kappaB signal transduction involved_inIBAFB:FBgn0024222 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
IkbkbRatpositive regulation of cation channel activity acts_upstream_of_or_withinISOIkbkb (Mus musculus)1624291MGI:1933754 PMID:18981174RGDPMID:18981174
IkbkbRatpositive regulation of cell population proliferation  IMP 7495757 RGD 
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Cellular Component
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IkbkbRatCD40 receptor complex part_ofISOIkbkb (Mus musculus)1624291 PMID:20614026RGDPMID:20614026
IkbkbRatcytoplasm is_active_inISOIKBKB (Homo sapiens)1624291 PMID:9804806RGDPMID:9804806
IkbkbRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
IkbkbRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
IkbkbRatcytoplasm is_active_inIBAFB:FBgn0024222 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
IkbkbRatcytoplasmic side of plasma membrane located_inISOIkbkb (Mus musculus)1624291 PMID:20614026RGDPMID:20614026
IkbkbRatcytosol located_inISOIKBKB (Homo sapiens) and UniProtKB:O14920-11624291 RGDGO_REF:0000052
IkbkbRatIkappaB kinase complex part_ofISOIKBKB (Homo sapiens)1624291 PMID:20434986RGDPMID:20434986
IkbkbRatIkappaB kinase complex  IDA 2298661 RGD 
IkbkbRatIkappaB kinase complex part_ofISOIkbkb (Mus musculus)1624291 PMID:10229185 and PMID:20434986RGDPMID:10229185 and PMID:20434986
IkbkbRatIkappaB kinase complex part_ofIBAMGI:1338071 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
IkbkbRatIkappaB kinase complex part_ofIEAARBA:ARBA000450441600115GO_REF:0000117UniProtGO_REF:0000117
IkbkbRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
IkbkbRatmembrane raft located_inIEAUniProtKB-SubCell:SL-03701600115GO_REF:0000044UniProtGO_REF:0000044
IkbkbRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
IkbkbRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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IkbkbRatATP binding  IDA 1626124 RGD 
IkbkbRatATP binding enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
IkbkbRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
IkbkbRatidentical protein binding enablesISOIKBKB (Homo sapiens)1624291UniProtKB:O14920 more ...RGDPMID:16319058 more ...
IkbkbRatIkappaB kinase activity contributes_toIDA 13801014 RGD 
IkbkbRatIkappaB kinase activity enablesISOIkbkb (Mus musculus)1624291MGI:1857761 PMID:10229185 more ...RGDPMID:10229185 more ...
IkbkbRatIkappaB kinase activity enablesIEARHEA:190731600115GO_REF:0000116RHEAGO_REF:0000116
IkbkbRatIkappaB kinase activity contributes_toIBAPANTHER:PTN000540281 and Ikbkb (Rattus norvegicus)1600115GO_REF:0000033GO_CentralGO_REF:0000033
IkbkbRatIkappaB kinase activity enablesIEAInterPro:IPR0220071600115GO_REF:0000002InterProGO_REF:0000002
IkbkbRatIkappaB kinase activity enablesIEAEC:2.7.11.101600115GO_REF:0000003UniProtGO_REF:0000003
IkbkbRatIkappaB kinase activity enablesISOIKBKB (Homo sapiens)1624291 PMID:9346484RGDPMID:9346484
IkbkbRatkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
IkbkbRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
IkbkbRatprotein binding  IPITrappc9 (Rattus norvegicus)10045953 RGD 
IkbkbRatprotein binding enablesISOIKBKB (Homo sapiens)1624291UniProtKB:O14965 more ...RGDPMID:10521409 more ...
IkbkbRatprotein binding enablesISOIkbkb (Mus musculus)1624291PR:Q60680 more ...RGDPMID:15102471 more ...
