Pik3c2g (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma) - Rat Genome Database

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Gene: Pik3c2g (phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma) Rattus norvegicus
Analyze
Symbol: Pik3c2g
Name: phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
RGD ID: 620231
Description: Enables 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in phosphatidylinositol-3-phosphate biosynthetic process. Located in nuclear envelope. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PIK3C2G (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma); PARTICIPATES IN inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LRRG00132; phosphatidylinositol 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide; phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing gamma polypeptide; phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit gamma; phosphoinositide 3-Kinase-C2-gamma; phosphoinositide-3-kinase, class 2, gamma polypeptide; PI3K-C2-gamma; PI3K-C2gamma; ptdIns-3-kinase C2 gamma; ptdIns-3-kinase C2 subunit gamma
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84174,215,527 - 174,583,378 (+)NCBIGRCr8
mRatBN7.24172,483,752 - 172,851,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4172,484,345 - 172,850,544 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4178,779,339 - 179,145,536 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04174,563,498 - 174,929,713 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04173,184,038 - 173,550,261 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04173,732,196 - 174,102,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4173,732,248 - 174,102,496 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04237,973,381 - 238,271,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04238,344,297 - 238,356,116 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44176,712,201 - 177,074,095 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14176,957,324 - 177,319,218 (+)NCBI
Celera4161,042,817 - 161,401,470 (+)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
Pik3c2gRattype 2 diabetes mellitus susceptibilityISOPIK3C2G (Homo sapiens)13506796DNA:SNP:cds:437C>T(human)RGD 
Object Symbol
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Original Reference(s)
Pik3c2gRatcoronary artery disease  ISOPIK3C2G (Homo sapiens)8554872ClinVar Annotator: match by term: Premature coronary artery atherosclerosisClinVarPMID:25741868
Pik3c2gRatspermatogenic failure 17  ISOPIK3C2G (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Pik3c2gRatTracheoesophageal Fistula  ISOPIK3C2G (Homo sapiens)8554872ClinVar Annotator: match by term: Tracheoesophageal fistulaClinVarPMID:32641753

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Original Reference(s)
Pik3c2gRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of PIK3C2G mRNA]CTDPMID:31150632
Pik3c2gRat1,2-dichloroethane increases expressionISOPik3c2g (Mus musculus)6480464ethylene dichloride results in increased expression of PIK3C2G mRNACTDPMID:28960355
Pik3c2gRat1,2-dimethylhydrazine affects expressionISOPik3c2g (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of PIK3C2G mRNACTDPMID:22206623
Pik3c2gRat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of PIK3C2G mRNACTDPMID:32145629
Pik3c2gRat17beta-estradiol increases expressionISOPik3c2g (Mus musculus)6480464Estradiol results in increased expression of PIK3C2G mRNACTDPMID:39298647
Pik3c2gRat17beta-estradiol 3-benzoate increases methylationEXP 6480464estradiol 3-benzoate results in increased methylation of PIK3C2G promoterCTDPMID:27415467
Pik3c2gRat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PIK3C2G mRNACTDPMID:22298810 and PMID:32109520
Pik3c2gRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PIK3C2G mRNACTDPMID:18796159 more ...
Pik3c2gRat3,3',4,4',5-pentachlorobiphenyl decreases expressionEXP 64804643 more ...CTDPMID:20959002
Pik3c2gRat4,4'-sulfonyldiphenol affects methylationISOPIK3C2G (Homo sapiens)6480464bisphenol S affects the methylation of PIK3C2G geneCTDPMID:31601247
Pik3c2gRatacetamide decreases expressionEXP 6480464acetamide results in decreased expression of PIK3C2G mRNACTDPMID:31881176
Pik3c2gRataflatoxin B1 affects expressionISOPIK3C2G (Homo sapiens)6480464Aflatoxin B1 affects the expression of PIK3C2G proteinCTDPMID:20106945
Pik3c2gRataflatoxin B1 decreases expressionISOPIK3C2G (Homo sapiens)6480464Aflatoxin B1 results in decreased expression of PIK3C2G mRNACTDPMID:22100608 and PMID:27153756
Pik3c2gRatAflatoxin B2 alpha increases methylationISOPIK3C2G (Homo sapiens)6480464aflatoxin B2 results in increased methylation of PIK3C2G intronCTDPMID:30157460
Pik3c2gRatammonium chloride affects expressionEXP 6480464Ammonium Chloride affects the expression of PIK3C2G mRNACTDPMID:16483693
Pik3c2gRatarsane affects methylationISOPIK3C2G (Homo sapiens)6480464Arsenic affects the methylation of PIK3C2G geneCTDPMID:25304211
Pik3c2gRatarsenic atom affects methylationISOPIK3C2G (Homo sapiens)6480464Arsenic affects the methylation of PIK3C2G geneCTDPMID:25304211
Pik3c2gRatatazanavir sulfate multiple interactionsISOPIK3C2G (Homo sapiens)6480464[Atazanavir Sulfate co-treated with Glycochenodeoxycholic Acid co-treated with Deoxycholic Acid co-treated with Chenodeoxycholic Acid co-treated with Glycodeoxycholic Acid co-treated with Glycocholic Acid] results in decreased expression of PIK3C2G mRNACTDPMID:32152650
Pik3c2gRatatazanavir sulfate decreases expressionISOPIK3C2G (Homo sapiens)6480464Atazanavir Sulfate results in decreased expression of PIK3C2G mRNACTDPMID:32152650
Pik3c2gRatbenzo[a]pyrene increases methylationISOPIK3C2G (Homo sapiens)6480464Benzo(a)pyrene results in increased methylation of PIK3C2G 5' UTRCTDPMID:27901495

