Prdx1 (peroxiredoxin 1) - Rat Genome Database

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Gene: Prdx1 (peroxiredoxin 1) Rattus norvegicus
Analyze
Symbol: Prdx1
Name: peroxiredoxin 1
RGD ID: 620039
Description: Enables heme binding activity; identical protein binding activity; and peroxiredoxin activity. Involved in response to oxidative stress. Located in euchromatin; mitochondrial matrix; and peroxisomal matrix. Human ortholog(s) of this gene implicated in methylmalonic aciduria and homocystinuria type cblC. Orthologous to human PRDX1 (peroxiredoxin 1); INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Hbp23; heme-binding 23 kDa protein; MGC108617; peroxiredoxin-1; thioredoxin peroxidase 2; thioredoxin-dependent peroxide reductase 2; thioredoxin-dependent peroxiredoxin 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,383,906 - 135,399,504 (+)NCBIGRCr8
mRatBN7.25130,147,258 - 130,162,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,147,204 - 130,162,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,772,005 - 132,788,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,526,605 - 134,543,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,549,011 - 134,565,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,536,413 - 135,551,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,536,413 - 135,551,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,332,556 - 139,348,210 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,975,780 - 136,991,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,981,005 - 136,996,856 (+)NCBI
Celera5128,674,439 - 128,690,018 (+)NCBICelera
Cytogenetic Map5q35NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Prdx1RatCOVID-19  ISORGD:7337449068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226|REF_RGD_ID:28912744
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Prdx1RatCharcot-Marie-Tooth disease dominant intermediate C  ISORGD:7337448554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532
Prdx1Ratdevelopmental and epileptic encephalopathy  ISORGD:7337448554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathyClinVarPMID:28492532
Prdx1Ratearly infantile epileptic encephalopathy  ISORGD:7337448554872ClinVar Annotator: match by term: Early infantile epileptic encephalopathyClinVarPMID:28492532
Prdx1Ratgenetic disease  ISORGD:7337448554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28492532
Prdx1Ratmethylmalonic aciduria and homocystinuria type cblC  ISORGD:7337448554872ClinVar Annotator: match by term: Methylmalonic aciduria and homocystinuria, Vitamin B12-responsive | ClinVar Annotator: match more ...ClinVarPMID:16311595|PMID:17576681|PMID:20631720|PMID:23954310|PMID:25388550|PMID:25741868|PMID:25772322|PMID:27383490|PMID:28327205|PMID:28492532|PMID:29302025|PMID:32099815|PMID:34215320|PMID:35190856|PMID:9536098
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Prdx1Ratasbestosis  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:22537621
Prdx1RatEsophageal Neoplasms  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:15986332
Prdx1Ratesophagus squamous cell carcinoma  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:21517111
Prdx1RatExperimental Liver Neoplasms  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:27517622
Prdx1Rathepatocellular carcinoma  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:27517622
Prdx1RatKeloid  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:20128793
Prdx1RatLung Neoplasms  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:22537621
Prdx1Ratlung non-small cell carcinoma  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:17094902
Prdx1Ratmethylmalonic aciduria and homocystinuria type cblC  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTD 
Prdx1Ratpre-malignant neoplasm  ISORGD:73374411554173CTD Direct Evidence: marker/mechanismCTDPMID:15986332