IkbkbRatprotein binding enablesISOIKBKB (Homo sapiens) and UniProtKB:O14920-31624291UniProtKB:Q8WXH2 and PMID:32814053RGDPMID:32814053
IkbkbRatprotein binding enablesIPIUniProtKB:O703778553272PMID:18692471IntAct 
IkbkbRatprotein heterodimerization activity enablesISOIKBKB (Homo sapiens)1624291 PMID:23091055RGDPMID:23091055
IkbkbRatprotein homodimerization activity enablesISSUniProtKB:O149201600115GO_REF:0000024UniProtGO_REF:0000024
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RGD Manual Annotations


  

Imported Annotations - SMPDB

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IkbkbRatadenosine signaling pathway  ISOIKBKB (Homo sapiens)10402751 SMPDBSMP:00320
IkbkbRatadenosine signaling pathway  ISOIKBKB (Homo sapiens)10402751 SMPDBSMP:00321

Imported Annotations - KEGG (archival)

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IkbkbRatacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221
IkbkbRatapoptotic cell death pathway  IEA 6907045 KEGGrno:04210
IkbkbRatB cell receptor signaling pathway  IEA 6907045 KEGGrno:04662
IkbkbRatceramide signaling pathway  IEA 6907045 KEGGrno:05212
IkbkbRatChagas disease pathway  IEA 6907045 KEGGrno:05142
IkbkbRatchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
IkbkbRatchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
IkbkbRathepatitis C pathway  IEA 6907045 KEGGrno:05160
IkbkbRatinfluenza A pathway  IEA 6907045 KEGGrno:05164
IkbkbRatinsulin signaling pathway   IEA 6907045 KEGGrno:04910
IkbkbRatmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
IkbkbRatneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722
IkbkbRatNOD-like receptor signaling pathway  IEA 6907045 KEGGrno:04621
IkbkbRatpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
IkbkbRatprostate cancer pathway   IEA 6907045 KEGGrno:05215
IkbkbRatRetinoic acid-inducible gene (RIG) I-like receptor signaling pathway  IEA 6907045 KEGGrno:04622
IkbkbRatsmall cell lung carcinoma pathway  IEA 6907045 KEGGrno:05222
IkbkbRatT cell receptor signaling pathway  IEA 6907045 KEGGrno:04660
IkbkbRatToll-like receptor signaling pathway   IEA 6907045 KEGGrno:04620
IkbkbRattoxoplasmosis pathway  IEA 6907045 KEGGrno:05145
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Reference Title
Reference Citation
1. Inflammatory related gene IKKα, IKKβ, IKKγ cooperates to determine liver cancer stem cells progression by altering telomere via heterochromatin protein 1-HOTAIR axis. An J, etal., Oncotarget. 2016 Aug 2;7(31):50131-50149. doi: 10.18632/oncotarget.10321.
2. Activation of the IkappaB kinase complex is sufficient for neuronal differentiation of PC12 cells. Azoitei N, etal., J Neurochem. 2005 Jun;93(6):1487-501.
3. Constitutive IKK2 activation in acinar cells is sufficient to induce pancreatitis in vivo. Baumann B, etal., J Clin Invest. 2007 Jun;117(6):1502-13. Epub 2007 May 24.
4. Effects of TCDD upon IkappaB and IKK subunits localized in microsomes by proteomics. Bruno ME, etal., Arch Biochem Biophys. 2002 Oct 15;406(2):153-64.
5. IKKbeta-dependent NF-kappaB pathway controls vascular inflammation and intimal hyperplasia. Bu DX, etal., FASEB J. 2005 Aug;19(10):1293-5. Epub 2005 Jun 6.
6. Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Cai D, etal., Nat Med. 2005 Feb;11(2):183-90. Epub 2005 Jan 30.
7. The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression. Chang NS J Biol Chem 2002 Mar 22;277(12):10323-31.
8. Ischemic preconditioning attenuates renal ischemia-reperfusion injury by inhibiting activation of IKKbeta and inflammatory response. Chen X, etal., Am J Nephrol. 2009;30(3):287-94. doi: 10.1159/000225928. Epub 2009 Jun 16.
9. 20-hydroxy-5,8,11,14-eicosatetraenoic acid mediates endothelial dysfunction via IkappaB kinase-dependent endothelial nitric-oxide synthase uncoupling. Cheng J, etal., J Pharmacol Exp Ther. 2010 Jan;332(1):57-65. doi: 10.1124/jpet.109.159863. Epub 2009 Oct 19.
10. An NF-κB pathway-mediated positive feedback loop amplifies Ras activity to pathological levels in mice. Daniluk J, etal., J Clin Invest. 2012 Apr;122(4):1519-28. doi: 10.1172/JCI59743. Epub 2012 Mar 12.
11. Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis. Dyckman AJ, etal., Bioorg Med Chem Lett. 2011 Jan 1;21(1):383-6. doi: 10.1016/j.bmcl.2010.10.133. Epub 2010 Oct 31.
