Gclm (glutamate cysteine ligase, modifier subunit) - Rat Genome Database

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Gene: Gclm (glutamate cysteine ligase, modifier subunit) Rattus norvegicus
Analyze
Symbol: Gclm
Name: glutamate cysteine ligase, modifier subunit
RGD ID: 619871
Description: Enables glutamate-cysteine ligase activity and glutamate-cysteine ligase catalytic subunit binding activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to hepatocyte growth factor stimulus; and cellular response to thyroxine stimulus. Part of glutamate-cysteine ligase complex. Human ortholog(s) of this gene implicated in myocardial infarction and vascular dementia. Orthologous to human GCLM (glutamate-cysteine ligase modifier subunit); PARTICIPATES IN glutathione metabolic pathway; 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; INTERACTS WITH (R)-lipoic acid; (R,R,R)-alpha-tocopherol; 1,1'-azobis(N,N-dimethylformamide).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gamma-ECS regulatory subunit; gamma-glutamylcysteine synthetase regulatory subunit; GCS light chain; Glclr; glutamate cysteine ligase (gamma-glutamylcysteine synthetase) regulatory; glutamate cysteine ligase (gamma-glutamylcysteine synthetase), regulatory; glutamate cysteine ligase modifier subunit; glutamate--cysteine ligase modifier subunit; glutamate--cysteine ligase regulatory subunit; glutamate-cysteine ligase modifier subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,032,135 - 213,052,192 (+)NCBIGRCr8
mRatBN7.22210,347,482 - 210,367,537 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,347,482 - 210,367,535 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,020,579 - 218,040,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,928,345 - 215,948,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,770,305 - 210,790,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,827,504 - 225,847,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,827,504 - 225,847,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,862,903 - 243,883,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,895,434 - 218,915,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12218,858,495 - 218,878,551 (+)NCBI
Celera2202,777,122 - 202,797,150 (+)NCBICelera
Cytogenetic Map2q42NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
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Original Reference(s)
GclmRatLiver Injury  IEP 10402380mRNA:decreased expression:liver:RGD 
GclmRatTubulointerstitial Fibrosis  IEP 5134352 RGD 
GclmRatvascular dementia susceptibilityISOGCLM (Homo sapiens)10402374associated with stroke and DNA:polymorphism:promoter:-588C>T(human)RGD 
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Original Reference(s)
GclmRatmyocardial infarction  ISOGCLM (Homo sapiens)8554872ClinVar Annotator: match by term: Myocardial infarction and susceptibility toClinVarPMID:12081989 and PMID:12975258
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Original Reference(s)
GclmRatberylliosis  ISOGCLM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16766924
GclmRatChemical and Drug Induced Liver Injury  ISOGCLM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249
GclmRatmyocardial infarction  ISOGCLM (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12081989 and PMID:12975258
GclmRattype 2 diabetes mellitus  ISOGCLM (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:32715377
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Original Reference(s)
GclmRatmyocardial infarction susceptibilityISOGCLM (Homo sapiens)7240710 OMIM 

