Stat3 (signal transducer and activator of transcription 3) - Rat Genome Database

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Gene: Stat3 (signal transducer and activator of transcription 3) Rattus norvegicus
Analyze
Symbol: Stat3
Name: signal transducer and activator of transcription 3
RGD ID: 3772
Description: Enables CCR5 chemokine receptor binding activity; nuclear glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of hydrogen peroxide biosynthetic process; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within cellular response to cytokine stimulus. Located in cytosol; mitochondrial inner membrane; and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Biomarker of atherosclerosis; colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3); PARTICIPATES IN Interleukin-10 signaling pathway; epidermal growth factor/neuregulin signaling pathway; granulocyte-macrophage colony-stimulating factor signaling pathway; INTERACTS WITH (+)-taxifolin; (R,R,R)-alpha-tocopherol; (S)-colchicine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC93551; signal transducer and activator of transcription 3 (acute-phase response factor)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Pia10
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,311,528 - 86,363,513 (-)NCBIGRCr8
mRatBN7.21085,811,206 - 85,863,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,847,511 - 90,899,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,326,207 - 90,377,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,719,368 - 85,771,150 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
RH 3.4 Map10837.0RGD
Cytogenetic Map10q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Stat3RatAlzheimer's disease  ISOStat3 (Mus musculus)10403051protein:decreased tyrosine phosphorylation:dentate gyrus and CA1 field of hippocampus RGD 
Stat3RatAlzheimer's disease  ISOSTAT3 (Homo sapiens)10403051protein:decreased tyrosine phosphorylation:dentate gyrusRGD 
Stat3Ratangiomyolipoma  ISOSTAT3 (Homo sapiens)2298537protein:increased tyrosine phosphorylation:kidneyRGD 
Stat3Ratangiosarcoma  ISOSTAT3 (Homo sapiens)8694308protein:increased phosphorylation:blood vesselRGD 
Stat3Ratatherosclerosis  IEP 329849122associated with type 2 diabetes mellitus more ...RGD 
Stat3Ratautistic disorder  ISOStat3 (Mus musculus)6483028 RGD 
Stat3Ratbacterial pneumonia  ISOStat3 (Mus musculus)6892945 RGD 
Stat3RatBehcet's disease no_associationISOSTAT3 (Homo sapiens)8694309DNA:SNP: :rs744166 and rs2293152 (human)RGD 
Stat3RatBehcet's disease  ISOSTAT3 (Homo sapiens)6483021DNA:SNP: :rs2293152 (human)RGD 
Stat3RatBrain Injuries  IDA 8694312protein:increased phosphorylation:brainRGD 
Stat3RatBrain Injuries  IDA 6892706 RGD 
Stat3RatBrain Injuries  IMP 6483023 RGD 
Stat3Ratbreast cancer treatmentISOSTAT3 (Homo sapiens)8694286 RGD 
Stat3Ratbreast cancer susceptibilityISOSTAT3 (Homo sapiens)2291912DNA:snpRGD 
Stat3Ratbreast cancer disease_progressionISOSTAT3 (Homo sapiens)8694288 RGD 
Stat3Ratbreast cancer treatmentISOSTAT3 (Homo sapiens)8694291 RGD 
Stat3Ratcardiomyopathy  ISOStat3 (Mus musculus)7495791 RGD 
Stat3Ratcervix uteri carcinoma in situ disease_progressionISOSTAT3 (Homo sapiens)2298536protein:increased serine phosphorylation:cervix epitheliumRGD 
Stat3Ratcervix uteri carcinoma in situ  ISOSTAT3 (Homo sapiens)2291916protein:increased expression:nucleusRGD 
Stat3RatChoroidal Neovascularization treatmentISOStat3 (Mus musculus)8694307 RGD 
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Stat3Ratdiffuse large B-cell lymphoma  ISOSTAT3 (Homo sapiens)8554872ClinVar Annotator: match by term: Diffuse large B cell lymphomaClinVarPMID:21690253 more ...
Stat3Ratfollicular dendritic cell sarcoma  ISOSTAT3 (Homo sapiens)8554872ClinVar Annotator: match by term: EBV-Positive Inflammatory Follicular Dendritic Cell SarcomaClinVarPMID:24797340 more ...
Stat3Ratgenetic disease  ISOSTAT3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:20816194 more ...
Stat3Ratgrowth hormone insensitivity syndrome with immune dysregulation 1  ISOSTAT3 (Homo sapiens)8554872ClinVar Annotator: match by term: Growth hormone insensitivity with immune dysregulation 1 and autosomal recessiveClinVarPMID:28492532
Stat3Rathyper IgE recurrent infection syndrome 1  ISOSTAT3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16199547 more ...
