Gstm5 (glutathione S-transferase, mu 5) - Rat Genome Database

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Gene: Gstm5 (glutathione S-transferase, mu 5) Rattus norvegicus
Analyze
Symbol: Gstm5
Name: glutathione S-transferase, mu 5
RGD ID: 61964
Description: Enables glutathione transferase activity and identical protein binding activity. Predicted to be involved in several processes, including cellular detoxification of nitrogen compound; nitrobenzene metabolic process; and response to estrogen. Predicted to be located in cytosol and sperm fibrous sheath. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; cystic fibrosis; larynx cancer; multiple sclerosis; and osteosarcoma. Orthologous to human GSTM3 (glutathione S-transferase mu 3); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH 1-chloro-2,4-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase mu 3; glutathione S-transferase Mu 5; GST class-mu 5; Gstm3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,219,769 - 198,222,732 (+)NCBIGRCr8
GRCr8 Ensembl2198,219,647 - 198,222,731 (+)EnsemblGRCr8 Ensembl
mRatBN7.22195,531,599 - 195,534,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,531,495 - 195,534,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,173,992 - 203,176,787 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,056,113 - 201,058,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,873,066 - 195,875,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,685,338 - 210,688,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,685,197 - 210,688,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,154,305 - 230,157,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,456,122 - 203,458,917 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2188,178,084 - 188,180,884 (+)NCBICelera
RGSC_v3.12203,418,875 - 203,421,671 (+)NCBI
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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1 to 11 of 11 rows
Object Symbol
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Reference
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Original Reference(s)
Gstm5Ratautistic disorder  ISOGSTM3 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106|PMID:30208311
Gstm5Rathereditary spastic paraplegia 63  ISOGSTM3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 63ClinVarPMID:23911318|PMID:28492532
Object Symbol
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Term
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Evidence
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Reference
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Original Reference(s)
Gstm5RatChemical and Drug Induced Liver Injury  ISOGSTM3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:25743375
Gstm5RatChloracne  ISOGSTM3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17101203
Gstm5RatColorectal Neoplasms  ISOGSTM3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17892325
Gstm5RatProstatic Neoplasms  ISOGSTM3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14968442

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Original Reference(s)
Gstm5Rat(1->4)-beta-D-glucan multiple interactionsISOGstm5 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GSTM3 mRNACTDPMID:36331819
Gstm5Rat1,2-dichloroethane decreases expressionISOGstm5 (Mus musculus)6480464ethylene dichloride results in decreased expression of GSTM3 mRNACTDPMID:28189721|PMID:28960355
Gstm5Rat1,2-dimethylhydrazine decreases expressionISOGstm5 (Mus musculus)64804641,2-Dimethylhydrazine results in decreased expression of GSTM3 mRNACTDPMID:22206623
Gstm5Rat1,4-dioxane increases expressionISOGstm5 (Mus musculus)64804641,4-dioxane results in increased expression of GSTM3 mRNACTDPMID:33693819
Gstm5Rat1-chloro-2,4-dinitrobenzene increases metabolic processingISOGSTM3 (Homo sapiens)6480464GSTM3 protein polymorphism results in increased metabolism of DinitrochlorobenzeneCTDPMID:15247628
Gstm5Rat1-chloro-2,4-dinitrobenzene decreases expressionISOGstm5 (Mus musculus)6480464Dinitrochlorobenzene results in decreased expression of GSTM3 mRNACTDPMID:21404309
Gstm5Rat1-chloro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrochlorobenzene results in increased expression of GSTM3 proteinCTDPMID:9794801
Gstm5Rat1-chloro-2,4-dinitrobenzene affects metabolic processingEXP 6480464GSTM3 protein affects the metabolism of DinitrochlorobenzeneCTDPMID:3169012
Gstm5Rat1-chloro-2,4-dinitrobenzene affects metabolic processingISOGSTM3 (Homo sapiens)6480464GSTM3 protein affects the metabolism of DinitrochlorobenzeneCTDPMID:9545290
Gstm5Rat1-chloro-2,4-dinitrobenzene decreases metabolic processingISOGSTM3 (Homo sapiens)6480464GSTM3 protein polymorphism results in decreased metabolism of DinitrochlorobenzeneCTDPMID:15247628
Gstm5Rat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of GSTM3 mRNACTDPMID:17522070
Gstm5Rat1-naphthyl isothiocyanate multiple interactionsISOGstm5 (Mus musculus)6480464[1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of GSTM3 mRNA; [1-Naphthylisothiocyanate co-treated with Uric more ...CTDPMID:33749747
Gstm5Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of GSTM3 mRNACTDPMID:30723492
Gstm5Rat1-naphthyl isothiocyanate increases expressionISOGstm5 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of GSTM3 mRNACTDPMID:30517764|PMID:33749747
Gstm5Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of GSTM3 mRNACTDPMID:15576828|PMID:15834898|PMID:17557909
Gstm5Rat17alpha-ethynylestradiol decreases expressionISOGstm5 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of GSTM3 mRNACTDPMID:17942748
Gstm5Rat17alpha-ethynylestradiol affects expressionISOGstm5 (Mus musculus)6480464Ethinyl Estradiol affects the expression of GSTM3 mRNACTDPMID:17555576
Gstm5Rat17alpha-ethynylestradiol multiple interactionsISOGstm5 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of GSTM3 mRNACTDPMID:17942748
Gstm5Rat17beta-estradiol increases expressionISOGSTM3 (Homo sapiens)6480464Estradiol results in increased expression of GSTM3 mRNACTDPMID:11331657
Gstm5Rat17beta-estradiol decreases expressionISOGstm5 (Mus musculus)6480464Estradiol results in decreased expression of GSTM3 mRNACTDPMID:14664709|PMID:39298647