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Original Reference(s)
GclmRat(-)-demecolcine decreases expressionISOGCLM (Homo sapiens)6480464Demecolcine results in decreased expression of GCLM mRNACTDPMID:23649840
GclmRat(-)-epigallocatechin 3-gallate increases expressionISOGclm (Mus musculus)6480464epigallocatechin gallate results in increased expression of GCLM mRNACTDPMID:25585349
GclmRat(E)-cinnamyl alcohol increases expressionISOGCLM (Homo sapiens)6480464cinnamyl alcohol results in increased expression of GCLM mRNACTDPMID:20566472 more ...
GclmRat(R)-lipoic acid increases expressionISOGCLM (Homo sapiens)6480464Thioctic Acid results in increased expression of GCLM mRNA and Thioctic Acid results in increased expression of GCLM proteinCTDPMID:16249512 and PMID:26365678
GclmRat(R)-lipoic acid multiple interactionsISOGCLM (Homo sapiens)6480464Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM mRNA] and Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLM protein]CTDPMID:26365678
GclmRat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM mRNA] and Thioctic Acid inhibits the reaction [methylmercuric chloride results in increased expression of GCLM protein]CTDPMID:32061141
GclmRat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GCLM mRNA]CTDPMID:22389237
GclmRat(R,R,R)-alpha-tocopherol multiple interactionsISOGCLM (Homo sapiens)6480464[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLM mRNACTDPMID:24530478
GclmRat(S)-colchicine multiple interactionsISOGclm (Mus musculus)6480464Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]CTDPMID:37573684
GclmRat(S)-naringenin increases expressionISOGCLM (Homo sapiens)6480464naringenin results in increased expression of GCLM proteinCTDPMID:31254498
GclmRat(S)-naringenin multiple interactionsISOGCLM (Homo sapiens)6480464NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLM protein]CTDPMID:31254498
GclmRat1,1'-azobis(N,N-dimethylformamide) increases expressionEXP 6480464Diamide results in increased expression of GCLM mRNA and Diamide results in increased expression of GCLM proteinCTDPMID:15115889
GclmRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of GCLM mRNACTDPMID:17984292
GclmRat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionISOGclm (Mus musculus)6480464o and p'-DDT affects the expression of GCLM mRNACTDPMID:18925944
GclmRat1,1-dichloroethene decreases expressionISOGclm (Mus musculus)6480464vinylidene chloride results in decreased expression of GCLM mRNACTDPMID:26682919
GclmRat1,2-dimethylhydrazine affects expressionISOGclm (Mus musculus)64804641 and 2-Dimethylhydrazine affects the expression of GCLM mRNACTDPMID:22206623
GclmRat1,3-benzothiazole-2-thiol increases expressionISOGCLM (Homo sapiens)6480464captax results in increased expression of GCLM mRNACTDPMID:23999411 and PMID:24211530
GclmRat1,3-dichloropropan-2-ol increases expressionEXP 64804641 and 3-dichloro-2-propanol results in increased expression of GCLM mRNACTDPMID:26143167
GclmRat1,4-benzoquinone increases expressionISOGCLM (Homo sapiens)6480464quinone results in increased expression of GCLM proteinCTDPMID:21059386
GclmRat1,4-phenylenediamine increases expressionISOGCLM (Homo sapiens)64804644-phenylenediamine results in increased expression of GCLM mRNACTDPMID:16314067 more ...

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Biological Process
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GclmRatapoptotic mitochondrial changes acts_upstream_of_or_withinIEAUniProtKB:O09172 and ensembl:ENSMUSP000000297691600115GO_REF:0000107EnsemblGO_REF:0000107
GclmRatapoptotic mitochondrial changes acts_upstream_of_or_withinISOGclm (Mus musculus)1624291MGI:104990 PMID:15288121RGDPMID:15288121
GclmRatblood vessel diameter maintenance involved_inISSUniProtKB:P485071600115GO_REF:0000024UniProtGO_REF:0000024
GclmRatblood vessel diameter maintenance involved_inIEAUniProtKB:P48507 and ensembl:ENSP000003592581600115GO_REF:0000107EnsemblGO_REF:0000107
GclmRatblood vessel diameter maintenance involved_inISOGCLM (Homo sapiens)1624291 PMID:12975258RGDPMID:12975258
GclmRatcellular response to fibroblast growth factor stimulus  IEP 10402377 RGD 
GclmRatcellular response to follicle-stimulating hormone stimulus  IEP 10402377 RGD 
GclmRatcellular response to glucose stimulus  IEP 10402379 RGD 
GclmRatcellular response to hepatocyte growth factor stimulus  IEP 10402379 RGD 
GclmRatcellular response to leukemia inhibitory factor acts_upstream_of_or_withinISOGclm (Mus musculus)1624291 PMID:20439489RGDPMID:20439489
GclmRatcellular response to leukemia inhibitory factor acts_upstream_of_or_withinIEAUniProtKB:O09172 and ensembl:ENSMUSP000000297691600115GO_REF:0000107EnsemblGO_REF:0000107
GclmRatcellular response to thyroxine stimulus  IEP 10402376 RGD 
GclmRatcysteine metabolic process acts_upstream_of_or_withinIEAUniProtKB:O09172 and ensembl:ENSMUSP000000297691600115GO_REF:0000107EnsemblGO_REF:0000107
GclmRatcysteine metabolic process acts_upstream_of_or_withinISOGclm (Mus musculus)1624291MGI:2447852 PMID:12384496RGDPMID:12384496
GclmRatglutamate metabolic process involved_inISSUniProtKB:P485071600115GO_REF:0000024UniProtGO_REF:0000024
GclmRatglutamate metabolic process involved_inIEAUniProtKB:P48507 and ensembl:ENSP000003592581600115GO_REF:0000107EnsemblGO_REF:0000107
GclmRatglutamate metabolic process involved_inISOGCLM (Homo sapiens)1624291 PMID:9841880 and PMID:9895302RGDPMID:9841880 and PMID:9895302
GclmRatglutathione biosynthetic process  IMP 1582661 RGD 
GclmRatglutathione biosynthetic process involved_inIEAUniProtKB-KW:KW-03171600115GO_REF:0000043UniProtGO_REF:0000043
GclmRatglutathione biosynthetic process involved_inIEAUniProtKB:P48507 and ensembl:ENSP000003592581600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component

