Txn1 (thioredoxin 1) - Rat Genome Database

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Gene: Txn1 (thioredoxin 1) Rattus norvegicus
Analyze
Symbol: Txn1
Name: thioredoxin 1
RGD ID: 621157
Description: Enables enzyme binding activity. Involved in several processes, including cellular response to hyperoxia; response to dexamethasone; and response to thyroxine. Located in axon; dendrite; and neuronal cell body. Biomarker of glaucoma and steatotic liver disease. Orthologous to human TXN (thioredoxin); PARTICIPATES IN adenine phoshoribosyltransferase deficiency pathway; adenosine monophosphate deaminase deficiency pathway; adenylosuccinate lyase deficiency pathway; INTERACTS WITH (R)-lipoic acid; (R,R,R)-alpha-tocopherol; (S)-nicotine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: thioredoxin; trx; Txn
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8577,507,455 - 77,519,685 (-)NCBIGRCr8
mRatBN7.2572,712,334 - 72,724,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl572,711,933 - 72,724,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,603,651 - 74,615,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0576,425,269 - 76,437,499 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0576,397,400 - 76,409,630 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0575,049,735 - 75,057,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,201,386 - 79,209,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,921,365 - 75,933,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1575,926,428 - 75,938,789 (-)NCBI
Celera571,558,162 - 71,570,393 (-)NCBICelera
RH 3.4 Map5494.0RGD
Cytogenetic Map5q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Term
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Evidence
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Reference
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Original Reference(s)
Txn1RatArterial Occlusive Diseases  ISOTXN (Homo sapiens)1580783 RGD 
Txn1Ratdilated cardiomyopathy  ISOTXN (Homo sapiens)1580782 RGD 
Txn1RatExperimental Diabetes Mellitus  IEP 5133714mRNA:altered expression:myocardium (rat)RGD 
Txn1Ratglaucoma  IEP 2306193protein:decreased expression:retinal ganglion cellRGD 
Txn1Ratintermediate coronary syndrome  ISOTXN (Homo sapiens)1580784 RGD 
Txn1Ratmyocardial infarction  ISOTXN (Homo sapiens)1580785 RGD 
Txn1RatMyocardial Reperfusion Injury  IEP 2306159mRNA:decreased expression:heartRGD 
Txn1Ratmyocarditis  ISOTXN (Homo sapiens)1580782 RGD 
Txn1RatReperfusion Injury  IEP 5685030mRNA:decreased expression:cerebral cortexRGD 
Txn1Ratsteatotic liver disease  IEP 2306156 RGD 
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Original Reference(s)
Txn1Ratfetal akinesia deformation sequence syndrome 1  ISOTXN (Homo sapiens)8554872ClinVar Annotator: match by term: Fetal akinesia deformation sequence 1ClinVarPMID:28492532
1 to 13 of 13 rows
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Original Reference(s)
Txn1RatAcute Lung Injury  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:16298680
Txn1RatBreast Neoplasms  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30396169
Txn1Ratbronchopulmonary dysplasia  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:20812253
Txn1Ratcardiomyopathy  ISOTxn1 (Mus musculus)11554173CTD Direct Evidence: therapeuticCTDPMID:12221060
Txn1RatCongenital Abnormalities  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:31310794
Txn1Ratcontact dermatitis  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Txn1RatDrug-Related Side Effects and Adverse Reactions  ISOTxn1 (Mus musculus)11554173CTD Direct Evidence: therapeuticCTDPMID:11462148
Txn1RatExperimental Neoplasms  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28574600
Txn1Rathydrocephalus  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31310794
Txn1Ratliver disease  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:16996028
Txn1Ratmalignant mesothelioma  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27032653
Txn1RatNeoplasm Invasiveness  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15048980
Txn1RatNeoplasm Metastasis  ISOTXN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30396169
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1 to 20 of 487 rows

