Map2k6 (mitogen-activated protein kinase kinase 6) - Rat Genome Database

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Gene: Map2k6 (mitogen-activated protein kinase kinase 6) Rattus norvegicus
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Symbol: Map2k6
Name: mitogen-activated protein kinase kinase 6
RGD ID: 620666
Description: Enables MAP kinase kinase activity. Involved in several processes, including cellular response to sorbitol; positive regulation of prostaglandin secretion; and response to ischemia. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Orthologous to human MAP2K6 (mitogen-activated protein kinase kinase 6); PARTICIPATES IN p38 MAPK signaling pathway; adenosine signaling pathway; cardiomyopathy pathway; INTERACTS WITH (S)-nicotine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: dual specificity mitogen-activated protein kinase kinase 6; MGC93287; Mkk6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81095,872,747 - 95,987,747 (+)NCBIGRCr8
GRCr8 Ensembl1095,872,546 - 95,987,721 (+)EnsemblGRCr8 Ensembl
mRatBN7.21095,373,304 - 95,490,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1095,373,204 - 95,488,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10100,429,713 - 100,544,144 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01099,892,740 - 100,007,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01095,301,015 - 95,415,445 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01098,707,160 - 98,823,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1098,706,960 - 98,823,287 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01098,413,927 - 98,527,709 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41099,859,684 - 99,974,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1094,024,106 - 94,137,678 (+)NCBICelera
RGSC_v3.11099,873,953 - 99,989,003 (+)NCBI
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Map2k6Ratallergic disease  ISOMAP2K6 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:21544193
Map2k6RatColonic Neoplasms  ISOMAP2K6 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15037631
Map2k6RatEdema  ISOMAP2K6 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:21544193
Map2k6RatProstatic Neoplasms  ISOMAP2K6 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:32512071

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Original Reference(s)
Map2k6Rat(-)-alpha-phellandrene increases expressionISOMAP2K6 (Homo sapiens)6480464alpha phellandrene results in increased expression of MAP2K6 mRNACTDPMID:25075043
Map2k6Rat(-)-epigallocatechin 3-gallate multiple interactionsISOMAP2K6 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MAP2K6 mRNACTDPMID:22079256
Map2k6Rat(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of MAP2K6 mRNACTDPMID:20426880
Map2k6Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane multiple interactionsISOMAP2K6 (Homo sapiens)6480464o,p'-DDT promotes the reaction [MAP2K6 protein results in increased activity of CREBBP protein]CTDPMID:22609851
Map2k6Rat1,2-dimethylhydrazine decreases expressionISOMap2k6 (Mus musculus)64804641,2-Dimethylhydrazine results in decreased expression of MAP2K6 mRNACTDPMID:22206623
Map2k6Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of MAP2K6 mRNACTDPMID:15834898
Map2k6Rat17alpha-ethynylestradiol affects expressionEXP 6480464Ethinyl Estradiol affects the expression of MAP2K6 mRNACTDPMID:26865667
