Pik3r3 (phosphoinositide-3-kinase regulatory subunit 3) - Rat Genome Database

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Gene: Pik3r3 (phosphoinositide-3-kinase regulatory subunit 3) Rattus norvegicus
Analyze
Symbol: Pik3r3
Name: phosphoinositide-3-kinase regulatory subunit 3
RGD ID: 621042
Description: Enables 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in several processes, including cell migration involved in sprouting angiogenesis; insulin receptor signaling pathway; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be part of phosphatidylinositol 3-kinase complex, class IA. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in colon adenocarcinoma. Orthologous to human PIK3R3 (phosphoinositide-3-kinase regulatory subunit 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: p55PIK; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3; phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55); phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma; phosphatidylinositol 3-kinase p55 subunit; phosphatidylinositol 3-kinase regulatory subunit gamma; phosphoinositide-3-kinase, regulatory subunit 3 (gamma); PI3-kinase p85 subunit gamma; PI3-kinase regulatory subunit gamma; PI3-kinase subunit p55-gamma; PI3K regulatory subunit gamma; ptdIns-3-kinase p85-gamma; ptdIns-3-kinase regulatory subunit gamma; ptdIns-3-kinase regulatory subunit p55-gamma
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,936,790 - 135,009,303 (+)NCBIGRCr8
mRatBN7.25129,700,925 - 129,772,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,701,229 - 129,772,583 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,318,324 - 132,396,864 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,072,913 - 134,151,457 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,095,352 - 134,173,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,069,972 - 135,145,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,074,297 - 135,142,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,858,124 - 138,930,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,497,494 - 136,566,473 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,502,719 - 136,571,699 (+)NCBI
Celera5128,230,224 - 128,297,191 (+)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3r3Ratcolon adenocarcinoma treatmentISOPIK3R3 (Homo sapiens)13432053 RGD 
Pik3r3RatColorectal Neoplasms  ISOPIK3R3 (Homo sapiens)13432046 RGD 
Pik3r3Rathepatocellular carcinoma treatmentIEP 152177911 RGD 
Pik3r3Rathigh grade glioma treatmentISOPIK3R3 (Homo sapiens)13782053 RGD 
Pik3r3RatNeoplasm Metastasis  ISOPIK3R3 (Homo sapiens)13432045associated with Adenocarcinoma and ColonRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3r3RatBreast Cancer, Familial  ISOPIK3R3 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial cancer of breastClinVarPMID:25741868
Pik3r3RatCharcot-Marie-Tooth disease dominant intermediate C  ISOPIK3R3 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532
Pik3r3Ratdevelopmental and epileptic encephalopathy  ISOPIK3R3 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
Pik3r3Ratearly infantile epileptic encephalopathy  ISOPIK3R3 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532

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Object Symbol
Species
Term
Qualifier
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With
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Notes
Source
Original Reference(s)
Pik3r3Rat1,1-dichloroethene decreases expressionISOPik3r3 (Mus musculus)6480464vinylidene chloride results in decreased expression of PIK3R3 mRNACTDPMID:26682919
Pik3r3Rat1,2-dimethylhydrazine decreases expressionISOPik3r3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of PIK3R3 mRNACTDPMID:22206623
Pik3r3Rat17beta-estradiol multiple interactionsISOPIK3R3 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PIK3R3 mRNA and [Estradiol co-treated with TGFB1 protein] results in decreased expression of PIK3R3 mRNACTDPMID:19619570 and PMID:30165855
Pik3r3Rat17beta-estradiol increases expressionISOPik3r3 (Mus musculus)6480464Estradiol results in increased expression of PIK3R3 mRNACTDPMID:39298647
Pik3r3Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of PIK3R3 mRNACTDPMID:26496021
Pik3r3Rat17beta-estradiol decreases expressionISOPIK3R3 (Homo sapiens)6480464Estradiol results in decreased expression of PIK3R3 mRNACTDPMID:26865669
Pik3r3Rat17beta-estradiol increases expressionISOPIK3R3 (Homo sapiens)6480464Estradiol results in increased expression of PIK3R3 mRNACTDPMID:19619570
Pik3r3Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOPik3r3 (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
Pik3r3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPIK3R3 (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in increased expression of PIK3R3 mRNACTDPMID:19619570
Pik3r3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PIK3R3 mRNACTDPMID:33387578
Pik3r3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PIK3R3 mRNACTDPMID:27913140 and PMID:32109520
Pik3r3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPik3r3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PIK3R3 mRNACTDPMID:19770486 more ...
Pik3r3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPik3r3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PIK3R3 mRNACTDPMID:21570461 and PMID:26377647
Pik3r3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPik3r3 (Mus musculus)6480464[TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of PIK3R3 mRNACTDPMID:25975270
Pik3r3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPIK3R3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of PIK3R3 mRNACTDPMID:19619570
Pik3r3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPik3r3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of PIK3R3 mRNACTDPMID:20159946
Pik3r3Rat3,3',4,4',5-pentachlorobiphenyl increases expressionEXP 64804643 more ...CTDPMID:23196670
Pik3r3Rat3,3',5,5'-tetrabromobisphenol A decreases expressionISOPik3r3 (Mus musculus)6480464tetrabromobisphenol A results in decreased expression of PIK3R3 mRNACTDPMID:25172293
Pik3r3Rat4,4'-sulfonyldiphenol increases expressionISOPIK3R3 (Homo sapiens)6480464bisphenol S results in increased expression of PIK3R3 mRNACTDPMID:27685785
Pik3r3Rat4-hydroxyphenyl retinamide increases expressionISOPik3r3 (Mus musculus)6480464Fenretinide results in increased expression of PIK3R3 mRNACTDPMID:28973697

