Txnrd1 (thioredoxin reductase 1) - Rat Genome Database

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Gene: Txnrd1 (thioredoxin reductase 1) Rattus norvegicus
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Symbol: Txnrd1
Name: thioredoxin reductase 1
RGD ID: 61959
Description: Enables several functions, including NADPH peroxidase activity; mercury ion binding activity; and selenate reductase activity. Involved in several processes, including NADPH oxidation; cellular response to copper ion; and cellular response to hyperoxia. Located in neuronal cell body. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human TXNRD1 (thioredoxin reductase 1); PARTICIPATES IN pyrimidine metabolic pathway; selenoamino acid metabolic pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC93353; NADPH-dependent thioredoxin reductase; peroxidase TXNRD1; selenoprotein oxidoreductase; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase TR1; Tr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,717,620 - 22,802,553 (-)NCBIGRCr8
mRatBN7.2720,830,042 - 20,914,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,830,045 - 20,907,863 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx722,794,109 - 22,878,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,956,878 - 25,041,383 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,733,893 - 24,818,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,946,124 - 26,984,400 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,946,125 - 26,984,400 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,065,819 - 27,104,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,055,544 - 23,093,815 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,075,818 - 23,112,858 (-)NCBI
Celera718,009,974 - 18,048,177 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP,ISO)
(+)-taxifolin  (EXP,ISO)
(+/-)-Aegeline  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-quinic acid  (ISO)
(1->4)-beta-D-glucan  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-lipoic acid  (EXP,ISO)
(RS)-coclaurine  (ISO)
(RS)-norcoclaurine  (ISO)
(S)-coclaurine  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-tribromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-butoxyethanol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxynon-2-enal  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7beta-aminocephalosporanic acid  (ISO)
7H-xanthine  (EXP)
8-hydroxy-2'-deoxyguanosine  (ISO)
9H-xanthine  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
actinomycin D  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP)
allyl isothiocyanate  (ISO)
alpha-D-galactose  (ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
andrographolide  (ISO)
antimonite  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
aristolochic acid A  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
Augmentin  (ISO)
auranofin  (EXP,ISO)
Aurothioglucose  (ISO)
avobenzone  (ISO)
azathioprine  (ISO)
Bandrowski's base  (ISO)
Bardoxolone methyl  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzoic acid  (ISO)
benzyl isothiocyanate  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bosentan  (ISO)
Brodifacoum  (EXP)
bromobenzene  (EXP)
busulfan  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbon nanotube  (ISO)
carmustine  (EXP)
celastrol  (ISO)
cerium trichloride  (ISO)
CHIR 99021  (ISO)
chlorambucil  (EXP)
chlorite  (ISO)
chloroacetaldehyde  (ISO)
chlorobenzene  (ISO)
chloroform  (EXP)
chloropicrin  (ISO)
chloroprene  (EXP,ISO)
chlorpromazine  (ISO)
chlorpyrifos  (ISO)
Cholestane-3,5,6-triol  (EXP)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
clavulanic acid  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
coniferyl aldehyde  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
cortisol  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
Diallyl sulfide  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
dibenziodolium  (ISO)
diclofenac  (EXP,ISO)
diethyl maleate  (ISO)
dimercaprol  (EXP)
dimethylarsinic acid  (ISO)
dinitrogen  (EXP)
dioxygen  (EXP,ISO)
Diphenyl disulfide  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (EXP,ISO)
disulfiram  (ISO)
dithionitrobenzoic acid  (EXP,ISO)
dorsomorphin  (ISO)
ebselen  (ISO)
elemental selenium  (EXP,ISO)
elesclomol  (ISO)
emodin  (EXP,ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epichlorohydrin  (ISO)
Erucin  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
