Gclc (glutamate-cysteine ligase, catalytic subunit) - Rat Genome Database

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Gene: Gclc (glutamate-cysteine ligase, catalytic subunit) Rattus norvegicus
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Symbol: Gclc
Name: glutamate-cysteine ligase, catalytic subunit
RGD ID: 619868
Description: Enables glutamate-cysteine ligase activity. Involved in several processes, including cellular response to follicle-stimulating hormone stimulus; cellular response to hepatocyte growth factor stimulus; and cellular response to mechanical stimulus. Part of glutamate-cysteine ligase complex. Used to study liver cirrhosis and pulmonary emphysema. Human ortholog(s) of this gene implicated in congenital nonspherocytic hemolytic anemia 7; cystic fibrosis; hemolytic anemia; and myocardial infarction. Orthologous to human GCLC (glutamate-cysteine ligase catalytic subunit); PARTICIPATES IN glutathione metabolic pathway; 2-hydroxyglutaric aciduria pathway; cysteine metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,1'-azobis(N,N-dimethylformamide).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: gamma-ECS; gamma-glutamylcysteine synthetase; GCS heavy chain; Glclc; glutamate--cysteine ligase catalytic subunit; glutamate-cysteine ligase catalytic subunit; Glutamylcysteine gamma synthetase light chain; MGC93096
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,510,251 - 87,548,896 (+)NCBIGRCr8
mRatBN7.2878,629,899 - 78,668,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,117,437 - 84,155,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,394,078 - 82,432,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,216,769 - 80,255,182 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Celera878,379,669 - 78,418,088 (+)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
GclcRatChemical and Drug Induced Liver Injury  IMP 10402383 RGD 
GclcRatcolorectal cancer  ISORGD:73679311049536mRNA:increased expression:colon:RGD 
GclcRatcystic fibrosis  ISORGD:7367935134682 RGD 
GclcRatGram-Negative Bacterial Infections susceptibilityISORGD:73679310401929associated with Cystic Fibrosis;DNA:SNP,haplotype:promoter:-129C >T,-3506A >G (human)RGD 
GclcRathemolytic anemia  ISORGD:73679311049537DNA:missense mutation:cds: 473C>T (p.158L)(human)RGD 
GclcRatliver cirrhosis  IMP 11049542 RGD 
GclcRatLiver Injury treatmentIEP 10402380mRNA:decreased expression:liver:RGD 
GclcRatmyocardial infarction  ISORGD:7367931302515DNA:snp:promoter:c.-129C>T (human)RGD 
GclcRatpulmonary emphysema  IDA 5134681 RGD 
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GclcRatcongenital nonspherocytic hemolytic anemia 7  ISORGD:7367938554872ClinVar Annotator: match by term: Gamma-glutamylcysteine synthetase deficiencyClinVarPMID:10515893|PMID:10733484|PMID:25741868|PMID:28492532|PMID:5901982
GclcRatgenetic disease  ISORGD:7367938554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532
GclcRatmyocardial infarction  ISORGD:7367938554872ClinVar Annotator: match by term: GCLC-related condition | ClinVar Annotator: match by term: Myocardial infarction, more ...ClinVarPMID:12598062|PMID:25741868|PMID:28492532
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GclcRatamino acid metabolic disorder  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:10515893
GclcRatChemical and Drug Induced Liver Injury  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:19481141
GclcRatcongenital nonspherocytic hemolytic anemia 7  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTD 
GclcRatcontact dermatitis  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
GclcRatCoronary Vessel Anomalies  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:12598062
GclcRathemolytic anemia  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:10515893
GclcRathypertension  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:22228705
GclcRatLung Neoplasms  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:27935865