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Biological Process

  

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3r3Ratphosphatidylinositol 3-kinase complex part_ofISOPik3r3 (Mus musculus)1624291PR:P42337 PMID:7542745RGDPMID:7542745
Pik3r3Ratphosphatidylinositol 3-kinase complex, class IA part_ofIBAFB:FBgn0020622 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function

  

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3r3Ratphosphatidylinositol 3-kinase-Akt signaling pathway   ISOPIK3R3 (Homo sapiens)2290458 RGD 

Imported Annotations - KEGG (archival)

1 to 20 of 34 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Pik3r3Ratacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221
Pik3r3Rataldosterone signaling pathway   IEA 6907045 KEGGrno:04960
Pik3r3Ratapoptotic cell death pathway  IEA 6907045 KEGGrno:04210
Pik3r3RatB cell receptor signaling pathway  IEA 6907045 KEGGrno:04662
Pik3r3Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Pik3r3RatChagas disease pathway  IEA 6907045 KEGGrno:05142
Pik3r3Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Pik3r3Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Pik3r3Ratcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
Pik3r3Ratendometrial cancer pathway   IEA 6907045 KEGGrno:05213
Pik3r3RatEntamoebiasis pathway  IEA 6907045 KEGGrno:05146
Pik3r3Ratepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
Pik3r3RatFc epsilon receptor mediated signaling pathway  IEA 6907045 KEGGrno:04664
Pik3r3RatFc gamma receptor mediated signaling pathway  IEA 6907045 KEGGrno:04666
Pik3r3Ratglioma pathway  IEA 6907045 KEGGrno:05214
Pik3r3Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Pik3r3Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Pik3r3Ratinsulin signaling pathway   IEA 6907045 KEGGrno:04910
Pik3r3RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Pik3r3Ratmeasles pathway  IEA 6907045 KEGGrno:05162
1 to 20 of 34 rows

Imported Annotations - PID (archival)


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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Phosphoinositide 3-kinases as a common platform for multi-hormone signaling. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
4. A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK Is generated by alternative splicing of the p85alpha gene. Inukai K, etal., J Biol Chem 1996 Mar 8;271(10):5317-20.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Analysis of expression profile of gene encoding proteins of signal cascades activated by insulin-like growth factors in colorectal cancer. Nowakowska-Zajdel E, etal., Int J Immunopathol Pharmacol. 2011 Jul-Sep;24(3):781-7.
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. PIK3R3 induces epithelial-to-mesenchymal transition and promotes metastasis in colorectal cancer. Wang G, etal., Mol Cancer Ther. 2014 Jul;13(7):1837-47. doi: 10.1158/1535-7163.MCT-14-0049. Epub 2014 May 16.
14. Altered p53 regulation of miR-148b and p55PIK contributes to tumor progression in colorectal cancer. Wang G, etal., Oncogene. 2015 Feb 12;34(7):912-21. doi: 10.1038/onc.2014.30. Epub 2014 Mar 17.
15. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
16. MicroRNA-365 inhibits proliferation, migration and invasion of glioma by targeting PIK3R3. Zhu Y, etal., Oncol Rep. 2017 Apr;37(4):2185-2192. doi: 10.3892/or.2017.5458. Epub 2017 Feb 16.
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PMID:7542745   PMID:20624904   PMID:25388664   PMID:28341552  



