Uchl1 (ubiquitin C-terminal hydrolase L1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Uchl1 (ubiquitin C-terminal hydrolase L1) Rattus norvegicus
Analyze
Symbol: Uchl1
Name: ubiquitin C-terminal hydrolase L1
RGD ID: 3928
Description: Predicted to enable several functions, including alpha-2A adrenergic receptor binding activity; peptidase activity; and ubiquitin protein ligase binding activity. Involved in ubiquitin-dependent protein catabolic process. Predicted to be located in several cellular components, including neuron projection terminus; neuronal cell body; and nucleoplasm. Predicted to be active in cytoplasm. Biomarker of retinal disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; hereditary spastic paraplegia 79A; and hereditary spastic paraplegia 79B. Orthologous to human UCHL1 (ubiquitin C-terminal hydrolase L1); PARTICIPATES IN Parkinson's disease pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: neuron cytoplasmic protein 9.5; PGP 9.5; PGP9.5; ubiquitin carboxy-terminal hydrolase L1; ubiquitin carboxyl-terminal esterase L1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; UCH-L1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81441,838,859 - 41,849,743 (-)NCBIGRCr8
mRatBN7.21441,485,031 - 41,495,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1441,831,048 - 41,841,616 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01443,131,128 - 43,141,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01441,611,942 - 41,622,510 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01443,133,224 - 43,143,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,928,247 - 42,938,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,114,392 - 44,124,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11444,116,782 - 44,127,338 (-)NCBI
Celera1440,639,549 - 40,650,302 (-)NCBICelera
Cytogenetic Map14p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1RatAlzheimer's disease  ISOUCHL1 (Homo sapiens)1580538 RGD 
Uchl1RatDeglutition Disorders  ISOUchl1 (Mus musculus)1302546DNA:deletionRGD 
Uchl1Ratneuroaxonal dystrophy  ISOUchl1 (Mus musculus)1302546DNA:deletionRGD 
Uchl1Ratretinal disease  IEP 5490154mRNA:decreased expression:retinaRGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Ratgenetic disease  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:17576681 more ...
Uchl1Rathereditary spastic paraplegia 79A  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic paraplegia 79A more ...ClinVarPMID:25741868 more ...
Uchl1Rathereditary spastic paraplegia 79B  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndromeClinVarPMID:10203348 more ...
Uchl1RatHyperglycinemia, Lactic Acidosis, and Seizures  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: HYPERGLYCINEMIA more ...ClinVarPMID:28492532
Uchl1RatParkinson's disease  ISOUCHL1 (Homo sapiens)8554872ClinVar Annotator: match by term: Parkinson Disease and DominantClinVarPMID:25741868 and PMID:28492532
Uchl1RatParkinson's Disease 5  ISOUCHL1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10203348 more ...
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1RatDiaphragmatic Hernia  ISOUCHL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18958481
Uchl1RatEsophageal Neoplasms  ISOUCHL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15930319
Uchl1RatGallbladder Neoplasms  ISOUCHL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16965602
Uchl1Rathepatocellular carcinoma  ISOUCHL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18666234
Uchl1Ratlung non-small cell carcinoma  ISOUCHL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17094902
Uchl1Ratperipheral nervous system disease  ISOUCHL1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16797537

1 to 20 of 222 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Rat(1->4)-beta-D-glucan multiple interactionsISOUchl1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of UCHL1 mRNACTDPMID:36331819
Uchl1Rat(S)-nicotine multiple interactionsISOUchl1 (Mus musculus)6480464[Nicotine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Uchl1Rat1,2-dimethylhydrazine increases expressionISOUchl1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of UCHL1 mRNACTDPMID:22206623
Uchl1Rat1,2-naphthoquinone multiple interactionsISOUCHL1 (Homo sapiens)64804641 more ...CTDPMID:24582816
Uchl1Rat1,3-dinitrobenzene affects expressionEXP 64804643-dinitrobenzene affects the expression of UCHL1 mRNACTDPMID:16988215
Uchl1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOUchl1 (Mus musculus)6480464[Caffeine co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:20230807
Uchl1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases expressionISOUchl1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:15329391 more ...