GclcRatlung non-small cell carcinoma  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:15496427
GclcRatmicrophthalmia  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:35123994
GclcRatmyocardial infarction  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:12598062
GclcRatMyocardial Ischemia  ISORGD:73679311554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
GclcRatNeoplastic Cell Transformation  ISORGD:73679311554173CTD Direct Evidence: therapeuticCTDPMID:30940545
GclcRattype 2 diabetes mellitus  ISORGD:73679311554173CTD Direct Evidence: therapeuticCTDPMID:32715377
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GclcRatcataract  ISSRGD:1065213592920OMIM:601371MouseDO 
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GclcRatcongenital nonspherocytic hemolytic anemia 7 susceptibilityISORGD:7367937240710 OMIM 
GclcRatmyocardial infarction susceptibilityISORGD:7367937240710 OMIM 

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GclcRat(+)-catechin multiple interactionsISORGD:7367936480464[Oxygen deficiency co-treated with Catechin] results in increased expression of GCLC mRNACTDPMID:35883890
GclcRat(+)-schisandrin B increases activityEXP 6480464schizandrin B analog results in increased activity of GCLC proteinCTDPMID:21328628
GclcRat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GCLC mRNA]CTDPMID:31150632
GclcRat(+/-)-Aegeline multiple interactionsISORGD:106526480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with more ...CTDPMID:28843594
GclcRat(-)-epigallocatechin 3-gallate increases expressionISORGD:106526480464epigallocatechin gallate results in increased expression of GCLC mRNACTDPMID:25585349
GclcRat(-)-epigallocatechin 3-gallate multiple interactionsISORGD:7367936480464[arsenite co-treated with epigallocatechin gallate] results in increased expression of GCLC proteinCTDPMID:29572906
GclcRat(1->4)-beta-D-glucan multiple interactionsISORGD:106526480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GCLC mRNACTDPMID:36331819
GclcRat(2,4,5-trichlorophenoxy)acetic acid increases expressionISORGD:73679364804642,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC mRNACTDPMID:16426233
GclcRat(2,4,5-trichlorophenoxy)acetic acid increases expressionISORGD:1065264804642,4,5-Trichlorophenoxyacetic Acid results in increased expression of GCLC; 2,4,5-Trichlorophenoxyacetic Acid results in increased expression of more ...CTDPMID:10377250|PMID:16426233
GclcRat(E)-cinnamyl alcohol increases expressionISORGD:7367936480464cinnamyl alcohol results in increased expression of GCLC mRNACTDPMID:20566472
GclcRat(R)-lipoic acid increases expressionISORGD:7367936480464Thioctic Acid results in increased expression of GCLC mRNACTDPMID:16249512|PMID:17940886|PMID:26365678
GclcRat(R)-lipoic acid multiple interactionsISORGD:7367936480464Thioctic Acid promotes the reaction [Cadmium Chloride results in increased expression of GCLC mRNA]; Thioctic more ...CTDPMID:26365678
GclcRat(R)-lipoic acid multiple interactionsISORGD:106526480464Thioctic Acid inhibits the reaction [Silicon results in decreased expression of GCLC protein]CTDPMID:34252510
GclcRat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [methylmercuric chloride results in decreased expression of GCLC protein]; Thioctic more ...CTDPMID:27298056|PMID:32061141
GclcRat(R,R,R)-alpha-tocopherol multiple interactionsISORGD:7367936480464[alpha-Tocopherol co-treated with Paraquat] results in increased expression of GCLC mRNACTDPMID:24530478
GclcRat(RS)-coclaurine multiple interactionsISORGD:106526480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with more ...CTDPMID:28843594
GclcRat(RS)-norcoclaurine multiple interactionsISORGD:106526480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with more ...CTDPMID:28843594
GclcRat(S)-coclaurine multiple interactionsISORGD:106526480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with more ...CTDPMID:28843594
