Herpud1 (homocysteine inducible ER protein with ubiquitin like domain 1) - Rat Genome Database

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Gene: Herpud1 (homocysteine inducible ER protein with ubiquitin like domain 1) Rattus norvegicus
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Symbol: Herpud1
Name: homocysteine inducible ER protein with ubiquitin like domain 1
RGD ID: 620818
Description: Predicted to enable transmembrane transporter binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in intracellular calcium ion homeostasis. Predicted to be located in Lewy body core; endoplasmic reticulum quality control compartment; and membrane. Predicted to be part of Hrd1p ubiquitin ligase complex. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human HERPUD1 (homocysteine inducible ER protein with ubiquitin like domain 1); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1; homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein; Sup
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,604,360 - 10,624,168 (-)NCBIGRCr8
mRatBN7.21910,598,411 - 10,609,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,598,417 - 10,618,424 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,561,735 - 10,572,117 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,328,571 - 11,338,953 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,615,556 - 10,625,938 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,046,905 - 11,057,440 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,046,909 - 11,057,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,027,622 - 11,038,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,036,567 - 11,046,914 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,041,392 - 11,051,740 (-)NCBI
Celera1910,486,005 - 10,496,352 (-)NCBICelera
Cytogenetic Map19p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Herpud1RatBardet-Biedl syndrome  ISOHERPUD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Bardet-Biedl syndromeClinVarPMID:11285252 more ...
Herpud1RatChromosome 16q12 Duplication Syndrome  ISOHERPUD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 16q12 duplication syndromeClinVarPMID:25741868
Herpud1Ratdevelopmental and epileptic encephalopathy  ISOHERPUD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:11285252 more ...
Herpud1Ratearly infantile epileptic encephalopathy  ISOHERPUD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:11285252 more ...
Herpud1Rathereditary breast ovarian cancer syndrome  ISOHERPUD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary breast ovarian cancer syndromeClinVarPMID:25741868
Object Symbol
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Reference
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Original Reference(s)
Herpud1RatProstatic Neoplasms  ISOHERPUD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17013881

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Object Symbol
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Original Reference(s)
Herpud1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of HERPUD1 mRNA]CTDPMID:31150632
Herpud1Rat(-)-epigallocatechin 3-gallate increases expressionISOHERPUD1 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of HERPUD1 mRNACTDPMID:16084531
Herpud1Rat1,2-dimethylhydrazine decreases expressionISOHerpud1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of HERPUD1 mRNACTDPMID:22206623
Herpud1Rat1-naphthyl isothiocyanate multiple interactionsISOHERPUD1 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of HERPUD1 mRNACTDPMID:27344345
Herpud1Rat14-Deoxy-11,12-didehydroandrographolide increases expressionISOHERPUD1 (Homo sapiens)648046414-deoxy-11 and 12-didehydroandrographolide results in increased expression of HERPUD1 mRNACTDPMID:22101062
Herpud1Rat17alpha-ethynylestradiol multiple interactionsISOHerpud1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HERPUD1 mRNACTDPMID:17942748
Herpud1Rat17beta-estradiol increases expressionISOHERPUD1 (Homo sapiens)6480464Estradiol results in increased expression of HERPUD1 mRNACTDPMID:20106945
Herpud1Rat17beta-estradiol decreases expressionISOHerpud1 (Mus musculus)6480464Estradiol results in decreased expression of HERPUD1 mRNACTDPMID:39298647
Herpud1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of HERPUD1 mRNACTDPMID:32145629
Herpud1Rat17beta-estradiol multiple interactionsISOHERPUD1 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of HERPUD1 mRNACTDPMID:30165855
Herpud1Rat17beta-estradiol affects expressionISOHerpud1 (Mus musculus)6480464Estradiol affects the expression of HERPUD1 mRNACTDPMID:15598610
Herpud1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOHerpud1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HERPUD1 mRNACTDPMID:17942748
Herpud1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of HERPUD1 mRNACTDPMID:33387578
Herpud1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHERPUD1 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of HERPUD1 mRNACTDPMID:22574217
Herpud1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of HERPUD1 mRNACTDPMID:21215274 and PMID:21724226
Herpud1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOHerpud1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of HERPUD1 mRNACTDPMID:21570461
Herpud1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of HERPUD1 mRNACTDPMID:22298810
Herpud1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOHerpud1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of HERPUD1 mRNACTDPMID:19770486
Herpud1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOHerpud1 (Mus musculus)64804642 more ...CTDPMID:38648751
Herpud1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of HERPUD1 mRNACTDPMID:21346803

