Rac1 (Rac family small GTPase 1) - Rat Genome Database

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Gene: Rac1 (Rac family small GTPase 1) Rattus norvegicus
Analyze
Symbol: Rac1
Name: Rac family small GTPase 1
RGD ID: 619755
Description: Enables several functions, including GTP binding activity; Rho GDP-dissociation inhibitor binding activity; and enzyme binding activity. Involved in several processes, including actin cytoskeleton organization; bone resorption; and positive regulation of plasma membrane bounded cell projection assembly. Located in Golgi membrane and cytosol. Is active in GABA-ergic synapse. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 48; colorectal cancer (multiple); lung cancer; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; Arf family mediated signaling pathway; azathioprine pharmacodynamics pathway; INTERACTS WITH 11-deoxycorticosterone; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: p21-Rac1; ras-related C3 botulinum toxin substrate 1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1); ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); rho family, small GTP binding protein Rac1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,150,411 - 16,170,864 (+)NCBIGRCr8
mRatBN7.21211,037,028 - 11,057,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,036,698 - 11,057,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,844,100 - 11,864,510 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,467,387 - 12,487,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,492,647 - 11,513,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Rac1Ratbreast cancer  ISORAC1 (Homo sapiens)155230815protein:increased expression:breast (human)RGD 
Rac1Ratbreast cancer exacerbatesISORAC1 (Homo sapiens)153323321protein:increased expression:breast (human)RGD 
Rac1RatCardiomegaly  ISORac1 (Mus musculus)1581293 RGD 
Rac1RatCardiomegaly  ISORac1 (Mus musculus)1581294 RGD 
Rac1Ratcolon adenocarcinoma  ISORAC1 (Homo sapiens)13432049mRNA:alternative formRGD 
Rac1Ratcolon adenocarcinoma treatmentISORAC1 (Homo sapiens)13432051 RGD 
Rac1Ratcolon adenoma  ISORAC1 (Homo sapiens)13432048 RGD 
Rac1Ratcolorectal adenocarcinoma disease_progressionISORAC1 (Homo sapiens)155230818mRNA and protein:increased expression:colorectum (human)RGD 
Rac1Ratcolorectal cancer disease_progressionISORAC1 (Homo sapiens)13432050mRNA:alternative formRGD 
Rac1Ratcolorectal cancer amelioratesISORAC1 (Homo sapiens)152998911human cell line in a mouse modelRGD 
Rac1Ratcolorectal cancer  ISORAC1 (Homo sapiens)13432052 RGD 
Rac1Ratcolorectal carcinoma exacerbatesISORAC1 (Homo sapiens)153298972protein:increased expression:colorectum (human)RGD 
Rac1Ratcolorectal carcinoma exacerbatesISORAC1 (Homo sapiens)153350139protein:increased activity:colorectal mucosa (human)RGD 
Rac1Ratcolorectal carcinoma amelioratesISORAC1 (Homo sapiens)153350124human cell line in a mouse modelRGD 
Rac1Ratcongestive heart failure  IAGP 1581295 RGD 
Rac1Ratextrahepatic bile duct adenocarcinoma  ISORAC1 (Homo sapiens)153350126protein:increased expression:mucosa (human)RGD 
Rac1Ratgallbladder carcinoma exacerbatesISORAC1 (Homo sapiens)155230819protein:increased expression:gallbladder (human)RGD 
Rac1Ratgastric adenocarcinoma exacerbatesISORAC1 (Homo sapiens)153300951protein:increased expression:stomach (human)RGD 
Rac1Rathepatocellular carcinoma exacerbatesISORAC1 (Homo sapiens)153350129protein:increased expression:liver (human)RGD 
Rac1Rathepatocellular carcinoma exacerbatesISORAC1 (Homo sapiens)153298967mRNA:increased expression:liver (human)RGD 
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Rac1Ratautosomal dominant intellectual developmental disorder 48  ISORAC1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 more ...
Rac1RatDevelopmental Disabilities  ISORAC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVarPMID:25741868 more ...