Prdx1Ratschistosomiasis  ISORGD:73374411554173CTD Direct Evidence: therapeuticCTDPMID:19041905
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Prdx1Ratmethylmalonic aciduria and homocystinuria type cblC  ISORGD:7337447240710 OMIM 

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Prdx1Rat(+)-catechin multiple interactionsISORGD:7337446480464[Catechin co-treated with Grape Seed Proanthocyanidins] results in increased expression of PRDX1 mRNACTDPMID:24763279
Prdx1Rat(1->4)-beta-D-glucan multiple interactionsISORGD:7337456480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRDX1 mRNACTDPMID:36331819
Prdx1Rat(S)-naringenin decreases expressionISORGD:7337446480464naringenin results in decreased expression of PRDX1 mRNA; naringenin results in decreased expression of PRDX1 more ...CTDPMID:27838343
Prdx1Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of PRDX1 proteinCTDPMID:17337753
Prdx1Rat1,2-dichloroethane decreases expressionISORGD:7337456480464ethylene dichloride results in decreased expression of PRDX1 mRNACTDPMID:28960355
Prdx1Rat1,2-dimethylhydrazine multiple interactionsISORGD:7337456480464[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PRDX1 mRNACTDPMID:22206623
Prdx1Rat1-chloro-2,4-dinitrobenzene affects oxidationISORGD:7337446480464Dinitrochlorobenzene affects the oxidation of PRDX1 proteinCTDPMID:18789312
Prdx1Rat1-chloro-2,4-dinitrobenzene affects bindingISORGD:7337446480464Dinitrochlorobenzene binds to PRDX1 proteinCTDPMID:32991956
Prdx1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of PRDX1 mRNACTDPMID:15576828|PMID:16174780|PMID:17557909
Prdx1Rat17beta-estradiol affects expressionISORGD:7337446480464Estradiol affects the expression of PRDX1 mRNACTDPMID:22574217
Prdx1Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one affects splicingISORGD:7337446480464Metribolone affects the splicing of PRDX1 mRNACTDPMID:17010196
Prdx1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionISORGD:73374464804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRDX1 mRNACTDPMID:26808241
Prdx1Rat2,3,7,8-tetrabromodibenzodioxine increases expressionISORGD:73374564804642,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of PRDX1 proteinCTDPMID:27604104
Prdx1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:7337456480464Tetrachlorodibenzodioxin affects the expression of PRDX1 mRNACTDPMID:21570461
Prdx1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PRDX1 mRNACTDPMID:34747641
Prdx1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORGD:7337456480464Tetrachlorodibenzodioxin results in decreased expression of PRDX1 mRNACTDPMID:28213091
Prdx1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORGD:7337456480464[NFE2L2 gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression more ...CTDPMID:21846477
Prdx1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISORGD:7337456480464Tetrachlorodibenzodioxin results in increased expression of PRDX1 mRNACTDPMID:15034205|PMID:15591033
Prdx1Rat2,4-diaminotoluene increases expressionISORGD:73374564804642,4-diaminotoluene results in increased expression of PRDX1 mRNACTDPMID:22016648
Prdx1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISORGD:73374564804642,2',4,4',5-brominated diphenyl ether affects the expression of PRDX1 mRNACTDPMID:38648751

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Biological Process
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Prdx1Ratcanonical NF-kappaB signal transduction acts_upstream_of_negative_effectISORGD:7337451624291 PMID:15858817RGDPMID:15858817
Prdx1Ratcell redox homeostasis involved_inIBAFB:FBgn0038519|FB:FBgn0040309|MGI:1859815|PANTHER:PTN000073874|PomBase:SPCC576.03c|SGD:S000002861|SGD:S000004490|TAIR:locus:2080707|TAIR:locus:2164265|UniProtKB:P9WQB71600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1Raterythrocyte homeostasis acts_upstream_of_or_withinISORGD:7337451624291MGI:2670538 PMID:12891360RGDPMID:12891360
