Slc40a1 (solute carrier family 40 member 1) - Rat Genome Database

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Gene: Slc40a1 (solute carrier family 40 member 1) Rattus norvegicus
Analyze
Symbol: Slc40a1
Name: solute carrier family 40 member 1
RGD ID: 620180
Description: Predicted to enable ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Predicted to be involved in intracellular iron ion homeostasis and iron ion export across plasma membrane. Predicted to act upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; positive regulation of transcription by RNA polymerase II; and spleen trabecula formation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and synaptic vesicle. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1); PARTICIPATES IN iron efflux pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAR1; cell adhesion regulator; ferroportin; ferroportin 1; ferroportin-1; Fpn1; NEWGENE_620180; Slc11a3; Slc39a1; solute carrier family 39 (iron-regulated transporter), member 1; solute carrier family 40 (iron-regulated transporter), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,525,457 - 55,633,463 (-)NCBIGRCr8
mRatBN7.2948,033,526 - 48,053,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,033,526 - 48,051,481 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx956,559,843 - 56,577,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,682,660 - 61,700,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,978,656 - 59,996,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0952,819,451 - 52,830,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,560,116 - 52,579,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4944,977,430 - 44,995,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1944,979,984 - 44,996,778 (-)NCBI
Celera945,700,875 - 45,718,803 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
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Original Reference(s)
Slc40a1RatEhlers-Danlos syndrome classic type 1  ISOSLC40A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome and classic typeClinVarPMID:20648054 more ...
Slc40a1RatEhlers-Danlos Syndrome Type 4  ISOSLC40A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Ehlers-Danlos syndrome and type 4ClinVarPMID:20648054 more ...
Slc40a1Ratgenetic disease  ISOSLC40A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 and PMID:28492532
Slc40a1Rathemochromatosis  ISOSLC40A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary hemochromatosisClinVarPMID:25741868
Slc40a1Rathemochromatosis type 1  ISOSLC40A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hemochromatosis type 1ClinVarPMID:28492532
Slc40a1Rathemochromatosis type 4  ISOSLC40A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11431687 more ...
Slc40a1Ratimmunodeficiency 31B  ISOSLC40A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 31BClinVarPMID:28492532
Slc40a1RatNeurodevelopmental Disorders  ISOSLC40A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
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Original Reference(s)
Slc40a1Rataceruloplasminemia  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20655381
Slc40a1Ratanemia  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16434484
Slc40a1Ratautistic disorder  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15446388
Slc40a1Ratendometriosis  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20864642
Slc40a1Rathemochromatosis  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16457665 and PMID:21411349
Slc40a1Rathemochromatosis type 4  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Slc40a1RatHemolysis  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25247420
Slc40a1RatIron Overload  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17052926
Slc40a1RatLiver Neoplasms  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21785164
Slc40a1RatNeoplastic Cell Transformation  ISOSLC40A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21785164
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Original Reference(s)
Slc40a1Rathemochromatosis type 4  ISSSlc40a1 (Mus musculus)13592920OMIM:606069MouseDO 
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Original Reference(s)
Slc40a1Rathemochromatosis type 4  ISOSLC40A1 (Homo sapiens)7240710 OMIM 

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Original Reference(s)
Slc40a1Rat(+)-catechin multiple interactionsISOSLC40A1 (Homo sapiens)6480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of SLC40A1 mRNACTDPMID:24763279
Slc40a1Rat(+)-dexrazoxane multiple interactionsISOSlc40a1 (Mus musculus)6480464Dexrazoxane inhibits the reaction [Cyclophosphamide results in decreased expression of SLC40A1 protein]CTDPMID:37690746
Slc40a1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSLC40A1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of SLC40A1 mRNACTDPMID:22079256