Rac1RatDevelopmental Disease  ISORAC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:25741868
Rac1Ratgenetic disease  ISORAC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVar 
Rac1Ratneurodevelopmental disorder with dysmorphic facies and distal limb anomalies  ISORAC1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorder with dysmorphic facies and distal limb anomaliesClinVarPMID:25741868 and PMID:28886345
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Rac1RatCardiotoxicity  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28710503
Rac1Ratcongestive heart failure  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16155095
Rac1Ratdiabetes mellitus  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23723366
Rac1Ratdilated cardiomyopathy  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16155095
Rac1Rathepatocellular carcinoma  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18506888
Rac1Ratliver disease  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17058265
Rac1Ratmelanoma  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22842228
Rac1RatNeoplasm Metastasis  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18506888
Rac1RatNeoplastic Cell Transformation  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22011395
Rac1RatVentricular Dysfunction, Left  ISORAC1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28710503
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Rac1Ratautosomal dominant intellectual developmental disorder 48  ISORAC1 (Homo sapiens)7240710 OMIM 

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Rac1Rat(+)-catechin decreases expressionISORAC1 (Homo sapiens)6480464Catechin results in decreased expression of RAC1 mRNACTDPMID:15465739
Rac1Rat(-)-epigallocatechin 3-gallate multiple interactionsISORAC1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of RAC1 mRNACTDPMID:22079256
Rac1Rat(1->4)-beta-D-glucan multiple interactionsISORac1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of RAC1 mRNACTDPMID:36331819
Rac1Rat1,2-dimethylhydrazine decreases expressionISORac1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of RAC1 mRNACTDPMID:22206623
Rac1Rat1,2-dimethylhydrazine multiple interactionsISORac1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of RAC1 mRNACTDPMID:22206623
Rac1Rat1,8-cineole multiple interactionsISORac1 (Mus musculus)6480464Eucalyptol inhibits the reaction [Glucose results in increased expression of RAC1 protein] and Eucalyptol inhibits the reaction [LEP gene mutant form results in increased expression of RAC1 protein]CTDPMID:31483951
Rac1Rat11-deoxycorticosterone multiple interactionsEXP 6480464[Desoxycorticosterone co-treated with Sodium Chloride] results in increased expression of RAC1 proteinCTDPMID:22431579
Rac1Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of RAC1 proteinCTDPMID:24231043
Rac1Rat17beta-estradiol increases expressionISORAC1 (Homo sapiens)6480464Estradiol results in increased expression of RAC1 mRNACTDPMID:23094148
Rac1Rat17beta-estradiol multiple interactionsISORAC1 (Homo sapiens)6480464IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of RAC1 mRNA]CTDPMID:23094148
Rac1Rat17beta-estradiol multiple interactionsEXP 6480464Dizocilpine Maleate inhibits the reaction [Estradiol results in increased expression of RAC1 protein] and U 0126 inhibits the reaction [Estradiol results in increased expression of RAC1 protein]CTDPMID:24231043
Rac1Rat2,2',4,4',5,5'-hexachlorobiphenyl increases phosphorylationISORAC1 (Homo sapiens)64804642 more ...CTDPMID:19632255
Rac1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORac1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of RAC1 mRNACTDPMID:21570461 and PMID:24680724
Rac1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of RAC1 mRNACTDPMID:34747641
Rac1Rat2,4,6-tribromophenol decreases expressionISORAC1 (Homo sapiens)64804642 more ...CTDPMID:31675489
Rac1Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of RAC1 mRNACTDPMID:21346803
Rac1Rat2-acetamidofluorene increases activityISORAC1 (Homo sapiens)64804642-Acetylaminofluorene results in increased activity of RAC1 proteinCTDPMID:11960367
Rac1Rat2-acetamidofluorene multiple interactionsISORAC1 (Homo sapiens)6480464[2-Acetylaminofluorene results in increased activity of RAC1 protein] which results in increased expression of ABCB1 mRNACTDPMID:11960367
