Enpep (glutamyl aminopeptidase) - Rat Genome Database

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Gene: Enpep (glutamyl aminopeptidase) Rattus norvegicus
Analyze
Symbol: Enpep
Name: glutamyl aminopeptidase
RGD ID: 621228
Description: Enables aminopeptidase activity and peptide binding activity. Involved in peptide catabolic process and protein processing. Located in brush border membrane. Orthologous to human ENPEP (glutamyl aminopeptidase); PARTICIPATES IN angiotensin III signaling pathway; renin-angiotensin cascade pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: aminopeptidase A; AP-A; EAP; glutamyl aminopeptidase-like; LOC100910501
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,456,258 - 220,526,218 (-)NCBIGRCr8
mRatBN7.22217,781,985 - 217,851,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,456,243 - 225,526,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,355,888 - 223,425,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,213,588 - 218,283,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02233,667,253 - 233,743,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,991,592 - 253,066,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,731,079 - 226,732,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,717,758 - 226,718,749 (-)NCBI
Celera2210,077,457 - 210,147,068 (-)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
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Reference
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Original Reference(s)
EnpepRatautistic disorder  ISOENPEP (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVar 
Object Symbol
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Original Reference(s)
EnpepRatDiabetic Nephropathies  ISOENPEP (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28468961
EnpepRatExperimental Liver Cirrhosis  ISOENPEP (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25380136

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Original Reference(s)
EnpepRat(1->4)-beta-D-glucan multiple interactionsISOEnpep (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ENPEP mRNACTDPMID:36331819
EnpepRat1,2,4-trimethylbenzene increases expressionEXP 6480464pseudocumene results in increased expression of ENPEP proteinCTDPMID:17337753
EnpepRat1,2-dimethylhydrazine decreases expressionISOEnpep (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of ENPEP mRNACTDPMID:22206623
EnpepRat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of ENPEP mRNACTDPMID:25380136
EnpepRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of ENPEP mRNACTDPMID:32145629
EnpepRat17beta-estradiol decreases expressionISOENPEP (Homo sapiens)6480464Estradiol results in decreased expression of ENPEP mRNACTDPMID:31614463
EnpepRat17beta-estradiol decreases expressionISOEnpep (Mus musculus)6480464Estradiol results in decreased expression of ENPEP mRNACTDPMID:39298647
EnpepRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ENPEP mRNACTDPMID:20959002
EnpepRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOEnpep (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ENPEP mRNACTDPMID:26377647
EnpepRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOEnpep (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of ENPEP mRNACTDPMID:16214954 more ...
EnpepRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOEnpep (Mus musculus)6480464AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENPEP mRNA]CTDPMID:16214954
EnpepRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of ENPEP mRNACTDPMID:21346803
EnpepRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of ENPEP mRNACTDPMID:21346803
EnpepRat2-naphthylamine increases metabolic processingISOENPEP (Homo sapiens)6480464ENPEP protein results in increased metabolism of 2-Naphthylamine analogCTDPMID:11732752
EnpepRat2-naphthylamine increases metabolic processingEXP 6480464ENPEP protein results in increased metabolism of 2-Naphthylamine analogCTDPMID:11732752
EnpepRat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:20959002
EnpepRat3-methylcholanthrene decreases expressionISOEnpep (Mus musculus)6480464Methylcholanthrene results in decreased expression of ENPEP mRNACTDPMID:20713471
EnpepRat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of ENPEP mRNACTDPMID:19162173
EnpepRat4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of ENPEP mRNACTDPMID:25380136 and PMID:30723492
EnpepRat4,4'-diaminodiphenylmethane affects expressionISOEnpep (Mus musculus)64804644 and 4'-diaminodiphenylmethane affects the expression of ENPEP mRNACTDPMID:18648102

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Biological Process
1 to 20 of 22 rows

