Ftl1 (ferritin light chain 1) - Rat Genome Database

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Gene: Ftl1 (ferritin light chain 1) Rattus norvegicus
Analyze
Symbol: Ftl1
Name: ferritin light chain 1
RGD ID: 61813
Description: Predicted to enable ferric iron binding activity; ferrous iron binding activity; and identical protein binding activity. Involved in response to lead ion. Predicted to be located in autolysosome. Predicted to be part of ferritin complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in basal ganglia disease; hyperferritinemia-cataract syndrome; neurodegeneration with brain iron accumulation 3; and neurodegenerative disease. Orthologous to human FTL (ferritin light chain); PARTICIPATES IN iron storage pathway; porphyrin and chlorophyll metabolic pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ferritin L subunit 1; ferritin light chain; ferritin, light polypeptide; Ftl
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Ftl1-ps14  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,072,858 - 105,074,705 (-)NCBIGRCr8
mRatBN7.2195,936,387 - 95,938,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,257,727 - 44,258,273 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl195,936,387 - 95,939,725 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl261,543,323 - 61,578,556 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,321,817 - 101,323,664 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,794,493 - 109,796,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,084,890 - 103,086,737 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,448,190 - 101,450,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,527,136 - 102,528,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,929,248 - 95,931,092 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,007,368 - 96,009,121 (-)NCBI
Celera190,192,302 - 90,194,146 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Ftl1Ratbasal ganglia disease  ISOFTL (Homo sapiens)5509839DNA:insertion:exon:460_461insA(human)RGD 
Ftl1RatCOVID-19 severityISOFTL (Homo sapiens)30310229protein:increased expression:serum (human)RGD 
Ftl1RatCOVID-19 severityISOFTL (Homo sapiens)32698682associated with hyperglycemia and protein:increased expression:serum (human)RGD 
Ftl1Rathyperferritinemia-cataract syndrome  ISOFTL (Homo sapiens)1598966DNA:deletion:5' utr: (human)RGD 
Ftl1Rathyperferritinemia-cataract syndrome  ISOFTL (Homo sapiens)5509864DNA:mutations:5'utr:RGD 
Ftl1Ratneurodegeneration with brain iron accumulation 3  ISOFTL (Homo sapiens)5509861DNA:mutations:exon:RGD 
Ftl1Ratneurodegeneration with brain iron accumulation 3  ISOFTL (Homo sapiens)5509859DNA:insertion:exon:460_461insA(human)RGD 
Ftl1Ratneurodegeneration with brain iron accumulation 3  ISOFTL (Homo sapiens)5509860DNA:duplication:cds:458dupA(human)RGD 
Ftl1Ratneurodegenerative disease  ISOFTL (Homo sapiens)5509863DNA:insertion:exon:498_499insTCRGD 
Ftl1Ratneurodegenerative disease  ISOFtl1 (Mus musculus)5509863protein:increased expression:brainRGD 
Ftl1Ratneurodegenerative disease  ISOFTL (Homo sapiens)5509840DNA:insertion:exon:498_499InsTC (human)RGD 
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Original Reference(s)
Ftl1Ratabdominal aortic aneurysm  ISOFTL (Homo sapiens)8554872ClinVar Annotator: match by term: sporadic abdominal aortic aneurysmClinVarPMID:17182944 more ...
Ftl1Ratgenetic disease  ISOFTL (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:23940258 and PMID:28492532
Ftl1RatGlycogen Storage Disease 0, Muscle  ISOFTL (Homo sapiens)8554872ClinVar Annotator: match by term: Muscle glycogen synthase deficiencyClinVarPMID:17182944 more ...
Ftl1Rathyperferritinemia-cataract syndrome  ISOFTL (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary hyperferritinemia with congenital cataractsClinVarPMID:10366790 more ...
Ftl1RatL-Ferritin Deficiency  ISOFTL (Homo sapiens)8554872ClinVar more ...ClinVarPMID:15173247 more ...
Ftl1Ratneurodegeneration with brain iron accumulation 3  ISOFTL (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11438811 more ...
1 to 12 of 12 rows
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Original Reference(s)
Ftl1RatChemical and Drug Induced Liver Injury  ISOFtl1 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25231249
Ftl1Ratdepressive disorder  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17063146
Ftl1Rathyperferritinemia-cataract syndrome  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ftl1Ratiron metabolism disease  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16822677
Ftl1RatKeloid  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20128793
Ftl1RatNeoplasm Invasiveness  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20390345
Ftl1RatNeoplasm Metastasis  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17085005
Ftl1RatNervous System Heredodegenerative Disorders  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16825958
Ftl1Ratneurodegeneration with brain iron accumulation 3  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Ftl1Ratneurodegenerative disease  ISOFtl1 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15964507
Ftl1Ratobesity  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20882379
Ftl1Ratosteoarthritis  ISOFTL (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18784066
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1 to 20 of 354 rows