Rac1Rat2-trans,6-trans,10-trans-geranylgeranyl diphosphate multiple interactionsISORAC1 (Homo sapiens)6480464geranylgeranyl pyrophosphate inhibits the reaction [Atorvastatin inhibits the reaction [Glucose results in increased localization of RAC1 protein]] more ...CTDPMID:17279352 and PMID:18625914
Rac1Rat2-trans,6-trans-farnesyl diphosphate multiple interactionsISORAC1 (Homo sapiens)6480464farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased activity of RAC1 protein]] and farnesyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased localization of RAC1 protein]]CTDPMID:18625914

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Biological Process
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Rac1Ratactin cytoskeleton organization  IDA 1599401 RGD 
Rac1Ratactin cytoskeleton organization acts_upstream_of_or_withinISORAC1 (Homo sapiens)1624291UniProtKB:P17105 and PMID:19890013RGDPMID:19890013
Rac1Ratactin filament organization  IMP 4145648 RGD 
Rac1Ratactin filament organization involved_inIBAFB:FBgn0010333 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rac1Ratactin filament organization involved_inISORAC1 (Homo sapiens)1624291 PMID:22796473RGDPMID:22796473
Rac1Ratactin filament organization involved_inISSUniProtKB:P630001600115GO_REF:0000024UniProtGO_REF:0000024
Rac1Ratactin filament polymerization acts_upstream_of_or_withinISORac1 (Mus musculus)1624291 PMID:22750946RGDPMID:22750946
Rac1Ratanatomical structure arrangement acts_upstream_of_or_withinISORac1 (Mus musculus)1624291MGI:2663662 more ...RGDPMID:20016102
Rac1Ratangiotensin-activated signaling pathway involved in heart process acts_upstream_of_or_withinISORac1 (Mus musculus)1624291 PMID:26975711RGDPMID:26975711
Rac1Ratauditory receptor cell morphogenesis acts_upstream_of_or_withinISORac1 (Mus musculus)1624291MGI:2663662 more ...RGDPMID:20016102
Rac1Rataxon guidance acts_upstream_of_or_withinISORac1 (Mus musculus)1624291MGI:1932522 more ...RGDPMID:17409253
Rac1Ratbone resorption  IDA 1599401 RGD 
Rac1Ratcell adhesion acts_upstream_of_or_withinISORac1 (Mus musculus)1624291 PMID:14657280RGDPMID:14657280
Rac1Ratcell chemotaxis involved_inIBAPANTHER:PTN008604698 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rac1Ratcell migration involved_inISORAC1 (Homo sapiens)1624291 PMID:23512198 and PMID:26934001RGDPMID:23512198 and PMID:26934001
Rac1Ratcell migration acts_upstream_of_or_withinISORac1 (Mus musculus)1624291 PMID:15728191RGDPMID:15728191
Rac1Ratcell motility involved_inISORAC1 (Homo sapiens)1624291 PMID:19403692RGDPMID:19403692
Rac1Ratcell motility involved_inISSUniProtKB:P630001600115GO_REF:0000024UniProtGO_REF:0000024
Rac1Ratcell projection assembly involved_inIBAFB:FBgn0010333 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rac1Ratcell-cell junction organization acts_upstream_of_or_withinISORac1 (Mus musculus)1624291MGI:2663662 more ...RGDPMID:20016102
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Cellular Component
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Rac1Ratactin filament located_inISORAC1 (Homo sapiens)1624291 PMID:19625648RGDPMID:19625648
Rac1Ratcell cortex located_inISORAC1 (Homo sapiens)1624291 PMID:19126672RGDPMID:19126672
Rac1Ratcell projection is_active_inIBAFB:FBgn0010333 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rac1Ratcell projection located_inISORac1 (Mus musculus)1624291 PMID:15728722RGDPMID:15728722
Rac1Ratcell projection located_inIEAUniProtKB-KW:KW-09661600115GO_REF:0000043UniProtGO_REF:0000043
Rac1Ratcytoplasm located_inISORAC1 (Homo sapiens)1624291 PMID:19625648RGDPMID:19625648
Rac1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Rac1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Rac1Ratcytoplasm located_inISORac1 (Mus musculus)1624291 PMID:12213441 and PMID:25074804RGDPMID:12213441 and PMID:25074804
Rac1Ratcytoplasmic ribonucleoprotein granule located_inISORAC1 (Homo sapiens)1624291 PMID:15121898RGDPMID:15121898
Rac1Ratcytoplasmic vesicle is_active_inIBAMGI:97845 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rac1Ratcytoplasmic vesicle located_inISORac1 (Mus musculus)1624291 PMID:12783890 and PMID:14516655RGDPMID:12783890 and PMID:14516655
Rac1Ratcytoskeleton is_active_inIBAMGI:97845 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rac1Ratcytosol located_inIDA 8554409PMID:20696765UniProt 
Rac1Ratdendrite located_inIEAUniProtKB-SubCell:SL-02831600115GO_REF:0000044UniProtGO_REF:0000044
Rac1Ratearly endosome membrane located_inISORac1 (Mus musculus)1624291 PMID:25074804RGDPMID:25074804
