Dnajc5 (DnaJ heat shock protein family (Hsp40) member C5) - Rat Genome Database

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Gene: Dnajc5 (DnaJ heat shock protein family (Hsp40) member C5) Rattus norvegicus
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Symbol: Dnajc5
Name: DnaJ heat shock protein family (Hsp40) member C5
RGD ID: 620516
Description: Enables ATP-dependent protein binding activity. Predicted to be involved in chaperone-mediated protein folding and regulation of synaptic vesicle cycle. Predicted to act upstream of or within negative regulation of neuron apoptotic process. Located in terminal bouton. Is active in synaptic vesicle membrane. Human ortholog(s) of this gene implicated in neuronal ceroid lipofuscinosis 4. Orthologous to human DNAJC5 (DnaJ heat shock protein family (Hsp40) member C5); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 17alpha-ethynylestradiol; 6-propyl-2-thiouracil; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Csp; cysteine string protein; DnaJ (Hsp40) homolog, subfamily C, member 5; dnaJ homolog subfamily C member 5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,999,508 - 189,033,455 (+)NCBIGRCr8
mRatBN7.23168,621,905 - 168,656,570 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,621,969 - 168,655,935 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3173,002,718 - 173,032,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,961,813 - 181,991,968 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,623,311 - 178,653,609 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03177,012,714 - 177,047,787 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,013,604 - 177,043,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,723,449 - 180,758,075 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,655,557 - 170,685,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,561,592 - 170,591,891 (+)NCBI
Celera3163,934,331 - 163,964,588 (-)NCBICelera
Cytogenetic Map3q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Dnajc5Ratautosomal dominant nocturnal frontal lobe epilepsy  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant nocturnal frontal lobe epilepsyClinVarPMID:24811917 more ...
Dnajc5Ratbenign familial infantile seizures 6  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: Autosomal dominant nocturnal frontal lobe epilepsyClinVarPMID:24811917 more ...
Dnajc5Ratdevelopmental and epileptic encephalopathy  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:14534157 more ...
Dnajc5Ratdevelopmental and epileptic encephalopathy 33  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: Epileptic encephalopathy more ...ClinVarPMID:24811917 more ...
Dnajc5Ratearly infantile epileptic encephalopathy  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:14534157 more ...
Dnajc5Ratepilepsy  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: SeizuresClinVarPMID:25741868 more ...
Dnajc5Ratgenetic disease  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Dnajc5Ratneuronal ceroid lipofuscinosis  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronal ceroid lipofuscinosisClinVarPMID:14534157 more ...
Dnajc5Ratneuronal ceroid lipofuscinosis  ISODNAJC5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Dnajc5Ratneuronal ceroid lipofuscinosis 4  ISODNAJC5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11489285 more ...
Dnajc5Ratprogressive myoclonus epilepsy  ISODNAJC5 (Homo sapiens)8554872ClinVar Annotator: match by term: Neuronal Ceroid-Lipofuscinosis and RecessiveClinVarPMID:25741868 more ...
Dnajc5Ratvisual epilepsy  ISODNAJC5 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
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Object Symbol
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Source
Original Reference(s)
Dnajc5Ratneuronal ceroid lipofuscinosis 4  ISODNAJC5 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Original Reference(s)
Dnajc5Rat1,2-dichloroethane decreases expressionISODnajc5 (Mus musculus)6480464ethylene dichloride results in decreased expression of DNAJC5 mRNACTDPMID:28960355
Dnajc5Rat1,2-dimethylhydrazine increases expressionISODnajc5 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of DNAJC5 mRNACTDPMID:22206623
Dnajc5Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of DNAJC5 mRNACTDPMID:29097150
Dnajc5Rat17beta-estradiol affects expressionISODNAJC5 (Homo sapiens)6480464Estradiol affects the expression of DNAJC5 mRNACTDPMID:22574217
Dnajc5Rat17beta-estradiol increases expressionISODnajc5 (Mus musculus)6480464Estradiol results in increased expression of DNAJC5 mRNACTDPMID:39298647
Dnajc5Rat17beta-estradiol increases expressionISODNAJC5 (Homo sapiens)6480464Estradiol results in increased expression of DNAJC5 mRNACTDPMID:23019147
Dnajc5Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISODnajc5 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of DNAJC5 mRNACTDPMID:21570461 and PMID:24680724
Dnajc5Rat2,6-dimethoxyphenol multiple interactionsISODNAJC5 (Homo sapiens)6480464[Sodium Chloride co-treated with pyrogallol 1 and 3-dimethyl ether] results in increased expression of and affects the localization of DNAJC5 proteinCTDPMID:38598786
Dnajc5Rat2-bromohexadecanoic acid multiple interactionsISODNAJC5 (Homo sapiens)64804642-bromopalmitate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased palmitoylation of DNAJC5 protein]CTDPMID:38195004
Dnajc5Rat3,4-methylenedioxymethamphetamine increases expressionISODnajc5 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of DNAJC5 mRNACTDPMID:20188158
Dnajc5Rat4,4'-diaminodiphenylmethane increases expressionISODnajc5 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of DNAJC5 mRNACTDPMID:18648102
Dnajc5Rat4,4'-sulfonyldiphenol increases expressionISODnajc5 (Mus musculus)6480464bisphenol S results in increased expression of DNAJC5 mRNACTDPMID:39298647
Dnajc5Rat6-propyl-2-thiouracil decreases expressionEXP 6480464Propylthiouracil results in decreased expression of DNAJC5 mRNACTDPMID:24780913
Dnajc5Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of DNAJC5 mRNACTDPMID:30047161
Dnajc5Ratacetamide decreases expressionEXP 6480464acetamide results in decreased expression of DNAJC5 mRNACTDPMID:31881176
Dnajc5Rataconitine decreases expressionEXP 6480464Aconitine results in decreased expression of DNAJC5 proteinCTDPMID:33236894
Dnajc5Rataflatoxin B1 increases expressionISODnajc5 (Mus musculus)6480464Aflatoxin B1 results in increased expression of DNAJC5 mRNACTDPMID:19770486
Dnajc5RatAflatoxin B2 alpha increases methylationISODNAJC5 (Homo sapiens)6480464aflatoxin B2 results in increased methylation of DNAJC5 intronCTDPMID:30157460
Dnajc5Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of DNAJC5 mRNACTDPMID:30047161
Dnajc5Ratammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of DNAJC5 mRNACTDPMID:16483693

