Slc40a1 (solute carrier family 40 member 1) - Rat Genome Database

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Gene: Slc40a1 (solute carrier family 40 member 1) Rattus norvegicus
Analyze
Symbol: Slc40a1
Name: solute carrier family 40 member 1
RGD ID: 620180
Description: Predicted to enable ferrous iron transmembrane transporter activity; identical protein binding activity; and peptide hormone binding activity. Predicted to be involved in intracellular iron ion homeostasis and iron ion export across plasma membrane. Predicted to act upstream of or within several processes, including multicellular organismal-level iron ion homeostasis; positive regulation of transcription by RNA polymerase II; and spleen trabecula formation. Predicted to be located in several cellular components, including cytosol; nucleoplasm; and synaptic vesicle. Predicted to be active in basolateral plasma membrane. Human ortholog(s) of this gene implicated in hemochromatosis type 4. Orthologous to human SLC40A1 (solute carrier family 40 member 1); PARTICIPATES IN iron efflux pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CAR1; cell adhesion regulator; ferroportin 1; ferroportin-1; Fpn1; NEWGENE_620180; Slc11a3; Slc39a1; solute carrier family 39 (iron-regulated transporter), member 1; solute carrier family 40 (iron-regulated transporter), member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,525,457 - 55,633,463 (-)NCBIGRCr8
mRatBN7.2948,033,526 - 48,053,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,033,526 - 48,051,481 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx956,559,843 - 56,577,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,682,660 - 61,700,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,978,656 - 59,996,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0952,819,451 - 52,830,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,560,116 - 52,579,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4944,977,430 - 44,995,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1944,979,984 - 44,996,778 (-)NCBI
Celera945,700,875 - 45,718,803 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-dexrazoxane  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-dihydroxybenzoate  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-tert-Octylphenol  (EXP)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
actinomycin D  (ISO)
aflatoxin B1  (EXP,ISO)
alcohol  (ISO)
all-trans-retinoic acid  (EXP,ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apocynin  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atrazine  (EXP)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
busulfan  (ISO)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (EXP,ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethyl maleate  (ISO)
diethylstilbestrol  (EXP)
dimethyl fumarate  (ISO)
diquat  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
erastin  (EXP,ISO)
ethanol  (ISO)
ferric ammonium citrate  (EXP,ISO)
ferrostatin-1  (ISO)
flutamide  (EXP)
folic acid  (ISO)
gadolinium trichloride  (EXP)
Gastrodin  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
hexane  (ISO)
hypochlorous acid  (ISO)
indoline  (ISO)
indometacin  (ISO)
inulin  (ISO)
iron atom  (EXP,ISO)
iron dextran  (ISO)
iron dichloride  (ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (ISO)
isoprenaline  (ISO)
L-glutamic acid  (ISO)
lamivudine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (EXP)
mercury dibromide  (ISO)
mercury dichloride  (EXP)
methamphetamine  (EXP)
methapyrilene  (ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
mithramycin  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naphthalene  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
nitric oxide  (EXP)
nitrofen  (EXP)
omeprazole  (ISO)
oxidopamine  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
pentachlorophenol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
permethrin  (EXP)
phenacetin  (EXP)
phenobarbital  (ISO)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
phorone  (EXP)
pirinixic acid  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
quercetin  (EXP,ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thiazoles  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
toosendanin  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interleukin-1beta up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis. di Patti MC, etal., Neurosci Lett 2004 Jun 10;363(2):182-6.
2. Ironing out Ferroportin. Drakesmith H, etal., Cell Metab. 2015 Nov 3;22(5):777-87. doi: 10.1016/j.cmet.2015.09.006. Epub 2015 Oct 1.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system. Itoh A, etal., Brain Res Mol Brain Res 1998 Nov 20;62(2):175-86.
5. Distribution of ferroportin1 protein in different regions of developing rat brain. Jiang DH, etal., Dev Neurosci 2002;24(2-3):94-8.
6. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Leong WI, etal., Am J Physiol Gastrointest Liver Physiol 2003 Dec;285(6):G1153-61. Epub 2003 Sep 04.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Novel mutation in ferroportin1 is associated with autosomal dominant hemochromatosis. Wallace DF, etal., Blood 2002 Jul 15;100(2):692-4.
14. Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Yeh KY, etal., Am J Physiol Gastrointest Liver Physiol 2004 Mar;286(3):G385-94. Epub 2003 Oct 30.
Additional References at PubMed
PMID:8889548   PMID:10477520   PMID:10828623   PMID:12091367   PMID:12431995   PMID:14972659   PMID:15084469   PMID:15114483   PMID:15342464   PMID:15514116   PMID:15888661   PMID:15944915  
PMID:16081696   PMID:17383861   PMID:17561842   PMID:18189270   PMID:18839536   PMID:18974313   PMID:19234114   PMID:19252488   PMID:19596281   PMID:19766498   PMID:19913091   PMID:20007457  
PMID:20019163   PMID:20530874   PMID:20564203   PMID:21473866   PMID:21570398   PMID:21700773   PMID:21785164   PMID:22469696   PMID:22659129   PMID:22682227   PMID:23395172   PMID:23506423  
PMID:24174620   PMID:25115800   PMID:25318588   PMID:25745840   PMID:26617777   PMID:26788496   PMID:28273797   PMID:29757912   PMID:30027341   PMID:34748769  


Genomics

Comparative Map Data
Slc40a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8955,525,457 - 55,633,463 (-)NCBIGRCr8
mRatBN7.2948,033,526 - 48,053,876 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl948,033,526 - 48,051,481 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx956,559,843 - 56,577,824 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0961,682,660 - 61,700,640 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0959,978,656 - 59,996,636 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0952,819,451 - 52,830,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0952,560,116 - 52,579,079 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4944,977,430 - 44,995,358 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1944,979,984 - 44,996,778 (-)NCBI
Celera945,700,875 - 45,718,803 (-)NCBICelera
Cytogenetic Map9q22NCBI
SLC40A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382189,560,590 - 189,580,786 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2189,560,590 - 189,583,758 (-)EnsemblGRCh38hg38GRCh38
GRCh372190,425,316 - 190,445,512 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362190,133,561 - 190,153,858 (-)NCBINCBI36Build 36hg18NCBI36
Build 342190,250,823 - 190,271,119NCBI
Celera2184,020,234 - 184,040,455 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2182,284,805 - 182,305,032 (-)NCBIHuRef
CHM1_12190,431,102 - 190,451,326 (-)NCBICHM1_1
T2T-CHM13v2.02190,049,828 - 190,070,025 (-)NCBIT2T-CHM13v2.0
Slc40a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39145,947,230 - 45,965,690 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl145,947,228 - 45,965,683 (-)EnsemblGRCm39 Ensembl
GRCm38145,908,070 - 45,926,532 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl145,908,068 - 45,926,523 (-)EnsemblGRCm38mm10GRCm38
MGSCv37145,964,915 - 45,982,439 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36145,852,630 - 45,870,079 (-)NCBIMGSCv36mm8
Celera146,240,344 - 46,257,933 (-)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.96NCBI
Slc40a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554039,253,734 - 9,271,916 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554039,253,734 - 9,271,732 (+)NCBIChiLan1.0ChiLan1.0
SLC40A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21392,254,018 - 92,274,565 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B92,269,001 - 92,289,544 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B76,867,908 - 76,888,403 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B194,787,575 - 194,808,129 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B194,787,575 - 194,810,993 (-)Ensemblpanpan1.1panPan2
SLC40A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137308,054 - 329,037 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37303,104 - 368,865 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha371,278,631 - 1,299,609 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.037196,731 - 217,705 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37183,743 - 312,839 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137209,278 - 230,249 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037177,455 - 198,429 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037205,666 - 226,640 (-)NCBIUU_Cfam_GSD_1.0
