Bard1 (BRCA1 associated RING domain 1) - Rat Genome Database

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Gene: Bard1 (BRCA1 associated RING domain 1) Rattus norvegicus
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Symbol: Bard1
Name: BRCA1 associated RING domain 1
RGD ID: 621072
Description: Predicted to enable RNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Predicted to contribute to ubiquitin-protein transferase activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to testosterone stimulus; and response to aldosterone. Predicted to be located in cytoplasmic ribonucleoprotein granule and nuclear speck. Predicted to be part of nucleus. Biomarker of retinal degeneration. Human ortholog(s) of this gene implicated in breast cancer and ovarian cancer. Orthologous to human BARD1 (BRCA1 associated RING domain 1); INTERACTS WITH 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BARD-1; BRCA1-associated RING domain protein 1; RING-type E3 ubiquitin transferase BARD1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8980,069,960 - 80,144,167 (-)NCBIGRCr8
mRatBN7.2972,616,070 - 72,694,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx981,082,647 - 81,149,936 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,211,538 - 86,278,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0984,594,537 - 84,662,040 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,297,723 - 78,368,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,294,834 - 78,369,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,074,908 - 78,145,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,120,151 - 70,198,591 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1970,267,132 - 70,345,573 (-)NCBI
Celera970,040,784 - 70,110,644 (-)NCBICelera
Cytogenetic Map9q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Bard1Ratbreast cancer susceptibilityISOBARD1 (Homo sapiens)2315716DNA:polymorphism: :p.C557S (human)RGD 
Bard1Ratbreast cancer no_associationISOBARD1 (Homo sapiens)2315715DNA:polymorphisms: :multiple (human)RGD 
Bard1Ratbreast cancer no_associationISOBARD1 (Homo sapiens)2315717DNA:polymorphisms: :p.V507M and p.C557S (human)RGD 
Bard1Ratbreast cancer susceptibilityISOBARD1 (Homo sapiens)2315729DNA:polymorphism: :p.V507M (human)RGD 
Bard1Ratbreast cancer severityISOBARD1 (Homo sapiens)2315727protein:increased expression and altered localization:breastRGD 
Bard1Ratbreast cancer no_associationISOBARD1 (Homo sapiens)2315714DNA:polymorphism: :p.C557S (human)RGD 
Bard1Ratbreast cancer susceptibilityISOBARD1 (Homo sapiens)2315713DNA:polymorphisms: :p.P24S and p.R378S (human)RGD 
Bard1RatCachexia  IEP 2315732associated with Carcinoma more ...RGD 
Bard1RatExperimental Mammary Neoplasms  ISOBard1 (Mus musculus)2293149 RGD 
Bard1Ratlung non-small cell carcinoma disease_progressionISOBARD1 (Homo sapiens)127229947 RGD 
Bard1Ratovarian cancer  ISOBARD1 (Homo sapiens)2315727DNA more ...RGD 
Bard1Ratretinal degeneration  IEP 152025547associated with hyperaldosterone and mRNA:decreased expression:retina (rat)RGD 
Bard1RatRETINAL DYSTROPHY WITH INNER RETINAL DYSFUNCTION AND GANGLION CELL ABNORMALITIES  IEP 152025547associated with hyperaldosterone and mRNA:decreased expression:retina (rat)RGD 
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Bard1Ratbrain disease  ISOBARD1 (Homo sapiens)8554872ClinVar Annotator: match by term: EncephalopathyClinVarPMID:25741868
Bard1Ratbreast cancer  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1Ratbreast cancer  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1Ratbreast cancer  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1RatBreast Cancer, Familial  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1RatBreast Cancer, Familial  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1RatBreast Cancer, Familial  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:9536098
Bard1Ratbreast carcinoma  ISOBARD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast carcinomaClinVarPMID:1584056 more ...
Bard1RatBreast Neoplasms  ISOBARD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Breast neoplasmClinVarPMID:20077502 more ...
Bard1Ratcolon carcinoma  ISOBARD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Carcinoma of colonClinVarPMID:19197335 more ...
Bard1Ratendometrial carcinoma  ISOBARD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Endometrial carcinomaClinVarPMID:20077502 more ...
Bard1Ratfamilial adenomatous polyposis 2  ISOBARD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial adenomatous polyposis 2ClinVarPMID:25085752 more ...
