Ran (RAN, member RAS oncogene family) - Rat Genome Database

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Gene: Ran (RAN, member RAS oncogene family) Rattus norvegicus
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Symbol: Ran
Name: RAN, member RAS oncogene family
RGD ID: 620367
Description: Enables several functions, including dynein intermediate chain binding activity; guanyl ribonucleotide binding activity; and importin-alpha family protein binding activity. Involved in cellular response to mineralocorticoid stimulus; hippocampus development; and spermatid development. Located in male germ cell nucleus; manchette; and sperm flagellum. Part of nuclear pore. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family); PARTICIPATES IN CRM1 export pathway; microRNA pathway; nuclear factor kappa B signaling pathway; INTERACTS WITH (+)-schisandrin B; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-bromopropane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: GTP-binding nuclear protein Ran; GTPase Ran; ras-like protein TC4; ras-related nuclear protein
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81233,311,155 - 33,314,339 (-)NCBIGRCr8
mRatBN7.21227,674,049 - 27,678,598 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,674,050 - 27,678,276 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1228,814,245 - 28,817,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01229,424,809 - 29,427,937 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01228,483,802 - 28,486,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01231,319,556 - 31,324,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1231,320,624 - 31,323,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,245,991 - 33,250,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,736,786 - 28,739,921 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,600,176 - 28,603,309 (-)NCBI
Celera1229,370,202 - 29,373,337 (-)NCBICelera
Cytogenetic Map12q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
RanRatsciatic neuropathy  IDA 9835000 RGD 
RanRattype 1 diabetes mellitus  ISORAN (Homo sapiens)9835390human gene in a mouse modelRGD 
Object Symbol
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Original Reference(s)
RanRatAnimal Mammary Neoplasms  ISORAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 and PMID:16316942
RanRatcarcinoma  ISORAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 and PMID:16316942
RanRatExperimental Mammary Neoplasms  ISORAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12376462 and PMID:16316942
RanRathuman immunodeficiency virus infectious disease  ISORAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15308739
RanRatKeloid  ISORAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20128793
RanRatosteoarthritis  ISORAN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18784066

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Original Reference(s)
RanRat(+)-catechin multiple interactionsISORAN (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of RAN mRNACTDPMID:24763279
RanRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of RAN mRNA]CTDPMID:31150632
RanRat(-)-epigallocatechin 3-gallate increases expressionISORAN (Homo sapiens)6480464epigallocatechin gallate results in increased expression of RAN proteinCTDPMID:31195006
RanRat(1->4)-beta-D-glucan multiple interactionsISORan (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of RAN mRNACTDPMID:36331819
RanRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of RAN mRNACTDPMID:17984292
RanRat1,2-dichloroethane increases expressionISORan (Mus musculus)6480464ethylene dichloride results in increased expression of RAN mRNACTDPMID:28960355
RanRat1,2-dimethylhydrazine multiple interactionsISORan (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RAN mRNACTDPMID:22206623
RanRat1-bromopropane increases expressionEXP 64804641-bromopropane results in increased expression of RAN proteinCTDPMID:21925529
RanRat1-bromopropane increases expressionISORan (Mus musculus)64804641-bromopropane results in increased expression of RAN proteinCTDPMID:27421776
RanRat17alpha-ethynylestradiol increases expressionISORan (Mus musculus)6480464Ethinyl Estradiol results in increased expression of RAN mRNACTDPMID:16174780 and PMID:19400957
RanRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of RAN mRNACTDPMID:16174780 more ...
RanRat17beta-estradiol affects expressionISORAN (Homo sapiens)6480464Estradiol affects the expression of RAN mRNACTDPMID:21826169
RanRat17beta-estradiol increases expressionISORan (Mus musculus)6480464Estradiol results in increased expression of RAN mRNACTDPMID:39298647
RanRat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of RAN mRNACTDPMID:32145629
RanRat17beta-estradiol multiple interactionsISORAN (Homo sapiens)6480464[Estradiol co-treated with Bucladesine co-treated with Medroxyprogesterone Acetate] results in decreased expression of RAN mRNACTDPMID:20823114
RanRat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISORan (Mus musculus)64804642 more ...CTDPMID:30294300
RanRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORan (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of RAN mRNACTDPMID:21570461
RanRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of RAN mRNACTDPMID:34747641
RanRat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISORan (Mus musculus)64804642 more ...CTDPMID:38648751
RanRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of RAN mRNACTDPMID:21346803