  
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Original Reference(s)
Ftl1Rat(-)-alpha-phellandrene increases expressionISOFTL (Homo sapiens)6480464alpha phellandrene results in increased expression of FTL1 mRNA and alpha phellandrene results in increased expression of FTL2-PS mRNACTDPMID:25075043
Ftl1Rat(1->4)-beta-D-glucan multiple interactionsISOFtl1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of FTL1 mRNACTDPMID:36331819
Ftl1Rat(E)-cinnamyl alcohol increases expressionISOFTL (Homo sapiens)6480464cinnamyl alcohol results in increased expression of FTL mRNACTDPMID:20566472
Ftl1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of FTL1 mRNACTDPMID:17984292
Ftl1Rat1,2-dimethylhydrazine multiple interactionsISOFtl1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in increased expression of FTL1 mRNACTDPMID:22206623
Ftl1Rat1,3-benzothiazole-2-thiol increases expressionISOFTL (Homo sapiens)6480464captax results in increased expression of FTL mRNACTDPMID:24211530
Ftl1Rat1-aminobenzotriazole multiple interactionsISOFtl1 (Mus musculus)64804641-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of FTL1 protein]CTDPMID:32435916
Ftl1Rat1-chloro-2,4-dinitrobenzene increases expressionISOFTL (Homo sapiens)6480464Dinitrochlorobenzene results in increased expression of FTL mRNACTDPMID:20566472
Ftl1Rat17beta-estradiol affects expressionISOFTL (Homo sapiens)6480464Estradiol affects the expression of FTL mRNACTDPMID:22574217
Ftl1Rat17beta-estradiol decreases expressionISOFtl1 (Mus musculus)6480464Estradiol results in decreased expression of FTL1 mRNACTDPMID:39298647
Ftl1Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of FTL1 proteinCTDPMID:32145629
Ftl1Rat17beta-estradiol multiple interactionsISOFTL (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of FTL mRNACTDPMID:30165855
Ftl1Rat2,2',4,4',5,5'-hexachlorobiphenyl decreases expressionISOFTL (Homo sapiens)64804642 more ...CTDPMID:25686467
Ftl1Rat2,2',4,4',5,5'-hexachlorobiphenyl increases expressionISOFTL (Homo sapiens)64804642 more ...CTDPMID:38568856
Ftl1Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642 more ...CTDPMID:21394737
Ftl1Rat2,2',4,4'-Tetrabromodiphenyl ether multiple interactionsISOFtl1 (Mus musculus)6480464[Flame Retardants results in increased abundance of 2 more ...CTDPMID:38995820
Ftl1Rat2,3',4,4',5-Pentachlorobiphenyl increases expressionISOFtl1 (Mus musculus)64804642 more ...CTDPMID:31388691
Ftl1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOFtl1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of FTL1 mRNACTDPMID:15034205
Ftl1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of FTL1 mRNACTDPMID:34747641
Ftl1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOFtl1 (Mus musculus)6480464Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to FTL1 gene]CTDPMID:28213091

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Biological Process

  
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Original Reference(s)
Ftl1Ratintracellular iron ion homeostasis  TAS 61589 RGD 
Ftl1Ratintracellular iron ion homeostasis involved_inIEAInterPro:IPR0015191600115GO_REF:0000002InterProGO_REF:0000002
Ftl1Ratintracellular iron ion homeostasis involved_inIEAUniProtKB-KW:KW-04091600115GO_REF:0000043UniProtGO_REF:0000043
Ftl1Ratiron ion transport involved_inIEAInterPro:IPR0015191600115GO_REF:0000002InterProGO_REF:0000002
Ftl1Ratresponse to lead ion  IEP 5509838 RGD 

