Psmc1 (proteasome 26S subunit, ATPase 1) - Rat Genome Database

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Gene: Psmc1 (proteasome 26S subunit, ATPase 1) Rattus norvegicus
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Symbol: Psmc1
Name: proteasome 26S subunit, ATPase 1
RGD ID: 621097
Description: Enables TBP-class protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of proteasome regulatory particle, base subcomplex. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss. Orthologous to human PSMC1 (proteasome 26S subunit, ATPase 1); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-nitrofluorene; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 26S protease regulatory subunit 4; 26S proteasome AAA-ATPase subunit RPT2; 26S proteasome regulatory subunit 4; P26s4; peptidase (prosome, macropain) 26S subunit, ATPase 1; protease (prosome, macropain) 26S subunit, ATPase 1; proteasome (prosome, macropain) 26S subunit, ATPase, 1; proteasome 26S subunit ATPase 1; s4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86125,122,497 - 125,134,859 (+)NCBIGRCr8
mRatBN7.26119,392,833 - 119,405,233 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6119,392,855 - 119,410,123 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6119,555,520 - 119,567,890 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06119,852,325 - 119,864,695 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06119,187,189 - 119,199,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06124,123,283 - 124,135,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6124,123,228 - 124,135,658 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06133,350,578 - 133,362,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46124,380,976 - 124,393,338 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16124,384,722 - 124,397,084 (+)NCBI
Celera6116,922,860 - 116,935,222 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psmc1Ratachondrogenesis type IA  ISOPSMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Achondrogenesis and type IAClinVarPMID:28492532
Psmc1Ratneurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss  ISOPSMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorder with poor growth more ...ClinVarPMID:35861243
Psmc1Ratprostate cancer  ISOPSMC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psmc1Ratneurodevelopmental disorder with poor growth, spastic tetraplegia, and hearing loss  ISOPSMC1 (Homo sapiens)7240710 OMIM 

1 to 20 of 105 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psmc1Rat1,2-dichloroethane increases expressionISOPsmc1 (Mus musculus)6480464ethylene dichloride results in increased expression of PSMC1 mRNACTDPMID:28960355
Psmc1Rat1,2-dimethylhydrazine increases expressionISOPsmc1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PSMC1 mRNACTDPMID:22206623
Psmc1Rat1,2-dimethylhydrazine multiple interactionsISOPsmc1 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of PSMC1 mRNA]CTDPMID:22206623
Psmc1Rat17alpha-ethynylestradiol increases expressionISOPsmc1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of PSMC1 mRNACTDPMID:17942748
Psmc1Rat17beta-estradiol increases expressionISOPsmc1 (Mus musculus)6480464Estradiol results in increased expression of PSMC1 mRNACTDPMID:39298647
Psmc1Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expressionISOPSMC1 (Homo sapiens)6480464Metribolone results in increased expression of PSMC1 proteinCTDPMID:17152098
Psmc1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPsmc1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PSMC1 mRNACTDPMID:21570461
Psmc1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PSMC1 mRNACTDPMID:34747641
Psmc1Rat2-bromohexadecanoic acid multiple interactionsISOPSMC1 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of PSMC1 protein]CTDPMID:38195004
Psmc1Rat2-nitrofluorene increases expressionEXP 64804642-nitrofluorene results in increased expression of PSMC1 mRNACTDPMID:15890375
Psmc1Rat3H-1,2-dithiole-3-thione increases expressionISOPsmc1 (Mus musculus)64804641 and 2-dithiol-3-thione results in increased expression of PSMC1 mRNACTDPMID:15375163
Psmc1Rat4,4'-diaminodiphenylmethane decreases expressionISOPsmc1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of PSMC1 mRNACTDPMID:18648102
Psmc1Rat4,4'-sulfonyldiphenol increases expressionISOPsmc1 (Mus musculus)6480464bisphenol S results in increased expression of PSMC1 mRNACTDPMID:39298647
Psmc1Rat4,4'-sulfonyldiphenol increases expressionISOPSMC1 (Homo sapiens)6480464bisphenol S results in increased expression of PSMC1 proteinCTDPMID:34186270
Psmc1Rat4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expressionEXP 64804644-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of PSMC1 mRNACTDPMID:15890375
Psmc1Rat5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole affects expressionEXP 6480464Omeprazole affects the expression of PSMC1 mRNACTDPMID:19483382
Psmc1Rat6-propyl-2-thiouracil affects expressionEXP 6480464Propylthiouracil affects the expression of PSMC1 mRNACTDPMID:19483382
Psmc1Ratacrylamide increases expressionISOPSMC1 (Homo sapiens)6480464Acrylamide results in increased expression of PSMC1 mRNACTDPMID:32763439
Psmc1Rataflatoxin B1 increases expressionEXP 6480464Aflatoxin B1 results in increased expression of PSMC1 mRNACTDPMID:15890375
Psmc1Ratamiodarone affects expressionEXP 6480464Amiodarone affects the expression of PSMC1 mRNACTDPMID:19483382

