Sod3 (superoxide dismutase 3) - Rat Genome Database

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Gene: Sod3 (superoxide dismutase 3) Rattus norvegicus
Analyze
Symbol: Sod3
Name: superoxide dismutase 3
RGD ID: 3733
Description: Enables superoxide dismutase activity. Involved in blood vessel diameter maintenance; response to copper ion; and response to oxidative stress. Located in collagen-containing extracellular matrix and extracellular space. Used to study hypertension. Human ortholog(s) of this gene implicated in several diseases, including coronary artery disease (multiple); diabetes mellitus (multiple); diabetic retinopathy; lung disease (multiple); and polyneuropathy. Orthologous to human SOD3 (superoxide dismutase 3); PARTICIPATES IN cardiovascular system disease pathway; diabetes mellitus pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: EC-SOD; ECSODPT; extracellular superoxide dismutase; extracellular superoxide dismutase [Cu-Zn]; Superoxide dimutase 3; superoxide dismutase 3, extracellular; superoxide dismutase B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Sod3m1Mcwi
Genetic Models: SS-Sod3m1Mcwi
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81462,822,865 - 62,828,602 (-)NCBIGRCr8
mRatBN7.21458,610,104 - 58,615,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,609,958 - 58,615,990 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,014,801 - 63,020,544 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01464,328,499 - 64,334,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01460,725,263 - 60,731,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01460,958,583 - 60,971,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1460,958,592 - 60,964,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01461,071,304 - 61,083,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41463,381,447 - 63,387,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11463,383,838 - 63,389,571 (-)NCBI
Celera1457,707,717 - 57,713,440 (-)NCBICelera
Cytogenetic Map14q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Sod3Ratbrain ischemia  ISORGD:113311580852 RGD 
Sod3Ratchronic obstructive pulmonary disease  ISORGD:7365151581270DNA:polymorphism: :p.R213G (human)RGD 
Sod3Ratchronic obstructive pulmonary disease susceptibilityISORGD:7365159068941DNA:polymorphism: :p.R213G (human)RGDPMID:16399992|REF_RGD_ID:1581270
Sod3Ratcoronary artery disease  ISORGD:7365151580853 RGD 
Sod3Ratdiabetes mellitus  ISORGD:7365151581299 RGD 
Sod3RatDiabetic Nephropathies  ISORGD:113312312361protein:decreased expression:kidneyRGD 
Sod3Ratdiabetic retinopathy  ISORGD:7365151581298 RGD 
Sod3RatFibrosis  ISORGD:113311581266 RGD 
Sod3Ratheart disease  ISORGD:7365151580843 RGD 
Sod3Ratheart disease  ISORGD:7365151579965 RGD 
Sod3RatHyperoxia  ISORGD:7365151581277 RGD 
Sod3Rathypertension  ISORGD:113311581232 RGD 
Sod3Rathypertension  IDA 1580845 RGD 
Sod3RatHypertriglyceridemia  ISORGD:736515401827159associated with coronary artery disease;DNA:SNP: :rs2536512, rs2855262 (human)RGD 
Sod3RatHypoxia  ISORGD:113311581265 RGD 
Sod3RatInsulin Resistance  ISORGD:7365151625698associated with Diabetes Mellitus, Type 2;protein:increased expression:plasmaRGD 
Sod3Ratintermediate coronary syndrome  ISORGD:7365151580841 RGD 
Sod3RatLiver Reperfusion Injury treatmentISORGD:7365151581095human gene in a rat modelRGD 
Sod3Ratmyocardial infarction  ISORGD:7365151580841 RGD 
Sod3RatMyocardial Ischemia  IDA 1580843 RGD 
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Sod3RatMyocardial Ischemia  ISORGD:7365158554872ClinVar Annotator: match by term: Superoxide dismutase, elevated extracellularClinVarPMID:14662715|PMID:7662997|PMID:8034674