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Biological Process
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Original Reference(s)
RanRatactin cytoskeleton organization acts_upstream_of_or_withinISORan (Mus musculus)1624291 PMID:21874009RGDPMID:21874009
RanRatactin cytoskeleton organization acts_upstream_of_or_withinIEAUniProtKB:P62827 and ensembl:ENSMUSP000001069751600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
RanRatcellular response to mineralocorticoid stimulus  IEP 9835351aldosteroneRGD 
RanRatGTP metabolic process involved_inISSUniProtKB:P628261600115GO_REF:0000024UniProtGO_REF:0000024
RanRatGTP metabolic process involved_inIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatGTP metabolic process involved_inISORAN (Homo sapiens)1624291 PMID:26272610RGDPMID:26272610
RanRathippocampus development  IEP 2302825 RGD 
RanRatmitotic sister chromatid segregation involved_inISSUniProtKB:P628261600115GO_REF:0000024UniProtGO_REF:0000024
RanRatmitotic sister chromatid segregation involved_inIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatmitotic sister chromatid segregation involved_inISORAN (Homo sapiens)1624291 PMID:29040603RGDPMID:29040603
RanRatnucleocytoplasmic transport  TAS 727421 RGD 
RanRatnucleocytoplasmic transport involved_inIEAARBA:ARBA000277581600115GO_REF:0000117UniProtGO_REF:0000117
RanRatnucleocytoplasmic transport involved_inIEAInterPro:IPR0020411600115GO_REF:0000002InterProGO_REF:0000002
RanRatpositive regulation of protein export from nucleus involved_inISORAN (Canis lupus familiaris)1624291 PMID:15602554RGDPMID:15602554
RanRatpositive regulation of protein import into nucleus involved_inISORAN (Homo sapiens)1624291 PMID:18691641RGDPMID:18691641
RanRatpositive regulation of protein import into nucleus involved_inIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatprotein export from nucleus  TAS 727421 RGD 
RanRatprotein export from nucleus involved_inIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatprotein export from nucleus involved_inISORAN (Homo sapiens)1624291 PMID:10944119 more ...RGDPMID:10944119 more ...
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Cellular Component
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Original Reference(s)
RanRatcentriole located_inISORAN (Homo sapiens)1624291 PMID:19166812RGDPMID:19166812
RanRatcentriole located_inIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatchromatin located_inISORAN (Homo sapiens)1624291 PMID:1961752RGDPMID:1961752
RanRatchromatin located_inIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatcytoplasm located_inISORAN (Homo sapiens)1624291 PMID:1961752 and PMID:26308891RGDPMID:1961752 and PMID:26308891
RanRatcytoplasm located_inIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatcytoplasm located_inIEAUniProtKB:P62827 and ensembl:ENSMUSP000001069751600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
RanRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
RanRatcytoplasm located_inISORan (Mus musculus)1624291 PMID:18347012RGDPMID:18347012
RanRatcytoplasm is_active_inIBAFB:FBgn0020255 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RanRatcytosol located_inIEAUniProtKB-SubCell:SL-00911600115GO_REF:0000044UniProtGO_REF:0000044
RanRatFlemming body NOT|located_inISORAN (Homo sapiens)1624291 PMID:19166812RGDPMID:19166812
RanRatmale germ cell nucleus  IDA 633049 RGD 
RanRatmanchette  IDA 727421 RGD 
RanRatmelanosome located_inIEAUniProtKB-SubCell:SL-01611600115GO_REF:0000044UniProtGO_REF:0000044
RanRatmidbody located_inISORAN (Homo sapiens)1624291 PMID:19166812RGDPMID:19166812
RanRatmidbody located_inIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatnuclear envelope located_inISORan (Mus musculus)1624291 PMID:25946333RGDPMID:25946333
RanRatnuclear envelope located_inIEAUniProtKB-SubCell:SL-01781600115GO_REF:0000044UniProtGO_REF:0000044
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Molecular Function
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Original Reference(s)
RanRatdynein intermediate chain binding  IDA 9835000 RGD 
RanRatG protein activity enablesISORAN (Homo sapiens)1624291 PMID:11336674RGDPMID:11336674
RanRatG protein activity enablesIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatGDP binding  IDA 4145659 RGD 
RanRatGDP binding enablesIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatGDP binding enablesISORAN (Homo sapiens)1624291 PMID:11336674 more ...RGDPMID:11336674 more ...
RanRatGTP binding  IDA 4145659 RGD 
RanRatGTP binding enablesIEAInterPro:IPR001806 more ...1600115GO_REF:0000002InterProGO_REF:0000002
RanRatGTP binding enablesIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
RanRatGTP binding enablesISORAN (Homo sapiens)1624291 PMID:11336674 more ...RGDPMID:11336674 more ...
RanRatGTP binding enablesISORAN (Canis lupus familiaris)1624291 PMID:15602554 and PMID:19965479RGDPMID:15602554 and PMID:19965479
RanRatGTPase activity  TAS 727421 RGD 
RanRatGTPase activity enablesIEAInterPro:IPR001806 and InterPro:IPR0020411600115GO_REF:0000002InterProGO_REF:0000002
RanRatGTPase activity enablesIEAUniProtKB:P62826 and ensembl:ENSP000004462151600115GO_REF:0000107EnsemblGO_REF:0000107
RanRatGTPase activity enablesIBACGD:CAL0000182095 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RanRatGTPase activity enablesISORAN (Homo sapiens)1624291 PMID:26272610 and PMID:8636225RGDPMID:26272610 and PMID:8636225
RanRatGTPase activity enablesISSUniProtKB:P628261600115GO_REF:0000024UniProtGO_REF:0000024
RanRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
RanRatimportin-alpha family protein binding  IDA 9835000 RGD 
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RGD Manual Annotations