Rac1RatGABA-ergic synapse is_active_inEXP 13702191PMID:25284783SynGO 
Rac1RatGABA-ergic synapse is_active_inIDA 13702191PMID:25284783SynGO 
Rac1RatGABA-ergic synapse is_active_inIMP 13702191PMID:25284783SynGO 
Rac1Ratglutamatergic synapse is_active_inISORAC1 (Homo sapiens)1624291 PMID:15800193 and PMID:24352656RGDPMID:15800193 and PMID:24352656
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Molecular Function
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Rac1RatATPase binding  IPIAtp7a (Rattus norvegicus)11341707 RGD 
Rac1Ratenzyme binding enablesISORAC1 (Homo sapiens)1624291UniProtKB:Q9Y5S8 and PMID:16636067RGDPMID:16636067
Rac1RatG protein activity enablesISORac1 (Mus musculus)1624291EC:3.6.5.2 PMID:17058265 more ...RGDPMID:17058265 more ...
Rac1RatG protein activity enablesIEAEC:3.6.5.21600115GO_REF:0000003UniProtGO_REF:0000003
Rac1RatGTP binding  IDA 2314386 RGD 
Rac1RatGTP binding  IDA 704329 RGD 
Rac1RatGTP binding enablesISORac1 (Mus musculus)1624291 PMID:12783890 more ...RGDPMID:12783890 more ...
Rac1RatGTP binding enablesIEAUniProtKB-KW:KW-03421600115GO_REF:0000043UniProtGO_REF:0000043
Rac1RatGTP binding enablesIBACGD:CAL0000192612 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rac1RatGTP binding enablesIEAInterPro:IPR001806 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Rac1RatGTP binding enablesISORAC1 (Homo sapiens)1624291 PMID:12551911 more ...RGDPMID:12551911 more ...
Rac1RatGTP-dependent protein binding enablesISORac1 (Mus musculus)1624291UniProtKB:Q9Z101 and PMID:10954424RGDPMID:10954424
Rac1RatGTPase activity enablesISORAC1 (Homo sapiens)1624291 PMID:19787194 and PMID:27917469RGDPMID:19787194 and PMID:27917469
Rac1RatGTPase activity  IDA 704329 RGD 
Rac1RatGTPase activity enablesIEARHEA:196691600115GO_REF:0000116RHEAGO_REF:0000116
Rac1RatGTPase activity enablesISORac1 (Mus musculus)1624291 PMID:10699171 more ...RGDPMID:10699171 more ...
Rac1RatGTPase activity enablesIBACGD:CAL0000184710 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Rac1RatGTPase activity enablesIEAInterPro:IPR0018061600115GO_REF:0000002InterProGO_REF:0000002
Rac1Rathistone deacetylase binding  IPIHdac3 (Rattus norvegicus)9590167 RGD 
Rac1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Imported Annotations - PID (archival)

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Rac1RatArf family mediated signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200195
Rac1RatE-cadherin signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200124
Rac1RatE-cadherin signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200147
Rac1Rateicosanoid signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200082
Rac1Ratendothelin signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200005
Rac1Ratephrin - ephrin receptor bidirectional signaling axis  ISORAC1 (Homo sapiens)6484113 PIDPID:200204
Rac1Ratephrin - ephrin receptor bidirectional signaling axis  ISORAC1 (Homo sapiens)6484113 PIDPID:200052
Rac1Ratephrin - ephrin receptor bidirectional signaling axis  ISORAC1 (Homo sapiens)6484113 PIDPID:200216
Rac1Ratinterleukin-6 signaling pathway   ISORAC1 (Homo sapiens)6484113 PIDPID:200146
Rac1RatmTOR signaling pathway   ISORAC1 (Homo sapiens)6484113 PIDPID:200096
Rac1RatN-cadherin signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200209
Rac1Ratp38 MAPK signaling pathway   ISORAC1 (Homo sapiens)6484113 PIDPID:200018
Rac1Ratphosphatidylinositol 3-kinase class I signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200116
Rac1Ratplatelet-derived growth factor signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200149
Rac1Ratsphingosine 1-phosphate signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200046
Rac1Ratsphingosine 1-phosphate signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200085
Rac1Ratsphingosine 1-phosphate signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200211
Rac1Ratsyndecan signaling pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200134
Rac1RatWnt signaling, non-canonical pathway  ISORAC1 (Homo sapiens)6484113 PIDPID:200020
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Reference Title
Reference Citation
1. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2. RAC1b overexpression correlates with poor prognosis in KRAS/BRAF WT metastatic colorectal cancer patients treated with first-line FOLFOX/XELOX chemotherapy. Alonso-Espinaco V, etal., Eur J Cancer. 2014 Jul;50(11):1973-81. doi: 10.1016/j.ejca.2014.04.019. Epub 2014 May 12.