Bard1RatFamilial Pancreatic Carcinoma  ISOBARD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial pancreatic carcinomaClinVarPMID:25085752 more ...
Bard1Rathepatoblastoma  ISOBARD1 (Homo sapiens)8554872ClinVar Annotator: match by term: HepatoblastomaClinVarPMID:25741868 more ...
Bard1Rathereditary breast ovarian cancer syndrome  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1Rathereditary breast ovarian cancer syndrome  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1Rathereditary breast ovarian cancer syndrome  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1Rathereditary breast ovarian cancer syndrome  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1Rathereditary breast ovarian cancer syndrome  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
Bard1Rathereditary breast ovarian cancer syndrome  ISOBARD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11807980 more ...
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Bard1RatBreast Neoplasms  ISOBARD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Bard1Ratneuroblastoma  ISOBARD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19412175 and PMID:23334666
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Bard1Ratbreast cancer  ISSBard1 (Mus musculus)13592920OMIM:114480MouseDO 
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Bard1Ratbreast cancer susceptibilityISOBARD1 (Homo sapiens)7240710 OMIM 

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Bard1Rat(+)-catechin multiple interactionsISOBARD1 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of BARD1 mRNACTDPMID:24763279
Bard1Rat(-)-demecolcine decreases expressionISOBARD1 (Homo sapiens)6480464Demecolcine results in decreased expression of BARD1 mRNACTDPMID:23649840
Bard1Rat1,2-dichloroethane affects expressionISOBard1 (Mus musculus)6480464ethylene dichloride affects the expression of BARD1 mRNACTDPMID:28960355
Bard1Rat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases expressionEXP 6480464Citalopram results in decreased expression of BARD1 mRNACTDPMID:28467792
Bard1Rat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile decreases expressionISOBARD1 (Homo sapiens)6480464Citalopram results in decreased expression of BARD1 mRNACTDPMID:28467792
Bard1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of BARD1 mRNACTDPMID:30723492
Bard1Rat17beta-estradiol decreases expressionISOBard1 (Mus musculus)6480464Estradiol results in decreased expression of BARD1 mRNACTDPMID:19484750
Bard1Rat17beta-estradiol multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of BARD1 mRNACTDPMID:32741896
Bard1Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464[estradiol 3-benzoate co-treated with [Testosterone co-treated with Estradiol]] results in increased expression of BARD1 mRNACTDPMID:32741896
Bard1Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsISOBard1 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Bard1Rat2,2',4,4'-Tetrabromodiphenyl ether decreases expressionEXP 64804642 more ...CTDPMID:20566336
Bard1Rat2,2',5,5'-tetrachlorobiphenyl multiple interactionsISOBard1 (Mus musculus)6480464[2 more ...CTDPMID:25510870
Bard1Rat2,2',5,5'-tetrachlorobiphenyl increases expressionISOBARD1 (Homo sapiens)64804642 more ...CTDPMID:36804509
Bard1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOBard1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of BARD1 mRNACTDPMID:21570461
Bard1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of BARD1 mRNACTDPMID:32109520
Bard1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOBARD1 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of BARD1 mRNACTDPMID:22574217
Bard1Rat2-hydroxypropanoic acid decreases expressionISOBARD1 (Homo sapiens)6480464Lactic Acid results in decreased expression of BARD1 mRNACTDPMID:30851411
Bard1Rat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:23196670
Bard1Rat3,3',4,4',5-pentachlorobiphenyl decreases expressionISOBARD1 (Homo sapiens)64804643 more ...CTDPMID:29947894
Bard1Rat3,4-methylenedioxymethamphetamine increases expressionISOBard1 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of BARD1 mRNACTDPMID:26251327

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Biological Process
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Bard1Ratcellular response to follicle-stimulating hormone stimulus  IEP 2315734 RGD 
