Txnrd1 (thioredoxin reductase 1) - Rat Genome Database

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Gene: Txnrd1 (thioredoxin reductase 1) Rattus norvegicus
Analyze
Symbol: Txnrd1
Name: thioredoxin reductase 1
RGD ID: 61959
Description: Enables several functions, including NADPH peroxidase activity; mercury ion binding activity; and selenate reductase activity. Involved in several processes, including NADPH oxidation; cellular response to hyperoxia; and halogen metabolic process. Located in neuronal cell body. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human TXNRD1 (thioredoxin reductase 1); PARTICIPATES IN pyrimidine metabolic pathway; selenoamino acid metabolic pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: MGC93353; NADPH-dependent thioredoxin reductase; peroxidase TXNRD1; selenoprotein oxidoreductase; thioredoxin reductase 1, cytoplasmic; thioredoxin reductase TR1; Tr
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,717,620 - 22,802,553 (-)NCBIGRCr8
mRatBN7.2720,830,042 - 20,914,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,830,045 - 20,907,863 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx722,794,109 - 22,878,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,956,878 - 25,041,383 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,733,893 - 24,818,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,946,124 - 26,984,400 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,946,125 - 26,984,400 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,065,819 - 27,104,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,055,544 - 23,093,815 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,075,818 - 23,112,858 (-)NCBI
Celera718,009,974 - 18,048,177 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Txnrd1Ratamyotrophic lateral sclerosis susceptibilityISOTXNRD1 (Homo sapiens)5685032DNA:SNPs:intron:rs6539137 and rs4630362 (human)RGD 
Txnrd1RatExperimental Diabetes Mellitus  IEP 5133714mRNA:altered expression:myocardium (rat)RGD 
Txnrd1RatHypoglossal Nerve Injuries  IEP 5133729mRNA and protein:increased expression:neuronRGD 
Txnrd1Ratmyocardial infarction  IEP 5134341mRNA:decreased expression:heart left ventricle (rat)RGD 
Txnrd1RatReperfusion Injury  IEP 5685028mRNA:decreased expression:spinal cordRGD 
Txnrd1RatReperfusion Injury  IEP 5685030mRNA:decreased expression:cerebral cortexRGD 
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Original Reference(s)
Txnrd1Ratadenoma  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18483336
Txnrd1Ratautism spectrum disorder  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Txnrd1RatCarcinoma, Lewis Lung  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16565519
Txnrd1RatColorectal Neoplasms  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18483336
Txnrd1Ratcongestive heart failure  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36071497
Txnrd1Ratcontact dermatitis  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Txnrd1Ratepilepsy  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19499324
Txnrd1RatMesothelioma  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17316382
Txnrd1RatMyocardial Ischemia  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
Txnrd1Ratosteoarthritis  ISOTXNRD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18784066
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Original Reference(s)
Txnrd1Rat(+)-catechin decreases activityEXP 6480464Catechin results in decreased activity of TXNRD1 protein modified formCTDPMID:16618767
Txnrd1Rat(+)-catechin multiple interactionsISOTXNRD1 (Homo sapiens)6480464[Oxygen deficiency co-treated with Catechin] results in increased expression of TXNRD1 mRNA and Catechin inhibits the reaction [Oxygen deficiency results in decreased expression of TXNRD1 protein]CTDPMID:35883890
Txnrd1Rat(+)-taxifolin increases expressionISOTXNRD1 (Homo sapiens)6480464taxifolin results in increased expression of TXNRD1 mRNACTDPMID:17541156
Txnrd1Rat(+)-taxifolin decreases activityEXP 6480464taxifolin results in decreased activity of TXNRD1 protein modified formCTDPMID:16618767
Txnrd1Rat(+/-)-Aegeline multiple interactionsISOTxnrd1 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNACTDPMID:28843594