  
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Original Reference(s)
Txn1Rat(-)-epigallocatechin 3-gallate increases expressionISOTXN (Homo sapiens)6480464epigallocatechin gallate results in increased expression of TXN mRNACTDPMID:20706672
Txn1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOTxn1 (Mus musculus)6480464epigallocatechin gallate affects the expression of and affects the activity of TXN proteinCTDPMID:25585349
Txn1Rat(-)-epigallocatechin 3-gallate increases expressionISOTxn1 (Mus musculus)6480464epigallocatechin gallate results in increased expression of TXN mRNACTDPMID:25585349
Txn1Rat(-)-quinic acid multiple interactionsISOTXN (Homo sapiens)6480464[Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of TXN mRNACTDPMID:21751221
Txn1Rat(-)-selegiline affects response to substanceISOTxn1 (Mus musculus)6480464TXN protein affects the susceptibility to SelegilineCTDPMID:16099847
Txn1Rat(-)-selegiline increases expressionISOTxn1 (Mus musculus)6480464Selegiline results in increased expression of TXN proteinCTDPMID:16099847
Txn1Rat(-)-selegiline affects response to substanceISOTXN (Homo sapiens)6480464TXN protein affects the susceptibility to SelegilineCTDPMID:16099847
Txn1Rat(-)-selegiline increases expressionISOTXN (Homo sapiens)6480464Selegiline results in increased expression of TXN proteinCTDPMID:16099847
Txn1Rat(-)-selegiline multiple interactionsISOTXN (Homo sapiens)6480464Dinitrochlorobenzene inhibits the reaction [Selegiline results in increased expression of TXN] more ...CTDPMID:16099847
Txn1Rat(1->4)-beta-D-glucan multiple interactionsISOTxn1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TXN1 mRNACTDPMID:36331819
Txn1Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of TXN1 mRNA and Thioctic Acid inhibits the reaction [Propylthiouracil results in increased expression of TXN1 mRNA]CTDPMID:23830814 and PMID:31068541
Txn1Rat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464[alpha-Tocopherol co-treated with Ascorbic Acid] inhibits the reaction [arsenite results in increased expression of TXN1 protein]CTDPMID:21344382
Txn1Rat(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of TXN1 proteinCTDPMID:28082123
Txn1Rat(S)-nicotine multiple interactionsEXP 64804642-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]] more ...CTDPMID:28082123
Txn1Rat(S)-nicotine multiple interactionsISOTxn1 (Mus musculus)6480464Nicotine inhibits the reaction [1-Methyl-4-phenyl-1 more ...CTDPMID:28082123
Txn1Rat1,1'-azobis(N,N-dimethylformamide) increases oxidationISOTXN (Homo sapiens)6480464Diamide results in increased oxidation of TXN proteinCTDPMID:26975474
Txn1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of TXN1 mRNACTDPMID:17984292
Txn1Rat1,2-dimethylhydrazine multiple interactionsISOTxn1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TXN1 mRNACTDPMID:22206623
Txn1Rat1,4-dithiothreitol multiple interactionsISOTXN (Homo sapiens)6480464Dithiothreitol inhibits the reaction [NCX 4040 inhibits the reaction [TXN1 protein binds to MAP3K5 protein]]CTDPMID:18922898
Txn1Rat1-chloro-2,4-dinitrobenzene multiple interactionsISOTXN (Homo sapiens)6480464Dinitrochlorobenzene inhibits the reaction [Selegiline results in increased expression of TXN] and Dinitrochlorobenzene inhibits the reaction [TXN protein affects the susceptibility to Selegiline]CTDPMID:16099847