Slc40a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303148,421,846 - 148,441,474 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365068,396,912 - 8,416,374 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365068,396,593 - 8,415,069 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC40A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1594,141,988 - 94,167,408 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11594,140,635 - 94,161,793 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215105,177,377 - 105,198,528 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC40A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11075,076,286 - 75,097,742 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1075,075,971 - 75,096,271 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040124,382,259 - 124,402,681 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc40a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624899685,097 - 702,440 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624899685,166 - 701,725 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc40a1
133 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:464
Count of miRNA genes:237
Interacting mature miRNAs:285
Transcripts:ENSRNOT00000005228, ENSRNOT00000073557
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10054125Srcrt7Stress Responsive Cort QTL 73.330.0011blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)9187073594Rat
1331757Cdexp1CD45RC expression in CD8 T cells QTL 14.3CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)9102453767509080Rat
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
11353947Bp392Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)9728325252283252Rat
9589133Insul26Insulin level QTL 2617.960.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)9895256053952560Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
1598823Memor16Memory QTL 161.9exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)92213332249968732Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
7207814Bmd91Bone mineral density QTL 913.5femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)92375414483851531Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat
1641894Alcrsp12Alcohol response QTL 12response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)92746863972468639Rat
7411656Foco26Food consumption QTL 269.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)93253550577535505Rat
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1598834Memor11Memory QTL 112.5exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)93696235977814038Rat
8662828Vetf6Vascular elastic tissue fragility QTL 63.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)93696235992058970Rat
2290450Scl57Serum cholesterol level QTL 574.15blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)93696235995410867Rat
6903941Pur31Proteinuria QTL 310.036urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)94019418885194188Rat
11353949Bp393Blood pressure QTL 393arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94019418885194188Rat
61352Bp34Blood pressure QTL 345arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94249534379271511Rat
10058949Gmadr5Adrenal mass QTL 520.014adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)94279151387976209Rat
11353951Bp394Blood pressure QTL 394arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94464992189649921Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
6903937Bp356Blood pressure QTL 3560.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)94790220852283252Rat

Markers in Region
D9Rat60  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,035,934 - 48,036,057 (+)MAPPERmRatBN7.2
Rnor_6.0952,896,774 - 52,896,896NCBIRnor6.0
Rnor_6.0952,821,860 - 52,821,982NCBIRnor6.0
Rnor_5.0952,562,590 - 52,562,712UniSTSRnor5.0
Rnor_5.0952,487,676 - 52,487,798UniSTSRnor5.0
RGSC_v3.4944,979,838 - 44,979,961RGDRGSC3.4
RGSC_v3.4944,979,839 - 44,979,961UniSTSRGSC3.4
RGSC_v3.1944,981,242 - 44,981,612RGD
Celera945,703,284 - 45,703,406UniSTS
SHRSP x BN Map941.0698UniSTS
SHRSP x BN Map941.0698RGD
FHH x ACI Map932.43RGD
Cytogenetic Map9q22UniSTS
RH129386  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,033,867 - 48,034,064 (+)MAPPERmRatBN7.2
Rnor_6.0952,894,707 - 52,894,903NCBIRnor6.0
Rnor_6.0952,819,793 - 52,819,989NCBIRnor6.0
Rnor_5.0952,485,609 - 52,485,805UniSTSRnor5.0
