Psmc3 (proteasome 26S subunit, ATPase 3) - Rat Genome Database

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Gene: Psmc3 (proteasome 26S subunit, ATPase 3) Rattus norvegicus
Analyze
Symbol: Psmc3
Name: proteasome 26S subunit, ATPase 3
RGD ID: 61905
Description: Predicted to enable identical protein binding activity and proteasome-activating activity. Predicted to be involved in modulation by host of viral transcription; positive regulation of transcription by RNA polymerase II; and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within blastocyst development. Located in perinuclear region of cytoplasm. Orthologous to human PSMC3 (proteasome 26S subunit, ATPase 3); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2,4-trimethylbenzene; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 26S protease regulatory subunit 6A; 26S proteasome AAA-ATPase subunit RPT5; 26S proteasome regulatory subunit 6A; proteasome (prosome, macropain) 26S subunit, ATPase 3; proteasome 26S subunit ATPase 3; spermatogenic cell/sperm-associated TAT-binding protein homolog SATA; TAT-binding protein 1; TBP-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,487,643 - 97,493,025 (+)NCBIGRCr8
mRatBN7.2377,031,825 - 77,037,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,031,825 - 77,043,358 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,510,318 - 80,515,699 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,109,333 - 89,114,714 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,960,503 - 86,965,883 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,876,938 - 79,882,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,876,938 - 79,882,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,585,691 - 86,591,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,413,567 - 75,418,948 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,309,938 - 75,315,317 (+)NCBI
Celera376,240,531 - 76,245,912 (+)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
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Evidence
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Reference
Notes
Source
Original Reference(s)
Psmc3Ratcataract  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Congenital cataractClinVarPMID:32500975
Psmc3Ratcongenital disorder of glycosylation type IIc  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Rambam Hasharon syndromeClinVarPMID:16455955 more ...
Psmc3RatDEAFNESS, CATARACT, IMPAIRED INTELLECTUAL DEVELOPMENT, AND POLYNEUROPATHY  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Deafness more ...ClinVarPMID:32500975
Psmc3RatDevelopmental Disabilities  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Global developmental delayClinVar 
Psmc3Ratfetal akinesia deformation sequence syndrome 1  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Fetal akinesia deformation sequence 1ClinVarPMID:17686188 and PMID:28492532
Psmc3Ratgenetic disease  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:28689658
Psmc3Rathypertrophic cardiomyopathy  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hypertrophic cardiomyopathyClinVarPMID:28492532
Psmc3Ratintellectual disability  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
Psmc3RatNeurodevelopmental Disorders  ISOPSMC3 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868 more ...
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Original Reference(s)
Psmc3Rathuman immunodeficiency virus infectious disease  ISOPSMC3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15308739
Object Symbol
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Term
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Original Reference(s)
Psmc3RatDEAFNESS, CATARACT, IMPAIRED INTELLECTUAL DEVELOPMENT, AND POLYNEUROPATHY  ISOPSMC3 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Reference
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Original Reference(s)
Psmc3Rat(1->4)-beta-D-glucan multiple interactionsISOPsmc3 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PSMC3 mRNACTDPMID:36331819
Psmc3Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of PSMC3 mRNACTDPMID:17984292
Psmc3Rat1,2,4-trimethylbenzene decreases expressionEXP 6480464pseudocumene results in decreased expression of PSMC3 proteinCTDPMID:17337753
Psmc3Rat1,2-dimethylhydrazine increases expressionISOPsmc3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of PSMC3 mRNACTDPMID:22206623
Psmc3Rat1,2-dimethylhydrazine multiple interactionsISOPsmc3 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of PSMC3 mRNACTDPMID:22206623
Psmc3Rat14-Deoxy-11,12-didehydroandrographolide decreases expressionISOPSMC3 (Homo sapiens)648046414-deoxy-11 and 12-didehydroandrographolide results in decreased expression of PSMC3 mRNACTDPMID:22101062
Psmc3Rat17alpha-ethynylestradiol multiple interactionsISOPsmc3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMC3 mRNACTDPMID:17942748
Psmc3Rat17beta-estradiol increases expressionISOPSMC3 (Homo sapiens)6480464Estradiol results in increased expression of PSMC3 mRNACTDPMID:19167446
Psmc3Rat17beta-estradiol increases expressionISOPsmc3 (Mus musculus)6480464Estradiol results in increased expression of PSMC3 mRNACTDPMID:39298647
Psmc3Rat17beta-hydroxy-17-methylestra-4,9,11-trien-3-one increases expressionISOPSMC3 (Homo sapiens)6480464Metribolone results in increased expression of PSMC3 proteinCTDPMID:17152098
Psmc3Rat1H-pyrazole increases expressionISOPsmc3 (Mus musculus)6480464pyrazole results in increased expression of PSMC3 mRNACTDPMID:17945193
Psmc3Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOPsmc3 (Mus musculus)64804642 more ...CTDPMID:30294300
Psmc3Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:31826744
Psmc3Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOPsmc3 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PSMC3 mRNACTDPMID:17942748
Psmc3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of PSMC3 mRNACTDPMID:33387578
Psmc3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of PSMC3 mRNACTDPMID:34747641
Psmc3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPsmc3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PSMC3 mRNACTDPMID:21570461
Psmc3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PSMC3 mRNACTDPMID:21215274
Psmc3Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Psmc3Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionISOPsmc3 (Mus musculus)64804642 more ...CTDPMID:18550172

