Sod1 (superoxide dismutase 1) - Rat Genome Database

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Gene: Sod1 (superoxide dismutase 1) Rattus norvegicus
Analyze
Symbol: Sod1
Name: superoxide dismutase 1
RGD ID: 3731
Description: Enables copper ion binding activity; protein phosphatase 2B binding activity; and superoxide dismutase activity. Involved in several processes, including hydrogen peroxide biosynthetic process; removal of superoxide radicals; and response to antipsychotic drug. Located in several cellular components, including dense core granule; neuronal cell body; and peroxisome. Part of protein-containing complex. Used to study hyperthyroidism; hypothyroidism; middle cerebral artery infarction; and sciatic neuropathy. Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); congenital diaphragmatic hernia; metabolic dysfunction-associated steatohepatitis; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; artery disease (multiple); eye disease (multiple); glucose metabolism disease (multiple); and neurodegenerative disease (multiple). Orthologous to human SOD1 (superoxide dismutase 1); PARTICIPATES IN hypertension pathway; amyotrophic lateral sclerosis pathway; forkhead class A signaling pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (-)-cotinine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CuZnSOD; Superoxide dimutase 1 soluble; superoxide dismutase; Superoxide dismutase 1 soluble; superoxide dismutase 1, soluble; superoxide dismutase [Cu-Zn]
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,942,742 - 42,948,399 (+)NCBIGRCr8
mRatBN7.21129,456,673 - 29,462,249 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,456,558 - 29,462,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,144,681 - 38,150,257 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01130,816,072 - 30,821,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,005,455 - 30,011,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,363,282 - 30,368,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,982,764 - 33,988,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,810,766 - 29,816,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11129,810,765 - 29,816,342 (-)NCBI
Celera1129,143,740 - 29,149,316 (+)NCBICelera
Cytogenetic Map11q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Sod1Ratalcohol use disorder  IEP 405255664associated with diabetes more ...RGD 
Sod1RatAlcoholic Liver Diseases treatmentISOSOD1 (Homo sapiens)9587792human gene in a rat modelRGD 
Sod1RatAlzheimer's disease  IEP 8657017mRNA:altered expression:hippocampus and hypothalamus (rat)RGD 
Sod1RatAlzheimer's disease  ISOSod1 (Mus musculus)8655610 RGD 
Sod1RatAlzheimer's disease  ISOSOD1 (Homo sapiens)8655610protein:decreased expression:frontal lobe (human)RGD 
Sod1Ratamyotrophic lateral sclerosis  ISOSOD1 (Homo sapiens)2312367human gene in a rat model and DNA:missense mutation:cds:p.G93A (human)RGD 
Sod1Ratamyotrophic lateral sclerosis  ISOSOD1 (Homo sapiens)8655880protein:increased expression:cerebrospinal fluid (human)RGD 
Sod1Ratamyotrophic lateral sclerosis treatmentISOSOD1 (Homo sapiens)13524551 RGD 
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)737689DNA:missense mutations:cds:multiple (human)RGD 
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8655873DNA:missense mutation:cds:p.D90A (human)RGD 
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8655618DNA:missense mutation:cds:p.I113T (human)RGD 
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8655862DNA:missense mutations:cds:multiple (human)RGD 
Sod1RatAnimal Mammary Neoplasms  IEP 8657018protein:decreased expression:mammary gland (rat)RGD 
Sod1RatAortic Calcification  IEP 11038653associated with Renal Insufficiency more ...RGD 
Sod1Ratatherosclerosis severityISOSod1 (Mus musculus)8655856mRNA:decreased expression:thoracic aorta (mouse)RGD 
Sod1Ratatrial fibrillation  ISOSOD1 (Homo sapiens)8655869associated with Mitral Valve Insufficiency more ...RGD 
Sod1RatBehcet's disease  ISOSOD1 (Homo sapiens)1580846protein:increased activity:serum (human)RGD 
Sod1RatBrain Injuries  ISOSod1 (Mus musculus)1581214 RGD 
Sod1Ratcardiac arrest  ISOSod1 (Mus musculus)1581221 RGD 
Sod1Ratcardiomyopathy  ISOSod1 (Mus musculus)1581220 RGD 
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Sod1Ratamyotrophic lateral sclerosis  ISOSOD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10439968 more ...
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:32729724 more ...
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10321246 more ...
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:32948071 more ...
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10321246 more ...
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:32729725 more ...
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:9455977 more ...
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10321246 more ...
