Abcc4 (ATP binding cassette subfamily C member 4) - Rat Genome Database

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Gene: Abcc4 (ATP binding cassette subfamily C member 4) Rattus norvegicus
Analyze
Symbol: Abcc4
Name: ATP binding cassette subfamily C member 4
RGD ID: 620266
Description: Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Involved in positive regulation of smooth muscle cell proliferation and response to tetrachloromethane. Located in basolateral plasma membrane and external side of apical plasma membrane. Biomarker of cholestasis and extrahepatic cholestasis. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4 (PEL blood group)); PARTICIPATES IN azathioprine pharmacodynamics pathway; lamivudine pharmacokinetics pathway; mercaptopurine pharmacodynamics pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ABC-tranporter; ATP-binding cassette protein C4; ATP-binding cassette subfamily C member 4; ATP-binding cassette, sub-family C (CFTR/MRP), member 4; ATP-binding cassette, subfamily C (CFTR/MRP), member 4; LOC306166; Mrp4; multidrug resistance-associated protein 4; RGD1565953; similar to multidrug resistance-associated protein 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815101,948,387 - 102,182,912 (-)NCBIGRCr8
GRCr8 Ensembl15101,949,433 - 102,181,375 (-)EnsemblGRCr8 Ensembl
mRatBN7.21595,541,186 - 95,774,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1595,542,315 - 95,774,283 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1599,449,698 - 99,683,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015100,581,669 - 100,815,501 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01597,510,336 - 97,744,179 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015103,695,415 - 103,927,980 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015107,127,408 - 107,356,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415103,384,848 - 103,611,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1594,392,176 - 94,624,412 (-)NCBICelera
RGSC_v3.115103,416,404 - 103,417,006 (-)NCBI
Cytogenetic Map15q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Abcc4Ratcholestasis  IEP 2301085protein:altered expression:kidney, liverRGD 
Abcc4Ratcholestasis treatmentIEP 15045612 RGD 
Abcc4Ratextrahepatic cholestasis treatmentIEP 14995480mRNA:increased expression:liver (rat)RGD 
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Original Reference(s)
Abcc4RatAnal Atresia, Hypospadias, and Penoscrotal Inversion  ISOABCC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Anal atresia, hypospadias, and penoscrotal inversionClinVarPMID:31690835
Abcc4Ratholoprosencephaly 5  ISOABCC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Holoprosencephaly 5ClinVarPMID:17274816|PMID:19955556|PMID:28492532|PMID:29770992
Abcc4Ratprostate cancer  ISOABCC4 (Homo sapiens)8554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
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Abcc4Ratcognitive disorder  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29382564
Abcc4RatColorectal Neoplasms  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22294766
Abcc4RatDiabetes Complications  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29382564
Abcc4RatDrug-Related Side Effects and Adverse Reactions  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23222202
Abcc4Ratendometriosis  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25446850
Abcc4RatNeoplasm Metastasis  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17003774
Abcc4RatProstatic Neoplasms  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17003774
Abcc4Ratrheumatoid arthritis  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23897011
Abcc4Ratsubstance-related disorder  ISOABCC4 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20098672
