Slc2a1 (solute carrier family 2 member 1) - Rat Genome Database

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Gene: Slc2a1 (solute carrier family 2 member 1) Rattus norvegicus
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Symbol: Slc2a1
Name: solute carrier family 2 member 1
RGD ID: 3704
Description: Enables several functions, including D-glucose transmembrane transporter activity; dehydroascorbic acid transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including D-glucose import; cellular response to mechanical stimulus; and dehydroascorbic acid transport. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of hypertension; hypothyroidism; and middle cerebral artery infarction. Human ortholog(s) of this gene implicated in childhood absence epilepsy; glucose transporter type 1 deficiency syndrome (multiple); myelomeningocele; obesity; and type 2 diabetes mellitus. Orthologous to human SLC2A1 (solute carrier family 2 member 1); PARTICIPATES IN facilitative sugar transporter mediated glucose transport pathway; Glut1 deficiency syndrome pathway; hypoxia inducible factor pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-[(2,3,4-trimethoxyphenyl)methyl]piperazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glucose transporter type 1, erythrocyte/brain; GLUT-1; Glut1; GLUTB; GTG1; Gtg3; RATGTG1; solute carrier family 2 (facilitated glucose transporter) member 1; solute carrier family 2 (facilitated glucose transporter), member 1; Solute carrier family 2 a 1 (facilitated glucose transporter) brain; solute carrier family 2, facilitated glucose transporter member 1; solute carrier family 2, member 1; solute carrier family 2,member 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Is Marker For: QTLs:   Bp103  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,002,522 - 138,030,742 (+)NCBIGRCr8
mRatBN7.25132,717,196 - 132,745,416 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,717,196 - 132,745,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,447,151 - 135,475,394 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,203,611 - 137,231,856 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,224,210 - 137,252,451 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,154,677 - 138,182,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,964,114 - 141,992,634 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,690,801 - 139,719,021 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15139,696,029 - 139,724,247 (+)NCBI
Celera5131,243,786 - 131,272,021 (+)NCBICelera
RH 3.4 Map5865.0RGD
Cytogenetic Map5q36NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Slc2a1RatAlzheimer's disease  ISOSLC2A1 (Homo sapiens)2313620 RGD 
Slc2a1Ratcataract  ISOSlc2a1 (Mus musculus)12801446 RGD 
Slc2a1Ratchildhood absence epilepsy onsetISOSLC2A1 (Homo sapiens)11058811DNA:deletion more ...RGD 
Slc2a1Ratdiabetes mellitus  ISOSLC2A1 (Homo sapiens)12879500 RGD 
Slc2a1RatDiabetic Nephropathies  ISOSLC2A1 (Homo sapiens)2312305 RGD 
Slc2a1RatDiabetic Nephropathies treatmentIEP 12879861associated with Diabetes Mellitus and ExperimentalRGD 
Slc2a1RatDiabetic Nephropathies  ISOSLC2A1 (Homo sapiens)12879466associated with Diabetes Mellitus more ...RGD 
Slc2a1Ratdystonia 9  ISOSLC2A1 (Homo sapiens)12879478DNA:missense mutation:exon: p.R212C (c.634C>T) (human)RGD 
Slc2a1RatExperimental Diabetes Mellitus  IEP 2313617mRNA and protein:decreased expression:brainRGD 
Slc2a1RatExperimental Diabetes Mellitus treatmentIEP 12879858 RGD 
Slc2a1RatFetal Growth Retardation  IEP 730192protein:increased expression:placentaRGD 
Slc2a1RatFetal Growth Retardation  IEP 12879480mRNA and protein:increased expression:liverRGD 
Slc2a1Ratglomerulosclerosis  ISOSlc2a1 (Mus musculus)12879501 RGD 
Slc2a1Ratglucose transporter type 1 deficiency syndrome  ISOSLC2A1 (Homo sapiens)1624245 RGD 
Slc2a1Ratglucose transporter type 1 deficiency syndrome  ISOSlc2a1 (Mus musculus)12879476 RGD 
Slc2a1Ratglucose transporter type 1 deficiency syndrome  ISOSLC2A1 (Homo sapiens)12879473DNA:deletions: :multipleRGD 
Slc2a1Ratglucose transporter type 1 deficiency syndrome  ISOSLC2A1 (Homo sapiens)12879464DNA:mutations:exon and intron:multipleRGD 
Slc2a1Rathemangioma  ISOSLC2A1 (Homo sapiens)12879499 RGD 
Slc2a1RatHirschsprung's disease  ISOSLC2A1 (Homo sapiens)12879497 RGD 
Slc2a1Rathypertension  IEP 12879474protein:increased expression:renal glomerulus RGD 
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Original Reference(s)