Stat3Rathyper IgE syndrome  ISOSTAT3 (Homo sapiens)8554872ClinVar Annotator: match by term: Hyper-IgE syndromeClinVarPMID:17881745 more ...
Stat3RatMultisystem Autoimmune Disease, Infantile-Onset, 1  ISOSTAT3 (Homo sapiens)8554872ClinVar Annotator: match by term: STAT3-related early-onset multisystem autoimmune diseaseClinVarPMID:16199547 more ...
Stat3Ratprimary immunodeficiency disease  ISOSTAT3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inherited Immunodeficiency DiseasesClinVarPMID:17676033 more ...
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Stat3Ratacute myeloid leukemia  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19796711
Stat3Ratadenocarcinoma  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19028472 and PMID:26432044
Stat3Ratadult T-cell leukemia/lymphoma  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24090995
Stat3Ratanaplastic large cell lymphoma  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22155737
Stat3RatAnimal Disease Models  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25812446
Stat3RatAnimal Mammary Neoplasms  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
Stat3Ratatherosclerosis  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19330073
Stat3RatAtrophy  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16391472
Stat3Ratautoimmune disease  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25038750
Stat3RatB-lymphoblastic leukemia/lymphoma  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19796711
Stat3Ratbrain ischemia  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17901229
Stat3RatBreast Neoplasms  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14975756
Stat3Ratcarcinoma  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16316942
Stat3RatCardiomegaly  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:10618415 more ...
Stat3Ratcardiomyopathy  ISOSTAT3 (Homo sapiens)11554173CTD more ...CTDPMID:10618415 and PMID:24448315
Stat3RatChemical and Drug Induced Liver Injury  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:38460807
Stat3RatChronic Hepatitis  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22879914
Stat3RatColonic Neoplasms  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19028472
Stat3Ratcongenital diaphragmatic hernia  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25812446
Stat3Ratcongestive heart failure  ISOSTAT3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36071497
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Stat3Rathyper IgE recurrent infection syndrome 1  ISOSTAT3 (Homo sapiens)7240710 OMIM 
Stat3RatMultisystem Autoimmune Disease, Infantile-Onset, 1  ISOSTAT3 (Homo sapiens)7240710 OMIM 

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Stat3Rat(+)-taxifolin multiple interactionsEXP 6480464taxifolin inhibits the reaction [Colistin results in decreased expression of STAT3 protein] and taxifolin promotes the reaction [dapagliflozin inhibits the reaction [Colistin results in decreased expression of STAT3 protein]]CTDPMID:33882723
Stat3Rat(-)-Arctigenin multiple interactionsISOStat3 (Mus musculus)6480464arctigenin inhibits the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in increased phosphorylation of and affects the localization of STAT3 protein]CTDPMID:21426947
Stat3Rat(-)-Arctigenin decreases phosphorylationISOSTAT3 (Homo sapiens)6480464arctigenin results in decreased phosphorylation of STAT3 proteinCTDPMID:25380086
Stat3Rat(-)-Arctigenin multiple interactionsISOSTAT3 (Homo sapiens)6480464arctigenin inhibits the reaction [IL6 results in increased expression of STAT3 protein] and Quercetin promotes the reaction [arctigenin results in decreased phosphorylation of STAT3 protein]CTDPMID:25100250 and PMID:25380086
Stat3Rat(-)-cotinine increases phosphorylationISOSTAT3 (Homo sapiens)6480464Cotinine results in increased phosphorylation of STAT3 proteinCTDPMID:31678612
Stat3Rat(-)-demecolcine increases expressionISOSTAT3 (Homo sapiens)6480464Demecolcine results in increased expression of STAT3 mRNACTDPMID:23649840
Stat3Rat(-)-epigallocatechin 3-gallate decreases expressionISOSTAT3 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of STAT3 mRNA more ...CTDPMID:20816778 and PMID:22348037
Stat3Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSTAT3 (Homo sapiens)6480464[docetaxel co-treated with epigallocatechin gallate co-treated with Quercetin] results in decreased expression of and results in decreased phosphorylation of STAT3 protein more ...CTDPMID:25655047
Stat3Rat(-)-epigallocatechin 3-gallate decreases activityISOSTAT3 (Homo sapiens)6480464epigallocatechin gallate results in decreased activity of STAT3 proteinCTDPMID:22348037
Stat3Rat(-)-lobeline multiple interactionsISOSTAT3 (Homo sapiens)6480464[Lobeline binds to and results in decreased activity of [CHRNA4 protein binds to CHRNB2 protein]] inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein] and Lobeline inhibits the reaction [Nicotine results in increased phosphorylation of STAT3 protein]CTDPMID:18448488 and PMID:20106947