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Biological Process

  

Cellular Component
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Original Reference(s)
Psmc3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Psmc3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Psmc3Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Psmc3Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Psmc3Ratnucleus located_inIEAUniProtKB:P17980 and ensembl:ENSP000002988521600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc3Ratnucleus located_inISOPSMC3 (Homo sapiens)1624291 PMID:2194290RGDPMID:2194290
Psmc3RatP-body located_inISSUniProtKB:O886851600115GO_REF:0000024UniProtGO_REF:0000024
Psmc3RatP-body located_inISOPsmc3 (Mus musculus)1624291 PMID:22078707RGDPMID:22078707
Psmc3RatP-body located_inIEAUniProtKB:O88685 and ensembl:ENSMUSP000000710541600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc3Ratperinuclear region of cytoplasm  IDA 2291798 RGD 
Psmc3Ratproteasome accessory complex part_ofISSUniProtKB:O886851600115GO_REF:0000024UniProtGO_REF:0000024
Psmc3Ratproteasome accessory complex part_ofIEAUniProtKB:O88685 and ensembl:ENSMUSP000000710541600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc3Ratproteasome accessory complex part_ofISOPsmc3 (Mus musculus)1624291 PMID:16857966RGDPMID:16857966
Psmc3Ratproteasome complex part_ofISOPSMC3 (Homo sapiens)1624291 PMID:17323924 and PMID:9464850RGDPMID:17323924 and PMID:9464850
Psmc3Ratproteasome complex part_ofIEAUniProtKB:P17980 and ensembl:ENSP000002988521600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc3Ratproteasome complex part_ofIEAUniProtKB-KW:KW-06471600115GO_REF:0000043UniProtGO_REF:0000043
Psmc3Ratproteasome regulatory particle, base subcomplex part_ofIBAFB:FBgn0015282 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 17 of 17 rows

Molecular Function
1 to 10 of 10 rows

  
Object Symbol
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Term
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Reference
Notes
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Original Reference(s)
Psmc3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Psmc3RatATP binding enablesIEAInterPro:IPR003959 and InterPro:IPR0039601600115GO_REF:0000002InterProGO_REF:0000002
Psmc3RatATP hydrolysis activity enablesIEAInterPro:IPR003593 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Psmc3Ratidentical protein binding enablesIEAUniProtKB:P17980 and ensembl:ENSP000002988521600115GO_REF:0000107EnsemblGO_REF:0000107
Psmc3Ratidentical protein binding enablesISOPSMC3 (Homo sapiens)1624291UniProtKB:P17980 more ...RGDPMID:25416956 and PMID:32296183
Psmc3Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Psmc3Ratproteasome-activating activity enablesIBAPANTHER:PTN000553037 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Psmc3Ratprotein binding  IPISnca (Rattus norvegicus)2291798 RGD 
Psmc3Ratprotein binding enablesIPIUniProtKB:A0A0G2K916 more ...11344934PMID:27191843UniProt 
Psmc3Ratprotein binding enablesISOPSMC3 (Homo sapiens)1624291UniProtKB:A8K2R3 more ...RGDPMID:16713569 more ...
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Imported Annotations - KEGG (archival)

Object Symbol
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Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Psmc3Ratubiquitin/proteasome degradation pathway  IEA 6907045 KEGGrno:03050