ethylenediaminetetraacetic acid  (ISO)
eugenol  (ISO)
felbamate  (EXP)
fenamidone  (ISO)
fenofibrate  (ISO)
fenpyroximate  (ISO)
flucloxacillin  (ISO)
fluoranthene  (ISO)
fluprostenol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formic acid  (EXP)
formononetin  (ISO)
fulvestrant  (ISO)
furan  (EXP,ISO)
gabapentin  (EXP)
galactose  (ISO)
gamma-linolenic acid  (ISO)
gedunin  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glutathione  (EXP)
glyoxal  (ISO)
gold atom  (EXP,ISO)
gold(0)  (EXP,ISO)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hexamethylene diisocyanate  (ISO)
hexane  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hypochlorous acid  (ISO)
iberin  (ISO)
ifosfamide  (ISO)
indoles  (EXP)
irinotecan  (EXP)
iron atom  (ISO)
iron dextran  (ISO)
iron(0)  (ISO)
iron(III) citrate  (ISO)
isoeugenol  (ISO)
isoflavones  (ISO)
isoniazide  (ISO)
ivermectin  (ISO)
juglone  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
lipoamide  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
lutein  (ISO)
luteolin  (ISO)
LY294002  (EXP)
maneb  (ISO)
manganese(II) chloride  (EXP)
mechlorethamine  (EXP,ISO)
melphalan  (EXP)
menadione  (ISO)
mercury atom  (ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methylene blue  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
miconazole  (EXP)
microcystin-LR  (ISO)
mitomycin C  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
morin  (EXP)
motexafin gadolinium  (ISO)
myricetin  (EXP)
N(6)-dimethylallyladenine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (EXP)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methylformamide  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
NADP zwitterion  (EXP,ISO)
NADP(+)  (EXP,ISO)
naphthalene  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
nimesulide  (EXP)
nitrogen dioxide  (ISO)
nitrososulfamethoxazole  (ISO)
Nonidet P-40  (ISO)
ochratoxin A  (EXP)
oltipraz  (ISO)
organoselenium compound  (ISO)
oxaliplatin  (EXP)
oxidopamine  (ISO)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
palladium  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pelargonidin  (EXP)
pentachlorophenol  (ISO)
pentetic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (EXP,ISO)
phenanthridone  (ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP)
phosgene  (ISO)
phosphoramide mustard  (EXP)
picoxystrobin  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
plumbagin  (ISO)
potassium iodide  (EXP)
potassium tellurite  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin B1  (ISO)
propan-2-ol  (ISO)
Pyridostigmine bromide  (EXP)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (ISO)
rimonabant  (EXP)
rotenone  (ISO)
ruxolitinib  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenic acid  (ISO)
selenium atom  (EXP,ISO)
selenocystine  (ISO)
selenomethionine  (ISO)
selenous acid  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium aurothiomalate  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (ISO)
sorafenib  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulfur dioxide  (ISO)
sulindac sulfide  (ISO)
superoxide  (EXP)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetrathiomolybdate(2-)  (ISO)
thallium  (EXP)
thapsigargin  (EXP)
thifluzamide  (ISO)
thioacetamide  (EXP,ISO)
thiram  (ISO)
trans-isoeugenol  (ISO)
triadimefon  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
Triptolide  (EXP,ISO)
Tungsten carbide  (ISO)
undecane  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
wortmannin  (ISO)
XAV939  (ISO)
yohimbine  (ISO)
zinc acetate  (ISO)
zinc atom  (ISO)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IBA,IEA,ISO)
fibrillar center  (IEA,ISO)
mitochondrion  (IBA,IEA)
neuronal cell body  (IDA)
nucleoplasm  (IEA,ISO)
nucleus  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine. Anestal K and Arner ES, J Biol Chem. 2003 May 2;278(18):15966-72. Epub 2003 Feb 6.
2. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
3. Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling. Aranibar N, etal., Magn Reson Chem. 2009 Dec;47 Suppl 1:S12-9.
4. High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes. Arner ES, etal., J Mol Biol 1999 Oct 8;292(5):1003-16.
5. Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. Carvalho CM, etal., FASEB J. 2011 Jan;25(1):370-81. Epub 2010 Sep 1.
6. Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1. Cheng Q, etal., J Biol Chem. 2009 Feb 6;284(6):3998-4008. Epub 2008 Dec 3.