Uchl1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine decreases response to substanceISOUchl1 (Mus musculus)6480464UCHL1 protein results in decreased susceptibility to 1-Methyl-4-phenyl-1 more ...CTDPMID:23643664
Uchl1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine increases expressionISOUchl1 (Mus musculus)64804641-Methyl-4-phenyl-1 more ...CTDPMID:22342763
Uchl1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of UCHL1 mRNACTDPMID:30723492
Uchl1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of UCHL1 mRNACTDPMID:12075121
Uchl1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of UCHL1 mRNACTDPMID:22298810
Uchl1Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of UCHL1 mRNACTDPMID:34747641
Uchl1Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOUchl1 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of UCHL1 mRNACTDPMID:24680724
Uchl1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionEXP 64804642 more ...CTDPMID:19954255
Uchl1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether decreases expressionISOUchl1 (Mus musculus)64804642 more ...CTDPMID:18550172
Uchl1Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether increases expressionEXP 64804642 more ...CTDPMID:19954255
Uchl1Rat2-methoxyethanol increases expressionEXP 6480464methyl cellosolve results in increased expression of UCHL1 proteinCTDPMID:15928459
Uchl1Rat4-hydroxynon-2-enal increases expressionISOUchl1 (Mus musculus)64804644-hydroxy-2-nonenal results in increased expression of UCHL1 mRNACTDPMID:19191707
Uchl1Rat4-methylcatechol multiple interactionsISOUchl1 (Mus musculus)64804644-methylcatechol inhibits the reaction [resiniferatoxin results in decreased expression of UCHL1 protein]CTDPMID:18219259

1 to 20 of 222 rows

Biological Process
1 to 20 of 31 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Ratadult walking behavior acts_upstream_of_or_withinIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratadult walking behavior acts_upstream_of_or_withinISOUchl1 (Mus musculus)1624291MGI:1355274 more ...RGDPMID:11555633 and PMID:3340629
Uchl1Rataxon target recognition acts_upstream_of_or_withinISOUchl1 (Mus musculus)1624291MGI:1856882 PMID:8474599RGDPMID:8474599
Uchl1Rataxon target recognition acts_upstream_of_or_withinIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Rataxonal transport of mitochondrion acts_upstream_of_or_withinISOUchl1 (Mus musculus)1624291MGI:1856882 PMID:2558488RGDPMID:2558488
Uchl1Rataxonal transport of mitochondrion acts_upstream_of_or_withinIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Rataxonogenesis acts_upstream_of_or_withinIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Rataxonogenesis acts_upstream_of_or_withinISOUchl1 (Mus musculus)1624291MGI:1856882 PMID:1630580RGDPMID:1630580
Uchl1Ratcellular response to xenobiotic stimulus involved_inIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcellular response to xenobiotic stimulus involved_inISOUchl1 (Mus musculus)1624291 PMID:23064229RGDPMID:23064229
Uchl1Rateating behavior acts_upstream_of_or_withinIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Rateating behavior acts_upstream_of_or_withinISOUchl1 (Mus musculus)1624291MGI:1355274 PMID:11555633RGDPMID:11555633
Uchl1Ratmale germ cell proliferation acts_upstream_of_or_withinIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratmale germ cell proliferation acts_upstream_of_or_withinISOUchl1 (Mus musculus)1624291MGI:1856882 PMID:12638230RGDPMID:12638230
Uchl1Ratmuscle cell development acts_upstream_of_or_withinISOUchl1 (Mus musculus)1624291MGI:94909 PMID:8007658RGDPMID:8007658
Uchl1Ratmuscle cell development acts_upstream_of_or_withinIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratnegative regulation of MAPK cascade involved_inISOUCHL1 (Homo sapiens)1624291 PMID:19477270RGDPMID:19477270
Uchl1Ratneuromuscular process acts_upstream_of_or_withinIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratneuromuscular process acts_upstream_of_or_withinISOUchl1 (Mus musculus)1624291MGI:1856882 PMID:3340629 and PMID:7555927RGDPMID:3340629 and PMID:7555927
Uchl1Ratpositive regulation of glycolytic process involved_inISOUCHL1 (Homo sapiens)1624291 PMID:34244144RGDPMID:34244144
1 to 20 of 31 rows

Cellular Component
1 to 20 of 27 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Rataxon located_inISOUchl1 (Mus musculus)1624291 PMID:11466438 more ...RGDPMID:11466438 more ...