3. Ras-related C3 botulinum toxin substrate 1 (RAC1) regulates glucose-stimulated insulin secretion via modulation of F-actin. Asahara S, etal., Diabetologia. 2013 May;56(5):1088-97. doi: 10.1007/s00125-013-2849-5. Epub 2013 Feb 15.
4. Unexpected role of the copper transporter ATP7A in PDGF-induced vascular smooth muscle cell migration. Ashino T, etal., Circ Res. 2010 Sep 17;107(6):787-99. doi: 10.1161/CIRCRESAHA.110.225334. Epub 2010 Jul 29.
5. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer KL, etal., Mol Biol Cell. 1998 Mar;9(3):561-73.
6. Inhibition of growth and migration of cholangiocarcinoma cells by pamidronate. Buranrat B, etal., Exp Ther Med. 2019 Nov;18(5):3977-3983. doi: 10.3892/etm.2019.8041. Epub 2019 Sep 23.
7. A bibenzyl from Dendrobium ellipsophyllum inhibits migration in lung cancer cells. Chaotham C and Chanvorachote P, J Nat Med. 2015 Oct;69(4):565-74. doi: 10.1007/s11418-015-0925-5. Epub 2015 Jun 25.
8. Cytosol-derived proteins are sufficient for Arp2/3 recruitment and ARF/coatomer-dependent actin polymerization on Golgi membranes. Chen JL, etal., FEBS Lett. 2004 May 21;566(1-3):281-6.
9. CDKL5, a protein associated with rett syndrome, regulates neuronal morphogenesis via Rac1 signaling. Chen Q, etal., J Neurosci. 2010 Sep 22;30(38):12777-86. doi: 10.1523/JNEUROSCI.1102-10.2010.
10. Cellular function of RhoGDI-alpha mediates the cycling of Rac1 and the regulation of pancreatic beta cell death. Cho Y, etal., Transplant Proc. 2012 May;44(4):1083-5. doi: 10.1016/j.transproceed.2012.03.021.
11. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
12. Association of RhoGDIalpha with Rac1 GTPase mediates free radical production during myocardial hypertrophy. Custodis F, etal., Cardiovasc Res. 2006 Jul 15;71(2):342-51. Epub 2006 Apr 19.
13. Serine 34 phosphorylation of rho guanine dissociation inhibitor (RhoGDIalpha) links signaling from conventional protein kinase C to RhoGTPase in cell adhesion. Dovas A, etal., J Biol Chem. 2010 Jul 23;285(30):23296-308. doi: 10.1074/jbc.M109.098129. Epub 2010 May 15.
14. Role of Rac1-dependent NADPH oxidase in the growth of pancreatic cancer. Du J, etal., Cancer Gene Ther. 2011 Feb;18(2):135-43. doi: 10.1038/cgt.2010.64. Epub 2010 Oct 29.
15. Clinical value of Tiam1-Rac1 signaling in primary gallbladder carcinoma. Du X, etal., Med Oncol. 2012 Sep;29(3):1873-8. doi: 10.1007/s12032-011-0046-2. Epub 2011 Aug 19.
16. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. Fanger GR, etal., EMBO J. 1997 Aug 15;16(16):4961-72.