Slc2a1Ratbenign epilepsy with centrotemporal spikes  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Rolandic epilepsyClinVarPMID:29358611
Slc2a1Ratcerebellar ataxia  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Cerebellar ataxiaClinVar 
Slc2a1RatCharcot-Marie-Tooth disease dominant intermediate C  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Charcot-Marie-Tooth disease dominant intermediate CClinVarPMID:28492532
Slc2a1Ratchromosome 17q23.1-q23.2 deletion syndrome  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Chromosome 17q23.1-q23.2 deletion syndromeClinVarPMID:12325075 more ...
Slc2a1RatDevelopmental Disease  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental disorderClinVarPMID:19630075 more ...
Slc2a1Ratdystonia  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:25741868 and PMID:28492532
Slc2a1Ratdystonia 9  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10980529 more ...
Slc2a1Ratepilepsy  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10980529 more ...
Slc2a1Ratgenetic disease  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:10980529 more ...
Slc2a1Ratglucose transporter type 1 deficiency syndrome  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10980529 more ...
Slc2a1Ratglucose transporter type 1 deficiency syndrome 1  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227690 more ...
Slc2a1Ratglucose transporter type 1 deficiency syndrome 2  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10227690 more ...
Slc2a1RatIdiopathic Generalized Epilepsy 12  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:10980529 more ...
Slc2a1Ratintellectual disability  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10980529 more ...
Slc2a1Ratintellectual disability  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10980529 more ...
Slc2a1Ratintellectual disability  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:18606970 more ...
Slc2a1Ratintellectual disability  ISOSLC2A1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10980529 more ...
Slc2a1Ratjunctional epidermolysis bullosa Herlitz type  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: Herlitz-type junctional epidermolysis bullosaClinVarPMID:20129935 more ...
Slc2a1Ratmicrocephaly  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: MicrocephalyClinVarPMID:10980529 more ...
Slc2a1Ratmigraine  ISOSLC2A1 (Homo sapiens)8554872ClinVar Annotator: match by term: MigraineClinVarPMID:25741868 and PMID:28492532
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Slc2a1RatAtaxia  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11603379
Slc2a1RatBreast Neoplasms  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20197467
Slc2a1RatColonic Neoplasms  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11953883
Slc2a1RatDevelopmental Disabilities  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9462754 more ...
Slc2a1RatDuctal Carcinoma  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20526721
Slc2a1Ratductal carcinoma in situ  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20526721
Slc2a1Ratdystonia 9  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Slc2a1Ratglucose transporter type 1 deficiency syndrome  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9462754 more ...
Slc2a1Rathepatocellular carcinoma  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8364915
Slc2a1Ratinherited metabolic disorder  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23452774
Slc2a1Ratintellectual disability  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21937992
Slc2a1RatLiver Neoplasms  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:26943884
Slc2a1Ratmalignant mesothelioma  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22784439
Slc2a1Ratmicrocephaly  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9462754 and PMID:10980529
Slc2a1RatNeoplastic Cell Transformation  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11953883
Slc2a1Ratnervous system disease  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23452774
Slc2a1Ratosteoarthritis  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18973239
Slc2a1RatOvarian Neoplasms  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20138251
Slc2a1RatPeritoneal Neoplasms  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22784439
Slc2a1Ratrenal cell carcinoma  ISOSLC2A1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7921415
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Slc2a1Ratglucose transporter type 1 deficiency syndrome 1  ISSSlc2a1 (Mus musculus)13592920OMIM:606777MouseDO 