Uchl1Rataxon located_inIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Rataxon cytoplasm located_inIEAGO:00198961600115GO_REF:0000108GOCGO_REF:0000108
Uchl1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Uchl1Ratcytoplasm located_inIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Uchl1Ratcytoplasm is_active_inIBAMGI:103149 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Uchl1Ratcytoplasm located_inIEAUniProtKB:P09936 and ensembl:ENSP000002844401600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcytoplasm located_inISOUCHL1 (Homo sapiens)1624291 PMID:19477270RGDPMID:19477270
Uchl1Ratcytoplasm located_inISOUchl1 (Mus musculus)1624291 PMID:12913066RGDPMID:12913066
Uchl1Ratcytosol located_inISOUCHL1 (Homo sapiens)1624291 RGDGO_REF:0000052
Uchl1Ratcytosol located_inIEAUniProtKB:P09936 and ensembl:ENSP000002844401600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcytosol located_inIEAUniProtKB:V9HW74 and ensembl:ENSP000002844401600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcytosol located_inIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcytosol located_inISOUchl1 (Mus musculus)1624291 PMID:12913066RGDPMID:12913066
Uchl1Ratendoplasmic reticulum located_inIEAUniProtKB-KW:KW-02561600115GO_REF:0000043UniProtGO_REF:0000043
Uchl1Ratendoplasmic reticulum membrane located_inIEAUniProtKB-SubCell:SL-00971600115GO_REF:0000044UniProtGO_REF:0000044
Uchl1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Uchl1Ratneuron projection terminus located_inISOUchl1 (Mus musculus)1624291 PMID:24760869RGDPMID:24760869
Uchl1Ratneuron projection terminus located_inIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 27 rows

Molecular Function
1 to 20 of 26 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1Ratalpha-2A adrenergic receptor binding enablesISOUCHL1 (Homo sapiens)1624291UniProtKB:P08913 and PMID:19477270RGDPMID:19477270
Uchl1Ratalpha-2A adrenergic receptor binding enablesIEAUniProtKB:P09936 and ensembl:ENSP000002844401600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcysteine-type deubiquitinase activity enablesIEAInterPro:IPR001578 and InterPro:IPR0369591600115GO_REF:0000002InterProGO_REF:0000002
Uchl1Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:P09936 and ensembl:ENSP000002844401600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcysteine-type deubiquitinase activity enablesISOUchl1 (Mus musculus)1624291 PMID:12913066RGDPMID:12913066
Uchl1Ratcysteine-type deubiquitinase activity enablesISOUCHL1 (Homo sapiens)1624291 PMID:34244144 and PMID:9521656RGDPMID:34244144 and PMID:9521656
Uchl1Ratcysteine-type deubiquitinase activity enablesIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcysteine-type deubiquitinase activity enablesIBAFB:FBgn0010288 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Uchl1Ratcysteine-type deubiquitinase activity enablesIEAEC:3.4.19.121600115GO_REF:0000003UniProtGO_REF:0000003
Uchl1Ratcysteine-type endopeptidase activity enablesISOUCHL1 (Homo sapiens)1624291 PMID:8639624RGDPMID:8639624
Uchl1Ratcysteine-type endopeptidase activity enablesIEAUniProtKB:P09936 and ensembl:ENSP000002844401600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratcysteine-type peptidase activity enablesIEAUniProtKB-KW:KW-07881600115GO_REF:0000043UniProtGO_REF:0000043
Uchl1Rathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
Uchl1Ratomega peptidase activity enablesISOUCHL1 (Homo sapiens)1624291 PMID:9521656RGDPMID:9521656
Uchl1Ratomega peptidase activity enablesIEAUniProtKB:P09936 and ensembl:ENSP000002844401600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
Uchl1Ratprotein binding enablesISOUCHL1 (Homo sapiens)1624291UniProtKB:A4FUJ8 more ...RGDPMID:12082530 more ...