17. MicroRNA-142-3p Promotes Cellular Invasion of Colorectal Cancer Cells by Activation of RAC1. Gao X, etal., Technol Cancer Res Treat. 2018 Jan 1;17:1533033818790508. doi: 10.1177/1533033818790508.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. DAMTC regulates cytoskeletal reorganization and cell motility in human lung adenocarcinoma cell line: an integrated proteomics and transcriptomics approach. Goel A, etal., Cell Death Dis. 2012 Oct 11;3(10):e402. doi: 10.1038/cddis.2012.141.
20. RAC1b Overexpression Confers Resistance to Chemotherapy Treatment in Colorectal Cancer. Goka ET, etal., Mol Cancer Ther. 2019 May;18(5):957-968. doi: 10.1158/1535-7163.MCT-18-0955. Epub 2019 Mar 29.
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1 to 10 of 23 rows
PMID:8625410   PMID:8631991   PMID:9312003   PMID:10036235   PMID:10699171   PMID:10934045   PMID:10954424   PMID:12213441   PMID:12446704   PMID:12525493   PMID:12612085   PMID:12699088  
PMID:12719791   PMID:12777392   PMID:12783890   PMID:12853475   PMID:12915445   PMID:14516655   PMID:14570905   PMID:14573547   PMID:14580336   PMID:14657280   PMID:14736704   PMID:15037605  
PMID:15121898   PMID:15210825   PMID:15213258   PMID:15226395   PMID:15249579   PMID:15262848   PMID:15308668   PMID:15308673   PMID:15351707   PMID:15467718   PMID:15494521   PMID:15601624  
PMID:15611338   PMID:15629443   PMID:15634677   PMID:15721239   PMID:15723051   PMID:15728191   PMID:15728722   PMID:15826947   PMID:16092944   PMID:16168664   PMID:16195887   PMID:16283857  
PMID:16291935   PMID:16354758   PMID:16439689   PMID:16515795   PMID:16636067   PMID:16801538   PMID:16954223   PMID:16982892   PMID:17085464   PMID:17088251   PMID:17109063   PMID:17109064  
PMID:17130476   PMID:17183546   PMID:17207463   PMID:17300916   PMID:17350025   PMID:17409253   PMID:17515454   PMID:17515837   PMID:17561310   PMID:17687038   PMID:17702745   PMID:17982273  
PMID:18006851   PMID:18079208   PMID:18156211   PMID:18172037   PMID:18218673   PMID:18316075   PMID:18335519   PMID:18567639   PMID:18599477   PMID:18805958   PMID:18953410   PMID:19007770  
PMID:19027829   PMID:19052208   PMID:19067793   PMID:19085564   PMID:19126672   PMID:19261846   PMID:19289122   PMID:19356729   PMID:19368836   PMID:19403692   PMID:19581409   PMID:19625648  
PMID:19787194   PMID:19812310   PMID:19850129   PMID:19854265   PMID:19890013   PMID:19923407   PMID:19934221   PMID:20004474   PMID:20016102   PMID:20018732   PMID:20069557   PMID:20097736  
PMID:20139976   PMID:20335472   PMID:20339116   PMID:20363326   PMID:20387077   PMID:20458337   PMID:20519585   PMID:20530489   PMID:20578145   PMID:20691665   PMID:20696841   PMID:20808927  
1 to 10 of 23 rows



Rac1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81216,150,411 - 16,170,864 (+)NCBIGRCr8
mRatBN7.21211,037,028 - 11,057,251 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1211,036,698 - 11,057,251 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1211,844,100 - 11,864,510 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,467,387 - 12,487,799 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01211,492,647 - 11,513,133 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,090,316 - 13,111,841 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,090,172 - 13,111,873 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01215,133,521 - 15,153,741 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41211,380,314 - 11,400,531 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11211,419,965 - 11,428,962 (+)NCBI
Celera1212,831,091 - 12,851,324 (+)NCBICelera
Cytogenetic Map12p11NCBI
RAC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3876,374,527 - 6,403,967 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl76,374,527 - 6,403,967 (+)EnsemblGRCh38hg38GRCh38
GRCh3776,414,158 - 6,443,598 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3676,380,651 - 6,410,123 (+)NCBINCBI36Build 36hg18NCBI36
Celera76,291,529 - 6,321,004 (-)NCBICelera
Cytogenetic Map7p22.1NCBI
HuRef76,287,239 - 6,316,490 (+)NCBIHuRef
CHM1_176,413,683 - 6,443,197 (+)NCBICHM1_1
T2T-CHM13v2.076,493,927 - 6,523,370 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v276,460,486 - 6,489,951 (+)NCBI
Rac1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395143,491,236 - 143,513,786 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5143,489,389 - 143,513,791 (-)EnsemblGRCm39 Ensembl
