Stat1 (signal transducer and activator of transcription 1) - Rat Genome Database

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Gene: Stat1 (signal transducer and activator of transcription 1) Rattus norvegicus
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Symbol: Stat1
Name: signal transducer and activator of transcription 1
RGD ID: 3771
Description: Enables CCR5 chemokine receptor binding activity; protein phosphatase 2A binding activity; and sequence-specific DNA binding activity. Involved in several processes, including cell surface receptor signaling pathway via JAK-STAT; positive regulation of nitric oxide biosynthetic process; and positive regulation of smooth muscle cell proliferation. Acts upstream of or within cellular response to cytokine stimulus. Located in axon and dendrite. Used to study pulmonary fibrosis. Human ortholog(s) of this gene implicated in adenocarcinoma (multiple); breast cancer (multiple); immunodeficiency 31A; immunodeficiency 31B; and immunodeficiency 31C. Orthologous to human STAT1 (signal transducer and activator of transcription 1); PARTICIPATES IN Jak-Stat signaling pathway; epidermal growth factor/neuregulin signaling pathway; erythropoietin signaling pathway; INTERACTS WITH (+)-schisandrin B; 15-deoxy-Delta(12,14)-prostaglandin J2; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DD6G4-4; signal transducer and activator of transcription 1-alpha/beta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,911,522 - 56,951,926 (-)NCBIGRCr8
mRatBN7.2949,419,561 - 49,459,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,969,129 - 58,009,299 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,091,965 - 63,132,135 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,387,952 - 61,428,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,287,540 - 54,327,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,998,204 - 54,038,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,455,635 - 46,497,560 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,458,584 - 46,495,612 (-)NCBI
Celera947,082,882 - 47,123,002 (-)NCBICelera
Cytogenetic Map9q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Stat1Ratangiomyolipoma  ISOSTAT1 (Homo sapiens)2298537protein:increased serine phosphorylation:kidneyRGD 
Stat1RatBrain Injuries  IMP 6483023 RGD 
Stat1Ratbreast cancer disease_progressionISOSTAT1 (Homo sapiens)2291892protein:increased expression:breastRGD 
Stat1Ratbreast carcinoma disease_progressionISOSTAT1 (Homo sapiens)2291894protein:increased activity:breastRGD 
Stat1Ratcolon adenocarcinoma  ISOSTAT1 (Homo sapiens)153323313DNA:SNPs:introns: (rs2280232 and rs4327257) (human)RGD 
Stat1RatCOVID-19  ISOSTAT1 (Homo sapiens)9068941mRNA:increased expression:bronchoalveolar lavage (human)RGDPMID:32407669 and REF_RGD_ID:30296672
Stat1RatExperimental Arthritis  IDA 1582346protein:increased tyrosine phosphorylation:macrophage and synovial cell RGD 
Stat1RatExperimental Autoimmune Encephalomyelitis  ISOStat1 (Mus musculus)6483041 RGD 
Stat1RatExperimental Diabetes Mellitus  IDA 1600105protein:increased tyrosine phosphorylation:glomerulusRGD 
Stat1RatExperimental Mammary Neoplasms  ISOStat1 (Mus musculus)2291895 RGD 
Stat1Ratgastric adenocarcinoma exacerbatesISOSTAT1 (Homo sapiens)153298934mRNA:increased expression:stomach (human)RGD 
Stat1Rathepatitis C  ISOSTAT1 (Homo sapiens)11074283protein:increased expression:liverRGD 
Stat1Ratlymphangioleiomyomatosis  ISOSTAT1 (Homo sapiens)2298537protein:increased serine phosphorylation:lungRGD 
Stat1Ratlymphocytic choriomeningitis exacerbatesISOStat1 (Mus musculus)124715469 RGD 
Stat1RatMyocardial Reperfusion Injury  IDA 1600091protein:increased phosphorylation:heartRGD 
Stat1Ratnephroblastoma  ISOSTAT1 (Homo sapiens)2291893protein:increased serine phosphorylation:kidneyRGD 
Stat1RatNervous System Trauma  IDA 1600090protein:increased phosphorylation:ganglionRGD 
Stat1RatNontuberculous Mycobacterium Infections susceptibilityISOSTAT1 (Homo sapiens)1600087DNA:transition: and 2116T>CRGD 
Stat1Ratpancreatic adenocarcinoma amelioratesISOSTAT1 (Homo sapiens)155630608protein:increased expression:pancreas (human)RGD 
Stat1Ratperiodontitis treatmentISOStat1 (Mus musculus)18936995 RGD 
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Original Reference(s)
Stat1Ratchronic mucocutaneous candidiasis  ISOSTAT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Chronic mucocutaneous candidiasisClinVarPMID:21714643 more ...