Uchl1Ratribosome binding enablesISOUchl1 (Mus musculus)1624291 PMID:23064229RGDPMID:23064229
Uchl1Ratribosome binding enablesIEAUniProtKB:Q9R0P9 and ensembl:ENSMUSP000000311311600115GO_REF:0000107EnsemblGO_REF:0000107
Uchl1Ratsignaling receptor inhibitor activity enablesISOUCHL1 (Homo sapiens)1624291 PMID:19477270RGDPMID:19477270
1 to 20 of 26 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Uchl1RatParkinson's disease pathway   IEArno:050206907045 KEGGrno:05012

1 to 20 of 20 rows
#
Reference Title
Reference Citation
1. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. Choi J, etal., J Biol Chem. 2004 Mar 26;279(13):13256-64. Epub 2004 Jan 13.
2. The ubiquitin proteasome system in neurodegenerative diseases: sometimes the chicken, sometimes the egg. Ciechanover A and Brundin P, Neuron 2003 Oct 9;40(2):427-46.
3. Changes in ocular aquaporin-4 (AQP4) expression following retinal injury. Dibas A, etal., Mol Vis. 2008 Sep 25;14:1770-83.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Patient education: how we designed our own program. Hoffman LE Jr Group Pract 1976 Sep-Oct;25(5):21-4.
7. cDNA cloning and tissue distribution of a rat ubiquitin carboxyl-terminal hydrolase PGP9.5. Kajimoto Y, etal., J Biochem (Tokyo) 1992 Jul;112(1):28-32.
8. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
9. Loss of Uch-L1 and Uch-L3 leads to neurodegeneration, posterior paralysis and dysphagia. Kurihara LJ, etal., Hum Mol Genet 2001 Sep 1;10(18):1963-70.
10. The ubiquitin pathway in Parkinson's disease. Leroy E, etal., Nature 1998 Oct 1;395(6701):451-2.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. A role of the ubiquitin-proteasome system in neuropathic pain. Moss A, etal., J Neurosci 2002 Feb 15;22(4):1363-72.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. GOA pipeline RGD automated data pipeline
17. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
18. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
19. Intragenic deletion in the gene encoding ubiquitin carboxy-terminal hydrolase in gad mice. Saigoh K, etal., Nat Genet 1999 Sep;23(1):47-51.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 20 of 20 rows
PMID:1630580   PMID:2558488   PMID:3340629   PMID:7555927   PMID:8007658   PMID:8474599   PMID:8639624   PMID:8896700   PMID:9521656   PMID:11466438   PMID:11549719   PMID:11739622  
PMID:12074562   PMID:12107488   PMID:12408865   PMID:12477932   PMID:12638230   PMID:12866128   PMID:12913066   PMID:14695319   PMID:14973275   PMID:15489334   PMID:17011532   PMID:17599367  
PMID:17634366   PMID:17690318   PMID:18616865   PMID:19267071   PMID:19477270   PMID:19725078   PMID:20231490   PMID:20387083   PMID:20933087   PMID:21069350   PMID:21606356   PMID:22871113  
PMID:22926577   PMID:23064229   PMID:23284756   PMID:23376485   PMID:23599427   PMID:24090154   PMID:24625528   PMID:24760869   PMID:25326379   PMID:25638021   PMID:25763798   PMID:28500221  
PMID:29339092   PMID:29964011   PMID:30305579   PMID:30551363   PMID:31041655   PMID:34130526   PMID:36952018   PMID:38727276  



Uchl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81441,838,859 - 41,849,743 (-)NCBIGRCr8
mRatBN7.21441,485,031 - 41,495,590 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1441,831,048 - 41,841,616 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01443,131,128 - 43,141,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01441,611,942 - 41,622,510 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01443,133,224 - 43,143,942 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01442,928,247 - 42,938,981 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41444,114,392 - 44,124,947 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11444,116,782 - 44,127,338 (-)NCBI
Celera1440,639,549 - 40,650,302 (-)NCBICelera
Cytogenetic Map14p11NCBI
UCHL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38441,256,928 - 41,268,455 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl441,256,413 - 41,268,455 (+)EnsemblGRCh38hg38GRCh38