  
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Original Reference(s)
EnpepRatangiogenesis acts_upstream_of_or_withinISOEnpep (Mus musculus)1624291MGI:2182774 PMID:14998491RGDPMID:14998491
EnpepRatangiogenesis acts_upstream_of_or_withinIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatangiotensin maturation involved_inISOEnpep (Mus musculus)1624291MGI:2182774 PMID:16889841 and PMID:19228697RGDPMID:16889841 and PMID:19228697
EnpepRatangiotensin maturation involved_inIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatcell migration acts_upstream_of_or_withinISOENPEP (Homo sapiens)1624291 PMID:14998491RGDPMID:14998491
EnpepRatcell migration acts_upstream_of_or_withinIEAUniProtKB:Q07075 and ensembl:ENSP000002651621600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatcell migration involved_inISSUniProtKB:Q070751600115GO_REF:0000024UniProtGO_REF:0000024
EnpepRatcell population proliferation involved_inISSUniProtKB:Q070751600115GO_REF:0000024UniProtGO_REF:0000024
EnpepRatcell population proliferation acts_upstream_of_or_withinIEAUniProtKB:Q07075 and ensembl:ENSP000002651621600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatcell population proliferation acts_upstream_of_or_withinISOENPEP (Homo sapiens)1624291 PMID:14998491RGDPMID:14998491
EnpepRatglomerulus development involved_inIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatglomerulus development involved_inISOEnpep (Mus musculus)1624291 PMID:16286663RGDPMID:16286663
EnpepRatpeptide catabolic process  IDA 1626500 RGD 
EnpepRatpeptide catabolic process involved_inIBAPANTHER:PTN000164250 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
EnpepRatprotein processing  IDA 1581649 RGD 
EnpepRatproteolysis involved_inIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
EnpepRatproteolysis involved_inIBAFB:FBgn0285963 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
EnpepRatproteolysis involved_inIEAInterPro:IPR0019301600115GO_REF:0000002InterProGO_REF:0000002
EnpepRatregulation of blood pressure involved_inIBAMGI:106645 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
EnpepRatregulation of systemic arterial blood pressure by renin-angiotensin involved_inISOENPEP (Homo sapiens)1624291 PMID:19608358RGDPMID:19608358
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Cellular Component
1 to 20 of 21 rows

  
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Original Reference(s)
EnpepRatapical part of cell located_inIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatapical part of cell located_inISOEnpep (Mus musculus)1624291 PMID:16286663RGDPMID:16286663
EnpepRatapical plasma membrane located_inIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatapical plasma membrane located_inISOEnpep (Mus musculus)1624291 PMID:16286663RGDPMID:16286663
EnpepRatbrush border located_inIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatbrush border located_inISOEnpep (Mus musculus)1624291 PMID:16286663RGDPMID:16286663
EnpepRatbrush border membrane  IDA 1626500 RGD 
EnpepRatcytoplasm is_active_inIBAFB:FBgn0039640 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
EnpepRatcytoplasmic vesicle located_inIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatcytoplasmic vesicle located_inISOEnpep (Mus musculus)1624291 PMID:16286663RGDPMID:16286663
EnpepRatexternal side of plasma membrane is_active_inISOEnpep (Mus musculus)1624291 PMID:16889841RGDPMID:16889841
EnpepRatexternal side of plasma membrane located_inISOEnpep (Mus musculus)1624291 PMID:7795661RGDPMID:7795661
EnpepRatexternal side of plasma membrane located_inIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatextracellular space is_active_inIBAPANTHER:PTN000164250 and UniProtKB:P151441600115GO_REF:0000033GO_CentralGO_REF:0000033
EnpepRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
EnpepRatplasma membrane located_inISOENPEP (Homo sapiens)1624291 PMID:10692253RGDPMID:10692253
EnpepRatplasma membrane is_active_inIBAMGI:106645 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
EnpepRatplasma membrane located_inISSUniProtKB:Q070751600115GO_REF:0000024UniProtGO_REF:0000024
EnpepRatplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
EnpepRatplasma membrane located_inIEAUniProtKB:Q07075 and ensembl:ENSP000002651621600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
EnpepRataminopeptidase activity  IDA 631866 RGD 
EnpepRataminopeptidase activity enablesIEAUniProtKB:Q07075 and ensembl:ENSP000002651621600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRataminopeptidase activity enablesISOENPEP (Homo sapiens)1624291 PMID:10692253 and PMID:8244382RGDPMID:10692253 and PMID:8244382
EnpepRataminopeptidase activity enablesIEAUniProtKB-KW:KW-00311600115GO_REF:0000043UniProtGO_REF:0000043
EnpepRataminopeptidase activity  IDA 1581649 RGD 
EnpepRatglutamyl aminopeptidase activity enablesIEAEC:3.4.11.71600115GO_REF:0000003UniProtGO_REF:0000003
EnpepRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
EnpepRatmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
EnpepRatmetalloaminopeptidase activity enablesISSUniProtKB:Q070751600115GO_REF:0000024UniProtGO_REF:0000024
EnpepRatmetalloaminopeptidase activity enablesIBACGD:CAL0000186164 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
EnpepRatmetalloaminopeptidase activity enablesISOENPEP (Homo sapiens)1624291 PMID:23888046 and PMID:8346219RGDPMID:23888046 and PMID:8346219
EnpepRatmetalloaminopeptidase activity enablesIEAUniProtKB:Q07075 and ensembl:ENSP000002651621600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatmetallopeptidase activity enablesIEAUniProtKB-KW:KW-04821600115GO_REF:0000043UniProtGO_REF:0000043
EnpepRatmetallopeptidase activity enablesIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatmetallopeptidase activity enablesIEAInterPro:IPR0147821600115GO_REF:0000002InterProGO_REF:0000002
EnpepRatmetallopeptidase activity enablesISOEnpep (Mus musculus)1624291MGI:2182774 PMID:16889841 and PMID:19228697RGDPMID:16889841 and PMID:19228697
EnpepRatpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
EnpepRatpeptidase activity enablesIEAARBA:ARBA000274081600115GO_REF:0000117UniProtGO_REF:0000117
EnpepRatpeptidase activity enablesIEAUniProtKB:P16406 and ensembl:ENSMUSP000000296581600115GO_REF:0000107EnsemblGO_REF:0000107
EnpepRatpeptidase activity enablesISOEnpep (Mus musculus)1624291 PMID:14998491RGDPMID:14998491
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RGD Manual Annotations