Prdx1Ratfibroblast proliferation acts_upstream_of_or_withinISORGD:7337451624291MGI:2670538 PMID:12891360RGDPMID:12891360
Prdx1Rathydrogen peroxide catabolic process involved_inISORGD:7337441624291 PMID:18606987RGDPMID:18606987
Prdx1Rathydrogen peroxide catabolic process involved_inIBACGD:CAL0000174369|FB:FBgn0038519|FB:FBgn0040308|FB:FBgn0040309|MGI:109486|PANTHER:PTN000073874|PomBase:SPCC576.03c|UniProtKB:P0AE08|UniProtKB:P0CU34|UniProtKB:P30048|UniProtKB:Q06830|UniProtKB:Q6ER94|WB:WBGene000064341600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1Rathydrogen peroxide catabolic process acts_upstream_of_or_withinISORGD:7337441624291 PMID:11986303RGDPMID:11986303
Prdx1Ratleukocyte activation involved_inIBAMGI:109486|PANTHER:PTN000743557|UniProtKB:Q06830|ZFIN:ZDB-GENE-050320-351600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1Ratnatural killer cell activation involved_inISORGD:7337441624291 PMID:8462106RGDPMID:8462106
Prdx1Ratnatural killer cell mediated cytotoxicity acts_upstream_of_or_withinISORGD:7337451624291MGI:2670538 PMID:12891360RGDPMID:12891360
Prdx1Ratregulation of non-canonical NF-kappaB signal transduction acts_upstream_of_negative_effectISORGD:7337451624291 PMID:15858817RGDPMID:15858817
Prdx1Ratregulation of stress-activated MAPK cascade acts_upstream_of_or_withinISORGD:7337451624291 PMID:16880205RGDPMID:16880205
Prdx1Ratremoval of superoxide radicals involved_inIBAMGI:109486|MGI:99523|PANTHER:PTN000743557|UniProtKB:P321191600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1Ratremoval of superoxide radicals acts_upstream_of_or_withinISORGD:7337451624291MGI:3611932 PMID:16170382, PMID:16880205RGDPMID:16170382|PMID:16880205
Prdx1Ratresponse to oxidative stress  IDA 2291828 RGD 
Prdx1Ratresponse to oxidative stress acts_upstream_of_or_withinISORGD:7337451624291 PMID:15858817, PMID:8360158RGDPMID:15858817|PMID:8360158
Prdx1Ratresponse to oxidative stress involved_inIBACGD:CAL0000174369|FB:FBgn0040308|FB:FBgn0040309|MGI:109486|MGI:1859815|MGI:88034|MGI:99523|PANTHER:PTN000073874|PomBase:SPCC576.03c|RGD:3838|RGD:620039|SGD:S000002861|SGD:S000004490|UniProtKB:P0AE08|UniProtKB:P0CU34|UniProtKB:P30048|UniProtKB:P32119|UniProtKB:Q8I5Q6|UniProtKB:Q8IL80|WB:WBGene000064341600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1Ratresponse to reactive oxygen species acts_upstream_of_or_withinISORGD:7337451624291MGI:2670538|MGI:3611932 PMID:12891360, PMID:16170382, PMID:16297875RGDPMID:12891360|PMID:16170382|PMID:16297875
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Cellular Component

  
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Prdx1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Prdx1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Prdx1Ratcytoplasm located_inISORGD:7337441624291 PMID:17603937RGDPMID:17603937
Prdx1Ratcytosol is_active_inIBAFB:FBgn0040308|FB:FBgn0040309|MGI:1859815|PANTHER:PTN000073874|SGD:S000004490|UniProtKB:P0AE08|UniProtKB:P30048|UniProtKB:Q8IL801600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1Rateuchromatin  IDA 2291802 RGD 
Prdx1Ratmitochondrial matrix  IDA 2291802 RGD 
Prdx1Ratnucleus located_inISORGD:7337441624291 PMID:17603937RGDPMID:17603937
Prdx1Ratperoxisomal matrix  IDA 2291802 RGD 

Molecular Function
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Prdx1Ratantioxidant activity enablesIEAUniProtKB-KW:KW-00491600115GO_REF:0000043UniProtGO_REF:0000043
Prdx1Ratantioxidant activity enablesIEAInterPro:IPR0008661600115GO_REF:0000002InterProGO_REF:0000002
Prdx1Ratheme binding  IPICHEBI:30413729570 RGD 
Prdx1Ratidentical protein binding  IPIRGD:6200392291799homodimerizationRGD 
Prdx1Ratidentical protein binding enablesISORGD:7337451624291UniProtKB:P35700 PMID:21516123RGDPMID:21516123
Prdx1Ratoxidoreductase activity enablesIEAInterPro:IPR0008661600115GO_REF:0000002InterProGO_REF:0000002