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Original Reference(s)
Abcc4Rat(-)-epigallocatechin 3-gallate increases expressionEXP 6480464epigallocatechin gallate results in increased expression of ABCC4 proteinCTDPMID:23146761
Abcc4Rat(1->4)-beta-D-glucan multiple interactionsISOAbcc4 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of ABCC4 mRNACTDPMID:36331819
Abcc4Rat(S)-colchicine multiple interactionsISOAbcc4 (Mus musculus)6480464Colchicine inhibits the reaction [Acetaminophen results in increased expression of ABCC4 protein]CTDPMID:18468992
Abcc4Rat(S)-naringenin multiple interactionsISOABCC4 (Homo sapiens)6480464naringenin inhibits the reaction [ABCC4 protein results in increased export of Cyclic GMP]; naringenin promotes more ...CTDPMID:16156793
Abcc4Rat1,2-dimethylhydrazine increases expressionISOAbcc4 (Mus musculus)64804641,2-Dimethylhydrazine results in increased expression of ABCC4 mRNACTDPMID:22206623
Abcc4Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of ABCC4 mRNACTDPMID:27765674
Abcc4Rat1-naphthyl isothiocyanate increases expressionISOAbcc4 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of ABCC4 mRNACTDPMID:30517764|PMID:37968239
Abcc4Rat1-naphthyl isothiocyanate multiple interactionsISOAbcc4 (Mus musculus)6480464[liquiritin co-treated with 1-Naphthylisothiocyanate] results in increased expression of ABCC4 mRNA; [obeticholic acid co-treated with more ...CTDPMID:30352267|PMID:30517764|PMID:36008890|PMID:36787806|PMID:37348807|PMID:37968239
Abcc4Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of ABCC4 proteinCTDPMID:23146761
Abcc4Rat17alpha-ethynylestradiol increases expressionISOAbcc4 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of ABCC4 proteinCTDPMID:34058177
Abcc4Rat17alpha-ethynylestradiol multiple interactionsISOAbcc4 (Mus musculus)6480464Metformin inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCC4 protein]CTDPMID:34058177
Abcc4Rat17beta-estradiol multiple interactionsISOABCC4 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in increased expression of ABCC4 mRNA; [Estradiol co-treated with Tetrachlorodibenzodioxin] more ...CTDPMID:19619570|PMID:20660070
Abcc4Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of ABCC4 mRNACTDPMID:26496021
Abcc4Rat17beta-estradiol increases expressionISOABCC4 (Homo sapiens)6480464Estradiol results in increased expression of ABCC4 mRNACTDPMID:19619570|PMID:23019147
Abcc4Rat17beta-estradiol 17-glucosiduronic acid increases transportISOABCC4 (Homo sapiens)6480464ABCC4 protein results in increased transport of estradiol-17 beta-glucuronideCTDPMID:11856762
Abcc4Rat17beta-estradiol 17-glucosiduronic acid increases exportISOABCC4 (Homo sapiens)6480464ABCC4 protein results in increased export of estradiol-17 beta-glucuronideCTDPMID:27659809
Abcc4Rat17beta-estradiol 17-glucosiduronic acid affects exportISOABCC4 (Homo sapiens)6480464ABCC4 gene SNP affects the export of estradiol-17 beta-glucuronideCTDPMID:27659809
Abcc4Rat17beta-estradiol 3-benzoate increases expressionEXP 6480464estradiol 3-benzoate results in increased expression of ABCC4 mRNA; estradiol 3-benzoate results in increased expression more ...CTDPMID:23707492
Abcc4Rat17beta-estradiol 3-benzoate multiple interactionsEXP 6480464fulvestrant inhibits the reaction [estradiol 3-benzoate results in increased expression of ABCC4 mRNA]CTDPMID:23707492
Abcc4Rat17beta-estradiol 3-benzoate decreases expressionEXP 6480464estradiol 3-benzoate results in decreased expression of ABCC4 proteinCTDPMID:23707492

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Biological Process
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Abcc4Ratbile acid and bile salt transport involved_inISOABCC4 (Homo sapiens)1624291 PMID:16282361RGDPMID:16282361