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Biological Process
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Original Reference(s)
Pik3c2gRatcell migration involved_inIBAFB:FBgn0015279 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c2gRatchemotaxis involved_inISOPik3c2g (Mus musculus)1624291 PMID:20536348RGDPMID:20536348
Pik3c2gRatchemotaxis involved_inIEAUniProtKB-KW:KW-01451600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c2gRatlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c2gRatmodulation by host of viral process involved_inIEAUniProtKB:O75747 and ensembl:ENSP000004453811600115GO_REF:0000107EnsemblGO_REF:0000107
Pik3c2gRatphosphatidylinositol 3-kinase/protein kinase B signal transduction involved_inIBAFB:FBgn0015279 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c2gRatphosphatidylinositol phosphate biosynthetic process involved_inIEAInterPro:IPR0154331600115GO_REF:0000002InterProGO_REF:0000002
Pik3c2gRatphosphatidylinositol-3-phosphate biosynthetic process involved_inIDA 729517PMID:9516481UniProt 
Pik3c2gRatphosphatidylinositol-3-phosphate biosynthetic process involved_inISOPik3c2g (Mus musculus)1624291 PMID:9514948RGDPMID:9514948
Pik3c2gRatphosphatidylinositol-3-phosphate biosynthetic process involved_inIBAMGI:1203729 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c2gRatphosphatidylinositol-mediated signaling involved_inIBAPANTHER:PTN000005673 and dictyBase:DDB_G02787271600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
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Original Reference(s)
Pik3c2gRatcytoplasm is_active_inIBAFB:FBgn0004373 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c2gRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c2gRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Pik3c2gRatmembrane located_inISOPik3c2g (Mus musculus)1624291 PMID:9514948RGDPMID:9514948
Pik3c2gRatnuclear envelope  IDA 729517 RGD 
Pik3c2gRatplasma membrane is_active_inIBAPANTHER:PTN000005674 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 17 of 17 rows