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Sod3RatChemical and Drug Induced Liver Injury  ISORGD:73651511554173CTD Direct Evidence: therapeuticCTDPMID:11529661
Sod3Ratchronic obstructive pulmonary disease  ISORGD:73651511554173CTD Direct Evidence: marker/mechanismCTDPMID:16399992|PMID:16467073
Sod3Ratcongestive heart failure  ISORGD:73651511554173CTD Direct Evidence: marker/mechanismCTDPMID:20304815
Sod3Ratcontact dermatitis  ISORGD:73651511554173CTD Direct Evidence: therapeuticCTDPMID:17392825
Sod3Ratdiffuse large B-cell lymphoma  ISORGD:73651511554173CTD Direct Evidence: marker/mechanismCTDPMID:16081686
Sod3RatDisease Progression  ISORGD:73651511554173CTD Direct Evidence: marker/mechanismCTDPMID:16081686
Sod3Rathypertension  ISORGD:73651511554173CTD Direct Evidence: marker/mechanism|therapeuticCTDPMID:16864745|PMID:17023265
Sod3RatNecrosis  ISORGD:73651511554173CTD Direct Evidence: therapeuticCTDPMID:11529661
Sod3Ratpulmonary fibrosis  ISORGD:73651511554173CTD Direct Evidence: therapeuticCTDPMID:15298984
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Sod3Rat(+)-catechin multiple interactionsISORGD:7365156480464[Oxygen deficiency co-treated with Catechin] results in decreased expression of SOD3 mRNACTDPMID:35883890
Sod3Rat(-)-epigallocatechin 3-gallate decreases expressionISORGD:7365156480464epigallocatechin gallate results in decreased expression of SOD3 mRNACTDPMID:20706672
Sod3Rat(E)-cinnamyl alcohol increases expressionISORGD:7365156480464cinnamyl alcohol results in increased expression of SOD3 mRNACTDPMID:20566472
Sod3Rat1,1-dichloroethene decreases expressionISORGD:113316480464vinylidene chloride results in decreased expression of SOD3 mRNACTDPMID:26682919
Sod3Rat1,2-dimethylhydrazine decreases expressionEXP 64804641,2-Dimethylhydrazine results in decreased expression of SOD3 mRNACTDPMID:32387197
Sod3Rat1-chloro-2,4-dinitrobenzene increases expressionISORGD:7365156480464Dinitrochlorobenzene results in increased expression of SOD3 mRNACTDPMID:20566472
Sod3Rat17alpha-ethynylestradiol affects expressionISORGD:113316480464Ethinyl Estradiol affects the expression of SOD3 mRNACTDPMID:17555576
Sod3Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of SOD3 mRNACTDPMID:17557909|PMID:29097150
Sod3Rat17alpha-ethynylestradiol multiple interactionsISORGD:113316480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SOD3 mRNACTDPMID:17942748
Sod3Rat17beta-estradiol decreases expressionEXP 6480464Estradiol results in decreased expression of SOD3 mRNA; Estradiol results in decreased expression of SOD3 more ...CTDPMID:23027624|PMID:24894866
Sod3Rat17beta-estradiol decreases expressionISORGD:113316480464Estradiol results in decreased expression of SOD3 mRNACTDPMID:39298647
Sod3Rat17beta-estradiol multiple interactionsISORGD:7365156480464[Estradiol co-treated with TGFB1 protein] results in decreased expression of SOD3 mRNA; Ascorbic Acid inhibits more ...CTDPMID:25130429|PMID:30165855
Sod3Rat17beta-estradiol decreases expressionISORGD:7365156480464Estradiol results in decreased expression of SOD3 mRNA; Estradiol results in decreased expression of SOD3 more ...CTDPMID:25130429|PMID:28960787
Sod3Rat17beta-estradiol decreases activityEXP 6480464Estradiol results in decreased activity of SOD3 proteinCTDPMID:23027624
Sod3Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of SOD3 mRNACTDPMID:12816884|PMID:16195479|PMID:32145629
Sod3Rat17beta-estradiol increases stabilityEXP 6480464Estradiol results in increased stability of SOD3 mRNACTDPMID:12816884