Txnrd1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOTxnrd1 (Mus musculus)6480464epigallocatechin gallate affects the expression of and affects the activity of TXNRD1 proteinCTDPMID:25585349
Txnrd1Rat(-)-epigallocatechin 3-gallate increases expressionISOTxnrd1 (Mus musculus)6480464epigallocatechin gallate results in increased expression of TXNRD1 mRNACTDPMID:25585349
Txnrd1Rat(-)-quinic acid multiple interactionsISOTXNRD1 (Homo sapiens)6480464[Hydrogen Peroxide co-treated with Quinic Acid analog] results in increased expression of TXNRD1 mRNACTDPMID:21751221
Txnrd1Rat(1->4)-beta-D-glucan multiple interactionsISOTxnrd1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of TXNRD1 mRNACTDPMID:36331819
Txnrd1Rat(E)-cinnamyl alcohol increases expressionISOTXNRD1 (Homo sapiens)6480464cinnamyl alcohol results in increased expression of TXNRD1 mRNACTDPMID:20566472
Txnrd1Rat(E)-cinnamyl alcohol increases expressionISOTxnrd1 (Mus musculus)6480464cinnamyl alcohol results in increased expression of TXNRD1 mRNACTDPMID:23445166
Txnrd1Rat(R)-lipoic acid increases reductionISOTXNRD1 (Homo sapiens)6480464TXNRD1 protein results in increased reduction of Thioctic AcidCTDPMID:21172426
Txnrd1Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [Mercuric Chloride results in decreased activity of TXNRD1 protein]CTDPMID:20810785
Txnrd1Rat(RS)-coclaurine multiple interactionsISOTxnrd1 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNACTDPMID:28843594
Txnrd1Rat(RS)-norcoclaurine multiple interactionsISOTxnrd1 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNACTDPMID:28843594
Txnrd1Rat(S)-coclaurine multiple interactionsISOTxnrd1 (Mus musculus)6480464[Caffeine co-treated with coclaurine co-treated with aegeline co-treated with higenamine co-treated with Yohimbine co-treated with Hydrolyzable Tannins] results in increased expression of TXNRD1 mRNACTDPMID:28843594
Txnrd1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of TXNRD1 mRNACTDPMID:17984292
Txnrd1Rat1,2-dimethylhydrazine multiple interactionsISOTxnrd1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of TXNRD1 mRNACTDPMID:22206623
Txnrd1Rat1,2-dimethylhydrazine multiple interactionsEXP 6480464[1 and 2-Dimethylhydrazine co-treated with morin] results in increased expression of TXNRD1 mRNACTDPMID:32028820
Txnrd1Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of TXNRD1 mRNACTDPMID:32028820

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Biological Process
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Original Reference(s)
Txnrd1Ratbenzene-containing compound metabolic process  IDA 51337285 and 5'-dithiobis-2-nitrobenzoic acid DTNBRGD 
Txnrd1Ratcell population proliferation acts_upstream_of_or_withinISOTxnrd1 (Mus musculus)1624291MGI:3574773 PMID:15713651RGDPMID:15713651
Txnrd1Ratcell population proliferation acts_upstream_of_or_withinIEAUniProtKB:Q9JMH6 and ensembl:ENSMUSP000000204841600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1Ratcell redox homeostasis involved_inIEAInterPro:IPR0469521600115GO_REF:0000002InterProGO_REF:0000002
Txnrd1Ratcell redox homeostasis involved_inIBACGD:CAL0000184081 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Txnrd1Ratcellular oxidant detoxification involved_inIEAGO:00047911600115GO_REF:0000108GOCGO_REF:0000108
Txnrd1Ratcellular oxidant detoxification involved_inIEAGO:00501371600115GO_REF:0000108GOCGO_REF:0000108
Txnrd1Ratcellular response to copper ion  IEP 5130971 RGD 
Txnrd1Ratcellular response to hyperoxia  IEP 5133704 RGD 
Txnrd1Ratgastrulation acts_upstream_of_or_withinISOTxnrd1 (Mus musculus)1624291MGI:3722092 PMID:17697936RGDPMID:17697936
Txnrd1Ratgastrulation acts_upstream_of_or_withinIEAUniProtKB:Q9JMH6 and ensembl:ENSMUSP000000204841600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1Rathalogen metabolic process  IEP 5133705iodineRGD 
Txnrd1Rathydrogen peroxide catabolic process  IMP 634378 RGD 
Txnrd1Ratmesoderm formation acts_upstream_of_or_withinISOTxnrd1 (Mus musculus)1624291MGI:3722092 PMID:17697936RGDPMID:17697936
Txnrd1Ratmesoderm formation acts_upstream_of_or_withinIEAUniProtKB:Q9JMH6 and ensembl:ENSMUSP000000204841600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1Ratpositive regulation of apoptotic process  IMP 5134338 RGD 
Txnrd1Ratresponse to axon injury  IEP 5133729 RGD 
Txnrd1Ratresponse to hyperoxia  IEP 5133717 RGD 
Txnrd1Ratresponse to oxidative stress  IDA 634375 RGD 