  
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Original Reference(s)
Pik3c2gRat1-phosphatidylinositol 4-kinase activity NOT|enablesIDA 729517PMID:9516481UniProt 
Pik3c2gRat1-phosphatidylinositol-3-kinase activity enablesIDA 729517PMID:9516481UniProt 
Pik3c2gRat1-phosphatidylinositol-3-kinase activity enablesIBAFB:FBgn0015278 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c2gRat1-phosphatidylinositol-3-kinase activity enablesISOPik3c2g (Mus musculus)1624291 PMID:9514948RGDPMID:9514948
Pik3c2gRat1-phosphatidylinositol-3-kinase activity enablesIEARHEA:127091600115GO_REF:0000116RHEAGO_REF:0000116
Pik3c2gRat1-phosphatidylinositol-4-phosphate 3-kinase activity  IDA 729517 RGD 
Pik3c2gRat1-phosphatidylinositol-4-phosphate 3-kinase activity enablesIEARHEA:183731600115GO_REF:0000116RHEAGO_REF:0000116
Pik3c2gRat1-phosphatidylinositol-4-phosphate 3-kinase activity enablesIBAFB:FBgn0015278 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pik3c2gRat1-phosphatidylinositol-4-phosphate 3-kinase activity enablesIEAEC:2.7.1.1541600115GO_REF:0000003UniProtGO_REF:0000003
Pik3c2gRat1-phosphatidylinositol-4-phosphate 3-kinase activity enablesISOPik3c2g (Mus musculus)1624291 PMID:9514948RGDPMID:9514948
Pik3c2gRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c2gRatkinase activity enablesIEAInterPro:IPR0189361600115GO_REF:0000002InterProGO_REF:0000002
Pik3c2gRatkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c2gRatnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Pik3c2gRatphosphatidylinositol binding enablesIEAInterPro:IPR001683 and InterPro:IPR0368711600115GO_REF:0000002InterProGO_REF:0000002
Pik3c2gRatphosphatidylinositol kinase activity enablesIEAARBA:ARBA000334941600115GO_REF:0000117UniProtGO_REF:0000117
Pik3c2gRattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
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Imported Annotations - KEGG (archival)

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Original Reference(s)
Pik3c2gRatinositol phosphate metabolic pathway  IEA 6907045 KEGGrno:00562
Pik3c2gRatphosphatidylinositol 3-kinase signaling pathway  IEA 6907045 KEGGrno:04070

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#
Reference Title
Reference Citation
1. Association of the PIK3C2G gene polymorphisms with type 2 DM in a Japanese population. Daimon M, etal., Biochem Biophys Res Commun. 2008 Jan 18;365(3):466-71. doi: 10.1016/j.bbrc.2007.10.180. Epub 2007 Nov 6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. A novel class II phosphoinositide 3-kinase predominantly expressed in the liver and its enhanced expression during liver regeneration. Ono F, etal., J Biol Chem 1998 Mar 27;273(13):7731-6.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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PMID:12464394   PMID:12482897   PMID:15362046   PMID:19376974   PMID:20536348  



Pik3c2g
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84174,215,527 - 174,583,378 (+)NCBIGRCr8
mRatBN7.24172,483,752 - 172,851,623 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4172,484,345 - 172,850,544 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4178,779,339 - 179,145,536 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04174,563,498 - 174,929,713 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04173,184,038 - 173,550,261 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04173,732,196 - 174,102,502 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4173,732,248 - 174,102,496 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04237,973,381 - 238,271,814 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.04238,344,297 - 238,356,116 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44176,712,201 - 177,074,095 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14176,957,324 - 177,319,218 (+)NCBI
Celera4161,042,817 - 161,401,470 (+)NCBICelera
Cytogenetic Map4q44NCBI
PIK3C2G
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381218,242,961 - 18,726,817 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1218,242,961 - 18,648,416 (+)EnsemblGRCh38hg38GRCh38
GRCh371218,414,452 - 18,801,350 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361218,305,741 - 18,692,617 (+)NCBINCBI36Build 36hg18NCBI36
Build 341218,305,740 - 18,692,615NCBI
Celera1223,559,670 - 23,946,872 (+)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1218,182,567 - 18,569,771 (+)NCBIHuRef
CHM1_11218,379,684 - 18,766,393 (+)NCBICHM1_1
T2T-CHM13v2.01218,118,895 - 18,602,723 (+)NCBIT2T-CHM13v2.0
Pik3c2g
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396139,591,070 - 139,915,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6139,564,219 - 139,915,010 (+)EnsemblGRCm39 Ensembl
GRCm386139,614,072 - 139,969,284 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6139,587,221 - 139,969,284 (+)EnsemblGRCm38mm10GRCm38
MGSCv376139,664,380 - 139,917,805 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv376139,562,593 - 139,605,759 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366139,678,267 - 139,931,692 (+)NCBIMGSCv36mm8
Celera6142,714,228 - 143,033,452 (+)NCBICelera
Cytogenetic Map6G2NCBI
cM Map669.7NCBI
Pik3c2g
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541314,454,377 - 14,764,558 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541314,454,376 - 14,764,323 (+)NCBIChiLan1.0ChiLan1.0
PIK3C2G
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21023,702,676 - 24,088,671 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11223,699,436 - 24,085,421 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01218,258,487 - 18,644,464 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11218,664,539 - 19,030,778 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1218,664,631 - 19,030,493 (+)Ensemblpanpan1.1panPan2
PIK3C2G
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12728,446,629 - 28,818,198 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2728,424,899 - 28,796,902 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2717,634,256 - 18,004,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02728,777,707 - 29,148,879 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2728,777,942 - 29,120,607 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12728,624,760 - 28,982,990 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02728,617,093 - 28,982,011 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02717,346,838 - 17,712,725 (+)NCBIUU_Cfam_GSD_1.0
Pik3c2g
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494589,681,373 - 90,001,143 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365487,604,404 - 7,856,872 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365487,604,272 - 7,923,984 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3C2G
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl554,474,622 - 54,849,512 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1554,474,623 - 54,849,520 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2557,747,735 - 58,146,257 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3C2G
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11118,099,328 - 18,500,030 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1118,118,717 - 18,499,985 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606916,715,340 - 17,100,145 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pik3c2g
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475219,876,933 - 20,212,907 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475219,878,095 - 20,212,872 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Pik3c2g
2752 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
4 174036106 174036107 A G snv FHH/EurMcwi (MCW), FHH/EurMcwi (2019), FHH/EurMcwi (RGD), FHL/EurMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:16
Count of miRNA genes:15
Interacting mature miRNAs:16
Transcripts:ENSRNOT00000041499
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat

1 to 10 of 19 rows
D4Got275  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr84174,405,942 - 174,406,184 (+)Marker Load Pipeline
mRatBN7.24172,674,773 - 172,675,015 (+)MAPPERmRatBN7.2
Rnor_6.04173,928,221 - 173,928,462NCBIRnor6.0
Rnor_5.04238,164,878 - 238,165,119UniSTSRnor5.0
RGSC_v3.44176,903,911 - 176,904,152UniSTSRGSC3.4
Celera4161,228,714 - 161,228,955UniSTS
Cytogenetic Map4q44UniSTS
BE113549  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24172,486,558 - 172,486,715 (+)MAPPERmRatBN7.2
Rnor_6.04173,734,462 - 173,734,618NCBIRnor6.0
Rnor_5.04237,975,595 - 237,975,751UniSTSRnor5.0
RGSC_v3.44176,714,415 - 176,714,571UniSTSRGSC3.4
Celera4161,045,031 - 161,045,187UniSTS
RH 3.4 Map41031.7UniSTS
Cytogenetic Map4q44UniSTS
RH137861  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24172,522,615 - 172,522,754 (+)MAPPERmRatBN7.2
Rnor_6.04173,770,513 - 173,770,651NCBIRnor6.0
Rnor_5.04238,011,653 - 238,011,791UniSTSRnor5.0
RGSC_v3.44176,750,473 - 176,750,611UniSTSRGSC3.4
Celera4161,081,066 - 161,081,204UniSTS
RH 3.4 Map41033.6UniSTS
Cytogenetic Map4q44UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 39 92 86 90 59 25 59 6 196 81 77 39 58 31



Ensembl Acc Id: ENSRNOT00000041499   ⟹   ENSRNOP00000043855
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4172,484,345 - 172,850,544 (+)Ensembl
Rnor_6.0 Ensembl4173,732,248 - 174,102,496 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000078963   ⟹   ENSRNOP00000071128
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4172,722,676 - 172,737,935 (+)Ensembl
RefSeq Acc Id: NM_053923   ⟹   NP_446375
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84174,215,527 - 174,581,708 (+)NCBI
mRatBN7.24172,484,345 - 172,850,547 (+)NCBI
Rnor_6.04173,732,248 - 174,102,499 (+)NCBI
Rnor_5.04237,973,381 - 238,271,814 (+)NCBI
Rnor_5.04238,344,297 - 238,356,116 (+)NCBI
RGSC_v3.44176,712,201 - 177,074,095 (+)RGD
Celera4161,042,817 - 161,401,470 (+)RGD
Sequence:
RefSeq Acc Id: XM_039106948   ⟹   XP_038962876
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84174,252,810 - 174,583,378 (+)NCBI
mRatBN7.24172,483,758 - 172,851,623 (+)NCBI
RefSeq Acc Id: XR_005503143
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84174,252,810 - 174,371,605 (+)NCBI
mRatBN7.24172,483,752 - 172,640,505 (+)NCBI
RefSeq Acc Id: XR_010065609
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84174,252,810 - 174,371,677 (+)NCBI
Protein RefSeqs NP_446375 (Get FASTA)   NCBI Sequence Viewer  
  XP_038962876 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAS66223 (Get FASTA)   NCBI Sequence Viewer  
  BAA25634 (Get FASTA)   NCBI Sequence Viewer  
  EDM01564 (Get FASTA)   NCBI Sequence Viewer  
  EDM01565 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000043855
GenBank Protein O70173 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_446375   ⟸   NM_053923
- UniProtKB: O70173 (UniProtKB/Swiss-Prot),   D3ZE56 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000043855   ⟸   ENSRNOT00000041499
RefSeq Acc Id: XP_038962876   ⟸   XM_039106948
- Peptide Label: isoform X1
- UniProtKB: O70173 (UniProtKB/Swiss-Prot),   D3ZE56 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000071128   ⟸   ENSRNOT00000078963
C2   C2 PI3K-type   PI3K-RBD   PI3K/PI4K catalytic   PIK helical   PX   Reverse transcriptase

Name Modeler Protein Id AA Range Protein Structure
AF-O70173-F1-model_v2 AlphaFold O70173 1-1505 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693476
Promoter ID:EPDNEW_R3999
Type:initiation region
Name:Pik3c2g_1
Description:phosphatidylinositol-4-phosphate 3-kinase, catalytic subunittype 2 gamma
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.04173,732,235 - 173,732,295EPDNEW


1 to 40 of 59 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-42549 BioCyc
Ensembl Genes ENSRNOG00000034228 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000041499 ENTREZGENE
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot
  1.25.40.70 UniProtKB/Swiss-Prot
  2.60.40.150 UniProtKB/Swiss-Prot
  3.30.1520.10 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1 UniProtKB/Swiss-Prot
  Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4 UniProtKB/Swiss-Prot
InterPro ARM-type_fold UniProtKB/Swiss-Prot
  C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Phox UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot
  PI3/4_kinase_CS UniProtKB/Swiss-Prot
  PI3K_accessory_sf UniProtKB/Swiss-Prot
  PI3K_C2_dom UniProtKB/Swiss-Prot
  PI3K_Ras-bd_dom UniProtKB/Swiss-Prot
  PI_Kinase UniProtKB/Swiss-Prot
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
  PX_dom_sf UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot
KEGG Report rno:116720 UniProtKB/Swiss-Prot
NCBI Gene 116720 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 4-PHOSPHATE 3-KINASE C2 DOMAIN-CONTAINING SUBUNIT GAMMA UniProtKB/Swiss-Prot
  PTHR10048 UniProtKB/Swiss-Prot
Pfam PF00168 UniProtKB/Swiss-Prot
  PF00787 UniProtKB/Swiss-Prot
  PI3_PI4_kinase UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_rbd UniProtKB/Swiss-Prot
  PI3Ka UniProtKB/Swiss-Prot
PhenoGen Pik3c2g PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot
  PI3K_C2 UniProtKB/Swiss-Prot
  PI3K_RBD UniProtKB/Swiss-Prot
1 to 40 of 59 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-10 Pik3c2g  phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma  Pik3c2g  phosphoinositide-3-kinase, class 2, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pik3c2g  phosphoinositide-3-kinase, class 2, gamma polypeptide  Pik3c2g  phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Pik3c2g  phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Pik3c2g  phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expression increases during liver regeneration with peak expression after the growth period 729517