Tp53 (tumor protein p53) - Rat Genome Database

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Gene: Tp53 (tumor protein p53) Rattus norvegicus
Analyze
Symbol: Tp53
Name: tumor protein p53
RGD ID: 3889
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; transmembrane transporter binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to polyamine macromolecule; regulation of apoptotic process; and regulation of macromolecule biosynthetic process. Located in PML body and chromatin. Part of RNA polymerase II transcription regulator complex. Used to study disease of cellular proliferation (multiple); oral mucosa leukoplakia; and traumatic brain injury. Biomarker of several diseases, including bronchopulmonary dysplasia; gastrointestinal system cancer (multiple); ischemia; oral mucosa leukoplakia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; INTERACTS WITH (+)-catechin; (+)-dexrazoxane; (+)-schisandrin B.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cellular tumor antigen p53; MGC112612; p53; transformation related protein 53; Trp53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Tp53-ps1   Tp53-ps3  
Allele / Splice: Tp53em3Mcwi   Tp53m1Kyo   Tp53tm1(EGFP-Pac)Qly   Tp53em1Sage  
Genetic Models: SD-Tp53em3Mcwi SD-Tp53em1Sage STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc F344-Tp53m1Kyo
Is Marker For: Strains:   STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc   F344-Tp53m1Kyo  
Candidate Gene For: Hcar1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,798,871 - 54,810,300 (+)NCBIGRCr8
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,962,496 - 58,973,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,451,039 - 58,462,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,958,739 - 53,970,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Celera1053,454,375 - 53,465,803 (+)NCBICelera
Cytogenetic Map10q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Tp53Ratacute myeloid leukemia treatmentISOTP53 (Homo sapiens)11075071DNA:mutations: :RGD 
Tp53Ratacute myeloid leukemia disease_progressionISOTP53 (Homo sapiens)11057925 RGD 
Tp53Ratacute myeloid leukemia disease_progressionISOTP53 (Homo sapiens)11073714DNA:mutation: :RGD 
Tp53Ratadenoid cystic carcinoma disease_progressionISOTP53 (Homo sapiens)8547828 RGD 
Tp53RatAdrenal Cortex Neoplasms  ISOTP53 (Homo sapiens)14995484DNA:missense mutation::p.R337H (human)RGD 
Tp53RatAlzheimer's disease  ISOTrp53 (Mus musculus)2290573 RGD 
Tp53Ratangiosarcoma  ISOTrp53 (Mus musculus)151665099DNA:mutation:multiple (human)RGD 
Tp53Ratatherosclerosis amelioratesISOTrp53 (Mus musculus)242905202 RGD 
Tp53RatB-Cell Chronic Lymphocytic Leukemia disease_progressionISOTP53 (Homo sapiens)11075074DNA:deletion: :RGD 
Tp53RatB-lymphoblastic leukemia/lymphoma disease_progressionISOTP53 (Homo sapiens)11075072DNA:mutations: :RGD 
Tp53Ratbasal cell carcinoma  ISOTP53 (Homo sapiens)8547848 RGD 
Tp53Ratbasal cell carcinoma  ISOTP53 (Homo sapiens)8547844DNA:mutations:cds:RGD 
Tp53RatBone Marrow Neoplasms disease_progressionISOTP53 (Homo sapiens)11073734 RGD 
Tp53Ratbreast adenocarcinoma  ISOTrp53 (Mus musculus)2315939 RGD 
Tp53Ratbreast cancer  ISOTP53 (Homo sapiens)14995502DNA:missense mutation: :p.R72P (human)RGD 
Tp53RatBreast Neoplasms susceptibilityISOTP53 (Homo sapiens)2290534DNA:missense mutation: :p.R72PRGD 
Tp53RatBreast Neoplasms  ISOTP53 (Homo sapiens)2290531DNA:mutations:exonRGD 
Tp53Ratbronchiolo-alveolar adenocarcinoma  IMP 11075076DNA:mutations:exons:RGD 
Tp53Ratbronchopulmonary dysplasia  IEP 11537057 RGD 
Tp53Ratcataract  ISOTrp53 (Mus musculus)8547757 RGD 
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Tp53Ratacute megakaryocytic leukemia  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Acute megakaryocytic leukemiaClinVarPMID:11370630 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30720243 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30840781 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:30840781 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10089074 more ...
Tp53Ratacute myeloid leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:29025599 more ...
Tp53Ratadenocarcinoma  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: AdenocarcinomaClinVarPMID:10519380 more ...
Tp53Ratadenoid cystic carcinoma  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Adenocystic carcinomaClinVarPMID:10713666 more ...
Tp53Ratadrenocortical carcinoma  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10064694 more ...
Tp53Ratanaplastic astrocytoma  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Astrocytoma and anaplasticClinVarPMID:10519380 more ...
Tp53Ratanaplastic thyroid carcinoma  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Thyroid gland undifferentiated (anaplastic) carcinomaClinVarPMID:10864200 more ...
Tp53Ratatypical teratoid rhabdoid tumor  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Atypical teratoid/rhabdoid tumorClinVarPMID:10519380 more ...
Tp53RatAutosomal Recessive Dyskeratosis Congenita  ISOTP53 (Homo sapiens)8554872ClinVar Annotator: match by term: Dyskeratosis Congenita and RecessiveClinVarPMID:25741868 and PMID:28492532
Tp53Ratautosomal recessive dyskeratosis congenita 3  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17683073 more ...
Tp53RatB-Cell Chronic Lymphocytic Leukemia  ISOTP53 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10432928 more ...
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Tp53RatAcute Erythroleukemia  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:30926971
Tp53Ratacute kidney failure  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20603111
Tp53Ratacute lymphoblastic leukemia  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23334668
Tp53Ratacute myeloid leukemia  ISOTrp53 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25822087
Tp53Ratadenocarcinoma  ISOTP53 (Homo sapiens)11554173CTD more ...CTDPMID:10797276 more ...
Tp53Ratadenocarcinoma  ISOTrp53 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7955072 and PMID:16247444
Tp53Ratadenoid cystic carcinoma  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23685749
Tp53Ratadenoma  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21946351
Tp53RatAdrenal Gland Neoplasms  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24747643
Tp53Ratadrenocortical carcinoma  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9815696 more ...
Tp53Ratamyotrophic lateral sclerosis  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17434459
Tp53Ratangiosarcoma  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10626228
Tp53Ratangiosarcoma  ISOTrp53 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10930038 more ...
Tp53RatAnimal Disease Models  ISOTrp53 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23873029
Tp53RatArsenic Poisoning  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18621066 and PMID:19203779
Tp53RatB-Cell Chronic Lymphocytic Leukemia  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16439677
Tp53RatBalkan nephropathy  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22071594
Tp53Ratbasal cell carcinoma  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11511317 more ...
Tp53Ratbone development disease  ISOTrp53 (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9493073
Tp53Ratbrain ischemia  ISOTP53 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19095966
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Tp53Rat(+)-(S)-ar-turmerone increases expressionISOTP53 (Homo sapiens)6480464ar-turmerone results in increased expression of TP53 mRNA and ar-turmerone results in increased expression of TP53 proteinCTDPMID:19250610
Tp53Rat(+)-artemisinin increases activityISOTP53 (Homo sapiens)6480464artemisinin results in increased activity of TP53 proteinCTDPMID:30818834
Tp53Rat(+)-catechin multiple interactionsISOTrp53 (Mus musculus)6480464Catechin inhibits the reaction [tert-Butylhydroperoxide results in increased phosphorylation of TRP53 protein]CTDPMID:15879681
Tp53Rat(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [Rotenone results in increased expression of TP53 mRNA]CTDPMID:35337893
Tp53Rat(+)-catechin increases expressionISOTP53 (Homo sapiens)6480464Catechin results in increased expression of TP53 mRNA and Catechin results in increased expression of TP53 proteinCTDPMID:23706674
Tp53Rat(+)-dexrazoxane multiple interactionsISOTrp53 (Mus musculus)6480464Dexrazoxane inhibits the reaction [Idarubicin results in increased expression of TRP53 mRNA]CTDPMID:28973540
Tp53Rat(+)-dexrazoxane multiple interactionsEXP 6480464Dexrazoxane inhibits the reaction [Daunorubicin results in increased phosphorylation of TP53 protein]CTDPMID:38290791
Tp53Rat(+)-epicatechin-3-O-gallate multiple interactionsISOTrp53 (Mus musculus)6480464epicatechin gallate promotes the reaction [Benzo(a)pyrene results in increased expression of TRP53 mRNA]CTDPMID:18656336
Tp53Rat(+)-schisandrin B multiple interactionsISOTrp53 (Mus musculus)6480464[schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Aphidicolin results in increased phosphorylation of TRP53 protein] and [schizandrin B results in decreased activity of ATR protein] inhibits the reaction [Cisplatin results in increased phosphorylation of TRP53 protein]CTDPMID:22003191
Tp53Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of TP53 mRNA]CTDPMID:31150632
Tp53Rat(-)-alpha-phellandrene decreases expressionISOTrp53 (Mus musculus)6480464alpha phellandrene results in decreased expression of TRP53 proteinCTDPMID:24861204
Tp53Rat(-)-alpha-phellandrene increases expressionISOTrp53 (Mus musculus)6480464alpha phellandrene results in increased expression of TRP53 protein modified formCTDPMID:24861204
Tp53Rat(-)-alpha-phellandrene increases phosphorylationISOTrp53 (Mus musculus)6480464alpha phellandrene results in increased phosphorylation of TRP53 proteinCTDPMID:24861204
Tp53Rat(-)-alpha-phellandrene affects localizationISOTP53 (Homo sapiens)6480464alpha phellandrene affects the localization of TP53 proteinCTDPMID:25649747
Tp53Rat(-)-anisomycin multiple interactionsEXP 6480464Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein]CTDPMID:28842171
Tp53Rat(-)-citrinin increases expressionISOTP53 (Homo sapiens)6480464Citrinin results in increased expression of TP53 proteinCTDPMID:20929984
Tp53Rat(-)-citrinin increases expressionEXP 6480464Citrinin results in increased expression of TP53 protein modified formCTDPMID:22564900
Tp53Rat(-)-citrinin increases expressionISOTrp53 (Mus musculus)6480464Citrinin results in increased expression of TRP53 proteinCTDPMID:21622943
Tp53Rat(-)-epigallocatechin 3-gallate multiple interactionsISOTP53 (Homo sapiens)6480464epigallocatechin gallate affects the reaction [Doxorubicin affects the expression of TP53 protein] more ...CTDPMID:15657356 more ...
Tp53Rat(-)-epigallocatechin 3-gallate increases expressionISOTP53 (Homo sapiens)6480464epigallocatechin gallate results in increased expression of TP53 protein and epigallocatechin gallate results in increased expression of TP53 protein modified formCTDPMID:26341291 and PMID:32512070