Slc40a1Rat(1->4)-beta-D-glucan multiple interactionsISOSlc40a1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SLC40A1 mRNACTDPMID:36331819
Slc40a1Rat1,2-dimethylhydrazine decreases expressionISOSlc40a1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of SLC40A1 mRNACTDPMID:22206623
Slc40a1Rat1,3-dichloropropan-2-ol multiple interactionsISOSLC40A1 (Homo sapiens)6480464[Thiazoles binds to indoline] promotes the reaction [1 more ...CTDPMID:35870111
Slc40a1Rat1,3-dichloropropan-2-ol decreases expressionISOSLC40A1 (Homo sapiens)64804641 and 3-dichloro-2-propanol results in decreased expression of SLC40A1 proteinCTDPMID:35870111
Slc40a1Rat1,3-dichloropropan-2-ol decreases expressionISOSlc40a1 (Mus musculus)64804641 and 3-dichloro-2-propanol results in decreased expression of SLC40A1 proteinCTDPMID:35870111
Slc40a1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOSlc40a1 (Mus musculus)64804643 more ...CTDPMID:19679656
Slc40a1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOSlc40a1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:19679656
Slc40a1Rat17alpha-ethynylestradiol affects expressionISOSLC40A1 (Homo sapiens)6480464Ethinyl Estradiol affects the expression of SLC40A1 mRNACTDPMID:20170705
Slc40a1Rat17alpha-ethynylestradiol decreases expressionISOSlc40a1 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of SLC40A1 mRNACTDPMID:27690074
Slc40a1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of SLC40A1 mRNACTDPMID:17108234
Slc40a1Rat17alpha-ethynylestradiol increases expressionISOSlc40a1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of SLC40A1 mRNACTDPMID:17942748
Slc40a1Rat17alpha-ethynylestradiol affects expressionISOSlc40a1 (Mus musculus)6480464Ethinyl Estradiol affects the expression of SLC40A1 mRNACTDPMID:17555576
Slc40a1Rat17beta-estradiol increases expressionISOSlc40a1 (Mus musculus)6480464Estradiol results in increased expression of SLC40A1 mRNACTDPMID:16684588
Slc40a1Rat17beta-estradiol decreases expressionISOSlc40a1 (Mus musculus)6480464Estradiol results in decreased expression of SLC40A1 mRNACTDPMID:39298647
Slc40a1Rat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in increased expression of SLC40A1 mRNACTDPMID:26496021
Slc40a1Rat17beta-estradiol multiple interactionsISOSLC40A1 (Homo sapiens)6480464[Estradiol co-treated with Progesterone] results in decreased expression of SLC40A1 mRNACTDPMID:20660070
Slc40a1Rat2,2',4,4',5,5'-hexachlorobiphenyl increases expressionISOSLC40A1 (Homo sapiens)64804642 more ...CTDPMID:25686467

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Biological Process
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Original Reference(s)
Slc40a1Ratapoptotic process acts_upstream_ofISOSlc40a1 (Mus musculus)1624291MGI:1889622 PMID:15342464RGDPMID:15342464
Slc40a1Ratapoptotic process acts_upstream_ofIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratendothelium development acts_upstream_of_or_withinISOSlc40a1 (Mus musculus)1624291MGI:1889622 PMID:15342464RGDPMID:15342464
Slc40a1Ratendothelium development acts_upstream_of_or_withinIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratestablishment of localization in cell acts_upstream_of_or_withinISOSlc40a1 (Mus musculus)1624291MGI:1933533 PMID:21700773RGDPMID:21700773
Slc40a1Ratestablishment of localization in cell acts_upstream_of_or_withinIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratintracellular iron ion homeostasis involved_inISOSLC40A1 (Homo sapiens)1624291 PMID:12091367RGDPMID:12091367
Slc40a1Ratintracellular iron ion homeostasis involved_inIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratiron ion export across plasma membrane involved_inISSUniProtKB:Q9JHI91600115GO_REF:0000024UniProtGO_REF:0000024
Slc40a1Ratiron ion export across plasma membrane involved_inISOSlc40a1 (Mus musculus)1624291 PMID:15514116 and PMID:30647129RGDPMID:15514116 and PMID:30647129
Slc40a1Ratiron ion export across plasma membrane involved_inIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratiron ion transmembrane transport involved_inIEAInterPro:IPR0097161600115GO_REF:0000002InterProGO_REF:0000002
Slc40a1Ratiron ion transmembrane transport involved_inIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratiron ion transmembrane transport acts_upstream_of_or_withinISOSlc40a1 (Mus musculus)1624291MGI:1933533 PMID:21700773RGDPMID:21700773
Slc40a1Ratiron ion transmembrane transport involved_inIBAMGI:1315204 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc40a1Ratiron ion transmembrane transport acts_upstream_of_or_withinIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratiron ion transmembrane transport involved_inISOSLC40A1 (Homo sapiens)1624291 PMID:12091367RGDPMID:12091367
Slc40a1Ratiron ion transport acts_upstream_of_or_withinISOSlc40a1 (Mus musculus)1624291 PMID:10828623RGDPMID:10828623
Slc40a1Ratiron ion transport  NAS 1304259 RGD 