7. Functional expression of rat thioredoxin reductase: selenocysteine insertion sequence element is essential for the active enzyme. Fujiwara N, etal., Biochem J 1999 Jun 1;340 ( Pt 2):439-44.
8. Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins. Furman C, etal., Free Radic Biol Med. 2004 Jul 1;37(1):71-85.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Simultaneous expression of glutathione, thioredoxin-1, and their reductases in nerve transected hypoglossal motor neurons of rat. Hama I, etal., Brain Res. 2010 Jan 8;1306:1-7. Epub 2009 Oct 13.
11. Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase. Hashemy SI, etal., J Biol Chem. 2006 Apr 21;281(16):10691-7. Epub 2006 Feb 14.
12. Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells. Jan YH, etal., Chem Res Toxicol. 2010 Jun 21;23(6):1045-53.
13. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function. Jeong W, etal., J Biol Chem. 2004 Jan 30;279(5):3142-50. Epub 2003 Nov 7.
14. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Jia J, etal., Thromb Res. 2009 Mar;123(5):727-30. Epub 2009 Jan 6.
15. Antioxidant defenses in the rat placenta in late gestation: increased labyrinthine expression of superoxide dismutases, glutathione peroxidase 3, and uncoupling protein 2. Jones ML, etal., Biol Reprod. 2010 Aug 1;83(2):254-60. Epub 2010 Apr 14.
16. Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver. Lee SR, etal., J Biol Chem 1999 Feb 19;274(8):4722-34.
17. Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system. Li X, etal., Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H416-24. Epub 2008 May 30.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset. Mitchell J, etal., Free Radic Biol Med. 2009 Jan 15;46(2):202-11. Epub 2008 Oct 22.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Hyperbaric oxygen preconditioning ameliorates anxiety-like behavior and cognitive impairments via upregulation of thioredoxin reductases in stressed rats. Peng Y, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):1018-25. Epub 2010 May 19.
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. Highly active dimeric and low-activity tetrameric forms of selenium-containing rat thioredoxin reductase 1. Rengby O, etal., Free Radic Biol Med. 2009 Apr 1;46(7):893-904. Epub 2008 Dec 31.
24. GOA pipeline RGD automated data pipeline
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Effects of hyperoxia on cytoplasmic thioredoxin system in alveolar type epithelial cells of premature rats. Shan R, etal., J Huazhong Univ Sci Technolog Med Sci. 2011 Apr;31(2):258-63. Epub 2011 Apr 20.
27. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
28. Post-transcriptional defects of antioxidant selenoenzymes cause oxidative stress under methylmercury exposure. Usuki F, etal., J Biol Chem. 2011 Feb 25;286(8):6641-9. Epub 2010 Nov 24.
29. Effects of dietary selenium on post-ischemic expression of antioxidant mRNA. Venardos K, etal., Mol Cell Biochem. 2005 Feb;270(1-2):131-8.
30. Expression changes of dopaminergic system-related genes in PC12 cells induced by manganese, silver, or copper nanoparticles. Wang J, etal., Neurotoxicology. 2009 Nov;30(6):926-33. Epub 2009 Sep 23.
31. Neuroprotective effect of Buyang Huanwu Decoction on spinal ischemia/reperfusion injury in rats. Wang L and Jiang DM, J Ethnopharmacol. 2009 Jul 15;124(2):219-23. Epub 2009 May 3.
32. The mammalian cytosolic selenoenzyme thioredoxin reductase reduces ubiquinone. A novel mechanism for defense against oxidative stress. Xia L, etal., J Biol Chem 2003 Jan 24;278(4):2141-6.
33. Hepatic transcriptome and proteome responses against diethyl maleate-induced glutathione depletion in the rat. Yamauchi S, etal., Arch Toxicol. 2010 Dec 14.
34. Vitamin E ameliorates iodine-induced cytotoxicity in thyroid. Yu J, etal., J Endocrinol. 2011 Jun;209(3):299-306. Epub 2011 Mar 15.
35. [The change of thioredoxin system in myocardial tissue of type 2 diabetic rats undergoing myocardial injury]. Zhao XQ, etal., Sheng Li Xue Bao. 2010 Jun 25;62(3):261-8.