Txnrd1Ratresponse to oxidative stress involved_inIEAARBA:ARBA000262731600115GO_REF:0000117UniProtGO_REF:0000117
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Cellular Component
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Original Reference(s)
Txnrd1Ratcytoplasm located_inIEAUniProtKB:Q9JMH6 and ensembl:ENSMUSP000000204841600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Txnrd1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Txnrd1Ratcytoplasm located_inISOTxnrd1 (Mus musculus)1624291 PMID:10721726RGDPMID:10721726
Txnrd1Ratcytoplasm is_active_inIBAFB:FBgn0020653 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Txnrd1Ratcytosol located_inISOTxnrd1 (Mus musculus)1624291 PMID:11259642RGDPMID:11259642
Txnrd1Ratcytosol located_inIEAUniProtKB:Q9JMH6 and ensembl:ENSMUSP000000204841600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1Ratcytosol is_active_inIBAMGI:1354175 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Txnrd1Ratfibrillar center located_inIEAUniProtKB:Q16881 and ensembl:ENSP000004345161600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1Ratfibrillar center located_inISOTXNRD1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Txnrd1Ratmitochondrion is_active_inIBAFB:FBgn0020653 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Txnrd1Ratneuronal cell body  IDA 5133712 RGD 
Txnrd1Ratnucleoplasm located_inIEAUniProtKB:Q16881 and ensembl:ENSP000004345161600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1Ratnucleoplasm located_inISOTXNRD1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Txnrd1Ratnucleus located_inISOTxnrd1 (Mus musculus)1624291 PMID:10721726RGDPMID:10721726
Txnrd1Ratnucleus located_inIEAUniProtKB:Q9JMH6 and ensembl:ENSMUSP000000204841600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Original Reference(s)
Txnrd1RatFAD binding enablesIEAUniProtKB:Q16881 and ensembl:ENSP000004345161600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1RatFAD binding enablesISOTXNRD1 (Homo sapiens)1624291 PMID:8577704RGDPMID:8577704
Txnrd1RatFAD binding enablesISSUniProtKB:Q168811600115GO_REF:0000024UniProtGO_REF:0000024
Txnrd1Ratflavin adenine dinucleotide binding enablesIEAInterPro:IPR0469521600115GO_REF:0000002InterProGO_REF:0000002
Txnrd1Ratidentical protein binding  IPITxnrd1 (Rattus norvegicus)5133693homodimerizationRGD 
Txnrd1Ratidentical protein binding enablesISOTXNRD1 (Homo sapiens)1624291 PMID:8577704RGDPMID:8577704
Txnrd1Ratidentical protein binding enablesIEAUniProtKB:Q16881 and ensembl:ENSP000004345161600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1Ratidentical protein binding  IPITxnrd1 (Rattus norvegicus)5134339homotetramerizationRGD 
Txnrd1Ratmercury ion binding  IDA 5133710 RGD 
Txnrd1RatNAD(P)H oxidase H2O2-forming activity  IDA 5133691 RGD 
Txnrd1RatNADPH peroxidase activity enablesIEAUniProtKB:Q16881 and ensembl:ENSP000004345161600115GO_REF:0000107EnsemblGO_REF:0000107
Txnrd1RatNADPH peroxidase activity enablesIEARHEA:151731600115GO_REF:0000116RHEAGO_REF:0000116
Txnrd1RatNADPH peroxidase activity enablesISOTXNRD1 (Homo sapiens)1624291 PMID:10849437RGDPMID:10849437
Txnrd1RatNADPH peroxidase activity enablesIDA 634378PMID:10849437UniProt 
Txnrd1Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Txnrd1Ratoxidoreductase activity enablesIEAInterPro:IPR001100 and InterPro:IPR0237531600115GO_REF:0000002InterProGO_REF:0000002
Txnrd1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Txnrd1Ratoxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor enablesIEAInterPro:IPR0129991600115GO_REF:0000002InterProGO_REF:0000002
Txnrd1Ratprotein binding enablesISOTXNRD1 (Homo sapiens) and UniProtKB:Q16881-41624291UniProtKB:P03372 more ...RGDPMID:15199063
Txnrd1Ratprotein binding enablesISOTXNRD1 (Homo sapiens)1624291UniProtKB:Q03135 and PMID:19820694RGDPMID:19820694
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Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Txnrd1Ratpyrimidine metabolic pathway  IEA 6907045 KEGGrno:00240
Txnrd1Ratselenoamino acid metabolic pathway  IEA 6907045 KEGGrno:00450

BioCyc Pathways


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Reference Title
Reference Citation
1. Rapid induction of cell death by selenium-compromised thioredoxin reductase 1 but not by the fully active enzyme containing selenocysteine. Anestal K and Arner ES, J Biol Chem. 2003 May 2;278(18):15966-72. Epub 2003 Feb 6.
2. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
3. Modulation of ascorbic acid metabolism by cytochrome P450 induction revealed by metabonomics and transcriptional profiling. Aranibar N, etal., Magn Reson Chem. 2009 Dec;47 Suppl 1:S12-9.
4. High-level expression in Escherichia coli of selenocysteine-containing rat thioredoxin reductase utilizing gene fusions with engineered bacterial-type SECIS elements and co-expression with the selA, selB and selC genes. Arner ES, etal., J Mol Biol 1999 Oct 8;292(5):1003-16.
5. Effects of selenite and chelating agents on mammalian thioredoxin reductase inhibited by mercury: implications for treatment of mercury poisoning. Carvalho CM, etal., FASEB J. 2011 Jan;25(1):370-81. Epub 2010 Sep 1.
6. Crystal structure and catalysis of the selenoprotein thioredoxin reductase 1. Cheng Q, etal., J Biol Chem. 2009 Feb 6;284(6):3998-4008. Epub 2008 Dec 3.
7. Functional expression of rat thioredoxin reductase: selenocysteine insertion sequence element is essential for the active enzyme. Fujiwara N, etal., Biochem J 1999 Jun 1;340 ( Pt 2):439-44.
8. Thioredoxin reductase 1 is upregulated in atherosclerotic plaques: specific induction of the promoter in human macrophages by oxidized low-density lipoproteins. Furman C, etal., Free Radic Biol Med. 2004 Jul 1;37(1):71-85.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Simultaneous expression of glutathione, thioredoxin-1, and their reductases in nerve transected hypoglossal motor neurons of rat. Hama I, etal., Brain Res. 2010 Jan 8;1306:1-7. Epub 2009 Oct 13.
11. Motexafin gadolinium, a tumor-selective drug targeting thioredoxin reductase and ribonucleotide reductase. Hashemy SI, etal., J Biol Chem. 2006 Apr 21;281(16):10691-7. Epub 2006 Feb 14.
12. Selective targeting of selenocysteine in thioredoxin reductase by the half mustard 2-chloroethyl ethyl sulfide in lung epithelial cells. Jan YH, etal., Chem Res Toxicol. 2010 Jun 21;23(6):1045-53.
13. Identification and characterization of TRP14, a thioredoxin-related protein of 14 kDa. New insights into the specificity of thioredoxin function. Jeong W, etal., J Biol Chem. 2004 Jan 30;279(5):3142-50. Epub 2003 Nov 7.
14. Protective effect of tetraethyl pyrazine against focal cerebral ischemia/reperfusion injury in rats: therapeutic time window and its mechanism. Jia J, etal., Thromb Res. 2009 Mar;123(5):727-30. Epub 2009 Jan 6.
15. Antioxidant defenses in the rat placenta in late gestation: increased labyrinthine expression of superoxide dismutases, glutathione peroxidase 3, and uncoupling protein 2. Jones ML, etal., Biol Reprod. 2010 Aug 1;83(2):254-60. Epub 2010 Apr 14.
16. Molecular cloning and characterization of a mitochondrial selenocysteine-containing thioredoxin reductase from rat liver. Lee SR, etal., J Biol Chem 1999 Feb 19;274(8):4722-34.
17. Regulation of Kv4 channel expression in failing rat heart by the thioredoxin system. Li X, etal., Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H416-24. Epub 2008 May 30.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. Thioredoxin reductase 1 haplotypes modify familial amyotrophic lateral sclerosis onset. Mitchell J, etal., Free Radic Biol Med. 2009 Jan 15;46(2):202-11. Epub 2008 Oct 22.
20. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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PMID:8889548   PMID:10721726   PMID:10769168   PMID:11259642   PMID:11481439   PMID:12477932   PMID:15713651   PMID:15879598   PMID:15901730   PMID:16750198   PMID:17023680   PMID:17291446  
PMID:17394422   PMID:17697936   PMID:18382651   PMID:18570454   PMID:18614015   PMID:19351701   PMID:20126492   PMID:20524817   PMID:20536427   PMID:21903721   PMID:22177986   PMID:22377061  
PMID:23106098   PMID:23629660   PMID:23802942   PMID:24853413   PMID:24984066   PMID:25055978   PMID:25611390   PMID:26252619   PMID:28551108   PMID:28684416   PMID:32867364   PMID:33649852  



Txnrd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8722,717,620 - 22,802,553 (-)NCBIGRCr8
mRatBN7.2720,830,042 - 20,914,990 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl720,830,045 - 20,907,863 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx722,794,109 - 22,878,689 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0724,956,878 - 25,041,383 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0724,733,893 - 24,818,472 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0726,946,124 - 26,984,400 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl726,946,125 - 26,984,400 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0727,065,819 - 27,104,095 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4723,055,544 - 23,093,815 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1723,075,818 - 23,112,858 (-)NCBI
Celera718,009,974 - 18,048,177 (-)NCBICelera
Cytogenetic Map7q13NCBI
TXNRD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3812104,215,779 - 104,350,307 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl12104,215,779 - 104,350,307 (+)EnsemblGRCh38hg38GRCh38
GRCh3712104,609,557 - 104,744,085 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3612103,133,689 - 103,268,192 (+)NCBINCBI36Build 36hg18NCBI36
Build 3412103,183,193 - 103,246,528NCBI
Celera12104,273,262 - 104,408,523 (+)NCBICelera
Cytogenetic Map12q23.3NCBI
HuRef12101,669,268 - 101,804,294 (+)NCBIHuRef
CHM1_112104,575,396 - 104,709,877 (+)NCBICHM1_1
T2T-CHM13v2.012104,177,472 - 104,311,962 (+)NCBIT2T-CHM13v2.0
Txnrd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391082,669,785 - 82,733,558 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1082,669,785 - 82,733,546 (+)EnsemblGRCm39 Ensembl
GRCm381082,833,951 - 82,897,724 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1082,833,951 - 82,897,712 (+)EnsemblGRCm38mm10GRCm38
MGSCv371082,296,696 - 82,360,469 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361082,288,978 - 82,327,511 (+)NCBIMGSCv36mm8
Celera1084,818,861 - 84,882,466 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1040.66NCBI
Txnrd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540538,903,918 - 38,927,410 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540538,863,762 - 38,928,615 (+)NCBIChiLan1.0ChiLan1.0
TXNRD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210112,278,071 - 112,412,731 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112112,274,278 - 112,409,127 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v012101,862,703 - 101,925,104 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.112105,258,828 - 105,321,112 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl12105,187,128 - 105,321,112 (+)Ensemblpanpan1.1panPan2
TXNRD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11033,904,065 - 34,021,549 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1033,886,343 - 34,021,696 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1033,824,269 - 33,941,521 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01034,747,423 - 34,864,919 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1034,747,416 - 34,864,924 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11034,482,294 - 34,599,587 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01034,765,845 - 34,883,396 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01034,960,435 - 35,077,894 (-)NCBIUU_Cfam_GSD_1.0