Slc40a1Ratiron ion transport involved_inIEAUniProtKB-KW:KW-04101600115GO_REF:0000043UniProtGO_REF:0000043
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Cellular Component
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Original Reference(s)
Slc40a1Ratbasolateral plasma membrane located_inISOSlc40a1 (Mus musculus)1624291UniProtKB:P20722 and PMID:19252488RGDPMID:19252488
Slc40a1Ratbasolateral plasma membrane located_inIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratbasolateral plasma membrane located_inIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratbasolateral plasma membrane is_active_inIBAMGI:1315204 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc40a1Ratbasolateral plasma membrane located_inISOSLC40A1 (Homo sapiens)1624291 PMID:20019163 and PMID:29792530RGDPMID:20019163 and PMID:29792530
Slc40a1Ratbasolateral plasma membrane located_inIEAUniProtKB-SubCell:SL-00261600115GO_REF:0000044UniProtGO_REF:0000044
Slc40a1Ratbasolateral plasma membrane is_active_inISOSLC40A1 (Homo sapiens)1624291 PMID:10882071RGDPMID:10882071
Slc40a1Ratcytosol located_inIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratcytosol located_inISOSLC40A1 (Homo sapiens)1624291 RGDGO_REF:0000052
Slc40a1Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Slc40a1Ratmembrane located_inIEAUniRule:UR0009567841600115GO_REF:0000104UniProtGO_REF:0000104
Slc40a1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Slc40a1Ratmembrane located_inIEAInterPro:IPR0097161600115GO_REF:0000002InterProGO_REF:0000002
Slc40a1Ratnucleoplasm located_inISOSLC40A1 (Homo sapiens)1624291 RGDGO_REF:0000052
Slc40a1Ratnucleoplasm located_inIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
Slc40a1Ratplasma membrane located_inIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Slc40a1Ratplasma membrane located_inISOSlc40a1 (Mus musculus)1624291 PMID:16081696 and PMID:21700773RGDPMID:16081696 and PMID:21700773
Slc40a1Ratplasma membrane located_inISOSLC40A1 (Homo sapiens)1624291 PMID:20019163 and PMID:30247984RGDGO_REF:0000052 more ...
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Molecular Function
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Original Reference(s)
Slc40a1Ratferrous iron transmembrane transporter activity enablesISOSLC40A1 (Homo sapiens)1624291 PMID:15692071RGDPMID:15692071
Slc40a1Ratferrous iron transmembrane transporter activity enablesISOSlc40a1 (Mus musculus)1624291 PMID:15514116RGDPMID:15514116
Slc40a1Ratferrous iron transmembrane transporter activity enablesIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratferrous iron transmembrane transporter activity enablesIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratidentical protein binding enablesISOSlc40a1 (Mus musculus)1624291UniProtKB:Q9JHI9 and PMID:19234114RGDPMID:19234114
Slc40a1Ratidentical protein binding enablesIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratiron ion transmembrane transporter activity enablesIEAUniRule:UR0009567841600115GO_REF:0000104UniProtGO_REF:0000104
Slc40a1Ratiron ion transmembrane transporter activity  NAS 1304259 RGD 
Slc40a1Ratiron ion transmembrane transporter activity enablesIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratiron ion transmembrane transporter activity enablesIBAMGI:1315204 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc40a1Ratiron ion transmembrane transporter activity enablesISOSlc40a1 (Mus musculus)1624291 PMID:10828623 and PMID:15514116RGDPMID:10828623 and PMID:15514116
Slc40a1Ratiron ion transmembrane transporter activity enablesIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratiron ion transmembrane transporter activity enablesIEAInterPro:IPR0097161600115GO_REF:0000002InterProGO_REF:0000002
Slc40a1Ratiron ion transmembrane transporter activity enablesISOSLC40A1 (Homo sapiens)1624291 PMID:12091367RGDPMID:12091367
Slc40a1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Slc40a1Ratpeptide hormone binding enablesISOSLC40A1 (Homo sapiens)1624291UniProtKB:P81172-PRO_0000013379 more ...RGDPMID:22682227 and PMID:29237594
Slc40a1Ratpeptide hormone binding enablesISOSlc40a1 (Mus musculus)1624291UniProtKB:P81172-PRO_0000013379 and PMID:15514116RGDPMID:15514116
Slc40a1Ratpeptide hormone binding enablesIBAMGI:1315204 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc40a1Ratpeptide hormone binding enablesIEAUniProtKB:Q9NP59 and ensembl:ENSP000002610241600115GO_REF:0000107EnsemblGO_REF:0000107
Slc40a1Ratpeptide hormone binding enablesIEAUniProtKB:Q9JHI9 and ensembl:ENSMUSP000000271371600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Original Reference(s)
Slc40a1Ratiron efflux pathway  ISOSLC40A1 (Homo sapiens)11534369 RGD 

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Reference Title
Reference Citation
1. Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis. di Patti MC, etal., Neurosci Lett 2004 Jun 10;363(2):182-6.