Abcc4Ratbile acid and bile salt transport involved_inIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratbile acid and bile salt transport involved_inISSUniProtKB:O154391600115GO_REF:0000024UniProtGO_REF:0000024
Abcc4RatcAMP transport involved_inISSUniProtKB:O154391600115GO_REF:0000024UniProtGO_REF:0000024
Abcc4RatcAMP transport involved_inISOABCC4 (Homo sapiens)1624291 PMID:11856762, PMID:25986174RGDPMID:11856762|PMID:25986174
Abcc4RatcAMP transport involved_inIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratchloride transmembrane transport involved_inIEAGO:00052541600115GO_REF:0000108GOCGO_REF:0000108
Abcc4Ratchloride transport involved_inIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Abcc4Ratcilium assembly acts_upstream_of_or_withinISOABCC4 (Homo sapiens)1624291 PMID:25173977RGDPMID:25173977
Abcc4Ratcilium assembly acts_upstream_of_or_withinIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratexport across plasma membrane involved_inIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratexport across plasma membrane involved_inISOABCC4 (Homo sapiens)1624291 PMID:25986174RGDPMID:25986174
Abcc4Ratglutathione transmembrane transport involved_inIEAGO:00346341600115GO_REF:0000108GOCGO_REF:0000108
Abcc4Ratguanine nucleotide transmembrane transport involved_inIEAGO:00014091600115GO_REF:0000108GOCGO_REF:0000108
Abcc4Ratleukotriene transport involved_inIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratleukotriene transport involved_inISOABCC4 (Homo sapiens)1624291 PMID:17959747RGDPMID:17959747
Abcc4Ratleukotriene transport involved_inISSUniProtKB:O154391600115GO_REF:0000024UniProtGO_REF:0000024
Abcc4Ratlipid transport involved_inIEAUniProtKB-KW:KW-04451600115GO_REF:0000043UniProtGO_REF:0000043
Abcc4Ratmonoatomic ion transmembrane transport involved_inIEAUniProtKB-KW:KW-04071600115GO_REF:0000043UniProtGO_REF:0000043
Abcc4Ratmonoatomic ion transport involved_inIEAUniProtKB-KW:KW-04061600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Original Reference(s)
Abcc4Ratapical plasma membrane located_inIEAUniProtKB-SubCell:SL-00151600115GO_REF:0000044UniProtGO_REF:0000044
Abcc4Ratapical plasma membrane located_inIEAUniProtKB:E9Q236|ensembl:ENSMUSP000000421861600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratapical plasma membrane located_inIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratapical plasma membrane located_inISOAbcc4 (Mus musculus)1624291 PMID:15314169RGDPMID:15314169
Abcc4Ratapical plasma membrane located_inISOABCC4 (Homo sapiens)1624291 PMID:11856762, PMID:25986174, PMID:31791063RGDPMID:11856762|PMID:25986174|PMID:31791063
Abcc4Ratapical plasma membrane located_inIEAARBA:ARBA000264131600115GO_REF:0000117UniProtGO_REF:0000117
Abcc4Ratbasolateral plasma membrane  IDA 2301072 RGD 
Abcc4Ratbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-00261600115GO_REF:0000044UniProtGO_REF:0000044
Abcc4Ratbasolateral plasma membrane part_ofIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratbasolateral plasma membrane located_inISOAbcc4 (Mus musculus)1624291 PMID:15314169RGDPMID:15314169
Abcc4Ratbasolateral plasma membrane is_active_inIBAMGI:2443111|PANTHER:PTN002384279|RGD:2332|RGD:620266|UniProtKB:O154391600115GO_REF:0000033GO_CentralGO_REF:0000033
Abcc4Ratbasolateral plasma membrane part_ofISOABCC4 (Homo sapiens)1624291 PMID:24130369RGDPMID:24130369
Abcc4Ratbasolateral plasma membrane located_inISOABCC4 (Homo sapiens)1624291 PMID:25986174, PMID:31791063RGDPMID:25986174|PMID:31791063
Abcc4Ratbasolateral plasma membrane located_inIEAARBA:ARBA000867151600115GO_REF:0000117UniProtGO_REF:0000117
Abcc4Ratbasolateral plasma membrane located_inIEAUniProtKB:E9Q236|ensembl:ENSMUSP000000421861600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4Ratbasolateral plasma membrane located_inIDA 2301072PMID:18619525ARUK-UCL 