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Biological Process
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Tp53Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Tp53Ratapoptotic process acts_upstream_ofISOTrp53 (Mus musculus)1624291MGI:1857989 PMID:17912366RGDPMID:17912366
Tp53Ratapoptotic process acts_upstream_of_or_withinIEAUniProtKB:P02340 and ensembl:ENSMUSP000001042981600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratapoptotic process involved_inISOTrp53 (Mus musculus)1624291 PMID:17434459RGDPMID:17434459
Tp53Ratapoptotic process acts_upstream_of_or_withinISOTrp53 (Mus musculus)1624291MGI:1343101 PMID:16183742 and PMID:17325035RGDPMID:16183742 and PMID:17325035
Tp53Ratapoptotic process involved_inIEAInterPro:IPR0021171600115GO_REF:0000002InterProGO_REF:0000002
Tp53Ratapoptotic signaling pathway involved_inIMP 10047225PMID:17998337UniProt 
Tp53Ratautophagy involved_inISOTP53 (Homo sapiens)1624291 PMID:23629966RGDPMID:23629966
Tp53Ratautophagy involved_inIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53RatB cell lineage commitment acts_upstream_of_or_withinIEAUniProtKB:P02340 and ensembl:ENSMUSP000001042981600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53RatB cell lineage commitment acts_upstream_of_or_withinISOTrp53 (Mus musculus)1624291MGI:1857590 PMID:8788039RGDPMID:8788039
Tp53Ratbone marrow development involved_inIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratbone marrow development involved_inISOTP53 (Homo sapiens)1624291 PMID:30146126RGDPMID:30146126
Tp53Ratcardiac muscle cell apoptotic process acts_upstream_ofISOTrp53 (Mus musculus)1624291MGI:1857263 PMID:22044588RGDPMID:22044588
Tp53Ratcardiac muscle cell apoptotic process acts_upstream_ofIEAUniProtKB:P02340 and ensembl:ENSMUSP000001042981600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcardiac septum morphogenesis acts_upstream_of_or_withinISOTrp53 (Mus musculus)1624291MGI:107934 more ...RGDPMID:22821713
Tp53Ratcardiac septum morphogenesis acts_upstream_of_or_withinIEAUniProtKB:P02340 and ensembl:ENSMUSP000001042981600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcell population proliferation acts_upstream_ofISOTrp53 (Mus musculus)1624291MGI:97306 PMID:10973261RGDPMID:10973261
Tp53Ratcell population proliferation acts_upstream_ofIEAUniProtKB:P02340 and ensembl:ENSMUSP000001042981600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcellular response to actinomycin D involved_inIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Tp53Ratcentrosome located_inISSUniProtKB:P046371600115GO_REF:0000024UniProtGO_REF:0000024
Tp53Ratcentrosome located_inIEAUniProtKB-SubCell:SL-00481600115GO_REF:0000044UniProtGO_REF:0000044
Tp53Ratcentrosome located_inISOTP53 (Homo sapiens)1624291 PMID:28842590RGDPMID:28842590
Tp53Ratcentrosome located_inIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratchromatin  IDA 1643534 RGD 
Tp53Ratchromatin located_inISOTP53 (Homo sapiens)1624291 PMID:15710329 more ...RGDPMID:15710329 more ...
Tp53Ratchromatin located_inIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Tp53Ratcytoplasm located_inIEAUniProtKB:P02340 and ensembl:ENSMUSP000001042981600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcytoplasm located_inISOTrp53 (Mus musculus)1624291 PMID:11799106 more ...RGDPMID:11799106 more ...
Tp53Ratcytoplasm located_inISOTP53 (Homo sapiens)1624291 PMID:14744935 more ...RGDPMID:14744935 more ...
Tp53Ratcytoplasm located_inISOTP53 (Homo sapiens) more ...1624291 PMID:16131611RGDPMID:16131611
Tp53Ratcytoplasm located_inISOTP53 (Homo sapiens) and UniProtKB:P04637-41624291 PMID:15340061RGDPMID:15340061
Tp53Ratcytoplasm located_inISSUniProtKB:P046371600115GO_REF:0000024UniProtGO_REF:0000024
Tp53Ratcytoplasm located_inIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Tp53Ratcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Tp53Ratcytosol located_inIEAUniProtKB:P02340 and ensembl:ENSMUSP000001042981600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcytosol located_inISOTrp53 (Mus musculus)1624291 PMID:11799106RGDPMID:11799106
Tp53Ratcytosol located_inISOTP53 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
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Molecular Function
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Tp53Rat14-3-3 protein binding enablesISOTP53 (Homo sapiens)1624291 PMID:20206173RGDPMID:20206173
Tp53RatATP-dependent DNA/DNA annealing activity enablesISSUniProtKB:P046371600115GO_REF:0000024UniProtGO_REF:0000024
Tp53RatATP-dependent DNA/DNA annealing activity enablesIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53RatATP-dependent DNA/DNA annealing activity enablesISOTP53 (Homo sapiens)1624291 PMID:8183576RGDPMID:8183576
Tp53Ratchromatin binding enablesISOTP53 (Homo sapiens)1624291 PMID:16322561 and PMID:17599062RGDPMID:16322561 and PMID:17599062
Tp53Ratchromatin binding enablesIEAUniProtKB:P02340 and ensembl:ENSMUSP000001042981600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratchromatin binding enablesISOTrp53 (Mus musculus)1624291 PMID:15657445 more ...RGDPMID:15657445 more ...
Tp53Ratchromatin binding enablesIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcis-regulatory region sequence-specific DNA binding enablesISOTP53 (Homo sapiens)1624291 PMID:10329733RGDPMID:10329733
Tp53Ratcis-regulatory region sequence-specific DNA binding enablesIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcopper ion binding enablesIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcopper ion binding enablesISOTP53 (Homo sapiens)1624291 PMID:7824276RGDPMID:7824276
Tp53Ratcopper ion binding enablesISSUniProtKB:P046371600115GO_REF:0000024UniProtGO_REF:0000024
Tp53Ratcore promoter sequence-specific DNA binding enablesIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratcore promoter sequence-specific DNA binding enablesISOTP53 (Homo sapiens)1624291 PMID:23629966RGDPMID:23629966
Tp53Ratdisordered domain specific binding enablesIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53Ratdisordered domain specific binding enablesISOTP53 (Homo sapiens)1624291UniProtKB:Q16665 and PMID:15629713RGDPMID:15629713
Tp53RatDNA binding enablesISSUniProtKB:P046371600115GO_REF:0000024UniProtGO_REF:0000024
Tp53RatDNA binding enablesIEAUniProtKB:P04637 and ensembl:ENSP000002693051600115GO_REF:0000107EnsemblGO_REF:0000107
Tp53RatDNA binding enablesIEAInterPro:IPR002117 and InterPro:IPR0123461600115GO_REF:0000002InterProGO_REF:0000002
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Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)