GRCh37441,258,945 - 41,270,472 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36440,953,686 - 40,965,203 (+)NCBINCBI36Build 36hg18NCBI36
Build 34441,099,856 - 41,111,373NCBI
Celera441,702,199 - 41,713,746 (+)NCBICelera
Cytogenetic Map4p13NCBI
HuRef440,580,844 - 40,592,391 (+)NCBIHuRef
CHM1_1441,259,044 - 41,270,591 (+)NCBICHM1_1
T2T-CHM13v2.0441,230,716 - 41,242,242 (+)NCBIT2T-CHM13v2.0
Uchl1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39566,833,464 - 66,844,577 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl566,833,434 - 66,844,577 (+)EnsemblGRCm39 Ensembl
GRCm38566,676,121 - 66,687,234 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl566,676,091 - 66,687,234 (+)EnsemblGRCm38mm10GRCm38
MGSCv37567,067,360 - 67,078,473 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36566,955,425 - 66,966,369 (+)NCBIMGSCv36mm8
Celera563,976,841 - 63,987,914 (+)NCBICelera
Cytogenetic Map5C3.1NCBI
cM Map535.95NCBI
Uchl1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554436,367,460 - 6,380,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554436,367,519 - 6,379,638 (-)NCBIChiLan1.0ChiLan1.0
UCHL1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2341,440,064 - 41,451,601 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1441,633,489 - 41,645,029 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0435,580,755 - 35,592,314 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1441,432,367 - 41,440,129 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl441,428,759 - 41,440,129 (+)Ensemblpanpan1.1panPan2
UCHL1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,396,694 - 71,430,395 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,370,822 - 71,411,350 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha373,946,978 - 73,961,370 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0372,157,557 - 72,171,966 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1371,427,585 - 71,441,983 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,589,640 - 71,604,050 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,972,745 - 71,987,146 (-)NCBIUU_Cfam_GSD_1.0
Uchl1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528537,734,649 - 37,746,530 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364828,551,603 - 8,563,651 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364828,551,749 - 8,563,586 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UCHL1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl832,353,246 - 32,367,332 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1832,353,766 - 32,367,288 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2833,970,620 - 33,982,399 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UCHL1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1279,074,961 - 9,086,606 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl279,074,923 - 9,086,517 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604755,406,774 - 55,418,174 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Uchl1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476125,784,257 - 25,797,549 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476125,786,028 - 25,797,641 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Uchl1
70 total Variants

Predicted Target Of
Summary Value
Count of predictions:70
Count of miRNA genes:57
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000003248
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 19 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
1358296Ael3Aortic elastin QTL 33.70.00051aorta elastin amount (VT:0003905)aortic elastin14826709053267090Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)141759376142336881Rat
61420Pia6Pristane induced arthritis QTL 64.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)141863134542337007Rat

1 to 10 of 19 rows
RH128109  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,485,066 - 41,485,252 (+)MAPPERmRatBN7.2
Rnor_6.01443,133,258 - 43,133,443NCBIRnor6.0
Rnor_5.01442,928,281 - 42,928,466UniSTSRnor5.0
RGSC_v3.41444,114,426 - 44,114,611UniSTSRGSC3.4
Celera1440,639,583 - 40,639,768UniSTS
Cytogenetic Map14p11UniSTS