Cellular Component
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Original Reference(s)
Ftl1Ratautolysosome located_inISOFTL (Homo sapiens)1624291 PMID:25327288RGDPMID:25327288
Ftl1Ratautolysosome located_inIEAUniProtKB-SubCell:SL-05351600115GO_REF:0000044UniProtGO_REF:0000044
Ftl1Ratautophagosome located_inIEAUniProtKB-SubCell:SL-00231600115GO_REF:0000044UniProtGO_REF:0000044
Ftl1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Ftl1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Ftl1Ratcytoplasm is_active_inIBAFB:FBgn0015221 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Ftl1Ratcytoplasmic vesicle located_inIEAUniProtKB-KW:KW-09681600115GO_REF:0000043UniProtGO_REF:0000043
Ftl1Ratferritin complex part_ofISSUniProtKB:P027921600115GO_REF:0000024UniProtGO_REF:0000024
Ftl1Ratferritin complex part_ofISOFTL (Homo sapiens)1624291 PMID:19923220 and PMID:20159981RGDPMID:19923220 and PMID:20159981
Ftl1Ratlysosome located_inIEAUniProtKB-KW:KW-04581600115GO_REF:0000043UniProtGO_REF:0000043
1 to 10 of 10 rows

Molecular Function
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1 to 9 of 9 rows

RGD Manual Annotations


  
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Original Reference(s)
Ftl1Ratiron storage pathway  ISOFtl1 (Mus musculus)11556277 RGD 
Ftl1Ratiron storage pathway  ISOFtl1 (Mus musculus)11554199 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Ftl1Ratporphyrin and chlorophyll metabolic pathway  IEA 6907045 KEGGrno:00860

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#
Reference Title
Reference Citation
1. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, etal., Arterioscler Thromb Vasc Biol 1999 Nov;19(11):2600-8.
2. Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene. Barbeito AG, etal., J Neurochem. 2009 May;109(4):1067-78. Epub 2009 Mar 30.
3. Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation. Chinnery PF, etal., Brain. 2007 Jan;130(Pt 1):110-9. Epub 2006 Dec 2.
4. Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease. Curtis AR, etal., Nat Genet. 2001 Aug;28(4):350-4.
5. Isolation of cDNA clones corresponding to genes differentially expressed in two colon-carcinoma cell lines differing by their tumorigenicity. Denis MG, etal., Int J Cancer 1992 Apr 1;50(6):930-6.
6. Clinical features and natural history of neuroferritinopathy caused by the 458dupA FTL mutation. Devos D, etal., Brain. 2009 Jun;132(Pt 6):e109. Epub 2008 Oct 14.
7. Ferritin expression in rat hepatocytes and Kupffer cells after lead nitrate treatment. Fan Y, etal., Toxicol Pathol. 2009;37(2):209-17.
8. Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration. Finazzi D and Arosio P, Arch Toxicol. 2014 Oct;88(10):1787-802. doi: 10.1007/s00204-014-1329-0. Epub 2014 Aug 15.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Hereditary hyperferritinemia-cataract syndrome caused by a 29-base pair deletion in the iron responsive element of ferritin L-subunit gene. Girelli D, etal., Blood. 1997 Sep 1;90(5):2084-8.
11. Using IL-2R/lymphocytes for predicting the clinical progression of patients with COVID-19. Hou H, etal., Clin Exp Immunol. 2020 Jul;201(1):76-84. doi: 10.1111/cei.13450. Epub 2020 May 15.
12. A novel ferritin light chain gene mutation in a Japanese family with neuroferritinopathy: description of clinical features and implications for genotype-phenotype correlations. Kubota A, etal., Mov Disord. 2009 Feb 15;24(3):441-5.
13. Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease. Lane DJ, etal., Biochim Biophys Acta. 2015 May;1853(5):1130-44. doi: 10.1016/j.bbamcr.2015.01.021. Epub 2015 Feb 4.
14. Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes. Leibold EA and Munro HN, J Biol Chem 1987 May 25;262(15):7335-41.
15. Conservation in rat liver of light and heavy subunit sequences of mammalian ferritin. Presence of unique octopeptide in the light subunit. Leibold EA, etal., J Biol Chem 1984 Apr 10;259(7):4327-34.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Hereditary Hyperferritinemia Cataract Syndrome: Clinical, Genetic, and Laboratory Findings in 5 Families. Nonnenmacher L, etal., Klin Padiatr. 2011 Oct 21.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. GOA pipeline RGD automated data pipeline
1 to 20 of 26 rows
PMID:12477932   PMID:15489334   PMID:16169070   PMID:16189514   PMID:16790936   PMID:18996141   PMID:19056867   PMID:19923220   PMID:19946888   PMID:20159981   PMID:22206666   PMID:22207220  
PMID:23376485   PMID:23533145   PMID:24693535   PMID:25327288   PMID:25416956   PMID:25502805   PMID:25910212   PMID:31515488   PMID:31674712   PMID:33255702   PMID:36446230  