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Biological Process
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Original Reference(s)
Herpud1Ratendoplasmic reticulum calcium ion homeostasis involved_inISOHERPUD1 (Homo sapiens)1624291 PMID:15102845 and PMID:22045699RGDPMID:15102845 and PMID:22045699
Herpud1Ratendoplasmic reticulum calcium ion homeostasis involved_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1Ratendoplasmic reticulum calcium ion homeostasis involved_inIBAPANTHER:PTN002658458 and UniProtKB:Q150111600115GO_REF:0000033GO_CentralGO_REF:0000033
Herpud1Ratendoplasmic reticulum unfolded protein response involved_inIBAFB:FBgn0031950 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Herpud1Ratendoplasmic reticulum unfolded protein response acts_upstream_of_or_withinISOHerpud1 (Mus musculus)1624291 PMID:10922362RGDPMID:10922362
Herpud1RatERAD pathway involved_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1RatERAD pathway involved_inISOHERPUD1 (Homo sapiens)1624291 PMID:28827405RGDPMID:28827405
Herpud1Ratintracellular calcium ion homeostasis  IMP 1304324 RGD 
Herpud1Ratnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway involved_inISOHERPUD1 (Homo sapiens)1624291 PMID:15102845RGDPMID:15102845
Herpud1Ratnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway involved_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1Ratnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway involved_inIBAPANTHER:PTN002658458 and UniProtKB:Q150111600115GO_REF:0000033GO_CentralGO_REF:0000033
Herpud1Ratnegative regulation of intrinsic apoptotic signaling pathway involved_inISOHERPUD1 (Homo sapiens)1624291UniProtKB:P37840 and PMID:22045699RGDPMID:22045699
Herpud1Ratnegative regulation of intrinsic apoptotic signaling pathway involved_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1Ratpositive regulation of ERAD pathway involved_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1Ratpositive regulation of ERAD pathway involved_inISOHERPUD1 (Homo sapiens)1624291 PMID:18307982 and PMID:22045699RGDPMID:18307982 and PMID:22045699
Herpud1Ratpositive regulation of ubiquitin-dependent protein catabolic process involved_inISOHERPUD1 (Homo sapiens)1624291 PMID:22045699RGDPMID:22045699
Herpud1Ratpositive regulation of ubiquitin-dependent protein catabolic process involved_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1Ratprotein targeting to ER involved_inISOHerpud1 (Mus musculus)1624291 PMID:24478453RGDPMID:24478453
Herpud1Ratregulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway involved_inISOHerpud1 (Mus musculus)1624291 PMID:15147274RGDPMID:15147274
Herpud1Ratregulation of ERAD pathway involved_inISOHerpud1 (Mus musculus)1624291 PMID:15147274RGDPMID:15147274
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Cellular Component
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Object Symbol
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Reference
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Original Reference(s)
Herpud1Ratendoplasmic reticulum located_inISOHERPUD1 (Homo sapiens)1624291 PMID:15102845 more ...RGDPMID:15102845 more ...
Herpud1Ratendoplasmic reticulum located_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1Ratendoplasmic reticulum located_inISOHerpud1 (Mus musculus)1624291 PMID:15147274RGDPMID:15147274
Herpud1Ratendoplasmic reticulum membrane located_inISOHERPUD1 (Homo sapiens)1624291 PMID:10922362RGDPMID:10922362
Herpud1Ratendoplasmic reticulum membrane located_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1Ratendoplasmic reticulum membrane located_inISOHerpud1 (Mus musculus)1624291 PMID:10922362RGDPMID:10922362
Herpud1Ratendoplasmic reticulum membrane is_active_inIBAMGI:1927406 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Herpud1Ratendoplasmic reticulum quality control compartment located_inISOHerpud1 (Mus musculus)1624291 PMID:24478453RGDPMID:24478453
Herpud1RatHrd1p ubiquitin ligase complex part_ofISOHERPUD1 (Homo sapiens)1624291 PMID:28827405RGDPMID:28827405
Herpud1RatHrd1p ubiquitin ligase complex part_ofIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1RatLewy body core located_inISOHERPUD1 (Homo sapiens)1624291 PMID:19788048RGDPMID:19788048
Herpud1RatLewy body core located_inIEAUniProtKB:Q15011 and ensembl:ENSP000004095551600115GO_REF:0000107EnsemblGO_REF:0000107
Herpud1Ratmembrane located_inISOHerpud1 (Mus musculus)1624291 PMID:10922362RGDPMID:10922362
Herpud1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function