Stat1Ratgenetic disease  ISOSTAT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24343863 more ...
Stat1Ratimmunodeficiency 31A  ISOSTAT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11452125 more ...
Stat1Ratimmunodeficiency 31B  ISOSTAT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12590259 more ...
Stat1Ratimmunodeficiency 31C  ISOSTAT1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:17576681 more ...
Stat1RatNeurodevelopmental Disorders  ISOSTAT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Neurodevelopmental disorderClinVarPMID:25741868
Stat1RatNontuberculous Mycobacterium Infections  ISOSTAT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Familial Atypical Mycobacteriosis and Autosomal DominantClinVar 
Stat1Ratprimary immunodeficiency disease  ISOSTAT1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inherited Immunodeficiency DiseasesClinVarPMID:21727188 more ...
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Stat1Ratchronic mucocutaneous candidiasis  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21714643
Stat1RatCytomegalovirus Infections  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16688530
Stat1RatDisease Progression  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22488367
Stat1RatExperimental Arthritis  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15188379
Stat1RatHearing Loss  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20712533
Stat1Rathepatocellular carcinoma  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22488367
Stat1RatHuman Influenza  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23326326
Stat1Ratliver cirrhosis  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:17133483
Stat1Ratlupus nephritis  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31182691
Stat1RatMycobacterium Infections  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11452125
Stat1RatNeoplasm Metastasis  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29147627
Stat1Ratrheumatoid arthritis  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12833524
Stat1RatT-cell acute lymphoblastic leukemia  ISOSTAT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23471820
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Stat1Ratbreast cancer  ISSStat1 (Mus musculus)13592920OMIM:114480MouseDO 
Stat1Ratsevere acute respiratory syndrome  ISSStat1 (Mus musculus)13592920 MouseDO 
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Stat1Ratimmunodeficiency 31A  ISOSTAT1 (Homo sapiens)7240710 OMIM 
Stat1Ratimmunodeficiency 31B  ISOSTAT1 (Homo sapiens)7240710 OMIM 
Stat1Ratimmunodeficiency 31C  ISOSTAT1 (Homo sapiens)7240710 OMIM 

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Stat1Rat(+)-alpha-viniferin multiple interactionsISOStat1 (Mus musculus)6480464alpha-viniferin inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein] and alpha-viniferin inhibits the reaction [MAPK9 protein results in increased phosphorylation of and results in increased activity of STAT1 protein]CTDPMID:20424383
Stat1Rat(+)-catechin decreases expressionISOSTAT1 (Homo sapiens)6480464Catechin results in decreased expression of STAT1 mRNA and Catechin results in decreased expression of STAT1 proteinCTDPMID:15465739
Stat1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of STAT1 mRNA]CTDPMID:31150632
Stat1Rat(+)-taxifolin multiple interactionsISOSTAT1 (Homo sapiens)6480464taxifolin inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of STAT1 protein]CTDPMID:12044887
Stat1Rat(-)-alpha-phellandrene increases expressionISOSTAT1 (Homo sapiens)6480464alpha phellandrene results in increased expression of STAT1 mRNACTDPMID:25075043
Stat1Rat(-)-Arctigenin multiple interactionsISOStat1 (Mus musculus)6480464arctigenin inhibits the reaction [lipopolysaccharide and Escherichia coli O111 B4 results in increased phosphorylation of and affects the localization of STAT1 protein]CTDPMID:21426947
Stat1Rat(-)-Arctigenin multiple interactionsISOSTAT1 (Homo sapiens)6480464arctigenin inhibits the reaction [IFNG results in increased expression of STAT1 protein]CTDPMID:25100250
Stat1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSTAT1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of STAT1 mRNACTDPMID:22079256
Stat1Rat(-)-epigallocatechin 3-gallate decreases expressionISOSTAT1 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of STAT1 mRNACTDPMID:32512070
Stat1Rat(1->4)-beta-D-glucan multiple interactionsISOStat1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of STAT1 mRNACTDPMID:36331819
Stat1Rat(R)-lipoic acid multiple interactionsISOSTAT1 (Homo sapiens)6480464Thioctic Acid affects the reaction [Zinc deficiency affects the phosphorylation of STAT1 protein] more ...CTDPMID:19635391 and PMID:28086195