  
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Original Reference(s)
RanRatCRM1 export pathway  ISORAN (Homo sapiens)9743967 RGD 
RanRatmicroRNA pathway   ISORAN (Homo sapiens)4144860 RGD 
RanRatribosome biogenesis pathway   ISORAN (Homo sapiens)10002749 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
RanRatribosome biogenesis pathway   IEA 6907045 KEGGrno:03008
RanRatRNA transport pathway  IEA 6907045 KEGGrno:03013

Imported Annotations - PID (archival)

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Original Reference(s)
RanRatnuclear factor kappa B signaling pathway   ISORAN (Homo sapiens)6484113 PIDPID:200031

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#
Reference Title
Reference Citation
1. Separate binding sites on nuclear transport factor 2 (NTF2) for GDP-Ran and the phenylalanine-rich repeat regions of nucleoporins p62 and Nsp1p. Clarkson WD, etal., J Mol Biol. 1996 Nov 8;263(4):517-24.
2. RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complex. Delphin C, etal., Mol Biol Cell. 1997 Dec;8(12):2379-90.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Vasopressin V1a receptor is required for nucleocytoplasmic transport of mineralocorticoid receptor. Hori K, etal., Am J Physiol Renal Physiol. 2012 Oct;303(7):F1080-8. doi: 10.1152/ajprenal.00052.2012. Epub 2012 Jul 18.
5. Ran, a GTP-binding protein involved in nucleocytoplasmic transport and microtubule nucleation, relocates from the manchette to the centrosome region during rat spermiogenesis. Kierszenbaum AL, etal., Mol Reprod Dev 2002 Sep;63(1):131-40.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Postage for the messenger: designating routes for nuclear mRNA export. Natalizio BJ and Wente SR, Trends Cell Biol. 2013 Aug;23(8):365-73. doi: 10.1016/j.tcb.2013.03.006. Epub 2013 Apr 11.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. A high-resolution structure of the pre-microRNA nuclear export machinery. Okada C, etal., Science. 2009 Nov 27;326(5957):1275-9.
10. Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenzanthracene. Papaconstantinou AD, etal., Int J Cancer. 2006 Jan 1;118(1):17-24.
11. Crystallographic and biochemical analysis of the Ran-binding zinc finger domain. Partridge JR and Schwartz TU, J Mol Biol. 2009 Aug 14;391(2):375-89. Epub 2009 Jun 6.
12. Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein import. Percipalle P, etal., J Mol Biol. 1997 Mar 7;266(4):722-32.
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
19. Changes of hippocampal signaling protein levels during postnatal brain development in the rat. Weitzdorfer R, etal., Hippocampus. 2008;18(8):807-13.
20. Essential role of the small GTPase Ran in postnatal pancreatic islet development. Xia F, etal., PLoS One. 2011;6(11):e27879. doi: 10.1371/journal.pone.0027879. Epub 2011 Nov 17.
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PMID:1961752   PMID:8636225   PMID:8757804   PMID:9533885   PMID:9822603   PMID:10557333   PMID:11336674   PMID:11809816   PMID:12773398   PMID:14681208   PMID:15489334   PMID:15574332  
PMID:15602554   PMID:15689618   PMID:16449645   PMID:18266911   PMID:18347012   PMID:18691641   PMID:18938132   PMID:19056867   PMID:19166812   PMID:19946888   PMID:20458337   PMID:20478346  
PMID:21630459   PMID:21874009   PMID:22658674   PMID:22681889   PMID:22871113   PMID:23029267   PMID:23106098   PMID:23376485   PMID:23979707   PMID:24561039   PMID:24625528   PMID:25468996  
PMID:25779090   PMID:25946333   PMID:26272610   PMID:26308891   PMID:27541860   PMID:29040603   PMID:30053369   PMID:31075303   PMID:32357304  