Map2k6Rat17beta-estradiol multiple interactionsISOMap2k6 (Mus musculus)6480464ESR1 protein promotes the reaction [Estradiol results in decreased expression of MAP2K6 mRNA]CTDPMID:25210133
Map2k6Rat17beta-estradiol decreases expressionISOMAP2K6 (Homo sapiens)6480464Estradiol results in decreased expression of MAP2K6 mRNACTDPMID:31614463
Map2k6Rat17beta-estradiol multiple interactionsISOMAP2K6 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of MAP2K6 mRNA; [Progesterone co-treated with more ...CTDPMID:17404688|PMID:30165855
Map2k6Rat17beta-estradiol decreases expressionISOMap2k6 (Mus musculus)6480464Estradiol results in decreased expression of MAP2K6 mRNACTDPMID:25210133|PMID:39298647
Map2k6Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMap2k6 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MAP2K6 mRNACTDPMID:14708085
Map2k6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMAP2K6 (Homo sapiens)6480464Tetrachlorodibenzodioxin affects the expression of MAP2K6 mRNACTDPMID:22574217
Map2k6Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMap2k6 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MAP2K6 mRNACTDPMID:21570461|PMID:28922406
Map2k6Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of MAP2K6 mRNACTDPMID:21215274|PMID:33387578
Map2k6Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein alternative form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MAP2K6 mRNA]CTDPMID:21215274
Map2k6Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionISOMAP2K6 (Homo sapiens)64804642,2',4,4',5-brominated diphenyl ether results in decreased expression of MAP2K6 mRNACTDPMID:26705709
Map2k6Rat2-nitrofluorene decreases expressionEXP 64804642-nitrofluorene results in decreased expression of MAP2K6 mRNACTDPMID:22484513
Map2k6Rat3,3',4,4'-tetrachlorobiphenyl multiple interactionsISOMap2k6 (Mus musculus)64804643,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of MAP2K6 mRNA]CTDPMID:19467301
Map2k6Rat3,4-methylenedioxymethamphetamine increases expressionISOMap2k6 (Mus musculus)6480464N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of MAP2K6 mRNACTDPMID:26251327

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Biological Process
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Original Reference(s)
Map2k6Ratbone development involved_inISOMap2k6 (Mus musculus)1624291MGI:3696052 PMID:20551513RGDPMID:20551513
Map2k6Ratcardiac muscle contraction involved_inIEAARBA:ARBA000894761600115GO_REF:0000117UniProtGO_REF:0000117
Map2k6Ratcardiac muscle contraction acts_upstream_of_or_withinISOMap2k6 (Mus musculus)1624291MGI:2385922|MGI:3581034 PMID:11593045RGDPMID:11593045
Map2k6Ratcellular response to sorbitol  IEP 7243113 RGD 
Map2k6Ratcellular response to UV-B acts_upstream_of_or_withinISOMAP2K6 (Homo sapiens)1624291 PMID:35857590RGDPMID:35857590
Map2k6RatMAPK cascade involved_inISOMAP2K6 (Homo sapiens)1624291 PMID:8663074RGDPMID:8663074
Map2k6RatMAPK cascade acts_upstream_of_or_withinISOMap2k6 (Mus musculus)1624291PR:Q62073 PMID:12556533RGDPMID:12556533
Map2k6RatMAPK cascade involved_inIBAFB:FBgn0010269|FB:FBgn0024326|FB:FBgn0261524|MGI:1346345|MGI:1346866|MGI:1346867|MGI:1346868|MGI:1346869|MGI:1346870|MGI:1346871|PANTHER:PTN000684494|PomBase:SPAC1D4.13|PomBase:SPBC409.07c|PomBase:SPBC543.07|RGD:1560043|RGD:61890|SGD:S000002318|SGD:S000003664|SGD:S000005757|SGD:S000006061|UniProtKB:O14733|UniProtKB:P36507|UniProtKB:P46734|UniProtKB:P52564|WB:WBGene00003185|WB:WBGene00003186|WB:WBGene00003368|WB:WBGene000047581600115GO_REF:0000033GO_CentralGO_REF:0000033
Map2k6RatMAPK cascade involved_inISOMap2k6 (Mus musculus)1624291 PMID:20551513RGDPMID:20551513
Map2k6Ratnegative regulation of cold-induced thermogenesis involved_inISSUniProtKB:P7023613673736PMID:29021624YuBioLab 
Map2k6Ratnegative regulation of cold-induced thermogenesis involved_inISOMap2k6 (Mus musculus)1624291 PMID:29021624RGDPMID:29021624
Map2k6RatNLRP1 inflammasome complex assembly acts_upstream_of_or_withinISOMAP2K6 (Homo sapiens)1624291 PMID:22665479RGDPMID:22665479
Map2k6Ratosteoblast differentiation involved_inISOMap2k6 (Mus musculus)1624291 PMID:20551513RGDPMID:20551513
Map2k6Ratovulation cycle process  IEP 7495835 RGD 
Map2k6Ratp38MAPK cascade involved_inISOMAP2K6 (Homo sapiens)1624291 PMID:11460167RGDPMID:11460167
Map2k6Ratp38MAPK cascade acts_upstream_of_or_withinISOMAP2K6 (Homo sapiens)1624291 PMID:10330143RGDPMID:10330143
Map2k6Ratpositive regulation of apoptotic process  IMP 2293345TGF-beta1 treated FaO hepatoma cellsRGD 
Map2k6Ratpositive regulation of MAP kinase activity acts_upstream_of_or_withinISOMap2k6 (Mus musculus)1624291 PMID:14744933RGDPMID:14744933
Map2k6Ratpositive regulation of MAPK cascade acts_upstream_of_or_withinISOMap2k6 (Mus musculus)1624291MGI:1346868|MGI:1918084|MGI:2385922|MGI:3581034 PMID:11593045, PMID:15767678RGDPMID:11593045|PMID:15767678
Map2k6Ratpositive regulation of MAPK cascade involved_inIEAARBA:ARBA000272281600115GO_REF:0000117UniProtGO_REF:0000117
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Cellular Component

  
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Original Reference(s)
Map2k6Ratcytosol located_inISORGD:732805|UniProtKB:P52564-11624291 RGDGO_REF:0000052
Map2k6Ratcytosol is_active_inISOMAP2K6 (Homo sapiens)1624291 PMID:9768359RGDPMID:9768359
Map2k6Ratnucleoplasm located_inISORGD:732805|UniProtKB:P52564-11624291 RGDGO_REF:0000052

Molecular Function
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Original Reference(s)
Map2k6RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Map2k6RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Map2k6RatATP binding enablesIEAInterPro:IPR000719|InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Map2k6Ratidentical protein binding enablesISORGD:732805,UniProtKB:P52564-11624291UniProtKB:P52564-1 PMID:19141286RGDPMID:19141286
Map2k6Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Map2k6RatMAP kinase kinase activity  IDA 7243113 RGD 
Map2k6RatMAP kinase kinase activity enablesISOMap2k6 (Mus musculus)1624291 PMID:20551513RGDPMID:20551513
Map2k6RatMAP kinase kinase activity enablesIBACGD:CAL0000184846|FB:FBgn0010269|FB:FBgn0261524|MGI:1346345|MGI:1346866|MGI:1346867|MGI:1346868|MGI:1346870|MGI:1346871|PANTHER:PTN000684494|PomBase:SPAC1D4.13|PomBase:SPBC409.07c|PomBase:SPBC543.07|RGD:1560043|RGD:61888|RGD:620666|RGD:70495|SGD:S000002318|SGD:S000003664|TAIR:locus:2170578|UniProtKB:O14733|UniProtKB:P36507|UniProtKB:P46734|UniProtKB:P52564|UniProtKB:Q02750|UniProtKB:Q5BEU9|WB:WBGene00002177|WB:WBGene00003185|WB:WBGene000047581600115GO_REF:0000033GO_CentralGO_REF:0000033
Map2k6RatMAP kinase kinase activity enablesIEAARBA:ARBA000435551600115GO_REF:0000117UniProtGO_REF:0000117
Map2k6RatMAP kinase kinase activity enablesISOMAP2K6 (Homo sapiens)1624291 PMID:11460167, PMID:8663074, PMID:8663524, PMID:9218798RGDPMID:11460167|PMID:8663074|PMID:8663524|PMID:9218798
Map2k6Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Map2k6Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Map2k6Ratprotein binding enablesISOMAP2K6 (Homo sapiens)1624291UniProtKB:O76024|UniProtKB:P19525|UniProtKB:Q16236|UniProtKB:Q16539|UniProtKB:Q5S007|UniProtKB:Q9NRD5 PMID:11035004, PMID:15229216, PMID:17255949, PMID:20067578, PMID:32296183, PMID:32707033, PMID:32814053, PMID:32911434RGDPMID:11035004|PMID:15229216|PMID:17255949|PMID:20067578|PMID:32296183|PMID:32707033|PMID:32814053|PMID:32911434
Map2k6Ratprotein binding enablesISOMap2k6 (Mus musculus)1624291PR:Q62073 PMID:12556533RGDPMID:12556533
Map2k6Ratprotein kinase activity enablesIEAInterPro:IPR000719|InterPro:IPR0082711600115GO_REF:0000002InterProGO_REF:0000002
Map2k6Ratprotein kinase binding enablesISOMAP2K6 (Homo sapiens)1624291UniProtKB:Q9UL54 PMID:11279118RGDPMID:11279118
Map2k6Ratprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-07231600115GO_REF:0000043UniProtGO_REF:0000043
Map2k6Ratprotein tyrosine kinase activity enablesIEAUniProtKB-KW:KW-08291600115GO_REF:0000043UniProtGO_REF:0000043
Map2k6Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  
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Original Reference(s)
Map2k6Ratcardiomyopathy pathway  ISOMap2k6 (Mus musculus)9068941 RGDPMID:15722372|REF_RGD_ID:1582275
Map2k6Ratp38 MAPK signaling pathway   ISO2293891 RGD 
Map2k6Ratp38 MAPK signaling pathway   IDA 2298758 RGD 

Imported Annotations - SMPDB

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Original Reference(s)
Map2k6Ratadenosine signaling pathway  ISOMAP2K6 (Homo sapiens)10402751 SMPDBSMP:00321
Map2k6Ratadenosine signaling pathway  ISOMAP2K6 (Homo sapiens)10402751 SMPDBSMP:00320
Map2k6RatFc epsilon receptor mediated signaling pathway  ISOMAP2K6 (Homo sapiens)10402751 SMPDBSMP:00358

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)


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#
Reference Title
Reference Citation
1. The MKK6-p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT. Andrews C, etal., Cardiovasc Res 2003 Jul 1;59(1):46-56.
2. Targeted inhibition of p38 MAPK promotes hypertrophic cardiomyopathy through upregulation of calcineurin-NFAT signaling. Braz JC, etal., J Clin Invest. 2003 May;111(10):1475-86. doi: 10.1172/JCI17295.
3. Pro-life role for c-Jun N-terminal kinase and p38 mitogen-activated protein kinase at rostral ventrolateral medulla in experimental brain stem death. Chang AY J Biomed Sci. 2012 Nov 17;19:96. doi: 10.1186/1423-0127-19-96.
4. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
5. MAP kinase kinase 6-p38 MAP kinase signaling cascade regulates cyclooxygenase-2 expression in cardiac myocytes in vitro and in vivo. Degousee N, etal., Circ Res. 2003 Apr 18;92(7):757-64. Epub 2003 Mar 20.
6. The role of the MKK6/p38 MAPK pathway in Wip1-dependent regulation of ErbB2-driven mammary gland tumorigenesis. Demidov ON, etal., Oncogene. 2007 Apr 12;26(17):2502-6. Epub 2006 Oct 2.
7. Active kinase proteome screening reveals novel signal complexity in cardiomyopathy. Fernando P, etal., Mol Cell Proteomics. 2005 May;4(5):673-82. Epub 2005 Feb 18.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Both p38alpha(MAPK) and JNK/SAPK pathways are important for induction of nitric-oxide synthase by interleukin-1beta in rat glomerular mesangial cells. Guan Z, etal., J Biol Chem. 1999 Dec 17;274(51):36200-6.
11. Activation of ASK1, downstream MAPKK and MAPK isoforms during cardiac ischaemia. Harding SJ, etal., Biochim Biophys Acta. 2010 Sep;1802(9):733-40. doi: 10.1016/j.bbadis.2010.06.005. Epub 2010 Jun 13.
12. The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau. Hartzler AW, etal., Neurobiol Aging. 2002 Sep-Oct;23(5):855-9.
13. The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma. Hickson JA, etal., Cancer Res. 2006 Feb 15;66(4):2264-70.
14. Effects of sodium ferulate on amyloid-beta-induced MKK3/MKK6-p38 MAPK-Hsp27 signal pathway and apoptosis in rat hippocampus. Jin Y, etal., Acta Pharmacol Sin. 2006 Oct;27(10):1309-16.
15. Targeted inhibition of p38 mitogen-activated protein kinase antagonizes cardiac injury and cell death following ischemia-reperfusion in vivo. Kaiser RA, etal., J Biol Chem. 2004 Apr 9;279(15):15524-30. Epub 2004 Jan 28.
16. p38 MAPK and MAPK kinase 3/6 mRNA and activities are increased in early diabetic glomeruli. Kang SW, etal., Kidney Int. 2001 Aug;60(2):543-52.
17. p38 kinase is crucial for osteopontin-induced furin expression that supports cervical cancer progression. Kumar V, etal., Cancer Res. 2010 Dec 15;70(24):10381-91. doi: 10.1158/0008-5472.CAN-10-1470. Epub 2010 Oct 27.
18. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy. Liao P, etal., Proc Natl Acad Sci U S A 2001 Oct 9;98(21):12283-8. Epub 2001 Oct 02.
19. Up-regulation of MKK4, MKK6 and MKK7 during prostate cancer progression: an important role for SAPK signalling in prostatic neoplasia. Lotan TL, etal., J Pathol. 2007 Aug;212(4):386-94.
20. Developmental regulation of mitogen-activated protein kinase-activated kinases-2 and -3 (MAPKAPK-2/-3) in vivo during corpus luteum formation in the rat. Maizels ET, etal., Mol Endocrinol. 2001 May;15(5):716-33.
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PMID:8663524   PMID:9218798   PMID:11279118   PMID:12213961   PMID:12477932   PMID:12556533   PMID:14709549   PMID:14744933   PMID:15767678   PMID:19141286   PMID:23744074   PMID:24085465  



Map2k6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81095,872,747 - 95,987,747 (+)NCBIGRCr8
GRCr8 Ensembl1095,872,546 - 95,987,721 (+)EnsemblGRCr8 Ensembl
mRatBN7.21095,373,304 - 95,490,406 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1095,373,204 - 95,488,293 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx10100,429,713 - 100,544,144 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01099,892,740 - 100,007,172 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01095,301,015 - 95,415,445 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01098,707,160 - 98,823,054 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1098,706,960 - 98,823,287 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01098,413,927 - 98,527,709 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41099,859,684 - 99,974,446 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1094,024,106 - 94,137,678 (+)NCBICelera
RGSC_v3.11099,873,953 - 99,989,003 (+)NCBI
Cytogenetic Map10q32.1NCBI
MAP2K6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381769,414,697 - 69,553,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1769,414,697 - 69,553,865 (+)EnsemblGRCh38hg38GRCh38
GRCh371767,410,838 - 67,550,006 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,922,433 - 65,050,065 (+)NCBINCBI36Build 36hg18NCBI36
Build 341765,010,164 - 65,051,067NCBI
Celera1763,982,421 - 64,110,030 (+)NCBICelera
Cytogenetic Map17q24.3NCBI
HuRef1762,796,464 - 62,924,594 (+)NCBIHuRef
CHM1_11767,475,265 - 67,603,400 (+)NCBICHM1_1
T2T-CHM13v2.01770,291,653 - 70,430,810 (+)NCBIT2T-CHM13v2.0
Map2k6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911110,289,928 - 110,416,348 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11110,289,948 - 110,416,348 (+)EnsemblGRCm39 Ensembl
GRCm3811110,399,102 - 110,525,522 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11110,399,122 - 110,525,522 (+)EnsemblGRCm38mm10GRCm38
MGSCv3711110,260,436 - 110,374,951 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611110,215,212 - 110,329,727 (+)NCBIMGSCv36mm8
Celera11122,139,172 - 122,253,133 (+)NCBICelera
Cytogenetic Map11E1- E2NCBI
cM Map1173.6NCBI
Map2k6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554783,331,607 - 3,448,842 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554783,331,607 - 3,448,840 (-)NCBIChiLan1.0ChiLan1.0
MAP2K6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21985,434,352 - 85,573,837 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11790,255,171 - 90,400,452 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01763,342,720 - 63,483,926 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11768,730,011 - 68,870,713 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1768,730,011 - 68,870,454 (+)Ensemblpanpan1.1panPan2
MAP2K6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1915,840,714 - 15,962,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl915,840,983 - 15,952,026 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha916,731,937 - 16,853,765 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0917,501,891 - 17,623,440 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl917,501,897 - 17,614,738 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1916,445,924 - 16,567,352 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0910,966,413 - 11,088,091 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0910,965,262 - 11,086,973 (-)NCBIUU_Cfam_GSD_1.0
MAP2K6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1210,894,966 - 11,018,641 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11210,891,445 - 11,018,617 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,145,143 - 11,264,150 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAP2K6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11652,045,398 - 52,188,416 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1652,057,784 - 52,187,997 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607722,937,949 - 23,081,340 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Map2k6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248704,287,835 - 4,416,559 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248704,224,108 - 4,420,217 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Map2k6
1315 total Variants

Predicted Target Of
Summary Value
Count of predictions:54
Count of miRNA genes:52
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000006217
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 78 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
631558Bp137Blood pressure QTL 1370.013arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)109472486096836268Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat

1 to 10 of 78 rows
D10Mco69  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81095,953,412 - 95,953,648 (+)Marker Load Pipeline
mRatBN7.21095,453,982 - 95,454,218 (+)MAPPERmRatBN7.2
Rnor_6.01098,787,961 - 98,788,196NCBIRnor6.0
Rnor_5.01098,493,942 - 98,494,177UniSTSRnor5.0
RGSC_v3.41099,939,315 - 99,939,551RGDRGSC3.4
RGSC_v3.41099,939,316 - 99,939,551UniSTSRGSC3.4
Celera1094,103,581 - 94,103,816UniSTS
RGSC_v3.11099,953,685 - 99,953,921RGD
Cytogenetic Map10q32.1UniSTS
D10Chm249  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21095,445,008 - 95,445,251 (+)MAPPERmRatBN7.2
Rnor_6.01098,778,986 - 98,779,229NCBIRnor6.0
Rnor_5.01098,484,967 - 98,485,210UniSTSRnor5.0
RGSC_v3.41099,930,342 - 99,930,584UniSTSRGSC3.4
Celera1094,094,607 - 94,094,849UniSTS
Cytogenetic Map10q32.1UniSTS
Map2k6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21095,488,043 - 95,488,181 (+)MAPPERmRatBN7.2
Rnor_6.01098,822,976 - 98,823,113NCBIRnor6.0
Rnor_5.01098,527,631 - 98,527,768UniSTSRnor5.0
RGSC_v3.41099,974,368 - 99,974,505UniSTSRGSC3.4
Celera1094,137,600 - 94,137,737UniSTS
Cytogenetic Map10q32.1UniSTS
UniSTS:224328  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21095,487,684 - 95,487,876 (+)MAPPERmRatBN7.2
Rnor_6.01098,822,617 - 98,822,808NCBIRnor6.0
Rnor_5.01098,527,272 - 98,527,463UniSTSRnor5.0
RGSC_v3.41099,974,009 - 99,974,200UniSTSRGSC3.4
Celera1094,137,241 - 94,137,432UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000006217   ⟹   ENSRNOP00000006217