Stat1Rat(S)-colchicine multiple interactionsISOSTAT1 (Homo sapiens)6480464Colchicine deficiency results in decreased activity of and affects the localization of STAT1 proteinCTDPMID:28086195
Stat1Rat(S)-naringenin multiple interactionsISOSTAT1 (Homo sapiens)6480464[naringenin metabolite co-treated with bisphenol A] results in decreased expression of STAT1 mRNACTDPMID:36235125
Stat1Rat(S)-nicotine multiple interactionsISOSTAT1 (Homo sapiens)6480464Nicotine inhibits the reaction [Poly I-C results in increased expression of STAT1 mRNA]CTDPMID:31154625
Stat1Rat1,2-dimethylhydrazine decreases expressionISOStat1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of STAT1 mRNACTDPMID:22206623
Stat1Rat1,4-benzoquinone multiple interactionsISOSTAT1 (Homo sapiens)6480464quinone promotes the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of STAT1 protein]CTDPMID:31248982
Stat1Rat1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactionsISOSTAT1 (Homo sapiens)64804641-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [CNTF protein affects the phosphorylation of and affects the activity of STAT1 protein]CTDPMID:11882386
Stat1Rat1-chloro-2,4-dinitrobenzene decreases expressionISOSTAT1 (Homo sapiens)6480464Dinitrochlorobenzene results in decreased expression of STAT1 mRNACTDPMID:17374397
Stat1Rat1-chloro-2,4-dinitrobenzene affects bindingISOSTAT1 (Homo sapiens)6480464Dinitrochlorobenzene binds to STAT1 proteinCTDPMID:32991956
Stat1Rat1-naphthyl isothiocyanate multiple interactionsISOSTAT1 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of STAT1 mRNACTDPMID:27344345

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Biological Process
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Stat1Ratblood circulation  IMP 2291903 RGD 
Stat1Ratcell population proliferation involved_inISOStat1 (Mus musculus)1624291MGI:107670 more ...RGDPMID:15781341
Stat1Ratcell surface receptor signaling pathway via JAK-STAT  IMP 1299060 RGD 
Stat1Ratcell surface receptor signaling pathway via JAK-STAT  TAS 1299057 RGD 
Stat1Ratcell surface receptor signaling pathway via JAK-STAT involved_inISOStat1 (Mus musculus)1624291 PMID:11972023RGDPMID:11972023
Stat1Ratcell surface receptor signaling pathway via JAK-STAT involved_inIBAFB:FBgn0016917 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stat1Ratcell surface receptor signaling pathway via JAK-STAT involved_inISOSTAT1 (Homo sapiens)1624291 PMID:11972023 more ...RGDPMID:11972023 more ...
Stat1Ratcell surface receptor signaling pathway via STAT involved_inISOSTAT1 (Homo sapiens)1624291 PMID:18035482RGDPMID:18035482
Stat1Ratcellular response to cytokine stimulus acts_upstream_of_or_withinIDA 10402041PMID:19414010MGI 
Stat1Ratcellular response to insulin stimulus  IDA 1600096 RGD 
Stat1Ratcellular response to interferon-beta involved_inISOSTAT1 (Homo sapiens)1624291 PMID:18035482 and PMID:28753426RGDPMID:18035482 and PMID:28753426
Stat1Ratcellular response to lipopolysaccharide acts_upstream_of_or_withinISOStat1 (Mus musculus)1624291MGI:1861949 PMID:21606371RGDPMID:21606371
Stat1Ratcellular response to type II interferon involved_inISOSTAT1 (Homo sapiens)1624291 PMID:11972023 and PMID:23386060RGDPMID:11972023 and PMID:23386060
Stat1Ratcytokine-mediated signaling pathway acts_upstream_of_or_withinISOStat1 (Mus musculus)1624291 PMID:12872135RGDPMID:12872135
Stat1Ratdefense response involved_inIBAFB:FBgn0016917 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stat1Ratdefense response to virus involved_inISOSTAT1 (Homo sapiens)1624291 PMID:28753426RGDPMID:28753426
Stat1Ratdefense response to virus involved_inISOStat1 (Mus musculus)1624291 PMID:32270034RGDPMID:32270034
Stat1RatDNA-templated transcription acts_upstream_of_or_withinISOStat1 (Mus musculus)1624291 PMID:15485925RGDPMID:15485925
Stat1Ratendothelial cell migration NOT|involved_inISOSTAT1 (Homo sapiens)1624291 PMID:16585190RGDPMID:16585190
Stat1Ratinterleukin-27-mediated signaling pathway involved_inISOSTAT1 (Homo sapiens)1624291 PMID:32270034RGDPMID:32270034
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Cellular Component
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Stat1Rataxon  IDA 1600107 RGD 
Stat1Ratchromatin located_inISOSTAT1 (Homo sapiens)1624291 PMID:18035482RGDPMID:18035482
Stat1Ratcytoplasm is_active_inIBAFB:FBgn0016917 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stat1Ratcytoplasm located_inIEAUniRule:UR0000464151600115GO_REF:0000104UniProtGO_REF:0000104
Stat1Ratcytoplasm located_inISOStat1 (Mus musculus)1624291 PMID:12634107 more ...RGDPMID:12634107 more ...