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Notes
Source
Original Reference(s)
Tp53Ratamyotrophic lateral sclerosis pathway  IEA 6907045 KEGGrno:05014
Tp53Ratapoptotic cell death pathway  IEA 6907045 KEGGrno:04210
Tp53Ratbasal cell carcinoma pathway  IEA 6907045 KEGGrno:05217
Tp53Ratcell cycle pathway, mitotic  IEA 6907045 KEGGrno:04110
Tp53Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Tp53Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Tp53Ratcolorectal cancer pathway   IEA 6907045 KEGGrno:05210
Tp53Ratendometrial cancer pathway   IEA 6907045 KEGGrno:05213
Tp53Ratglioma pathway  IEA 6907045 KEGGrno:05214
Tp53Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Tp53RatHuntington's disease pathway   IEA 6907045 KEGGrno:05016
Tp53Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Tp53Ratmelanoma pathway  IEA 6907045 KEGGrno:05218
Tp53Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
Tp53Ratneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722
Tp53Ratnon-small cell lung carcinoma pathway   IEA 6907045 KEGGrno:05223
Tp53Ratp53 signaling pathway   IEA 6907045 KEGGrno:04115
Tp53Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
Tp53Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215
Tp53Ratsmall cell lung carcinoma pathway  IEA 6907045 KEGGrno:05222
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Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tp53Ratp53 signaling pathway   ISOTP53 (Homo sapiens)6484113 PIDPID:200206
1 to 10 of 10 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Tp53Ratabnormal vacuole morphology  IMP 14995504seminiferous tubule and compared to SDRGD 
Tp53Ratdecreased body weight  IMP 14995504compared to SDRGD 
Tp53Ratdecreased testis weight  IMP 14995504 RGD 
Tp53Ratincreased cellular sensitivity to ionizing radiation  IMP 14995504compared to SDRGD 
Tp53Ratincreased male germ cell apoptosis  IMP 14995504 RGD 
Tp53Ratincreased tumor incidence  IMP 11075077 RGD 
Tp53Ratpremature death  IMP 12738450 RGD 
Tp53Ratseminiferous tubule degeneration  IMP 14995504compared to SDRGD 
Tp53Ratsmall epididymis  IMP 14995504compared to SDRGD 
Tp53Ratsmall seminiferous tubules  IMP 14995504compared to SDRGD 
1 to 10 of 10 rows