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Biological Process
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Original Reference(s)
Txn1Ratcell redox homeostasis involved_inISOTXN (Homo sapiens)1624291 PMID:2176490 and PMID:9108029RGDPMID:2176490 and PMID:9108029
Txn1Ratcell redox homeostasis acts_upstream_of_or_withinISOTxn1 (Mus musculus)1624291 PMID:18555775RGDPMID:18555775
Txn1Ratcellular detoxification of hydrogen peroxide involved_inISOTXN (Homo sapiens)1624291UniProtKB:Q99497 and PMID:22492997RGDPMID:22492997
Txn1Ratcellular response to antibiotic  IEP 5133706minocyclineRGD 
Txn1Ratcellular response to glucose stimulus  IEP 5133719 RGD 
Txn1Ratcellular response to hyperoxia  IEP 5133704 RGD 
Txn1Ratcellular response to xenobiotic stimulus  IEP 5133719dipyridamoleRGD 
Txn1Ratnegative regulation of protein export from nucleus acts_upstream_of_or_withinISOTxn1 (Mus musculus)1624291 PMID:18555775RGDPMID:18555775
Txn1Ratnegative regulation of transcription by RNA polymerase II acts_upstream_of_or_withinISOTxn1 (Mus musculus)1624291MGI:1889549 more ...RGDPMID:18555775
Txn1Ratpositive regulation of peptidyl-cysteine S-nitrosylation involved_inISOTXN (Homo sapiens)1624291 PMID:16408020 more ...RGDPMID:16408020 more ...
Txn1Ratpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction involved_inISOTXN (Homo sapiens)1624291 PMID:22492997RGDPMID:22492997
Txn1Ratresponse to activity  IEP 5133713 RGD 
Txn1Ratresponse to axon injury  IEP 5133729 RGD 
Txn1Ratresponse to dexamethasone  IEP 5133720 RGD 
Txn1Ratresponse to nitric oxide involved_inISOTXN (Homo sapiens)1624291 PMID:16408020 and PMID:17606900RGDPMID:16408020 and PMID:17606900
Txn1Ratresponse to radiation involved_inISSUniProtKB:P105991600115GO_REF:0000024UniProtGO_REF:0000024
Txn1Ratresponse to radiation involved_inISOTXN (Homo sapiens)1624291 PMID:11118054 and PMID:9108029RGDPMID:11118054 and PMID:9108029
Txn1Ratresponse to selenium ion  IEP 5133718 RGD 
Txn1Ratresponse to thyroxine  IEP 5133711 RGD 
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Cellular Component
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Object Symbol
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Original Reference(s)
Txn1Rataxon  IDA 5133712 RGD 
Txn1Ratcytoplasm located_inISOTXN (Homo sapiens)1624291 PMID:9108029RGDPMID:9108029
Txn1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Txn1Ratcytoplasm located_inISOTxn1 (Mus musculus)1624291 PMID:11213470RGDPMID:11213470
Txn1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Txn1Ratcytosol located_inISOTXN (Homo sapiens) and UniProtKB:P10599-11624291 RGDGO_REF:0000052
Txn1Ratcytosol located_inISOTxn1 (Mus musculus)1624291 PMID:18555775RGDPMID:18555775
Txn1Ratdendrite  IDA 5133712 RGD 
Txn1Ratextracellular region located_inISOTXN (Homo sapiens)1624291 PMID:1332947RGDPMID:1332947
Txn1Ratextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
Txn1Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Txn1Ratneuronal cell body  IDA 5133712 RGD 
Txn1Ratnucleoplasm located_inISOTXN (Homo sapiens) and UniProtKB:P10599-11624291 RGDGO_REF:0000052
Txn1Ratnucleus located_inISOTXN (Homo sapiens)1624291 PMID:9108029RGDPMID:9108029
Txn1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Txn1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Txn1Ratnucleus located_inISOTxn1 (Mus musculus)1624291 PMID:11213470 and PMID:18555775RGDPMID:11213470 and PMID:18555775
1 to 17 of 17 rows

Imported Annotations - SMPDB

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Imported Annotations - PID (archival)

Object Symbol
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Evidence
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Reference
Notes
Source
Original Reference(s)
Txn1Ratp38 MAPK signaling pathway   ISOTXN (Homo sapiens)6484113 PIDPID:200018
Txn1Rattumor necrosis factor mediated signaling pathway   ISOTXN (Homo sapiens)6484113 PIDPID:200102