Stat1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Stat1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Stat1Ratcytoplasm located_inIEAARBA:ARBA000269711600115GO_REF:0000117UniProtGO_REF:0000117
Stat1Ratcytoplasm located_inISOSTAT1 (Chlorocebus sabaeus)1624291 PMID:26889034RGDPMID:26889034
Stat1Ratcytoplasm located_inISOSTAT1 (Homo sapiens)1624291 PMID:10692450 more ...RGDPMID:10692450 more ...
Stat1Ratcytosol located_inISOSTAT1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stat1Ratdendrite  IDA 1600107 RGD 
Stat1RatISGF3 complex part_ofIBAPANTHER:PTN002623830 and UniProtKB:P422241600115GO_REF:0000033GO_CentralGO_REF:0000033
Stat1RatISGF3 complex part_ofISOSTAT1 (Homo sapiens)1624291 PMID:24065129RGDPMID:24065129
Stat1Ratnucleolus located_inISOSTAT1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stat1Ratnucleoplasm located_inISOSTAT1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Stat1Ratnucleus is_active_inIBAFB:FBgn0016917 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stat1Ratnucleus located_inISOStat1 (Mus musculus)1624291 PMID:12957148RGDPMID:12957148
Stat1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Stat1Ratnucleus located_inIEAUniRule:UR0000464151600115GO_REF:0000104UniProtGO_REF:0000104
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Molecular Function
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Stat1RatCCR5 chemokine receptor binding  IPICcr5 (Rattus norvegicus)1582346 RGD 
Stat1RatDNA binding  IDA 1600110 RGD 
Stat1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Stat1RatDNA binding enablesIEAInterPro:IPR0138011600115GO_REF:0000002InterProGO_REF:0000002
Stat1RatDNA-binding transcription factor activity NOT|enablesISOSTAT1 (Homo sapiens) and UniProtKB:P42224-21624291 PMID:10820245RGDPMID:10820245
Stat1RatDNA-binding transcription factor activity  TAS 1299057 RGD 
Stat1RatDNA-binding transcription factor activity enablesISOStat1 (Mus musculus)1624291 PMID:15485925 and PMID:37327784RGDPMID:15485925 and PMID:37327784
Stat1RatDNA-binding transcription factor activity enablesIEAInterPro:IPR001217 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Stat1RatDNA-binding transcription factor activity enablesISOSTAT1 (Homo sapiens)1624291 PMID:10973496 more ...RGDPMID:10973496 more ...
Stat1RatDNA-binding transcription factor activity enablesIEAInterPro:IPR001217 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Stat1RatDNA-binding transcription factor activity enablesISOSTAT1 (Homo sapiens) and UniProtKB:P42224-11624291 PMID:10820245RGDPMID:10820245
Stat1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOSTAT1 (Homo sapiens)1624291 PMID:11972023 more ...RGDPMID:11972023 more ...