Ran
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81233,311,155 - 33,314,339 (-)NCBIGRCr8
mRatBN7.21227,674,049 - 27,678,598 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1227,674,050 - 27,678,276 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1228,814,245 - 28,817,373 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01229,424,809 - 29,427,937 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01228,483,802 - 28,486,937 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01231,319,556 - 31,324,105 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1231,320,624 - 31,323,810 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01233,245,991 - 33,250,540 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41228,736,786 - 28,739,921 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11228,600,176 - 28,603,309 (-)NCBI
Celera1229,370,202 - 29,373,337 (-)NCBICelera
Cytogenetic Map12q13NCBI
RAN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812130,872,066 - 130,877,678 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12130,872,037 - 130,877,678 (+)EnsemblGRCh38hg38GRCh38
GRCh3712131,356,611 - 131,362,223 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612129,922,521 - 129,927,316 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412129,881,447 - 129,886,243NCBI
Celera12130,970,022 - 130,974,231 (+)NCBICelera
Cytogenetic Map12q24.33NCBI
HuRef12128,338,826 - 128,343,035 (+)NCBIHuRef
CHM1_112131,177,378 - 131,181,587 (+)NCBICHM1_1
T2T-CHM13v2.012130,911,164 - 130,916,776 (+)NCBIT2T-CHM13v2.0
Ran
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395129,097,264 - 129,101,388 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5129,097,133 - 129,101,387 (+)EnsemblGRCm39 Ensembl
GRCm385129,020,156 - 129,024,322 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5129,020,069 - 129,024,323 (+)EnsemblGRCm38mm10GRCm38
MGSCv375129,526,031 - 129,530,196 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365129,334,926 - 129,339,029 (+)NCBIMGSCv36mm8
Celera5126,055,157 - 126,059,295 (+)NCBICelera
Cytogenetic Map5G1.3NCBI
cM Map567.99NCBI
Ran
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554821,220,876 - 1,224,395 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554821,222,944 - 1,223,891 (-)NCBIChiLan1.0ChiLan1.0
RAN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210138,943,846 - 138,949,523 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112138,940,386 - 138,946,040 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012128,497,407 - 128,503,049 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112132,694,498 - 132,699,668 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12132,694,498 - 132,699,668 (+)Ensemblpanpan1.1panPan2
RAN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1261,435,077 - 1,436,893 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl261,434,720 - 1,436,993 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha261,635,546 - 1,637,515 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0261,680,668 - 1,683,666 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl261,679,342 - 1,685,209 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1261,617,356 - 1,619,315 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0261,714,300 - 1,716,258 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0261,621,482 - 1,623,431 (-)NCBIUU_Cfam_GSD_1.0
Ran
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118123,047,105 - 123,050,801 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366601,668,956 - 1,672,067 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366601,669,352 - 1,673,972 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1424,311,577 - 24,317,789 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11424,312,810 - 24,318,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21425,861,945 - 25,865,060 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RAN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111126,257,849 - 126,263,481 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037118,757,304 - 118,763,095 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ran
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474727,285,934 - 27,290,667 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474727,287,510 - 27,290,082 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ran
19 total Variants