Sod3Rat17beta-estradiol multiple interactionsISORGD:113316480464Estradiol inhibits the reaction [Progesterone results in decreased expression of SOD3 mRNA]CTDPMID:16195479
Sod3Rat17beta-estradiol affects expressionISORGD:113316480464Estradiol affects the expression of SOD3 mRNACTDPMID:16195479
Sod3Rat17beta-estradiol multiple interactionsEXP 6480464Ascorbic Acid inhibits the reaction [Estradiol inhibits the reaction [NFE2L2 protein binds to SOD3 promoter]]; more ...CTDPMID:12816884|PMID:16195479|PMID:23027624|PMID:24894866
Sod3Rat2,2',4,4'-Tetrabromodiphenyl ether increases expressionEXP 64804642,2',4,4'-tetrabromodiphenyl ether results in increased expression of SOD3 mRNACTDPMID:21394737

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Biological Process

  
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Original Reference(s)
Sod3Ratblood vessel diameter maintenance  IMP 38548929 RGD 
Sod3Ratremoval of superoxide radicals involved_inIBAFB:FBgn0033631|MGI:98351|PANTHER:PTN000000113|RGD:3731|UniProtKB:P00441|UniProtKB:P00442|WB:WBGene000049301600115GO_REF:0000033GO_CentralGO_REF:0000033
Sod3Ratresponse to copper ion  IMP 1581097 RGD 
Sod3Ratresponse to hypoxia acts_upstream_of_or_withinISORGD:113311624291MGI:2652386 PMID:15016652RGDPMID:15016652
Sod3Ratresponse to oxidative stress  IEP 1581091 RGD 
Sod3Ratsuperoxide metabolic process involved_inIEAInterPro:IPR001424|InterPro:IPR0364231600115GO_REF:0000002InterProGO_REF:0000002

Cellular Component
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Sod3Ratcollagen-containing extracellular matrix located_inISORGD:7365151624291 PMID:9699963RGDPMID:9699963
Sod3Ratcollagen-containing extracellular matrix located_inISORGD:113311624291 PMID:15528465RGDPMID:15528465
Sod3Ratcytoplasm  IDA 1581086 RGD 
Sod3Ratextracellular matrix  IDA 1581086 RGD 
Sod3Ratextracellular region located_inIEAUniProtKB-SubCell:SL-01121600115GO_REF:0000044UniProtGO_REF:0000044
Sod3Ratextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
Sod3Ratextracellular space  IDA 730025 RGD 
Sod3Ratextracellular space located_inISORGD:113311624291 PMID:15016652RGDPMID:15016652
Sod3RatGolgi apparatus located_inIEAUniProtKB-SubCell:SL-01321600115GO_REF:0000044UniProtGO_REF:0000044
Sod3RatGolgi apparatus located_inIEAUniProtKB-KW:KW-03331600115GO_REF:0000043UniProtGO_REF:0000043
Sod3Ratnucleus  IDA 1581086 RGD 
1 to 11 of 11 rows

Molecular Function
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Original Reference(s)
Sod3Ratantioxidant activity enablesIEAUniProtKB-KW:KW-00491600115GO_REF:0000043UniProtGO_REF:0000043
Sod3Ratcopper ion binding enablesIBACGD:CAL0000184565|CGD:CAL0000188676|PANTHER:PTN000000113|RGD:3731|UniProtKB:O14618|UniProtKB:P00441|UniProtKB:P00442|UniProtKB:P0AGD1|WB:WBGene000049301600115GO_REF:0000033GO_CentralGO_REF:0000033
Sod3Ratcopper ion binding enablesIEAInterPro:IPR0241341600115GO_REF:0000002InterProGO_REF:0000002
Sod3Ratmetal ion binding enablesIEAInterPro:IPR001424|InterPro:IPR0364231600115GO_REF:0000002InterProGO_REF:0000002
Sod3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Sod3Ratmolecular adaptor activity enablesISORGD:7365151624291 PMID:19289127RGDPMID:19289127
Sod3Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Sod3Ratprotein binding enablesISORGD:7365151624291UniProtKB:O43765|UniProtKB:Q04656|UniProtKB:Q12797-6|UniProtKB:Q96EQ0|UniProtKB:Q9NZI2-2|UniProtKB:Q9UBX5|UniProtKB:Q9UHD9|UniProtKB:Q9UMX0|UniProtKB:Q9Y2W7 PMID:15528465, PMID:16371425, PMID:25416956, PMID:32296183RGDPMID:15528465|PMID:16371425|PMID:25416956|PMID:32296183
Sod3Ratprotein binding enablesISORGD:113311624291PR:Q64430 PMID:16371425RGDPMID:16371425
Sod3Ratsuperoxide dismutase activity  IDA 730025 RGD 
