Ren (renin) - Rat Genome Database

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Gene: Ren (renin) Rattus norvegicus
Analyze
Symbol: Ren
Name: renin
RGD ID: 3554
Description: Enables endopeptidase activity and insulin-like growth factor receptor binding activity. Involved in several processes, including angiotensin maturation; response to cGMP; and response to lipopolysaccharide. Located in extracellular space. Used to study hypertension. Biomarker of hypertension; metabolic dysfunction and alcohol associated liver disease; and primary biliary cholangitis. Human ortholog(s) of this gene implicated in essential hypertension; familial juvenile hyperuricemic nephropathy; hand, foot and mouth disease; hypertension; and portal hypertension. Orthologous to human REN (renin); PARTICIPATES IN renin-angiotensin cascade pathway; benazepril pharmacodynamics pathway; candesartan pharmacodynamics pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 11-deoxycorticosterone; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: angiotensinogenase; RATRENAA; Ren1; RENAA; renin 1; renin 1 structural
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Renem1Mcwi  
Genetic Models: SS-Renem1Mcwi SS-Renem1Mcwi+/- SS-Renem1Mcwi-/-
Is Marker For: Strains:   SS.BN-(D13Rat20-D13Rat127)/Mcwi   SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi  
QTLs:   Bp24   Bp5  
Candidate Gene For: Bp80 Bp328 Bp395
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81347,348,312 - 47,359,539 (+)NCBIGRCr8
mRatBN7.21344,796,260 - 44,807,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,796,091 - 44,807,489 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,406,270 - 47,416,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,694,375 - 48,704,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,952,438 - 45,963,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
Species
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Evidence
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Reference
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Original Reference(s)
RenRatacute kidney failure exacerbatesISOREN (Homo sapiens)125097506Associated with toxic shock syndrome and protein:increased expression:blood plasma (human) RGD 
RenRatatrial fibrillation  ISOREN (Homo sapiens)6892701associated with Rheumatic Heart Disease and protein:increased activity:plasma (human)RGD 
RenRatCardiomegaly  ISORen1 (Mus musculus)6771378mRNA:increased expression:heart and kidney (mouse)RGD 
RenRatchronic fatigue syndrome  ISOREN (Homo sapiens)6892702associated with Postural Orthostatic Tachycardia Syndrome and protein:increased activity:plasma (human)RGD 
RenRatChronic Intermittent Hypoxia  IEP 401793731mRNA:increased expression:kidney medulla (rat)RGD 
RenRatcolitis treatmentISORen1 (Mus musculus)125097500 RGD 
RenRatcongenital adrenal hyperplasia  ISOREN (Homo sapiens)125097501protein:increased expression:blood serum (human)RGD 
RenRatcongestive heart failure exacerbatesISOREN (Homo sapiens)126908011protein:increased activity:blood plasma (human)RGD 
RenRatCritical Illness exacerbatesISOREN (Homo sapiens)125097479protein:increased activity:blood plasma (human)RGD 
RenRatdepressive disorder  ISOREN (Homo sapiens)125097507Associated with hypertension and protein:decreased activity:blood (human)RGD 
RenRatDiabetic Nephropathies  IDA 1579795 RGD 
RenRatEndotoxemia  IEP 125097499protein:increased activity:blood plasma (rat)RGD 
RenRatEndotoxemia  ISORen1 (Mus musculus)125097481protein:increased activity:blood plasma (mouse)RGD 
RenRatessential hypertension  ISOREN (Homo sapiens)125097505 RGD 
RenRathand, foot and mouth disease treatmentISOREN (Homo sapiens)127285374 RGD 
RenRathuman cytomegalovirus infection  ISOREN (Homo sapiens)40400905protein:decreased expression:blood plasma (human)RGD 
RenRathypertension  ISORen1 (Mus musculus)6784501 RGD 
RenRathypertension treatmentIEP 401793709 RGD 
RenRathypertension  ISORen1 (Mus musculus)6892655protein:decreased activity:plasma (mouse)RGD 
RenRathypertension  ISOREN (Homo sapiens)1580697 RGD 
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Original Reference(s)
RenRatautistic disorder  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
RenRatAutosomal Dominant Tubulointerstitial Kidney Disease 4  ISOREN (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16116425 more ...
RenRatfamilial adult myoclonic epilepsy 5  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: Epilepsy more ...ClinVarPMID:28492532
RenRatgastrointestinal stromal tumor  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: Gastrointestinal stromal tumorClinVarPMID:28492532
RenRatgenetic disease  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:21473025 more ...
RenRathepatoblastoma  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: HepatoblastomaClinVarPMID:25741868 and PMID:28492532
RenRatHypokalemic Periodic Paralysis, Type 1  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: Hypokalemic periodic paralysis and type 1ClinVarPMID:28492532
RenRatkidney disease  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: renal diseaseClinVarPMID:25741868 and PMID:28492532
RenRatnephrotic syndrome  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: Nephrotic syndromeClinVar 
RenRatparathyroid carcinoma  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: Parathyroid carcinomaClinVarPMID:28492532
RenRatRenal Tubular Dysgenesis  ISOREN (Homo sapiens)8554872ClinVar more ...ClinVarPMID:16116425 more ...
RenRatTonne-Kalscheuer syndrome  ISOREN (Homo sapiens)8554872ClinVar Annotator: match by term: TONNE-KALSCHEUER SYNDROMEClinVarPMID:21036942 more ...
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Original Reference(s)
RenRatAlbuminuria  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12414515 and PMID:18679781
RenRatanemia  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:3524928
RenRatAutosomal Dominant Tubulointerstitial Kidney Disease 4  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
RenRatAzotemia  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6338847
RenRatBartter disease  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:929154 more ...
RenRatCardiomegaly  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20429690 and PMID:20811386
RenRatcongestive heart failure  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:1647690 more ...
RenRatDrug-Related Side Effects and Adverse Reactions  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8723173
RenRatExperimental Diabetes Mellitus  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18829990
RenRatFetal Growth Retardation  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17537837
RenRatFibrosis  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12414515
RenRatHemorrhage  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6991409
RenRathypertension  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:45830 more ...
RenRatHypotension  ISOREN (Homo sapiens)11554173CTD more ...CTDPMID:3536153 more ...
RenRatischemia  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:3915608
RenRatkidney disease  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:6156352 more ...
RenRatLeft Ventricular Hypertrophy  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8349331 and PMID:18679781
RenRatLiddle syndrome  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12185466
RenRatliver cirrhosis  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15613622
RenRatmalignant hypertension  ISOREN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2493837
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Original Reference(s)
RenRatAutosomal Dominant Tubulointerstitial Kidney Disease 4  ISOREN (Homo sapiens)7240710 OMIM 
RenRatRenal Tubular Dysgenesis  ISOREN (Homo sapiens)7240710 OMIM 

