Pik3c3 (phosphatidylinositol 3-kinase, catalytic subunit type 3) - Rat Genome Database

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Gene: Pik3c3 (phosphatidylinositol 3-kinase, catalytic subunit type 3) Rattus norvegicus
Analyze
Symbol: Pik3c3
Name: phosphatidylinositol 3-kinase, catalytic subunit type 3
RGD ID: 620899
Description: Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including autophagosome assembly; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and response to L-leucine. Predicted to be located in several cellular components, including autolysosome; cytoplasmic vesicle; and midbody. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including GABA-ergic synapse; endosome; and glutamatergic synapse. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3); PARTICIPATES IN phosphatidylinositol 3-kinase signaling pathway; autophagy pathway; inositol metabolic pathway; INTERACTS WITH (R)-noradrenaline; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: catalytic phosphatidylinositol 3-kinase 3; phosphatidylinositol 3-kinase; phosphatidylinositol 3-kinase catalytic subunit type 3; phosphoinositide-3-kinase, class 3; PI-3K Vps34p; PI3-kinase type 3; PI3K type 3; ptdIns-3-kinase type 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81822,119,677 - 22,203,546 (+)NCBIGRCr8
mRatBN7.21821,845,282 - 21,934,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1821,845,295 - 21,929,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1821,980,005 - 22,057,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01822,758,425 - 22,836,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01822,068,675 - 22,152,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01822,964,121 - 23,047,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01822,694,862 - 22,778,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41822,495,197 - 22,579,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11822,521,842 - 22,606,301 (+)NCBI
Celera1821,624,416 - 21,707,267 (+)NCBICelera
Cytogenetic Map18p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Pik3c3Ratchromosome 18q deletion syndrome  ISOPIK3C3 (Homo sapiens)8554872ClinVar Annotator: match by term: Monosomy 18q and deletion 18qClinVarPMID:31690835
Pik3c3Ratintellectual disability  ISOPIK3C3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 

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Original Reference(s)
Pik3c3Rat(1->4)-beta-D-glucan multiple interactionsISOPik3c3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of PIK3C3 mRNACTDPMID:36331819
Pik3c3Rat(R)-noradrenaline increases expressionEXP 6480464Norepinephrine results in increased expression of PIK3C3 mRNACTDPMID:14618266
Pik3c3Rat1,2-dichloroethane decreases expressionISOPik3c3 (Mus musculus)6480464ethylene dichloride results in decreased expression of PIK3C3 mRNACTDPMID:28960355
Pik3c3Rat17beta-estradiol decreases expressionISOPik3c3 (Mus musculus)6480464Estradiol results in decreased expression of PIK3C3 mRNACTDPMID:39298647
Pik3c3Rat2,3',4,4',5-Pentachlorobiphenyl increases phosphorylationEXP 64804642 more ...CTDPMID:31020377
Pik3c3Rat2,3',4,4',5-Pentachlorobiphenyl decreases expressionEXP 64804642 more ...CTDPMID:31020377
Pik3c3Rat2,3',4,4',5-Pentachlorobiphenyl multiple interactionsEXP 6480464DAPK2 protein affects the reaction [2 more ...CTDPMID:31020377
Pik3c3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPIK3C3 (Homo sapiens)6480464Cycloheximide inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3C3 mRNA]CTDPMID:11007951
Pik3c3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPik3c3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PIK3C3 mRNACTDPMID:21570461
Pik3c3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of PIK3C3 mRNA]CTDPMID:21215274
Pik3c3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PIK3C3 mRNACTDPMID:21215274
Pik3c3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOPIK3C3 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of PIK3C3 mRNACTDPMID:11007951
Pik3c3Rat2-hydroxypropanoic acid decreases expressionISOPIK3C3 (Homo sapiens)6480464Lactic Acid results in decreased expression of PIK3C3 mRNACTDPMID:30851411
Pik3c3Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOPIK3C3 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PIK3C3 mRNA and [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PIK3C3 mRNACTDPMID:28628672
Pik3c3Rat3-methyladenine multiple interactionsISOPIK3C3 (Homo sapiens)64804643-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein more ...CTDPMID:20525898 more ...
Pik3c3Rat3-methyladenine multiple interactionsEXP 64804643-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]] and 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of PIK3C3 protein]CTDPMID:35066094
Pik3c3Rat3H-1,2-dithiole-3-thione decreases expressionEXP 64804641 and 2-dithiol-3-thione results in decreased expression of PIK3C3 mRNACTDPMID:19162173
Pik3c3Rat4,4'-sulfonyldiphenol multiple interactionsISOPIK3C3 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of PIK3C3 mRNACTDPMID:28628672
Pik3c3Rat4,4'-sulfonyldiphenol decreases expressionISOPik3c3 (Mus musculus)6480464bisphenol S results in decreased expression of PIK3C3 mRNACTDPMID:39298647
Pik3c3RatABT-737 multiple interactionsISOPIK3C3 (Homo sapiens)6480464PIK3C3 mutant form promotes the reaction [[Celecoxib co-treated with ABT-737] results in increased cleavage of CASP3 protein] more ...CTDPMID:20104024