Sod3Ratsuperoxide dismutase activity enablesIEAEC:1.15.1.11600115GO_REF:0000003UniProtGO_REF:0000003
Sod3Ratsuperoxide dismutase activity enablesIEARHEA:206961600115GO_REF:0000116RHEAGO_REF:0000116
Sod3Ratsuperoxide dismutase activity enablesISORGD:113311624291 PMID:16371425RGDPMID:16371425
Sod3Ratsuperoxide dismutase activity enablesIBACGD:CAL0000184565|CGD:CAL0000188676|FB:FBgn0003462|FB:FBgn0033631|MGI:103181|MGI:98351|PANTHER:PTN000000113|PomBase:SPAC821.10c|RGD:3731|RGD:3733|SGD:S000003865|TAIR:locus:2025595|TAIR:locus:2046168|UniProtKB:A0A1D8PLJ3|UniProtKB:P00441|UniProtKB:P00442|UniProtKB:P0AGD1|UniProtKB:P9WGE9|WB:WBGene00004930|WB:WBGene00004933|ZFIN:ZDB-GENE-030131-8743|ZFIN:ZDB-GENE-050309-208|ZFIN:ZDB-GENE-990415-258|dictyBase:DDB_G0267420|dictyBase:DDB_G02829931600115GO_REF:0000033GO_CentralGO_REF:0000033
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RGD Manual Annotations


  
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Original Reference(s)
Sod3Ratcardiovascular system disease pathway  ISORGD:7365151579965 RGD 
Sod3Ratdiabetes mellitus pathway  ISORGD:7365151581299 RGD 
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Sod3Ratabnormal vasodilation  IMP 38548929DNA:missense mutation:CDS:p.E124DRGD 
Sod3Ratdecreased superoxide dismutase level  IMP 14369425in lungRGD 
Sod3Ratdecreased superoxide dismutase level onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratdecreased vasodilation  IMP 38548929compared to SS/JrHsdMcwi;DNA:missense mutation:cds:p.E124DRGD 
Sod3Ratglomerulosclerosis onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratheart left ventricle hypertrophy  IMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratincreased circulating creatinine level onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratincreased fluid intake  IMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratincreased food intake  IMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratincreased mean systemic arterial blood pressure onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratincreased systemic arterial diastolic blood pressure onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratincreased systemic arterial systolic blood pressure onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratincreased vasoconstriction  IMP 38548929XCO:0000145;DNA:missense mutation:cds:p.E124DRGD 
Sod3Ratincreased vasodilation  IMP 38548929compared to SS/JrHsdMcwi;DNA:missense mutation:CDS:p.E124DRGD 
Sod3Ratoxidative stress onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratrenal cast onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratrenal fibrosis onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratrenal glomerulus fibrosis onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
Sod3Ratrenal interstitial fibrosis onsetIMP 150573712compared to SS/JrHsdMcwiRGD 
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#
Reference Title
Reference Citation
1. Relationship of plasma extracellular-superoxide dismutase level with insulin resistance in type 2 diabetic patients. Adachi T, etal., J Endocrinol. 2004 Jun;181(3):413-7.
2. Transgenic extracellular superoxide dismutase protects postnatal alveolar epithelial proliferation and development during hyperoxia. Auten RL, etal., Am J Physiol Lung Cell Mol Physiol. 2006 Jan;290(1):L32-40. Epub 2005 Aug 12.
3. Amelioration of salt-induced vascular dysfunction in mesenteric arteries of Dahl salt-sensitive rats by missense mutation of extracellular superoxide dismutase. Beyer AM, etal., Am J Physiol Heart Circ Physiol. 2014 Feb;306(3):H339-47. doi: 10.1152/ajpheart.00619.2012. Epub 2013 Dec 6.