GclcRat(S)-colchicine multiple interactionsISORGD:106526480464Colchicine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]CTDPMID:37573684
GclcRat(S)-naringenin multiple interactionsISORGD:7367936480464NFE2L2 protein affects the reaction [naringenin results in increased expression of GCLC protein]CTDPMID:31254498

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Biological Process
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Original Reference(s)
GclcRatblood vessel diameter maintenance involved_inISSUniProtKB:P485061600115GO_REF:0000024UniProtGO_REF:0000024
GclcRatblood vessel diameter maintenance involved_inIEAUniProtKB:P48506|ensembl:ENSP000004975741600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatblood vessel diameter maintenance involved_inISORGD:7367931624291 PMID:12598062RGDPMID:12598062
GclcRatcell redox homeostasis involved_inISSUniProtKB:P485061600115GO_REF:0000024UniProtGO_REF:0000024
GclcRatcell redox homeostasis involved_inIEAUniProtKB:P48506|ensembl:ENSP000004975741600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatcell redox homeostasis involved_inISORGD:7367931624291 PMID:10439045RGDPMID:10439045
GclcRatcellular response to fibroblast growth factor stimulus  IEP 10402377 RGD 
GclcRatcellular response to follicle-stimulating hormone stimulus  IEP 10402377 RGD 
GclcRatcellular response to glucose stimulus  IEP 10402379 RGD 
GclcRatcellular response to hepatocyte growth factor stimulus  IEP 10402379 RGD 
GclcRatcellular response to insulin stimulus  IEP 10402381 RGD 
GclcRatcellular response to mechanical stimulus  IEP 8547898 RGD 
GclcRatcellular response to thyroxine stimulus  IEP 10402376 RGD 
GclcRatcysteine metabolic process involved_inISSUniProtKB:P485061600115GO_REF:0000024UniProtGO_REF:0000024
GclcRatcysteine metabolic process involved_inIEAUniProtKB:P48506|ensembl:ENSP000004975741600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatcysteine metabolic process involved_inISORGD:7367931624291 PMID:2294991RGDPMID:2294991
GclcRatglutamate metabolic process involved_inISSUniProtKB:P485061600115GO_REF:0000024UniProtGO_REF:0000024
GclcRatglutamate metabolic process involved_inIEAUniProtKB:P48506|ensembl:ENSP000004975741600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatglutamate metabolic process involved_inISORGD:7367931624291 PMID:12663448, PMID:2294991, PMID:9841880RGDPMID:12663448|PMID:2294991|PMID:9841880
GclcRatglutathione biosynthetic process  IMP 1582661 RGD 
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Cellular Component
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GclcRatcytosol located_inISORGD:106521624291 PMID:12384496RGDPMID:12384496
GclcRatcytosol located_inIEAUniProtKB:P97494|ensembl:ENSMUSP000000349051600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatglutamate-cysteine ligase complex  IDA 1582663 RGD 
GclcRatglutamate-cysteine ligase complex part_ofIEAUniProtKB:P48506|ensembl:ENSP000004975741600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatglutamate-cysteine ligase complex part_ofISORGD:106521624291 PMID:12384496RGDPMID:12384496
GclcRatglutamate-cysteine ligase complex part_ofIBAFB:FBgn0040319|MGI:104990|PANTHER:PTN000126117|RGD:619868|UniProtKB:P485061600115GO_REF:0000033GO_CentralGO_REF:0000033
GclcRatglutamate-cysteine ligase complex part_ofIEAUniProtKB:P97494|ensembl:ENSMUSP000000349051600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatglutamate-cysteine ligase complex part_ofISORGD:7367931624291 PMID:9675072, PMID:9841880RGDPMID:9675072|PMID:9841880
GclcRatmitochondrion located_inIEAGO:19010291600115GO_REF:0000108GOCGO_REF:0000108
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Molecular Function
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GclcRatADP binding enablesISSUniProtKB:P485061600115GO_REF:0000024UniProtGO_REF:0000024
GclcRatADP binding enablesIEAUniProtKB:P48506|ensembl:ENSP000004975741600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatADP binding enablesISORGD:7367931624291 PMID:24639RGDPMID:24639