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Biological Process
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Original Reference(s)
Pik3c3Ratautophagosome assembly  IMP 2303129 RGD 
Pik3c3Ratautophagosome assembly involved_inIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratautophagosome assembly acts_upstream_of_or_withinISOPik3c3 (Mus musculus)1624291 PMID:24098492RGDPMID:24098492
Pik3c3Ratautophagosome assembly involved_inIBAMGI:2445019 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c3Ratautophagosome assembly involved_inISOPIK3C3 (Homo sapiens)1624291 PMID:33637724RGDPMID:33637724
Pik3c3Ratautophagosome assembly acts_upstream_of_or_withinIEAUniProtKB:Q6PF93 and ensembl:ENSMUSP000001114791600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratautophagosome maturation involved_inIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratautophagosome maturation involved_inISOPIK3C3 (Homo sapiens)1624291 PMID:10625637RGDPMID:10625637
Pik3c3Ratautophagy acts_upstream_of_or_withinISOPIK3C3 (Homo sapiens)1624291 PMID:25327288RGDPMID:25327288
Pik3c3Ratautophagy involved_inIEAUniProtKB-KW:KW-00721600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c3Ratautophagy acts_upstream_of_or_withinIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c3Ratcellular response to glucose starvation involved_inISSUniProtKB:Q6PF931600115GO_REF:0000024UniProtGO_REF:0000024
Pik3c3Ratcellular response to glucose starvation involved_inISOPik3c3 (Mus musculus)1624291 PMID:23332761RGDPMID:23332761
Pik3c3Ratcellular response to glucose starvation involved_inIEAUniProtKB:Q6PF93 and ensembl:ENSMUSP000001114791600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratcellular response to starvation acts_upstream_of_or_withinISOPik3c3 (Mus musculus)1624291 PMID:24098492RGDPMID:24098492
Pik3c3Ratcellular response to starvation acts_upstream_of_or_withinIEAUniProtKB:Q6PF93 and ensembl:ENSMUSP000001114791600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratearly endosome to late endosome transport involved_inISSUniProtKB:Q8NEB91600115GO_REF:0000024UniProtGO_REF:0000024
Pik3c3Ratearly endosome to late endosome transport involved_inISOPIK3C3 (Homo sapiens)1624291 PMID:14617358RGDPMID:14617358
Pik3c3Ratearly endosome to late endosome transport involved_inIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Pik3c3Ratautolysosome located_inISOPIK3C3 (Homo sapiens)1624291 PMID:25327288RGDPMID:25327288
Pik3c3Ratautolysosome located_inIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratautophagosome located_inIEAUniProtKB-SubCell:SL-00231600115GO_REF:0000044UniProtGO_REF:0000044
Pik3c3Rataxoneme located_inISSUniProtKB:Q6PF931600115GO_REF:0000024UniProtGO_REF:0000024
Pik3c3Ratcytoplasm is_active_inIBAFB:FBgn0004373 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c3Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c3Ratendosome is_active_inIBAFB:FBgn0015277 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c3Ratendosome located_inIEAUniProtKB-KW:KW-09671600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c3RatGABA-ergic synapse is_active_inISOPik3c3 (Mus musculus)1624291 PMID:35318705RGDPMID:35318705
Pik3c3RatGABA-ergic synapse is_active_inIEAUniProtKB:Q6PF93 and ensembl:ENSMUSP000001114791600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratglutamatergic synapse is_active_inISOPik3c3 (Mus musculus)1624291 PMID:35318705RGDPMID:35318705