1 to 20 of 208 rows
#
Reference Title
Reference Citation
1. P21-dependent protective effects of a carbon monoxide-releasing molecule-3 in pulmonary hypertension. Abid S, etal., Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):304-12. doi: 10.1161/ATVBAHA.113.302302. Epub 2013 Dec 12.
2. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. Akulevich NM, etal., Endocr Relat Cancer. 2009 Jun;16(2):491-503. doi: 10.1677/ERC-08-0336. Epub 2009 Mar 13.
3. Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. Alam M and Mishra R, Life Sci. 2021 Sep 1;280:119705. doi: 10.1016/j.lfs.2021.119705. Epub 2021 Jun 8.
4. Expression of p53 protein in human middle ear cholesteatomas: pathogenetic implications. Albino AP, etal., Am J Otol. 1998 Jan;19(1):30-6.
5. The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer. Almquist LM, etal., Carcinogenesis. 2011 Mar;32(3):327-30. doi: 10.1093/carcin/bgq256. Epub 2010 Dec 1.
6. TP53 Gene Pro72Arg (rs1042522) Single Nucleotide Polymorphism as Not a Risk Factor for Colorectal Cancer in the Iranian Azari Population Asadi M, etal., Asian Pac J Cancer Prev. 2017 Dec 29;18(12):3423-3427. doi: 10.22034/APJCP.2017.18.12.3423.
7. p53 expression and apoptosis in the lens after ultraviolet radiation exposure. Ayala M, etal., Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4187-91.
8. Prognosis of adenocarcinoma of the uterine cervix: p53 expression correlates with higher incidence of mortality. Baalbergen A, etal., Int J Cancer. 2007 Jul 1;121(1):106-10.
9. Prognostic value of TP53 gene mutations in myelodysplastic syndromes and acute myeloid leukemia treated with azacitidine. Bally C, etal., Leuk Res. 2014 Jul;38(7):751-5. doi: 10.1016/j.leukres.2014.03.012. Epub 2014 Mar 23.
10. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
11. The mutational landscape of prostate cancer. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
12. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
13. Targeted-simultaneous expression of Gas1 and p53 using a bicistronic adenoviral vector in gliomas. Benitez JA, etal., Cancer Gene Ther. 2007 Oct;14(10):836-46. Epub 2007 Jun 29.
14. Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Bhanoori M, etal., Oncogene 2003 Jan 9;22(1):117-30.
15. The 5' region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element. Bienz-Tadmor B, etal., EMBO J 1985 Dec 1;4(12):3209-13.
16. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Bitar MS, etal., Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E951-63. doi: 10.1152/ajpendo.00189.2013. Epub 2013 Aug 13.
17. Expression of p53 in arsenic-related and sporadic basal cell carcinoma. Boonchai W, etal., Arch Dermatol. 2000 Feb;136(2):195-8.
18. Tp53 status as guide for the management of ethmoid sinus intestinal-type adenocarcinoma. Bossi P, etal., Oral Oncol. 2013 May;49(5):413-9. doi: 10.1016/j.oraloncology.2012.12.011. Epub 2013 Jan 29.
19. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. Budhram-Mahadeo V, etal., J Biol Chem. 1999 May 21;274(21):15237-44. doi: 10.1074/jbc.274.21.15237.
20. Genetic polymorphisms associated with cigarette smoking and the risk of Graves' disease. Bufalo NE, etal., Clin Endocrinol (Oxf). 2008 Jun;68(6):982-7. Epub 2007 Nov 2.
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1 to 10 of 44 rows
PMID:2144364   PMID:7587074   PMID:7663514   PMID:7677753   PMID:7720704   PMID:7824276   PMID:7958916   PMID:8058315   PMID:8183576   PMID:8183579   PMID:8612582   PMID:8663025  
PMID:8788039   PMID:8875929   PMID:8986812   PMID:9024662   PMID:9054499   PMID:9098922   PMID:9194565   PMID:9288110   PMID:9425892   PMID:9529249   PMID:9578398   PMID:9608530  
PMID:10065150   PMID:10205143   PMID:10360174   PMID:10415337   PMID:10518217   PMID:10562313   PMID:10567591   PMID:10591652   PMID:10591653   PMID:10597287   PMID:10666337   PMID:10710310  
PMID:10716720   PMID:10805805   PMID:10815637   PMID:10837489   PMID:10876243   PMID:10894779   PMID:10911993   PMID:10962037   PMID:10973261   PMID:11080164   PMID:11092819   PMID:11150333  
PMID:11246230   PMID:11546806   PMID:11672523   PMID:11748221   PMID:11781842   PMID:11790307   PMID:11799106   PMID:11861836   PMID:11884608   PMID:11900485   PMID:11923872   PMID:11958430  
PMID:11983168   PMID:12006491   PMID:12080348   PMID:12135983   PMID:12143041   PMID:12172011   PMID:12215673   PMID:12379483   PMID:12503078   PMID:12506145   PMID:12524542   PMID:12534344  
PMID:12538352   PMID:12549819   PMID:12654005   PMID:12667443   PMID:12730672   PMID:12835324   PMID:12837246   PMID:12850271   PMID:12869365   PMID:12878730   PMID:12915590   PMID:12952892  
PMID:14514686   PMID:14576152   PMID:14654789   PMID:14685795   PMID:14695767   PMID:14729462   PMID:14739302   PMID:14744935   PMID:14962081   PMID:14963330   PMID:14985081   PMID:15002037  
PMID:15033826   PMID:15044383   PMID:15053879   PMID:15122989   PMID:15149599   PMID:15199126   PMID:15219885   PMID:15314173   PMID:15315938   PMID:15340061   PMID:15358771   PMID:15364958  
PMID:15383658   PMID:15483136   PMID:15485914   PMID:15532030   PMID:15565177   PMID:15577914   PMID:15629713   PMID:15657445   PMID:15705871   PMID:15710329   PMID:15735665   PMID:15735701  
1 to 10 of 44 rows