  

Molecular Function
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Original Reference(s)
GclmRatglutamate-cysteine ligase activity  IDA 632762 RGD 
GclmRatglutamate-cysteine ligase activity contributes_toIEAUniProtKB:P48507 and ensembl:ENSP000003592581600115GO_REF:0000107EnsemblGO_REF:0000107
GclmRatglutamate-cysteine ligase activity contributes_toISOGCLM (Homo sapiens)1624291 PMID:16183645RGDPMID:16183645
GclmRatglutamate-cysteine ligase activity contributes_toIMP 1582661 RGD 
GclmRatglutamate-cysteine ligase catalytic subunit binding  IDA 1582663 RGD 
GclmRatglutamate-cysteine ligase catalytic subunit binding enablesIEAUniProtKB:O09172 and ensembl:ENSMUSP000000297691600115GO_REF:0000107EnsemblGO_REF:0000107
GclmRatglutamate-cysteine ligase catalytic subunit binding enablesISOGclm (Mus musculus)1624291 PMID:12384496RGDPMID:12384496
GclmRatglutamate-cysteine ligase catalytic subunit binding enablesIEAInterPro:IPR0329631600115GO_REF:0000002InterProGO_REF:0000002
GclmRatglutamate-cysteine ligase catalytic subunit binding enablesIBAFB:FBgn0046114 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
GclmRatglutamate-cysteine ligase catalytic subunit binding enablesIEAUniProtKB:P48507 and ensembl:ENSP000003592581600115GO_REF:0000107EnsemblGO_REF:0000107
GclmRatglutamate-cysteine ligase catalytic subunit binding enablesISOGCLM (Homo sapiens)1624291UniProtKB:P48506 more ...RGDPMID:9675072 and PMID:9841880
GclmRatglutamate-cysteine ligase catalytic subunit binding enablesISSUniProtKB:P485071600115GO_REF:0000024UniProtGO_REF:0000024
GclmRatglutamate-cysteine ligase regulator activity enablesIBAFB:FBgn0046114 and PANTHER:PTN0003291441600115GO_REF:0000033GO_CentralGO_REF:0000033
GclmRatprotein binding enablesISOGCLM (Homo sapiens)1624291UniProtKB:P48506 more ...RGDPMID:28514442 more ...
GclmRatprotein binding enablesISOGclm (Mus musculus)1624291PR:P97494 PMID:12384496 and PMID:16081425RGDPMID:12384496 and PMID:16081425
GclmRatprotein-containing complex binding  IDA 1582663heterodimerizationRGD 
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RGD Manual Annotations


  
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Original Reference(s)
GclmRatglutathione metabolic pathway  IDA 1582663 RGD 
GclmRatglutathione metabolic pathway  IMP 1582661 RGD 

Imported Annotations - KEGG (archival)

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Original Reference(s)
GclmRatglutathione metabolic pathway  IEA 6907045 KEGGrno:00480

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#
Reference Title
Reference Citation
1. Polymorphisms and vascular cognitive impairment after ischemic stroke. Baum L, etal., J Geriatr Psychiatry Neurol. 2007 Jun;20(2):93-9.
2. Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. Chen CN, etal., J Gerontol A Biol Sci Med Sci. 2010 Feb;65(2):129-37. doi: 10.1093/gerona/glp194. Epub 2009 Dec 16.
3. Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs. Dasgupta A, etal., Free Radic Biol Med. 2007 Mar 1;42(5):617-26. Epub 2006 Dec 15.
4. Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons. Diaz-Hernandez JI, etal., J Biol Chem. 2005 Nov 25;280(47):38992-9001. Epub 2005 Sep 23.
5. Curvature of clathrin-coated pits driven by epsin. Ford MG, etal., Nature 2002 Sep 26;419(6905):361-6.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells. Gualtieri AF, etal., Int J Androl. 2009 Jun;32(3):218-25. Epub 2007 Nov 27.
9. Amino acid sequence and function of the light subunit of rat kidney gamma-glutamylcysteine synthetase. Huang CS, etal., J Biol Chem 1993 Sep 25;268(27):20578-83.
10. HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA. Hui L, etal., Free Radic Biol Med. 2010 Aug 1;49(3):467-73. doi: 10.1016/j.freeradbiomed.2010.05.002. Epub 2010 May 11.
11. Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats. Jang HI, etal., Nutr Res Pract. 2014 Jun;8(3):272-7. doi: 10.4162/nrp.2014.8.3.272. Epub 2014 May 15.
12. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
13. Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. Lee JI, etal., Biochem J. 2006 Jan 1;393(Pt 1):181-90.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
16. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Mechanism and significance of changes in glutamate-cysteine ligase expression during hepatic fibrogenesis. Ramani K, etal., J Biol Chem. 2012 Oct 19;287(43):36341-55. doi: 10.1074/jbc.M112.370775. Epub 2012 Aug 31.
20. GOA pipeline RGD automated data pipeline
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PMID:9675072   PMID:9841880   PMID:9895302   PMID:10395918   PMID:12081989   PMID:12384496   PMID:12975258   PMID:15288121   PMID:15489334   PMID:16081425   PMID:20439489   PMID:20447326  
PMID:24557597   PMID:27998794  