Ftl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81105,072,858 - 105,074,705 (-)NCBIGRCr8
mRatBN7.2195,936,387 - 95,938,234 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1044,257,727 - 44,258,273 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl195,936,387 - 95,939,725 (-)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl261,543,323 - 61,578,556 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1101,321,817 - 101,323,664 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01109,794,493 - 109,796,340 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01103,084,890 - 103,086,737 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01101,448,190 - 101,450,034 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01102,527,136 - 102,528,980 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4195,929,248 - 95,931,092 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1196,007,368 - 96,009,121 (-)NCBI
Celera190,192,302 - 90,194,146 (-)NCBICelera
Cytogenetic Map1q22NCBI
FTL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381948,965,309 - 48,966,879 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1948,965,309 - 48,967,896 (+)EnsemblGRCh38hg38GRCh38
GRCh371949,468,566 - 49,470,136 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361954,160,378 - 54,161,948 (+)NCBINCBI36Build 36hg18NCBI36
Build 341954,160,377 - 54,161,947NCBI
Celera1946,335,916 - 46,337,486 (+)NCBICelera
Cytogenetic Map19q13.33NCBI
HuRef1945,845,481 - 45,847,051 (+)NCBIHuRef
CHM1_11949,470,772 - 49,472,342 (+)NCBICHM1_1
T2T-CHM13v2.01951,960,189 - 51,961,759 (+)NCBIT2T-CHM13v2.0
Ftl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39745,107,368 - 45,109,310 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl745,107,368 - 45,109,308 (-)EnsemblGRCm39 Ensembl
GRCm38745,457,944 - 45,459,886 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl745,457,944 - 45,459,884 (-)EnsemblGRCm38mm10GRCm38
MGSCv37752,713,314 - 52,715,256 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36745,325,990 - 45,327,877 (-)NCBIMGSCv36mm8
Celera740,913,993 - 40,915,936 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map729.32NCBI
Ftl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555591,691,722 - 1,693,381 (-)NCBIChiLan1.0ChiLan1.0
FTL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22055,069,027 - 55,071,900 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11956,996,423 - 56,998,031 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01945,966,431 - 45,968,015 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11954,788,853 - 54,790,466 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1954,788,854 - 54,790,465 (-)Ensemblpanpan1.1panPan2
FTL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11107,418,457 - 107,419,923 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1107,418,458 - 107,419,923 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1106,941,044 - 106,942,510 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01107,943,144 - 107,944,610 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1107,943,145 - 107,944,610 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11107,610,673 - 107,612,136 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01107,257,026 - 107,258,492 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01108,092,628 - 108,094,094 (-)NCBIUU_Cfam_GSD_1.0
Ftl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934921,358,130 - 21,359,683 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366642,976,314 - 2,977,877 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366642,976,325 - 2,977,878 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FTL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl654,231,172 - 54,232,750 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1654,231,121 - 54,232,756 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2650,095,907 - 50,097,543 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FTL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1642,196,682 - 42,198,575 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl642,196,538 - 42,199,614 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607322,081,812 - 22,099,843 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ftl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248325,046,208 - 5,047,828 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248325,046,207 - 5,047,828 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Ftl1
3 total Variants

1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)178479925123479925Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
2300324Fetw1Fetal weight QTL 112.10.005fetal growth trait (VT:0004201)fetal body weight (CMO:0002080)185424647100358001Rat

1 to 10 of 45 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
12 21 92 195 148 150 100 44 100 6 377 170 167 80 101 50


1 to 30 of 69 rows
RefSeq Transcripts NM_022500 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC128792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC086583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209694 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219685 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219930 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220123 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220651 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220884 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221898 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224243 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 69 rows