GclcRatATP binding enablesIEAUniRule:UR0014537981600115GO_REF:0000104UniProtGO_REF:0000104
GclcRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
GclcRatcatalytic activity enablesIEAInterPro:IPR0147461600115GO_REF:0000002InterProGO_REF:0000002
GclcRatglutamate binding enablesISSUniProtKB:P485061600115GO_REF:0000024UniProtGO_REF:0000024
GclcRatglutamate binding enablesIEAUniProtKB:P48506|ensembl:ENSP000004975741600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatglutamate binding enablesISORGD:7367931624291 PMID:9841880RGDPMID:9841880
GclcRatglutamate-cysteine ligase activity  IMP 1582661 RGD 
GclcRatglutamate-cysteine ligase activity enablesIEARHEA:132851600115GO_REF:0000116RHEAGO_REF:0000116
GclcRatglutamate-cysteine ligase activity enablesIEAEC:6.3.2.21600115GO_REF:0000003UniProtGO_REF:0000003
GclcRatglutamate-cysteine ligase activity enablesISORGD:106521624291MGI:2429419 PMID:10966520, PMID:11118286, PMID:12384496, PMID:15288121, PMID:16081425RGDPMID:10966520|PMID:11118286|PMID:12384496|PMID:15288121|PMID:16081425
GclcRatglutamate-cysteine ligase activity enablesIBAFB:FBgn0040319|MGI:104990|PANTHER:PTN000126115|PomBase:SPAC22F3.10c|RGD:619868|SGD:S000003637|UniProtKB:P48506|dictyBase:DDB_G02846511600115GO_REF:0000033GO_CentralGO_REF:0000033
GclcRatglutamate-cysteine ligase activity enablesIEAUniProtKB:P97494|ensembl:ENSMUSP000000349051600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatglutamate-cysteine ligase activity enablesIEAUniProtKB:P48506|ensembl:ENSP000004975741600115GO_REF:0000107EnsemblGO_REF:0000107
GclcRatglutamate-cysteine ligase activity enablesISORGD:7367931624291 PMID:11972604, PMID:12663448, PMID:16183645, PMID:8104187, PMID:9675072, PMID:9841880RGDPMID:11972604|PMID:12663448|PMID:16183645|PMID:8104187|PMID:9675072|PMID:9841880
GclcRatglutamate-cysteine ligase activity enablesIEAInterPro:IPR0043081600115GO_REF:0000002InterProGO_REF:0000002
GclcRatglutamate-cysteine ligase activity enablesISSUniProtKB:P485061600115GO_REF:0000024UniProtGO_REF:0000024
GclcRatglutamate-cysteine ligase activity enablesIEAUniRule:UR0014537981600115GO_REF:0000104UniProtGO_REF:0000104
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RGD Manual Annotations


  
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Original Reference(s)
GclcRatglutathione metabolic pathway  IDA 1582663 RGD 
GclcRatglutathione metabolic pathway  IMP 1582661 RGD 

Imported Annotations - SMPDB

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GclcRat2-hydroxyglutaric aciduria pathway  ISORGD:73679310402751 SMPDBSMP:00136
GclcRatcysteine metabolic pathway  ISORGD:73679310402751 SMPDBSMP:00013
GclcRatglutamic acid/glutamate metabolic pathway  ISORGD:73679310402751 SMPDBSMP:00072
GclcRatglutathione metabolic pathway  ISORGD:73679310402751 SMPDBSMP:00015
GclcRatglutathione synthase deficiency pathway  ISORGD:73679310402751 SMPDBSMP:00143
GclcRatglutathione synthase deficiency pathway  ISORGD:73679310402751 SMPDBSMP:00337
GclcRatglutathionuria disease pathway  ISORGD:73679310402751 SMPDBSMP:00501
GclcRathomocarnosinosis pathway  ISORGD:73679310402751 SMPDBSMP:00385
GclcRatmercaptolactate-cysteine disulfiduria pathway  ISORGD:73679310402751 SMPDBSMP:00499
GclcRatocular nonnephropathic cystinosis pathway  ISORGD:73679310402751 SMPDBSMP:00722
GclcRatsuccinic semialdehyde dehydrogenase deficiency pathway  ISORGD:73679310402751 SMPDBSMP:00243
GclcRatsuccinic semialdehyde dehydrogenase deficiency pathway  ISORGD:73679310402751 SMPDBSMP:00567
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Imported Annotations - KEGG (archival)

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GclcRatglutathione metabolic pathway  IEA 6907045 KEGGrno:00480

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Reference Title
Reference Citation
1. Knock down of gamma-glutamylcysteine synthetase in rat causes acetaminophen-induced hepatotoxicity. Akai S, etal., J Biol Chem. 2007 Aug 17;282(33):23996-4003. Epub 2007 Jun 15.
2. Gamma-glutamylcysteine synthetase deficiency and hemolytic anemia. Beutler E, etal., Blood 1990 Jan 1;75(1):271-3.
3. The molecular basis of a case of gamma-glutamylcysteine synthetase deficiency. Beutler E, etal., Blood 1999 Oct 15;94(8):2890-4.
4. Aging impairs the expression of the catalytic subunit of glutamate cysteine ligase in soleus muscle under stress. Chen CN, etal., J Gerontol A Biol Sci Med Sci. 2010 Feb;65(2):129-37. doi: 10.1093/gerona/glp194. Epub 2009 Dec 16.
5. Thyroid hormone promotes glutathione synthesis in astrocytes by up regulation of glutamate cysteine ligase through differential stimulation of its catalytic and modulator subunit mRNAs. Dasgupta A, etal., Free Radic Biol Med. 2007 Mar 1;42(5):617-26. Epub 2006 Dec 15.
6. Knockdown of glutamate-cysteine ligase by small hairpin RNA reveals that both catalytic and modulatory subunits are essential for the survival of primary neurons. Diaz-Hernandez JI, etal., J Biol Chem. 2005 Nov 25;280(47):38992-9001. Epub 2005 Sep 23.
7. Stable transfection of Chinese hamster ovary cells with glutamate-cysteine ligase catalytic subunit cDNA confers increased resistance to tert-butyl hydroperoxide toxicity. Fernandes CJ, etal., Toxicol Lett. 2002 Dec 15;136(2):107-20.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. FSH and bFGF stimulate the production of glutathione in cultured rat Sertoli cells. Gualtieri AF, etal., Int J Androl. 2009 Jun;32(3):218-25. Epub 2007 Nov 27.
11. HGF suppresses high glucose-mediated oxidative stress in mesangial cells by activation of PKG and inhibition of PKA. Hui L, etal., Free Radic Biol Med. 2010 Aug 1;49(3):467-73. doi: 10.1016/j.freeradbiomed.2010.05.002. Epub 2010 May 11.
12. Schisandra Chinensis Baillon regulates the gene expression of phase II antioxidant/detoxifying enzymes in hepatic damage induced rats. Jang HI, etal., Nutr Res Pract. 2014 Jun;8(3):272-7. doi: 10.4162/nrp.2014.8.3.272. Epub 2014 May 15.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. Insulin signaling regulates gamma-glutamylcysteine ligase catalytic subunit expression in primary cultured rat hepatocytes. Kim SK, etal., J Pharmacol Exp Ther. 2004 Oct;311(1):99-108. Epub 2004 May 28.
15. Association of polymorphism in glutamate-cysteine ligase catalytic subunit gene with coronary vasomotor dysfunction and myocardial infarction. Koide S, etal., J Am Coll Cardiol 2003 Feb 19;41(4):539-45.
16. Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Kuo MT, etal., Cancer Res. 1996 Aug 15;56(16):3642-4.
17. Differential regulation of glutamate-cysteine ligase subunit expression and increased holoenzyme formation in response to cysteine deprivation. Lee JI, etal., Biochem J. 2006 Jan 1;393(Pt 1):181-90.
18. Polymorphisms in the glutathione pathway modulate cystic fibrosis severity: a cross-sectional study. Marson FA, etal., BMC Med Genet. 2014 Mar 4;15:27. doi: 10.1186/1471-2350-15-27.
19. Variants in the glutamate-cysteine-ligase gene are associated with cystic fibrosis lung disease. McKone EF, etal., Am J Respir Crit Care Med. 2006 Aug 15;174(4):415-9. Epub 2006 May 11.
20. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
1 to 20 of 40 rows
PMID:24639   PMID:8104187   PMID:9675072   PMID:9841880   PMID:10395918   PMID:10439045   PMID:10805773   PMID:10966520   PMID:11118286   PMID:11972604   PMID:12384496   PMID:12663448  
PMID:12784246   PMID:12967637   PMID:15288121   PMID:15489334   PMID:15988009   PMID:16081425   PMID:16198230   PMID:16758951   PMID:17045015   PMID:17189825   PMID:17681938   PMID:17721935  
PMID:19459163   PMID:19540342   PMID:20732396   PMID:20732852   PMID:21984568   PMID:23682816   PMID:25016074   PMID:27998794  



Gclc
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8887,510,251 - 87,548,896 (+)NCBIGRCr8
mRatBN7.2878,629,899 - 78,668,547 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,117,437 - 84,155,850 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,394,078 - 82,432,491 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,216,769 - 80,255,182 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,059,051 - 85,097,471 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0884,627,768 - 84,666,188 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4882,724,429 - 82,762,848 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1882,743,482 - 82,781,899 (+)NCBI
Celera878,379,669 - 78,418,088 (+)NCBICelera
Cytogenetic Map8q31NCBI
GCLC
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38653,497,341 - 53,545,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl653,497,341 - 53,616,970 (-)EnsemblGRCh38hg38GRCh38
GRCh37653,362,139 - 53,409,899 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36653,470,098 - 53,517,790 (-)NCBINCBI36Build 36hg18NCBI36
Build 34653,470,097 - 53,517,790NCBI
Celera655,024,301 - 55,071,990 (-)NCBICelera
Cytogenetic Map6p12.1NCBI
HuRef653,193,712 - 53,241,391 (-)NCBIHuRef
CHM1_1653,363,932 - 53,411,726 (-)NCBICHM1_1
T2T-CHM13v2.0653,337,262 - 53,388,129 (-)NCBIT2T-CHM13v2.0
Gclc
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39977,661,817 - 77,701,771 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl977,661,817 - 77,701,767 (+)EnsemblGRCm39 Ensembl
GRCm38977,754,535 - 77,794,489 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl977,754,535 - 77,794,485 (+)EnsemblGRCm38mm10GRCm38
MGSCv37977,602,617 - 77,641,458 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36977,540,494 - 77,579,335 (+)NCBIMGSCv36mm8
Celera974,927,826 - 74,966,687 (+)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.36NCBI
Gclc
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554112,593,541 - 2,616,539 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554112,593,523 - 2,617,553 (+)NCBIChiLan1.0ChiLan1.0
GCLC
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2567,968,397 - 68,019,315 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1663,844,833 - 63,895,670 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0653,052,145 - 53,102,794 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1654,687,315 - 54,738,111 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl654,687,315 - 54,734,994 (-)Ensemblpanpan1.1panPan2
GCLC
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,999,815 - 21,047,779 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1221,000,792 - 21,047,779 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,898,243 - 20,947,109 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01221,495,557 - 21,544,499 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1221,496,624 - 21,545,459 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11220,996,643 - 21,045,520 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01221,104,936 - 21,153,860 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01221,243,198 - 21,292,135 (-)NCBIUU_Cfam_GSD_1.0
Gclc
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494656,541,439 - 56,588,950 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364767,371,149 - 7,418,958 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364767,371,270 - 7,418,756 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GCLC
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl727,209,565 - 27,253,530 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1727,209,565 - 27,253,535 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2731,702,759 - 31,747,437 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GCLC
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11719,012,994 - 19,060,617 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1719,013,026 - 19,060,659 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604453,368,286 - 53,415,900 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gclc