36. Essential role of selenium in the catalytic activities of mammalian thioredoxin reductase revealed by characterization of recombinant enzymes with selenocysteine mutations. Zhong L and Holmgren A, J Biol Chem 2000 Jun 16;275(24):18121-8.
37. Rat and calf thioredoxin reductase are homologous to glutathione reductase with a carboxyl-terminal elongation containing a conserved catalytically active penultimate selenocysteine residue. Zhong L, etal., J Biol Chem 1998 Apr 10;273(15):8581-91.
Additional References at PubMed
PMID:8889548   PMID:10721726   PMID:10769168   PMID:11259642   PMID:11481439   PMID:12477932   PMID:15713651   PMID:15879598   PMID:15901730   PMID:16750198   PMID:17023680   PMID:17291446  
PMID:17394422   PMID:17697936   PMID:18382651   PMID:18570454   PMID:18614015   PMID:19351701   PMID:20126492   PMID:20524817   PMID:20536427   PMID:21903721   PMID:22177986   PMID:22377061  
PMID:23106098   PMID:23629660   PMID:23802942   PMID:24853413   PMID:24984066   PMID:25055978   PMID:25611390   PMID:26252619   PMID:28551108   PMID:28684416   PMID:32867364   PMID:33649852  


Genomics

Comparative Map Data
Txnrd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,717,620 - 22,802,553 (-)NCBIGRCr8
mRatBN7.2720,830,042 - 20,914,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,830,045 - 20,907,863 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx722,794,109 - 22,878,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,956,878 - 25,041,383 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,733,893 - 24,818,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,946,124 - 26,984,400 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,946,125 - 26,984,400 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,065,819 - 27,104,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,055,544 - 23,093,815 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,075,818 - 23,112,858 (-)NCBI
Celera718,009,974 - 18,048,177 (-)NCBICelera
Cytogenetic Map7q13NCBI
TXNRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812104,215,779 - 104,350,307 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12104,215,779 - 104,350,307 (+)EnsemblGRCh38hg38GRCh38
GRCh3712104,609,557 - 104,744,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612103,133,689 - 103,268,192 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412103,183,193 - 103,246,528NCBI
Celera12104,273,262 - 104,408,523 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12101,669,268 - 101,804,294 (+)NCBIHuRef
CHM1_112104,575,396 - 104,709,877 (+)NCBICHM1_1
T2T-CHM13v2.012104,177,472 - 104,311,962 (+)NCBIT2T-CHM13v2.0
Txnrd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391082,669,785 - 82,733,558 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1082,669,785 - 82,733,546 (+)EnsemblGRCm39 Ensembl
GRCm381082,833,951 - 82,897,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1082,833,951 - 82,897,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv371082,296,696 - 82,360,469 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361082,288,978 - 82,327,511 (+)NCBIMGSCv36mm8
Celera1084,818,861 - 84,882,466 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1040.66NCBI
Txnrd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540538,903,918 - 38,927,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540538,863,762 - 38,928,615 (+)NCBIChiLan1.0ChiLan1.0
TXNRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210112,278,071 - 112,412,731 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112112,274,278 - 112,409,127 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012101,862,703 - 101,925,104 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112105,258,828 - 105,321,112 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12105,187,128 - 105,321,112 (+)Ensemblpanpan1.1panPan2
TXNRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,904,065 - 34,021,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,886,343 - 34,021,696 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,824,269 - 33,941,521 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01034,747,423 - 34,864,919 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1034,747,416 - 34,864,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11034,482,294 - 34,599,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01034,765,845 - 34,883,396 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01034,960,435 - 35,077,894 (-)NCBIUU_Cfam_GSD_1.0