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Biological Process
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Original Reference(s)
Gstm5Ratbiological_process  ND 159840711/2008: no relevant rat dataRGD 
Gstm5Ratcellular detoxification of nitrogen compound involved_inISOGSTM3 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm5Ratcellular detoxification of nitrogen compound involved_inIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratglutathione metabolic process involved_inISSUniProtKB:P464391600115GO_REF:0000024UniProtGO_REF:0000024
Gstm5Ratglutathione metabolic process involved_inIBAFB:FBgn0010226|MGI:95864|MGI:95865|PANTHER:PTN000170884|RGD:2755|RGD:2756|UniProtKB:O15217|UniProtKB:P08263|UniProtKB:P09211|UniProtKB:P09488|UniProtKB:P21266|UniProtKB:P28161|UniProtKB:P46439|UniProtKB:Q03013|UniProtKB:Q8ILQ7|WB:WBGene00001752|WB:WBGene000017581600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstm5Ratglutathione metabolic process involved_inIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratglutathione metabolic process involved_inISOGSTM3 (Homo sapiens)1624291 PMID:10587441, PMID:8373352RGDPMID:10587441|PMID:8373352
Gstm5Ratnitrobenzene metabolic process involved_inISOGSTM3 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm5Ratnitrobenzene metabolic process involved_inIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratresponse to estrogen involved_inISOGSTM3 (Homo sapiens)1624291 PMID:10037815RGDPMID:10037815
Gstm5Ratresponse to estrogen involved_inIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratxenobiotic catabolic process involved_inISOGSTM3 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm5Ratxenobiotic catabolic process involved_inIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component