Tp53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,798,871 - 54,810,300 (+)NCBIGRCr8
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1058,962,496 - 58,973,951 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,451,039 - 58,462,496 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,958,739 - 53,970,151 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Celera1053,454,375 - 53,465,803 (+)NCBICelera
Cytogenetic Map10q24NCBI
TP53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,668,421 - 7,687,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,661,779 - 7,687,546 (-)EnsemblGRCh38hg38GRCh38
GRCh37177,571,739 - 7,590,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,512,445 - 7,531,642 (-)NCBINCBI36Build 36hg18NCBI36
Build 34177,512,463 - 7,531,642NCBI
Celera177,598,099 - 7,617,224 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,465,169 - 7,484,283 (-)NCBIHuRef
CHM1_1177,580,866 - 7,600,003 (-)NCBICHM1_1
T2T-CHM13v2.0177,572,544 - 7,591,594 (-)NCBIT2T-CHM13v2.0
Trp53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,471,174 - 69,482,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,471,185 - 69,482,699 (+)EnsemblGRCm39 Ensembl
GRCm381169,580,348 - 69,591,873 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,580,359 - 69,591,873 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,393,861 - 69,405,375 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361169,396,176 - 69,408,066 (+)NCBIMGSCv36mm8
Celera1176,543,319 - 76,554,788 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.83NCBI
Tp53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,252,130 - 9,255,928 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,241,391 - 9,256,716 (+)NCBIChiLan1.0ChiLan1.0
TP53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,262,550 - 15,280,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,217,636 - 17,246,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,699,449 - 7,717,812 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,687,132 - 7,706,120 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,684,922 - 7,706,120 (-)Ensemblpanpan1.1panPan2
TP53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,561,406 - 32,565,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,560,598 - 32,574,109 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha532,699,559 - 32,713,071 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0532,665,395 - 32,678,721 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,665,394 - 32,678,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,633,092 - 32,646,601 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,589,339 - 32,602,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,768,467 - 32,781,775 (-)NCBIUU_Cfam_GSD_1.0
Tp53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,445,372 - 47,461,208 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595919,428 - 925,425 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936595919,807 - 935,367 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,939,644 - 52,953,818 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,939,643 - 52,953,786 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,220,545 - 55,234,668 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12q12-q14NCBI
TP53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,047,686 - 7,065,567 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,045,146 - 7,066,223 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605914,343,255 - 14,361,299 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,263,518 - 10,271,218 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478610,266,316 - 10,282,664 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Tp53
52 total Variants