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Original Reference(s)
Slc2a1Rat(-)-epigallocatechin 3-gallate increases expressionEXP 6480464epigallocatechin gallate results in increased expression of SLC2A1 mRNACTDPMID:16988119
Slc2a1Rat(-)-epigallocatechin 3-gallate multiple interactionsISOSLC2A1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of SLC2A1 mRNACTDPMID:22079256
Slc2a1Rat(E)-cinnamyl alcohol multiple interactionsISOSlc2a1 (Mus musculus)6480464[cinnamyl alcohol co-treated with Glucose deficiency] results in decreased activity of SLC2A1 proteinCTDPMID:20955755
Slc2a1Rat(E)-cinnamyl alcohol increases activityISOSlc2a1 (Mus musculus)6480464cinnamyl alcohol results in increased activity of SLC2A1 proteinCTDPMID:20955755
Slc2a1Rat(S)-naringenin multiple interactionsISOSLC2A1 (Homo sapiens)6480464naringenin inhibits the reaction [SLC2A1 protein affects the transport of Glucose]CTDPMID:14642735
Slc2a1Rat(S)-naringenin decreases activityISOSLC2A1 (Homo sapiens)6480464naringenin results in decreased activity of SLC2A1 proteinCTDPMID:14642735
Slc2a1Rat1,2-dimethylhydrazine decreases expressionISOSlc2a1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of SLC2A1 mRNACTDPMID:22206623
Slc2a1Rat1,4-benzoquinone multiple interactionsISOSLC2A1 (Homo sapiens)6480464[HIF1A protein co-treated with quinone] results in increased expression of SLC2A1 proteinCTDPMID:30448556
Slc2a1Rat1-[(2,3,4-trimethoxyphenyl)methyl]piperazine multiple interactionsEXP 6480464Trimetazidine promotes the reaction [Oxygen deficiency results in increased expression of SLC2A1 mRNA]CTDPMID:25937560
Slc2a1Rat1-[(2,3,4-trimethoxyphenyl)methyl]piperazine decreases expressionISOSlc2a1 (Mus musculus)6480464Trimetazidine results in decreased expression of SLC2A1 mRNACTDPMID:37591408
Slc2a1Rat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionEXP 6480464Citalopram results in increased expression of SLC2A1 mRNACTDPMID:28467792
Slc2a1Rat1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine multiple interactionsISOSlc2a1 (Mus musculus)6480464[Probenecid co-treated with 1-Methyl-4-phenyl-1 more ...CTDPMID:25064079
Slc2a1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of SLC2A1 mRNACTDPMID:17522070
Slc2a1Rat17alpha-ethynylestradiol increases expressionISOSlc2a1 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of SLC2A1 mRNACTDPMID:17555576 and PMID:17942748
Slc2a1Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of SLC2A1 mRNACTDPMID:12075121 more ...
Slc2a1Rat17alpha-ethynylestradiol multiple interactionsISOSlc2a1 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SLC2A1 mRNACTDPMID:17942748
Slc2a1Rat17beta-estradiol increases expressionISOSLC2A1 (Homo sapiens)6480464Estradiol results in increased expression of SLC2A1 mRNA and Estradiol results in increased expression of SLC2A1 proteinCTDPMID:14605097 and PMID:15350188
Slc2a1Rat17beta-estradiol increases expressionISOSlc2a1 (Mus musculus)6480464Estradiol results in increased expression of SLC2A1 mRNACTDPMID:39298647
Slc2a1Rat17beta-estradiol affects expressionEXP 6480464Estradiol affects the expression of SLC2A1 mRNACTDPMID:32145629
Slc2a1Rat17beta-estradiol multiple interactionsISOSlc2a1 (Mus musculus)6480464Estradiol inhibits the reaction [Progesterone results in increased expression of and results in increased localization of SLC2A1 protein] and Estradiol inhibits the reaction [Progesterone results in increased expression of SLC2A1 protein]CTDPMID:18948400