Stat3Rat(-)-matairesinol multiple interactionsISOSTAT3 (Homo sapiens)6480464matairesinol inhibits the reaction [IL6 results in increased expression of STAT3 protein]CTDPMID:25100250
Stat3Rat(-)-selegiline multiple interactionsISOStat3 (Mus musculus)6480464[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein]CTDPMID:34609854
Stat3Rat(20R)-protopanaxadiol affects expressionISOSTAT3 (Homo sapiens)6480464protopanaxadiol affects the expression of STAT3 proteinCTDPMID:31805304
Stat3Rat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOStat3 (Mus musculus)6480464Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein] more ...CTDPMID:28739487
Stat3Rat(25R)-cholest-5-ene-3beta,26-diol increases phosphorylationISOSTAT3 (Homo sapiens)648046427-hydroxycholesterol results in increased phosphorylation of STAT3 proteinCTDPMID:27856279
Stat3Rat(25R)-cholest-5-ene-3beta,26-diol multiple interactionsISOSTAT3 (Homo sapiens)6480464Acetylcysteine inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of STAT3 protein] more ...CTDPMID:27856279
Stat3Rat(25R)-cholest-5-ene-3beta,26-diol increases phosphorylationISOStat3 (Mus musculus)648046427-hydroxycholesterol results in increased phosphorylation of STAT3 proteinCTDPMID:28739487
Stat3Rat(R)-lipoic acid multiple interactionsISOSTAT3 (Homo sapiens)6480464Thioctic Acid inhibits the reaction [Cadmium Chloride inhibits the reaction [CNTF results in increased phosphorylation of STAT3 protein]] more ...CTDPMID:19635391 and PMID:28086195
Stat3Rat(R)-noradrenaline increases phosphorylationISOStat3 (Mus musculus)6480464Norepinephrine results in increased phosphorylation of STAT3 proteinCTDPMID:34609854
Stat3Rat(R)-noradrenaline multiple interactionsISOStat3 (Mus musculus)6480464[Clorgyline co-treated with Selegiline] inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein] and Carnosine inhibits the reaction [Norepinephrine results in increased phosphorylation of STAT3 protein]CTDPMID:34609854

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Biological Process
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Original Reference(s)
Stat3Ratacute-phase response  IEP 730023 RGD 
Stat3Ratastrocyte differentiation involved_inISSUniProtKB:P422271600115GO_REF:0000024UniProtGO_REF:0000024
Stat3Ratastrocyte differentiation involved_inISOStat3 (Mus musculus)1624291 PMID:15156153RGDPMID:15156153
Stat3Ratastrocyte differentiation involved_inIEAUniProtKB:P42227 and ensembl:ENSMUSP000001201521600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcell differentiation involved_inISOSTAT3 (Homo sapiens)1624291 PMID:28781374RGDPMID:28781374
Stat3Ratcell differentiation involved_inIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcell population proliferation acts_upstream_of_or_withinISOStat3 (Mus musculus)1624291 PMID:15659653RGDPMID:15659653
Stat3Ratcell population proliferation acts_upstream_of_or_withinIEAUniProtKB:P42227 and ensembl:ENSMUSP000001201521600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcell surface receptor signaling pathway via JAK-STAT  TAS 730023 RGD 
Stat3Ratcell surface receptor signaling pathway via JAK-STAT involved_inIBAFB:FBgn0016917 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stat3Ratcell surface receptor signaling pathway via JAK-STAT involved_inISOSTAT3 (Homo sapiens)1624291 PMID:8272873RGDPMID:8272873
Stat3Ratcell surface receptor signaling pathway via JAK-STAT involved_inIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcell surface receptor signaling pathway via STAT involved_inISOSTAT3 (Homo sapiens)1624291 PMID:25596740RGDPMID:25596740
Stat3Ratcell surface receptor signaling pathway via STAT involved_inIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcellular response to cytokine stimulus acts_upstream_of_or_withinIDA 10402041PMID:19414010MGI 
Stat3Ratcellular response to hormone stimulus involved_inISOSTAT3 (Homo sapiens)1624291 PMID:12552091RGDPMID:12552091
Stat3Ratcellular response to hormone stimulus involved_inIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcellular response to interleukin-17 involved_inIEAUniProtKB:P42227 and ensembl:ENSMUSP000001201521600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcellular response to interleukin-17 involved_inISOStat3 (Mus musculus)1624291 PMID:30294880RGDPMID:30294880
Stat3Ratcellular response to leptin stimulus involved_inISSUniProtKB:P407631600115GO_REF:0000024UniProtGO_REF:0000024
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Cellular Component
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Stat3Ratchromatin located_inIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratchromatin located_inISOSTAT3 (Homo sapiens)1624291 PMID:16835372RGDPMID:16835372
Stat3Ratcytoplasm is_active_inIBAFB:FBgn0016917 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stat3Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Stat3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Stat3Ratcytoplasm is_active_inISOSTAT3 (Homo sapiens)1624291 PMID:12743296RGDPMID:12743296
Stat3Ratcytoplasm located_inIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcytoplasm located_inISOSTAT3 (Homo sapiens)1624291 PMID:15653507 more ...RGDPMID:15653507 more ...