Stat1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOStat1 (Mus musculus)1624291 PMID:11972023RGDPMID:11972023
Stat1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0016917 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Stat1Ratdouble-stranded DNA binding enablesISOSTAT1 (Homo sapiens)1624291 PMID:9630226RGDPMID:9630226
Stat1Ratenzyme binding enablesISOSTAT1 (Homo sapiens)1624291UniProtKB:Q8IXQ6 more ...RGDPMID:26479788
Stat1Rathistone acetyltransferase binding enablesISOSTAT1 (Homo sapiens)1624291UniProtKB:Q09472 and PMID:26479788RGDPMID:26479788
Stat1Rathistone binding enablesISOSTAT1 (Homo sapiens)1624291UniProtKB:Q93079 and PMID:26479788RGDPMID:26479788
Stat1Ratidentical protein binding enablesISOSTAT1 (Homo sapiens)1624291UniProtKB:P42224 more ...RGDPMID:8605877 and PMID:9630226
Stat1Ratidentical protein binding enablesISOSTAT1 (Homo sapiens) and UniProtKB:P42224-11624291UniProtKB:P42224-1 and PMID:18591661RGDPMID:18591661
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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Stat1Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Stat1Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Stat1Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Stat1Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Stat1RatJak-Stat signaling pathway   IEA 6907045 KEGGrno:04630
Stat1RatLeishmaniasis pathway  IEA 6907045 KEGGrno:05140
Stat1Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Stat1Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
Stat1RatToll-like receptor signaling pathway   IEA 6907045 KEGGrno:04620
Stat1Rattoxoplasmosis pathway  IEA 6907045 KEGGrno:05145
Stat1Rattuberculosis pathway  IEA 6907045 KEGGrno:05152
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Reference Title
Reference Citation
1. Specific transcription factors prognostic for prostate cancer progression. Aoyagi K, etal., Clin Cancer Res. 1998 Sep;4(9):2153-60.
2. Angiotensin II blockade prevents hyperglycemia-induced activation of JAK and STAT proteins in diabetic rat kidney glomeruli. Banes AK, etal., Am J Physiol Renal Physiol. 2004 Apr;286(4):F653-9. Epub 2003 Dec 16.
3. Upregulation of Penile Brain-Derived Neurotrophic Factor (BDNF) and Activation of the JAK/STAT Signalling Pathway in the Major Pelvic Ganglion of the Rat After Cavernous Nerve Transection. Bella AJ, etal., Eur Urol. 2006 Oct 30;.
4. Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Bhanoori M, etal., Oncogene 2003 Jan 9;22(1):117-30.
5. Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. Buess M, etal., Genome Biol. 2007;8(9):R191.
6. Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. Chen G, etal., J Biol Chem 2001 Jan 5;276(1):766-72.
7. Differentiation decreased telomerase activity in rat glioblastoma C6 cells and increased sensitivity to IFN-gamma and taxol for apoptosis. Das A, etal., Neurochem Res. 2007 Dec;32(12):2167-83. Epub 2007 Aug 13.
8. Impairment of mycobacterial but not viral immunity by a germline human STAT1 mutation. Dupuis S, etal., Science. 2001 Jul 13;293(5528):300-3.
9. Interferon-gamma-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target. El-Hashemite N and Kwiatkowski DJ, Am J Respir Cell Mol Biol. 2005 Sep;33(3):227-30. Epub 2005 Jun 30.
10. [STAT1 antisense oligonucleotides inhibit secretion of TNF-alpha, IL-8 and NO in alveolar macrophages of rats suffering from interstitial pulmonary fibrosis] Fan XM, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006 Jul;22(4):487-9, 492.
11. Transcriptional activation of the IL-6 response element in the junB promoter is mediated by multiple Stat family proteins. Fujitani Y, etal., Biochem Biophys Res Commun. 1994 Jul 29;202(2):1181-7.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Specific localization of signal transducer and activator of transcription 1 immunoreactivity in oxytocin neurons of the rat hypothalamus. Gautron L, etal., Brain Res. 2003 Dec 24;994(2):260-4.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. JAK-STAT signaling pathways are activated in the brain following reovirus infection. Goody RJ, etal., J Neurovirol. 2007 Aug;13(4):373-83.
16. Exposure of glia to pro-oxidant agents revealed selective Stat1 activation by H2O2 and Jak2-independent antioxidant features of the Jak2 inhibitor AG490. Gorina R, etal., Glia. 2007 Oct;55(13):1313-24.