Bard1Ratcellular response to ionizing radiation involved_inISOBARD1 (Homo sapiens)1624291 PMID:14636569RGDPMID:14636569
Bard1Ratcellular response to ionizing radiation involved_inIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratcellular response to oxidative stress  IEP 152025267 RGD 
Bard1Ratcellular response to testosterone stimulus  IEP 2315734 RGD 
Bard1RatDNA damage response involved_inIEAUniProtKB-KW:KW-02271600115GO_REF:0000043UniProtGO_REF:0000043
Bard1RatDNA repair involved_inIEAUniProtKB-KW:KW-02341600115GO_REF:0000043UniProtGO_REF:0000043
Bard1Ratnegative regulation of apoptotic process involved_inIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratnegative regulation of apoptotic process involved_inISOBARD1 (Homo sapiens)1624291 PMID:15265711RGDPMID:15265711
Bard1Ratnegative regulation of apoptotic process involved_inISSUniProtKB:Q997281600115GO_REF:0000024UniProtGO_REF:0000024
Bard1Ratnegative regulation of protein export from nucleus involved_inISOBARD1 (Homo sapiens)1624291 PMID:15265711RGDPMID:15265711
Bard1Ratnegative regulation of protein export from nucleus involved_inIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratnegative regulation of protein export from nucleus involved_inISSUniProtKB:Q997281600115GO_REF:0000024UniProtGO_REF:0000024
Bard1Ratpositive regulation of apoptotic process involved_inIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratpositive regulation of apoptotic process  IDA 2315734 RGD 
Bard1Ratpositive regulation of apoptotic process involved_inISOBARD1 (Homo sapiens)1624291 PMID:15782130RGDPMID:15782130
Bard1Ratpositive regulation of apoptotic process involved_inISSUniProtKB:Q997281600115GO_REF:0000024UniProtGO_REF:0000024
Bard1Ratprotein K6-linked ubiquitination involved_inISSUniProtKB:Q997281600115GO_REF:0000024UniProtGO_REF:0000024
Bard1Ratprotein K6-linked ubiquitination involved_inIBAPANTHER:PTN008607670 and UniProtKB:Q997281600115GO_REF:0000033GO_CentralGO_REF:0000033
Bard1Ratprotein K6-linked ubiquitination involved_inISOBARD1 (Homo sapiens)1624291 PMID:12890688 and PMID:20351172RGDPMID:12890688 and PMID:20351172
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Cellular Component
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Bard1RatBRCA1-A complex part_ofISOBARD1 (Homo sapiens)1624291 PMID:17525342 more ...RGDPMID:17525342 more ...
Bard1RatBRCA1-A complex part_ofIBAPANTHER:PTN008607670 and UniProtKB:Q997281600115GO_REF:0000033GO_CentralGO_REF:0000033
Bard1RatBRCA1-A complex part_ofIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1RatBRCA1-B complex part_ofISOBARD1 (Homo sapiens)1624291 PMID:16391231RGDPMID:16391231
Bard1RatBRCA1-B complex part_ofIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1RatBRCA1-BARD1 complex part_ofISOBARD1 (Homo sapiens)1624291 PMID:11573085 more ...RGDPMID:11573085 more ...
Bard1RatBRCA1-BARD1 complex part_ofIBAPANTHER:PTN008607670 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Bard1RatBRCA1-BARD1 complex part_ofIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1RatBRCA1-BARD1 complex part_ofISSUniProtKB:Q997281600115GO_REF:0000024UniProtGO_REF:0000024
Bard1RatBRCA1-C complex part_ofISOBARD1 (Homo sapiens)1624291 PMID:16391231RGDPMID:16391231
Bard1RatBRCA1-C complex part_ofIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Bard1Ratcytoplasm located_inIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Bard1Ratcytoplasm located_inISOBARD1 (Homo sapiens)1624291 PMID:15265711RGDPMID:15265711
Bard1Ratcytoplasm located_inISSUniProtKB:Q997281600115GO_REF:0000024UniProtGO_REF:0000024
Bard1Ratcytoplasmic ribonucleoprotein granule located_inIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratcytoplasmic ribonucleoprotein granule located_inISOBARD1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Bard1Ratnuclear speck located_inIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratnuclear speck located_inISOBARD1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
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Molecular Function
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Bard1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Bard1Ratprotein binding enablesISOBARD1 (Homo sapiens)1624291UniProtKB:O00471 more ...RGDPMID:10026184 more ...