  
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Original Reference(s)
EnpepRatangiotensin III signaling pathway  IDA 1581649 RGD 
EnpepRatrenin-angiotensin cascade pathway   IDA 1581649 RGD 
EnpepRatrenin-angiotensin cascade pathway   ISOENPEP (Homo sapiens)1581742 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
EnpepRatrenin-angiotensin cascade pathway   IEA 6907045 KEGGrno:04614

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#
Reference Title
Reference Citation
1. Renin-angiotensin system-regulating aminopeptidase activities are modified in the pineal gland of rats with breast cancer induced by N-methyl-nitrosourea. Carrera MP, etal., Cancer Invest. 2006 Mar;24(2):149-53.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Targeting the renin-angiotensin system: what's new? Leckie BJ Curr Med Chem Cardiovasc Hematol Agents. 2005 Jan;3(1):23-32.
5. Molecular cloning and expression of aminopeptidase A isoforms from rat hippocampus. Lee HJ, etal., Biochim Biophys Acta 2000 Sep 7;1493(1-2):273-8.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. The luminal membrane of rat thick limb expresses AT1 receptor and aminopeptidase activities. Poumarat JS, etal., Kidney Int. 2002 Aug;62(2):434-45.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Rat kidney glutamyl aminopeptidase (aminopeptidase A): molecular identity and cellular localization. Song L, etal., Am J Physiol 1994 Oct;267(4 Pt 2):F546-57.
14. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
15. Expression of aminopeptidase A, an angiotensinase, in glomerular mesangial cells. Troyanovskaya M, etal., Hypertension 1996 Mar;27(3 Pt 2):518-22.
1 to 15 of 15 rows
PMID:7795661   PMID:8244382   PMID:8346219   PMID:10692253   PMID:14998491   PMID:15489334   PMID:15682487   PMID:16286663   PMID:16790432   PMID:17519555   PMID:17897319   PMID:19056867  
PMID:19608358   PMID:22206666   PMID:23376485   PMID:23533145   PMID:23888046   PMID:25960007   PMID:33161775  



Enpep
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82220,456,258 - 220,526,218 (-)NCBIGRCr8
mRatBN7.22217,781,985 - 217,851,947 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2225,456,243 - 225,526,211 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02223,355,888 - 223,425,871 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02218,213,588 - 218,283,553 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02233,667,253 - 233,743,866 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02252,991,592 - 253,066,142 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42226,731,079 - 226,732,069 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12226,717,758 - 226,718,749 (-)NCBI
Celera2210,077,457 - 210,147,068 (-)NCBICelera
Cytogenetic Map2q42NCBI
ENPEP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384110,476,155 - 110,565,285 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4110,365,733 - 110,565,285 (+)EnsemblGRCh38hg38GRCh38
GRCh374111,397,311 - 111,486,441 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364111,616,678 - 111,703,942 (+)NCBINCBI36Build 36hg18NCBI36
Build 344111,754,928 - 111,841,027NCBI
Celera4108,691,011 - 108,778,278 (+)NCBICelera
Cytogenetic Map4q25NCBI
HuRef4107,128,917 - 107,216,191 (+)NCBIHuRef
CHM1_14111,373,917 - 111,461,184 (+)NCBICHM1_1
T2T-CHM13v2.04113,778,214 - 113,867,343 (+)NCBIT2T-CHM13v2.0
Enpep
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393129,062,826 - 129,126,398 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3129,062,824 - 129,126,369 (-)EnsemblGRCm39 Ensembl
GRCm383129,269,177 - 129,332,749 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3129,269,175 - 129,332,720 (-)EnsemblGRCm38mm10GRCm38
MGSCv373128,972,095 - 129,035,667 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363129,261,642 - 129,324,742 (-)NCBIMGSCv36mm8
Celera3135,776,158 - 135,839,883 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map357.92NCBI
Enpep
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495545715,863,881 - 15,943,074 (-)NCBIChiLan1.0ChiLan1.0
ENPEP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23108,564,622 - 108,650,616 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14108,857,811 - 108,943,716 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04102,969,397 - 103,056,978 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14113,534,565 - 113,620,654 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4113,532,126 - 113,620,654 (+)Ensemblpanpan1.1panPan2
ENPEP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13230,553,055 - 30,639,790 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3230,553,182 - 30,638,522 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3211,396,688 - 11,483,396 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03230,773,999 - 30,860,935 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3230,774,117 - 30,859,344 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13230,760,121 - 30,846,715 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03230,511,400 - 30,597,700 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0329,256,791 - 9,343,499 (-)NCBIUU_Cfam_GSD_1.0
Enpep
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530110,285,323 - 10,365,581 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365631,585,471 - 1,665,677 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365631,585,450 - 1,665,663 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ENPEP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8111,748,514 - 111,858,510 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18111,765,839 - 111,858,349 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28119,968,866 - 120,060,970 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ENPEP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1758,363,816 - 58,448,231 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl758,364,445 - 58,447,574 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603737,045,128 - 37,128,693 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Enpep
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248384,742,794 - 4,828,724 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248384,742,841 - 4,826,767 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Enpep
400 total Variants

Predicted Target Of
Summary Value
Count of predictions:335
Count of miRNA genes:186
Interacting mature miRNAs:205
Transcripts:ENSRNOT00000074879
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 43 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat

1 to 10 of 43 rows
D2Wox67  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,853,183 - 217,853,423 (+)MAPPERmRatBN7.2
Rnor_6.02233,984,120 - 233,984,359NCBIRnor6.0
Rnor_6.02233,745,103 - 233,745,342NCBIRnor6.0
Rnor_5.02253,067,379 - 253,067,618UniSTSRnor5.0
Rnor_5.02253,306,223 - 253,306,462UniSTSRnor5.0
RGSC_v3.42226,734,175 - 226,734,414UniSTSRGSC3.4
Celera2210,148,305 - 210,148,544UniSTS
Cytogenetic Map2q42UniSTS
RH133895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,782,221 - 217,782,439 (+)MAPPERmRatBN7.2
Rnor_6.02233,667,471 - 233,667,688NCBIRnor6.0
Rnor_5.02252,991,810 - 252,992,027UniSTSRnor5.0
Celera2210,077,694 - 210,077,911UniSTS
RH 3.4 Map21557.4UniSTS
Cytogenetic Map2q42UniSTS
BE111146  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22217,819,206 - 217,819,402 (+)MAPPERmRatBN7.2
Rnor_6.02233,704,485 - 233,704,680NCBIRnor6.0
Rnor_5.02253,028,989 - 253,029,184UniSTSRnor5.0
Celera2210,114,297 - 210,114,492UniSTS
RH 3.4 Map21546.7UniSTS
Cytogenetic Map2q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000087062   ⟹   ENSRNOP00000068728
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)Ensembl
Rnor_6.0 Ensembl2233,667,254 - 233,743,866 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000107896   ⟹   ENSRNOP00000085978
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2217,782,005 - 217,851,947 (-)Ensembl
RefSeq Acc Id: NM_022251   ⟹   NP_071587
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82220,456,258 - 220,526,218 (-)NCBI
mRatBN7.22217,781,985 - 217,851,947 (-)NCBI
Rnor_6.02233,667,253 - 233,743,866 (-)NCBI
Rnor_5.02252,991,592 - 253,066,142 (-)NCBI
RGSC_v3.42226,731,079 - 226,732,069 (-)RGD
Celera2210,077,457 - 210,147,068 (-)RGD
Sequence:
Protein RefSeqs NP_071587 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAF37622 (Get FASTA)   NCBI Sequence Viewer  
  AAF66710 (Get FASTA)   NCBI Sequence Viewer  
  AAH66663 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000068728
GenBank Protein P50123 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071587   ⟸   NM_022251
- UniProtKB: Q9QV24 (UniProtKB/Swiss-Prot),   Q9JLQ9 (UniProtKB/Swiss-Prot),   Q9JLQ7 (UniProtKB/Swiss-Prot),   Q64200 (UniProtKB/Swiss-Prot),   P50123 (UniProtKB/Swiss-Prot),   A0A0G2JTI8 (UniProtKB/TrEMBL),   A6HVN5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068728   ⟸   ENSRNOT00000087062
Ensembl Acc Id: ENSRNOP00000085978   ⟸   ENSRNOT00000107896
Aminopeptidase N-like N-terminal   ERAP1-like C-terminal   Peptidase M1 membrane alanine aminopeptidase

Name Modeler Protein Id AA Range Protein Structure
AF-P50123-F1-model_v2 AlphaFold P50123 1-945 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691746
Promoter ID:EPDNEW_R2271
Type:multiple initiation site
Name:Enpep_1
Description:glutamyl aminopeptidase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02233,743,698 - 233,743,758EPDNEW


1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51247 BioCyc
Ensembl Genes ENSRNOG00000051854 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000087062 ENTREZGENE
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot
  1.25.50.20 UniProtKB/Swiss-Prot
  2.60.40.1730 UniProtKB/Swiss-Prot
  2.60.40.1910 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5623429 IMAGE-MGC_LOAD
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  ERAP1-like_C_dom UniProtKB/Swiss-Prot
  M1_APN-typ UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_aminopeptidases UniProtKB/Swiss-Prot
  Peptidase_M1_dom UniProtKB/Swiss-Prot
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot
KEGG Report rno:64017 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72453 IMAGE-MGC_LOAD
NCBI Gene 64017 ENTREZGENE
PANTHER GLUTAMYL AMINOPEPTIDASE UniProtKB/Swiss-Prot
  PROTEASE M1 ZINC METALLOPROTEASE UniProtKB/Swiss-Prot
Pfam ERAP1_C UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_N UniProtKB/Swiss-Prot
PhenoGen Enpep PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000051854 RatGTEx
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/Swiss-Prot
  SSF63737 UniProtKB/Swiss-Prot
UniProt A0A0G2JTI8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A4U4_RAT UniProtKB/TrEMBL
  A6HVN5 ENTREZGENE, UniProtKB/TrEMBL
  AMPE_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q64200 ENTREZGENE
  Q9JLQ7 ENTREZGENE
  Q9JLQ9 ENTREZGENE
  Q9QV24 ENTREZGENE
UniProt Secondary Q64200 UniProtKB/Swiss-Prot
  Q9JLQ7 UniProtKB/Swiss-Prot
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Enpep  glutamyl aminopeptidase  LOC100910501  glutamyl aminopeptidase-like  Data merged from RGD:6498411 737654 PROVISIONAL
2012-07-05 LOC100910501  glutamyl aminopeptidase-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Enpep  glutamyl aminopeptidase    aminopeptidase A  Name updated 1299863 APPROVED
2002-08-07 Enpep  aminopeptidase A      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in the glomerular mesangial cells 631868
gene_process may play a role in modulating the activity of intrarenal angiotensin II  
gene_process minimizes the contraction due to angiotensin II in stimulated mesangial cells 631868