Pik3c3Ratglutamatergic synapse is_active_inIEAUniProtKB:Q6PF93 and ensembl:ENSMUSP000001114791600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratlate endosome located_inISSUniProtKB:Q8NEB91600115GO_REF:0000024UniProtGO_REF:0000024
Pik3c3Ratlate endosome located_inIEAUniProtKB-SubCell:SL-01521600115GO_REF:0000044UniProtGO_REF:0000044
Pik3c3Ratlate endosome located_inISOPIK3C3 (Homo sapiens)1624291 PMID:14617358RGDPMID:14617358
Pik3c3Ratlate endosome located_inIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratmembrane is_active_inIBACGD:CAL0000198621 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c3Ratmidbody located_inIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratmidbody located_inIEAUniProtKB-SubCell:SL-04691600115GO_REF:0000044UniProtGO_REF:0000044
Pik3c3Ratmidbody located_inISOPIK3C3 (Homo sapiens)1624291 PMID:20208530RGDPMID:20208530
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Molecular Function
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Original Reference(s)
Pik3c3Rat1-phosphatidylinositol-3-kinase activity  IDA 633560 RGD 
Pik3c3Rat1-phosphatidylinositol-3-kinase activity enablesIEARHEA:127091600115GO_REF:0000116RHEAGO_REF:0000116
Pik3c3Rat1-phosphatidylinositol-3-kinase activity enablesIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Rat1-phosphatidylinositol-3-kinase activity enablesIEAEC:2.7.1.1371600115GO_REF:0000003UniProtGO_REF:0000003
Pik3c3Rat1-phosphatidylinositol-3-kinase activity enablesIBACGD:CAL0000195103 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c3Rat1-phosphatidylinositol-3-kinase activity enablesIEAInterPro:IPR0082901600115GO_REF:0000002InterProGO_REF:0000002
Pik3c3Rat1-phosphatidylinositol-3-kinase activity enablesISOPIK3C3 (Homo sapiens)1624291 PMID:20208530 more ...RGDPMID:20208530 more ...
Pik3c3Rat1-phosphatidylinositol-3-kinase activity enablesIEAUniRule:UR0001145061600115GO_REF:0000104UniProtGO_REF:0000104
Pik3c3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c3RatATP binding enablesIEAUniRule:UR0001145061600115GO_REF:0000104UniProtGO_REF:0000104
Pik3c3Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c3Ratkinase activity enablesIEAInterPro:IPR0189361600115GO_REF:0000002InterProGO_REF:0000002
Pik3c3Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c3Ratphosphatidylinositol kinase activity enablesIEAARBA:ARBA000334941600115GO_REF:0000117UniProtGO_REF:0000117
Pik3c3Ratphosphatidylinositol kinase activity enablesIEAUniProtKB:Q8NEB9 and ensembl:ENSP000002620391600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratphosphatidylinositol kinase activity enablesISOPIK3C3 (Homo sapiens)1624291 PMID:7628435RGDPMID:7628435
Pik3c3Ratprotein binding enablesISOPIK3C3 (Homo sapiens)1624291UniProtKB:A8MW95 more ...RGDPMID:14617358 more ...
Pik3c3Ratprotein binding enablesISOPik3c3 (Mus musculus)1624291PR:O88597 more ...RGDPMID:22493499 more ...
Pik3c3Ratprotein kinase activity enablesIEAUniProtKB:Q6PF93 and ensembl:ENSMUSP000001114791600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c3Ratprotein kinase activity enablesISOPik3c3 (Mus musculus)1624291 PMID:15010863RGDPMID:15010863
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RGD Manual Annotations