  

Imported Annotations - KEGG (archival)

Object Symbol
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Source
Original Reference(s)
Herpud1RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141

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#
Reference Title
Reference Citation
1. The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant alpha-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins. Belal C, etal., Hum Mol Genet. 2012 Mar 1;21(5):963-77. doi: 10.1093/hmg/ddr502. Epub 2011 Nov 1.
2. Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress. Chan SL, etal., J Biol Chem 2004 Jul 2;279(27):28733-43. Epub 2004 Apr 21.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Role of Herp in the endoplasmic reticulum stress response. Hori O, etal., Genes Cells 2004 May;9(5):457-69.
6. Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress. Kokame K, etal., J Biol Chem 2000 Oct 20;275(42):32846-53.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic beta-cells. Tiwari A, etal., J Cell Sci. 2013 May 1;126(Pt 9):1962-8. doi: 10.1242/jcs.117374. Epub 2013 Feb 26.
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PMID:10708769   PMID:18307982   PMID:19788048   PMID:19946888   PMID:21600962   PMID:25637874   PMID:25660456   PMID:25792451   PMID:27871950   PMID:36812708  



Herpud1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,604,360 - 10,624,168 (-)NCBIGRCr8
mRatBN7.21910,598,411 - 10,609,002 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,598,417 - 10,618,424 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1910,561,735 - 10,572,117 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,328,571 - 11,338,953 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,615,556 - 10,625,938 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,046,905 - 11,057,440 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,046,909 - 11,057,254 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01911,027,622 - 11,038,305 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41911,036,567 - 11,046,914 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11911,041,392 - 11,051,740 (-)NCBI
Celera1910,486,005 - 10,496,352 (-)NCBICelera
Cytogenetic Map19p13NCBI
HERPUD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,932,142 - 56,944,864 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,932,142 - 56,944,864 (+)EnsemblGRCh38hg38GRCh38
GRCh371656,966,054 - 56,978,776 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,523,249 - 55,535,294 (+)NCBINCBI36Build 36hg18NCBI36
Build 341655,523,248 - 55,535,294NCBI
Celera1641,466,026 - 41,478,076 (+)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,835,319 - 42,847,282 (+)NCBIHuRef
CHM1_11658,373,967 - 58,385,760 (+)NCBICHM1_1
T2T-CHM13v2.01662,728,473 - 62,741,195 (+)NCBIT2T-CHM13v2.0
Herpud1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39895,113,057 - 95,121,999 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl895,113,066 - 95,122,005 (+)EnsemblGRCm39 Ensembl
GRCm38894,386,429 - 94,395,371 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,386,438 - 94,395,377 (+)EnsemblGRCm38mm10GRCm38
MGSCv37896,910,400 - 96,919,258 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36897,275,629 - 97,284,487 (+)NCBIMGSCv36mm8
Celera898,718,356 - 98,727,224 (+)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.46NCBI
Herpud1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,608,375 - 14,621,839 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543314,609,275 - 14,621,774 (+)NCBIChiLan1.0ChiLan1.0
HERPUD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21866,403,188 - 66,416,171 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11672,323,881 - 72,336,865 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01637,210,170 - 37,221,961 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11656,343,025 - 56,355,164 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1656,343,025 - 56,355,164 (+)Ensemblpanpan1.1panPan2
HERPUD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,388,492 - 59,400,028 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,388,494 - 59,400,003 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha256,017,333 - 56,028,868 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0259,927,541 - 59,939,082 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl259,927,546 - 59,939,082 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1256,758,736 - 56,770,263 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0257,766,037 - 57,777,356 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,660,262 - 58,671,800 (-)NCBIUU_Cfam_GSD_1.0
Herpud1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,486,978 - 50,497,944 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364759,091,176 - 9,102,109 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364759,091,115 - 9,102,101 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HERPUD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,901,297 - 18,913,424 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1618,901,171 - 18,913,427 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
HERPUD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,877,812 - 42,889,576 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,877,781 - 42,890,298 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604733,458,778 - 33,470,865 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Herpud1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474629,068,350 - 29,081,085 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474629,069,995 - 29,081,085 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Herpud1
62 total Variants

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:56
Interacting mature miRNAs:57
Transcripts:ENSRNOT00000025559
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat

1 to 10 of 19 rows
Herpud1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,598,550 - 10,598,772 (+)MAPPERmRatBN7.2
Rnor_6.01911,047,043 - 11,047,264NCBIRnor6.0
Rnor_5.01911,027,765 - 11,027,986UniSTSRnor5.0
Celera1910,486,141 - 10,486,362UniSTS
Cytogenetic Map19p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000025559   ⟹   ENSRNOP00000025559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,598,417 - 10,618,424 (-)Ensembl
Rnor_6.0 Ensembl1911,046,909 - 11,057,254 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110882   ⟹   ENSRNOP00000095807
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,598,417 - 10,618,418 (-)Ensembl
RefSeq Acc Id: NM_053523   ⟹   NP_445975
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,604,360 - 10,614,707 (-)NCBI
mRatBN7.21910,598,415 - 10,608,762 (-)NCBI
Rnor_6.01911,046,907 - 11,057,254 (-)NCBI
Rnor_5.01911,027,622 - 11,038,305 (-)NCBI
RGSC_v3.41911,036,567 - 11,046,914 (-)RGD
Celera1910,486,005 - 10,496,352 (-)RGD
Sequence:
RefSeq Acc Id: XM_006255133   ⟹   XP_006255195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,604,360 - 10,624,168 (-)NCBI
mRatBN7.21910,598,411 - 10,609,002 (-)NCBI
Rnor_6.01911,046,905 - 11,057,440 (-)NCBI
Rnor_5.01911,027,622 - 11,038,305 (-)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_445975 (Get FASTA)   NCBI Sequence Viewer  
  XP_006255195 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61849 (Get FASTA)   NCBI Sequence Viewer  
  BAB16047 (Get FASTA)   NCBI Sequence Viewer  
  EDL87344 (Get FASTA)   NCBI Sequence Viewer  
  EDL87345 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025559.4
  ENSRNOP00000095807
  ENSRNOP00000095807.1
1 to 9 of 9 rows
RefSeq Acc Id: NP_445975   ⟸   NM_053523
- UniProtKB: Q9ESS9 (UniProtKB/TrEMBL),   A6JY67 (UniProtKB/TrEMBL),   F7F5G8 (UniProtKB/TrEMBL),   Q6P739 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255195   ⟸   XM_006255133
- Peptide Label: isoform X1
- UniProtKB: A0A8I6B3C5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025559   ⟸   ENSRNOT00000025559
Ensembl Acc Id: ENSRNOP00000095807   ⟸   ENSRNOT00000110882
Ubiquitin-like

Name Modeler Protein Id AA Range Protein Structure
AF-Q9ESS9-F1-model_v2 AlphaFold Q9ESS9 1-391 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700946
Promoter ID:EPDNEW_R11470
Type:multiple initiation site
Name:Herpud1_1
Description:homocysteine inducible ER protein with ubiquitin like domain1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,057,260 - 11,057,320EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-6493 BioCyc
Ensembl Genes ENSRNOG00000018796 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025559.6 UniProtKB/TrEMBL
  ENSRNOT00000110882 ENTREZGENE
  ENSRNOT00000110882.1 UniProtKB/TrEMBL
Gene3D-CATH Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5621877 IMAGE-MGC_LOAD
InterPro HERPUD1/2 UniProtKB/TrEMBL
  Ubiquitin UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:85430 UniProtKB/TrEMBL
MGC_CLONE MGC:72340 IMAGE-MGC_LOAD
NCBI Gene 85430 ENTREZGENE
PANTHER HOMOCYSTEINE-RESPONSIVE ENDOPLASMIC RETICULUM-RESIDENT UBIQUITIN-LIKE DOMAIN MEMBER 1 PROTEIN UniProtKB/TrEMBL
  PTHR12943 UniProtKB/TrEMBL
Pfam ubiquitin UniProtKB/TrEMBL
PhenoGen Herpud1 PhenoGen
PROSITE UBIQUITIN_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018796 RatGTEx
SMART UBQ UniProtKB/TrEMBL
Superfamily-SCOP SSF54236 UniProtKB/TrEMBL
UniProt A0A8I6B3C5 ENTREZGENE, UniProtKB/TrEMBL
  A6JY66_RAT UniProtKB/TrEMBL
  A6JY67 ENTREZGENE, UniProtKB/TrEMBL
  F7F5G8 ENTREZGENE, UniProtKB/TrEMBL
  Q6P739 ENTREZGENE, UniProtKB/TrEMBL
  Q9ESS9 ENTREZGENE
UniProt Secondary Q9ESS9 UniProtKB/TrEMBL
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-29 Herpud1  homocysteine inducible ER protein with ubiquitin like domain 1  Herpud1  homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Herpud1  homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Herpud1  homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1      Symbol and Name status set to provisional 70820 PROVISIONAL