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Biological Process
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Original Reference(s)
Slc2a1Ratcellular hyperosmotic response  IEP 12879856 RGD 
Slc2a1Ratcellular response to glucose starvation acts_upstream_of_or_withinIEAUniProtKB:P17809 and ensembl:ENSMUSP000000303981600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratcellular response to glucose starvation acts_upstream_of_or_withinISOSlc2a1 (Mus musculus)1624291 PMID:11259273RGDPMID:11259273
Slc2a1Ratcellular response to mechanical stimulus  IEP 12879501 RGD 
Slc2a1Ratcentral nervous system development acts_upstream_of_or_withinISOSLC2A1 (Homo sapiens)1624291 PMID:10227690 and PMID:1714544RGDPMID:10227690 and PMID:1714544
Slc2a1Ratcentral nervous system development acts_upstream_of_or_withinIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratcerebral cortex development  IEP 12879481 RGD 
Slc2a1RatD-glucose import  IMP 329901803 RGD 
Slc2a1RatD-glucose import involved_inIBAMGI:95758 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc2a1RatD-glucose import across plasma membrane involved_inISOSLC2A1 (Homo sapiens)1624291UniProtKB:P11169 more ...RGDPMID:10227690 more ...
Slc2a1RatD-glucose import across plasma membrane involved_inIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1RatD-glucose transmembrane transport involved_inISOSlc2a1 (Mus musculus)1624291 PMID:18668520RGDPMID:18668520
Slc2a1RatD-glucose transmembrane transport  IDA 2303167 RGD 
Slc2a1RatD-glucose transmembrane transport involved_inIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1RatD-glucose transmembrane transport involved_inIEAInterPro:IPR0024391600115GO_REF:0000002InterProGO_REF:0000002
Slc2a1RatD-glucose transmembrane transport involved_inIEAARBA:ARBA000263181600115GO_REF:0000117UniProtGO_REF:0000117
Slc2a1RatD-glucose transmembrane transport involved_inIEAUniProtKB:P17809 and ensembl:ENSMUSP000000303981600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1RatD-glucose transmembrane transport involved_inISOComplexPortal:CPX-31111600115GO_REF:0000114ComplexPortalGO_REF:0000114
Slc2a1RatD-glucose transmembrane transport involved_inISOSLC2A1 (Homo sapiens)1624291 PMID:1429721 more ...RGDPMID:1429721 more ...
Slc2a1RatD-glucose transmembrane transport involved_inIDA 8554811PMID:18668520UniProt 
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Cellular Component
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Slc2a1Ratapical plasma membrane located_inIDA 2301072PMID:18619525ARUK-UCL 
Slc2a1Ratapical plasma membrane located_inIEAUniProtKB:P17809 and ensembl:ENSMUSP000000303981600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratapical plasma membrane located_inIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratapical plasma membrane is_active_inIBAMGI:95755 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc2a1Ratapical plasma membrane located_inISOSLC2A1 (Homo sapiens)1624291 PMID:31678436 and PMID:31791063RGDPMID:31678436 and PMID:31791063
Slc2a1Ratapical plasma membrane located_inISOSlc2a1 (Mus musculus)1624291 PMID:19841136 and PMID:23202918RGDPMID:19841136 and PMID:23202918
Slc2a1Ratbasolateral plasma membrane located_inIDA 2301072PMID:18619525ARUK-UCL 
Slc2a1Ratbasolateral plasma membrane located_inIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratbasolateral plasma membrane located_inISOSlc2a1 (Mus musculus)1624291 PMID:11259273 and PMID:15975910RGDPMID:11259273 and PMID:15975910
Slc2a1Ratbasolateral plasma membrane is_active_inIBAMGI:95755 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc2a1Ratbasolateral plasma membrane located_inIEAUniProtKB:P17809 and ensembl:ENSMUSP000000303981600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratbasolateral plasma membrane located_inISOSLC2A1 (Homo sapiens)1624291 PMID:31791063RGDPMID:31791063
Slc2a1Ratcaveola  IDA 1601538 RGD 
Slc2a1Ratcell-cell junction  IDA 1624247 RGD 
Slc2a1Ratcortical actin cytoskeleton located_inISSUniProtKB:P111661600115GO_REF:0000024UniProtGO_REF:0000024
Slc2a1Ratcortical actin cytoskeleton located_inIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratcortical actin cytoskeleton located_inISOSLC2A1 (Homo sapiens)1624291 PMID:18347014RGDPMID:18347014
Slc2a1Ratcytoplasm located_inISOSlc2a1 (Mus musculus)1624291 PMID:18668520RGDPMID:18668520
Slc2a1Ratcytoplasm located_inIEAUniProtKB:P17809 and ensembl:ENSMUSP000000303981600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratcytoplasm located_inIDA 8554811PMID:18668520UniProt 
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Molecular Function
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Slc2a1RatD-glucose transmembrane transporter activity enablesISOSlc2a1 (Mus musculus)1624291 PMID:18668520 and PMID:33508319RGDPMID:18668520 and PMID:33508319
Slc2a1RatD-glucose transmembrane transporter activity  IDA 2303167 RGD 
Slc2a1RatD-glucose transmembrane transporter activity enablesIBAMGI:1095438 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Slc2a1RatD-glucose transmembrane transporter activity enablesIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1RatD-glucose transmembrane transporter activity enablesIEAUniProtKB:P17809 and ensembl:ENSMUSP000000303981600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1RatD-glucose transmembrane transporter activity enablesIEAInterPro:IPR0024391600115GO_REF:0000002InterProGO_REF:0000002
Slc2a1RatD-glucose transmembrane transporter activity enablesISOSLC2A1 (Homo sapiens)1624291 PMID:10227690 more ...RGDPMID:10227690 more ...
Slc2a1RatD-glucose transmembrane transporter activity enablesIDA 8554811PMID:18668520UniProt 
Slc2a1Ratdehydroascorbic acid transmembrane transporter activity enablesISOSLC2A1 (Homo sapiens)1624291 PMID:10862609 and PMID:9228080RGDPMID:10862609 and PMID:9228080
Slc2a1Ratdehydroascorbic acid transmembrane transporter activity enablesISOSlc2a1 (Mus musculus)1624291 PMID:18668520RGDPMID:18668520
Slc2a1Ratdehydroascorbic acid transmembrane transporter activity enablesIEAUniProtKB:P17809 and ensembl:ENSMUSP000000303981600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratdehydroascorbic acid transmembrane transporter activity enablesIDA 8554811PMID:18668520UniProt 
Slc2a1Ratfucose transmembrane transporter activity enablesISOSlc2a1 (Mus musculus)1624291 PMID:36423686RGDPMID:36423686
Slc2a1Ratfucose transmembrane transporter activity enablesIEAUniProtKB:P17809 and ensembl:ENSMUSP000000303981600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Rathexose transmembrane transporter activity enablesIEAARBA:ARBA000287901600115GO_REF:0000117UniProtGO_REF:0000117
Slc2a1Ratidentical protein binding enablesISOSLC2A1 (Homo sapiens)1624291UniProtKB:P11166 and PMID:1429721RGDPMID:1429721
Slc2a1Ratidentical protein binding enablesIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
Slc2a1Ratkinase binding  IPIHk1 (Rattus norvegicus)1601538 RGD 
Slc2a1Ratlong-chain fatty acid transmembrane transporter activity enablesISOSLC2A1 (Homo sapiens)1624291 PMID:10227690RGDPMID:10227690
Slc2a1Ratlong-chain fatty acid transmembrane transporter activity enablesIEAUniProtKB:P11166 and ensembl:ENSP000004162931600115GO_REF:0000107EnsemblGO_REF:0000107
1 to 20 of 27 rows