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Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psmc1Ratbiological_process  ND 159840702/2010: no relevant rat dataRGD 
Psmc1Ratpositive regulation of proteasomal protein catabolic process involved_inIEAGO:00364021600115GO_REF:0000108GOCGO_REF:0000108
Psmc1Ratproteasome-mediated ubiquitin-dependent protein catabolic process involved_inIBAFB:FBgn0015282 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Cellular Component
1 to 20 of 21 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psmc1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Psmc1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Psmc1Ratcytosol located_inISOPSMC1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Psmc1Ratcytosol located_inIEAUniProtKB:P62191 and ensembl:ENSP000002613031600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc1Ratcytosol located_inIEAUniProtKB:Q53XL8 and ensembl:ENSP000002613031600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Psmc1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Psmc1Ratnucleoplasm located_inISOPSMC1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Psmc1Ratnucleoplasm located_inIEAUniProtKB:Q53XL8 and ensembl:ENSP000002613031600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc1Ratnucleoplasm located_inIEAUniProtKB:P62191 and ensembl:ENSP000002613031600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Psmc1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Psmc1Ratproteasome accessory complex part_ofISSUniProtKB:P621921600115GO_REF:0000024UniProtGO_REF:0000024
Psmc1Ratproteasome accessory complex part_ofISOPsmc1 (Mus musculus)1624291 PMID:16857966RGDPMID:16857966
Psmc1Ratproteasome accessory complex part_ofIEAUniProtKB:P62192 and ensembl:ENSMUSP000000215951600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc1Ratproteasome complex part_ofIEAUniProtKB-KW:KW-06471600115GO_REF:0000043UniProtGO_REF:0000043
Psmc1Ratproteasome complex part_ofIEAUniProtKB:P62191 and ensembl:ENSP000002613031600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc1Ratproteasome complex part_ofISOPSMC1 (Homo sapiens)1624291 PMID:17323924RGDPMID:17323924
Psmc1Ratproteasome regulatory particle part_ofIEAUniProtKB:P62192 and ensembl:ENSMUSP000000215951600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc1Ratproteasome regulatory particle part_ofISOPsmc1 (Mus musculus)1624291 PMID:20498273RGDPMID:20498273
1 to 20 of 21 rows

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psmc1RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Psmc1RatATP binding enablesIEAInterPro:IPR003959 and InterPro:IPR0039601600115GO_REF:0000002InterProGO_REF:0000002
Psmc1RatATP hydrolysis activity  TAS 729492 RGD 
Psmc1RatATP hydrolysis activity enablesIEAInterPro:IPR003593 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Psmc1Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Psmc1Ratproteasome-activating activity enablesIBAPANTHER:PTN000553037 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Psmc1Ratprotein binding enablesISOPSMC1 (Homo sapiens)1624291UniProtKB:O43463 more ...RGDPMID:16189514 more ...
Psmc1RatTBP-class protein binding  IPITbp (Mus musculus)6771232 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Psmc1Ratubiquitin/proteasome degradation pathway  IEA 6907045 KEGGrno:03050