Ensembl Acc Id: ENSRNOT00000028315   ⟹   ENSRNOP00000028315
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,936,387 - 95,938,234 (-)Ensembl
Rnor_6.0 Ensembl1101,448,346 - 101,449,829 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000054440   ⟹   ENSRNOP00000082353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1044,257,727 - 44,258,273 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000115869   ⟹   ENSRNOP00000086074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl195,936,401 - 95,939,725 (-)Ensembl
RefSeq Acc Id: NM_022500   ⟹   NP_071945
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81105,072,858 - 105,074,705 (-)NCBI
mRatBN7.2195,936,387 - 95,938,234 (-)NCBI
Rnor_6.01101,448,190 - 101,450,034 (-)NCBI
Rnor_5.01102,527,136 - 102,528,980 (-)NCBI
RGSC_v3.4195,929,248 - 95,931,092 (-)RGD
Celera190,192,302 - 90,194,146 (-)RGD
Sequence:
1 to 11 of 11 rows
Protein RefSeqs NP_071945 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41152 (Get FASTA)   NCBI Sequence Viewer  
  AAA41154 (Get FASTA)   NCBI Sequence Viewer  
  AAA41155 (Get FASTA)   NCBI Sequence Viewer  
  AAB19110 (Get FASTA)   NCBI Sequence Viewer  
  AAH61525 (Get FASTA)   NCBI Sequence Viewer  
  AAH86583 (Get FASTA)   NCBI Sequence Viewer  
  AAH88756 (Get FASTA)   NCBI Sequence Viewer  
  EDM07351 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000028315
GenBank Protein P02793 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_071945   ⟸   NM_022500
- UniProtKB: Q6P7T1 (UniProtKB/Swiss-Prot),   P02793 (UniProtKB/Swiss-Prot),   A6JB33 (UniProtKB/TrEMBL),   A0A8I6GIG4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028315   ⟸   ENSRNOT00000028315
Ensembl Acc Id: ENSRNOP00000082353   ⟸   ENSRNOT00000054440
Ensembl Acc Id: ENSRNOP00000086074   ⟸   ENSRNOT00000115869
Ferritin-like diiron

Name Modeler Protein Id AA Range Protein Structure
AF-P02793-F1-model_v2 AlphaFold P02793 1-183 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 39 of 39 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-59683 BioCyc
Ensembl Genes ENSRNOG00000020843 Ensembl
  ENSRNOG00000064385 Ensembl, ENTREZGENE
  ENSRNOG00000065602 Ensembl
Ensembl Transcript ENSRNOT00000028315 ENTREZGENE
Gene3D-CATH 1.20.1260.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6921603 IMAGE-MGC_LOAD
  IMAGE:7307718 IMAGE-MGC_LOAD
  IMAGE:7307747 IMAGE-MGC_LOAD
InterPro Ferritin UniProtKB/Swiss-Prot
  Ferritin-like UniProtKB/Swiss-Prot
  Ferritin-like_diiron UniProtKB/Swiss-Prot
  Ferritin-like_SF UniProtKB/Swiss-Prot
  Ferritin_CS UniProtKB/Swiss-Prot
  Ferritin_DPS_dom UniProtKB/Swiss-Prot
KEGG Report rno:29292 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105275 IMAGE-MGC_LOAD
  MGC:105276 IMAGE-MGC_LOAD
  MGC:72644 IMAGE-MGC_LOAD
NCBI Gene 29292 ENTREZGENE
PANTHER FERRITIN LIGHT CHAIN UniProtKB/Swiss-Prot
  PTHR11431 UniProtKB/Swiss-Prot
Pfam Ferritin UniProtKB/Swiss-Prot
PhenoGen Ftl1 PhenoGen
PROSITE FERRITIN_1 UniProtKB/Swiss-Prot
  FERRITIN_2 UniProtKB/Swiss-Prot
  FERRITIN_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000020843 RatGTEx
  ENSRNOG00000064385 RatGTEx
  ENSRNOG00000065602 RatGTEx
Superfamily-SCOP SSF47240 UniProtKB/Swiss-Prot
TIGR TC216466
UniProt A0A8I6A2Z0_RAT UniProtKB/TrEMBL
  A0A8I6GIG4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QFK4_RAT UniProtKB/TrEMBL
  A6JB33 ENTREZGENE, UniProtKB/TrEMBL
  FRIL1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6P7T1 ENTREZGENE
UniProt Secondary Q6P7T1 UniProtKB/Swiss-Prot
1 to 39 of 39 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-12-02 Ftl1  ferritin light chain 1  Ftl  ferritin, light polypeptide  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-25 Ftl  ferritin, light polypeptide  Ftl1  ferritin light chain 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ftl1  ferritin light chain 1      Name updated 70584 APPROVED

Note Type Note Reference
gene_homology 82% amino acid identity to human spleen homolog 632730
gene_protein 182 amino acids 632730