Txnrd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494517,175,082 - 17,233,863 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649210,187,206 - 10,225,989 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649210,185,096 - 10,244,466 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TXNRD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl580,172,260 - 80,236,219 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1580,170,334 - 80,213,889 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2583,657,828 - 83,701,655 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap5q2.3NCBI
TXNRD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11199,375,740 - 99,559,929 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1199,490,597 - 99,560,267 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037145,442,330 - 145,506,477 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Txnrd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247504,443,915 - 4,510,380 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247504,444,318 - 4,536,384 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Txnrd1
1270 total Variants

Predicted Target Of
Summary Value
Count of predictions:229
Count of miRNA genes:156
Interacting mature miRNAs:187
Transcripts:ENSRNOT00000013613
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 29 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat

1 to 10 of 29 rows
D7Wox51  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,857,409 - 20,857,568 (+)MAPPERmRatBN7.2
Rnor_6.0726,973,491 - 26,973,649NCBIRnor6.0
Rnor_5.0727,093,186 - 27,093,344UniSTSRnor5.0
RGSC_v3.4723,082,906 - 23,083,064UniSTSRGSC3.4
Celera718,037,270 - 18,037,428UniSTS
Cytogenetic Map7q13UniSTS
AW527618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,860,129 - 20,860,375 (+)MAPPERmRatBN7.2
Rnor_6.0726,976,211 - 26,976,456NCBIRnor6.0
Rnor_5.0727,095,906 - 27,096,151UniSTSRnor5.0
RGSC_v3.4723,085,626 - 23,085,871UniSTSRGSC3.4
Celera718,039,990 - 18,040,235UniSTS
RH 3.4 Map7117.8UniSTS
Cytogenetic Map7q13UniSTS
RH137037  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,830,099 - 20,830,319 (+)MAPPERmRatBN7.2
Rnor_6.0726,946,182 - 26,946,401NCBIRnor6.0
Rnor_5.0727,065,877 - 27,066,096UniSTSRnor5.0
RGSC_v3.4723,055,602 - 23,055,821UniSTSRGSC3.4
Celera718,010,032 - 18,010,251UniSTS
RH 3.4 Map7118.3UniSTS
Cytogenetic Map7q13UniSTS
RH138724  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,839,177 - 20,839,351 (+)MAPPERmRatBN7.2
Rnor_6.0726,955,263 - 26,955,436NCBIRnor6.0
Rnor_5.0727,074,958 - 27,075,131UniSTSRnor5.0
RGSC_v3.4723,064,678 - 23,064,851UniSTSRGSC3.4
Celera718,019,128 - 18,019,301UniSTS
RH 3.4 Map7117.25UniSTS
Cytogenetic Map7q13UniSTS
AW527618  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2720,860,268 - 20,860,376 (+)MAPPERmRatBN7.2
Rnor_6.0726,976,350 - 26,976,457NCBIRnor6.0
Rnor_5.0727,096,045 - 27,096,152UniSTSRnor5.0
RGSC_v3.4723,085,765 - 23,085,872UniSTSRGSC3.4
Celera718,040,129 - 18,040,236UniSTS
RH 3.4 Map7117.8UniSTS
Cytogenetic Map7q13UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 19 of 19 rows
RefSeq Transcripts NM_001351981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001351983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001351984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031614 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA955679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF108213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF189711 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF220760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF220761 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085726 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF415095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB579100 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ090798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225805 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232901 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U63923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 19 of 19 rows

Ensembl Acc Id: ENSRNOT00000013613   ⟹   ENSRNOP00000013612
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl720,830,045 - 20,907,863 (-)Ensembl