Sod1Ratamyotrophic lateral sclerosis type 10  ISOSOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: AMYOTROPHIC LATERAL SCLEROSIS 10 WITH OR WITHOUT FRONTOTEMPORAL DEMENTIAClinVarPMID:14506936 more ...
Sod1Ratautosomal dominant intellectual developmental disorder 7  ISOSOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: DYRK1A-related intellectual disability syndromeClinVarPMID:17237124 more ...
Sod1RatFamilial Platelet Disorder with Associated Myeloid Malignancy  ISOSOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary thrombocytopenia and hematological cancer predisposition syndrome associated with RUNX1ClinVarPMID:17237124 more ...
Sod1Ratgenetic disease  ISOSOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:14506936 more ...
Sod1Ratimmunodeficiency 28  ISOSOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Immunodeficiency 28ClinVarPMID:17237124 more ...
Sod1Ratmotor neuron disease  ISOSOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Motor neuron diseaseClinVarPMID:10400992 more ...
Sod1RatParkinson's disease 20  ISOSOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Early-onset Parkinson disease 20ClinVarPMID:28492532
Sod1RatSPASTIC TETRAPLEGIA AND AXIAL HYPOTONIA, PROGRESSIVE  ISOSOD1 (Homo sapiens)8554872ClinVar Annotator: match by term: Spastic tetraplegia and axial hypotonia and progressiveClinVarPMID:10400992 more ...
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Sod1Ratacute kidney failure  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28885000
Sod1Ratamyotrophic lateral sclerosis  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7887412 more ...
Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8967745 more ...
Sod1RatAnimal Disease Models  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12586733 more ...
Sod1Rataortic disease  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25101153
Sod1Ratasphyxia neonatorum  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17963755
Sod1Ratasthma  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22867017
Sod1Ratatherosclerosis  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20720404
Sod1Ratbrain ischemia  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:11756504
Sod1RatChemical and Drug Induced Liver Injury  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750 and PMID:27349771
Sod1RatChronic Hepatitis  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25053573
Sod1Ratchronic progressive external ophthalmoplegia  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11907800
Sod1Ratcongestive heart failure  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20304815
Sod1Ratcontact dermatitis  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Sod1Ratdepressive disorder  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19605942
Sod1Ratdevelopmental coordination disorder  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29434186
Sod1Ratdiabetes mellitus  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23786522
Sod1Ratdiabetic retinopathy  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:19074809
Sod1RatDisease Progression  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29434186
Sod1RatDown syndrome  ISOSOD1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11181815
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Sod1Ratamyotrophic lateral sclerosis type 1  ISSSod1 (Mus musculus)13592920OMIM:105400MouseDO 
Sod1Ratdry eye syndrome  ISSSod1 (Mus musculus)13592920 MouseDO 
Sod1Ratlow tension glaucoma  ISSSod1 (Mus musculus)13592920OMIM:606657MouseDO 
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Sod1Ratspinal cord disease  ISOSOD1 (Canis lupus familiaris)9068941Degenerative myelopathyOMIAPMID:12592926 more ...
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Sod1Ratamyotrophic lateral sclerosis type 1  ISOSOD1 (Homo sapiens)7240710 OMIM 
Sod1RatSPASTIC TETRAPLEGIA AND AXIAL HYPOTONIA, PROGRESSIVE  ISOSOD1 (Homo sapiens)7240710 OMIM 

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Sod1Rat(+)-beta-thujone multiple interactionsISOSOD1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SOD1 mRNACTDPMID:38000518
Sod1Rat(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [Rotenone results in decreased activity of SOD1 protein]CTDPMID:35337893
Sod1Rat(+)-isoborneol multiple interactionsISOSod1 (Mus musculus)6480464isoborneol inhibits the reaction [Ceruletide results in decreased expression of SOD1 protein]CTDPMID:33166053