Abcc4Ratchloride channel complex part_ofIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Abcc4Ratcilium NOT|located_inISOAbcc4 (Mus musculus)1624291 PMID:25173977RGDPMID:25173977
Abcc4Ratearly endosome membrane located_inIEAUniProtKB-SubCell:SL-00931600115GO_REF:0000044UniProtGO_REF:0000044
Abcc4Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
Abcc4RatABC-type bile acid transporter activity enablesISSUniProtKB:O154391600115GO_REF:0000024UniProtGO_REF:0000024
Abcc4RatABC-type bile acid transporter activity enablesISOABCC4 (Homo sapiens)1624291 PMID:16282361RGDPMID:16282361
Abcc4RatABC-type bile acid transporter activity enablesIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4RatABC-type glutathione S-conjugate transporter activity enablesISSUniProtKB:O154391600115GO_REF:0000024UniProtGO_REF:0000024
Abcc4RatABC-type glutathione S-conjugate transporter activity enablesIEAEC:7.6.2.31600115GO_REF:0000003UniProtGO_REF:0000003
Abcc4RatABC-type glutathione S-conjugate transporter activity enablesISOABCC4 (Homo sapiens)1624291 PMID:17959747RGDPMID:17959747
Abcc4RatABC-type glutathione S-conjugate transporter activity enablesIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4RatABC-type transporter activity enablesIEAInterPro:IPR0115271600115GO_REF:0000002InterProGO_REF:0000002
Abcc4RatABC-type transporter activity enablesIBAFB:FBgn0032026|FB:FBgn0038740|MGI:102676|MGI:1351644|PANTHER:PTN009085477|PomBase:SPAC3F10.11c|PomBase:SPBC359.05|RGD:2366|RGD:3112|RGD:620268|RGD:71101|SGD:S000002542|SGD:S000003513|TAIR:locus:2061559|TAIR:locus:2081755|TAIR:locus:2090029|TAIR:locus:2204202|UniProtKB:O15438|UniProtKB:O15439|UniProtKB:O15440|UniProtKB:O95255|UniProtKB:P33527|UniProtKB:Q5T3U5|UniProtKB:Q92887|UniProtKB:Q96J66|WB:WBGene00003411|ZFIN:ZDB-GENE-030616-5111600115GO_REF:0000033GO_CentralGO_REF:0000033
Abcc4RatABC-type xenobiotic transporter activity enablesIEAEC:7.6.2.21600115GO_REF:0000003UniProtGO_REF:0000003
Abcc4RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Abcc4RatATP binding enablesIEAInterPro:IPR003439|InterPro:IPR011527|InterPro:IPR017871|InterPro:IPR0366401600115GO_REF:0000002InterProGO_REF:0000002
Abcc4RatATP binding enablesIEAInterPro:IPR003439|InterPro:IPR011527|InterPro:IPR017871|InterPro:IPR030240|InterPro:IPR0366401600115GO_REF:0000002InterProGO_REF:0000002
Abcc4RatATP hydrolysis activity enablesIEAInterPro:IPR003439|InterPro:IPR0178711600115GO_REF:0000002InterProGO_REF:0000002
Abcc4RatATPase-coupled transmembrane transporter activity enablesISSUniProtKB:O154391600115GO_REF:0000024UniProtGO_REF:0000024
Abcc4RatATPase-coupled transmembrane transporter activity enablesIEAUniProtKB:O15439|ensembl:ENSP000004946091600115GO_REF:0000107EnsemblGO_REF:0000107
Abcc4RatATPase-coupled transmembrane transporter activity enablesIEAInterPro:IPR0302401600115GO_REF:0000002InterProGO_REF:0000002
Abcc4RatATPase-coupled transmembrane transporter activity enablesISOABCC4 (Homo sapiens)1624291 PMID:15364914, PMID:15454390RGDPMID:15364914|PMID:15454390
Abcc4Ratchloride channel activity enablesIEAUniProtKB-KW:KW-08691600115GO_REF:0000043UniProtGO_REF:0000043
Abcc4Ratchloride channel activity enablesIEAInterPro:IPR0091471600115GO_REF:0000002InterProGO_REF:0000002
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RGD Manual Annotations


  
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Original Reference(s)
Abcc4Ratmultidrug resistance-associated protein mediated transport pathway  ISS 1358123 RGD 
Abcc4Ratparacetamol pharmacokinetics pathway   TAS 8552693 RGD 

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Abcc4Ratbile acid transport pathway  IEA 6907045 KEGGrno:04976

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#
Reference Title
Reference Citation
1. Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility. Chen C and Klaassen CD, Biochem Biophys Res Commun. 2004 Apr 23;317(1):46-53.
2. Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat. Denk GU, etal., J Hepatol. 2004 Apr;40(4):585-91.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Transport of xenobiotics across the blood-brain barrier. Hagenbuch B, etal., News Physiol Sci 2002 Dec;17:231-4.
5. Exploration of Hepatoprotective Effect of Gentiopicroside on Alpha-Naphthylisothiocyanate-Induced Cholestatic Liver Injury in Rats by Comprehensive Proteomic and Metabolomic Signatures. Han H, etal., Cell Physiol Biochem. 2018;49(4):1304-1319. doi: 10.1159/000493409. Epub 2018 Sep 17.
6. Metabolism and disposition of acetaminophen: recent advances in relation to hepatotoxicity and diagnosis. McGill MR and Jaeschke H, Pharm Res. 2013 Sep;30(9):2174-87. doi: 10.1007/s11095-013-1007-6. Epub 2013 Mar 6.
7. Induction of drug metabolism enzymes and transporters by oltipraz in rats. Merrell MD, etal., J Biochem Mol Toxicol. 2008;22(2):128-35.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Change of drug excretory pathway by CCl4-induced liver dysfunction in rat. Okumura H, etal., Biochem Pharmacol. 2007 Aug 1;74(3):488-95. Epub 2007 May 3.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Comprehensive gene review and curation RGD comprehensive gene curation
16. Subcellular localization of transporters along the rat blood-brain barrier and blood-cerebral-spinal fluid barrier by in vivo biotinylation. Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
17. Multidrug resistance-associated protein 4 regulates cAMP-dependent signaling pathways and controls human and rat SMC proliferation. Sassi Y, etal., J Clin Invest. 2008 Aug;118(8):2747-57.
18. The MRP4/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP. van Aubel RA, etal., J Am Soc Nephrol 2002 Mar;13(3):595-603.
19. Modulation of transport and metabolism of bile acids and bilirubin by chlorogenic acid against hepatotoxicity and cholestasis in bile duct ligation rats: involvement of SIRT1-mediated deacetylation of FXR and PGC-1α. Zhu L, etal., J Hepatobiliary Pancreat Sci. 2018 Mar;25(3):195-205. doi: 10.1002/jhbp.537.
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PMID:12883481   PMID:15297306   PMID:15504935   PMID:19671067   PMID:19946888   PMID:21167233   PMID:21237168   PMID:23306951   PMID:24130369   PMID:25173977   PMID:25986174   PMID:26244301  
PMID:26458556   PMID:28298215   PMID:30995593   PMID:33132311   PMID:35269592  



Abcc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr815101,948,387 - 102,182,912 (-)NCBIGRCr8
GRCr8 Ensembl15101,949,433 - 102,181,375 (-)EnsemblGRCr8 Ensembl
mRatBN7.21595,541,186 - 95,774,898 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1595,542,315 - 95,774,283 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1599,449,698 - 99,683,523 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.015100,581,669 - 100,815,501 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01597,510,336 - 97,744,179 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.015103,695,415 - 103,927,980 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.015107,127,408 - 107,356,997 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.415103,384,848 - 103,611,238 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1594,392,176 - 94,624,412 (-)NCBICelera
RGSC_v3.115103,416,404 - 103,417,006 (-)NCBI
Cytogenetic Map15q24NCBI
ABCC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381395,019,835 - 95,301,451 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1395,019,835 - 95,301,475 (-)EnsemblGRCh38hg38GRCh38
GRCh371395,672,089 - 95,953,705 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361394,470,084 - 94,751,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 341394,470,089 - 94,751,684NCBI
Celera1376,520,037 - 76,801,492 (-)NCBICelera
Cytogenetic Map13q32.1NCBI
HuRef1376,269,792 - 76,551,747 (-)NCBIHuRef
CHM1_11395,641,739 - 95,923,875 (-)NCBICHM1_1