Gclm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82213,032,135 - 213,052,192 (+)NCBIGRCr8
mRatBN7.22210,347,482 - 210,367,537 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2210,347,482 - 210,367,535 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2218,020,579 - 218,040,873 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02215,928,345 - 215,948,639 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02210,770,305 - 210,790,599 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02225,827,504 - 225,847,876 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2225,827,504 - 225,847,874 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02243,862,903 - 243,883,275 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42218,895,434 - 218,915,491 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12218,858,495 - 218,878,551 (+)NCBI
Celera2202,777,122 - 202,797,150 (+)NCBICelera
Cytogenetic Map2q42NCBI
GCLM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38193,885,199 - 93,909,430 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl193,885,199 - 93,909,456 (-)EnsemblGRCh38hg38GRCh38
GRCh37194,350,755 - 94,374,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36194,125,178 - 94,147,600 (-)NCBINCBI36Build 36hg18NCBI36
Build 34194,064,610 - 94,087,033NCBI
Celera192,606,277 - 92,628,698 (-)NCBICelera
Cytogenetic Map1p22.1NCBI
HuRef192,473,642 - 92,495,998 (-)NCBIHuRef
CHM1_1194,467,558 - 94,489,979 (-)NCBICHM1_1
T2T-CHM13v2.0193,733,450 - 93,757,695 (-)NCBIT2T-CHM13v2.0
Gclm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393122,039,206 - 122,060,864 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3122,039,206 - 122,064,381 (+)EnsemblGRCm39 Ensembl
GRCm383122,245,487 - 122,267,215 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3122,245,557 - 122,270,732 (+)EnsemblGRCm38mm10GRCm38
MGSCv373121,948,510 - 121,969,566 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363122,237,614 - 122,258,670 (+)NCBIMGSCv36mm8
MGSCv363122,610,732 - 122,631,895 (+)NCBIMGSCv36mm8
Celera3128,652,324 - 128,663,438 (+)NCBICelera
Cytogenetic Map3G1NCBI
cM Map352.94NCBI
Gclm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955423782,468 - 805,384 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955423782,468 - 805,384 (+)NCBIChiLan1.0ChiLan1.0
GCLM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21133,110,998 - 133,133,736 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11132,267,567 - 132,291,710 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0196,548,850 - 96,573,273 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1195,278,665 - 95,298,854 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl195,278,665 - 95,297,893 (-)Ensemblpanpan1.1panPan2
GCLM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1655,204,602 - 55,244,217 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha657,930,482 - 57,952,133 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0655,598,315 - 55,619,977 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl655,598,408 - 55,617,490 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1655,278,061 - 55,299,711 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0655,263,100 - 55,284,829 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0655,715,747 - 55,737,399 (+)NCBIUU_Cfam_GSD_1.0
LOC101977655
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405058103,569,105 - 103,591,072 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365375,356,914 - 5,378,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCLM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4123,371,193 - 123,390,131 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14123,371,198 - 123,390,130 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24135,017,027 - 135,035,890 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCLM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12039,339,948 - 39,359,980 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2039,339,908 - 39,359,430 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603378,685,244 - 78,710,789 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gclm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247423,713,250 - 3,743,290 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247423,713,275 - 3,746,219 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gclm
131 total Variants

Predicted Target Of
Summary Value
Count of predictions:66
Count of miRNA genes:55
Interacting mature miRNAs:62
Transcripts:ENSRNOT00000018343
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 47 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat

1 to 10 of 47 rows
RH127880  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,366,861 - 210,367,043 (+)MAPPERmRatBN7.2
Rnor_6.02225,847,201 - 225,847,382NCBIRnor6.0
Rnor_5.02243,882,600 - 243,882,781UniSTSRnor5.0
RGSC_v3.42218,914,816 - 218,914,997UniSTSRGSC3.4
Celera2202,796,475 - 202,796,656UniSTS
RH 3.4 Map21501.9UniSTS
Cytogenetic Map2q41UniSTS
RH129590  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,367,720 - 210,367,922 (+)MAPPERmRatBN7.2
Rnor_6.02225,848,060 - 225,848,261NCBIRnor6.0
Rnor_5.02243,883,459 - 243,883,660UniSTSRnor5.0
RGSC_v3.42218,915,675 - 218,915,876UniSTSRGSC3.4
Celera2202,797,334 - 202,797,535UniSTS
RH 3.4 Map21520.6UniSTS
Cytogenetic Map2q41UniSTS
RH94669  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22210,367,151 - 210,367,337 (+)MAPPERmRatBN7.2
Rnor_6.02225,847,491 - 225,847,676NCBIRnor6.0
Rnor_5.02243,882,890 - 243,883,075UniSTSRnor5.0
RGSC_v3.42218,915,106 - 218,915,291UniSTSRGSC3.4
Celera2202,796,765 - 202,796,950UniSTS
Cytogenetic Map2q41UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000018343   ⟹   ENSRNOP00000018343
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2210,347,482 - 210,367,535 (+)Ensembl
Rnor_6.0 Ensembl2225,827,504 - 225,847,874 (+)Ensembl
RefSeq Acc Id: NM_017305   ⟹   NP_059001
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82213,032,135 - 213,052,192 (+)NCBI
mRatBN7.22210,347,482 - 210,367,537 (+)NCBI
Rnor_6.02225,827,504 - 225,847,876 (+)NCBI
Rnor_5.02243,862,903 - 243,883,275 (+)NCBI
RGSC_v3.42218,895,434 - 218,915,491 (+)RGD
Celera2202,777,122 - 202,797,150 (+)RGD
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_059001 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41543 (Get FASTA)   NCBI Sequence Viewer  
  AAB28225 (Get FASTA)   NCBI Sequence Viewer  
  AAH78867 (Get FASTA)   NCBI Sequence Viewer  
  AAR06178 (Get FASTA)   NCBI Sequence Viewer  
  ABB96114 (Get FASTA)   NCBI Sequence Viewer  
  EDL82095 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000018343
  ENSRNOP00000018343.3
GenBank Protein P48508 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_059001   ⟸   NM_017305
- UniProtKB: P48508 (UniProtKB/Swiss-Prot),   A6HVF9 (UniProtKB/TrEMBL),   Q2VC85 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018343   ⟸   ENSRNOT00000018343
NADP-dependent oxidoreductase

Name Modeler Protein Id AA Range Protein Structure
AF-P48508-F1-model_v2 AlphaFold P48508 1-274 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691722
Promoter ID:EPDNEW_R2247
Type:initiation region
Name:Gclm_1
Description:glutamate cysteine ligase, modifier subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02225,827,478 - 225,827,538EPDNEW


1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51379 BioCyc
BioCyc Pathway GLUTATHIONESYN-PWY [glutathione biosynthesis] BioCyc
BioCyc Pathway Image GLUTATHIONESYN-PWY BioCyc
Ensembl Genes ENSRNOG00000013409 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018343 ENTREZGENE
  ENSRNOT00000018343.5 UniProtKB/Swiss-Prot
Gene3D-CATH 3.20.20.100 UniProtKB/Swiss-Prot
InterPro Gclm UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom UniProtKB/Swiss-Prot
  NADP_OxRdtase_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:29739 UniProtKB/Swiss-Prot
NCBI Gene 29739 ENTREZGENE
PANTHER GLUTAMATE--CYSTEINE LIGASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PTHR13295 UniProtKB/Swiss-Prot
Pfam Aldo_ket_red UniProtKB/Swiss-Prot
PhenoGen Gclm PhenoGen
RatGTEx ENSRNOG00000013409 RatGTEx
Superfamily-SCOP SSF51430 UniProtKB/Swiss-Prot
TIGR TC229541
UniProt A6HVF9 ENTREZGENE, UniProtKB/TrEMBL
  GSH0_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2VC85 ENTREZGENE, UniProtKB/TrEMBL
  Q71S94_RAT UniProtKB/TrEMBL
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2003-04-09 Gclm  glutamate cysteine ligase, modifier subunit      Symbol and Name updated 629477 APPROVED
2003-03-14 Gclm  glutamate cysteine ligase, modifier subunit  Glclr  Glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory  Data merged from RGD:2701 628472 PROVISIONAL
2002-08-07 Gclm        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Glclr  Glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), regulatory      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_protein 274 amino acids; 30.5 kDa 632726