17. Vitamin C inhibits hypoxia-induced damage and apoptotic signaling pathways in cardiomyocytes and ischemic hearts. Guaiquil VH, etal., Free Radic Biol Med. 2004 Nov 1;37(9):1419-29.
18. Identification of immune checkpoint inhibitors and biomarkers among STAT family in stomach adenocarcinoma. Guo L, etal., Am J Transl Res. 2020 Sep 15;12(9):4977-4997. eCollection 2020.
19. Mice deficient in STAT1 but not STAT2 or IRF9 develop a lethal CD4+ T-cell-mediated disease following infection with lymphocytic choriomeningitis virus. Hofer MJ, etal., J Virol. 2012 Jun;86(12):6932-46. doi: 10.1128/JVI.07147-11. Epub 2012 Apr 11.
20. Amelioration of experimental autoimmune encephalomyelitis by plumbagin through down-regulation of JAK-STAT and NF-kappaB signaling pathways. Jia Y, etal., PLoS One. 2011;6(10):e27006. Epub 2011 Oct 31.
1 to 20 of 66 rows
PMID:1299057   PMID:8605877   PMID:8657134   PMID:8889548   PMID:9630226   PMID:10692450   PMID:10820245   PMID:10848577   PMID:10973496   PMID:12138178   PMID:12538627   PMID:12634107  
PMID:12872135   PMID:12947022   PMID:12957148   PMID:14522949   PMID:14984365   PMID:15485925   PMID:15590660   PMID:15630703   PMID:15659221   PMID:15661922   PMID:15825084   PMID:15956343  
PMID:16027122   PMID:16212889   PMID:16255958   PMID:16306601   PMID:16555329   PMID:16585190   PMID:16616937   PMID:17116388   PMID:17251186   PMID:17275127   PMID:17505916   PMID:17982005  
PMID:18035482   PMID:18348986   PMID:18499741   PMID:18511434   PMID:18514629   PMID:18582404   PMID:18591661   PMID:18721488   PMID:19176616   PMID:19182904   PMID:19426591   PMID:19563079  
PMID:19606498   PMID:19609277   PMID:19615126   PMID:19781632   PMID:19782030   PMID:20117981   PMID:20307504   PMID:20861313   PMID:20980260   PMID:21069420   PMID:21102409   PMID:21268089  
PMID:21396905   PMID:21419645   PMID:21545521   PMID:21606371   PMID:21929289   PMID:22002246   PMID:22302831   PMID:22865856   PMID:23386060   PMID:23451164   PMID:24097101   PMID:24280128  
PMID:24598055   PMID:24882218   PMID:25129435   PMID:25468996   PMID:25986861   PMID:26479788   PMID:26617765   PMID:27742579   PMID:27796300   PMID:27940139   PMID:27994058   PMID:28086195  
PMID:28129651   PMID:28283061   PMID:28601953   PMID:28753426   PMID:28782829   PMID:31982878   PMID:32503893   PMID:32741247   PMID:35124149   PMID:37199563   PMID:37365519   PMID:37479855  
PMID:37920469  



Stat1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8956,911,522 - 56,951,926 (-)NCBIGRCr8
mRatBN7.2949,419,561 - 49,459,969 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl949,419,340 - 49,588,540 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx957,969,129 - 58,009,299 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0963,091,965 - 63,132,135 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0961,387,952 - 61,428,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0954,287,540 - 54,327,958 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl954,287,541 - 54,484,533 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0953,998,204 - 54,038,463 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4946,455,635 - 46,497,560 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1946,458,584 - 46,495,612 (-)NCBI
Celera947,082,882 - 47,123,002 (-)NCBICelera
Cytogenetic Map9q22NCBI
STAT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382190,969,149 - 191,014,171 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2190,908,460 - 191,020,960 (-)EnsemblGRCh38hg38GRCh38
GRCh372191,833,875 - 191,878,897 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362191,542,121 - 191,587,181 (-)NCBINCBI36Build 36hg18NCBI36
Build 342191,665,769 - 191,704,442NCBI
Celera2185,428,361 - 185,473,577 (-)NCBICelera
Cytogenetic Map2q32.2NCBI
HuRef2183,693,413 - 183,738,626 (-)NCBIHuRef
CHM1_12191,839,599 - 191,884,801 (-)NCBICHM1_1
T2T-CHM13v2.02191,458,256 - 191,503,284 (-)NCBIT2T-CHM13v2.0
Stat1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39152,158,588 - 52,201,024 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl152,158,599 - 52,201,024 (+)EnsemblGRCm39 Ensembl
GRCm38152,119,438 - 52,161,865 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl152,119,440 - 52,161,865 (+)EnsemblGRCm38mm10GRCm38
MGSCv37152,176,282 - 52,218,707 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36152,064,002 - 52,105,508 (+)NCBIMGSCv36mm8
Celera152,657,880 - 52,700,334 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map126.81NCBI
Stat1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554038,156,660 - 8,194,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554038,156,660 - 8,192,018 (+)NCBIChiLan1.0ChiLan1.0