Assembly: mRatBN7.2
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 54307283 54307284 C T snv SHRSP/A3NCrl (2019), SHRSP/A3NCrl (2019NG) View more Information
10 54308389 54308390 C A snv SHR/NHsd (2021), SHR/OlalpcvMcwi (2019NG), SHR/NCrl (2021), BXH6/CubMcwi (2021), WKY/N (2020), WKY/NCrl (2019), SHR/OlalpcvMcwi (2019), HXB4/IpcvMcwi (2020), HXB31/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB10/IpcvMcwi (2019), European Variation Archive Release 6, European Variation Archive Release 4, European Variation Archive Release 3 View more Information
10 54308474 54308475 A T snv European Variation Archive Release 3, HXB10/IpcvMcwi (2019), European Variation Archive Release 6, BXH3/CubMcwi (2020), WKY/NCrl (2019NG), SHR/OlalpcvMcwi (2019NG), SHR/NHsd (2021), SHR/NHsd (2021), SHR/NCrl (2021), BXH6/CubMcwi (2021), WKY/N (2020), WKY/NCrl (2019), SHR/OlalpcvMcwi (2019), HXB4/IpcvMcwi (2020), HXB31/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), European Variation Archive Release 4 View more Information
10 54308495 54308496 T C snv BXH3/CubMcwi (2020), HXB10/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB31/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), SHR/OlalpcvMcwi (2019), WKY/NCrl (2019), WKY/N (2020), BXH6/CubMcwi (2021), SHR/NCrl (2021), SHR/NHsd (2021), SHR/NHsd (2021), SHR/OlalpcvMcwi (2019NG), WKY/NCrl (2019NG) View more Information
10 54308503 54308504 C T snv SHR/OlalpcvMcwi (2019), WKY/NCrl (2019), WKY/N (2020), SHR/NCrl (2021), SHR/NHsd (2021), SHR/OlalpcvMcwi (2019NG), BXH6/CubMcwi (2021), SHR/NHsd (2021), BXH3/CubMcwi (2020), HXB10/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB31/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), WKY/NCrl (2019NG) View more Information
10 54308513 54308514 A G snv SHR/OlalpcvMcwi (2019NG), WKY/NCrl (2019NG), SHR/NHsd (2021), SHR/NHsd (2021), SHR/NCrl (2021), BXH6/CubMcwi (2021), WKY/N (2020), WKY/NCrl (2019), SHR/OlalpcvMcwi (2019), HXB4/IpcvMcwi (2020), HXB31/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB10/IpcvMcwi (2019), BXH3/CubMcwi (2020) View more Information
10 54308530 54308531 G A snv BXH3/CubMcwi (2020), HXB10/IpcvMcwi (2019), WKY/NCrl (2019NG), SHR/OlalpcvMcwi (2019NG), SHR/NHsd (2021), SHR/NHsd (2021), SHR/NCrl (2021), BXH6/CubMcwi (2021), WKY/N (2020), WKY/NCrl (2019), SHR/OlalpcvMcwi (2019), HXB4/IpcvMcwi (2020), HXB31/IpcvMcwi (2019), HXB2/IpcvMcwi (2019) View more Information
10 54311071 54311072 G A snv WKY/NCrl (2019NG), HXB10/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB31/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), SHR/OlalpcvMcwi (2019), BXH3/CubMcwi (2020), WKY/N (2020), BXH6/CubMcwi (2021), SHR/NCrl (2021), SHR/NHsd (2021), SHR/NHsd (2021), SHR/OlalpcvMcwi (2019NG), WKY/NCrl (2019) View more Information


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 56408014 56408015 C A snv WKY/N (KNAW) View more Information
10 56408099 56408100 A T snv LCR/2Mco (UMich) View more Information
10 56408138 56408139 A G snv LCR/2Mco (UMich) View more Information
10 56410696 56410697 G A snv LCR/2Mco (UMich), WKY/NCrl (ICL), WKY/Gcrc (ICL), WKY/NHsd (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), HCR/2Mco (UMich), SHR/OlaIpcv (ICL), WKY/N (KNAW), SHR/OlaIpcv (ICL), SHR/NHsd (ICL) View more Information


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 55939538 55939539 T A snv IS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU) View more Information
10 55940951 55940952 C A snv IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU) View more Information
10 55941036 55941037 A T snv IS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU) View more Information
10 55941057 55941058 T C snv IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU) View more Information
10 55941065 55941066 C T snv IS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU) View more Information
10 55941075 55941076 A G snv IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU) View more Information
10 55941092 55941093 G A snv IS/Kyo (KyushuU), IS-Tlk/Kyo (KyushuU) View more Information
10 55941242 55941243 G A snv IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU) View more Information
10 55941766 55941767 G A snv IS/Kyo (KyushuU) View more Information
10 55941782 55941783 C A snv IS/Kyo (KyushuU) View more Information
10 55941794 55941795 A T snv IS/Kyo (KyushuU) View more Information
10 55943633 55943634 G A snv IS-Tlk/Kyo (KyushuU), IS/Kyo (KyushuU) View more Information


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
10 56193900 56193901 T A snv HXB31/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), HXB2/IpcvMcwi (2019), BXH3/CubMcwi (2020), WKY/N (2020) View more Information
10 56194207 56194208 C T snv SHRSP/A3NCrl (2019) View more Information
10 56195313 56195314 C A snv HXB4/IpcvMcwi (2020), SHR/OlalpcvMcwi (2019), WKY/N (2020), HXB2/IpcvMcwi (2019), HXB31/IpcvMcwi (2019), HXB10/IpcvMcwi (2019), WKY/Gcrc (RGD), WKY/N (MCW), European Variation Archive Release 6, European Variation Archive Release 4, European Variation Archive Release 3 View more Information
10 56195398 56195399 A T snv WKY/N (2020), WKY/NCrl (2019), SHR/OlalpcvMcwi (2019), HXB4/IpcvMcwi (2020), SHR/NHsd (RGD), HXB2/IpcvMcwi (2019), HXB10/IpcvMcwi (2019), BXH3/CubMcwi (2020), HXB31/IpcvMcwi (2019) View more Information
10 56195419 56195420 T C snv WKY/NCrl (2019), WKY/N (2020), SHR/OlalpcvMcwi (2019), HXB4/IpcvMcwi (2020), HXB31/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB10/IpcvMcwi (2019), BXH3/CubMcwi (2020) View more Information
10 56195427 56195428 C T snv BXH3/CubMcwi (2020), HXB10/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB31/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), SHR/OlalpcvMcwi (2019), WKY/NCrl (2019), WKY/N (2020) View more Information
10 56195437 56195438 A G snv BXH3/CubMcwi (2020), HXB10/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB31/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), SHR/OlalpcvMcwi (2019), WKY/NCrl (2019), WKY/N (2020) View more Information
10 56195454 56195455 G A snv WKY/NCrl (2019), SHR/OlalpcvMcwi (2019), HXB4/IpcvMcwi (2020), HXB31/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB10/IpcvMcwi (2019), BXH3/CubMcwi (2020), WKY/N (2020) View more Information
10 56195604 56195605 G A snv WKY/NCrl (RGD), BXH3/CubMcwi (2020), HXB10/IpcvMcwi (2019), HXB2/IpcvMcwi (2019), HXB31/IpcvMcwi (2019), HXB4/IpcvMcwi (2020), SHR/OlalpcvMcwi (2019), WKY/N (2020), WKY/NCrl (2019) View more Information
10 56196128 56196129 G A snv HXB31/IpcvMcwi (2019) View more Information
10 56196138 56196139 G A snv HXB31/IpcvMcwi (2019) View more Information
10 56196144 56196145 C A snv HXB31/IpcvMcwi (2019) View more Information
10 56196156 56196157 A T snv HXB31/IpcvMcwi (2019) View more Information
10 56197995 56197996 G A snv HXB4/IpcvMcwi (2020), HXB2/IpcvMcwi (2019), HXB10/IpcvMcwi (2019), BXH3/CubMcwi (2020), WKY/N (MCW), SHR/OlalpcvMcwi (2019), WKY/NCrl (2019), WKY/N (2020), HXB31/IpcvMcwi (2019) View more Information