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
12 28737744 28737745 G C snv FHH/EurMcwi (MCW), BN/SsN (KNAW), SR/JrHsd (MCW), FHL/EurMcwi (MCW) View more Information
12 28737953 28737954 C A snv LCR/2Mco (UMich), HCR/1Mco (UMich), COP/CrCrl (MCW & UW) View more Information
12 28738034 28738035 T C snv HCR/2Mco (UMich) View more Information
12 28738041 28738042 C T snv ACI/EurMcwi (MCW), SS/JrHsdMcwi (MCW), BUF/N (KNAW), COP/CrCrl (MCW & UW), LEW/Crl (ICL), LEW/NCrl (ICL), SS/Jr (ICL), SS/JrHsdMcwi (ICL), HCR/1Mco (UMich), LCR/2Mco (UMich), HCR/2Mco (UMich), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), SR/JrHsd (MCW), SHRSP/Gcrc (MDC), ACI/N (KNAW), BN/SsN (KNAW), BN/NHsdMcwi (KNAW), F344/NRrrc (KNAW), LE/Stm (KNAW), M520/N (KNAW), MR/N (KNAW), WKY/N (KNAW), WN/N (KNAW), GH/OmrMcwi (MCW), BN-Lx/Cub (ICL), BN/NHsdMcwi (ICL), ACI/EurMcwi (ICL), BBDP/WorN (ICL), F344/NCrl (ICL), FHH/EurMcwi (ICL), FHL/EurMcwi (ICL), GK/Ox (ICL), LE/Stm (ICL), LH/MavRrrc (ICL), LL/MavRrrc (ICL), LN/MavRrrc (ICL), MHS/Gib (ICL), MNS/Gib (ICL), SBH/Ygl (ICL), SBN/Ygl (ICL), SHR/OlaIpcv (ICL), SHR/NHsd (ICL), SHRSP/Gcrc (ICL), SR/JrHsd (ICL), WAG/Rij (ICL), WKY/NCrl (ICL), WKY/Gcrc (ICL), WKY/NHsd (ICL), LCR/1Mco (UMich) View more Information
12 28738068 28738069 G A snv ACI/EurMcwi (MCW), FHH/EurMcwi (MCW), LCR/2Mco (UMich), HCR/2Mco (UMich), LCR/1Mco (UMich), HCR/1Mco (UMich), GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW), WN/N (KNAW), WKY/N (KNAW), MR/N (KNAW), FHL/EurMcwi (MCW), SR/JrHsd (MCW), SS/JrHsdMcwi (MCW), ACI/N (KNAW), BN/SsN (KNAW), BN/NHsdMcwi (KNAW), BUF/N (KNAW), F344/NRrrc (KNAW), LE/Stm (KNAW), M520/N (KNAW) View more Information
12 28738103 28738104 A G snv HCR/1Mco (UMich), GH/OmrMcwi (MCW), COP/CrCrl (MCW & UW), SS/JrHsdMcwi (MCW), HCR/2Mco (UMich), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW), ACI/EurMcwi (MCW), LCR/1Mco (UMich), SR/JrHsd (MCW) View more Information


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
12 31321578 31321579 G C snv BN/SsN (MCW) View more Information
12 31321875 31321876 C T snv WN/N (MCW), WKY/N (MCW), BN/SsN (MCW), M520/N (MCW), F344/NRrrc (MCW), Buf/N (MCW), ACI/N (MCW), MR/N (MCW) View more Information
12 31321902 31321903 G A snv WKY/N (MCW), MR/N (MCW), M520/N (MCW), F344/NRrrc (MCW), Buf/N (MCW), BN/SsN (MCW), ACI/N (MCW), European Variation Archive Release 6, European Variation Archive Release 4, WN/N (MCW), European Variation Archive Release 3 View more Information