Sod1Rat(+)-schisandrin B multiple interactionsISOSOD1 (Homo sapiens)6480464[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of SOD1 mRNA and NFE2L2 mutant form inhibits the reaction [[Benzo(a)pyrene co-treated with schizandrin B] results in increased expression of SOD1 mRNA]CTDPMID:25946486
Sod1Rat(+)-taxifolin multiple interactionsEXP 6480464taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 mRNA] and taxifolin inhibits the reaction [Dibutyl Phthalate results in decreased expression of SOD1 protein]CTDPMID:32525071
Sod1Rat(-)-cotinine multiple interactionsEXP 6480464[Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 mRNA and [Nicotine results in increased abundance of Cotinine] which results in increased expression of SOD1 proteinCTDPMID:29617909
Sod1Rat(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[1-Methyl-4-phenylpyridinium co-treated with epigallocatechin gallate] results in increased expression of SOD1 mRNA and epigallocatechin gallate inhibits the reaction [Acrylamide results in decreased activity of SOD1 protein]CTDPMID:22742579 and PMID:28056603
Sod1Rat(-)-epigallocatechin 3-gallate decreases expressionISOSOD1 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of SOD1 proteinCTDPMID:35218280
Sod1Rat(-)-epigallocatechin 3-gallate decreases expressionISOSod1 (Mus musculus)6480464epigallocatechin gallate results in decreased expression of SOD1 mRNACTDPMID:25585349
Sod1Rat(E)-cinnamyl alcohol increases expressionISOSOD1 (Homo sapiens)6480464cinnamyl alcohol results in increased expression of SOD1 mRNACTDPMID:20566472
Sod1Rat(E)-thiamethoxam decreases expressionEXP 6480464Thiamethoxam results in decreased expression of SOD1 mRNACTDPMID:36958429
Sod1Rat(E)-thiamethoxam decreases activityEXP 6480464Thiamethoxam results in decreased activity of SOD1 proteinCTDPMID:30621503
Sod1Rat(E)-thiamethoxam multiple interactionsEXP 6480464[fenugreek seed meal results in increased abundance of Polysaccharides] inhibits the reaction [Thiamethoxam results in decreased activity of SOD1 protein] and Silymarin inhibits the reaction [Thiamethoxam results in decreased expression of SOD1 mRNA]CTDPMID:30621503 and PMID:36958429
Sod1Rat(R)-adrenaline multiple interactionsISOSOD1 (Homo sapiens)64804646-hydroxy-2 more ...CTDPMID:11163531
Sod1Rat(R)-adrenaline affects bindingISOSOD1 (Homo sapiens)6480464Epinephrine binds to SOD1 protein mutant formCTDPMID:23612299
Sod1Rat(R)-adrenaline multiple interactionsEXP 6480464[Epinephrine co-treated with Xanthine co-treated with XDH] results in increased expression of SOD1 proteinCTDPMID:19464573
Sod1Rat(R)-adrenaline increases expressionEXP 6480464Epinephrine results in increased expression of SOD1 proteinCTDPMID:19464573
Sod1Rat(R)-adrenaline increases activityISOSOD1 (Homo sapiens)6480464Epinephrine results in increased activity of SOD1 proteinCTDPMID:11163531
Sod1Rat(R)-adrenaline increases expressionISOSOD1 (Homo sapiens)6480464Epinephrine results in increased expression of SOD1 mRNA and Epinephrine results in increased expression of SOD1 proteinCTDPMID:11163531
Sod1Rat(R)-camphor multiple interactionsISOSOD1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SOD1 mRNACTDPMID:38000518

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Biological Process
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Sod1Rataction potential initiation acts_upstream_of_or_withinIEAUniProtKB:P08228 and ensembl:ENSMUSP000000237071600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Rataction potential initiation acts_upstream_of_or_withinISOSod1 (Mus musculus)1624291 PMID:30952836RGDPMID:30952836
Sod1Ratanterograde axonal transport involved_inISOSod1 (Mus musculus)1624291 PMID:20510358RGDPMID:20510358
Sod1Ratanterograde axonal transport involved_inIEAUniProtKB:P08228 and ensembl:ENSMUSP000000237071600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratapoptotic process acts_upstream_ofIEAUniProtKB:P08228 and ensembl:ENSMUSP000000237071600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratapoptotic process acts_upstream_ofISOSod1 (Mus musculus)1624291MGI:1857873 PMID:16036348RGDPMID:16036348
Sod1Ratauditory receptor cell stereocilium organization involved_inISSUniProtKB:P082281600115GO_REF:0000024UniProtGO_REF:0000024