GRCm385143,505,481 - 143,528,031 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5143,503,634 - 143,528,036 (-)EnsemblGRCm38mm10GRCm38
MGSCv375144,266,349 - 144,288,861 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365143,761,100 - 143,783,611 (-)NCBIMGSCv36mm8
Celera5140,552,192 - 140,574,740 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map582.22NCBI
Rac1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546013,270,159 - 13,311,351 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495546013,270,159 - 13,295,562 (-)NCBIChiLan1.0ChiLan1.0
RAC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2611,267,125 - 11,296,710 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1759,591,833 - 59,621,373 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v077,039,379 - 7,068,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.176,559,590 - 6,599,814 (+)NCBIpanpan1.1PanPan1.1panPan2
RAC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1611,726,259 - 11,758,532 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl611,655,494 - 11,757,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha613,358,080 - 13,382,295 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0611,733,309 - 11,759,080 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl611,733,323 - 11,759,075 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1611,609,365 - 11,633,590 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0611,589,106 - 11,613,379 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0611,817,075 - 11,841,312 (+)NCBIUU_Cfam_GSD_1.0
Rac1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344139,822,631 - 139,837,571 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936750107,689 - 122,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936750107,689 - 122,679 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RAC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl34,781,780 - 4,803,543 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.134,781,776 - 4,803,510 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RAC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12815,583,609 - 15,610,753 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2815,583,516 - 15,610,328 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666102459,743 - 488,113 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rac1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474030,911,598 - 30,934,025 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474030,912,841 - 30,933,882 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Rac1
51 total Variants

Predicted Target Of
Summary Value
Count of predictions:175
Count of miRNA genes:126
Interacting mature miRNAs:132
Transcripts:ENSRNOT00000001417
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 35 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
1331739Hrtrt14Heart rate QTL 143.56232heart pumping trait (VT:2000009)heart rate (CMO:0000002)12931821612829686Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)12960327746669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
61331Eau2Experimental allergic uveoretinitis QTL 20.0005uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)12852542328064601Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat

1 to 10 of 35 rows
RH140831  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21211,057,339 - 11,057,559 (+)MAPPERmRatBN7.2
Rnor_6.01213,110,681 - 13,110,900NCBIRnor6.0
Rnor_5.01215,153,830 - 15,154,049UniSTSRnor5.0
RGSC_v3.41211,400,620 - 11,400,839UniSTSRGSC3.4
Celera1212,851,413 - 12,851,632UniSTS
RH 3.4 Map12145.61UniSTS
Cytogenetic Map12p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001417   ⟹   ENSRNOP00000001417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1213,090,367 - 13,111,873 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000087094   ⟹   ENSRNOP00000071616
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,046,647 - 11,057,251 (+)Ensembl
Rnor_6.0 Ensembl1213,097,269 - 13,110,592 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092558   ⟹   ENSRNOP00000075900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,036,698 - 11,057,251 (+)Ensembl
Rnor_6.0 Ensembl1213,090,172 - 13,109,135 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000092628   ⟹   ENSRNOP00000075897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1213,102,019 - 13,102,706 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000113039   ⟹   ENSRNOP00000076799