STAT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21393,651,032 - 93,700,280 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B93,666,016 - 93,711,687 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B78,270,642 - 78,316,074 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B196,186,906 - 196,232,280 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B196,186,906 - 196,232,280 (-)Ensemblpanpan1.1panPan2
STAT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1371,513,438 - 1,549,837 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl371,507,219 - 1,550,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha372,461,622 - 2,502,035 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0371,400,933 - 1,441,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl371,395,727 - 1,441,301 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1371,410,525 - 1,450,952 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0371,378,532 - 1,418,954 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0371,407,084 - 1,447,502 (-)NCBIUU_Cfam_GSD_1.0
Stat1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303149,602,218 - 149,641,217 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365067,196,797 - 7,233,756 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365067,196,860 - 7,235,854 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1595,593,211 - 95,646,260 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11595,593,201 - 95,646,324 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
STAT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11076,492,859 - 76,537,689 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1076,492,533 - 76,533,393 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040122,939,721 - 122,984,472 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248545,067,535 - 5,102,106 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248545,067,578 - 5,106,052 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Stat1
254 total Variants


Assembly: Rnor_6.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
9 54324404 54324405 C T snv SR/JrHsd (RGD), LEW/Crl (RGD) View more Information

Predicted Target Of
Summary Value
Count of predictions:477
Count of miRNA genes:242
Interacting mature miRNAs:295
Transcripts:ENSRNOT00000019465
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 31 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
7411571Bw138Body weight QTL 13814.30.001body mass (VT:0001259)body weight gain (CMO:0000420)93253550577535505Rat
1300180Bw14Body weight QTL 143.776body mass (VT:0001259)body weight (CMO:0000012)92375402461381613Rat
11353957Bmd92Bone mineral density QTL 920.01tibia mineral mass (VT:1000283)volumetric bone mineral density (CMO:0001553)94611419991114199Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70218Cm28Cardiac mass QTL 288.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)92526804479271759Rat
724544Uae9Urinary albumin excretion QTL 94.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)925268044114175309Rat
7207805Bmd88Bone mineral density QTL 884femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)92375402458157242Rat
631643Bp120Blood pressure QTL 12030.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)92207120067071200Rat
12879506Pur33Proteinuria QTL 33urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)94464992189649921Rat
731164Uae25Urinary albumin excretion QTL 253.50.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)925661188100929786Rat

1 to 10 of 31 rows
RH129933  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,420,416 - 49,420,598 (+)MAPPERmRatBN7.2
Rnor_6.0954,288,396 - 54,288,577NCBIRnor6.0
Rnor_5.0953,999,060 - 53,999,241UniSTSRnor5.0
RGSC_v3.4946,456,491 - 46,456,672UniSTSRGSC3.4
Celera947,083,738 - 47,083,919UniSTS
Cytogenetic Map9q31-q32UniSTS
RH141148  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2949,419,630 - 49,419,817 (+)MAPPERmRatBN7.2
Rnor_6.0954,287,610 - 54,287,796NCBIRnor6.0
Rnor_5.0953,998,274 - 53,998,460UniSTSRnor5.0
RGSC_v3.4946,455,705 - 46,455,891UniSTSRGSC3.4
Celera947,082,952 - 47,083,138UniSTS
Cytogenetic Map9q31-q32UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
3 11 43 82 57 60 41 19 41 160 73 74 35 41 19


1 to 17 of 17 rows