Sod1Ratauditory receptor cell stereocilium organization acts_upstream_of_or_withinIEAUniProtKB:P08228 and ensembl:ENSMUSP000000237071600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratauditory receptor cell stereocilium organization acts_upstream_of_or_withinISOSod1 (Mus musculus)1624291MGI:1857872 PMID:10464373 and PMID:10466888RGDPMID:10464373 and PMID:10466888
Sod1Ratcellular response to ATP  IEP 8655973 RGD 
Sod1Ratcellular response to cadmium ion  IEP 8655656 RGD 
Sod1Ratcellular response to oxidative stress  IEP 8655975 RGD 
Sod1Ratcellular response to potassium ion  IEP 8657024 RGD 
Sod1Ratdetermination of adult lifespan acts_upstream_of_or_withinISOSod1 (Mus musculus)1624291MGI:1857872 PMID:16377630RGDPMID:16377630
Sod1Ratdetermination of adult lifespan acts_upstream_of_or_withinIEAUniProtKB:P08228 and ensembl:ENSMUSP000000237071600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratectopic germ cell programmed cell death acts_upstream_ofIEAUniProtKB:P08228 and ensembl:ENSMUSP000000237071600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratectopic germ cell programmed cell death acts_upstream_ofISOSod1 (Mus musculus)1624291MGI:1857873 PMID:16036348RGDPMID:16036348
Sod1Ratembryo implantation involved_inISSUniProtKB:P082281600115GO_REF:0000024UniProtGO_REF:0000024
Sod1Ratembryo implantation acts_upstream_of_or_withinISOSod1 (Mus musculus)1624291MGI:3526701 PMID:9516486RGDPMID:9516486
Sod1Ratembryo implantation acts_upstream_of_or_withinIEAUniProtKB:P08228 and ensembl:ENSMUSP000000237071600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Sod1Rataxon cytoplasm located_inIEAGO:00080891600115GO_REF:0000108GOCGO_REF:0000108
Sod1Rataxon cytoplasm located_inIEAGO:00080901600115GO_REF:0000108GOCGO_REF:0000108
Sod1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Sod1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Sod1Ratcytoplasm located_inIEAUniProtKB:P00441 and ensembl:ENSP000002701421600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratcytoplasm located_inISOSOD1 (Homo sapiens)1624291 PMID:11527942 more ...RGDPMID:11527942 more ...
Sod1Ratcytoplasm located_inISSUniProtKB:P004411600115GO_REF:0000024UniProtGO_REF:0000024
Sod1Ratcytoplasmic vesicle located_inIEAUniProtKB:P00441 and ensembl:ENSP000002701421600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratcytoplasmic vesicle located_inISOSOD1 (Homo sapiens)1624291 PMID:17077646RGDPMID:17077646
Sod1Ratcytoplasmic vesicle located_inISSUniProtKB:P004411600115GO_REF:0000024UniProtGO_REF:0000024
Sod1Ratcytosol located_inIEAUniProtKB:P00441 and ensembl:ENSP000002701421600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratcytosol is_active_inIBAPANTHER:PTN002558033 and UniProtKB:P004411600115GO_REF:0000033GO_CentralGO_REF:0000033
Sod1Ratcytosol located_inISSUniProtKB:P004411600115GO_REF:0000024UniProtGO_REF:0000024
Sod1Ratcytosol located_inISOSOD1 (Homo sapiens)1624291 PMID:16790527RGDGO_REF:0000052 and PMID:16790527
Sod1Ratcytosol located_inIEAUniProtKB:V9HWC9 and ensembl:ENSP000002701421600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratdendrite cytoplasm located_inISOSOD1 (Homo sapiens)1624291 PMID:17324120RGDPMID:17324120
Sod1Ratdendrite cytoplasm located_inIEAUniProtKB:P00441 and ensembl:ENSP000002701421600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratdendrite cytoplasm located_inISSUniProtKB:P004411600115GO_REF:0000024UniProtGO_REF:0000024
Sod1Ratdense core granule  IDA 8657024 RGD 
Sod1Ratextracellular region  IDA 8655973 RGD 
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Molecular Function
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Sod1Ratantioxidant activity enablesIEAUniProtKB-KW:KW-00491600115GO_REF:0000043UniProtGO_REF:0000043
Sod1Ratcopper ion binding  IMP 634854 RGD 
Sod1Ratcopper ion binding  TAS 1358244 RGD 
Sod1Ratcopper ion binding enablesIBACGD:CAL0000184565 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Sod1Ratcopper ion binding enablesIEAInterPro:IPR0241341600115GO_REF:0000002InterProGO_REF:0000002
Sod1Ratcopper ion binding enablesIEAUniProtKB:P00441 and ensembl:ENSP000002701421600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratcopper ion binding enablesISSUniProtKB:P004411600115GO_REF:0000024UniProtGO_REF:0000024
Sod1Ratcopper ion binding enablesISOSOD1 (Homo sapiens)1624291 PMID:17008312RGDPMID:17008312
Sod1Ratenzyme binding  IPIP4hb (Rattus norvegicus)8655994 RGD 
Sod1Ratidentical protein binding enablesISOSOD1 (Homo sapiens)1624291UniProtKB:P00441 more ...RGDPMID:17592131 more ...