12. Glutamine inhibits over-expression of pro-inflammatory genes and down-regulates the nuclear factor kappaB pathway in an experimental model of colitis in the rat. Fillmann H, etal., Toxicology. 2007 Jul 17;236(3):217-26. Epub 2007 Apr 27.
13. NEMO oligomerization in the dynamic assembly of the IkappaB kinase core complex. Fontan E, etal., FEBS J. 2007 May;274(10):2540-51. Epub 2007 Apr 10.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Periodic, partial inhibition of IkappaB Kinase beta-mediated signaling yields therapeutic benefit in preclinical models of rheumatoid arthritis. Gillooly KM, etal., J Pharmacol Exp Ther. 2009 Nov;331(2):349-60. doi: 10.1124/jpet.109.156018. Epub 2009 Aug 3.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Heat treatment improves glucose tolerance and prevents skeletal muscle insulin resistance in rats fed a high-fat diet. Gupte AA, etal., Diabetes. 2009 Mar;58(3):567-78. doi: 10.2337/db08-1070. Epub 2008 Dec 10.
18. Lipoic acid increases heat shock protein expression and inhibits stress kinase activation to improve insulin signaling in skeletal muscle from high-fat-fed rats. Gupte AA, etal., J Appl Physiol (1985). 2009 Apr;106(4):1425-34. doi: 10.1152/japplphysiol.91210.2008. Epub 2009 Jan 29.
19. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
20. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism. Hayes JD and Dinkova-Kostova AT, Trends Biochem Sci. 2014 Apr;39(4):199-218. doi: 10.1016/j.tibs.2014.02.002. Epub 2014 Mar 16.
1 to 20 of 62 rows
PMID:9819420   PMID:12235208   PMID:12492477   PMID:12857501   PMID:14743216   PMID:15084260   PMID:15383541   PMID:15684432   PMID:15790681   PMID:16079148   PMID:16079150   PMID:16319058  
PMID:17009244   PMID:17318081   PMID:17954568   PMID:18981174   PMID:19088076   PMID:19362079   PMID:19386987   PMID:19569009   PMID:20434986   PMID:20614026   PMID:20646420   PMID:20930169  
PMID:21399639   PMID:21423167   PMID:22982470   PMID:23016877   PMID:23091055   PMID:23418625   PMID:23453807   PMID:23563696   PMID:23613522   PMID:23776175   PMID:23776406   PMID:24135021  
PMID:24825147   PMID:25636800   PMID:25816133   PMID:26212789   PMID:26514267   PMID:28673900   PMID:29785049   PMID:30337470   PMID:30988283   PMID:31297885   PMID:31549412   PMID:34073390  
PMID:35132967  



Ikbkb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81676,021,968 - 76,075,717 (+)NCBIGRCr8
mRatBN7.21669,319,487 - 69,373,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1674,593,277 - 74,646,961 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01678,025,765 - 78,078,546 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01673,274,913 - 73,327,717 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01674,177,233 - 74,230,809 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1674,177,215 - 74,230,815 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01673,809,854 - 73,863,636 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41673,804,730 - 73,858,510 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11673,805,346 - 73,858,348 (+)NCBI
Celera1667,214,025 - 67,266,348 (+)NCBICelera
Cytogenetic Map16q12.5NCBI
IKBKB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38842,271,302 - 42,332,460 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl842,271,302 - 42,332,460 (+)EnsemblGRCh38hg38GRCh38
GRCh37842,128,820 - 42,189,978 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,247,986 - 42,309,122 (+)NCBINCBI36Build 36hg18NCBI36
Build 34842,247,985 - 42,309,122NCBI
Celera841,077,798 - 41,138,835 (+)NCBICelera
Cytogenetic Map8p11.21NCBI
HuRef840,656,604 - 40,717,697 (+)NCBIHuRef
CHM1_1842,177,451 - 42,238,764 (+)NCBICHM1_1
T2T-CHM13v2.0842,545,654 - 42,606,501 (+)NCBIT2T-CHM13v2.0
Ikbkb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39823,149,228 - 23,196,605 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl823,149,228 - 23,196,605 (-)EnsemblGRCm39 Ensembl
GRCm38822,659,205 - 22,706,589 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl822,659,212 - 22,706,589 (-)EnsemblGRCm38mm10GRCm38
MGSCv37823,769,677 - 23,817,055 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36824,125,308 - 24,172,108 (-)NCBIMGSCv36mm8
Celera824,149,472 - 24,196,863 (-)NCBICelera
Cytogenetic Map8A2NCBI
cM Map811.42NCBI
Ikbkb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955536612,774 - 658,647 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955536611,965 - 658,647 (-)NCBIChiLan1.0ChiLan1.0