Prdx1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Prdx1Ratperoxidase activity enablesISORGD:7337441624291 PMID:11986303RGDPMID:11986303
Prdx1Ratperoxidase activity enablesIEAUniProtKB-KW:KW-05751600115GO_REF:0000043UniProtGO_REF:0000043
Prdx1Ratperoxiredoxin activity  IDA 2291801 RGD 
Prdx1Ratperoxiredoxin activity enablesIEAInterPro:IPR0194791600115GO_REF:0000002InterProGO_REF:0000002
Prdx1Ratperoxiredoxin activity  IDA 2291832 RGD 
Prdx1Ratprotein binding enablesISORGD:7337441624291UniProtKB:P04156|UniProtKB:P10275|UniProtKB:P13693|UniProtKB:P54274|UniProtKB:P58004|UniProtKB:P60484|UniProtKB:Q13043|UniProtKB:Q13162|UniProtKB:Q78TU8|UniProtKB:Q86TI2-2|UniProtKB:Q8N7X4|UniProtKB:Q9BYN0|UniProtKB:Q9Y6P5 PMID:15105503, PMID:17909037, PMID:18172504, PMID:19369943, PMID:21044950, PMID:21969592, PMID:21988832, PMID:23386615, PMID:27607350, PMID:28671123, PMID:32814053, PMID:33961781RGDPMID:15105503|PMID:17909037|PMID:18172504|PMID:19369943|PMID:21044950|PMID:21969592|PMID:21988832|PMID:23386615|PMID:27607350|PMID:28671123|PMID:32814053|PMID:33961781
Prdx1Ratprotein binding enablesISORGD:7337451624291UniProtKB:Q13043 PMID:21516123RGDPMID:21516123
Prdx1Ratthioredoxin peroxidase activity enablesISORGD:7337441624291 PMID:18606987RGDPMID:18606987
Prdx1Ratthioredoxin peroxidase activity enablesIBACGD:CAL0000174369|PANTHER:PTN000073874|PomBase:SPCC576.03c|SGD:S000002861|SGD:S000004490|UniProtKB:P0CU34|UniProtKB:P30048|UniProtKB:P32119|UniProtKB:Q06830|UniProtKB:Q8I5Q6|UniProtKB:Q8IL80|WB:WBGene000064341600115GO_REF:0000033GO_CentralGO_REF:0000033
Prdx1Ratthioredoxin-dependent peroxiredoxin activity enablesIEARHEA:626201600115GO_REF:0000116RHEAGO_REF:0000116
Prdx1Ratthioredoxin-dependent peroxiredoxin activity enablesIEAEC:1.11.1.241600115GO_REF:0000003UniProtGO_REF:0000003
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Reference Title
Reference Citation
1. In-depth identification of pathways related to cisplatin-induced hepatotoxicity through an integrative method based on an informatics-assisted label-free protein quantitation and microarray gene expression approach. Cho YE, etal., Mol Cell Proteomics. 2012 Jan;11(1):M111.010884. doi: 10.1074/mcp.M111.010884. Epub 2011 Oct 24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product. Hirotsu S, etal., Proc Natl Acad Sci U S A. 1999 Oct 26;96(22):12333-8.
5. Expression of the mRNA of heme-binding protein 23 is coordinated with that of heme oxygenase-1 by heme and heavy metals in primary rat hepatocytes and hepatoma cells. Immenschuh S, etal., Biochemistry 1995 Oct 17;34(41):13407-11.
6. Differential cellular and subcellular localization of heme-binding protein 23/peroxiredoxin I and heme oxygenase-1 in rat liver. Immenschuh S, etal., J Histochem Cytochem. 2003 Dec;51(12):1621-31.
7. Inhibition of the thiol-specific antioxidant activity of rat liver MSP23 protein by hemin. Ishii T, etal., Biochem Biophys Res Commun. 1995 Nov 22;216(3):970-5.
8. Purification, characterization, and cloning of a heme-binding protein (23 kDa) in rat liver cytosol. Iwahara S, etal., Biochemistry 1995 Oct 17;34(41):13398-406.
9. Rat lung peroxiredoxins I and II are differentially regulated during development and by hyperoxia. Kim HS, etal., Am J Physiol Lung Cell Mol Physiol. 2001 Jun;280(6):L1212-7.
10. Analysis of peroxiredoxin decreasing oxidative stress in hypertensive aortic smooth muscle. Lee CK, etal., Biochim Biophys Acta. 2007 Jul;1774(7):848-55. Epub 2007 May 10.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. GOA pipeline RGD automated data pipeline
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Cold acclimation reduces hepatic protein Kinase B and AMP-activated protein kinase phosphorylation and increases gluconeogenesis in Rats. Sepa-Kishi DM, etal., Physiol Rep. 2018 Mar;6(5). doi: 10.14814/phy2.13592.
16. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
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PMID:8360158   PMID:8462106   PMID:10514471   PMID:10751410   PMID:11986303   PMID:12891360   PMID:12960165   PMID:15448164   PMID:15489334   PMID:15858817   PMID:16170382   PMID:16297875  
PMID:16309569   PMID:16880205   PMID:17519234   PMID:17603937   PMID:17634366   PMID:17761673   PMID:17974571   PMID:18250162   PMID:18606987   PMID:18614015   PMID:19182904   PMID:19199708  
PMID:20458337   PMID:21516123   PMID:21630459   PMID:22166015   PMID:22658674   PMID:22664934   PMID:22681889   PMID:22871113   PMID:23106098   PMID:23376485   PMID:23533145   PMID:23580065  
PMID:23979707   PMID:24625528   PMID:25468996   PMID:25989822   PMID:26003307   PMID:26316108   PMID:26945066   PMID:27756681   PMID:27922677   PMID:29410271   PMID:29476059   PMID:31904090  
PMID:32292063   PMID:33682513   PMID:35352799  



Prdx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85135,383,906 - 135,399,504 (+)NCBIGRCr8
mRatBN7.25130,147,258 - 130,162,856 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5130,147,204 - 130,162,856 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5132,772,005 - 132,788,840 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05134,526,605 - 134,543,441 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05134,549,011 - 134,565,848 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05135,536,413 - 135,551,986 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5135,536,413 - 135,551,990 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05139,332,556 - 139,348,210 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45136,975,780 - 136,991,630 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15136,981,005 - 136,996,856 (+)NCBI
Celera5128,674,439 - 128,690,018 (+)NCBICelera
Cytogenetic Map5q35NCBI
PRDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38145,511,051 - 45,522,890 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl145,510,914 - 45,542,732 (-)EnsemblGRCh38hg38GRCh38
GRCh37145,976,723 - 45,988,562 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36145,749,294 - 45,760,196 (-)NCBINCBI36Build 36hg18NCBI36
Build 34145,645,800 - 45,656,702NCBI
Celera144,260,797 - 44,271,582 (-)NCBICelera
Cytogenetic Map1p34.1NCBI
HuRef144,088,373 - 44,099,940 (-)NCBIHuRef
CHM1_1146,093,972 - 46,105,688 (-)NCBICHM1_1
T2T-CHM13v2.0145,383,419 - 45,395,258 (-)NCBIT2T-CHM13v2.0
Prdx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394116,542,796 - 116,557,196 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4116,542,741 - 116,558,019 (+)EnsemblGRCm39 Ensembl
GRCm384116,685,599 - 116,700,000 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4116,685,544 - 116,700,822 (+)EnsemblGRCm38mm10GRCm38
MGSCv374116,358,204 - 116,372,605 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364116,183,531 - 116,197,932 (+)NCBIMGSCv36mm8
Celera4115,419,593 - 115,433,994 (+)NCBICelera
Cytogenetic Map4D1NCBI
cM Map453.28NCBI
Prdx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546412,761,401 - 12,773,146 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546412,761,390 - 12,773,413 (+)NCBIChiLan1.0ChiLan1.0
PRDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21181,286,968 - 181,297,925 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11180,428,500 - 180,439,413 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0144,813,508 - 44,824,430 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1146,171,453 - 46,182,018 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl146,171,453 - 46,182,018 (-)Ensemblpanpan1.1panPan2
PRDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11514,834,009 - 14,855,665 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1514,838,652 - 14,862,971 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1514,959,792 - 14,976,803 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01514,988,879 - 15,010,844 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1514,993,508 - 15,018,355 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11514,790,828 - 14,808,277 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01514,858,579 - 14,875,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01514,930,831 - 14,947,857 (+)NCBIUU_Cfam_GSD_1.0
Prdx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505860,816,994 - 60,828,561 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647426,639,259 - 26,653,328 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647426,641,776 - 26,653,291 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6165,824,395 - 165,861,442 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16165,847,390 - 165,859,918 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26153,253,841 - 153,265,947 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12087,267,026 - 87,277,634 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2087,267,044 - 87,279,978 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603329,683,931 - 29,694,719 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prdx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249061,405,253 - 1,414,926 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249061,405,253 - 1,414,980 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