  
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Original Reference(s)
Gstm5Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gstm5Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gstm5Ratcytoplasm located_inIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratcytoplasm located_inISOGSTM3 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm5Ratcytosol located_inISOGstm5 (Mus musculus)1624291 PMID:15100242RGDPMID:15100242
Gstm5Ratcytosol located_inIEAUniProtKB:P48774|ensembl:ENSMUSP000000041341600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratsperm fibrous sheath located_inISOGstm5 (Mus musculus)1624291 PMID:16687649, PMID:19889946RGDPMID:16687649|PMID:19889946
Gstm5Ratsperm fibrous sheath located_inIEAUniProtKB:P48774|ensembl:ENSMUSP000000041341600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function
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Original Reference(s)
Gstm5Ratenzyme binding enablesISOGSTM3 (Homo sapiens)1624291UniProtKB:P21266 PMID:8373352RGDPMID:8373352
Gstm5Ratenzyme binding enablesIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratglutathione binding enablesISOGSTM3 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm5Ratglutathione binding enablesIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratglutathione transferase activity enablesISOGSTM3 (Homo sapiens)1624291 PMID:10587441, PMID:8373352, PMID:9545290RGDPMID:10587441|PMID:8373352|PMID:9545290
Gstm5Ratglutathione transferase activity enablesISOGstm5 (Mus musculus)1624291 PMID:9545290RGDPMID:9545290
Gstm5Ratglutathione transferase activity enablesIBAFB:FBgn0010226|MGI:1095417|MGI:1309466|MGI:95856|MGI:95861|MGI:95862|MGI:95863|MGI:95864|MGI:95865|PANTHER:PTN000170884|RGD:1593189|RGD:2753|RGD:2754|RGD:2755|RGD:2756|RGD:61964|UniProtKB:C8V321|UniProtKB:O15217|UniProtKB:P08263|UniProtKB:P09211|UniProtKB:P09488|UniProtKB:P21266|UniProtKB:P28161|UniProtKB:P46439|UniProtKB:Q03013|UniProtKB:Q8ILQ7|WB:WBGene00001749|WB:WBGene00001752|WB:WBGene00001758|ZFIN:ZDB-GENE-020806-4|ZFIN:ZDB-GENE-030911-2|ZFIN:ZDB-GENE-050309-24|ZFIN:ZDB-GENE-050601-1|dictyBase:DDB_G02726321600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstm5Ratglutathione transferase activity enablesIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratglutathione transferase activity enablesIEAUniProtKB:P48774|ensembl:ENSMUSP000000041341600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratglutathione transferase activity enablesIEAARBA:ARBA000263631600115GO_REF:0000117UniProtGO_REF:0000117
Gstm5Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gstm5Ratglutathione transferase activity enablesIEAInterPro:IPR0030811600115GO_REF:0000002InterProGO_REF:0000002
Gstm5Ratglutathione transferase activity enablesIDA 61624PMID:9545290MGI 
Gstm5Ratidentical protein binding enablesIDA 61624PMID:9545290MGI 
Gstm5Ratidentical protein binding enablesIEAUniProtKB:P48774|ensembl:ENSMUSP000000041341600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratidentical protein binding enablesIEAUniProtKB:P21266|ensembl:ENSP000003543571600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm5Ratidentical protein binding enablesISOGstm5 (Mus musculus)1624291PR:P48774 PMID:9545290RGDPMID:9545290
Gstm5Ratidentical protein binding enablesISOGSTM3 (Homo sapiens)1624291UniProtKB:P21266 PMID:16189514, PMID:19060904, PMID:21516116, PMID:31515488, PMID:32296183RGDPMID:16189514|PMID:19060904|PMID:21516116|PMID:31515488|PMID:32296183
Gstm5Ratidentical protein binding enablesIEAARBA:ARBA000279301600115GO_REF:0000117UniProtGO_REF:0000117
Gstm5Ratprotein binding enablesISOGSTM3 (Homo sapiens)1624291UniProtKB:P21754|UniProtKB:P46439|UniProtKB:Q03013|UniProtKB:Q12836|UniProtKB:Q5SYC1 PMID:23355646, PMID:25416956, PMID:28514442, PMID:31515488, PMID:32296183, PMID:33961781RGDPMID:23355646|PMID:25416956|PMID:28514442|PMID:31515488|PMID:32296183|PMID:33961781
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RGD Manual Annotations