BF399140  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21441,492,213 - 41,492,422 (+)MAPPERmRatBN7.2
Rnor_6.01443,140,568 - 43,140,776NCBIRnor6.0
Rnor_5.01442,935,591 - 42,935,799UniSTSRnor5.0
RGSC_v3.41444,121,573 - 44,121,781UniSTSRGSC3.4
Celera1440,646,926 - 40,647,134UniSTS
Cytogenetic Map14p11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 85 84 53 25 53 6 212 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000003248   ⟹   ENSRNOP00000003248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)Ensembl
Rnor_6.0 Ensembl1443,133,218 - 43,143,973 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094226   ⟹   ENSRNOP00000086461
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106879   ⟹   ENSRNOP00000082700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1441,485,031 - 41,495,590 (-)Ensembl
RefSeq Acc Id: NM_017237   ⟹   NP_058933
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81441,838,859 - 41,849,417 (-)NCBI
mRatBN7.21441,485,031 - 41,495,590 (-)NCBI
Rnor_6.01443,133,224 - 43,143,942 (-)NCBI
Rnor_5.01442,928,247 - 42,938,981 (-)NCBI
RGSC_v3.41444,114,392 - 44,124,947 (-)RGD
Celera1440,639,549 - 40,650,302 (-)RGD
Sequence:
RefSeq Acc Id: XM_063273003   ⟹   XP_063129073
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81441,839,356 - 41,849,493 (-)NCBI
RefSeq Acc Id: XM_063273004   ⟹   XP_063129074
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81441,838,859 - 41,849,743 (-)NCBI
RefSeq Acc Id: NP_058933   ⟸   NM_017237
- UniProtKB: Q6P9V8 (UniProtKB/Swiss-Prot),   Q00981 (UniProtKB/Swiss-Prot),   A6JDB6 (UniProtKB/TrEMBL),   A0A8L2Q0S4 (UniProtKB/TrEMBL),   A6JDB5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003248   ⟸   ENSRNOT00000003248
Ensembl Acc Id: ENSRNOP00000086461   ⟸   ENSRNOT00000094226
Ensembl Acc Id: ENSRNOP00000082700   ⟸   ENSRNOT00000106879
RefSeq Acc Id: XP_063129074   ⟸   XM_063273004
- Peptide Label: isoform X2
- UniProtKB: A0A8I6G7R6 (UniProtKB/TrEMBL),   A0A8L2Q0S4 (UniProtKB/TrEMBL),   A6JDB5 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-Q00981-F1-model_v2 AlphaFold Q00981 1-223 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699307
Promoter ID:EPDNEW_R9832
Type:multiple initiation site
Name:Uchl1_1
Description:ubiquitin C-terminal hydrolase L1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01443,143,942 - 43,144,002EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-15768 BioCyc
Ensembl Genes ENSRNOG00000002343 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003248 ENTREZGENE
  ENSRNOT00000094226.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.532.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920680 IMAGE-MGC_LOAD
InterPro Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Peptidase_C12_UCH UniProtKB/Swiss-Prot
  Peptidase_C12_UCH_sf UniProtKB/Swiss-Prot
KEGG Report rno:29545 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72862 IMAGE-MGC_LOAD
NCBI Gene 29545 ENTREZGENE
PANTHER PTHR10589 UniProtKB/Swiss-Prot
  PTHR10589:SF19 UniProtKB/Swiss-Prot
Pfam Peptidase_C12 UniProtKB/Swiss-Prot
PhenoGen Uchl1 PhenoGen
PRINTS UBCTHYDRLASE UniProtKB/Swiss-Prot
PROSITE UCH_1 UniProtKB/Swiss-Prot
  UCH_DOMAIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002343 RatGTEx
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
TIGR TC228392
UniProt A0A8I6G7R6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q0S4 ENTREZGENE, UniProtKB/TrEMBL
  A6JDB5 ENTREZGENE, UniProtKB/TrEMBL
  A6JDB6 ENTREZGENE, UniProtKB/TrEMBL
  A6JDB7_RAT UniProtKB/TrEMBL
  A6JDB8_RAT UniProtKB/TrEMBL
  Q00981 ENTREZGENE
  Q6P9V8 ENTREZGENE
  UCHL1_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q6P9V8 UniProtKB/Swiss-Prot
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-19 Uchl1  ubiquitin C-terminal hydrolase L1  Uchl1  ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-08-29 Uchl1  ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)  Uchl1  ubiquitin carboxy-terminal hydrolase L1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Uchl1  ubiquitin carboxy-terminal hydrolase L1      Name updated 70584 APPROVED