Sod1Ratidentical protein binding enablesIEAUniProtKB:P00441 and ensembl:ENSP000002701421600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratmetal ion binding enablesIEAInterPro:IPR001424 and InterPro:IPR0364231600115GO_REF:0000002InterProGO_REF:0000002
Sod1Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Sod1Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Sod1Ratprotein binding enablesISOSOD1 (Homo sapiens)1624291UniProtKB:A4FUJ8 more ...RGDPMID:12968035 more ...
Sod1Ratprotein binding enablesISOSod1 (Mus musculus)1624291UniProtKB:O55042 more ...RGDPMID:18219391 more ...
Sod1Ratprotein homodimerization activity enablesIEAUniProtKB:P00441 and ensembl:ENSP000002701421600115GO_REF:0000107EnsemblGO_REF:0000107
Sod1Ratprotein homodimerization activity enablesISOSOD1 (Homo sapiens)1624291UniProtKB:P00441 and PMID:24567322RGDPMID:24567322
Sod1Ratprotein phosphatase 2B binding  IDA 8554684 RGD 
Sod1Ratprotein phosphatase 2B binding enablesISOSOD1 (Homo sapiens)1624291 PMID:17324120RGDPMID:17324120
1 to 20 of 42 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod1Ratamyotrophic lateral sclerosis pathway  ISOSod1 (Mus musculus)1581209 RGD 
Sod1Ratamyotrophic lateral sclerosis pathway  ISOSOD1 (Homo sapiens)737689 RGD 
Sod1Rathypertension pathway  IDA 1580833 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod1Ratamyotrophic lateral sclerosis pathway  IEArno:050306907045 KEGGrno:05014
Sod1RatHuntington's disease pathway   IEA 6907045 KEGGrno:05016
Sod1Ratprion disease pathway  IEA 6907045 KEGGrno:05020

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Sod1Ratforkhead class A signaling pathway  ISOSOD1 (Homo sapiens)6484113 PIDPID:200226

1 to 20 of 142 rows
#
Reference Title
Reference Citation
1. Clinical characteristics of familial amyotrophic lateral sclerosis with Cu/Zn superoxide dismutase gene mutations. Abe K, etal., J Neurol Sci. 1996 Mar;136(1-2):108-16.
2. Activation of brain calcineurin (Cn) by Cu-Zn superoxide dismutase (SOD1) depends on direct SOD1-Cn protein interactions occurring in vitro and in vivo. Agbas A, etal., Biochem J. 2007 Jul 1;405(1):51-9.
3. Inflammatory cytokines and reactive oxygen species as mediators of chronic kidney disease-related vascular calcification. Agharazii M, etal., Am J Hypertens. 2015 Jun;28(6):746-55. doi: 10.1093/ajh/hpu225. Epub 2014 Nov 27.
4. Sod1 deficiency reduces incubation time in mouse models of prion disease. Akhtar S, etal., PLoS One. 2013;8(1):e54454. doi: 10.1371/journal.pone.0054454. Epub 2013 Jan 22.
5. Multiple superoxide dismutase 1/splicing factor serine alanine 15 variants are associated with the development and progression of diabetic nephropathy: the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Genetics study. Al-Kateb H, etal., Diabetes. 2008 Jan;57(1):218-28. Epub 2007 Oct 3.
6. Role of superoxide radical anion in the mechanism of apoB100 degradation induced by DHA in hepatic cells. Andreo U, etal., FASEB J. 2011 Oct;25(10):3554-60. doi: 10.1096/fj.11-182725. Epub 2011 Jul 14.
7. Possible role of increased oxidative stress in pulmonary hypertension in experimental diaphragmatic hernia. Aras-Lopez R, etal., Pediatr Surg Int. 2016 Feb;32(2):141-5. doi: 10.1007/s00383-015-3826-5. Epub 2015 Nov 3.
8. Postischemic recovery of contractile function is impaired in SOD2(+/-) but not SOD1(+/-) mouse hearts. Asimakis GK, etal., Circulation. 2002 Feb 26;105(8):981-6.
9. Changes in copper metabolism in different compartments of the brain in rats with induced fibrillogenesis. Babich PS, etal., Bull Exp Biol Med. 2009 Aug;148(2):217-22.
10. Protective effects of atypical antipsychotic drugs on PC12 cells after serum withdrawal. Bai O, etal., J Neurosci Res. 2002 Jul 15;69(2):278-83.
11. 1-methyl-4-phenylpyridinium neurotoxicity is attenuated by adenoviral gene transfer of human Cu/Zn superoxide dismutase. Barkats M, etal., J Neurosci Res. 2006 Feb 1;83(2):233-42.
12. Enhanced neuroinflammation and pain hypersensitivity after peripheral nerve injury in rats expressing mutated superoxide dismutase 1. Berger JV, etal., J Neuroinflammation. 2011 Apr 13;8:33. doi: 10.1186/1742-2094-8-33.
13. Retinal ion regulation in a mouse model of diabetic retinopathy: natural history and the effect of Cu/Zn superoxide dismutase overexpression. Berkowitz BA, etal., Invest Ophthalmol Vis Sci. 2009 May;50(5):2351-8. doi: 10.1167/iovs.08-2918. Epub 2008 Dec 13.
14. Copper deficiency induces the upregulation of the copper chaperone for Cu/Zn superoxide dismutase in weanling male rats. Bertinato J, etal., J Nutr 2003 Jan;133(1):28-31.
15. Peroxiredoxin 2 overexpression protects cortical neuronal cultures from ischemic and oxidative injury but not glutamate excitotoxicity, whereas Cu/Zn superoxide dismutase 1 overexpression protects only against oxidative injury. Boulos S, etal., J Neurosci Res. 2007 Nov 1;85(14):3089-97.
16. Expression and activity of antioxidants in the brain in progressive supranuclear palsy. Cantuti-Castelvetri I, etal., Brain Res. 2002 Mar 15;930(1-2):170-81.
17. SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis. Carlstrom M, etal., Am J Physiol Regul Integr Comp Physiol. 2009 Jul;297(1):R82-92. Epub 2009 Apr 29.
18. Reduction in molecular synthesis or enzyme activity of superoxide dismutases and catalase contributes to oxidative stress and neurogenic hypertension in spontaneously hypertensive rats. Chan SH, etal., Free Radic Biol Med. 2006 Jun 1;40(11):2028-39. Epub 2006 Feb 21.
19. Transcriptional regulation and environmental induction of gene encoding copper- and zinc-containing superoxide dismutase. Chang MS, etal., Methods Enzymol 2002;349:293-305.
20. Inadequate cytoplasmic antioxidant enzymes response contributes to the oxidative stress in human hypertension. Chaves FJ, etal., Am J Hypertens. 2007 Jan;20(1):62-9.
1 to 20 of 142 rows
1 to 10 of 14 rows
PMID:291939   PMID:1332049   PMID:1379810   PMID:3790250   PMID:7172448   PMID:7444718   PMID:8224914   PMID:8673102   PMID:8837775   PMID:9453566   PMID:9516486   PMID:9539776  
PMID:9699963   PMID:9724058   PMID:9726962   PMID:9788901   PMID:10433959   PMID:10466888   PMID:10471451   PMID:10679476   PMID:11343650   PMID:11404260   PMID:11493445   PMID:11527942  
PMID:12223545   PMID:12433839   PMID:12551919   PMID:12646716   PMID:12871978   PMID:12921788   PMID:12968068   PMID:14575298   PMID:14651853   PMID:14679182   PMID:15317809   PMID:15372991  
PMID:15473258   PMID:15489334   PMID:15544046   PMID:15618443   PMID:15634772   PMID:15642323   PMID:16036348   PMID:16084734   PMID:16195234   PMID:16238459   PMID:16357131   PMID:16377630  
PMID:16567040   PMID:16631605   PMID:16688932   PMID:16716900   PMID:16770742   PMID:16790527   PMID:16831125   PMID:16854843   PMID:16942767   PMID:17008312   PMID:17059387   PMID:17077646  
PMID:17196988   PMID:17215005   PMID:17381088   PMID:17448893   PMID:17457363   PMID:17463094   PMID:17485834   PMID:17485853   PMID:17504823   PMID:17524832   PMID:17524834   PMID:17564305  
PMID:17592131   PMID:17634366   PMID:17675574   PMID:18008141   PMID:18049893   PMID:18219391   PMID:18417691   PMID:18510739   PMID:18614015   PMID:18720057   PMID:18809582   PMID:18817872  
PMID:18986331   PMID:19022905   PMID:19056867   PMID:19171884   PMID:19283469   PMID:19344250   PMID:19369197   PMID:19461023   PMID:19741096   PMID:19828437   PMID:20020182   PMID:20134035  
PMID:20221404   PMID:20510358   PMID:20663894   PMID:20815790   PMID:21257910   PMID:21331057   PMID:21393238   PMID:21625958   PMID:21630459   PMID:21745570   PMID:21942371   PMID:22178654  
PMID:22377061   PMID:22409357   PMID:22451871   PMID:22496122   PMID:22540739   PMID:22732938   PMID:22819776   PMID:22898625   PMID:22905402   PMID:22981416   PMID:23106098   PMID:23376485  
1 to 10 of 14 rows



Sod1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81142,942,742 - 42,948,399 (+)NCBIGRCr8
mRatBN7.21129,456,673 - 29,462,249 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1129,456,558 - 29,462,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1138,144,681 - 38,150,257 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01130,816,072 - 30,821,648 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01130,005,455 - 30,011,012 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01130,363,282 - 30,368,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01133,982,764 - 33,988,340 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41129,810,766 - 29,816,342 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11129,810,765 - 29,816,342 (-)NCBI
Celera1129,143,740 - 29,149,316 (+)NCBICelera
Cytogenetic Map11q11NCBI
SOD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382131,659,693 - 31,668,931 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2131,659,666 - 31,668,931 (+)EnsemblGRCh38hg38GRCh38
GRCh372133,032,006 - 33,041,244 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362131,953,806 - 31,963,115 (+)NCBINCBI36Build 36hg18NCBI36
Build 342131,953,805 - 31,963,112NCBI
Celera2118,215,252 - 18,224,561 (+)NCBICelera
Cytogenetic Map21q22.11ENTREZGENE
HuRef2118,441,963 - 18,451,272 (+)NCBIHuRef
CHM1_12132,593,921 - 32,603,230 (+)NCBICHM1_1
T2T-CHM13v2.02130,027,677 - 30,036,914 (+)NCBIT2T-CHM13v2.0
Sod1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391690,017,650 - 90,023,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1690,017,642 - 90,023,217 (+)EnsemblGRCm39 Ensembl
GRCm381690,220,762 - 90,226,333 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1690,220,754 - 90,226,329 (+)EnsemblGRCm38mm10GRCm38
MGSCv371690,220,987 - 90,226,569 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361690,109,601 - 90,115,183 (+)NCBIMGSCv36mm8
Celera1690,416,380 - 90,421,958 (+)NCBICelera
Cytogenetic Map16C3.3NCBI
cM Map1651.56NCBI
Sod1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540731,263,863 - 31,267,727 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540731,261,451 - 31,267,657 (+)NCBIChiLan1.0ChiLan1.0
SOD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22227,780,102 - 27,788,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12122,639,842 - 22,647,619 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02118,029,831 - 18,037,526 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12131,411,702 - 31,419,432 (+)NCBIpanpan1.1PanPan1.1panPan2
SOD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13126,540,291 - 26,544,212 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3126,486,274 - 26,662,815 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3126,528,080 - 26,536,169 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03126,654,922 - 26,662,986 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3126,654,409 - 26,782,319 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13126,600,785 - 26,608,887 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03126,612,632 - 26,620,712 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03127,118,829 - 27,126,937 (+)NCBIUU_Cfam_GSD_1.0
Sod1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497127,114,944 - 27,122,669 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650010,345,154 - 10,352,867 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650010,345,154 - 10,352,873 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13195,326,649 - 195,337,729 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113195,326,573 - 195,335,273 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213205,620,994 - 205,629,705 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SOD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1260,461,219 - 60,472,999 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660713,004,172 - 3,013,463 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sod1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474520,032,011 - 20,037,958 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474520,032,003 - 20,037,958 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Sod1
9 total Variants

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000002885
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 13 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)11169446234Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)111897620886241447Rat
1598842Glom10Glomerulus QTL 103.4kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)11135331169Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)112328045668280456Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)111945620576331918Rat
724517Uae18Urinary albumin excretion QTL 183.7urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)111647204744285911Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)112295940367959403Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)11104193166113562Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112767241082846715Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)112328045668280456Rat