Txnrd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494517,175,082 - 17,233,863 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649210,187,206 - 10,225,989 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649210,185,096 - 10,244,466 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl580,172,260 - 80,236,219 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1580,170,334 - 80,213,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2583,657,828 - 83,701,655 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q2.3NCBI
TXNRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11199,375,740 - 99,559,929 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1199,490,597 - 99,560,267 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037145,442,330 - 145,506,477 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnrd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247504,443,915 - 4,510,380 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247504,444,318 - 4,536,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Txnrd1
1270 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:156
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000013613
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)71816950526029351Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat

Markers in Region
D7Wox51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,857,409 - 20,857,568 (+)MAPPERmRatBN7.2
Rnor_6.0726,973,491 - 26,973,649NCBIRnor6.0
Rnor_5.0727,093,186 - 27,093,344UniSTSRnor5.0
RGSC_v3.4723,082,906 - 23,083,064UniSTSRGSC3.4
Celera718,037,270 - 18,037,428UniSTS
Cytogenetic Map7q13UniSTS
AW527618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,860,129 - 20,860,375 (+)MAPPERmRatBN7.2
Rnor_6.0726,976,211 - 26,976,456NCBIRnor6.0
Rnor_5.0727,095,906 - 27,096,151UniSTSRnor5.0
RGSC_v3.4723,085,626 - 23,085,871UniSTSRGSC3.4
Celera718,039,990 - 18,040,235UniSTS
RH 3.4 Map7117.8UniSTS
Cytogenetic Map7q13UniSTS
RH137037  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,830,099 - 20,830,319 (+)MAPPERmRatBN7.2
Rnor_6.0726,946,182 - 26,946,401NCBIRnor6.0
Rnor_5.0727,065,877 - 27,066,096UniSTSRnor5.0
RGSC_v3.4723,055,602 - 23,055,821UniSTSRGSC3.4
Celera718,010,032 - 18,010,251UniSTS
RH 3.4 Map7118.3UniSTS
Cytogenetic Map7q13UniSTS
RH138724  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,839,177 - 20,839,351 (+)MAPPERmRatBN7.2
Rnor_6.0726,955,263 - 26,955,436NCBIRnor6.0
Rnor_5.0727,074,958 - 27,075,131UniSTSRnor5.0
RGSC_v3.4723,064,678 - 23,064,851UniSTSRGSC3.4
Celera718,019,128 - 18,019,301UniSTS
RH 3.4 Map7117.25UniSTS
Cytogenetic Map7q13UniSTS
AW527618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,860,268 - 20,860,376 (+)MAPPERmRatBN7.2
Rnor_6.0726,976,350 - 26,976,457NCBIRnor6.0
Rnor_5.0727,096,045 - 27,096,152UniSTSRnor5.0
RGSC_v3.4723,085,765 - 23,085,872UniSTSRGSC3.4
Celera718,040,129 - 18,040,236UniSTS
RH 3.4 Map7117.8UniSTS
Cytogenetic Map7q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001351981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001351983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001351984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA955679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF108213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF189711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF220760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF220761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF415095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB579100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ090798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013613   ⟹   ENSRNOP00000013612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl720,830,045 - 20,907,863 (-)Ensembl
Rnor_6.0 Ensembl726,946,125 - 26,984,400 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089545   ⟹   ENSRNOP00000069166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl726,946,125 - 26,983,172 (-)Ensembl
RefSeq Acc Id: NM_001351981   ⟹   NP_001338910
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,717,620 - 22,755,904 (-)NCBI