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624850749,050 - 793,959 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624850749,046 - 793,654 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gclc
274 total Variants

Predicted Target Of
Summary Value
Count of predictions:452
Count of miRNA genes:236
Interacting mature miRNAs:290
Transcripts:ENSRNOT00000033196
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 57 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat

1 to 10 of 57 rows
RH128816  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2878,668,270 - 78,668,474 (+)MAPPERmRatBN7.2
Rnor_6.0885,097,195 - 85,097,398NCBIRnor6.0
Rnor_5.0884,665,912 - 84,666,115UniSTSRnor5.0
RGSC_v3.4882,762,572 - 82,762,775UniSTSRGSC3.4
Celera878,417,812 - 78,418,015UniSTS
RH 3.4 Map8923.9UniSTS
Cytogenetic Map8q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000033196   ⟹   ENSRNOP00000035540
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)Ensembl
Rnor_6.0 Ensembl885,059,051 - 85,097,468 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000119398   ⟹   ENSRNOP00000081649
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl878,630,127 - 78,668,544 (+)Ensembl
RefSeq Acc Id: NM_012815   ⟹   NP_036947
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,510,476 - 87,548,896 (+)NCBI
mRatBN7.2878,630,127 - 78,668,547 (+)NCBI
Rnor_6.0885,059,051 - 85,097,471 (+)NCBI
Rnor_5.0884,627,768 - 84,666,188 (+)NCBI
RGSC_v3.4882,724,429 - 82,762,848 (+)RGD
Celera878,379,669 - 78,418,088 (+)RGD
Sequence:
RefSeq Acc Id: XM_039080870   ⟹   XP_038936798
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,510,251 - 87,541,472 (+)NCBI
mRatBN7.2878,629,899 - 78,661,120 (+)NCBI
RefSeq Acc Id: XM_063264945   ⟹   XP_063121015
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8887,528,434 - 87,548,896 (+)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_036947 (Get FASTA)   NCBI Sequence Viewer  
  XP_038936798 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121015 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41208 (Get FASTA)   NCBI Sequence Viewer  
  AAH81702 (Get FASTA)   NCBI Sequence Viewer  
  EDL77759 (Get FASTA)   NCBI Sequence Viewer  
  EDL77760 (Get FASTA)   NCBI Sequence Viewer  
  EDL77761 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000035540
  ENSRNOP00000035540.3
GenBank Protein P19468 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_036947   ⟸   NM_012815
- UniProtKB: P19468 (UniProtKB/Swiss-Prot),   A6I1G6 (UniProtKB/TrEMBL),   A0A8I5ZU55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000035540   ⟸   ENSRNOT00000033196
RefSeq Acc Id: XP_038936798   ⟸   XM_039080870
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000081649   ⟸   ENSRNOT00000119398
RefSeq Acc Id: XP_063121015   ⟸   XM_063264945
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZU55 (UniProtKB/TrEMBL)

Name Modeler Protein Id AA Range Protein Structure
AF-P19468-F1-model_v2 AlphaFold P19468 1-637 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 23 of 23 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29780 BioCyc
BioCyc Pathway GLUTATHIONESYN-PWY [glutathione biosynthesis] BioCyc
BioCyc Pathway Image GLUTATHIONESYN-PWY BioCyc
Ensembl Genes ENSRNOG00000006302 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000033196 ENTREZGENE
  ENSRNOT00000033196.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.8.960 UniProtKB/Swiss-Prot
  3.30.590.50 UniProtKB/Swiss-Prot
InterPro GCS UniProtKB/Swiss-Prot
  Gln_synth/guanido_kin_cat_dom UniProtKB/Swiss-Prot
KEGG Report rno:25283 UniProtKB/Swiss-Prot
NCBI Gene 25283 ENTREZGENE
PANTHER GLUTAMATE--CYSTEINE LIGASE CATALYTIC SUBUNIT UniProtKB/Swiss-Prot
  PTHR11164 UniProtKB/Swiss-Prot
Pfam GCS UniProtKB/Swiss-Prot
PhenoGen Gclc PhenoGen
RatGTEx ENSRNOG00000006302 RatGTEx
Superfamily-SCOP SSF55931 UniProtKB/Swiss-Prot
UniProt A0A8I5ZU55 ENTREZGENE, UniProtKB/TrEMBL
  A6I1G6 ENTREZGENE, UniProtKB/TrEMBL
  A6I1G7_RAT UniProtKB/TrEMBL
  A6I1G8_RAT UniProtKB/TrEMBL
  GSH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 23 of 23 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gclc  glutamate-cysteine ligase, catalytic subunit    glutamate-cysteine ligase catalytic subunit  Name updated 1299863 APPROVED
2003-04-09 Gclc  glutamate-cysteine ligase catalytic subunit      Symbol and Name updated 629477 APPROVED
2003-03-14 Gclc  glutamate-cysteine ligase catalytic subunit  Glclc  Glutamylcysteine gamma synthetase light chain  Data merged from RGD:2700 628472 PROVISIONAL
2002-08-07 Gclc        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Glclc  Glutamylcysteine gamma synthetase light chain      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expression reduced in response to some types of liver damage 70249
gene_protein 637 amino acids; 72.6 kDA 632745