Rnor_5.0952,560,523 - 52,560,719UniSTSRnor5.0
RGSC_v3.4944,977,772 - 44,977,968UniSTSRGSC3.4
Celera945,701,217 - 45,701,413UniSTS
Cytogenetic Map9q22UniSTS
RH136898  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2948,034,706 - 48,034,886 (+)MAPPERmRatBN7.2
Rnor_6.0952,820,632 - 52,820,811NCBIRnor6.0
Rnor_6.0952,895,546 - 52,895,725NCBIRnor6.0
Rnor_5.0952,486,448 - 52,486,627UniSTSRnor5.0
Rnor_5.0952,561,362 - 52,561,541UniSTSRnor5.0
RGSC_v3.4944,978,611 - 44,978,790UniSTSRGSC3.4
Celera945,702,056 - 45,702,235UniSTS
Cytogenetic Map9q22UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 2 37 37 11 37 34 21 1
Low 2 41 20 4 8 4 8 11 74 1 20 10 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005228   ⟹   ENSRNOP00000005228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,033,527 - 48,051,481 (-)Ensembl
Rnor_6.0 Ensembl952,894,365 - 52,912,293 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095235   ⟹   ENSRNOP00000086572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl948,033,526 - 48,049,019 (-)Ensembl
RefSeq Acc Id: NM_133315   ⟹   NP_579849
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,532 - 55,543,460 (-)NCBI
mRatBN7.2948,033,526 - 48,051,455 (-)NCBI
Rnor_6.0952,819,451 - 52,830,461 (-)NCBI
Rnor_5.0952,560,116 - 52,579,079 (-)NCBI
RGSC_v3.4944,977,430 - 44,995,358 (-)RGD
Celera945,700,875 - 45,718,803 (-)RGD
Sequence:
RefSeq Acc Id: XM_039082988   ⟹   XP_038938916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,457 - 55,633,463 (-)NCBI
mRatBN7.2948,033,541 - 48,053,876 (-)NCBI
RefSeq Acc Id: XM_063266613   ⟹   XP_063122683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8955,525,457 - 55,633,463 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_579849   ⟸   NM_133315
- UniProtKB: Q9Z1C9 (UniProtKB/Swiss-Prot),   Q923U9 (UniProtKB/Swiss-Prot),   G3V6H7 (UniProtKB/TrEMBL),   A6INT8 (UniProtKB/TrEMBL),   A0A9M1WP97 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000005228   ⟸   ENSRNOT00000005228
RefSeq Acc Id: XP_038938916   ⟸   XM_039082988
- Peptide Label: isoform X1
- UniProtKB: Q923U9 (UniProtKB/Swiss-Prot),   G3V6H7 (UniProtKB/Swiss-Prot),   Q9Z1C9 (UniProtKB/Swiss-Prot),   A6INT8 (UniProtKB/TrEMBL),   A0A9M1WP97 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000086572   ⟸   ENSRNOT00000095235
RefSeq Acc Id: XP_063122683   ⟸   XM_063266613
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q923U9-F1-model_v2 AlphaFold Q923U9 1-570 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620180 AgrOrtholog
BioCyc Gene G2FUF-27634 BioCyc
Ensembl Genes ENSRNOG00000003872 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000005228 ENTREZGENE
  ENSRNOT00000005228.4 UniProtKB/TrEMBL
  ENSRNOT00000095235.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Ferroportin-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:170840 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 170840 ENTREZGENE
PANTHER PTHR11660 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 40 MEMBER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FPN1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc40a1 PhenoGen
RatGTEx ENSRNOG00000003872 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A631_RAT UniProtKB/TrEMBL
  A0A9M1WP97 ENTREZGENE, UniProtKB/TrEMBL
  A6INT8 ENTREZGENE, UniProtKB/TrEMBL
  G3V6H7 ENTREZGENE
  Q923U9 ENTREZGENE
  Q9Z1C9 ENTREZGENE
  S40A1_RAT UniProtKB/Swiss-Prot
UniProt Secondary G3V6H7 UniProtKB/Swiss-Prot
  Q9Z1C9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Slc40a1  solute carrier family 40 member 1  NEWGENE_620180  solute carrier family 40 member 1  Data merged from RGD:11441106 737654 PROVISIONAL
2016-08-02 NEWGENE_620180  solute carrier family 40 member 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2016-03-09 Slc40a1  solute carrier family 40 member 1  Slc40a1  solute carrier family 40 (iron-regulated transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Slc40a1  solute carrier family 40 (iron-regulated transporter), member 1  Slc40a1  solute carrier family 39 (iron-regulated transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc40a1  solute carrier family 39 (iron-regulated transporter), member 1  Slc39a1    Symbol and Name updated 1299863 APPROVED
2002-08-07 Slc39a1  solute carrier family 39 (iron-regulated transporter), member 1      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in many specific regions of the brain 634086
gene_regulation expression downregulated by hepcidin in an LPS-induced manner 1304454