  
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Original Reference(s)
Gstm5Ratglutathione conjugation pathway  ISS 1358120 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Gstm5Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gstm5Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gstm5Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. DNA methylation is associated with altered gene expression in AMD. Hunter A, etal., Invest Ophthalmol Vis Sci. 2012 Apr 24;53(4):2089-105. doi: 10.1167/iovs.11-8449.
3. A GSTM3 polymorphism associated with an etiopathogenetic mechanism in Alzheimer disease. Maes OC, etal., Neurobiol Aging. 2010 Jan;31(1):34-45. Epub 2008 Apr 17.
4. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Multiple glutathione S-transferase isoforms are present on male germ cell plasma membrane. Rao AV and Shaha C, FEBS Lett. 2001 Oct 26;507(2):174-80.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Rationale for reclassification of a distinctive subdivision of mammalian class Mu glutathione S-transferases that are primarily expressed in testis. Rowe JD, etal., J Biol Chem 1998 Apr 17;273(16):9593-601.
11. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
12. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 12 of 12 rows
PMID:6822548   PMID:8373352   PMID:8512323   PMID:10037815   PMID:10067818   PMID:10587441   PMID:10680782   PMID:11470996   PMID:15115915   PMID:15621212   PMID:16189514   PMID:16598069  
PMID:16687649   PMID:17550934   PMID:19060904   PMID:19723343   PMID:19889946   PMID:20577141   PMID:21516116   PMID:21630459   PMID:23012479   PMID:23376485   PMID:23533145   PMID:25931508  
PMID:31515488  



Gstm5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,219,769 - 198,222,732 (+)NCBIGRCr8
GRCr8 Ensembl2198,219,647 - 198,222,731 (+)EnsemblGRCr8 Ensembl
mRatBN7.22195,531,599 - 195,534,562 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,531,495 - 195,534,553 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,173,992 - 203,176,787 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,056,113 - 201,058,908 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,873,066 - 195,875,861 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,685,338 - 210,688,133 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,685,197 - 210,688,272 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,154,305 - 230,157,100 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,456,122 - 203,458,917 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2188,178,084 - 188,180,884 (+)NCBICelera
RGSC_v3.12203,418,875 - 203,421,671 (+)NCBI
Cytogenetic Map2q34NCBI
GSTM3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,733,937 - 109,741,038 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,733,932 - 109,741,038 (-)EnsemblGRCh38hg38GRCh38
GRCh371110,276,559 - 110,283,660 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,078,077 - 110,084,563 (-)NCBINCBI36Build 36hg18NCBI36
Build 341109,988,595 - 109,995,082NCBI
Celera1108,523,169 - 108,530,274 (-)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,146,319 - 108,153,420 (-)NCBIHuRef
CHM1_11110,391,373 - 110,398,478 (-)NCBICHM1_1
T2T-CHM13v2.01109,744,083 - 109,751,183 (-)NCBIT2T-CHM13v2.0
Gstm5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,803,240 - 107,806,002 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,803,137 - 107,806,002 (+)EnsemblGRCm39 Ensembl
GRCm383107,895,854 - 107,898,685 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,895,821 - 107,898,686 (+)EnsemblGRCm38mm10GRCm38
MGSCv373107,698,772 - 107,701,603 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,023,910 - 108,026,741 (+)NCBIMGSCv36mm8
Celera3110,228,602 - 110,231,433 (+)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
Gstm3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543513,253,947 - 13,256,965 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543513,253,947 - 13,256,965 (-)NCBIChiLan1.0ChiLan1.0
GSTM3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,304,765 - 117,308,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,452,825 - 116,456,924 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01112,380,890 - 112,384,988 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11127,956,485 - 127,960,583 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,957,008 - 127,960,578 (+)Ensemblpanpan1.1panPan2
GSTM3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1642,187,869 - 42,191,274 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl642,187,967 - 42,191,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha644,963,499 - 44,966,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0642,519,524 - 42,522,915 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl642,519,762 - 42,523,399 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1642,252,336 - 42,255,734 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0642,210,095 - 42,213,500 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0642,645,471 - 42,648,416 (+)NCBIUU_Cfam_GSD_1.0
Gstm3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505818,877,269 - 18,880,232 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367041,233,780 - 1,237,329 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367041,233,909 - 1,236,864 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GSTM3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4110,330,028 - 110,332,962 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14110,330,027 - 110,332,957 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24120,827,568 - 120,830,517 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTM3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,797,794 - 23,802,910 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2023,799,177 - 23,802,921 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603834,656,028 - 34,661,589 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gstm3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247725,495,452 - 5,498,652 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247725,495,452 - 5,498,714 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Gstm5
10 total Variants