Predicted Target Of
Summary Value
Count of predictions:60
Count of miRNA genes:50
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000001247, ENSRNOT00000074908
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 53 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)121914436246669029Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122308134044726024Rat
61324Eae5Experimental allergic encephalomyelitis QTL 514nervous system integrity trait (VT:0010566)percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)121961087046669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
737822Alc10Alcohol consumption QTL 102.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)121961087040218516Rat
2293684Bmd26Bone mineral density QTL 264.40.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)121587265332974238Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122413920236638073Rat

1 to 10 of 53 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_001436423 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_053439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006249285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF306457 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214720 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222288 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229342 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000012 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000001247   ⟹   ENSRNOP00000001247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1227,674,050 - 27,678,276 (-)Ensembl
Rnor_6.0 Ensembl1231,320,624 - 31,323,810 (-)Ensembl
RefSeq Acc Id: NM_053439   ⟹   NP_445891
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,311,155 - 33,314,290 (-)NCBI
mRatBN7.21227,675,113 - 27,678,248 (-)NCBI
Rnor_6.01231,320,620 - 31,323,755 (-)NCBI
Rnor_5.01233,245,991 - 33,250,540 (-)NCBI
RGSC_v3.41228,736,786 - 28,739,921 (-)RGD
Celera1229,370,202 - 29,373,337 (-)RGD
Sequence:
RefSeq Acc Id: XM_006249285   ⟹   XP_006249347
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81233,311,155 - 33,314,339 (-)NCBI
mRatBN7.21227,674,049 - 27,678,598 (-)NCBI
Rnor_6.01231,319,556 - 31,324,105 (-)NCBI
Rnor_5.01233,245,991 - 33,250,540 (-)NCBI
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_001423352 (Get FASTA)   NCBI Sequence Viewer  
  NP_445891 (Get FASTA)   NCBI Sequence Viewer  
  XP_006249347 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG33229 (Get FASTA)   NCBI Sequence Viewer  
  AAH59123 (Get FASTA)   NCBI Sequence Viewer  
  EDM13511 (Get FASTA)   NCBI Sequence Viewer  
  EDM13512 (Get FASTA)   NCBI Sequence Viewer  
  EDM13513 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001247
  ENSRNOP00000001247.4
GenBank Protein P62828 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_445891   ⟸   NM_053439
- UniProtKB: P62828 (UniProtKB/Swiss-Prot),   A6J0S3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006249347   ⟸   XM_006249285
- Peptide Label: isoform X1
- UniProtKB: P62828 (UniProtKB/Swiss-Prot),   A6J0S3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001247   ⟸   ENSRNOT00000001247

Name Modeler Protein Id AA Range Protein Structure
AF-P62828-F1-model_v2 AlphaFold P62828 1-216 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698593
Promoter ID:EPDNEW_R9118
Type:initiation region
Name:Ran_1
Description:RAN, member RAS oncogene family
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01231,323,770 - 31,323,830EPDNEW


1 to 36 of 36 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-19469 BioCyc
Ensembl Genes ENSRNOG00000000938 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001247 ENTREZGENE
  ENSRNOT00000001247.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920235 IMAGE-MGC_LOAD
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Ran_GTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
KEGG Report rno:84509 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72745 IMAGE-MGC_LOAD
NCBI Gene 84509 ENTREZGENE
PANTHER GTP-BINDING NUCLEAR PROTEIN RAN UniProtKB/Swiss-Prot
  PTHR24071 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PhenoGen Ran PhenoGen
PRINTS GTPRANTC4 UniProtKB/Swiss-Prot
PROSITE RAN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000938 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAN UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A6J0S3 ENTREZGENE, UniProtKB/TrEMBL
  A6J0S4_RAT UniProtKB/TrEMBL
  P62828 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P17080 UniProtKB/Swiss-Prot
  P28746 UniProtKB/Swiss-Prot
  P28747 UniProtKB/Swiss-Prot
  Q9CSP3 UniProtKB/Swiss-Prot
  Q9CWI7 UniProtKB/Swiss-Prot
  Q9CZA2 UniProtKB/Swiss-Prot
  Q9UDJ5 UniProtKB/Swiss-Prot
  Q9UEU9 UniProtKB/Swiss-Prot
1 to 36 of 36 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Ran  RAN, member RAS oncogene family      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Ran  RAN, member RAS oncogene family      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_cellular_localization localized to the manchette microtubules of elongating spermatids and later to the centrosome of maturing spermatids 727421