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Biological Process
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Object Symbol
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Reference
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Original Reference(s)
Dnajc5Ratchaperone-mediated protein folding involved_inIBAMGI:892995 and PANTHER:PTN0028906261600115GO_REF:0000033GO_CentralGO_REF:0000033
Dnajc5Ratchaperone-mediated protein folding involved_inIEAUniProtKB:P60904 and ensembl:ENSMUSP000000721751600115GO_REF:0000107EnsemblGO_REF:0000107
Dnajc5Ratchaperone-mediated protein folding involved_inISODnajc5 (Mus musculus)1624291 PMID:21151134RGDPMID:21151134
Dnajc5Ratchemical synaptic transmission  TAS 632545 RGD 
Dnajc5Ratnegative regulation of neuron apoptotic process acts_upstream_of_or_withinIEAUniProtKB:P60904 and ensembl:ENSMUSP000000721751600115GO_REF:0000107EnsemblGO_REF:0000107
Dnajc5Ratnegative regulation of neuron apoptotic process acts_upstream_of_or_withinISODnajc5 (Mus musculus)1624291MGI:1277151 more ...RGDPMID:16269331
Dnajc5Ratneuron apoptotic process acts_upstream_ofIEAUniProtKB:P60904 and ensembl:ENSMUSP000000721751600115GO_REF:0000107EnsemblGO_REF:0000107
Dnajc5Ratneuron apoptotic process acts_upstream_ofISODnajc5 (Mus musculus)1624291MGI:1277151 more ...RGDPMID:16269331
Dnajc5Ratregulation of synaptic vesicle cycle involved_inIBAMGI:892995 and PANTHER:PTN0028906261600115GO_REF:0000033GO_CentralGO_REF:0000033
Dnajc5Ratregulation of synaptic vesicle cycle involved_inISODnajc5 (Mus musculus)1624291 PMID:22500637RGDPMID:22500637
Dnajc5Ratregulation of synaptic vesicle cycle involved_inIEAUniProtKB:P60904 and ensembl:ENSMUSP000000721751600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
1 to 20 of 29 rows

  
Object Symbol
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Reference
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Original Reference(s)
Dnajc5Ratchromaffin granule membrane located_inIEAUniProtKB-SubCell:SL-00621600115GO_REF:0000044UniProtGO_REF:0000044
Dnajc5Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Dnajc5Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Dnajc5Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Dnajc5Ratcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
Dnajc5Ratcytosol located_inISSUniProtKB:Q294551600115GO_REF:0000024UniProtGO_REF:0000024
Dnajc5Ratintracellular membrane-bounded organelle is_active_inIBAMGI:892995 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dnajc5Ratmelanosome located_inIEAUniProtKB-SubCell:SL-01611600115GO_REF:0000044UniProtGO_REF:0000044
Dnajc5Ratmembrane located_inISSUniProtKB:Q294551600115GO_REF:0000024UniProtGO_REF:0000024
Dnajc5Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Dnajc5Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Dnajc5Ratmembrane is_active_inIBAPANTHER:PTN002890626 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Dnajc5Ratneuromuscular junction is_active_inISODnajc5 (Mus musculus)1624291 PMID:22500637RGDPMID:22500637
Dnajc5Ratneuromuscular junction is_active_inIEAUniProtKB:P60904 and ensembl:ENSMUSP000000721751600115GO_REF:0000107EnsemblGO_REF:0000107
Dnajc5Ratplasma membrane located_inISODNAJC5 (Homo sapiens)1624291 PMID:21820099RGDPMID:21820099
Dnajc5Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Dnajc5Ratplasma membrane located_inIEAUniProtKB:Q9H3Z4 and ensembl:ENSP000003541111600115GO_REF:0000107EnsemblGO_REF:0000107
Dnajc5Ratplasma membrane located_inISSUniProtKB:Q9H3Z41600115GO_REF:0000024UniProtGO_REF:0000024
Dnajc5Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Dnajc5Ratpresynapse is_active_inIBAMGI:892995 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Molecular Function

  

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Dnajc5RatEndoplasmic Reticulum-associated degradation pathway  IEA 6907045 KEGGrno:04141

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#
Reference Title
Reference Citation
1. Rdj2, a J protein family member, interacts with cellular prion PrP(C). Beck KE, etal., Biochem Biophys Res Commun. 2006 Aug 4;346(3):866-71. Epub 2006 Jun 6.
2. Cysteine string protein, a DnaJ family member, is present on diverse secretory vesicles. Braun JE and Scheller RH, Neuropharmacology 1995 Nov;34(11):1361-9.
3. Phosphorylation-dependent interaction of the synaptic vesicle proteins cysteine string protein and synaptotagmin I. Evans GJ and Morgan A, Biochem J 2002 Jun 1;364(Pt 2):343-7.
4. Cysteine-string protein in inner hair cells of the organ of Corti: synaptic expression and upregulation at the onset of hearing. Eybalin M, etal., Eur J Neurosci 2002 May;15(9):1409-20.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. The nucleotide and deduced amino acid sequence of a rat cysteine string protein. Mastrogiacomo A and Gundersen CB, Brain Res Mol Brain Res 1995 Jan;28(1):12-8.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin. Miller LC, etal., J Biol Chem 2003 Dec 26;278(52):53072-81. Epub 2003 Oct 21.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Rab-alphaGDI activity is regulated by a Hsp90 chaperone complex. Sakisaka T, etal., EMBO J 2002 Nov 15;21(22):6125-35.
16. Oligomerization characteristics of cysteine string protein. Swayne LA, etal., Biochem Biophys Res Commun 2003 Jan 24;300(4):921-6.
17. A brain-specific isoform of small glutamine-rich tetratricopeptide repeat-containing protein binds to Hsc70 and the cysteine string protein. Tobaben S, etal., J Biol Chem 2003 Oct 3;278(40):38376-83. Epub 2003 Jul 23.
18. A trimeric protein complex functions as a synaptic chaperone machine. Tobaben S, etal., Neuron. 2001 Sep 27;31(6):987-99.
19. Composition of isolated synaptic boutons reveals the amounts of vesicle trafficking proteins. Wilhelm BG, etal., Science. 2014 May 30;344(6187):1023-8. doi: 10.1126/science.1252884.
20. Induction of cysteine string protein after chronic antidepressant treatment in rat frontal cortex. Yamada M, etal., Neurosci Lett 2001 Apr 6;301(3):183-6.
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PMID:12783986   PMID:15926915   PMID:15972823   PMID:16269331   PMID:16396499   PMID:16407767   PMID:17113038   PMID:17897319   PMID:18596047   PMID:19282376   PMID:19946888   PMID:20833797  
PMID:21151134   PMID:21820099   PMID:22500637   PMID:22666389   PMID:22871113   PMID:23376485   PMID:23942053   PMID:24956274  



Dnajc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83188,999,508 - 189,033,455 (+)NCBIGRCr8
mRatBN7.23168,621,905 - 168,656,570 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3168,621,969 - 168,655,935 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3173,002,718 - 173,032,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03181,961,813 - 181,991,968 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03178,623,311 - 178,653,609 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03177,012,714 - 177,047,787 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3177,013,604 - 177,043,902 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03180,723,449 - 180,758,075 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43170,655,557 - 170,685,855 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13170,561,592 - 170,591,891 (+)NCBI
Celera3163,934,331 - 163,964,588 (-)NCBICelera
Cytogenetic Map3q43NCBI
DNAJC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382063,895,126 - 63,936,011 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2063,895,126 - 63,936,031 (+)EnsemblGRCh38hg38GRCh38
GRCh372062,526,479 - 62,567,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362061,996,962 - 62,035,839 (+)NCBINCBI36Build 36hg18NCBI36
Build 342061,996,961 - 62,035,838NCBI
Celera2059,210,381 - 59,249,259 (+)NCBICelera
Cytogenetic Map20q13.33NCBI
HuRef2059,258,875 - 59,300,772 (+)NCBIHuRef
CHM1_12062,427,271 - 62,467,998 (+)NCBICHM1_1
T2T-CHM13v2.02065,714,973 - 65,755,860 (+)NCBIT2T-CHM13v2.0
Dnajc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392181,162,141 - 181,194,679 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2181,162,278 - 181,196,926 (+)EnsemblGRCm39 Ensembl
GRCm382181,518,858 - 181,552,886 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2181,520,485 - 181,555,133 (+)EnsemblGRCm38mm10GRCm38
MGSCv372181,255,210 - 181,286,954 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362181,449,912 - 181,481,656 (+)NCBIMGSCv36mm8
Celera2185,601,949 - 185,633,720 (+)NCBICelera
Cytogenetic Map2H4NCBI
cM Map2103.63NCBI
Dnajc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955528317,891 - 366,293 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955528317,891 - 366,299 (-)NCBIChiLan1.0ChiLan1.0
DNAJC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22169,707,007 - 69,748,067 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12069,699,028 - 69,740,072 (+)NCBINHGRI_mPanPan1
PanPan1.12061,848,236 - 61,856,265 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2061,848,236 - 61,856,265 (+)Ensemblpanpan1.1panPan2
DNAJC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ROS_Cfam_1.02448,520,496 - 48,548,620 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2448,514,370 - 48,545,332 (+)EnsemblROS_Cfam_1.0 Ensembl
Dnajc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640195,630,910 - 195,685,765 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493651411,131,074 - 11,139,446 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493651411,131,666 - 11,139,404 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNAJC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1762,754,802 - 62,780,468 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11762,754,630 - 62,780,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
DNAJC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12303,195 - 310,618 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2307,988 - 310,475 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605047,836,851 - 47,872,106 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dnajc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474129,515,298 - 29,562,617 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474129,515,338 - 29,562,619 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Dnajc5
65 total Variants

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:46
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000020581
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3131635904169034231Rat
1300161Rf10Renal function QTL 103.57renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)3161192952169034231Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)343827364169034231Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3130656562169034231Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3145956084169034231Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3141074471169034231Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3130656562169034231Rat
2317883Alcrsp26Alcohol response QTL 261.80.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)3145526770169034231Rat
8552952Pigfal13Plasma insulin-like growth factor 1 level QTL 13blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)3138799500169034231Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3124122556169034231Rat