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#
Reference Title
Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Redox regulation of myocardial ERK 1/2 phosphorylation in experimental hyperthyroidism: role of thioredoxin-peroxiredoxin system. Araujo AS, etal., J Cardiovasc Pharmacol. 2010 Nov;56(5):513-7.
3. Redox regulation of resveratrol-mediated switching of death signal into survival signal. Das S, etal., Free Radic Biol Med. 2008 Jan 1;44(1):82-90. Epub 2007 Sep 21.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Severe liver steatosis correlates with nitrosative and oxidative stress in rats. Grattagliano I, etal., Eur J Clin Invest. 2008 Jul;38(7):523-30.
6. Simultaneous expression of glutathione, thioredoxin-1, and their reductases in nerve transected hypoglossal motor neurons of rat. Hama I, etal., Brain Res. 2010 Jan 8;1306:1-7. Epub 2009 Oct 13.
7. Plasma thioredoxin levels in patients with unstable angina. Hokamaki J, etal., Int J Cardiol. 2005 Mar 18;99(2):225-31.
8. Dipyridamole suppresses high glucose-induced osteopontin secretion and mRNA expression in rat aortic smooth muscle cells. Hsieh MS, etal., Circ J. 2010 Jun;74(6):1242-50. Epub 2010 Apr 20.
9. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Jia J, etal., Thromb Res. 2009 Mar;123(5):727-30. Epub 2009 Jan 6.
10. Antioxidant defenses in the rat placenta in late gestation: increased labyrinthine expression of superoxide dismutases, glutathione peroxidase 3, and uncoupling protein 2. Jones ML, etal., Biol Reprod. 2010 Aug 1;83(2):254-60. Epub 2010 Apr 14.
11. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
12. Acute exercise and thioredoxin-1 in rat brain, and alpha-lipoic acid and thioredoxin-interacting protein response, in diabetes. Lappalainen Z, etal., Int J Sport Nutr Exerc Metab. 2010 Jun;20(3):206-15.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Nucleolin binds to a subset of selenoprotein mRNAs and regulates their expression. Miniard AC, etal., Nucleic Acids Res. 2010 Aug;38(14):4807-20. Epub 2010 Apr 12.
15. Redox proteins thioredoxin 1 and thioredoxin 2 support retinal ganglion cell survival in experimental glaucoma. Munemasa Y, etal., Gene Ther. 2009 Jan;16(1):17-25. Epub 2008 Aug 14.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Upregulation of redox-regulating protein, thioredoxin, in endomyocardial biopsy samples of patients with myocarditis and cardiomyopathies. Nimata M, etal., Mol Cell Biochem. 2003 Jun;248(1-2):193-6.
18. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
19. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
20. GOA pipeline RGD automated data pipeline
1 to 20 of 32 rows
PMID:1332947   PMID:2176490   PMID:2734107   PMID:9108029   PMID:9369469   PMID:11118054   PMID:11213470   PMID:13679060   PMID:14651853   PMID:15123525   PMID:15128745   PMID:15489334  
PMID:15723974   PMID:16408020   PMID:17023680   PMID:17130129   PMID:17182577   PMID:17256724   PMID:17260951   PMID:17360810   PMID:17606900   PMID:18555775   PMID:18614015   PMID:19032234  
PMID:19056867   PMID:19074570   PMID:19940280   PMID:20238036   PMID:20458337   PMID:20558743   PMID:20709139   PMID:21586560   PMID:22165200   PMID:22342837   PMID:22492997   PMID:22658674  
PMID:22681889   PMID:22732447   PMID:22871113   PMID:23376485   PMID:23533145   PMID:23846223   PMID:24578161   PMID:24925443   PMID:25055978   PMID:25451293   PMID:25486571   PMID:25541364  
PMID:25735211   PMID:25957836   PMID:26327811   PMID:26346161   PMID:26846911   PMID:26975474   PMID:27052476   PMID:27894668   PMID:28659344   PMID:28939765   PMID:29036266   PMID:29328386  
PMID:31276937   PMID:31547465   PMID:31785355   PMID:31904090   PMID:33161477   PMID:33450132   PMID:34132424   PMID:35072836   PMID:37196136   PMID:37816196   PMID:38976128  