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir30arno-miR-30a-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI20062521

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:177
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000046490
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 76 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103571058068663659Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104698969968663659Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)104944455181709989Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105166340575085664Rat

1 to 10 of 76 rows
RH128204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,311,066 - 54,311,282 (+)MAPPERmRatBN7.2
Rnor_6.01056,197,991 - 56,198,206NCBIRnor6.0
Rnor_5.01055,943,629 - 55,943,844UniSTSRnor5.0
RGSC_v3.41056,410,692 - 56,410,907UniSTSRGSC3.4
Celera1053,465,345 - 53,465,560UniSTS
Cytogenetic Map10q24UniSTS
X00876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,311,363 - 54,311,441 (+)MAPPERmRatBN7.2
mRatBN7.21880,956,863 - 80,956,942 (+)MAPPERmRatBN7.2
Rnor_6.01884,790,380 - 84,790,458NCBIRnor6.0
Rnor_6.01056,198,288 - 56,198,365NCBIRnor6.0
Rnor_5.01883,848,025 - 83,848,103UniSTSRnor5.0
Rnor_5.01055,943,926 - 55,944,003UniSTSRnor5.0
RGSC_v3.41056,410,989 - 56,411,066UniSTSRGSC3.4
RGSC_v3.41884,480,395 - 84,480,473UniSTSRGSC3.4
Celera1879,535,283 - 79,535,361UniSTS
Celera1053,465,642 - 53,465,719UniSTS
Cytogenetic Map10q24UniSTS
GDB:190076  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81054,807,589 - 54,807,975 (+)Marker Load Pipeline
mRatBN7.21054,308,814 - 54,309,200 (+)MAPPERmRatBN7.2
Rnor_6.0249,382,697 - 49,382,771NCBIRnor6.0
Rnor_6.01056,195,739 - 56,196,124NCBIRnor6.0
Rnor_5.01055,941,377 - 55,941,762UniSTSRnor5.0
Rnor_5.0267,753,862 - 67,753,936UniSTSRnor5.0
RGSC_v3.41056,408,440 - 56,408,825UniSTSRGSC3.4
Celera1053,463,093 - 53,463,478UniSTS
Cytogenetic Map10q24UniSTS
PMC316663P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,308,611 - 54,308,724 (+)MAPPERmRatBN7.2
Rnor_6.01056,195,536 - 56,195,648NCBIRnor6.0
Rnor_5.01055,941,174 - 55,941,286UniSTSRnor5.0
RGSC_v3.41056,408,237 - 56,408,349UniSTSRGSC3.4
Celera1053,462,890 - 53,463,002UniSTS
Cytogenetic Map10q24UniSTS
PMC316856P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81054,807,224 - 54,807,389 (+)Marker Load Pipeline
mRatBN7.21054,308,448 - 54,308,614 (+)MAPPERmRatBN7.2
Rnor_6.01056,195,373 - 56,195,538NCBIRnor6.0
Rnor_5.01055,941,011 - 55,941,176UniSTSRnor5.0
RGSC_v3.41056,408,074 - 56,408,239UniSTSRGSC3.4
Celera1053,462,727 - 53,462,892UniSTS
Cytogenetic Map10q24UniSTS


The following Strains have been annotated to Tp53
F344-Tp53m1Kyo     STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc    


This gene Tp53 is modified in the following models/strains:
SD-Tp53em3Mcwi     SD-Tp53em1Sage     STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc     F344-Tp53m1Kyo    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 25 of 25 rows
RefSeq Transcripts NM_001429993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF190270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF209191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY009504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV126174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z93723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 25 of 25 rows