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,043,004 - 11,057,251 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114561   ⟹   ENSRNOP00000091529
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1211,043,004 - 11,057,251 (+)Ensembl
RefSeq Acc Id: NM_134366   ⟹   NP_599193
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,150,643 - 16,170,864 (+)NCBI
mRatBN7.21211,037,028 - 11,057,251 (+)NCBI
Rnor_6.01213,090,372 - 13,110,592 (+)NCBI
Rnor_5.01215,133,521 - 15,153,741 (+)NCBI
RGSC_v3.41211,380,314 - 11,400,531 (+)RGD
Celera1212,831,091 - 12,851,324 (+)RGD
Sequence:
RefSeq Acc Id: XM_063271554   ⟹   XP_063127624
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81216,150,411 - 16,170,581 (+)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_599193 (Get FASTA)   NCBI Sequence Viewer  
  XP_063127624 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK66567 (Get FASTA)   NCBI Sequence Viewer  
  AAR84574 (Get FASTA)   NCBI Sequence Viewer  
  EDL89664 (Get FASTA)   NCBI Sequence Viewer  
  EDL89665 (Get FASTA)   NCBI Sequence Viewer  
  EDL89666 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075900
GenBank Protein Q6RUV5 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_599193   ⟸   NM_134366
- UniProtKB: Q6RUV5 (UniProtKB/Swiss-Prot),   A0A0G2K0X4 (UniProtKB/TrEMBL),   A6K1K8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075897   ⟸   ENSRNOT00000092628
Ensembl Acc Id: ENSRNOP00000075900   ⟸   ENSRNOT00000092558
Ensembl Acc Id: ENSRNOP00000071616   ⟸   ENSRNOT00000087094
Ensembl Acc Id: ENSRNOP00000001417   ⟸   ENSRNOT00000001417

Name Modeler Protein Id AA Range Protein Structure
AF-Q6RUV5-F1-model_v2 AlphaFold Q6RUV5 1-192 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698441
Promoter ID:EPDNEW_R8962
Type:initiation region
Name:Rac1_1
Description:ras-related C3 botulinum toxin substrate 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,090,171 - 13,090,231EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-20008 BioCyc
Ensembl Genes ENSRNOG00000001068 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000092558 ENTREZGENE
Gene3D-CATH 3.40.50.300 UniProtKB/Swiss-Prot
InterPro P-loop_NTPase UniProtKB/Swiss-Prot
  Small_GTP-bd_dom UniProtKB/Swiss-Prot
  Small_GTPase UniProtKB/Swiss-Prot
  Small_GTPase_Rho UniProtKB/Swiss-Prot
KEGG Report rno:363875 UniProtKB/Swiss-Prot
NCBI Gene Rac1 ENTREZGENE
PANTHER PTHR24072 UniProtKB/Swiss-Prot
Pfam Ras UniProtKB/Swiss-Prot
PharmGKB RAC1 RGD
PhenoGen Rac1 PhenoGen
PRINTS RASTRNSFRMNG UniProtKB/Swiss-Prot
PROSITE RHO UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001068 RatGTEx
  ENSRNOG00000007350 RatGTEx
SMART RAB UniProtKB/Swiss-Prot
  RAS UniProtKB/Swiss-Prot
  RHO UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A0G2K0X4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0U1RS21_RAT UniProtKB/TrEMBL
  A0A8I5Y5L2_RAT UniProtKB/TrEMBL
  A0A8I6ADV8_RAT UniProtKB/TrEMBL
  A0A8I6G820 ENTREZGENE, UniProtKB/TrEMBL
  A6K1K6_RAT UniProtKB/TrEMBL
  A6K1K8 ENTREZGENE, UniProtKB/TrEMBL
  Q6RUV5 ENTREZGENE, UniProtKB/Swiss-Prot
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 Rac1  Rac family small GTPase 1  Rac1  ras-related C3 botulinum toxin substrate 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Rac1  ras-related C3 botulinum toxin substrate 1    ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)  Name updated 1299863 APPROVED
2002-08-07 Rac1  ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)      Symbol and Name status set to provisional 70820 PROVISIONAL

Note Type Note Reference
gene_cellular_localization colocalizes at the plasma membrane of RBL-2H3 cells in actin-rich structures with phospholipase D, ARF6, and PKC alpha following antigen stimulation 727254
gene_expression expressed in hippocampus and cerebellum 1299238
gene_process enhanced the expression of a kappaB and induced the degradation of IkappaBalpha 704329
gene_process essential for leukotriene B4 induced production of reactive oxygen species, chemotaxis, and cellular proliferation 1299245
gene_process may play a role in synaptic plasticity in brain 1299238
gene_process may play a role in cellular motility through regulation by stretch tension 1299247
gene_regulation activated by treatment of cells with lipopolysaccharide (LPS) 1299246