4. Role of extracellular superoxide dismutase in bleomycin-induced pulmonary fibrosis. Bowler RP, etal., Am J Physiol Lung Cell Mol Physiol. 2002 Apr;282(4):L719-26.
5. Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. Bowler RP, etal., J Biol Chem 2002 May 10;277(19):16505-11.
6. The rat extracellular superoxide dismutase dimer is converted to a tetramer by the exchange of a single amino acid. Carlsson LM, etal., Proc Natl Acad Sci U S A 1996 May 28;93(11):5219-22.
7. Altered expression profile of superoxide dismutase isoforms in nasal polyps from nonallergic patients. Cheng YK, etal., Laryngoscope. 2006 Mar;116(3):417-22.
8. Gene transfer of extracellular superoxide dismutase reduces arterial pressure in spontaneously hypertensive rats: role of heparin-binding domain. Chu Y, etal., Circ Res. 2003 Mar 7;92(4):461-8. Epub 2003 Jan 23.
9. Long-term hyperglycaemia decreases vascular fraction of extracellular superoxide dismutase. Ciechanowski K, etal., Diabetologia. 2003 Jul;46(7):1026-7. Epub 2003 Jun 27.
10. Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis. Constantino L, etal., Intensive Care Med Exp. 2014 Dec;2(1):17. doi: 10.1186/2197-425X-2-17. Epub 2014 May 23.
11. Association of genetic polymorphisms in SOD2, SOD3, GPX3, and GSTT1 with hypertriglyceridemia and low HDL-C level in subjects with high risk of coronary artery disease. Decharatchakul N, etal., PeerJ. 2019 Aug 1;7:e7407. doi: 10.7717/peerj.7407. eCollection 2019.
12. Superoxide dismutase responds to hyperoxia in rat hippocampus. Freiberger J, etal., Undersea Hyperb Med. 2004 Summer;31(2):227-32.
13. Reduction of renal superoxide dismutase in progressive diabetic nephropathy. Fujita H, etal., J Am Soc Nephrol. 2009 Jun;20(6):1303-13. Epub 2009 May 21.
14. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
15. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
16. Role of extracellular superoxide dismutase in hypertension. Gongora MC, etal., Hypertension. 2006 Sep;48(3):473-81. Epub 2006 Jul 24.
17. Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3. Guo H, etal., Free Radic Biol Med. 2020 May 20;152:787-796. doi: 10.1016/j.freeradbiomed.2020.01.023. Epub 2020 Jan 21.
18. Upregulation of vascular extracellular superoxide dismutase in patients with acute coronary syndromes. Horiuchi M, etal., Arterioscler Thromb Vasc Biol. 2004 Jan;24(1):106-11. Epub 2003 Oct 30.
19. Gene transfer of extracellular superoxide dismutase improves endothelial function in rats with heart failure. Iida S, etal., Am J Physiol Heart Circ Physiol. 2005 Aug;289(2):H525-32.
20. Vascular effects of a common gene variant of extracellular superoxide dismutase in heart failure. Iida S, etal., Am J Physiol Heart Circ Physiol. 2006 Aug;291(2):H914-20.