Ensembl Acc Id: ENSRNOT00000046490   ⟹   ENSRNOP00000047840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,300,052 - 54,311,521 (+)Ensembl
Rnor_6.0 Ensembl1056,187,020 - 56,198,448 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080584   ⟹   ENSRNOP00000068796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,306,942 - 54,309,573 (+)Ensembl
Rnor_6.0 Ensembl1056,193,856 - 56,198,031 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083458   ⟹   ENSRNOP00000075724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,300,052 - 54,310,666 (+)Ensembl
Rnor_6.0 Ensembl1056,193,866 - 56,198,000 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085115   ⟹   ENSRNOP00000074031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,300,753 - 54,311,523 (+)Ensembl
Rnor_6.0 Ensembl1056,187,679 - 56,198,449 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091216   ⟹   ENSRNOP00000075683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,306,942 - 54,311,524 (+)Ensembl
Rnor_6.0 Ensembl1056,193,866 - 56,198,000 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102405   ⟹   ENSRNOP00000080907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,300,048 - 54,311,519 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104927   ⟹   ENSRNOP00000092831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,305,746 - 54,311,524 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114382   ⟹   ENSRNOP00000089020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,305,746 - 54,310,954 (+)Ensembl
RefSeq Acc Id: NM_030989   ⟹   NP_112251
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,798,871 - 54,810,300 (+)NCBI
mRatBN7.21054,300,096 - 54,311,525 (+)NCBI
Rnor_6.01056,187,020 - 56,198,449 (+)NCBI
Rnor_5.01055,932,658 - 55,944,087 (+)NCBI
RGSC_v3.41056,399,721 - 56,411,150 (+)RGD
Celera1053,454,375 - 53,465,803 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767773   ⟹   XP_008765995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,798,933 - 54,810,300 (+)NCBI
mRatBN7.21054,300,070 - 54,311,023 (+)NCBI
Rnor_6.01056,186,299 - 56,197,912 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597018   ⟹   XP_017452507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,799,817 - 54,810,300 (+)NCBI
mRatBN7.21054,301,043 - 54,311,025 (+)NCBI
Rnor_6.01056,187,961 - 56,197,912 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268429   ⟹   XP_063124499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,805,369 - 54,810,300 (+)NCBI
RefSeq Acc Id: XM_063268430   ⟹   XP_063124500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,799,817 - 54,810,300 (+)NCBI
1 to 5 of 13 rows
1 to 5 of 13 rows
RefSeq Acc Id: NP_112251   ⟸   NM_030989
- UniProtKB: Q4KMA9 (UniProtKB/Swiss-Prot),   O09168 (UniProtKB/Swiss-Prot),   Q66HM0 (UniProtKB/Swiss-Prot),   P10361 (UniProtKB/Swiss-Prot),   A6HFR6 (UniProtKB/TrEMBL),   A0A8L2R913 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765995   ⟸   XM_008767773
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452507   ⟸   XM_017597018
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000068796   ⟸   ENSRNOT00000080584
Ensembl Acc Id: ENSRNOP00000074031   ⟸   ENSRNOT00000085115
p53 DNA-binding   p53 tetramerisation   p53 transactivation

Name Modeler Protein Id AA Range Protein Structure
AF-P10361-F1-model_v2 AlphaFold P10361 1-391 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697316
Promoter ID:EPDNEW_R7839
Type:initiation region
Name:Tp53_1
Description:tumor protein p53
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,187,031 - 56,187,091EPDNEW


1 to 40 of 51 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-24540 BioCyc
Ensembl Genes ENSRNOG00000010756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046490 ENTREZGENE
  ENSRNOT00000046490.4 UniProtKB/Swiss-Prot
  ENSRNOT00000085115 ENTREZGENE
  ENSRNOT00000102405 ENTREZGENE
Gene3D-CATH 2.60.40.720 UniProtKB/Swiss-Prot
  4.10.170.10 UniProtKB/Swiss-Prot
  6.10.50.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193583 IMAGE-MGC_LOAD
  IMAGE:7384467 IMAGE-MGC_LOAD
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/Swiss-Prot
  p53_DNA-bd UniProtKB/Swiss-Prot
  p53_tetramer_sf UniProtKB/Swiss-Prot
  p53_tetrameristn UniProtKB/Swiss-Prot
  p53_transactivation_domain UniProtKB/Swiss-Prot
  p53_tumour_suppressor UniProtKB/Swiss-Prot
KEGG Report rno:24842 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112612 IMAGE-MGC_LOAD
  MGC:93394 IMAGE-MGC_LOAD
NCBI Gene 24842 ENTREZGENE
PANTHER CELLULAR TUMOR ANTIGEN P53 UniProtKB/Swiss-Prot
  PTHR11447 UniProtKB/Swiss-Prot
Pfam P53 UniProtKB/Swiss-Prot
  P53_TAD UniProtKB/Swiss-Prot
  P53_tetramer UniProtKB/Swiss-Prot
PharmGKB TP53 RGD
PhenoGen Tp53 PhenoGen
PRINTS P53SUPPRESSR UniProtKB/Swiss-Prot
PROSITE P53 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010756 RatGTEx
Superfamily-SCOP SSF47719 UniProtKB/Swiss-Prot
  SSF49417 UniProtKB/Swiss-Prot
UniProt A0A0G2JTP9_RAT UniProtKB/TrEMBL
  A0A0G2KB75_RAT UniProtKB/TrEMBL
  A0A0G2KBB2_RAT UniProtKB/TrEMBL
  A0A8I5ZQW3_RAT UniProtKB/TrEMBL
  A0A8I6AAP4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AEF4_RAT UniProtKB/TrEMBL
1 to 40 of 51 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tp53  tumor protein p53  Trp53  transformation related protein 53  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Trp53  transformation related protein 53  Tp53  tumor protein p53   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tp53  tumor protein p53     tumor protein p53 (Li-Fraumeni syndrome)  Name updated 629478 APPROVED
2002-06-10 Tp53  tumor protein p53 (Li-Fraumeni syndrome)      Name updated 70584 APPROVED

Note Type Note Reference
gene_expression nuclear accumulation increased in estrogen- and progesterone-treated animals and in pregnant-involuted mammary glands 69666
gene_expression nuclear accumulation increased in estrogen- and progesterone-treated animals and in pregnant-involuted mammary glands 625510
gene_function transcription factor 70312
gene_mutations_overexpression mutations found in the DNA binding domain of the gene 625510
gene_process directly phosphorylates casein kinase I and II, double-stranded RNA-dependent protein kinase, c-Jun N-terminal kinase, and p38 MAP kinase 625510
gene_process maintains genome integrety 70312
gene_process maintains genome integrety 70313
gene_process plays a critical role in cell cycle arrest, DNA repair and apoptosis 70313
gene_protein 390 amino acid protein 70312
gene_regulation mRNA stability regulated by polyamines and Mdm2 in intestinal mucosal cells 70312
gene_regulation regulated by DNA damage or stress such as hypoxia or nucleotide deprivation 625510