Stat3Ratcytoplasm located_inISSUniProtKB:P422271600115GO_REF:0000024UniProtGO_REF:0000024
Stat3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Stat3Ratcytoplasm is_active_inISOStat3 (Mus musculus)1624291 PMID:16025117RGDPMID:16025117
Stat3Ratcytoplasm located_inIEAUniProtKB:P42227 and ensembl:ENSMUSP000001201521600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcytoplasm located_inIEAUniRule:UR0000464151600115GO_REF:0000104UniProtGO_REF:0000104
Stat3Ratcytoplasm located_inISOStat3 (Mus musculus)1624291 PMID:12634107 more ...RGDPMID:12634107 more ...
Stat3Ratcytosol located_inIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratcytosol located_inTAS 1600115Reactome:R-RNO-198717ReactomeReactome:R-RNO-198717
Stat3Ratcytosol  IDA 8694331 RGD 
Stat3Ratcytosol located_inISOSTAT3 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stat3Ratglutamatergic synapse is_active_inIDA 13702421PMID:22284190SynGO 
Stat3Ratglutamatergic synapse is_active_inIEP 13702421PMID:22284190SynGO 
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Molecular Function
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Stat3RatCCR5 chemokine receptor binding  IPICcr5 (Rattus norvegicus)1582346 RGD 
Stat3Ratchromatin DNA binding enablesIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3Ratchromatin DNA binding enablesISOSTAT3 (Homo sapiens)1624291 PMID:17344214RGDPMID:17344214
Stat3Ratchromatin DNA binding enablesISSUniProtKB:P407631600115GO_REF:0000024UniProtGO_REF:0000024
Stat3RatDNA binding  IDA 730023 RGD 
Stat3RatDNA binding enablesIEAUniProtKB:P42227 and ensembl:ENSMUSP000001201521600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3RatDNA binding enablesIEAInterPro:IPR0138011600115GO_REF:0000002InterProGO_REF:0000002
Stat3RatDNA binding enablesISOStat3 (Mus musculus)1624291 PMID:11579100 more ...RGDPMID:11579100 more ...
Stat3RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Stat3RatDNA binding enablesISSUniProtKB:P422271600115GO_REF:0000024UniProtGO_REF:0000024
Stat3RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOSTAT3 (Homo sapiens)1624291RNAcentral:URS00004E0808_9606 more ...RGDPMID:16835372 more ...
Stat3RatDNA-binding transcription factor activity  TAS 730023 RGD 
Stat3RatDNA-binding transcription factor activity enablesIEAInterPro:IPR001217 and InterPro:IPR0089671600115GO_REF:0000002InterProGO_REF:0000002
Stat3RatDNA-binding transcription factor activity enablesIEAUniProtKB:P42227 and ensembl:ENSMUSP000001201521600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3RatDNA-binding transcription factor activity enablesISOSTAT3 (Homo sapiens)1624291 PMID:15653507 more ...RGDPMID:15653507 more ...
Stat3RatDNA-binding transcription factor activity enablesIEAUniProtKB:P40763 and ensembl:ENSP000002646571600115GO_REF:0000107EnsemblGO_REF:0000107
Stat3RatDNA-binding transcription factor activity enablesISSUniProtKB:P422271600115GO_REF:0000024UniProtGO_REF:0000024
Stat3RatDNA-binding transcription factor activity enablesISSUniProtKB:P407631600115GO_REF:0000024UniProtGO_REF:0000024
Stat3RatDNA-binding transcription factor activity enablesISOStat3 (Mus musculus)1624291 PMID:28065600RGDPMID:28065600
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Original Reference(s)
Stat3Ratacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221
Stat3Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Stat3Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Stat3Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Stat3RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Stat3Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Stat3Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
Stat3Rattoxoplasmosis pathway  IEA 6907045 KEGGrno:05145

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Reference Title
Reference Citation
1. Signal regulatory protein alpha ligation induces macrophage nitric oxide production through JAK/STAT- and phosphatidylinositol 3-kinase/Rac1/NAPDH oxidase/H2O2-dependent pathways. Alblas J, etal., Mol Cell Biol. 2005 Aug;25(16):7181-92. doi: 10.1128/MCB.25.16.7181-7192.2005.