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#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat alpha-synuclein interacts with Tat binding protein 1, a component of the 26S proteasomal complex. Ghee M, etal., J Neurochem. 2000 Nov;75(5):2221-4.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing. Makino Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):1049-54.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. A protein associated with the manchette during rat spermiogenesis is encoded by a gene of the TBP-1-like subfamily with highly conserved ATPase and protease domains. Rivkin E, etal., Mol Reprod Dev 1997 Sep;48(1):77-89.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. The EARP Complex and Its Interactor EIPR-1 Are Required for Cargo Sorting to Dense-Core Vesicles. Topalidou I, etal., PLoS Genet. 2016 May 18;12(5):e1006074. doi: 10.1371/journal.pgen.1006074. eCollection 2016 May.
1 to 12 of 12 rows
PMID:2194290   PMID:8419915   PMID:9688553   PMID:10657252   PMID:10945464   PMID:16857966   PMID:17323924   PMID:19182904   PMID:19517565   PMID:19853614   PMID:19946888   PMID:21630459  
PMID:22078707   PMID:22871113   PMID:25416956   PMID:30053369   PMID:35352799  



Psmc3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8397,487,643 - 97,493,025 (+)NCBIGRCr8
mRatBN7.2377,031,825 - 77,037,207 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,031,825 - 77,043,358 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx380,510,318 - 80,515,699 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,109,333 - 89,114,714 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0386,960,503 - 86,965,883 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0379,876,938 - 79,882,319 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl379,876,938 - 79,882,319 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0386,585,691 - 86,591,072 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4375,413,567 - 75,418,948 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1375,309,938 - 75,315,317 (+)NCBI
Celera376,240,531 - 76,245,912 (+)NCBICelera
Cytogenetic Map3q24NCBI
PSMC3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,418,775 - 47,426,439 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,418,769 - 47,426,473 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,440,326 - 47,447,990 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361147,396,896 - 47,404,600 (-)NCBINCBI36Build 36hg18NCBI36
Build 341147,396,895 - 47,404,565NCBI
Celera1147,582,015 - 47,589,718 (-)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1147,139,662 - 47,147,028 (-)NCBIHuRef
CHM1_11147,439,552 - 47,447,251 (-)NCBICHM1_1
T2T-CHM13v2.01147,577,679 - 47,585,336 (-)NCBIT2T-CHM13v2.0
Psmc3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39290,884,361 - 90,889,783 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl290,884,354 - 90,896,714 (+)EnsemblGRCm39 Ensembl
GRCm38291,054,016 - 91,059,438 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,054,009 - 91,066,369 (+)EnsemblGRCm38mm10GRCm38
MGSCv37290,894,173 - 90,899,595 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36290,854,921 - 90,860,267 (+)NCBIMGSCv36mm8
Celera292,438,480 - 92,443,912 (+)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.44NCBI
Psmc3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955422837,573 - 845,341 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955422837,934 - 843,161 (+)NCBIChiLan1.0ChiLan1.0
PSMC3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2949,621,734 - 49,629,444 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11149,641,522 - 49,649,232 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01147,366,986 - 47,374,677 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11147,920,295 - 47,927,654 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1147,920,295 - 47,927,654 (-)Ensemblpanpan1.1panPan2
PSMC3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11842,212,083 - 42,218,958 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1840,942,640 - 40,949,498 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01842,867,799 - 42,874,682 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1842,867,947 - 42,874,677 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11842,354,412 - 42,361,285 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01841,909,294 - 41,916,243 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01842,638,826 - 42,645,702 (+)NCBIUU_Cfam_GSD_1.0
Psmc3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494719,699,233 - 19,705,397 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365621,810,864 - 1,823,077 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365621,810,883 - 1,817,040 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl215,166,306 - 15,193,047 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1215,185,482 - 15,191,189 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2216,392,149 - 16,397,835 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSMC3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1117,881,844 - 17,896,942 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038115,190,816 - 115,198,248 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247671,362,132 - 1,372,083 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247671,361,970 - 1,367,282 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Psmc3
19 total Variants