1 to 10 of 13 rows



alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 16 of 16 rows
RefSeq Transcripts NM_017050 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063270289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC058148 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC082800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209495 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210282 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M21060 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M25157 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X54986 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X55395 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 16 of 16 rows

Ensembl Acc Id: ENSRNOT00000002885   ⟹   ENSRNOP00000002885
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,456,558 - 29,462,249 (+)Ensembl
Rnor_6.0 Ensembl1130,363,280 - 30,368,862 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097395   ⟹   ENSRNOP00000082831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1129,456,968 - 29,462,249 (+)Ensembl
RefSeq Acc Id: NM_017050   ⟹   NP_058746
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,942,823 - 42,948,399 (+)NCBI
mRatBN7.21129,456,673 - 29,462,249 (+)NCBI
Rnor_6.01130,363,282 - 30,368,858 (+)NCBI
Rnor_5.01133,982,764 - 33,988,340 (+)NCBI
RGSC_v3.41129,810,766 - 29,816,342 (-)RGD
Celera1129,143,740 - 29,149,316 (+)RGD
Sequence:
RefSeq Acc Id: XM_063270289   ⟹   XP_063126359
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81142,942,742 - 42,947,253 (+)NCBI
RefSeq Acc Id: NP_058746   ⟸   NM_017050
- UniProtKB: P07632 (UniProtKB/Swiss-Prot),   A6JLB7 (UniProtKB/TrEMBL),   Q6LDS4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002885   ⟸   ENSRNOT00000002885
Ensembl Acc Id: ENSRNOP00000082831   ⟸   ENSRNOT00000097395
RefSeq Acc Id: XP_063126359   ⟸   XM_063270289
- Peptide Label: isoform X1
Superoxide dismutase copper/zinc binding

Name Modeler Protein Id AA Range Protein Structure
AF-P07632-F1-model_v2 AlphaFold P07632 1-154 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13698043
Promoter ID:EPDNEW_R8568
Type:multiple initiation site
Name:Sod1_1
Description:superoxide dismutase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01130,363,282 - 30,363,342EPDNEW


1 to 31 of 31 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-21954 BioCyc
BioCyc Pathway DETOX1-PWY [superoxide radicals degradation] BioCyc
  DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
BioCyc Pathway Image DETOX1-PWY BioCyc
  DETOX1-PWY-1 BioCyc
Ensembl Genes ENSRNOG00000002115 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000002885 ENTREZGENE
Gene3D-CATH 2.60.40.200 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7304983 IMAGE-MGC_LOAD
InterPro SOD-like_Cu/Zn_dom_sf UniProtKB/Swiss-Prot
  SOD_Cu/Zn_/chaperone UniProtKB/Swiss-Prot
  SOD_Cu/Zn_BS UniProtKB/Swiss-Prot
  SOD_Cu_Zn_dom UniProtKB/Swiss-Prot
KEGG Report rno:24786 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105454 IMAGE-MGC_LOAD
NCBI Gene 24786 ENTREZGENE
PANTHER PTHR10003 UniProtKB/Swiss-Prot
Pfam Sod_Cu UniProtKB/Swiss-Prot
PharmGKB SOD1 RGD
PhenoGen Sod1 PhenoGen
PRINTS CUZNDISMTASE UniProtKB/Swiss-Prot
PROSITE SOD_CU_ZN_1 UniProtKB/Swiss-Prot
  SOD_CU_ZN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002115 RatGTEx
Superfamily-SCOP SSF49329 UniProtKB/Swiss-Prot
UniProt A0A8I6G9Z6_RAT UniProtKB/TrEMBL
  A0A8L2Q0T2_RAT UniProtKB/TrEMBL
  A6JLB7 ENTREZGENE, UniProtKB/TrEMBL
  P07632 ENTREZGENE
  Q6LDS4 ENTREZGENE, UniProtKB/TrEMBL
  SODC_RAT UniProtKB/Swiss-Prot
1 to 31 of 31 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-01-24 Sod1  superoxide dismutase 1  Sod1  superoxide dismutase 1, soluble  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Sod1  superoxide dismutase 1, soluble  Sod1  superoxide dismutase 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Sod1  superoxide dismutase 1    Superoxide dismutase 1, soluble  Name updated 629478 APPROVED
2001-12-21 Sod1  Superoxide dismutase 1, soluble      Name updated 69729 APPROVED

Note Type Note Reference
gene_cellular_localization localized to peroxisome 628320
gene_disease mutation of the human homolog is a cause of familial amyotrophic lateral sclerosis (ALS) 737689
gene_expression expression is decreased 1.9 fold in SHR compared with WKY rats 1357414
gene_function dismutates reactive oxygen radical species (ROS) to hydrogen peroxide and molecular oxygen 628320
gene_process prevents accumulation of superoxides in cells 628320
gene_regulation caloric restriction (CR) significantly increased mRNA (>287%) level 628320