2. Prevention of hypovolemic circulatory collapse by IL-6 activated stat3. Alten JA, etal., PLoS ONE. 2008 Feb 13;3(2):e1605.
3. NF-kappaB and STAT3 inhibition as a therapeutic strategy in psoriasis: in vitro and in vivo effects of BTH. Andres RM, etal., J Invest Dermatol. 2013 Oct;133(10):2362-71. doi: 10.1038/jid.2013.182. Epub 2013 Apr 17.
4. Signal transducer and activator of transcription 3-regulated sarcoendoplasmic reticulum Ca2+-ATPase 2 expression by prolactin and glucocorticoids is involved in the adaptation of insulin secretory response during the peripartum period. Anhe GF, etal., J Endocrinol. 2007 Oct;195(1):17-27.
5. Association of the glucocorticoid receptor with STAT3, C/EBPbeta, and the hormone-responsive element within the rat haptoglobin gene promoter during the acute phase response. Arambasic J, etal., IUBMB Life. 2010 Mar;62(3):227-36.
6. STAT3 deletion sensitizes cells to oxidative stress. Barry SP, etal., Biochem Biophys Res Commun. 2009 Jul 31;385(3):324-9. doi: 10.1016/j.bbrc.2009.05.051. Epub 2009 May 18.
7. The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation. Boengler K, etal., Curr Pharm Des. 2013;19(39):6890-5.
8. ephrinB1 signals from the cell surface to the nucleus by recruitment of STAT3. Bong YS, etal., Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17305-10. Epub 2007 Oct 22.
9. Cytokine G-protein signaling crosstalk in cardiomyocytes: attenuation of Jak-STAT activation by endothelin-1. Booz GW, etal., Mol Cell Biochem 2002 Nov;240(1-2):39-46.
10. Novel role for STAT-5B in the regulation of Hsp27-FGF-2 axis facilitating thrombin-induced vascular smooth muscle cell growth and motility. Cao H, etal., Circ Res. 2006 Apr 14;98(7):913-22. Epub 2006 Mar 9.
11. Influence of the STAT3 genetic variants in the susceptibility to psoriatic arthritis and Behcet's disease. Cenit MC, etal., Hum Immunol. 2013 Feb;74(2):230-3. doi: 10.1016/j.humimm.2012.10.019. Epub 2012 Nov 2.
12. SH2B1beta interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation. Chang YJ, etal., Mol Cell Biol. 2014 Mar;34(6):1003-19. doi: 10.1128/MCB.00940-13. Epub 2014 Jan 6.
13. [Expressions of VEGF/VEGFRs and activation of STATs in ovarian carcinoma] Chen BY, etal., Zhonghua Zhong Liu Za Zhi. 2005 Jan;27(1):33-7.
14. Stat3 activation in human endometrial and cervical cancers. Chen CL, etal., Br J Cancer. 2007 Feb 26;96(4):591-9.
15. Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. Chen JR, etal., J Pharmacol Exp Ther. 2008 Jan;324(1):50-9. Epub 2007 Oct 4.
16. Overexpression of IL-9 induced by STAT3 phosphorylation is mediated by miR-155 and miR-21 in chronic lymphocytic leukemia. Chen N, etal., Oncol Rep. 2018 Jun;39(6):3064-3072. doi: 10.3892/or.2018.6367. Epub 2018 Apr 12.
17. Overexpression of phosphorylated-ATF2 and STAT3 in cutaneous angiosarcoma and pyogenic granuloma. Chen SY, etal., J Cutan Pathol. 2008 Aug;35(8):722-30.
18. Activating transcription factor 4 mediates hyperglycaemia-induced endothelial inflammation and retinal vascular leakage through activation of STAT3 in a mouse model of type 1 diabetes. Chen Y, etal., Diabetologia. 2012 Sep;55(9):2533-45. doi: 10.1007/s00125-012-2594-1. Epub 2012 Jun 4.
19. Clinicopathologic and prognostic significance of VEGF, JAK2 and STAT3 in patients with nasopharyngeal carcinoma. Cheng JZ, etal., Cancer Cell Int. 2018 Aug 13;18:110. doi: 10.1186/s12935-018-0605-0. eCollection 2018.
20. Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons. Chiba T, etal., Mol Psychiatry. 2009 Feb;14(2):206-22. doi: 10.1038/mp.2008.105. Epub 2008 Sep 23.
1 to 20 of 165 rows
1 to 10 of 37 rows
PMID:7510216   PMID:8657134   PMID:8923468   PMID:9872331   PMID:10336453   PMID:10446219   PMID:10464281   PMID:10925297   PMID:11579100   PMID:11710966   PMID:11867182   PMID:11872739  
PMID:12080006   PMID:12242030   PMID:12359225   PMID:12444102   PMID:12477932   PMID:12494267   PMID:12531244   PMID:12552091   PMID:12594516   PMID:12595539   PMID:12634107   PMID:12695539  
PMID:12746441   PMID:12796477   PMID:12817299   PMID:12826573   PMID:12847226   PMID:14678947   PMID:14725620   PMID:14767990   PMID:15004007   PMID:15007380   PMID:15070774   PMID:15096606  
PMID:15156153   PMID:15187153   PMID:15207851   PMID:15256805   PMID:15292470   PMID:15322111   PMID:15469886   PMID:15476586   PMID:15489334   PMID:15548519   PMID:15590660   PMID:15591053  
PMID:15659653   PMID:15664994   PMID:15716400   PMID:15749075   PMID:15860735   PMID:15893771   PMID:15948155   PMID:15948243   PMID:15998644   PMID:16025117   PMID:16127698   PMID:16225866  
PMID:16266461   PMID:16297319   PMID:16300827   PMID:16306356   PMID:16413512   PMID:16514419   PMID:16551428   PMID:16565302   PMID:16616937   PMID:16764840   PMID:16801560   PMID:16809483  
PMID:16825198   PMID:16835372   PMID:16931573   PMID:16934228   PMID:16946298   PMID:16971535   PMID:17031671   PMID:17322172   PMID:17324931   PMID:17326204   PMID:17344214   PMID:17360477  
PMID:17370312   PMID:17463090   PMID:17464217   PMID:17487688   PMID:17498643   PMID:17611279   PMID:17616678   PMID:17716862   PMID:17822789   PMID:17982005   PMID:17993459   PMID:18077446  
PMID:18079966   PMID:18172037   PMID:18178618   PMID:18192274   PMID:18202519   PMID:18234692   PMID:18314882   PMID:18348986   PMID:18365011   PMID:18367451   PMID:18378570   PMID:18411006  
PMID:18499741   PMID:18500485   PMID:18514629   PMID:18567640   PMID:18633737   PMID:18636982   PMID:18665395   PMID:18685078   PMID:18777086   PMID:18798867   PMID:18818315   PMID:18843197  
1 to 10 of 37 rows



Stat3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81086,311,528 - 86,363,513 (-)NCBIGRCr8
mRatBN7.21085,811,206 - 85,863,057 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1090,847,511 - 90,899,338 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01090,326,207 - 90,377,980 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01085,719,368 - 85,771,150 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01088,790,401 - 88,842,263 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,584,605 - 88,638,752 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,821,078 - 89,872,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11089,835,448 - 89,887,340 (-)NCBI
Celera1084,529,054 - 84,580,831 (-)NCBICelera
RH 3.4 Map10837.0RGD
Cytogenetic Map10q31NCBI
STAT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381742,313,324 - 42,388,442 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1742,313,324 - 42,388,568 (-)EnsemblGRCh38hg38GRCh38
GRCh371740,465,342 - 40,540,460 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,718,869 - 37,794,039 (-)NCBINCBI36Build 36hg18NCBI36
Build 341737,718,868 - 37,794,039NCBI
Celera1737,120,227 - 37,194,843 (-)NCBICelera
Cytogenetic Map17q21.2NCBI
HuRef1736,230,024 - 36,304,785 (-)NCBIHuRef
CHM1_11740,701,045 - 40,776,137 (-)NCBICHM1_1
T2T-CHM13v2.01743,169,811 - 43,244,652 (-)NCBIT2T-CHM13v2.0
Stat3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,777,632 - 100,830,447 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11100,775,924 - 100,830,366 (-)EnsemblGRCm39 Ensembl
GRCm3811100,886,806 - 100,939,594 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,885,098 - 100,939,540 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,748,124 - 100,800,825 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611100,702,900 - 100,755,601 (-)NCBIMGSCv36mm8
MGSCv3611101,663,341 - 101,716,042 (-)NCBIMGSCv36mm8
Celera11112,235,347 - 112,235,602 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.82NCBI
Stat3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,319,904 - 16,357,687 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,320,326 - 16,348,505 (-)NCBIChiLan1.0ChiLan1.0
STAT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21922,594,115 - 22,671,720 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11724,486,658 - 24,561,894 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01714,928,689 - 15,003,644 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11715,152,358 - 15,227,084 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,152,358 - 15,227,067 (+)Ensemblpanpan1.1panPan2