IKBKB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2760,723,875 - 60,784,734 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1836,441,096 - 36,501,335 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0841,515,613 - 41,576,229 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1838,960,594 - 39,020,971 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl838,960,594 - 39,020,971 (+)Ensemblpanpan1.1panPan2
IKBKB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11623,359,551 - 23,419,114 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1623,359,813 - 23,419,075 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1623,864,109 - 23,923,669 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01625,108,158 - 25,167,347 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1625,108,158 - 25,167,336 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11623,479,268 - 23,538,442 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01624,042,615 - 24,101,962 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01624,093,332 - 24,152,694 (-)NCBIUU_Cfam_GSD_1.0
Ikbkb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494346,401,726 - 46,450,359 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936785356,168 - 406,773 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936785358,128 - 406,751 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IKBKB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1711,289,690 - 11,348,549 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11711,289,607 - 11,348,557 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21713,063,170 - 13,101,270 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IKBKB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1840,267,532 - 40,325,282 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl840,268,079 - 40,326,381 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660521,461,878 - 1,520,432 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ikbkb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624780923,744 - 970,519 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624780922,524 - 978,687 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ikbkb
446 total Variants

Predicted Target Of
Summary Value
Count of predictions:468
Count of miRNA genes:251
Interacting mature miRNAs:306
Transcripts:ENSRNOT00000025851
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 14 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631525Pia14Pristane induced arthritis QTL 144.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)165571108783402471Rat
1298527Arunc2Aerobic running capacity QTL 22.9exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)166853271675029966Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
7411648Foco22Food consumption QTL 22150.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)165272646484729064Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat

1 to 10 of 14 rows
RH131248  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,372,599 - 69,372,802 (+)MAPPERmRatBN7.2
Rnor_6.01674,230,158 - 74,230,360NCBIRnor6.0
Rnor_5.01673,862,985 - 73,863,187UniSTSRnor5.0
RGSC_v3.41673,857,859 - 73,858,061UniSTSRGSC3.4
Celera1667,265,697 - 67,265,899UniSTS
RH 3.4 Map16691.7UniSTS
Cytogenetic Map16q12.5UniSTS
RH138696  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,370,092 - 69,370,227 (+)MAPPERmRatBN7.2
Rnor_6.01674,227,651 - 74,227,785NCBIRnor6.0
Rnor_5.01673,860,478 - 73,860,612UniSTSRnor5.0
RGSC_v3.41673,855,352 - 73,855,486UniSTSRGSC3.4
Celera1667,263,190 - 67,263,324UniSTS
RH 3.4 Map16663.21UniSTS
Cytogenetic Map16q12.5UniSTS
RH139961  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,372,999 - 69,373,186 (+)MAPPERmRatBN7.2
Rnor_6.01674,230,558 - 74,230,744NCBIRnor6.0
Rnor_5.01673,863,385 - 73,863,571UniSTSRnor5.0
RGSC_v3.41673,858,259 - 73,858,445UniSTSRGSC3.4
Celera1667,266,097 - 67,266,283UniSTS
RH 3.4 Map16691.4UniSTS
Cytogenetic Map16q12.5UniSTS
BF390838  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21669,330,561 - 69,330,719 (+)MAPPERmRatBN7.2
Rnor_6.01674,188,233 - 74,188,390NCBIRnor6.0
Rnor_5.01673,820,854 - 73,821,011UniSTSRnor5.0
RGSC_v3.41673,815,730 - 73,815,887UniSTSRGSC3.4
Celera1667,225,025 - 67,225,182UniSTS
RH 3.4 Map16665.92UniSTS
Cytogenetic Map16q12.5UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000025851   ⟹   ENSRNOP00000025851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)Ensembl
Rnor_6.0 Ensembl1674,177,215 - 74,230,815 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097362   ⟹   ENSRNOP00000077348
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1669,319,554 - 69,373,250 (+)Ensembl