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing. Makino Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):1049-54.
3. Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120. Makino Y, etal., Genes Cells. 1999 Sep;4(9):529-39.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. Comprehensive gene review and curation RGD comprehensive gene curation
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
1 to 11 of 11 rows
PMID:9688553   PMID:15489334   PMID:16857966   PMID:17323924   PMID:19946888   PMID:20498273   PMID:21630459   PMID:22658674   PMID:22871113   PMID:23382946   PMID:24625528   PMID:30053369  
PMID:31904090   PMID:35352799  



Psmc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86125,122,497 - 125,134,859 (+)NCBIGRCr8
mRatBN7.26119,392,833 - 119,405,233 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6119,392,855 - 119,410,123 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6119,555,520 - 119,567,890 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06119,852,325 - 119,864,695 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06119,187,189 - 119,199,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06124,123,283 - 124,135,644 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6124,123,228 - 124,135,658 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06133,350,578 - 133,362,939 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46124,380,976 - 124,393,338 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.16124,384,722 - 124,397,084 (+)NCBI
Celera6116,922,860 - 116,935,222 (+)NCBICelera
Cytogenetic Map6q32NCBI
PSMC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381490,256,553 - 90,275,429 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1490,256,527 - 90,275,429 (+)EnsemblGRCh38hg38GRCh38
GRCh371490,722,897 - 90,741,773 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361489,792,647 - 89,808,719 (+)NCBINCBI36Build 36hg18NCBI36
Build 341489,792,646 - 89,808,719NCBI
Celera1470,770,035 - 70,786,113 (+)NCBICelera
Cytogenetic Map14q32.11NCBI
HuRef1470,897,288 - 70,913,368 (+)NCBIHuRef
CHM1_11490,661,102 - 90,677,177 (+)NCBICHM1_1
T2T-CHM13v2.01484,478,491 - 84,499,697 (+)NCBIT2T-CHM13v2.0
Psmc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912100,076,461 - 100,089,623 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12100,076,413 - 100,089,664 (+)EnsemblGRCm39 Ensembl
GRCm3812100,110,202 - 100,123,364 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12100,110,154 - 100,123,405 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712101,348,412 - 101,361,574 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3612100,511,252 - 100,524,414 (+)NCBIMGSCv36mm8
Celera12101,336,798 - 101,349,996 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1250.43NCBI
Psmc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543812,704,691 - 12,721,050 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543812,705,328 - 12,721,050 (+)NCBIChiLan1.0ChiLan1.0
PSMC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21591,400,672 - 91,416,861 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11490,617,193 - 90,633,367 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01470,873,846 - 70,889,988 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11490,225,405 - 90,241,638 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1490,225,405 - 90,241,641 (+)Ensemblpanpan1.1panPan2
PSMC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1861,272,363 - 61,285,886 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl861,272,363 - 61,285,886 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha860,851,941 - 60,865,464 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0861,544,550 - 61,558,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl861,544,577 - 61,558,051 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1861,225,967 - 61,239,658 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0861,274,899 - 61,288,618 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0861,603,196 - 61,616,721 (+)NCBIUU_Cfam_GSD_1.0
Psmc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864014,600,035 - 14,613,399 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648817,455,461 - 17,469,527 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648817,455,612 - 17,468,933 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl7112,027,921 - 112,041,489 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.17112,027,904 - 112,041,360 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27118,594,314 - 118,607,772 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSMC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12467,979,449 - 67,995,103 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605355,265,330 - 55,281,008 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473412,153,919 - 12,174,650 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Psmc1
69 total Variants

Predicted Target Of
Summary Value
Count of predictions:214
Count of miRNA genes:143
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000005329
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 23 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6104085867128713626Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat

1 to 10 of 23 rows
BE107583  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.26119,403,531 - 119,403,747 (+)MAPPERmRatBN7.2
Rnor_6.06124,133,944 - 124,134,159NCBIRnor6.0
Rnor_5.06133,361,239 - 133,361,454UniSTSRnor5.0
RGSC_v3.46124,391,637 - 124,391,852UniSTSRGSC3.4
Celera6116,933,521 - 116,933,736UniSTS
RH 3.4 Map6856.9UniSTS
Cytogenetic Map6q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000005329   ⟹   ENSRNOP00000005329
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6119,392,855 - 119,405,233 (+)Ensembl
Rnor_6.0 Ensembl6124,123,228 - 124,135,658 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113995   ⟹   ENSRNOP00000095712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6119,393,070 - 119,410,123 (+)Ensembl
RefSeq Acc Id: NM_057123   ⟹   NP_476464
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86125,122,497 - 125,134,859 (+)NCBI
mRatBN7.26119,392,869 - 119,405,233 (+)NCBI
Rnor_6.06124,123,283 - 124,135,644 (+)NCBI
Rnor_5.06133,350,578 - 133,362,939 (+)NCBI
RGSC_v3.46124,380,976 - 124,393,338 (+)RGD
Celera6116,922,860 - 116,935,222 (+)RGD
Sequence:
Protein RefSeqs NP_476464 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH63157 (Get FASTA)   NCBI Sequence Viewer  
  BAA09341 (Get FASTA)   NCBI Sequence Viewer  
  EDL81712 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005329
GenBank Protein P62193 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476464   ⟸   NM_057123
- UniProtKB: P62193 (UniProtKB/Swiss-Prot),   A6JEG8 (UniProtKB/TrEMBL),   A0A8I6APJ8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005329   ⟸   ENSRNOT00000005329
Ensembl Acc Id: ENSRNOP00000095712   ⟸   ENSRNOT00000113995
AAA+ ATPase

Name Modeler Protein Id AA Range Protein Structure
AF-P62193-F1-model_v2 AlphaFold P62193 1-440 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694774
Promoter ID:EPDNEW_R5298
Type:initiation region
Name:Psmc1_1
Description:proteasome 26S subunit, ATPase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06124,123,276 - 124,123,336EPDNEW


1 to 35 of 35 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-36501 BioCyc
Ensembl Genes ENSRNOG00000003951 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000005329 ENTREZGENE
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  2.40.50.140 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6919865 IMAGE-MGC_LOAD
InterPro 26S_Proteasome_ATPase UniProtKB/Swiss-Prot
  AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  NA-bd_OB-fold UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
KEGG Report rno:117263 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72724 IMAGE-MGC_LOAD
NCBI Gene 117263 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
PharmGKB PSMC1 RGD
PhenoGen Psmc1 PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003951 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I6APJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UHV1_RAT UniProtKB/TrEMBL
  A6JEG8 ENTREZGENE, UniProtKB/TrEMBL
  P62193 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P49014 UniProtKB/Swiss-Prot
  Q03527 UniProtKB/Swiss-Prot
  Q96AZ3 UniProtKB/Swiss-Prot
1 to 35 of 35 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Psmc1  proteasome 26S subunit, ATPase 1  Psmc1  proteasome (prosome, macropain) 26S subunit, ATPase, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-12-15 Psmc1  proteasome (prosome, macropain) 26S subunit, ATPase, 1  Psmc1  protease (prosome, macropain) 26S subunit, ATPase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Psmc1  protease (prosome, macropain) 26S subunit, ATPase 1  Psmc1  peptidase (prosome, macropain) 26S subunit, ATPase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Psmc1  peptidase (prosome, macropain) 26S subunit, ATPase 1    protease (prosome, macropain) 26S subunit, ATPase 1  Name updated 1299863 APPROVED
2002-08-07 Psmc1  protease (prosome, macropain) 26S subunit, ATPase 1      Symbol and Name status set to provisional 70820 PROVISIONAL