Txn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8577,507,455 - 77,519,685 (-)NCBIGRCr8
mRatBN7.2572,712,334 - 72,724,564 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl572,711,933 - 72,724,629 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx574,603,651 - 74,615,881 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0576,425,269 - 76,437,499 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0576,397,400 - 76,409,630 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0575,049,735 - 75,057,731 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0579,201,386 - 79,209,384 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4575,921,365 - 75,933,595 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1575,926,428 - 75,938,789 (-)NCBI
Celera571,558,162 - 71,570,393 (-)NCBICelera
RH 3.4 Map5494.0RGD
Cytogenetic Map5q24NCBI
TXN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389110,243,810 - 110,256,507 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9110,243,810 - 110,256,507 (-)EnsemblGRCh38hg38GRCh38
GRCh379113,006,090 - 113,018,787 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369112,046,131 - 112,058,599 (-)NCBINCBI36Build 36hg18NCBI36
Build 349110,085,864 - 110,098,333NCBI
Celera983,507,936 - 83,520,398 (-)NCBICelera
Cytogenetic Map9q31.3NCBI
HuRef982,607,811 - 82,620,710 (-)NCBIHuRef
CHM1_19113,152,543 - 113,165,343 (-)NCBICHM1_1
T2T-CHM13v2.09122,413,340 - 122,426,045 (-)NCBIT2T-CHM13v2.0
Txn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39457,943,373 - 57,956,411 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm39 Ensembl
GRCm38457,943,373 - 57,956,411 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl457,943,373 - 57,956,411 (-)EnsemblGRCm38mm10GRCm38
MGSCv37457,956,245 - 57,969,283 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36458,037,427 - 58,050,345 (-)NCBIMGSCv36mm8
Celera457,856,035 - 57,868,968 (-)NCBICelera
Cytogenetic Map4B3NCBI
cM Map431.87NCBI
TXN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21129,150,207 - 29,162,897 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1929,152,695 - 29,165,262 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0981,399,056 - 81,411,607 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19109,565,557 - 109,578,311 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9109,565,557 - 109,578,311 (-)Ensemblpanpan1.1panPan2
LOC100687127
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X82,986,288 - 82,986,753 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX69,064,524 - 69,064,989 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X84,637,255 - 84,637,720 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X82,113,902 - 82,114,367 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X83,808,036 - 83,808,501 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X83,636,876 - 83,637,341 (-)NCBIUU_Cfam_GSD_1.0
Txn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947180,444,054 - 180,454,833 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365592,811,782 - 2,822,528 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365592,811,786 - 2,822,528 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1251,263,175 - 251,277,988 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11251,264,180 - 251,278,000 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21282,027,082 - 282,035,642 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap1qNCBI
TXN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11229,296,166 - 29,308,979 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603513,456,569 - 13,469,439 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247581,318,529 - 1,329,011 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247581,318,108 - 1,329,011 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Txn1
32 total Variants

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:87
Interacting mature miRNAs:95
Transcripts:ENSRNOT00000016447
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 44 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578776Stresp18Stress response QTL 182.9thymus mass (VT:0004954)thymus wet weight (CMO:0000855)52795544072955440Rat
1298067Scl15Serum cholesterol level QTL 154.80.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)53321566578215665Rat
1300115Hrtrt7Heart rate QTL 72.76heart pumping trait (VT:2000009)heart rate (CMO:0000002)54786906290099692Rat
1357396Bw44Body weight QTL 444.19body mass (VT:0001259)body weight (CMO:0000012)568984307104251008Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
61380Edpm5Estrogen-dependent pituitary mass QTL 54.50.92pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)568984307104251008Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1358353Srcrtb2Stress Responsive Cort Basal QTL 23.480.003blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)51887394774251464Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61386Bp49Blood pressure QTL 4916.6cerebrum integrity trait (VT:0010549)brain infarction volume (CMO:0001013)56029343498603051Rat