  
Object Symbol
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Reference
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Source
Original Reference(s)
Pik3c3Ratautophagy pathway   ISOPIK3C3 (Homo sapiens)4889529 RGD 
Pik3c3Ratphosphatidylinositol 3-kinase signaling pathway  IMP 633560 RGD 

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Pik3c3Ratinositol metabolic pathway  ISOPIK3C3 (Homo sapiens)10402751 SMPDBSMP:00011
Pik3c3Ratphosphoinositide metabolic pathway  ISOPIK3C3 (Homo sapiens)10402751 SMPDBSMP:00463

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Source
Original Reference(s)
Pik3c3Ratautophagy pathway   IEA 6907045 KEGGrno:04140
Pik3c3Ratinositol phosphate metabolic pathway  IEA 6907045 KEGGrno:00562
Pik3c3Ratphagocytosis pathway  IEA 6907045 KEGGrno:04145
Pik3c3Ratphosphatidylinositol 3-kinase signaling pathway  IEA 6907045 KEGGrno:04070
Pik3c3Rattuberculosis pathway  IEA 6907045 KEGGrno:05152

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#
Reference Title
Reference Citation
1. Two modes of secretion in pancreatic acinar cells: involvement of phosphatidylinositol 3-kinase and regulation by capacitative Ca(2+) entry. Campos-Toimil M, etal., Curr Biol 2002 Feb 5;12(3):211-5.
2. Phosphoinositol 3 kinase inhibitor, LY294002 increases bcl-2 protein and inhibits okadaic acid-induced apoptosis in Bcl-2 expressing renal epithelial cells. Carbott DE, etal., Apoptosis 2002 Feb;7(1):69-76.
3. Inhibition of autophagy in mitotic animal cells. Eskelinen EL, etal., Traffic. 2002 Dec;3(12):878-93.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines. Haller D, etal., J Biol Chem 2002 Oct 11;277(41):38168-78.
6. Differential PI 3-kinase dependence of early and late phases of recycling of the internalized AT1 angiotensin receptor. Hunyady L, etal., J Cell Biol 2002 Jun 24;157(7):1211-22.
7. Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration. Irani C, etal., Am J Physiol Lung Cell Mol Physiol 2002 Apr;282(4):L854-62.
8. Requirement of phosphatidylinositol 3-kinase activation and calcium influx for leukotriene B4-induced enzyme release. Ito N, etal., J Biol Chem 2002 Nov 22;277(47):44898-904.
9. The phosphatidylinositol 3-kinase/Akt signaling pathway modulates the endocrine differentiation of trophoblast cells. Kamei T, etal., Mol Endocrinol 2002 Jul;16(7):1469-81.
10. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
11. mVps34 is activated following high-resistance contractions. MacKenzie MG, etal., J Physiol. 2009 Jan 15;587(Pt 1):253-60. Epub 2008 Nov 17.
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Comprehensive gene review and curation RGD comprehensive gene curation
20. Overexpression of a rat kinase-deficient phosphoinositide 3-kinase, Vps34p, inhibits cathepsin D maturation. Row PE, etal., Biochem J 2001 Feb 1;353(Pt 3):655-61.
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PMID:12198247   PMID:12242025   PMID:12373512   PMID:12444071   PMID:12540590   PMID:12581861   PMID:12610654   PMID:12624428   PMID:12683952   PMID:12730091   PMID:12754199   PMID:12761242  
PMID:12766174   PMID:12789537   PMID:12816756   PMID:12829832   PMID:12876381   PMID:12880866   PMID:14563664   PMID:14578357   PMID:14617358   PMID:14645111   PMID:14670845   PMID:14742297  
PMID:14993194   PMID:14993225   PMID:14999001   PMID:15006556   PMID:15010863   PMID:15385613   PMID:15489334   PMID:15613677   PMID:15701816   PMID:15880264   PMID:15964902   PMID:16046456  
PMID:16095815   PMID:16533525   PMID:16648180   PMID:16682826   PMID:17241518   PMID:17393104   PMID:17437535   PMID:18040895   PMID:18716370   PMID:18777595   PMID:19946888   PMID:20208530  
PMID:20643123   PMID:22098068   PMID:22493499   PMID:23332761   PMID:24098492   PMID:25046113   PMID:25327288   PMID:25578879   PMID:27021411  