STAT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1920,539,660 - 20,614,631 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl920,539,697 - 20,612,672 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha920,001,678 - 20,076,249 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0921,258,611 - 21,334,353 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl921,258,632 - 21,334,351 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1920,044,250 - 20,119,519 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0920,309,625 - 20,386,466 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0920,413,942 - 20,489,100 (+)NCBIUU_Cfam_GSD_1.0
Stat3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560219,877,467 - 19,955,950 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493649017,117,290 - 17,178,402 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493649017,119,189 - 17,178,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,407,233 - 20,472,992 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,407,316 - 20,471,091 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,709,840 - 20,775,669 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11663,877,884 - 63,957,894 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1663,922,862 - 63,957,984 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607734,685,072 - 34,769,191 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247951,648,080 - 1,681,200 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247951,648,235 - 1,680,788 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Stat3
220 total Variants

Predicted Target Of
Summary Value
Count of predictions:674
Count of miRNA genes:285
Interacting mature miRNAs:370
Transcripts:ENSRNOT00000026760
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 79 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)104114263386142633Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
631555Bp134Blood pressure QTL 1340.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)108051528791230079Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
4889948Bss91Bone structure and strength QTL 914tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)108256485692369470Rat

1 to 10 of 79 rows
BF417681  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,353,513 - 86,353,664 (+)Marker Load Pipeline
mRatBN7.21085,853,211 - 85,853,362 (+)MAPPERmRatBN7.2
Rnor_6.01088,832,388 - 88,832,538NCBIRnor6.0
Rnor_5.01088,628,605 - 88,628,755UniSTSRnor5.0
RGSC_v3.41089,863,124 - 89,863,274UniSTSRGSC3.4
Celera1084,570,986 - 84,571,136UniSTS
RH 3.4 Map10860.3UniSTS
Cytogenetic Map10q32.1UniSTS
PMC303343P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,814,078 - 85,814,309 (+)MAPPERmRatBN7.2
Rnor_6.01088,793,267 - 88,793,497NCBIRnor6.0
Rnor_5.01088,587,471 - 88,587,701UniSTSRnor5.0
RGSC_v3.41089,823,939 - 89,824,169UniSTSRGSC3.4
Celera1084,531,915 - 84,532,145UniSTS
Cytogenetic Map10q32.1UniSTS
RH94819  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81086,312,895 - 86,313,138 (+)Marker Load Pipeline
mRatBN7.21085,812,579 - 85,812,822 (+)MAPPERmRatBN7.2
Rnor_6.01088,791,770 - 88,792,012NCBIRnor6.0
Rnor_5.01088,585,974 - 88,586,216UniSTSRnor5.0
RGSC_v3.41089,822,442 - 89,822,684UniSTSRGSC3.4
Celera1084,530,418 - 84,530,660UniSTS
RH 3.4 Map10837.0UniSTS
Cytogenetic Map10q32.1UniSTS
RH143302  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,812,832 - 85,812,936 (+)MAPPERmRatBN7.2
Rnor_6.01088,792,023 - 88,792,126NCBIRnor6.0
Rnor_5.01088,586,227 - 88,586,330UniSTSRnor5.0
RGSC_v3.41089,822,695 - 89,822,798UniSTSRGSC3.4
Celera1084,530,671 - 84,530,774UniSTS
RH 3.4 Map10860.9UniSTS
Cytogenetic Map10q32.1UniSTS
PMC317074P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21085,814,078 - 85,814,309 (+)MAPPERmRatBN7.2
Rnor_6.01088,793,267 - 88,793,497NCBIRnor6.0
Rnor_5.01088,587,471 - 88,587,701UniSTSRnor5.0
RGSC_v3.41089,823,939 - 89,824,169UniSTSRGSC3.4
Celera1084,531,915 - 84,532,145UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_001430046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001430048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006247259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087025 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225489 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU477503 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU477504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X91810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000026760   ⟹   ENSRNOP00000026760
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,811,218 - 85,863,057 (-)Ensembl