RGD Manual Annotations


  

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc2a1RatGlut1 deficiency syndrome pathway  ISOSLC2A1 (Homo sapiens)10402751 SMPDBSMP:00580
Slc2a1Ratlactose biosynthetic pathway  ISOSLC2A1 (Homo sapiens)10402751 SMPDBSMP:00444

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc2a1Ratbile acid transport pathway  IEA 6907045 KEGGrno:04976
Slc2a1Ratrenal cell carcinoma pathway   IEA 6907045 KEGGrno:05211

Imported Annotations - PID (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Slc2a1Rathypoxia inducible factor pathway   ISOSLC2A1 (Homo sapiens)6484113 PIDPID:200202
Slc2a1Rathypoxia inducible factor pathway   ISOSLC2A1 (Homo sapiens)6484113 PIDPID:200036

1 to 20 of 77 rows
#
Reference Title
Reference Citation
1. Association of HaeIII single nucleotide polymorphisms in the SLC2A1 gene with risk of diabetic nephropathy; evidence from Kurdish patients with type 2 diabetes mellitus. Amini S, etal., QJM. 2016 Jun;109(6):399-404. doi: 10.1093/qjmed/hcv149. Epub 2015 Sep 3.
2. Molecular identification and functional characterization of the vitamin C transporters expressed by Sertoli cells. Angulo C, etal., J Cell Physiol. 2008 Dec;217(3):708-16. doi: 10.1002/jcp.21545.
3. Activation of GLUT1 by metabolic and osmotic stress: potential involvement of AMP-activated protein kinase (AMPK). Barnes K, etal., J Cell Sci 2002 Jun 1;115(Pt 11):2433-42.
4. Affected sib-pair analysis of the GLUT1 glucose transporter gene locus in non-insulin-dependent diabetes mellitus (NIDDM): evidence for no linkage. Baroni MG, etal., Hum Genet. 1994 Jun;93(6):675-80.
5. Cloning and characterization of a cDNA encoding the rat brain glucose-transporter protein. Birnbaum MJ, etal., Proc Natl Acad Sci U S A 1986 Aug;83(16):5784-8.
6. Glucose deprivation and hypoxia increase the expression of the GLUT1 glucose transporter via a specific mRNA cis-acting regulatory element. Boado RJ and Pardridge WM, J Neurochem 2002 Feb;80(3):552-4.
7. The cellular fate of glucose and its relevance in type 2 diabetes. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
8. Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex. Cholet N, etal., Cereb Cortex 2002 May;12(5):515-25.
9. A 10 bp deletion polymorphism and 2 new variations in the GLUT1 gene associated with meningomyelocele. Cormier CM, etal., Reprod Sci. 2011 May;18(5):463-8. doi: 10.1177/1933719110388293. Epub 2010 Dec 6.
10. Immunolocalization of GLUT-1 glucose transporter in rat skeletal muscle and in normal and hypoxic cardiac tissue. Doria-Medina CL, etal., Am J Physiol. 1993 Sep;265(3 Pt 1):E454-64.
11. Diabetes alters the expression and activity of the human placental GLUT1 glucose transporter. Gaither K, etal., J Clin Endocrinol Metab. 1999 Feb;84(2):695-701.
12. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
13. Asymmetric subcellular distribution of glucose transporters in the endothelium of small contractile arteries. Gaudreault N, etal., Endothelium. 2006 Sep-Oct;13(5):317-24.
14. Effects of chronic undernutrition on glucose uptake and glucose transporter proteins in rat heart. Gavete ML, etal., Endocrinology 2002 Nov;143(11):4295-303.
15. GLUT-1 overexpression: Link between hemodynamic and metabolic factors in glomerular injury? Gnudi L, etal., Hypertension. 2003 Jul;42(1):19-24. Epub 2003 May 27.
16. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
17. Development of cataractous macrophthalmia in mice expressing an active MEK1 in the lens. Gong X, etal., Invest Ophthalmol Vis Sci. 2001 Mar;42(3):539-48.
18. GLUT1 gene polymorphism in non-insulin-dependent diabetes mellitus: genetic susceptibility relationship with cardiovascular risk factors and microangiopathic complications in a Mediterranean population. Gutierrez C, etal., Diabetes Res Clin Pract. 1998 Aug;41(2):113-20.
19. Pre-germinated brown rice extract ameliorates high-fat diet-induced metabolic syndrome. Hao CL, etal., J Food Biochem. 2019 Mar;43(3):e12769. doi: 10.1111/jfbc.12769. Epub 2019 Jan 13.
20. SLC2A1 gene analysis of Japanese patients with glucose transporter 1 deficiency syndrome. Hashimoto N, etal., J Hum Genet. 2011 Dec;56(12):846-51. doi: 10.1038/jhg.2011.115. Epub 2011 Oct 20.
1 to 20 of 77 rows
PMID:1429721   PMID:1714544   PMID:3198639   PMID:7589840   PMID:7593639   PMID:8457197   PMID:9751501   PMID:10198040   PMID:10227690   PMID:10394363   PMID:10862609   PMID:11172003  
PMID:11259273   PMID:11681785   PMID:12002265   PMID:12506324   PMID:12531786   PMID:14519432   PMID:14729246   PMID:14741039   PMID:15166316   PMID:15359219   PMID:15489334   PMID:15808844  
PMID:15811071   PMID:15855808   PMID:15975910   PMID:16091581   PMID:16140905   PMID:16162661   PMID:16449286   PMID:16461188   PMID:17189352   PMID:17369047   PMID:17369472   PMID:17878754  
PMID:18196278   PMID:18245775   PMID:18347014   PMID:18474279   PMID:18511518   PMID:18650261   PMID:18787834   PMID:18797165   PMID:18802725   PMID:18957618   PMID:19546347   PMID:19681047  
PMID:19841136   PMID:19950593   PMID:20375116   PMID:20458337   PMID:21069159   PMID:21141602   PMID:21562080   PMID:21605500   PMID:21613414   PMID:21624469   PMID:21773965   PMID:21791420  
PMID:22125125   PMID:22258767   PMID:22433294   PMID:22516433   PMID:22579067   PMID:22871113   PMID:23265586   PMID:23280796   PMID:23680377   PMID:23975336   PMID:24062089   PMID:24329691  
PMID:24382486   PMID:24610532   PMID:24726496   PMID:24739976   PMID:25101238   PMID:25982116   PMID:26347179   PMID:26590355   PMID:26953753   PMID:27078104   PMID:28495754   PMID:28993322  
PMID:29476059   PMID:29490264   PMID:30335140   PMID:30837370   PMID:31162576   PMID:31765739   PMID:32445055   PMID:33856052   PMID:35038771   PMID:35084654   PMID:35380292   PMID:35713797  
PMID:36291063   PMID:36521282   PMID:36963496   PMID:37879153  