Rnor_6.0 Ensembl726,946,125 - 26,984,400 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089545   ⟹   ENSRNOP00000069166
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl726,946,125 - 26,983,172 (-)Ensembl
RefSeq Acc Id: NM_001351981   ⟹   NP_001338910
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,717,620 - 22,755,904 (-)NCBI
mRatBN7.2720,830,042 - 20,868,332 (-)NCBI
RefSeq Acc Id: NM_001351983   ⟹   NP_001338912
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,717,620 - 22,764,851 (-)NCBI
mRatBN7.2720,830,042 - 20,877,280 (-)NCBI
RefSeq Acc Id: NM_001351984   ⟹   NP_001338913
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,717,620 - 22,802,553 (-)NCBI
mRatBN7.2720,830,042 - 20,914,990 (-)NCBI
RefSeq Acc Id: NM_031614   ⟹   NP_113802
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8722,717,620 - 22,755,904 (-)NCBI
mRatBN7.2720,830,042 - 20,868,332 (-)NCBI
Rnor_6.0726,946,124 - 26,984,400 (-)NCBI
Rnor_5.0727,065,819 - 27,104,095 (-)NCBI
RGSC_v3.4723,055,544 - 23,093,815 (-)RGD
Celera718,009,974 - 18,048,177 (-)RGD
Sequence:
RefSeq Acc Id: NP_113802   ⟸   NM_031614
- Peptide Label: isoform 1
- UniProtKB: Q9R1I3 (UniProtKB/Swiss-Prot),   Q9JKZ4 (UniProtKB/Swiss-Prot),   Q9JKZ3 (UniProtKB/Swiss-Prot),   Q5U344 (UniProtKB/Swiss-Prot),   O89049 (UniProtKB/Swiss-Prot),   R9PXU4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000069166   ⟸   ENSRNOT00000089545
Ensembl Acc Id: ENSRNOP00000013612   ⟸   ENSRNOT00000013613
RefSeq Acc Id: NP_001338913   ⟸   NM_001351984
- Peptide Label: isoform 2
- UniProtKB: Q9R1I3 (UniProtKB/Swiss-Prot),   Q9JKZ4 (UniProtKB/Swiss-Prot),   Q9JKZ3 (UniProtKB/Swiss-Prot),   Q5U344 (UniProtKB/Swiss-Prot),   O89049 (UniProtKB/Swiss-Prot),   R9PXU4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001338912   ⟸   NM_001351983
- Peptide Label: isoform 1
- UniProtKB: Q9R1I3 (UniProtKB/Swiss-Prot),   Q9JKZ4 (UniProtKB/Swiss-Prot),   Q9JKZ3 (UniProtKB/Swiss-Prot),   Q5U344 (UniProtKB/Swiss-Prot),   O89049 (UniProtKB/Swiss-Prot),   R9PXU4 (UniProtKB/TrEMBL)
FAD/NAD(P)-binding   Pyridine nucleotide-disulphide oxidoreductase


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13695110
Promoter ID:EPDNEW_R5635
Type:multiple initiation site
Name:Txnrd1_1
Description:thioredoxin reductase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0726,984,402 - 26,984,462EPDNEW


1 to 40 of 44 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-34570 BioCyc
BioCyc Pathway THIOREDOX-PWY [thioredoxin pathway] BioCyc
BioCyc Pathway Image THIOREDOX-PWY BioCyc
Ensembl Genes ENSRNOG00000009088 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000013613 ENTREZGENE
Gene3D-CATH 3.30.390.30 UniProtKB/Swiss-Prot
  3.50.50.60 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7112649 IMAGE-MGC_LOAD
InterPro FAD/NAD-bd_sf UniProtKB/Swiss-Prot
  FAD/NAD-binding_dom UniProtKB/Swiss-Prot
  FAD/NAD-linked_Rdtase_dimer_sf UniProtKB/Swiss-Prot
  GSHR/TRXR-like UniProtKB/Swiss-Prot
  Pyr_nuc-diS_OxRdtase UniProtKB/Swiss-Prot
  Pyr_nucl-diS_OxRdtase_dimer UniProtKB/Swiss-Prot
  Pyr_OxRdtase_I_AS UniProtKB/Swiss-Prot
  Thioredoxin/glutathione_Rdtase UniProtKB/Swiss-Prot
MGC_CLONE MGC:93353 IMAGE-MGC_LOAD
NCBI Gene 58819 ENTREZGENE
PANTHER GLUTATHIONE REDUCTASE UniProtKB/Swiss-Prot
  THIOREDOXIN REDUCTASE 1 UniProtKB/Swiss-Prot
Pfam Pyr_redox_2 UniProtKB/Swiss-Prot
  Pyr_redox_dim UniProtKB/Swiss-Prot
PhenoGen Txnrd1 PhenoGen
PIRSF Mercury_reductase_MerA UniProtKB/Swiss-Prot
PRINTS FADPNR UniProtKB/Swiss-Prot
  PNDRDTASEI UniProtKB/Swiss-Prot
PROSITE PYRIDINE_REDOX_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009088 RatGTEx
Superfamily-SCOP SSF51905 UniProtKB/Swiss-Prot
  SSF55424 UniProtKB/Swiss-Prot
TIGR TC205148
UniProt A6IFH4_RAT UniProtKB/TrEMBL
  A6IFH6_RAT UniProtKB/TrEMBL
  O89049 ENTREZGENE
  Q5U344 ENTREZGENE
  Q9JKZ3 ENTREZGENE
  Q9JKZ4 ENTREZGENE
  Q9R1I3 ENTREZGENE
  R9PXU4 ENTREZGENE, UniProtKB/TrEMBL
  TRXR1_RAT UniProtKB/Swiss-Prot
1 to 40 of 44 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Txnrd1  thioredoxin reductase 1       Name updated 70584 APPROVED

Note Type Note Reference