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1095,872,546 - 95,987,721 (+)Ensembl
mRatBN7.2 Ensembl1095,373,204 - 95,488,293 (+)Ensembl
Rnor_6.0 Ensembl1098,706,960 - 98,823,287 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000144844   ⟹   ENSRNOP00000112695
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1095,917,641 - 95,987,721 (+)Ensembl
RefSeq Acc Id: NM_053703   ⟹   NP_446155
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81095,872,747 - 95,987,550 (+)NCBI
mRatBN7.21095,373,304 - 95,488,122 (+)NCBI
Rnor_6.01098,707,160 - 98,823,054 (+)NCBI
Rnor_5.01098,413,927 - 98,527,709 (+)NCBI
RGSC_v3.41099,859,684 - 99,974,446 (+)RGD
Celera1094,024,106 - 94,137,678 (+)RGD
Sequence:
RefSeq Acc Id: XM_039085033   ⟹   XP_038940961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81095,946,846 - 95,987,747 (+)NCBI
mRatBN7.21095,447,420 - 95,490,406 (+)NCBI
RefSeq Acc Id: XM_039085034   ⟹   XP_038940962
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81095,873,037 - 95,987,747 (+)NCBI
mRatBN7.21095,382,182 - 95,490,406 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_446155 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940961 (Get FASTA)   NCBI Sequence Viewer  
  XP_038940962 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87004 (Get FASTA)   NCBI Sequence Viewer  
  AAK53428 (Get FASTA)   NCBI Sequence Viewer  
  EDM06489 (Get FASTA)   NCBI Sequence Viewer  
  EDM06490 (Get FASTA)   NCBI Sequence Viewer  
  EDM06491 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006217
  ENSRNOP00000006217.3
1 to 10 of 10 rows
RefSeq Acc Id: NP_446155   ⟸   NM_053703
- UniProtKB: Q925D6 (UniProtKB/TrEMBL),   A6HKD4 (UniProtKB/TrEMBL),   F7EK55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006217   ⟸   ENSRNOT00000006217
RefSeq Acc Id: XP_038940962   ⟸   XM_039085034
- Peptide Label: isoform X1
- UniProtKB: A6HKD7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038940961   ⟸   XM_039085033
- Peptide Label: isoform X1
- UniProtKB: A6HKD7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000112695   ⟸   ENSRNOT00000144844
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-Q925D6-F1-model_v2 AlphaFold Q925D6 1-334 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697867
Promoter ID:EPDNEW_R8391
Type:multiple initiation site
Name:Map2k6_1
Description:mitogen-activated protein kinase kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01098,707,000 - 98,707,060EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22816 BioCyc
Ensembl Genes ENSRNOG00000004437 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000006217 ENTREZGENE
  ENSRNOT00000006217.7 UniProtKB/TrEMBL
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7190965 IMAGE-MGC_LOAD
InterPro Kinase-like_dom UniProtKB/TrEMBL
  Prot_kinase_cat_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_prot_kinase_AS UniProtKB/TrEMBL
KEGG Report rno:114495 UniProtKB/TrEMBL
MGC_CLONE MGC:93287 IMAGE-MGC_LOAD
NCBI Gene 114495 ENTREZGENE
PANTHER DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED UniProtKB/TrEMBL
  DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 6 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PhenoGen Map2k6 PhenoGen
PIRSF Integrin-linked_kinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
RatGTEx ENSRNOG00000004437 RatGTEx
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP Kinase_like UniProtKB/TrEMBL
UniProt A6HKD4 ENTREZGENE
  A6HKD7 ENTREZGENE, UniProtKB/TrEMBL
  F7EK55 ENTREZGENE, UniProtKB/TrEMBL
  Q925D6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A6HKD4 UniProtKB/TrEMBL
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-01-20 Map2k6  mitogen-activated protein kinase kinase 6      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Map2k6  mitogen-activated protein kinase kinase 6      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_process prolongs the decay phase of the cardiac contractile calcium by downregulating SERCA2, increasing diastolic [Ca2+] 724424