T2T-CHM13v2.01394,223,430 - 94,506,029 (-)NCBIT2T-CHM13v2.0
Abcc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3914118,720,104 - 118,945,475 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl14118,720,104 - 118,943,631 (-)EnsemblGRCm39 Ensembl
GRCm3814118,482,692 - 118,707,856 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl14118,482,692 - 118,706,219 (-)EnsemblGRCm38mm10GRCm38
MGSCv3714118,881,914 - 119,105,441 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3614117,366,402 - 117,589,897 (-)NCBIMGSCv36mm8
Celera14117,040,185 - 117,267,837 (-)NCBICelera
Cytogenetic Map14E4NCBI
cM Map1462.24NCBI
Abcc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540414,700,808 - 14,928,617 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540414,700,808 - 14,927,944 (+)NCBIChiLan1.0ChiLan1.0
ABCC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21496,549,596 - 96,832,300 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11395,218,532 - 95,500,954 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01376,193,929 - 76,476,119 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11395,349,915 - 95,596,193 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1395,349,915 - 95,582,058 (-)Ensemblpanpan1.1panPan2
ABCC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12245,767,033 - 46,013,577 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2245,765,835 - 46,013,505 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2245,552,541 - 45,797,861 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02246,197,405 - 46,443,625 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2246,196,166 - 46,443,705 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12245,859,950 - 46,105,864 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02245,893,451 - 46,139,289 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02245,899,895 - 46,145,744 (-)NCBIUU_Cfam_GSD_1.0
Abcc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945181,327,558 - 181,555,006 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647214,397,222 - 14,624,648 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647214,396,986 - 14,624,597 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100738425
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11164,861,069 - 64,996,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21171,819,382 - 71,859,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABCC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1373,821,887 - 74,106,617 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl373,821,134 - 74,106,579 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604630,211,012 - 30,527,853 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abcc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248791,811,651 - 2,060,099 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248791,811,686 - 2,060,221 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Abcc4
1516 total Variants

Predicted Target Of
Summary Value
Count of predictions:484
Count of miRNA genes:153
Interacting mature miRNAs:165
Transcripts:ENSRNOT00000013366, ENSRNOT00000031036
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 15 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
731177Uae26Urinary albumin excretion QTL 262.40.025urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1567588667101769107Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
1549844Bss7Bone structure and strength QTL 76.4femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1575788062101769107Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1568327165100062518Rat
1300118Bp190Blood pressure QTL 1902.94arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)158226252098288169Rat
70155Gcs1Gastric cancer susceptibility QTL13.8stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)1576306099101769107Rat
1300120Kidm7Kidney mass QTL 73.55kidney mass (VT:0002707)left kidney wet weight to body weight ratio (CMO:0001954)158226252098288169Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat

1 to 10 of 15 rows
RH143776  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,709,760 - 95,709,909 (+)MAPPERmRatBN7.2
Rnor_6.015103,863,409 - 103,863,557NCBIRnor6.0
Rnor_5.015107,293,048 - 107,293,196UniSTSRnor5.0
RGSC_v3.415103,546,131 - 103,546,279UniSTSRGSC3.4
Celera1594,559,460 - 94,559,608UniSTS
RH 3.4 Map15651.3UniSTS
Cytogenetic Map15q24UniSTS
BI286235  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,775,474 - 95,775,679 (+)MAPPERmRatBN7.2
Rnor_6.015103,928,620 - 103,928,824NCBIRnor6.0
Rnor_5.015107,358,025 - 107,358,229UniSTSRnor5.0
RGSC_v3.415103,612,519 - 103,612,723UniSTSRGSC3.4
Celera1594,625,559 - 94,625,763UniSTS
RH 3.4 Map15650.3UniSTS
Cytogenetic Map15q24UniSTS
AU047861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,740,080 - 95,740,374 (+)MAPPERmRatBN7.2
Rnor_6.015103,893,726 - 103,894,017NCBIRnor6.0
Rnor_5.015107,323,365 - 107,323,656UniSTSRnor5.0
RGSC_v3.415103,576,447 - 103,576,738UniSTSRGSC3.4
Celera1594,589,955 - 94,590,246UniSTS
Cytogenetic Map15q24UniSTS
RH141533  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21595,542,403 - 95,542,613 (+)MAPPERmRatBN7.2
Rnor_6.015103,696,633 - 103,696,842NCBIRnor6.0
Rnor_5.015107,127,515 - 107,127,724UniSTSRnor5.0
RGSC_v3.415103,384,955 - 103,385,164UniSTSRGSC3.4
Celera1594,392,283 - 94,392,492UniSTS
RH 3.4 Map15648.7UniSTS
Cytogenetic Map15q24UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000013366   ⟹   ENSRNOP00000013366
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,433 - 102,181,364 (-)Ensembl
mRatBN7.2 Ensembl1595,542,315 - 95,774,272 (-)Ensembl
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000031036   ⟹   ENSRNOP00000033826
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,433 - 102,181,364 (-)Ensembl
mRatBN7.2 Ensembl1595,542,315 - 95,774,272 (-)Ensembl
Rnor_6.0 Ensembl15103,696,557 - 103,927,592 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100006   ⟹   ENSRNOP00000076836
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,917 - 102,181,375 (-)Ensembl
mRatBN7.2 Ensembl1595,542,799 - 95,774,283 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109236   ⟹   ENSRNOP00000076917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,917 - 102,181,375 (-)Ensembl
mRatBN7.2 Ensembl1595,542,799 - 95,774,283 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117189   ⟹   ENSRNOP00000089564
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,433 - 102,128,294 (-)Ensembl
mRatBN7.2 Ensembl1595,542,315 - 95,721,172 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000128450   ⟹   ENSRNOP00000104561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl15101,949,917 - 102,181,375 (-)Ensembl
RefSeq Acc Id: NM_133411   ⟹   NP_596902
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,949,415 - 102,181,364 (-)NCBI
mRatBN7.21595,542,297 - 95,774,272 (-)NCBI
Rnor_6.015103,696,526 - 103,927,592 (-)NCBI
Rnor_5.015107,127,408 - 107,356,997 (-)NCBI
RGSC_v3.415103,384,848 - 103,611,238 (-)RGD
Celera1594,392,176 - 94,624,412 (-)RGD
Sequence:
RefSeq Acc Id: XM_039092966   ⟹   XP_038948894
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,948,387 - 102,182,912 (-)NCBI
mRatBN7.21595,541,186 - 95,774,898 (-)NCBI
RefSeq Acc Id: XM_039092967   ⟹   XP_038948895
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,948,387 - 102,182,912 (-)NCBI
mRatBN7.21595,541,186 - 95,774,898 (-)NCBI
RefSeq Acc Id: XM_063273922   ⟹   XP_063129992
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,948,387 - 102,128,722 (-)NCBI
RefSeq Acc Id: XM_063273923   ⟹   XP_063129993
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,990,866 - 102,182,912 (-)NCBI
RefSeq Acc Id: XM_063273924   ⟹   XP_063129994
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815102,056,959 - 102,182,912 (-)NCBI