1 to 10 of 44 rows
AW550880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2572,720,241 - 72,720,334 (+)MAPPERmRatBN7.2
Rnor_6.0575,057,643 - 75,057,735NCBIRnor6.0
Rnor_5.0579,209,294 - 79,209,386UniSTSRnor5.0
RGSC_v3.4575,929,273 - 75,929,365UniSTSRGSC3.4
Celera571,566,069 - 71,566,161UniSTS
Cytogenetic Map5q24UniSTS
RH94605  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2572,712,236 - 72,712,336 (+)MAPPERmRatBN7.2
Rnor_6.0575,049,638 - 75,049,737NCBIRnor6.0
Rnor_5.0579,201,289 - 79,201,388UniSTSRnor5.0
RGSC_v3.4575,921,268 - 75,921,367UniSTSRGSC3.4
Celera571,558,065 - 71,558,164UniSTS
RH 3.4 Map5494.0UniSTS
Cytogenetic Map5q24UniSTS
BQ201341  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2572,726,259 - 72,726,452 (+)MAPPERmRatBN7.2
Rnor_6.0575,064,192 - 75,064,384NCBIRnor6.0
Rnor_5.0579,215,618 - 79,215,810UniSTSRnor5.0
RGSC_v3.4575,935,240 - 75,935,432UniSTSRGSC3.4
Celera571,572,084 - 71,572,276UniSTS
RH 3.4 Map5495.8UniSTS
Cytogenetic Map5q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000016447   ⟹   ENSRNOP00000016447
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl572,711,933 - 72,724,629 (-)Ensembl
Rnor_6.0 Ensembl575,049,747 - 75,057,752 (-)Ensembl
RefSeq Acc Id: NM_053800   ⟹   NP_446252
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8577,507,455 - 77,519,685 (-)NCBI
mRatBN7.2572,712,334 - 72,724,564 (-)NCBI
Rnor_6.0575,049,735 - 75,057,731 (-)NCBI
Rnor_5.0579,201,386 - 79,209,384 (-)NCBI
RGSC_v3.4575,921,365 - 75,933,595 (-)RGD
Celera571,558,162 - 71,570,393 (-)RGD
Sequence:
Protein RefSeqs NP_446252 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG49923 (Get FASTA)   NCBI Sequence Viewer  
  AAH58454 (Get FASTA)   NCBI Sequence Viewer  
  EDL91664 (Get FASTA)   NCBI Sequence Viewer  
  P11232 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446252   ⟸   NM_053800
- UniProtKB: P11232 (UniProtKB/Swiss-Prot),   A6KDU1 (UniProtKB/TrEMBL),   R4GNK3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016447   ⟸   ENSRNOT00000016447
Thioredoxin

Name Modeler Protein Id AA Range Protein Structure
AF-P11232-F1-model_v2 AlphaFold P11232 1-105 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 24 of 24 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-41194 BioCyc
Ensembl Genes ENSRNOG00000012081 Ensembl
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6886988 IMAGE-MGC_LOAD
InterPro Thioredoxin UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_CS UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:116484 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72735 IMAGE-MGC_LOAD
NCBI Gene 116484 ENTREZGENE
PANTHER THIOREDOXIN-LIKE PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Thioredoxin UniProtKB/Swiss-Prot
PhenoGen Txn1 PhenoGen
PIRSF Thioredoxin UniProtKB/Swiss-Prot
PRINTS THIOREDOXIN UniProtKB/Swiss-Prot
PROSITE THIOREDOXIN_1 UniProtKB/Swiss-Prot
  THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000012081 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A6KDU1 ENTREZGENE, UniProtKB/TrEMBL
  P11232 ENTREZGENE
  R4GNK3 ENTREZGENE, UniProtKB/TrEMBL
  THIO_RAT UniProtKB/Swiss-Prot
1 to 24 of 24 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Txn1  thioredoxin 1  Txn  thioredoxin  Symbol and Name updated 1299863 APPROVED

Note Type Note Reference
gene_regulation regulated by vitamin D(3)-up-regulated protein-1 727213