Slc2a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85138,002,522 - 138,030,742 (+)NCBIGRCr8
mRatBN7.25132,717,196 - 132,745,416 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5132,717,196 - 132,745,416 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5135,447,151 - 135,475,394 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05137,203,611 - 137,231,856 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05137,224,210 - 137,252,451 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05138,154,677 - 138,182,897 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05141,964,114 - 141,992,634 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45139,690,801 - 139,719,021 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15139,696,029 - 139,724,247 (+)NCBI
Celera5131,243,786 - 131,272,021 (+)NCBICelera
RH 3.4 Map5865.0RGD
Cytogenetic Map5q36NCBI
SLC2A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38142,925,353 - 42,958,868 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl142,925,353 - 42,958,893 (-)EnsemblGRCh38hg38GRCh38
GRCh37143,391,024 - 43,424,539 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36143,164,102 - 43,197,088 (-)NCBINCBI36Build 36hg18NCBI36
Build 34143,060,611 - 43,093,594NCBI
Celera141,673,133 - 41,706,939 (-)NCBICelera
Cytogenetic Map1p34.2NCBI
HuRef141,511,000 - 41,544,561 (-)NCBIHuRef
CHM1_1143,507,796 - 43,541,586 (-)NCBICHM1_1
T2T-CHM13v2.0142,795,821 - 42,829,338 (-)NCBIT2T-CHM13v2.0
Slc2a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm394118,966,001 - 118,994,527 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl4118,965,908 - 118,995,180 (+)EnsemblGRCm39 Ensembl
GRCm384119,108,745 - 119,137,330 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl4119,108,711 - 119,137,983 (+)EnsemblGRCm38mm10GRCm38
MGSCv374118,781,350 - 118,809,935 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv364118,606,700 - 118,635,259 (+)NCBIMGSCv36mm8
Celera4117,836,249 - 117,864,839 (+)NCBICelera
Cytogenetic Map4D2.1NCBI
cM Map455.34NCBI
Slc2a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555372,408,042 - 2,439,511 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555372,408,042 - 2,438,788 (-)NCBIChiLan1.0ChiLan1.0
SLC2A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21183,853,979 - 183,886,954 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11182,995,645 - 183,028,526 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,224,273 - 42,257,184 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1143,600,733 - 43,634,143 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl143,600,733 - 43,634,143 (-)Ensemblpanpan1.1panPan2
SLC2A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.115463,307 - 493,145 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl15463,237 - 493,140 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha15719,928 - 748,675 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.015546,520 - 575,271 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl15546,386 - 575,265 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.115456,107 - 484,827 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.015515,411 - 544,075 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.015532,601 - 561,334 (+)NCBIUU_Cfam_GSD_1.0
Slc2a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505858,381,102 - 58,411,854 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647424,206,644 - 24,236,713 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647424,205,878 - 24,236,611 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC2A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12089,974,567 - 90,007,977 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2090,002,030 - 90,008,033 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603326,904,125 - 26,937,791 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc2a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248922,117,561 - 2,148,037 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248922,110,310 - 2,148,023 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Slc2a1
202 total Variants