mRatBN7.2720,830,042 - 20,868,332 (-)NCBI
RefSeq Acc Id: NM_001351983   ⟹   NP_001338912
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,717,620 - 22,764,851 (-)NCBI
mRatBN7.2720,830,042 - 20,877,280 (-)NCBI
RefSeq Acc Id: NM_001351984   ⟹   NP_001338913
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,717,620 - 22,802,553 (-)NCBI
mRatBN7.2720,830,042 - 20,914,990 (-)NCBI
RefSeq Acc Id: NM_031614   ⟹   NP_113802
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,717,620 - 22,755,904 (-)NCBI
mRatBN7.2720,830,042 - 20,868,332 (-)NCBI
Rnor_6.0726,946,124 - 26,984,400 (-)NCBI
Rnor_5.0727,065,819 - 27,104,095 (-)NCBI
RGSC_v3.4723,055,544 - 23,093,815 (-)RGD
Celera718,009,974 - 18,048,177 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_113802   ⟸   NM_031614
- Peptide Label: isoform 1
- UniProtKB: Q9R1I3 (UniProtKB/Swiss-Prot),   Q9JKZ4 (UniProtKB/Swiss-Prot),   Q9JKZ3 (UniProtKB/Swiss-Prot),   Q5U344 (UniProtKB/Swiss-Prot),   O89049 (UniProtKB/Swiss-Prot),   R9PXU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069166   ⟸   ENSRNOT00000089545
RefSeq Acc Id: ENSRNOP00000013612   ⟸   ENSRNOT00000013613
RefSeq Acc Id: NP_001338913   ⟸   NM_001351984
- Peptide Label: isoform 2
- UniProtKB: Q9R1I3 (UniProtKB/Swiss-Prot),   Q9JKZ4 (UniProtKB/Swiss-Prot),   Q9JKZ3 (UniProtKB/Swiss-Prot),   Q5U344 (UniProtKB/Swiss-Prot),   O89049 (UniProtKB/Swiss-Prot),   R9PXU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001338912   ⟸   NM_001351983
- Peptide Label: isoform 1
- UniProtKB: Q9R1I3 (UniProtKB/Swiss-Prot),   Q9JKZ4 (UniProtKB/Swiss-Prot),   Q9JKZ3 (UniProtKB/Swiss-Prot),   Q5U344 (UniProtKB/Swiss-Prot),   O89049 (UniProtKB/Swiss-Prot),   R9PXU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001338910   ⟸   NM_001351981
- Peptide Label: isoform 1
- UniProtKB: Q9R1I3 (UniProtKB/Swiss-Prot),   Q9JKZ4 (UniProtKB/Swiss-Prot),   Q9JKZ3 (UniProtKB/Swiss-Prot),   Q5U344 (UniProtKB/Swiss-Prot),   O89049 (UniProtKB/Swiss-Prot),   R9PXU4 (UniProtKB/TrEMBL)
Protein Domains
FAD/NAD(P)-binding   Pyridine nucleotide-disulphide oxidoreductase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695110
Promoter ID:EPDNEW_R5635
Type:multiple initiation site
Name:Txnrd1_1
Description:thioredoxin reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0726,984,402 - 26,984,462EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:61959 AgrOrtholog
BioCyc Gene G2FUF-34570 BioCyc
BioCyc Pathway THIOREDOX-PWY [thioredoxin pathway] BioCyc
BioCyc Pathway Image THIOREDOX-PWY BioCyc
Ensembl Genes ENSRNOG00000009088 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000013613 ENTREZGENE
  ENSRNOT00000013613.8 UniProtKB/TrEMBL
Gene3D-CATH 3.30.390.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7112649 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GSHR/TRXR-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nuc-diS_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_OxRdtase_I_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin/glutathione_Rdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93353 IMAGE-MGC_LOAD
NCBI Gene 58819 ENTREZGENE
PANTHER GLUTATHIONE REDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  THIOREDOXIN REDUCTASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Pyr_redox_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyr_redox_dim UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Txnrd1 PhenoGen
PIRSF Mercury_reductase_MerA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS FADPNR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PNDRDTASEI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PYRIDINE_REDOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000009088 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55424 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC205148
UniProt A6IFH4_RAT UniProtKB/TrEMBL
  A6IFH6_RAT UniProtKB/TrEMBL
  O89049 ENTREZGENE
  Q5U344 ENTREZGENE
  Q9JKZ3 ENTREZGENE
  Q9JKZ4 ENTREZGENE
  Q9R1I3 ENTREZGENE
  R9PXU4 ENTREZGENE, UniProtKB/TrEMBL
  TRXR1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q5U344 UniProtKB/Swiss-Prot
  Q9JKZ3 UniProtKB/Swiss-Prot
  Q9JKZ4 UniProtKB/Swiss-Prot
  Q9R1I3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Txnrd1  thioredoxin reductase 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference