Gstm3 (glutathione S-transferase mu 3) - Rat Genome Database

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Gene: Gstm3 (glutathione S-transferase mu 3) Rattus norvegicus
Analyze
Symbol: Gstm3
Name: glutathione S-transferase mu 3
RGD ID: 620381
Description: Predicted to enable glutathione transferase activity and identical protein binding activity. Predicted to act upstream of or within cellular response to xenobiotic stimulus and response to bacterium. Predicted to be located in cytoplasm. Biomarker of hypertension; PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; .
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase M3; glutathione S-transferase M4; glutathione S-transferase mu 3-like; glutathione S-transferase mu 3-like 1; glutathione S-transferase Yb4; glutathione S-transferase Yb4 gene; glutathione S-transferase, mu 3; Gstm3l; Gstm3l1; Gstm4; GstYb4
RGD Orthologs
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,295,442 - 198,300,742 (-)NCBIGRCr8
mRatBN7.22195,590,450 - 195,612,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,607,289 - 195,612,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,250,033 - 203,254,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,132,155 - 201,136,917 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,949,108 - 195,953,870 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,761,729 - 210,766,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,761,729 - 210,766,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,213,463 - 230,235,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,532,363 - 203,537,135 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,495,116 - 203,499,889 (-)NCBI
Celera2188,254,140 - 188,258,912 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 13 of 13 rows

  
1 to 13 of 13 rows


Biological Process

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm3Ratcellular response to xenobiotic stimulus acts_upstream_of_or_withinISOGstm3 (Mus musculus)1624291 PMID:8512323RGDPMID:8512323
Gstm3Ratresponse to bacterium acts_upstream_of_or_withinISOGstm3 (Mus musculus)1624291 PMID:23012479RGDPMID:23012479

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044

Molecular Function

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm3Ratglutathione transferase activity enablesIEAInterPro:IPR0030811600115GO_REF:0000002InterProGO_REF:0000002
Gstm3Ratidentical protein binding enablesIEAARBA:ARBA000279301600115GO_REF:0000117UniProtGO_REF:0000117
Gstm3Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm3Ratglutathione conjugation pathway  ISS 1358120 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm3Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gstm3Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gstm3Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

1 to 20 of 20 rows
#
Reference Title
Reference Citation
1. Variation in genes relevant to aromatic hydrocarbon metabolism and the risk of adult brain tumors. De Roos AJ, etal., Neuro Oncol. 2006 Apr;8(2):145-55. Epub 2006 Jan 27.
2. Glutathione-S-transferase M1, M3, P1 and T1 polymorphisms and severity of lung disease in children with cystic fibrosis. Flamant C, etal., Pharmacogenetics. 2004 May;14(5):295-301.
3. Expression profiling identifies genes involved in emphysema severity. Francis SM, etal., Respir Res. 2009 Sep 2;10:81.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Proteomic analysis of peripheral T-lymphocytes in patients with asthma. Jeong HC, etal., Chest. 2007 Aug;132(2):489-96. Epub 2007 Jun 5.
6. Glutathione S-transferase GSTM3 and GSTP1 genotypes and larynx cancer risk. Jourenkova-Mironova N, etal., Cancer Epidemiol Biomarkers Prev. 1999 Feb;8(2):185-8.
7. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
8. Gene expression of rat glutathione S-transferases. Evidence for gene conversion in the evolution of the Yb multigene family. Lai HC, etal., J Biol Chem 1988 Aug 15;263(23):11389-95.
9. A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. Maes OC, etal., Neurobiol Aging. 2010 Jan;31(1):34-45. Epub 2008 Apr 17.
10. Glutathione S-transferase polymorphisms in MS: their relationship to disability. Mann CL, etal., Neurology. 2000 Feb 8;54(3):552-7.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Glutathione S-transferase genotypes and allergic responses to diisocyanate exposure. Piirila P, etal., Pharmacogenetics. 2001 Jul;11(5):437-45.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Rationale for reclassification of a distinctive subdivision of mammalian class Mu glutathione S-transferases that are primarily expressed in testis. Rowe JD, etal., J Biol Chem 1998 Apr 17;273(16):9593-601.
17. Glutathione S-transferase polymorphisms in osteosarcoma patients. Salinas-Souza C, etal., Pharmacogenet Genomics. 2010 Aug;20(8):507-15.
18. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. Seymour EM, etal., J Nutr Biochem. 2013 Sep;24(9):1580-6. doi: 10.1016/j.jnutbio.2013.01.008. Epub 2013 Mar 22.
19. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
20. Glutathione S-transferase hGSTM3 and ageing-associated neurodegeneration: relationship to Alzheimer's disease. Tchaikovskaya T, etal., Mech Ageing Dev. 2005 Feb;126(2):309-15.
1 to 20 of 20 rows
PMID:10587441   PMID:22871113   PMID:25416956   PMID:25931508  



Gstm3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,295,442 - 198,300,742 (-)NCBIGRCr8
mRatBN7.22195,590,450 - 195,612,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,607,289 - 195,612,475 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,250,033 - 203,254,795 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,132,155 - 201,136,917 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,949,108 - 195,953,870 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,761,729 - 210,766,501 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,761,729 - 210,766,501 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,213,463 - 230,235,414 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,532,363 - 203,537,135 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,495,116 - 203,499,889 (-)NCBI
Celera2188,254,140 - 188,258,912 (-)NCBICelera
Cytogenetic Map2q34NCBI
Gstm3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,871,019 - 107,876,484 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,871,012 - 107,876,599 (-)EnsemblGRCm39 Ensembl
GRCm383107,963,696 - 107,969,174 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,963,696 - 107,969,283 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,766,614 - 107,772,076 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,091,752 - 108,097,214 (-)NCBIMGSCv36mm8
Celera3110,296,772 - 110,302,234 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI

.

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Variants in Gstm3
117 total Variants

Predicted Target Of
Summary Value
Count of predictions:71
Count of miRNA genes:70
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000025800
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 65 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat

1 to 10 of 65 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 12 32 76 78 59 7 59 6 144 35 19 40 41 19



Ensembl Acc Id: ENSRNOT00000025800   ⟹   ENSRNOP00000025800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2210,761,729 - 210,766,501 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000051261   ⟹   ENSRNOP00000044720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,607,289 - 195,612,475 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000072342   ⟹   ENSRNOP00000065389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,531,495 - 195,534,553 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090430   ⟹   ENSRNOP00000070934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,531,916 - 195,534,553 (+)Ensembl
RefSeq Acc Id: NM_020540   ⟹   NP_065415
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,295,442 - 198,300,667 (-)NCBI
mRatBN7.22195,607,278 - 195,612,503 (-)NCBI
Rnor_6.02210,761,729 - 210,766,501 (-)NCBI
Rnor_5.02230,213,463 - 230,235,414 (-)NCBI
RGSC_v3.42203,532,363 - 203,537,135 (-)RGD
Celera2188,254,140 - 188,258,912 (-)RGD
Sequence:
RefSeq Acc Id: XM_039103003   ⟹   XP_038958931
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,295,442 - 198,300,734 (-)NCBI
mRatBN7.22195,607,278 - 195,612,519 (-)NCBI
RefSeq Acc Id: XR_005500356
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,297,852 - 198,300,742 (-)NCBI
mRatBN7.22195,609,688 - 195,612,578 (-)NCBI
Protein RefSeqs NP_065415 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958931 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD22630 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044720
  ENSRNOP00000044720.6
RefSeq Acc Id: NP_065415   ⟸   NM_020540
- UniProtKB: D3ZVQ8 (UniProtKB/TrEMBL),   A6HUW7 (UniProtKB/TrEMBL),   Q9WU21 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000025800   ⟸   ENSRNOT00000025800
RefSeq Acc Id: XP_038958931   ⟸   XM_039103003
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000044720   ⟸   ENSRNOT00000051261
Ensembl Acc Id: ENSRNOP00000070934   ⟸   ENSRNOT00000090430
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-G3V8H3-F1-model_v2 AlphaFold G3V8H3 1-218 view protein structure
AF-D3ZVQ8-F1-model_v2 AlphaFold D3ZVQ8 1-235 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691667
Promoter ID:EPDNEW_R2192
Type:initiation region
Name:Gstm3l_1
Description:glutathione S-transferase mu 3-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,766,529 - 210,766,589EPDNEW


1 to 34 of 34 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51646 BioCyc
Ensembl Genes ENSRNOG00000019058 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000049743 Ensembl
Ensembl Transcript ENSRNOT00000051261 ENTREZGENE
  ENSRNOT00000051261.7 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/TrEMBL
InterPro Glutathione-S-Trfase_C-like UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/TrEMBL
  GST_C UniProtKB/TrEMBL
  GST_mu UniProtKB/TrEMBL
  GST_superfamily UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/TrEMBL
KEGG Report rno:57298 UniProtKB/TrEMBL
NCBI Gene 57298 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE MU 1-RELATED UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE MU 7 UniProtKB/TrEMBL
Pfam GST_C UniProtKB/TrEMBL
  GST_N UniProtKB/TrEMBL
PhenoGen Gstm3 PhenoGen
PRINTS GSTRNSFRASEM UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/TrEMBL
  GST_NTER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019058 RatGTEx
  ENSRNOG00000049743 RatGTEx
Superfamily-SCOP GST_C_like UniProtKB/TrEMBL
  Thiordxn-like_fd UniProtKB/TrEMBL
UniProt A6HUW2_RAT UniProtKB/TrEMBL
  A6HUW7 ENTREZGENE, UniProtKB/TrEMBL
  D3ZVQ8 ENTREZGENE, UniProtKB/TrEMBL
  Q9WU21 ENTREZGENE, UniProtKB/TrEMBL
1 to 34 of 34 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-11-18 Gstm3  glutathione S-transferase mu 3  Gstm3l1  glutathione S-transferase mu 3-like 1  Data merged from RGD:11402080 737654 PROVISIONAL
2021-11-04 Gstm3  glutathione S-transferase mu 3  Gstm3l  glutathione S-transferase mu 3-like  Name and Symbol changed 629549 APPROVED
2021-11-04 Gstm3l1  glutathione S-transferase mu 3-like 1  Gstm3  glutathione S-transferase mu 3  Name and Symbol changed 629549 APPROVED
2017-02-10 Gstm3  glutathione S-transferase mu 3  NEWGENE_620381  glutathione S-transferase mu 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2017-02-10 Gstm3l  glutathione S-transferase mu 3-like  Gstm3  glutathione S-transferase mu 3  Name and Symbol changed 629549 APPROVED
2009-02-04 Gstm3  glutathione S-transferase mu 3  Gstm3  glutathione S-transferase M3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-03 Gstm3  glutathione S-transferase M3  Gstm3  glutathione S-transferase, mu 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-25 Gstm3  glutathione S-transferase, mu 3  Gstm4  glutathione S-transferase M4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Gstm4  glutathione S-transferase M4  GstYb4  glutathione S-transferase Yb4 gene  Symbol and Name updated 1299863 APPROVED
2002-08-07 GstYb4  glutathione S-transferase Yb4 gene      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in liver 632976