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PMID:9699963   PMID:15016652   PMID:15489334   PMID:15528465   PMID:16371425   PMID:17196988   PMID:19198181   PMID:19495415   PMID:20033309   PMID:20551380   PMID:21736484   PMID:21909393  
PMID:22540739   PMID:23376485   PMID:23533145   PMID:24006456   PMID:27068509   PMID:27559042   PMID:31714656   PMID:36251410   PMID:36989187  



Sod3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81462,822,865 - 62,828,602 (-)NCBIGRCr8
mRatBN7.21458,610,104 - 58,615,845 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1458,609,958 - 58,615,990 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1463,014,801 - 63,020,544 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01464,328,499 - 64,334,244 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01460,725,263 - 60,731,010 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01460,958,583 - 60,971,143 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1460,958,592 - 60,964,324 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01461,071,304 - 61,083,776 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41463,381,447 - 63,387,180 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11463,383,838 - 63,389,571 (-)NCBI
Celera1457,707,717 - 57,713,440 (-)NCBICelera
Cytogenetic Map14q11NCBI
SOD3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38424,795,573 - 24,800,842 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl424,789,912 - 24,800,842 (+)EnsemblGRCh38hg38GRCh38
GRCh37424,797,195 - 24,802,464 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36424,406,183 - 24,411,565 (+)NCBINCBI36Build 36hg18NCBI36
Build 34424,472,323 - 24,478,733NCBI
Celera425,246,551 - 25,251,936 (+)NCBICelera
Cytogenetic Map4p15.2NCBI
HuRef424,139,594 - 24,144,972 (+)NCBIHuRef
CHM1_1424,796,442 - 24,801,824 (+)NCBICHM1_1
T2T-CHM13v2.0424,777,502 - 24,782,774 (+)NCBIT2T-CHM13v2.0
Sod3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39552,521,146 - 52,527,080 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl552,521,133 - 52,528,760 (+)EnsemblGRCm39 Ensembl
GRCm38552,363,804 - 52,369,738 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl552,363,791 - 52,371,418 (+)EnsemblGRCm38mm10GRCm38
MGSCv37552,755,043 - 52,760,977 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36552,652,052 - 52,657,986 (+)NCBIMGSCv36mm8
Celera549,732,370 - 49,738,292 (+)NCBICelera
Cytogenetic Map5C1NCBI
cM Map527.92NCBI
Sod3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955480257,716 - 263,149 (-)NCBIChiLan1.0ChiLan1.0
SOD3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2325,042,416 - 25,047,841 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1425,239,089 - 25,248,284 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0419,195,941 - 19,201,298 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1424,480,912 - 24,486,382 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl424,485,059 - 24,485,781 (+)Ensemblpanpan1.1panPan2
SOD3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1385,382,698 - 85,387,144 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl385,382,484 - 85,387,455 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha387,896,595 - 87,901,009 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0386,357,866 - 86,362,385 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl386,357,992 - 86,359,248 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1385,490,694 - 85,495,210 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0385,596,388 - 85,600,748 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0385,980,631 - 85,986,057 (-)NCBIUU_Cfam_GSD_1.0
SOD3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl818,796,637 - 18,802,152 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1818,796,633 - 18,802,156 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2819,293,239 - 19,293,972 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12725,554,474 - 25,559,873 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2725,555,082 - 25,555,804 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604772,074,072 - 72,079,449 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247557,535,044 - 7,541,221 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247557,535,044 - 7,541,298 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Sod3
10 total Variants

Predicted Target Of
Summary Value
Count of predictions:287
Count of miRNA genes:163
Interacting mature miRNAs:180
Transcripts:ENSRNOT00000005155
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 21 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2313089Bss81Bone structure and strength QTL 813.40.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)143766971982669719Rat
1581500Renag1Renal agenesis QTL 1kidney development trait (VT:0000527)percentage of study population developing unilateral renal agenesis during a period of time (CMO:0000940)14817066868298175Rat
9590294Uminl4Urine mineral level QTL 45.660.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)1455624247100624247Rat