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 141991672 141991673 G T snv LE/OrlBarth (UDEL) View more Information

Predicted Target Of
Summary Value
Count of predictions:456
Count of miRNA genes:236
Interacting mature miRNAs:280
Transcripts:ENSRNOT00000064452
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 48 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
10053720Scort26Serum corticosterone level QTL 262.060.0147blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)5124965598166875058Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
8552960Pigfal15Plasma insulin-like growth factor 1 level QTL 15blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5111416838156416838Rat
1300122Wbc1White blood cell count QTL 12.75leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)5125392826139989768Rat
7365049Bp359Blood pressure QTL 359arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)5128071929134724733Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
70156Niddm30Non-insulin dependent diabetes mellitus QTL 303.98blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)5129132447151006154Rat
8552908Pigfal4Plasma insulin-like growth factor 1 level QTL 46.6blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)5128506074166875058Rat
1331803Rf32Renal function QTL 322.798kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)5129132428143070159Rat

1 to 10 of 48 rows
D5Wox11  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25132,743,341 - 132,743,469 (+)MAPPERmRatBN7.2
Rnor_6.05138,180,823 - 138,180,950NCBIRnor6.0
Rnor_5.05141,990,560 - 141,990,687UniSTSRnor5.0
RGSC_v3.45139,716,946 - 139,717,074RGDRGSC3.4
RGSC_v3.45139,716,947 - 139,717,074UniSTSRGSC3.4
RGSC_v3.15139,722,172 - 139,722,300RGD
Celera5131,269,936 - 131,270,074UniSTS
RH 3.4 Map5868.7UniSTS
RH 3.4 Map5868.7RGD
RH 2.0 Map5861.1RGD
Cytogenetic Map5q36.1UniSTS
D5Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25132,744,136 - 132,744,368 (+)MAPPERmRatBN7.2
Rnor_6.05138,181,618 - 138,181,849NCBIRnor6.0
Rnor_5.05141,991,355 - 141,991,586UniSTSRnor5.0
RGSC_v3.45139,717,741 - 139,717,973RGDRGSC3.4
RGSC_v3.45139,717,742 - 139,717,973UniSTSRGSC3.4
RGSC_v3.15139,722,967 - 139,723,199RGD
Celera5131,270,742 - 131,270,973UniSTS
RH 3.4 Map5867.2RGD
RH 3.4 Map5867.2UniSTS
RH 2.0 Map5860.2RGD
SHRSP x BN Map570.6499RGD
Cytogenetic Map5q36.1UniSTS
Cytogenetic Map5q36UniSTS
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25132,744,921 - 132,745,113 (+)MAPPERmRatBN7.2
Rnor_6.05138,182,403 - 138,182,594NCBIRnor6.0
Rnor_5.05141,992,140 - 141,992,331UniSTSRnor5.0
RGSC_v3.45139,718,527 - 139,718,718UniSTSRGSC3.4
Celera5131,271,527 - 131,271,718UniSTS
Cytogenetic Map5q36UniSTS
Cytogenetic Map5q36.1UniSTS
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85138,025,892 - 138,026,656 (+)Marker Load Pipeline
mRatBN7.25132,740,566 - 132,741,330 (+)MAPPERmRatBN7.2
Rnor_6.05138,178,048 - 138,178,811NCBIRnor6.0
Rnor_5.05141,987,785 - 141,988,548UniSTSRnor5.0
RGSC_v3.45139,714,172 - 139,714,935UniSTSRGSC3.4
Celera5131,267,161 - 131,267,924UniSTS
Cytogenetic Map5q36.1UniSTS
Slc2a1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25132,743,856 - 132,745,113 (+)MAPPERmRatBN7.2
Rnor_6.05138,181,338 - 138,182,594NCBIRnor6.0
Rnor_5.05141,991,075 - 141,992,331UniSTSRnor5.0
Celera5131,270,462 - 131,271,718UniSTS
Cytogenetic Map5q36.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000064452   ⟹   ENSRNOP00000061340
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5132,717,196 - 132,745,416 (+)Ensembl
Rnor_6.0 Ensembl5138,154,673 - 138,182,897 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083700   ⟹   ENSRNOP00000072351
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5132,728,277 - 132,745,416 (+)Ensembl
Rnor_6.0 Ensembl5138,164,480 - 138,182,011 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106473   ⟹   ENSRNOP00000090216
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5132,728,055 - 132,745,416 (+)Ensembl
RefSeq Acc Id: NM_138827   ⟹   NP_620182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85138,002,522 - 138,030,742 (+)NCBI
mRatBN7.25132,717,196 - 132,745,416 (+)NCBI
Rnor_6.05138,154,677 - 138,182,897 (+)NCBI
Rnor_5.05141,964,114 - 141,992,634 (+)NCBI
RGSC_v3.45139,690,801 - 139,719,021 (+)RGD
Celera5131,243,786 - 131,272,021 (+)RGD
Sequence:
Protein RefSeqs NP_620182 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41248 (Get FASTA)   NCBI Sequence Viewer  
  AAA41297 (Get FASTA)   NCBI Sequence Viewer  
  AAH61873 (Get FASTA)   NCBI Sequence Viewer  
  EDL90143 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000061340
  ENSRNOP00000061340.1
GenBank Protein P11167 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620182   ⟸   NM_138827
- UniProtKB: P11167 (UniProtKB/Swiss-Prot),   A6JZL0 (UniProtKB/TrEMBL),   A0A8I6ABD3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072351   ⟸   ENSRNOT00000083700
Ensembl Acc Id: ENSRNOP00000061340   ⟸   ENSRNOT00000064452
Ensembl Acc Id: ENSRNOP00000090216   ⟸   ENSRNOT00000106473
Major facilitator superfamily (MFS) profile

Name Modeler Protein Id AA Range Protein Structure
AF-P11167-F1-model_v2 AlphaFold P11167 1-492 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693972
Promoter ID:EPDNEW_R4497
Type:multiple initiation site
Name:Slc2a1_1
Description:solute carrier family 2 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05138,154,734 - 138,154,794EPDNEW


1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40101 BioCyc
Ensembl Genes ENSRNOG00000007284 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000064452 ENTREZGENE
  ENSRNOT00000064452.3 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5598829 IMAGE-MGC_LOAD
InterPro Glu_transpt_1 UniProtKB/Swiss-Prot
  GLUT UniProtKB/Swiss-Prot
  MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Sugar/inositol_transpt UniProtKB/Swiss-Prot
  Sugar_transporter_CS UniProtKB/Swiss-Prot
KEGG Report rno:24778 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72306 IMAGE-MGC_LOAD
NCBI Gene 24778 ENTREZGENE
PANTHER PTHR23503 UniProtKB/Swiss-Prot
  SOLUTE CARRIER FAMILY 2, FACILITATED GLUCOSE TRANSPORTER MEMBER 1 UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PharmGKB SLC2A1 RGD
PhenoGen Slc2a1 PhenoGen
PRINTS GLUCTRSPORT1 UniProtKB/Swiss-Prot
  SUGRTRNSPORT UniProtKB/Swiss-Prot
PROSITE MFS UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_1 UniProtKB/Swiss-Prot
  SUGAR_TRANSPORT_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007284 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0A0G2K2S2_RAT UniProtKB/TrEMBL
  A0A8I6ABD3 ENTREZGENE, UniProtKB/TrEMBL
  A6JZL0 ENTREZGENE, UniProtKB/TrEMBL
  GTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc2a1  solute carrier family 2 member 1  Slc2a1  solute carrier family 2 (facilitated glucose transporter), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc2a1  solute carrier family 2 (facilitated glucose transporter), member 1    solute carrier family 2,member 1  Name updated 1299863 APPROVED
2002-06-10 Slc2a1  solute carrier family 2,member 1      Name updated 70585 PROVISIONAL

Note Type Note Reference
gene_disease insulin treatment causes a redistribution to heart plasma membrane 628382
gene_drugs Doxorubicin also known as adriamycin a highly effective antineoplastic drug induces cardiotoxicity thus stimulating this gene and regulating glucose uptake in heart cells 628382
gene_expression expressed in cardiac myocytes 628382
gene_expression chronic food restriction decreases the expression of cardiac mRNA  
gene_expression expressed in mammary epithelial cells during pregnancy and lactation; expression decreases during weaning 1299031
gene_homology protein has 97.6% identity to human hepatoma hexose carrier protein 729978
gene_process responsible for glucose entry into the brain  
gene_process may be responsible for constitutive or basal glucose uptake  
gene_process enhances glucose uptake in the heart after undernutrition due to the increased protein distribution to the surface membrane 628382
gene_process major glucose carrier in heart 628429
gene_process plays a role in placental glucose transport 1299030
gene_product member of the sugar transporter family  
gene_protein predicted to encode 492 amino acid protein 729978
gene_regulation chronic food restriction decreases the expression of cardiac mRNA 628382
gene_regulation increased glucose transport and increased transporter accessibility to substrate is induced by AMP activated protein kinase 730230
gene_regulation cis-acting regulatory element in 3'-untranslated region (CAE2181-2190) plays a role in increase in gene expression during glucose deprivation and hypoxia 1299029
gene_regulation transcription factor Sp1 may be involved in regulation of expression during trophoblast differentiation 1299030