1 to 10 of 11 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_001431433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_024161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_197211 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_197212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_197213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_197214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762544 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_352967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_352968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC118105 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF323955 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474066 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S81917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U39320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000020581   ⟹   ENSRNOP00000020581
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,621,969 - 168,652,678 (+)Ensembl
Rnor_6.0 Ensembl3177,013,604 - 177,043,902 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086046   ⟹   ENSRNOP00000070142
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3177,040,707 - 177,043,381 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102827   ⟹   ENSRNOP00000078729
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,621,986 - 168,655,935 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000111615   ⟹   ENSRNOP00000088442
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl3168,621,986 - 168,655,649 (+)Ensembl
RefSeq Acc Id: NM_024161   ⟹   NP_077075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,999,902 - 189,030,200 (+)NCBI
mRatBN7.23168,622,380 - 168,652,680 (+)NCBI
Rnor_6.03177,013,604 - 177,043,902 (+)NCBI
Rnor_5.03180,723,449 - 180,758,075 (+)NCBI
RGSC_v3.43170,655,557 - 170,685,855 (+)RGD
Celera3163,934,331 - 163,964,588 (-)RGD
Sequence:
RefSeq Acc Id: XM_008762544   ⟹   XP_008760766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,999,508 - 189,033,455 (+)NCBI
mRatBN7.23168,621,920 - 168,656,570 (+)NCBI
Rnor_6.03177,012,718 - 177,047,787 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008762545   ⟹   XP_008760767
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,999,509 - 189,033,455 (+)NCBI
mRatBN7.23168,621,916 - 168,656,570 (+)NCBI
Rnor_6.03177,012,717 - 177,047,787 (+)NCBI
Sequence:
RefSeq Acc Id: XR_352967
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,999,508 - 189,033,455 (+)NCBI
mRatBN7.23168,621,920 - 168,656,570 (+)NCBI
Rnor_6.03177,012,718 - 177,047,787 (+)NCBI
Rnor_5.03180,723,449 - 180,758,075 (+)NCBI
Sequence:
RefSeq Acc Id: XR_352968
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83188,999,508 - 189,030,020 (+)NCBI
mRatBN7.23168,621,914 - 168,656,570 (+)NCBI
Rnor_6.03177,012,714 - 177,047,787 (+)NCBI
Rnor_5.03180,723,449 - 180,758,075 (+)NCBI
Sequence:
RefSeq Acc Id: NP_077075   ⟸   NM_024161
- UniProtKB: P60905 (UniProtKB/Swiss-Prot),   A6KLZ8 (UniProtKB/TrEMBL),   A0A8I6A9F3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008760766   ⟸   XM_008762544
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008760767   ⟸   XM_008762545
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000020581   ⟸   ENSRNOT00000020581
Ensembl Acc Id: ENSRNOP00000070142   ⟸   ENSRNOT00000086046
J

Name Modeler Protein Id AA Range Protein Structure
AF-P60905-F1-model_v2 AlphaFold P60905 1-198 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 27 of 27 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-46274 BioCyc
Ensembl Genes ENSRNOG00000015202 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000020581.4 UniProtKB/Swiss-Prot
  ENSRNOT00000102827 ENTREZGENE
Gene3D-CATH 1.10.287.110 UniProtKB/Swiss-Prot
InterPro DnaJ_C_subfamily_member5 UniProtKB/Swiss-Prot
  DnaJ_domain UniProtKB/Swiss-Prot
  DnaJ_domain_CS UniProtKB/Swiss-Prot
  J_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:79130 UniProtKB/Swiss-Prot
NCBI Gene 79130 ENTREZGENE
PANTHER DNAJ HOMOLOG SUBFAMILY C MEMBER 5 UniProtKB/Swiss-Prot
  DNAJ HOMOLOG SUBFAMILY C MEMBER 5 HOMOLOG UniProtKB/Swiss-Prot
Pfam DnaJ UniProtKB/Swiss-Prot
PhenoGen Dnajc5 PhenoGen
PRINTS JDOMAIN UniProtKB/Swiss-Prot
PROSITE DNAJ_1 UniProtKB/Swiss-Prot
  DNAJ_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000015202 RatGTEx
SMART DnaJ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF46565 UniProtKB/Swiss-Prot
UniProt A0A0G2JX56_RAT UniProtKB/TrEMBL
  A0A8I6A9F3 ENTREZGENE, UniProtKB/TrEMBL
  A6KLZ8 ENTREZGENE, UniProtKB/TrEMBL
  A6KLZ9_RAT UniProtKB/TrEMBL
  DNJC5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary P54101 UniProtKB/Swiss-Prot
1 to 27 of 27 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Dnajc5  DnaJ heat shock protein family (Hsp40) member C5  Dnajc5  DnaJ (Hsp40) homolog, subfamily C, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Dnajc5  DnaJ (Hsp40) homolog, subfamily C, member 5    cysteine string protein  Name updated 1299863 APPROVED
2004-09-10 Dnajc5  cysteine string protein  Csp    Symbol and Name updated 1299863 APPROVED
2002-08-07 Csp  cysteine string protein      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_physical_interaction forms homo-oligomers with itself 632545
gene_physical_interaction forms a complex with Hsp90 and Hsc70 in synaptic membranes 632546