RefSeq Transcripts NM_001034164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_032612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA901120 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC094675 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF034252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF053767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF205604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062079 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM386875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF109416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV075250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DY564252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232551 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 17 of 17 rows

Ensembl Acc Id: ENSRNOT00000019465   ⟹   ENSRNOP00000019465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,419,340 - 49,459,978 (-)Ensembl
Rnor_6.0 Ensembl954,287,541 - 54,327,958 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000020032   ⟹   ENSRNOP00000020032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,471,395 - 49,588,540 (-)Ensembl
Rnor_6.0 Ensembl954,340,652 - 54,457,753 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080522   ⟹   ENSRNOP00000070183
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,424,157 - 49,499,445 (-)Ensembl
Rnor_6.0 Ensembl954,292,312 - 54,351,339 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083514   ⟹   ENSRNOP00000070268
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl949,471,395 - 49,588,540 (-)Ensembl
Rnor_6.0 Ensembl954,340,713 - 54,484,533 (-)Ensembl
RefSeq Acc Id: NM_001034164   ⟹   NP_001029336
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,916,986 - 56,951,926 (-)NCBI
mRatBN7.2949,425,026 - 49,459,969 (-)NCBI
Rnor_6.0954,293,004 - 54,327,958 (-)NCBI
Rnor_5.0953,998,204 - 54,038,463 (-)NCBI
RGSC_v3.4946,455,635 - 46,497,560 (-)RGD
Celera947,088,347 - 47,123,002 (-)NCBI
Sequence:
RefSeq Acc Id: NM_032612   ⟹   NP_116001
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8956,911,522 - 56,951,926 (-)NCBI
mRatBN7.2949,419,561 - 49,459,969 (-)NCBI
Rnor_6.0954,287,540 - 54,327,958 (-)NCBI
Rnor_5.0953,998,204 - 54,038,463 (-)NCBI
RGSC_v3.4946,455,635 - 46,497,560 (-)RGD
Celera947,082,882 - 47,123,002 (-)RGD
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_001029336 (Get FASTA)   NCBI Sequence Viewer  
  NP_116001 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC08438 (Get FASTA)   NCBI Sequence Viewer  
  AAF20200 (Get FASTA)   NCBI Sequence Viewer  
  AAH62079 (Get FASTA)   NCBI Sequence Viewer  
  EDL99092 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019465
  ENSRNOP00000019465.7
  ENSRNOP00000070183.2
  ENSRNOP00000070268.2
1 to 10 of 10 rows
RefSeq Acc Id: NP_116001   ⟸   NM_032612
- Peptide Label: isoform alpha
- UniProtKB: Q9QXK0 (UniProtKB/TrEMBL),   A6INW8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029336   ⟸   NM_001034164
- Peptide Label: isoform beta
- UniProtKB: Q6P6Q7 (UniProtKB/TrEMBL),   Q9QXK0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000070183   ⟸   ENSRNOT00000080522
Ensembl Acc Id: ENSRNOP00000019465   ⟸   ENSRNOT00000019465
Ensembl Acc Id: ENSRNOP00000020032   ⟸   ENSRNOT00000020032
SH2

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JX93-F1-model_v2 AlphaFold A0A0G2JX93 1-1083 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13696657
Promoter ID:EPDNEW_R7182
Type:initiation region
Name:Stat1_1
Description:signal transducer and activator of transcription 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R7183  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0954,327,971 - 54,328,031EPDNEW


1 to 40 of 55 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-27607 BioCyc
Ensembl Genes ENSRNOG00000014079 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000019465 ENTREZGENE
  ENSRNOT00000019465.8 UniProtKB/TrEMBL
  ENSRNOT00000080522.2 UniProtKB/TrEMBL
  ENSRNOT00000083514.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  6.10.250.3310 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5599645 IMAGE-MGC_LOAD
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT1_C_sf UniProtKB/TrEMBL
  STAT1_SH2 UniProtKB/TrEMBL
  STAT1_TAZ2-bd_C UniProtKB/TrEMBL
  STAT4 UniProtKB/TrEMBL
  STAT4_CCD UniProtKB/TrEMBL
  STAT4_SH2 UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_core UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_sub UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report rno:25124 UniProtKB/TrEMBL
MGC_CLONE MGC:72374 IMAGE-MGC_LOAD
NCBI Gene 25124 ENTREZGENE
PANTHER STAT UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT1_TAZ2bind UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
1 to 40 of 55 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Stat1  signal transducer and activator of transcription 1      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_function transcription factor that binds to the IFN-stimulated response element (ISRE) and to the GAS element