RefSeq Acc Id: XM_063273925   ⟹   XP_063129995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr815101,948,387 - 102,075,178 (-)NCBI
1 to 5 of 13 rows
1 to 5 of 13 rows
RefSeq Acc Id: NP_596902   ⟸   NM_133411
- UniProtKB: F1M3J4 (UniProtKB/Swiss-Prot),   Q6QMG6 (UniProtKB/TrEMBL),   Q59DL1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000033826   ⟸   ENSRNOT00000031036
Ensembl Acc Id: ENSRNOP00000013366   ⟸   ENSRNOT00000013366
RefSeq Acc Id: XP_038948895   ⟸   XM_039092967
- Peptide Label: isoform X2
- UniProtKB: Q6QMG6 (UniProtKB/Swiss-Prot),   F1M3J4 (UniProtKB/Swiss-Prot),   Q59DL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038948894   ⟸   XM_039092966
- Peptide Label: isoform X1
- UniProtKB: Q6QMG6 (UniProtKB/Swiss-Prot),   F1M3J4 (UniProtKB/Swiss-Prot),   A0A8I5YBX7 (UniProtKB/TrEMBL),   Q59DL1 (UniProtKB/TrEMBL)
ABC transmembrane type-1   ABC transporter

Name Modeler Protein Id AA Range Protein Structure
AF-F1M3J4-F1-model_v2 AlphaFold F1M3J4 1-1325 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 42 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-12442 BioCyc
Ensembl Genes ENSRNOG00000010064 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000031036 ENTREZGENE
  ENSRNOT00000100006 ENTREZGENE
  ENSRNOT00000117189 ENTREZGENE
Gene3D-CATH 1.20.1560.10 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
InterPro AAA+_ATPase UniProtKB/Swiss-Prot
  ABC1_TM_dom UniProtKB/Swiss-Prot
  ABC1_TM_sf UniProtKB/Swiss-Prot
  ABC_transporter-like UniProtKB/Swiss-Prot
  ABC_transporter_C UniProtKB/Swiss-Prot
  ABC_transporter_CS UniProtKB/Swiss-Prot
  ABCC4 UniProtKB/Swiss-Prot
  ABCC4_TMD2 UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
KEGG Report rno:170924 UniProtKB/Swiss-Prot
NCBI Gene 170924 ENTREZGENE
PANTHER ATP-BINDING CASSETTE SUB-FAMILY C UniProtKB/Swiss-Prot
  PTHR24223:SF357 UniProtKB/Swiss-Prot
Pfam ABC_membrane UniProtKB/Swiss-Prot
  ABC_tran UniProtKB/Swiss-Prot
PharmGKB ABCC4 RGD
PhenoGen Abcc4 PhenoGen
PROSITE ABC_TM1F UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_1 UniProtKB/Swiss-Prot
  ABC_TRANSPORTER_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010064 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
  SSF90123 UniProtKB/Swiss-Prot
UniProt A0A8I5Y0H3_RAT UniProtKB/TrEMBL
  A0A8I5YBX7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A923 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UKX0_RAT UniProtKB/TrEMBL
  A6HUG6 ENTREZGENE, UniProtKB/TrEMBL
  F1LR52_RAT UniProtKB/TrEMBL
  F1M3J4 ENTREZGENE, UniProtKB/Swiss-Prot
  Q59DL1 ENTREZGENE, UniProtKB/TrEMBL
  Q6QMG5_RAT UniProtKB/TrEMBL
1 to 40 of 42 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-09 Abcc4  ATP binding cassette subfamily C member 4  Abcc4  ATP-binding cassette, subfamily C (CFTR/MRP), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 Abcc4  ATP-binding cassette, subfamily C (CFTR/MRP), member 4  RGD1565953  similar to multidrug resistance-associated protein 4  Data merged from RGD:1565953 737654 PROVISIONAL
2010-11-16 Abcc4  ATP-binding cassette, subfamily C (CFTR/MRP), member 4  Abcc4  ATP-binding cassette, sub-family C (CFTR/MRP), member 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1565953  similar to multidrug resistance-associated protein 4   RGD1565953_predicted  similar to multidrug resistance-associated protein 4 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1565953_predicted  similar to multidrug resistance-associated protein 4 (predicted)  LOC306166  similar to multidrug resistance-associated protein 4  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC306166  similar to multidrug resistance-associated protein 4      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-01-20 Abcc4  ATP-binding cassette, sub-family C (CFTR/MRP), member 4      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Abcc4  ATP-binding cassette, sub-family C (CFTR/MRP), member 4      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in kidney