2300197Scl59Serum cholesterol level QTL 59blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)1455147478100147478Rat
10755459Coatc15Coat color QTL 150.01681coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)141983694464836944Rat
70214Niddm28Non-insulin dependent diabetes mellitus QTL 284.06blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)143999825175582726Rat
1300154Bp189Blood pressure QTL 1893.04arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)143088377768757901Rat
70187Pancm5Pancreatic morphology QTL 516.7pancreas mass (VT:0010144)pancreas weight to body weight ratio (CMO:0000630)143032009280829842Rat
631523Pia13Pristane induced arthritis QTL 133.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)144079346098037301Rat
2313100Bss82Bone structure and strength QTL 8230.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143766971982669719Rat

1 to 10 of 21 rows

This gene Sod3 is modified in the following models/strains:
SS-Sod3m1Mcwi    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000005155   ⟹   ENSRNOP00000005155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1458,609,958 - 58,615,990 (-)Ensembl
Rnor_6.0 Ensembl1460,958,592 - 60,964,324 (-)Ensembl
RefSeq Acc Id: NM_012880   ⟹   NP_037012
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81462,822,865 - 62,828,602 (-)NCBI
mRatBN7.21458,610,104 - 58,615,845 (-)NCBI
Rnor_6.01460,958,591 - 60,964,324 (-)NCBI
Rnor_5.01461,071,304 - 61,083,776 (-)NCBI
RGSC_v3.41463,381,447 - 63,387,180 (-)RGD
Celera1457,707,717 - 57,713,440 (-)RGD
Sequence:
1 to 10 of 10 rows
Protein RefSeqs NP_037012 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61861 (Get FASTA)   NCBI Sequence Viewer  
  CAA48177 (Get FASTA)   NCBI Sequence Viewer  
  CAA64149 (Get FASTA)   NCBI Sequence Viewer  
  CAA80849 (Get FASTA)   NCBI Sequence Viewer  
  CAB58912 (Get FASTA)   NCBI Sequence Viewer  
  EDL99891 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000005155.2
  ENSRNOP00000101578
GenBank Protein Q08420 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_037012   ⟸   NM_012880
- Peptide Label: precursor
- UniProtKB: Q64667 (UniProtKB/Swiss-Prot),   Q08420 (UniProtKB/Swiss-Prot),   A6IJH8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000005155   ⟸   ENSRNOT00000005155
Superoxide dismutase copper/zinc binding

Name Modeler Protein Id AA Range Protein Structure
AF-Q08420-F1-model_v2 AlphaFold Q08420 1-244 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13699337
Promoter ID:EPDNEW_R9862
Type:initiation region
Name:Sod3_1
Description:superoxide dismutase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01460,964,292 - 60,964,352EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-15590 BioCyc
BioCyc Pathway DETOX1-PWY [superoxide radicals degradation] BioCyc
  DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
BioCyc Pathway Image DETOX1-PWY BioCyc
  DETOX1-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000003869 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005155.4 UniProtKB/Swiss-Prot
  ENSRNOT00000158055 ENTREZGENE
Gene3D-CATH 2.60.40.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598594 IMAGE-MGC_LOAD
InterPro SOD-like_Cu/Zn_dom_sf UniProtKB/Swiss-Prot
  SOD_Cu/Zn_/chaperone UniProtKB/Swiss-Prot
  SOD_Cu/Zn_BS UniProtKB/Swiss-Prot
  SOD_Cu_Zn_dom UniProtKB/Swiss-Prot
KEGG Report rno:25352 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72515 IMAGE-MGC_LOAD
NCBI Gene 25352 ENTREZGENE
PANTHER PTHR10003 UniProtKB/Swiss-Prot
Pfam Sod_Cu UniProtKB/Swiss-Prot
PhenoGen Sod3 PhenoGen
PRINTS CUZNDISMTASE UniProtKB/Swiss-Prot
PROSITE SOD_CU_ZN_1 UniProtKB/Swiss-Prot
  SOD_CU_ZN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000003869 RatGTEx
Superfamily-SCOP SSF49329 UniProtKB/Swiss-Prot
TIGR TC218284
UniProt A6IJH8 ENTREZGENE, UniProtKB/TrEMBL
  Q08420 ENTREZGENE
  Q64667 ENTREZGENE
  SODE_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q64667 UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-24 Sod3  superoxide dismutase 3  Sod3  superoxide dismutase 3, extracellular  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Sod3  superoxide dismutase 3, extracellular    superoxide dismutase 3  Name updated 1299863 APPROVED
2003-04-09 Sod3  superoxide dismutase 3    Superoxide dismutase 3  Name updated 629478 APPROVED
2001-12-21 Sod3  Superoxide dismutase 3      Name updated 69729 APPROVED

Note Type Note Reference
gene_expression expressed in epididymis 730184
gene_homology presence of Asp28 is associated with dimerization of the rat protein rather than tetramer formation observed in mice and human homologs, which contain Val28 730025
gene_mutations_overexpression D28V mutant forms a tetramer and has high affinity for heparin sulfate 730025
gene_physical_interaction binds to heparin 730119
gene_process may be involved in preserving spermatozoa fertility by preventing lipid peroxidation 730184
gene_protein forms a dimer; a copper-zinc containing glycoprotein 730025