Predicted Target Of
Summary Value
Count of predictions:183
Count of miRNA genes:97
Interacting mature miRNAs:110
Transcripts:ENSRNOT00000072342, ENSRNOT00000073649
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 65 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat

1 to 10 of 65 rows
RH129596  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,534,369 - 195,534,551 (+)MAPPERmRatBN7.2
Rnor_6.02210,688,081 - 210,688,262NCBIRnor6.0
Rnor_5.02230,157,048 - 230,157,229UniSTSRnor5.0
Rnor_5.02228,699,710 - 228,699,891UniSTSRnor5.0
RGSC_v3.42203,458,865 - 203,459,046UniSTSRGSC3.4
Celera2188,180,832 - 188,181,013UniSTS
RH 3.4 Map21390.7UniSTS
Cytogenetic Map2q34UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 12 60 56 48 24 12 24 12 99 48 36 15 43 24



Ensembl Acc Id: ENSRNOT00000072342   ⟹   ENSRNOP00000065389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,531,495 - 195,534,553 (+)Ensembl
Rnor_6.0 Ensembl2210,685,197 - 210,688,272 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090430   ⟹   ENSRNOP00000070934
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,531,916 - 195,534,553 (+)Ensembl
RefSeq Acc Id: NM_172038   ⟹   NP_742035
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,219,769 - 198,222,732 (+)NCBI
mRatBN7.22195,531,599 - 195,534,562 (+)NCBI
Rnor_6.02210,685,338 - 210,688,133 (+)NCBI
Rnor_5.02230,154,305 - 230,157,100 (+)NCBI
RGSC_v3.42203,456,122 - 203,458,917 (+)RGD
Celera2188,178,084 - 188,180,884 (+)RGD
Sequence:
RefSeq Acc Id: XM_039103048   ⟹   XP_038958976
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,220,145 - 198,222,732 (+)NCBI
mRatBN7.22195,531,970 - 195,534,562 (+)NCBI
Protein RefSeqs NP_742035 (Get FASTA)   NCBI Sequence Viewer  
  XP_038958976 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD00603 (Get FASTA)   NCBI Sequence Viewer  
  EDL81893 (Get FASTA)   NCBI Sequence Viewer  
  EDL81894 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000065389
  ENSRNOP00000065389.1
GenBank Protein Q9Z1B2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_742035   ⟸   NM_172038
- UniProtKB: Q9Z1B2 (UniProtKB/Swiss-Prot),   A6HUV7 (UniProtKB/TrEMBL),   A0A8L2R3A5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000065389   ⟸   ENSRNOT00000072342
RefSeq Acc Id: XP_038958976   ⟸   XM_039103048
- Peptide Label: isoform X1
- UniProtKB: A6HUV8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000070934   ⟸   ENSRNOT00000090430
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q9Z1B2-F1-model_v2 AlphaFold Q9Z1B2 1-225 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691665
Promoter ID:EPDNEW_R2189
Type:initiation region
Name:Gstm3_1
Description:glutathione S-transferase mu 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,685,310 - 210,685,370EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51655 BioCyc
Ensembl Genes ENSRNOG00000049743 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000072342 ENTREZGENE
  ENSRNOT00000072342.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_mu UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:64352 UniProtKB/Swiss-Prot
NCBI Gene 64352 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE MU 3 UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PhenoGen Gstm5 PhenoGen
PRINTS GSTRNSFRASEM UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049743 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
TIGR TC230112
UniProt A0A8L2R3A5 ENTREZGENE, UniProtKB/TrEMBL
  A6HUV7 ENTREZGENE, UniProtKB/TrEMBL
  A6HUV8 ENTREZGENE, UniProtKB/TrEMBL
  GSTM5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Gstm5  glutathione S-transferase, mu 5      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression expressed mainly in testis 61624