Bard1Ratprotein binding enablesISOBARD1 (Homo sapiens) and UniProtKB:Q99728-11624291UniProtKB:Q13526 and PMID:31270457RGDPMID:31270457
Bard1Ratprotein heterodimerization activity enablesIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratprotein heterodimerization activity enablesISOBARD1 (Homo sapiens)1624291UniProtKB:P38398 and PMID:15265711RGDPMID:15265711
Bard1Ratprotein homodimerization activity enablesISSUniProtKB:Q997281600115GO_REF:0000024UniProtGO_REF:0000024
Bard1Ratprotein homodimerization activity enablesISOBARD1 (Homo sapiens)1624291UniProtKB:Q99728 and PMID:15265711RGDPMID:15265711
Bard1Ratprotein homodimerization activity enablesIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1RatRNA binding enablesIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1RatRNA binding enablesISOBARD1 (Homo sapiens)1624291 PMID:12419249RGDPMID:12419249
Bard1Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
Bard1Ratubiquitin-protein transferase activity contributes_toISOBARD1 (Homo sapiens)1624291 PMID:12890688 and PMID:20351172RGDPMID:12890688 and PMID:20351172
Bard1Ratubiquitin-protein transferase activity contributes_toIEAUniProtKB:Q99728 and ensembl:ENSP000002609471600115GO_REF:0000107EnsemblGO_REF:0000107
Bard1Ratubiquitin-protein transferase activity contributes_toIBAPANTHER:PTN008607670 and UniProtKB:Q997281600115GO_REF:0000033GO_CentralGO_REF:0000033
Bard1Ratubiquitin-protein transferase activity contributes_toISSUniProtKB:Q997281600115GO_REF:0000024UniProtGO_REF:0000024
Bard1Ratzinc ion binding enablesIEAUniProtKB-KW:KW-08631600115GO_REF:0000043UniProtGO_REF:0000043
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Reference Title
Reference Citation
1. BARD1 expression during spermatogenesis is associated with apoptosis and hormonally regulated. Feki A, etal., Biol Reprod. 2004 Nov;71(5):1614-24. Epub 2004 Jul 7.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a potential factor in the antitumoral response mediated by apoptotic bodies. Gautier F, etal., Cancer Res 2000 Dec 15;60(24):6895-900.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. BARD1 variants are not associated with breast cancer risk in Australian familial breast cancer. Gorringe KL, etal., Breast Cancer Res Treat. 2008 Oct;111(3):505-9. Epub 2007 Oct 31.
6. Assignment of the BRCA1-associated RING domain gene (Bard1) to rat chromosome 9q34 by in situ hybridization and radiation hybrid mapping. Gratas C, etal., Cytogenet Cell Genet 2001;94(3-4):250-1.
7. Common non-synonymous polymorphisms in the BRCA1 Associated RING Domain (BARD1) gene are associated with breast cancer susceptibility: a case-control analysis. Huo X, etal., Breast Cancer Res Treat. 2007 May;102(3):329-37. Epub 2006 Sep 21.
8. BARD1 content correlates with increased DNA fragmentation associated with muscle wasting in tumour-bearing rats. Irminger-Finger I, etal., Oncol Rep. 2006 Jun;15(6):1425-8.
9. Mutational analysis of BARD1 in familial breast cancer patients in Japan. Ishitobi M, etal., Cancer Lett. 2003 Oct 8;200(1):1-7.
10. BARD1 and breast cancer in Poland. Jakubowska A, etal., Breast Cancer Res Treat. 2008 Jan;107(1):119-22. Epub 2007 Feb 27.
11. Effect of propofol on cardiac function and gene expression after ischemic-reperfusion in isolated rat heart. Kim YJ, etal., Korean J Anesthesiol. 2010 Feb;58(2):153-61. doi: 10.4097/kjae.2010.58.2.153. Epub 2010 Feb 28.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. Gene expression changes in the retina after systemic administration of aldosterone. Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Assessment of citalopram and escitalopram on neuroblastoma cell lines. Cell toxicity and gene modulation. Sakka L, etal., Oncotarget. 2017 Jun 27;8(26):42789-42807. doi: 10.18632/oncotarget.17050.