2. Ironing out Ferroportin. Drakesmith H, etal., Cell Metab. 2015 Nov 3;22(5):777-87. doi: 10.1016/j.cmet.2015.09.006. Epub 2015 Oct 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Itoh A, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):175-86.
5. Distribution of ferroportin1 protein in different regions of developing rat brain. Jiang DH, etal., Dev Neurosci 2002;24(2-3):94-8.
6. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Leong WI, etal., Am J Physiol Gastrointest Liver Physiol 2003 Dec;285(6):G1153-61. Epub 2003 Sep 04.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis. Wallace DF, etal., Blood 2002 Jul 15;100(2):692-4.
14. Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Yeh KY, etal., Am J Physiol Gastrointest Liver Physiol 2004 Mar;286(3):G385-94. Epub 2003 Oct 30.
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PMID:8889548   PMID:10477520   PMID:10828623   PMID:12091367   PMID:12431995   PMID:14972659   PMID:15084469   PMID:15114483   PMID:15342464   PMID:15514116   PMID:15888661   PMID:15944915  
PMID:16081696   PMID:17383861   PMID:17561842   PMID:18189270   PMID:18839536   PMID:18974313   PMID:19234114   PMID:19252488   PMID:19596281   PMID:19766498   PMID:19913091   PMID:20007457  
PMID:20019163   PMID:20530874   PMID:20564203   PMID:21473866   PMID:21570398   PMID:21700773   PMID:21785164   PMID:22469696   PMID:22659129   PMID:22682227   PMID:23395172   PMID:23506423  
PMID:24174620   PMID:25115800   PMID:25318588   PMID:25745840   PMID:26617777   PMID:26788496   PMID:28273797   PMID:29757912   PMID:30027341   PMID:34748769  



Slc40a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,525,457 - 55,633,463 (-)NCBIGRCr8
mRatBN7.2948,033,526 - 48,053,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,033,526 - 48,051,481 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx956,559,843 - 56,577,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,682,660 - 61,700,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,978,656 - 59,996,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0952,819,451 - 52,830,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,560,116 - 52,579,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4944,977,430 - 44,995,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1944,979,984 - 44,996,778 (-)NCBI
Celera945,700,875 - 45,718,803 (-)NCBICelera
Cytogenetic Map9q22NCBI
SLC40A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382189,560,590 - 189,580,786 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2189,560,590 - 189,583,758 (-)EnsemblGRCh38hg38GRCh38
GRCh372190,425,316 - 190,445,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,133,561 - 190,153,858 (-)NCBINCBI36Build 36hg18NCBI36
Build 342190,250,823 - 190,271,119NCBI
Celera2184,020,234 - 184,040,455 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,284,805 - 182,305,032 (-)NCBIHuRef
CHM1_12190,431,102 - 190,451,326 (-)NCBICHM1_1
T2T-CHM13v2.02190,049,828 - 190,070,025 (-)NCBIT2T-CHM13v2.0
Slc40a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39145,947,230 - 45,965,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl145,947,228 - 45,965,683 (-)EnsemblGRCm39 Ensembl
GRCm38145,908,070 - 45,926,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl145,908,068 - 45,926,523 (-)EnsemblGRCm38mm10GRCm38
MGSCv37145,964,915 - 45,982,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36145,852,630 - 45,870,079 (-)NCBIMGSCv36mm8
Celera146,240,344 - 46,257,933 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.96NCBI
Slc40a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554039,253,734 - 9,271,916 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554039,253,734 - 9,271,732 (+)NCBIChiLan1.0ChiLan1.0
SLC40A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,254,018 - 92,274,565 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,269,001 - 92,289,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B76,867,908 - 76,888,403 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B194,787,575 - 194,808,129 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B194,787,575 - 194,810,993 (-)Ensemblpanpan1.1panPan2