Pik3c3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81822,119,677 - 22,203,546 (+)NCBIGRCr8
mRatBN7.21821,845,282 - 21,934,387 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1821,845,295 - 21,929,048 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1821,980,005 - 22,057,408 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01822,758,425 - 22,836,045 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01822,068,675 - 22,152,371 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01822,964,121 - 23,047,896 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01822,694,862 - 22,778,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41822,495,197 - 22,579,656 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11822,521,842 - 22,606,301 (+)NCBI
Celera1821,624,416 - 21,707,267 (+)NCBICelera
Cytogenetic Map18p12NCBI
PIK3C3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381841,955,234 - 42,087,830 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1841,955,234 - 42,087,830 (+)EnsemblGRCh38hg38GRCh38
GRCh371839,535,199 - 39,667,794 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361837,789,197 - 37,915,446 (+)NCBINCBI36Build 36hg18NCBI36
Build 341837,789,196 - 37,915,442NCBI
Celera1836,343,751 - 36,469,999 (+)NCBICelera
Cytogenetic Map18q12.3NCBI
HuRef1836,394,067 - 36,520,574 (+)NCBIHuRef
CHM1_11839,462,215 - 39,588,448 (+)NCBICHM1_1
T2T-CHM13v2.01842,146,975 - 42,279,510 (+)NCBIT2T-CHM13v2.0
Pik3c3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391830,390,441 - 30,481,179 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1830,405,800 - 30,481,179 (+)EnsemblGRCm39 Ensembl
GRCm381830,265,615 - 30,348,126 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1830,272,747 - 30,348,126 (+)EnsemblGRCm38mm10GRCm38
MGSCv371830,432,550 - 30,507,774 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361830,415,906 - 30,491,130 (+)NCBIMGSCv36mm8
Celera1830,744,294 - 30,819,480 (+)NCBICelera
Cytogenetic Map18B1NCBI
cM Map1817.41NCBI
Pik3c3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540228,081,098 - 28,196,252 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540228,081,150 - 28,195,305 (+)NCBIChiLan1.0ChiLan1.0
PIK3C3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21759,346,533 - 59,473,026 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11845,039,112 - 45,168,822 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01835,203,896 - 35,336,512 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11838,754,789 - 38,882,042 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1838,754,789 - 38,882,037 (+)Ensemblpanpan1.1panPan2
PIK3C3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1748,663,381 - 48,800,350 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl748,663,381 - 48,800,437 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha748,073,292 - 48,210,175 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0748,617,615 - 48,754,695 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl748,614,671 - 48,754,703 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1748,315,599 - 48,452,309 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0748,357,572 - 48,494,156 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0748,638,915 - 48,775,800 (-)NCBIUU_Cfam_GSD_1.0
Pik3c3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494444,700,595 - 44,818,119 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365174,033,247 - 4,145,422 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365174,009,938 - 4,145,518 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3C3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6125,890,712 - 126,043,157 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16125,890,598 - 126,038,753 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26117,947,967 - 118,097,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3C3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11838,785,476 - 38,914,279 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1838,787,717 - 38,914,185 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605013,268,474 - 13,404,235 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3c3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477916,307,800 - 16,434,169 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477916,307,875 - 16,435,567 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pik3c3
722 total Variants

Predicted Target Of
Summary Value
Count of predictions:159
Count of miRNA genes:131
Interacting mature miRNAs:140
Transcripts:ENSRNOT00000066816
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 34 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2301410Bp317Blood pressure QTL 3170.004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)181194427326548295Rat
1358358Sradr6Stress Responsive Adrenal Weight QTL 62.49adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)181194429959330563Rat
1331735Rf44Renal function QTL 442.981urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)181823456431359530Rat
61382Bp46Blood pressure QTL 4618.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194179131393320Rat
1331741Bp232Blood pressure QTL 2323.59112arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)182137289383213037Rat
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
1331781Scl28Serum cholesterol level QTL 283.995blood HDL cholesterol amount (VT:0000184)serum high density lipoprotein cholesterol level (CMO:0000361)181194429924797117Rat
6903359Bp355Blood pressure QTL 3553.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)181194454459796478Rat
2313082Bss85Bone structure and strength QTL 850.80.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)181495133759951337Rat