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:98
Interacting mature miRNAs:105
Transcripts:ENSRNOT00000015757
Prediction methods:Microtar, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)34382736490905114Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)35318469289878207Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)370653097121056321Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)353184593115665732Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)353184593115665732Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)347233211147415807Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000015757   ⟹   ENSRNOP00000015757
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,031,825 - 77,037,206 (+)Ensembl
Rnor_6.0 Ensembl379,876,938 - 79,882,319 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103724   ⟹   ENSRNOP00000082627
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,031,825 - 77,043,358 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104701   ⟹   ENSRNOP00000088016
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl377,031,825 - 77,037,206 (+)Ensembl
RefSeq Acc Id: NM_031595   ⟹   NP_113783
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,487,643 - 97,493,024 (+)NCBI
mRatBN7.2377,031,825 - 77,037,206 (+)NCBI
Rnor_6.0379,876,938 - 79,882,319 (+)NCBI
Rnor_5.0386,585,691 - 86,591,072 (+)NCBI
RGSC_v3.4375,413,567 - 75,418,948 (+)RGD
Celera376,240,531 - 76,245,912 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104795   ⟹   XP_038960723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8397,489,599 - 97,493,025 (+)NCBI
mRatBN7.2377,033,781 - 77,037,207 (+)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_113783 (Get FASTA)   NCBI Sequence Viewer  
  XP_038960723 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB70882 (Get FASTA)   NCBI Sequence Viewer  
  AAH62019 (Get FASTA)   NCBI Sequence Viewer  
  BAA11939 (Get FASTA)   NCBI Sequence Viewer  
  EDL79502 (Get FASTA)   NCBI Sequence Viewer  
  EDL79503 (Get FASTA)   NCBI Sequence Viewer  
  EDL79504 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015757
GenBank Protein Q63569 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_113783   ⟸   NM_031595
- UniProtKB: Q63569 (UniProtKB/Swiss-Prot),   P97638 (UniProtKB/Swiss-Prot),   Q6P6U2 (UniProtKB/TrEMBL),   A6HNA2 (UniProtKB/TrEMBL),   F7EY30 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015757   ⟸   ENSRNOT00000015757
RefSeq Acc Id: XP_038960723   ⟸   XM_039104795
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000088016   ⟸   ENSRNOT00000104701
Ensembl Acc Id: ENSRNOP00000082627   ⟸   ENSRNOT00000103724
AAA+ ATPase

Name Modeler Protein Id AA Range Protein Structure
AF-Q63569-F1-model_v2 AlphaFold Q63569 1-439 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13692204
Promoter ID:EPDNEW_R2729
Type:initiation region
Name:Psmc3_1
Description:proteasome 26S subunit, ATPase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0379,876,987 - 79,877,047EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-48753 BioCyc
Ensembl Genes ENSRNOG00000011414 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000015757 ENTREZGENE
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot
  2.40.50.140 UniProtKB/Swiss-Prot
  3.40.50.300 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5620971 IMAGE-MGC_LOAD
InterPro 26S_Proteasome_ATPase UniProtKB/Swiss-Prot
  AAA+_ATPase UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  ATPase_AAA_core UniProtKB/Swiss-Prot
  ATPase_AAA_CS UniProtKB/Swiss-Prot
  NA-bd_OB-fold UniProtKB/Swiss-Prot
  P-loop_NTPase UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
KEGG Report rno:29677 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72399 IMAGE-MGC_LOAD
NCBI Gene 29677 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/Swiss-Prot
Pfam AAA UniProtKB/Swiss-Prot
  AAA_lid_3 UniProtKB/Swiss-Prot
  Prot_ATP_ID_OB UniProtKB/Swiss-Prot
PhenoGen Psmc3 PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011414 RatGTEx
SMART AAA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot
UniProt A0A8I5ZUG8_RAT UniProtKB/TrEMBL
  A0A8I6A723_RAT UniProtKB/TrEMBL
  A6HNA1_RAT UniProtKB/TrEMBL
  A6HNA2 ENTREZGENE, UniProtKB/TrEMBL
  A6HNA3_RAT UniProtKB/TrEMBL
  F7EY30 ENTREZGENE, UniProtKB/TrEMBL
  P97638 ENTREZGENE
  PRS6A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P6U2 ENTREZGENE
UniProt Secondary P97638 UniProtKB/Swiss-Prot
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Psmc3  proteasome 26S subunit, ATPase 3  Psmc3  proteasome (prosome, macropain) 26S subunit, ATPase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Psmc3  proteasome (prosome, macropain) 26S subunit, ATPase 3       Name updated 70584 APPROVED

Note Type Note Reference