SLC40A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137308,054 - 329,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37303,104 - 368,865 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha371,278,631 - 1,299,609 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.037196,731 - 217,705 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37183,743 - 312,839 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137209,278 - 230,249 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037177,455 - 198,429 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037205,666 - 226,640 (-)NCBIUU_Cfam_GSD_1.0
Slc40a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,421,846 - 148,441,474 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365068,396,912 - 8,416,374 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365068,396,593 - 8,415,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC40A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,141,988 - 94,167,408 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11594,140,635 - 94,161,793 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,177,377 - 105,198,528 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC40A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,076,286 - 75,097,742 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,075,971 - 75,096,271 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040124,382,259 - 124,402,681 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc40a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899685,097 - 702,440 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624899685,166 - 701,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Slc40a1
133 total Variants

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:237
Interacting mature miRNAs:285
Transcripts:ENSRNOT00000005228, ENSRNOT00000073557
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 30 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat

1 to 10 of 30 rows
D9Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,035,934 - 48,036,057 (+)MAPPERmRatBN7.2
Rnor_6.0952,896,774 - 52,896,896NCBIRnor6.0
Rnor_6.0952,821,860 - 52,821,982NCBIRnor6.0
Rnor_5.0952,562,590 - 52,562,712UniSTSRnor5.0
Rnor_5.0952,487,676 - 52,487,798UniSTSRnor5.0
RGSC_v3.4944,979,838 - 44,979,961RGDRGSC3.4
RGSC_v3.4944,979,839 - 44,979,961UniSTSRGSC3.4
RGSC_v3.1944,981,242 - 44,981,612RGD
Celera945,703,284 - 45,703,406UniSTS
SHRSP x BN Map941.0698UniSTS
SHRSP x BN Map941.0698RGD
FHH x ACI Map932.43RGD
Cytogenetic Map9q22UniSTS
RH129386  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,033,867 - 48,034,064 (+)MAPPERmRatBN7.2
Rnor_6.0952,894,707 - 52,894,903NCBIRnor6.0
Rnor_6.0952,819,793 - 52,819,989NCBIRnor6.0
Rnor_5.0952,485,609 - 52,485,805UniSTSRnor5.0
Rnor_5.0952,560,523 - 52,560,719UniSTSRnor5.0
RGSC_v3.4944,977,772 - 44,977,968UniSTSRGSC3.4
Celera945,701,217 - 45,701,413UniSTS
Cytogenetic Map9q22UniSTS
RH136898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,034,706 - 48,034,886 (+)MAPPERmRatBN7.2
Rnor_6.0952,820,632 - 52,820,811NCBIRnor6.0
Rnor_6.0952,895,546 - 52,895,725NCBIRnor6.0
Rnor_5.0952,486,448 - 52,486,627UniSTSRnor5.0
Rnor_5.0952,561,362 - 52,561,541UniSTSRnor5.0
RGSC_v3.4944,978,611 - 44,978,790UniSTSRGSC3.4
Celera945,702,056 - 45,702,235UniSTS
Cytogenetic Map9q22UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 88 87 56 25 56 6 214 97 93 44 60 31



Ensembl Acc Id: ENSRNOT00000005228   ⟹   ENSRNOP00000005228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,033,527 - 48,051,481 (-)Ensembl
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095235   ⟹   ENSRNOP00000086572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,033,526 - 48,049,019 (-)Ensembl
RefSeq Acc Id: NM_133315   ⟹   NP_579849
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,532 - 55,543,460 (-)NCBI
mRatBN7.2948,033,526 - 48,051,455 (-)NCBI
Rnor_6.0952,819,451 - 52,830,461 (-)NCBI
Rnor_5.0952,560,116 - 52,579,079 (-)NCBI