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Variants in Prdx1
127 total Variants

Predicted Target Of
Summary Value
Count of predictions:164
Count of miRNA genes:120
Interacting mature miRNAs:130
Transcripts:ENSRNOT00000023132
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 52 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
1302790Scl20Serum cholesterol level QTL 206.40.0001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)582394392166664054Rat
1598861Cm64Cardiac mass QTL 642.9heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)5127798274166875058Rat
1578766Tcas11Tongue tumor susceptibility QTL 114.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)546711509161317411Rat
1549838Bss4Bone structure and strength QTL 49.2femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)5106906205151906205Rat

1 to 10 of 52 rows
RH127925  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map5q36UniSTS
Prdx1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,602,573 - 193,602,643 (+)MAPPERmRatBN7.2
mRatBN7.25130,154,646 - 130,156,228 (+)MAPPERmRatBN7.2
mRatBN7.25130,156,177 - 130,156,228 (+)MAPPERmRatBN7.2
Rnor_6.02208,738,546 - 208,738,615NCBIRnor6.0
Rnor_6.05135,543,785 - 135,545,366NCBIRnor6.0
Rnor_5.02228,162,502 - 228,162,571UniSTSRnor5.0
Rnor_5.05139,340,009 - 139,341,590UniSTSRnor5.0
RGSC_v3.45136,983,429 - 136,985,010UniSTSRGSC3.4
RGSC_v3.42201,373,781 - 201,373,850UniSTSRGSC3.4
Celera2186,293,818 - 186,293,887UniSTS
Celera5128,681,817 - 128,683,398UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map5q36UniSTS
UniSTS:470676  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22193,602,443 - 193,602,900 (+)MAPPERmRatBN7.2
mRatBN7.2647,072,314 - 47,072,784 (+)MAPPERmRatBN7.2
Rnor_6.0649,393,315 - 49,393,784NCBIRnor6.0
Rnor_6.02208,738,416 - 208,738,872NCBIRnor6.0
Rnor_5.0658,073,558 - 58,074,027UniSTSRnor5.0
Rnor_5.02228,162,372 - 228,162,828UniSTSRnor5.0
RGSC_v3.42201,373,651 - 201,374,107UniSTSRGSC3.4
RGSC_v3.4648,332,780 - 48,333,249UniSTSRGSC3.4
Celera646,276,343 - 46,276,812UniSTS
Celera2186,293,688 - 186,294,144UniSTS
Cytogenetic Map2q34UniSTS
Cytogenetic Map6q16UniSTS
Cytogenetic Map5q36UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000023132   ⟹   ENSRNOP00000023132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5130,147,204 - 130,162,856 (+)Ensembl
Rnor_6.0 Ensembl5135,536,413 - 135,551,990 (+)Ensembl
RefSeq Acc Id: NM_057114   ⟹   NP_476455
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85135,383,906 - 135,399,504 (+)NCBI
mRatBN7.25130,147,258 - 130,162,856 (+)NCBI
Rnor_6.05135,536,413 - 135,551,986 (+)NCBI
Rnor_5.05139,332,556 - 139,348,210 (+)NCBI
RGSC_v3.45136,975,780 - 136,991,630 (+)RGD
Celera5128,674,439 - 128,690,018 (+)RGD
Sequence:
Protein RefSeqs NP_476455 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH58450 (Get FASTA)   NCBI Sequence Viewer  
  AAH88118 (Get FASTA)   NCBI Sequence Viewer  
  BAA06275 (Get FASTA)   NCBI Sequence Viewer  
  EDL90264 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000023132
  ENSRNOP00000023132.2
GenBank Protein Q63716 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476455   ⟸   NM_057114
- UniProtKB: Q63716 (UniProtKB/Swiss-Prot),   A6JZ89 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000023132   ⟸   ENSRNOT00000023132
Thioredoxin

Name Modeler Protein Id AA Range Protein Structure
AF-Q63716-F1-model_v2 AlphaFold Q63716 1-199 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693938
Promoter ID:EPDNEW_R4463
Type:multiple initiation site
Name:Prdx1_1
Description:peroxiredoxin 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05135,536,393 - 135,536,453EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40242 BioCyc
Ensembl Genes ENSRNOG00000017194 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023132 ENTREZGENE
  ENSRNOT00000023132.6 UniProtKB/Swiss-Prot
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920987 IMAGE-MGC_LOAD
  IMAGE:7324630 IMAGE-MGC_LOAD
InterPro AhpC/TSA UniProtKB/Swiss-Prot
  Peroxiredoxin UniProtKB/Swiss-Prot
  Peroxiredoxin_AhpC-typ UniProtKB/Swiss-Prot
  Peroxiredoxin_C UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:117254 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108617 IMAGE-MGC_LOAD
  MGC:72725 IMAGE-MGC_LOAD
NCBI Gene 117254 ENTREZGENE
PANTHER PEROXIREDOXIN-1 UniProtKB/Swiss-Prot
  THIOREDOXIN PEROXIDASE UniProtKB/Swiss-Prot
Pfam 1-cysPrx_C UniProtKB/Swiss-Prot
  AhpC-TSA UniProtKB/Swiss-Prot
PhenoGen Prdx1 PhenoGen
PIRSF AHPC UniProtKB/Swiss-Prot
PROSITE THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017194 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
UniProt A6JZ89 ENTREZGENE, UniProtKB/TrEMBL
  PRDX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Prdx1  peroxiredoxin 1      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Prdx1  peroxiredoxin 1      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_regulation mRNA expression is induced by heavy metals CdCl2 and CoCl2 729465