1 to 10 of 34 rows
RH140704  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,928,725 - 21,928,934 (+)MAPPERmRatBN7.2
Rnor_6.01823,047,568 - 23,047,776NCBIRnor6.0
Rnor_5.01822,778,300 - 22,778,508UniSTSRnor5.0
RGSC_v3.41822,579,328 - 22,579,536UniSTSRGSC3.4
Celera1821,706,939 - 21,707,147UniSTS
RH 3.4 Map18265.3UniSTS
Cytogenetic Map18p12UniSTS
BF388154  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,908,980 - 21,909,136 (+)MAPPERmRatBN7.2
Rnor_6.01823,027,823 - 23,027,978NCBIRnor6.0
Rnor_5.01822,758,555 - 22,758,710UniSTSRnor5.0
RGSC_v3.41822,559,583 - 22,559,738UniSTSRGSC3.4
Celera1821,687,187 - 21,687,342UniSTS
RH 3.4 Map18264.2UniSTS
Cytogenetic Map18p12UniSTS
AU048898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21821,846,977 - 21,847,232 (+)MAPPERmRatBN7.2
Rnor_6.01822,965,826 - 22,966,080NCBIRnor6.0
Rnor_5.01822,696,558 - 22,696,812UniSTSRnor5.0
RGSC_v3.41822,496,813 - 22,497,067UniSTSRGSC3.4
Celera1821,626,032 - 21,626,286UniSTS
Cytogenetic Map18p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000066816   ⟹   ENSRNOP00000060791
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1821,845,295 - 21,929,048 (+)Ensembl
Rnor_6.0 Ensembl1822,964,210 - 23,047,895 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106926   ⟹   ENSRNOP00000080772
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1821,845,295 - 21,912,097 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109777   ⟹   ENSRNOP00000092703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1821,845,295 - 21,856,369 (+)Ensembl
RefSeq Acc Id: NM_022958   ⟹   NP_075247
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81822,119,857 - 22,203,546 (+)NCBI
mRatBN7.21821,845,362 - 21,929,054 (+)NCBI
Rnor_6.01822,964,210 - 23,047,896 (+)NCBI
Rnor_5.01822,694,862 - 22,778,628 (+)NCBI
RGSC_v3.41822,495,197 - 22,579,656 (+)RGD
Celera1821,624,416 - 21,707,267 (+)RGD
Sequence:
RefSeq Acc Id: XM_006254488   ⟹   XP_006254550
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81822,119,677 - 22,203,540 (+)NCBI
mRatBN7.21821,845,299 - 21,934,387 (+)NCBI
Rnor_6.01822,964,121 - 23,047,891 (+)NCBI
Rnor_5.01822,694,862 - 22,778,628 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097083   ⟹   XP_038953011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81822,119,763 - 22,186,206 (+)NCBI
mRatBN7.21821,845,282 - 21,911,713 (+)NCBI
RefSeq Acc Id: XM_063277567   ⟹   XP_063133637
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81822,119,771 - 22,186,207 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_075247 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254550 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953011 (Get FASTA)   NCBI Sequence Viewer  
  XP_063133637 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61981 (Get FASTA)   NCBI Sequence Viewer  
  CAA07199 (Get FASTA)   NCBI Sequence Viewer  
  EDL76162 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000060791
  ENSRNOP00000080772
GenBank Protein O88763 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_075247   ⟸   NM_022958
- UniProtKB: O88763 (UniProtKB/Swiss-Prot),   A6J2N0 (UniProtKB/TrEMBL),   A0A8I5ZQC6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006254550   ⟸   XM_006254488
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QUD7 (UniProtKB/TrEMBL),   A0A8I5ZQC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000060791   ⟸   ENSRNOT00000066816
RefSeq Acc Id: XP_038953011   ⟸   XM_039097083
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQC6 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000092703   ⟸   ENSRNOT00000109777
C2 PI3K-type   PI3K/PI4K catalytic   PIK helical

Name Modeler Protein Id AA Range Protein Structure
AF-O88763-F1-model_v2 AlphaFold O88763 1-887 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700670
Promoter ID:EPDNEW_R11194
Type:initiation region
Name:Pik3c3_1
Description:phosphatidylinositol 3-kinase, catalytic subunit type 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01822,964,176 - 22,964,236EPDNEW


1 to 40 of 49 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-8083 BioCyc
BioCyc Pathway PWY-6352 [3-phosphoinositide biosynthesis] BioCyc
BioCyc Pathway Image PWY-6352 BioCyc
Ensembl Genes ENSRNOG00000017840 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000066816 ENTREZGENE
  ENSRNOT00000106926 ENTREZGENE
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
  1.25.40.70 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5597998 IMAGE-MGC_LOAD
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PI3K_accessory_sf UniProtKB/Swiss-Prot
  PI3K_C2_dom UniProtKB/Swiss-Prot
  PI3K_Vps34 UniProtKB/Swiss-Prot
  PI_Kinase UniProtKB/Swiss-Prot
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
KEGG Report rno:65052 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72433 IMAGE-MGC_LOAD
NCBI Gene 65052 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3 UniProtKB/Swiss-Prot
  PTHR10048 UniProtKB/Swiss-Prot
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
PhenoGen Pik3c3 PhenoGen
PIRSF PI3K_Vps34 UniProtKB/Swiss-Prot
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PIK_HELICAL UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017840 RatGTEx
SMART PI3K_C2 UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
1 to 40 of 49 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3c3  phosphatidylinositol 3-kinase, catalytic subunit type 3  Pik3c3  phosphoinositide-3-kinase, class 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Pik3c3  phosphoinositide-3-kinase, class 3    phosphatidylinositol 3-kinase  Name updated 1299863 APPROVED
2002-08-07 Pik3c3  phosphatidylinositol 3-kinase      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_drugs inhibitors act on one transport step 628447
gene_process helps in the delivery of newly synthesized lysosomal hydrolases to lysosomes 628447