RGSC_v3.4944,977,430 - 44,995,358 (-)RGD
Celera945,700,875 - 45,718,803 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082988   ⟹   XP_038938916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,457 - 55,633,463 (-)NCBI
mRatBN7.2948,033,541 - 48,053,876 (-)NCBI
RefSeq Acc Id: XM_063266613   ⟹   XP_063122683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,457 - 55,633,463 (-)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_579849 (Get FASTA)   NCBI Sequence Viewer  
  XP_038938916 (Get FASTA)   NCBI Sequence Viewer  
  XP_063122683 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD00260 (Get FASTA)   NCBI Sequence Viewer  
  AAK77858 (Get FASTA)   NCBI Sequence Viewer  
  EDL99122 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005228
  ENSRNOP00055005787
  ENSRNOP00060023164
  ENSRNOP00065042776
GenBank Protein Q923U9 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_579849   ⟸   NM_133315
- UniProtKB: Q9Z1C9 (UniProtKB/Swiss-Prot),   Q923U9 (UniProtKB/Swiss-Prot),   G3V6H7 (UniProtKB/TrEMBL),   A6INT8 (UniProtKB/TrEMBL),   A0A9M1WP97 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005228   ⟸   ENSRNOT00000005228
RefSeq Acc Id: XP_038938916   ⟸   XM_039082988
- Peptide Label: isoform X1
- UniProtKB: Q923U9 (UniProtKB/Swiss-Prot),   G3V6H7 (UniProtKB/Swiss-Prot),   Q9Z1C9 (UniProtKB/Swiss-Prot),   A6INT8 (UniProtKB/TrEMBL),   A0A9M1WP97 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000086572   ⟸   ENSRNOT00000095235
RefSeq Acc Id: XP_063122683   ⟸   XM_063266613
- Peptide Label: isoform X1
- UniProtKB: Q9Z1C9 (UniProtKB/Swiss-Prot),   Q923U9 (UniProtKB/Swiss-Prot),   G3V6H7 (UniProtKB/Swiss-Prot),   A6INT8 (UniProtKB/TrEMBL),   A0A9M1WP97 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-Q923U9-F1-model_v2 AlphaFold Q923U9 1-570 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27634 BioCyc
Ensembl Genes ENSRNOG00000003872 Ensembl, ENTREZGENE
  ENSRNOG00055004811 UniProtKB/Swiss-Prot
  ENSRNOG00060016832 UniProtKB/Swiss-Prot
  ENSRNOG00065030099 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005228 ENTREZGENE
  ENSRNOT00055007668 UniProtKB/Swiss-Prot
  ENSRNOT00060028791 UniProtKB/Swiss-Prot
  ENSRNOT00065051968 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
InterPro Ferroportin-1 UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
KEGG Report rno:170840 UniProtKB/Swiss-Prot
NCBI Gene 170840 ENTREZGENE
PANTHER PTHR11660 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 40 MEMBER 1 UniProtKB/Swiss-Prot
Pfam FPN1 UniProtKB/Swiss-Prot
PhenoGen Slc40a1 PhenoGen
RatGTEx ENSRNOG00000003872 RatGTEx
  ENSRNOG00055004811 RatGTEx
  ENSRNOG00060016832 RatGTEx
  ENSRNOG00065030099 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0A8I6A631_RAT UniProtKB/TrEMBL
  A0A9M1WP97 ENTREZGENE, UniProtKB/TrEMBL
  A6INT8 ENTREZGENE, UniProtKB/TrEMBL
  G3V6H7 ENTREZGENE
  Q923U9 ENTREZGENE
  Q9Z1C9 ENTREZGENE
  S40A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary G3V6H7 UniProtKB/Swiss-Prot
  Q9Z1C9 UniProtKB/Swiss-Prot
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc40a1  solute carrier family 40 member 1  NEWGENE_620180  solute carrier family 40 member 1  Data merged from RGD:11441106 737654 PROVISIONAL
2016-08-02 NEWGENE_620180  solute carrier family 40 member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-03-09 Slc40a1  solute carrier family 40 member 1  Slc40a1  solute carrier family 40 (iron-regulated transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc40a1  solute carrier family 40 (iron-regulated transporter), member 1  Slc40a1  solute carrier family 39 (iron-regulated transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc40a1  solute carrier family 39 (iron-regulated transporter), member 1  Slc39a1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Slc39a1  solute carrier family 39 (iron-regulated transporter), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_expression expressed in many specific regions of the brain 634086
gene_regulation expression downregulated by hepcidin in an LPS-induced manner 1304454