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PMID:11555636   PMID:12419249   PMID:12890688   PMID:15265711   PMID:15632137   PMID:15782130   PMID:17525342   PMID:19117993   PMID:19261748   PMID:19261749   PMID:20351172  



Bard1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8980,069,960 - 80,144,167 (-)NCBIGRCr8
mRatBN7.2972,616,070 - 72,694,553 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx981,082,647 - 81,149,936 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0986,211,538 - 86,278,825 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0984,594,537 - 84,662,040 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0978,297,723 - 78,368,777 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl978,294,834 - 78,369,031 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0978,074,908 - 78,145,962 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4970,120,151 - 70,198,591 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1970,267,132 - 70,345,573 (-)NCBI
Celera970,040,784 - 70,110,644 (-)NCBICelera
Cytogenetic Map9q33NCBI
BARD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382214,725,646 - 214,809,683 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2214,725,646 - 214,809,683 (-)EnsemblGRCh38hg38GRCh38
GRCh372215,590,370 - 215,674,407 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362215,301,507 - 215,382,673 (-)NCBINCBI36Build 36hg18NCBI36
Build 342215,418,782 - 215,499,872NCBI
Celera2209,361,498 - 209,442,679 (-)NCBICelera
Cytogenetic Map2q35NCBI
HuRef2207,449,412 - 207,530,541 (-)NCBIHuRef
CHM1_12215,599,651 - 215,680,793 (-)NCBICHM1_1
T2T-CHM13v2.02215,210,222 - 215,294,294 (-)NCBIT2T-CHM13v2.0
Bard1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39171,066,694 - 71,142,300 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl171,066,657 - 71,142,305 (-)EnsemblGRCm39 Ensembl
GRCm38171,027,535 - 71,103,141 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl171,027,498 - 71,103,146 (-)EnsemblGRCm38mm10GRCm38
MGSCv37171,074,109 - 71,149,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36170,963,575 - 71,036,126 (-)NCBIMGSCv36mm8
Celera171,583,694 - 71,658,621 (-)NCBICelera
Cytogenetic Map1C3NCBI
cM Map135.67NCBI
Bard1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554571,187,942 - 1,253,803 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554571,187,942 - 1,258,475 (+)NCBIChiLan1.0ChiLan1.0
BARD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213117,351,232 - 117,435,613 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B117,366,194 - 117,450,575 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B101,984,287 - 102,068,523 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B220,456,972 - 220,541,145 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B220,456,972 - 220,541,145 (-)Ensemblpanpan1.1panPan2
LOC102156002
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.182,420,559 - 2,423,280 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha82,362,772 - 2,365,405 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.082,529,629 - 2,532,157 (-)NCBIROS_Cfam_1.0
UNSW_CanFamBas_1.082,279,602 - 2,282,127 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.082,546,112 - 2,548,640 (-)NCBIUU_Cfam_GSD_1.0
Bard1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303170,353,079 - 170,425,653 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365862,200,205 - 2,273,307 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365862,200,211 - 2,272,781 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BARD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15117,047,845 - 117,175,851 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115117,049,483 - 117,135,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215129,595,080 - 129,678,129 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BARD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110100,539,827 - 100,627,718 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10100,539,527 - 100,627,675 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604098,755,214 - 98,840,147 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bard1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247651,351,273 - 1,422,587 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247651,354,511 - 1,419,364 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Bard1
299 total Variants

Predicted Target Of
Summary Value
Count of predictions:98
Count of miRNA genes:86
Interacting mature miRNAs:89
Transcripts:ENSRNOT00000020414
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 28 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
61385Edpm9Estrogen-dependent pituitary mass QTL 93.430.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)963869687108869687Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
1578760Cm53Cardiac mass QTL 533.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)956771635101771635Rat
1581580Uae34Urinary albumin excretion QTL 34urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)96207227596470995Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat

1 to 10 of 28 rows
D9Rat155  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8980,074,851 - 80,075,066 (+)Marker Load Pipeline
mRatBN7.2972,625,378 - 72,625,593 (+)MAPPERmRatBN7.2
Rnor_6.0978,299,947 - 78,300,161NCBIRnor6.0
Rnor_5.0978,077,132 - 78,077,346UniSTSRnor5.0
RGSC_v3.4970,122,374 - 70,122,589RGDRGSC3.4
RGSC_v3.4970,122,375 - 70,122,589UniSTSRGSC3.4
RGSC_v3.1970,269,356 - 70,269,571RGD
Celera970,043,008 - 70,043,222UniSTS
SHRSP x BN Map950.0498UniSTS
SHRSP x BN Map950.0498RGD
Cytogenetic Map9q33UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 113 90 89 58 25 58 6 216 96 93 45 60 31



Ensembl Acc Id: ENSRNOT00000020414   ⟹   ENSRNOP00000020414
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl972,623,178 - 72,694,265 (-)Ensembl
Rnor_6.0 Ensembl978,297,871 - 78,368,777 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000087870   ⟹   ENSRNOP00000075183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)Ensembl
Rnor_6.0 Ensembl978,294,834 - 78,369,031 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106928   ⟹   ENSRNOP00000097768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl972,623,155 - 72,674,328 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000116643   ⟹   ENSRNOP00000079501
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119929   ⟹   ENSRNOP00000088768
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl972,623,155 - 72,694,265 (-)Ensembl
RefSeq Acc Id: NM_022622   ⟹   NP_072144
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,960 - 80,143,755 (-)NCBI
mRatBN7.2972,620,487 - 72,694,285 (-)NCBI
Rnor_6.0978,297,723 - 78,368,777 (-)NCBI
Rnor_5.0978,074,908 - 78,145,962 (-)NCBI
RGSC_v3.4970,120,151 - 70,198,591 (-)RGD
Celera970,040,784 - 70,110,644 (-)RGD
Sequence:
RefSeq Acc Id: XM_039084173   ⟹   XP_038940101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
mRatBN7.2972,616,070 - 72,694,553 (-)NCBI
RefSeq Acc Id: XM_039084174   ⟹   XP_038940102
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
mRatBN7.2972,616,070 - 72,694,552 (-)NCBI
RefSeq Acc Id: XM_039084175   ⟹   XP_038940103
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
mRatBN7.2972,616,070 - 72,694,550 (-)NCBI
RefSeq Acc Id: XM_039084176   ⟹   XP_038940104
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
mRatBN7.2972,616,070 - 72,694,105 (-)NCBI
RefSeq Acc Id: XM_063267688   ⟹   XP_063123758
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,069,966 - 80,144,167 (-)NCBI
RefSeq Acc Id: XM_063267689   ⟹   XP_063123759
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8980,096,410 - 80,144,167 (-)NCBI
1 to 5 of 12 rows
1 to 5 of 12 rows
RefSeq Acc Id: NP_072144   ⟸   NM_022622
- UniProtKB: Q9QZH2 (UniProtKB/Swiss-Prot),   A0A0G2K9Y6 (UniProtKB/TrEMBL),   A6KFF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075183   ⟸   ENSRNOT00000087870
Ensembl Acc Id: ENSRNOP00000020414   ⟸   ENSRNOT00000020414
RefSeq Acc Id: XP_038940101   ⟸   XM_039084173
- Peptide Label: isoform X1
- UniProtKB: Q9QZH2 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_038940102   ⟸   XM_039084174
- Peptide Label: isoform X2
- UniProtKB: Q9QZH2 (UniProtKB/Swiss-Prot),   A0A8I6A6U6 (UniProtKB/TrEMBL)
BRCT   RING-type

Name Modeler Protein Id AA Range Protein Structure
AF-Q9QZH2-F1-model_v2 AlphaFold Q9QZH2 1-768 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 44 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27255 BioCyc
Ensembl Genes ENSRNOG00000014960 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000020414 ENTREZGENE
  ENSRNOT00000087870 ENTREZGENE
  ENSRNOT00000119929 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  3.30.40.10 UniProtKB/Swiss-Prot
  3.40.50.10190 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  BARD1_Znf-RING UniProtKB/Swiss-Prot
  BRCT_dom UniProtKB/Swiss-Prot
  BRCT_dom_sf UniProtKB/Swiss-Prot
  Znf_RING UniProtKB/Swiss-Prot
  Znf_RING/FYVE/PHD UniProtKB/Swiss-Prot
  Znf_RING_CS UniProtKB/Swiss-Prot
KEGG Report rno:64557 UniProtKB/Swiss-Prot
NCBI Gene 64557 ENTREZGENE
PANTHER ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED UniProtKB/Swiss-Prot
  BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  zf-RING_6 UniProtKB/Swiss-Prot
PhenoGen Bard1 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  BRCT UniProtKB/Swiss-Prot
  ZF_RING_1 UniProtKB/Swiss-Prot
  ZF_RING_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014960 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  BRCT UniProtKB/Swiss-Prot
Superfamily-SCOP RING/U-box UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
  SSF52113 UniProtKB/Swiss-Prot
UniProt A0A0G2K9Y6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNM7_RAT UniProtKB/TrEMBL
  A0A8I6A6U6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6ATK8_RAT UniProtKB/TrEMBL
  A6KFF8 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 44 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Bard1  BRCA1 associated RING domain 1    BRCA1-associated RING domain protein 1  Name updated 1299863 APPROVED
2002-08-07 Bard1  BRCA1-associated RING domain protein 1      Symbol and Name status set to provisional 70820 PROVISIONAL