Pik3r3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85134,936,790 - 135,009,303 (+)NCBIGRCr8
mRatBN7.25129,700,925 - 129,772,591 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5129,701,229 - 129,772,583 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,318,324 - 132,396,864 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,072,913 - 134,151,457 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,095,352 - 134,173,900 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,069,972 - 135,145,633 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,074,297 - 135,142,488 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05138,858,124 - 138,930,177 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,497,494 - 136,566,473 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,502,719 - 136,571,699 (+)NCBI
Celera5128,230,224 - 128,297,191 (+)NCBICelera
Cytogenetic Map5q35NCBI
PIK3R3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38146,040,140 - 46,174,901 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl146,040,140 - 46,133,036 (-)EnsemblGRCh38hg38GRCh38
GRCh37146,505,812 - 46,640,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36146,278,399 - 46,370,901 (-)NCBINCBI36Build 36hg18NCBI36
Build 34146,217,832 - 46,310,334NCBI
Celera144,793,099 - 44,886,009 (-)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,620,825 - 44,713,687 (-)NCBIHuRef
CHM1_1146,622,976 - 46,715,844 (-)NCBICHM1_1
T2T-CHM13v2.0145,917,331 - 46,052,095 (-)NCBIT2T-CHM13v2.0
Pik3r3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,078,593 - 116,160,253 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,030,581 - 116,157,038 (+)EnsemblGRCm39 Ensembl
GRCm39 Ensembl4116,078,815 - 116,160,253 (+)EnsemblGRCm39 Ensembl
GRCm384116,221,400 - 116,303,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,173,384 - 116,299,841 (+)EnsemblGRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,221,618 - 116,303,056 (+)EnsemblGRCm38mm10GRCm38
MGSCv374115,894,519 - 115,975,661 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364115,719,846 - 115,800,988 (+)NCBIMGSCv36mm8
Celera4114,959,917 - 115,043,525 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.1NCBI
PIK3R3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21180,672,682 - 180,765,512 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11179,814,236 - 179,907,088 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0145,345,946 - 45,481,031 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,700,153 - 46,835,812 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,700,153 - 46,792,920 (-)Ensemblpanpan1.1panPan2
LOC100856339
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,222,059 - 14,357,200 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,235,824 - 14,353,832 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,339,320 - 14,478,832 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,369,954 - 14,509,881 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,387,484 - 14,509,849 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,170,772 - 14,310,183 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,239,288 - 14,378,669 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,308,726 - 14,448,356 (+)NCBIUU_Cfam_GSD_1.0
Pik3r3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505861,270,346 - 61,346,909 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647427,095,100 - 27,171,252 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647427,095,125 - 27,171,416 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100511937
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,268,568 - 165,402,649 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,268,260 - 165,402,668 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26152,797,396 - 152,914,712 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3R3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12086,651,692 - 86,748,670 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2086,651,520 - 86,745,116 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603330,235,811 - 30,332,860 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

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Variants in Pik3r3
239 total Variants

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:128
Interacting mature miRNAs:135
Transcripts:ENSRNOT00000000157
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat

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D5Rat201  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,712,378 - 129,712,586 (+)MAPPERmRatBN7.2
Rnor_6.05135,085,475 - 135,085,682NCBIRnor6.0
Rnor_5.05138,869,546 - 138,869,753UniSTSRnor5.0
RGSC_v3.45136,507,976 - 136,508,184RGDRGSC3.4
RGSC_v3.45136,507,977 - 136,508,184UniSTSRGSC3.4
RGSC_v3.15136,513,195 - 136,513,538RGD
Celera5128,240,707 - 128,240,922UniSTS
SHRSP x BN Map568.3499RGD
SHRSP x BN Map568.3499UniSTS
Cytogenetic Map5q36UniSTS
RH144265  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25129,700,290 - 129,700,414 (+)MAPPERmRatBN7.2
Rnor_6.05135,073,388 - 135,073,511NCBIRnor6.0
Rnor_5.05138,857,423 - 138,857,546UniSTSRnor5.0
RGSC_v3.45136,495,889 - 136,496,012UniSTSRGSC3.4
Celera5128,228,619 - 128,228,742UniSTS
RH 3.4 Map5837.8UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 17 of 17 rows
RefSeq Transcripts NM_001429916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429919 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_022213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006238714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017593605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039110699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D64047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000005 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000000157   ⟹   ENSRNOP00000000157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5129,701,229 - 129,772,583 (+)Ensembl
Rnor_6.0 Ensembl5135,074,297 - 135,142,488 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000096934   ⟹   ENSRNOP00000088375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5129,701,229 - 129,772,583 (+)Ensembl
RefSeq Acc Id: NM_022213   ⟹   NP_071549
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,938,606 - 135,009,303 (+)NCBI
mRatBN7.25129,701,892 - 129,772,591 (+)NCBI
Rnor_6.05135,074,993 - 135,142,291 (+)NCBI
Rnor_5.05138,858,124 - 138,930,177 (+)NCBI
RGSC_v3.45136,497,494 - 136,566,473 (+)RGD
Celera5128,230,224 - 128,297,191 (+)RGD
Sequence:
RefSeq Acc Id: XM_006238714   ⟹   XP_006238776
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,937,723 - 135,009,303 (+)NCBI
mRatBN7.25129,701,061 - 129,772,591 (+)NCBI
Rnor_6.05135,074,158 - 135,145,633 (+)NCBI
Rnor_5.05138,858,124 - 138,930,177 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039110698   ⟹   XP_038966626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,937,799 - 135,009,303 (+)NCBI
mRatBN7.25129,701,199 - 129,772,591 (+)NCBI
RefSeq Acc Id: XM_039110699   ⟹   XP_038966627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85134,936,790 - 135,009,303 (+)NCBI
mRatBN7.25129,700,925 - 129,772,591 (+)NCBI
RefSeq Acc Id: NP_071549   ⟸   NM_022213
- UniProtKB: Q63789 (UniProtKB/Swiss-Prot),   G3V605 (UniProtKB/TrEMBL),   A6JZ71 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006238776   ⟸   XM_006238714
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000000157   ⟸   ENSRNOT00000000157
RefSeq Acc Id: XP_038966627   ⟸   XM_039110699
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038966626   ⟸   XM_039110698
- Peptide Label: isoform X1
SH2

Name Modeler Protein Id AA Range Protein Structure
AF-Q63789-F1-model_v2 AlphaFold Q63789 1-461 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693933
Promoter ID:EPDNEW_R4458
Type:multiple initiation site
Name:Pik3r3_1
Description:phosphoinositide-3-kinase regulatory subunit 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05135,074,325 - 135,074,385EPDNEW


1 to 29 of 29 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40257 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000000145 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000157 ENTREZGENE
Gene3D-CATH 1.10.287.1490 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
InterPro PI3K_P85_iSH2 UniProtKB/Swiss-Prot
  PI3kinase_P85_cSH2 UniProtKB/Swiss-Prot
  PI3kinase_P85_nSH2 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:60664 UniProtKB/Swiss-Prot
NCBI Gene 60664 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA UniProtKB/Swiss-Prot
Pfam PI3K_P85_iSH2 UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
PhenoGen Pik3r3 PhenoGen
PRINTS PI3KINASEP85 UniProtKB/Swiss-Prot
  SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000145 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF55550 UniProtKB/Swiss-Prot
UniProt A0A8I6A9P1_RAT UniProtKB/TrEMBL
  A6JZ71 ENTREZGENE, UniProtKB/TrEMBL
  G3V605 ENTREZGENE, UniProtKB/TrEMBL
  P55G_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 29 of 29 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-30 Pik3r3  phosphoinositide-3-kinase regulatory subunit 3  Pik3r3  phosphoinositide-3-kinase, regulatory subunit 3 (gamma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pik3r3  phosphoinositide-3-kinase, regulatory subunit 3 (gamma)  Pik3r3  phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Pik3r3  phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3 (p55)  Pik3r3  phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Pik3r3  phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 3    phosphatidylinositol 3-kinase p55 subunit  Name updated 1299863 APPROVED
2002-08-07 Pik3r3  phosphatidylinositol 3-kinase p55 subunit      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression ubiquitously expressed; enriched in brain 68289