RefSeq Acc Id: NM_053355   ⟹   NP_445807
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,022,031 - 76,075,717 (+)NCBI
mRatBN7.21669,319,555 - 69,373,251 (+)NCBI
Rnor_6.01674,177,233 - 74,230,809 (+)NCBI
Rnor_5.01673,809,854 - 73,863,636 (+)NCBI
RGSC_v3.41673,804,730 - 73,858,510 (+)RGD
Celera1667,214,025 - 67,266,348 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094867   ⟹   XP_038950795
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,021,968 - 76,064,837 (+)NCBI
mRatBN7.21669,319,487 - 69,362,366 (+)NCBI
RefSeq Acc Id: XM_063275786   ⟹   XP_063131856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,021,968 - 76,075,717 (+)NCBI
RefSeq Acc Id: XM_063275787   ⟹   XP_063131857
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81676,021,968 - 76,064,838 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_445807 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950795 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131856 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131857 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF21978 (Get FASTA)   NCBI Sequence Viewer  
  EDM09011 (Get FASTA)   NCBI Sequence Viewer  
  EDM09012 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025851
  ENSRNOP00000112638
GenBank Protein Q9QY78 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_445807   ⟸   NM_053355
- UniProtKB: Q9QY78 (UniProtKB/Swiss-Prot),   G3V8H5 (UniProtKB/TrEMBL),   A6IW61 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025851   ⟸   ENSRNOT00000025851
RefSeq Acc Id: XP_038950795   ⟸   XM_039094867
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000077348   ⟸   ENSRNOT00000097362
RefSeq Acc Id: XP_063131856   ⟸   XM_063275786
- Peptide Label: isoform X1
- UniProtKB: Q9QY78 (UniProtKB/Swiss-Prot)
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-Q9QY78-F1-model_v2 AlphaFold Q9QY78 1-757 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700184
Promoter ID:EPDNEW_R10708
Type:initiation region
Name:Ikbkb_1
Description:inhibitor of nuclear factor kappa B kinase subunit beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01674,177,222 - 74,177,282EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-10881 BioCyc
Ensembl Genes ENSRNOG00000019073 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000025851 ENTREZGENE
  ENSRNOT00000154195 ENTREZGENE
Gene3D-CATH 1.20.1270.250 UniProtKB/Swiss-Prot
  6.10.250.2110 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro IKBKB_SDD UniProtKB/Swiss-Prot
  IKBKB_SDD_sf UniProtKB/Swiss-Prot
  IKK UniProtKB/Swiss-Prot
  IKKbetaNEMObind UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:84351 UniProtKB/Swiss-Prot
NCBI Gene 84351 ENTREZGENE
PANTHER IKB KINASE UniProtKB/Swiss-Prot
  INHIBITOR OF NUCLEAR FACTOR KAPPA-B KINASE SUBUNIT BETA UniProtKB/Swiss-Prot
Pfam IKBKB_SDD UniProtKB/Swiss-Prot
  IKKbetaNEMObind UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Ikbkb PhenoGen
PROSITE PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019073 RatGTEx
SMART IKKbetaNEMObind UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A0A8I5ZJG2_RAT UniProtKB/TrEMBL
  A6IW60_RAT UniProtKB/TrEMBL
  A6IW61 ENTREZGENE, UniProtKB/TrEMBL
  G3V8H5 ENTREZGENE, UniProtKB/TrEMBL
  IKKB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-02-01 Ikbkb  inhibitor of nuclear factor kappa B kinase subunit beta  Ikbkb  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-02-26 Ikbkb  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta  Ikbkb  inhibitor of kappaB kinase beta  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ikbkb  inhibitor of kappaB kinase beta    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta  Name updated 1299863 APPROVED
2002-08-07 Ikbkb  inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in megakaryocytes 633167
gene_expression expressed in rat liver and spleen cells 70526
gene_function cytosolic fragment interacts physically with p53 and prevents the nuclear translocation of p53  
gene_physical_interaction cytosolic fragment interacts physically with p53 and prevents the nuclear translocation of p53 70526
gene_process regulates growth 70526
gene_process forms a complex with p53 and the dissociation of this complex results in growth suppression by Tgf-b1, apoptosis, stress, hypoxia, DNA damage and UV radiation  
gene_regulation forms a complex with p53 and the dissociation of this complex results in growth suppression by Tgf-b1, apoptosis, stress, hypoxia, DNA damage and UV radiation 70526