Rnor_6.0 Ensembl1088,790,408 - 88,842,233 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119716   ⟹   ENSRNOP00000092154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1085,811,218 - 85,837,739 (-)Ensembl
RefSeq Acc Id: NM_012747   ⟹   NP_036879
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,311,533 - 86,363,359 (-)NCBI
mRatBN7.21085,811,216 - 85,863,057 (-)NCBI
Rnor_6.01088,790,406 - 88,842,233 (-)NCBI
Rnor_5.01088,584,605 - 88,638,752 (-)NCBI
RGSC_v3.41089,821,078 - 89,872,970 (-)RGD
Celera1084,529,054 - 84,580,831 (-)RGD
Sequence:
RefSeq Acc Id: XM_006247257   ⟹   XP_006247319
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,311,528 - 86,363,513 (-)NCBI
mRatBN7.21085,811,206 - 85,836,607 (-)NCBI
Rnor_6.01088,790,401 - 88,842,263 (-)NCBI
Rnor_5.01088,584,605 - 88,638,752 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247258   ⟹   XP_006247320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,313,347 - 86,363,513 (-)NCBI
mRatBN7.21085,811,206 - 85,836,607 (-)NCBI
Rnor_6.01088,790,401 - 88,842,263 (-)NCBI
Rnor_5.01088,584,605 - 88,638,752 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006247259   ⟹   XP_006247321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81086,313,347 - 86,363,513 (-)NCBI
mRatBN7.21085,811,206 - 85,836,607 (-)NCBI
Rnor_6.01088,790,401 - 88,842,263 (-)NCBI
Rnor_5.01088,584,605 - 88,638,752 (-)NCBI
Sequence:
RefSeq Acc Id: NP_036879   ⟸   NM_012747
- UniProtKB: P52631 (UniProtKB/Swiss-Prot),   A6HJ64 (UniProtKB/TrEMBL),   A0A8I6GJJ3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006247321   ⟸   XM_006247259
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006247320   ⟸   XM_006247258
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_006247319   ⟸   XM_006247257
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000026760   ⟸   ENSRNOT00000026760
SH2

Name Modeler Protein Id AA Range Protein Structure
AF-P52631-F1-model_v2 AlphaFold P52631 1-770 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697735
Promoter ID:EPDNEW_R8260
Type:initiation region
Name:Stat3_1
Description:signal transducer and activator of transcription 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01088,842,214 - 88,842,274EPDNEW


1 to 40 of 44 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-23210 BioCyc
Ensembl Genes ENSRNOG00000019742 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026760 ENTREZGENE
  ENSRNOT00000026760.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.532.10 UniProtKB/Swiss-Prot
  2.60.40.630 UniProtKB/Swiss-Prot
  3.30.505.10 UniProtKB/Swiss-Prot
  EF-hand UniProtKB/Swiss-Prot
  STAT transcription factor, all-alpha domain UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7110655 IMAGE-MGC_LOAD
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  STAT UniProtKB/Swiss-Prot
  STAT3_SH2 UniProtKB/Swiss-Prot
  STAT_linker UniProtKB/Swiss-Prot
  STAT_N_sf UniProtKB/Swiss-Prot
  STAT_TF_alpha UniProtKB/Swiss-Prot
  STAT_TF_coiled-coil UniProtKB/Swiss-Prot
  STAT_TF_DNA-bd UniProtKB/Swiss-Prot
  STAT_TF_DNA-bd_N UniProtKB/Swiss-Prot
  STAT_TF_prot_interaction UniProtKB/Swiss-Prot
KEGG Report rno:25125 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93551 IMAGE-MGC_LOAD
NCBI Gene 25125 ENTREZGENE
PANTHER PTHR11801 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
  STAT_alpha UniProtKB/Swiss-Prot
  STAT_bind UniProtKB/Swiss-Prot
  STAT_int UniProtKB/Swiss-Prot
  STAT_linker UniProtKB/Swiss-Prot
PharmGKB STAT3 RGD
PhenoGen Stat3 PhenoGen
PROSITE SH2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019742 RatGTEx
SMART STAT_int UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47655 UniProtKB/Swiss-Prot
  SSF48092 UniProtKB/Swiss-Prot
  SSF49417 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
1 to 40 of 44 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Stat3  signal transducer and activator of transcription 3  Stat3  signal transducer and activator of transcription 3 (acute-phase response factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-02-02 Stat3  signal transducer and activator of transcription 3 (acute-phase response factor)  Stat3  signal transducer and activator of transcription 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Stat3  signal transducer and activator of transcription 3      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_function transcription factor that binds to the interleukin-6 (IL-6)-responsive elements in the promoters of acute-phase protein genes 61073
gene_process involved in the gp130-mediated signaling pathway 61073
gene_process persistent phosphorylation in the hypothalamus is correlated with leptin-induced leptin resistance 625717