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Original Reference(s)
RenRat(R)-adrenaline multiple interactionsISOREN (Homo sapiens)6480464ICI 118551 inhibits the reaction [Epinephrine results in increased activity of REN protein]CTDPMID:6314140
RenRat(R)-adrenaline increases activityISOREN (Homo sapiens)6480464Epinephrine results in increased activity of REN proteinCTDPMID:6314140 and PMID:8592096
RenRat1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol decreases activityISOREN (Homo sapiens)6480464Oxprenolol results in decreased activity of REN proteinCTDPMID:6173514 more ...
RenRat1-(propan-2-ylamino)-3-(2-prop-2-enoxyphenoxy)-2-propanol multiple interactionsISOREN (Homo sapiens)6480464[Oxprenolol co-treated with Indomethacin] results in decreased activity of REN proteinCTDPMID:7049707
RenRat1-naphthyl isothiocyanate decreases expressionEXP 64804641-Naphthylisothiocyanate results in decreased expression of REN mRNACTDPMID:30723492
RenRat11-deoxycorticosterone multiple interactionsEXP 6480464[Desoxycorticosterone co-treated with Sodium Chloride] results in decreased expression of REN proteinCTDPMID:11039
RenRat17alpha-ethynylestradiol multiple interactionsISOREN (Homo sapiens)6480464AGT gene polymorphism promotes the reaction [Ethinyl Estradiol results in increased activity of REN protein] and Furosemide inhibits the reaction [Ethinyl Estradiol results in increased expression of REN protein]CTDPMID:11095476
RenRat17alpha-ethynylestradiol increases activityISOREN (Homo sapiens)6480464Ethinyl Estradiol results in increased activity of REN proteinCTDPMID:11095476
RenRat17beta-estradiol increases expressionISORen1 (Mus musculus)6480464Estradiol results in increased expression of REN1 mRNACTDPMID:39298647
RenRat17beta-estradiol increases expressionISOREN (Homo sapiens)6480464Estradiol results in increased expression of REN mRNACTDPMID:31614463
RenRat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISORen1 (Mus musculus)6480464AHR protein promotes the reaction [Tetrachlorodibenzodioxin results in decreased expression of REN1 mRNA]CTDPMID:12151645
RenRat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of REN mRNACTDPMID:33387578
RenRat2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 4017937092 more ...RGD 
RenRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of REN mRNACTDPMID:32109520
RenRat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISORen1 (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of REN1 mRNACTDPMID:12151645 and PMID:12215675
RenRat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of REN1 mRNACTDPMID:21346803
RenRat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of REN1 mRNACTDPMID:21346803
RenRat2-hydroxypropanoic acid decreases expressionISOREN (Homo sapiens)6480464Lactic Acid results in decreased expression of REN mRNACTDPMID:30851411
RenRat2-Phenylaminoadenosine increases activityEXP 64804642-phenylaminoadenosine results in increased activity of REN proteinCTDPMID:2203898
RenRat3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine multiple interactionsEXP 6480464Puromycin Aminonucleoside affects the expression of and affects the activity of REN protein and Puromycin Aminonucleoside results in increased expression of and results in increased activity of REN proteinCTDPMID:2236972 and PMID:8446257

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Biological Process
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Original Reference(s)
RenRatamyloid-beta metabolic process  IEP 6892653 RGD 
RenRatangiotensin maturation  IDA 5132599 RGD 
RenRatangiotensin maturation involved_inIEAUniProtKB:P00797 and ensembl:ENSP000002721901600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatangiotensin maturation involved_inIEAUniProtKB:P06281 and ensembl:ENSMUSP000000921351600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatangiotensin maturation involved_inIBAMGI:97898 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RenRatangiotensin maturation involved_inISOREN (Homo sapiens) and UniProtKB:P00797-11624291 PMID:12045255RGDPMID:12045255
RenRatangiotensin maturation acts_upstream_of_or_withinISORen1 (Mus musculus)1624291MGI:2136642 PMID:10617578RGDPMID:10617578
RenRatangiotensin maturation involved_inISORen1 (Mus musculus)1624291 PMID:27649628 and PMID:6337154RGDPMID:27649628 and PMID:6337154
RenRatcell maturation acts_upstream_of_or_withinISORen1 (Mus musculus)1624291MGI:2136642 PMID:10617578RGDPMID:10617578
RenRatcell maturation acts_upstream_of_or_withinIEAUniProtKB:P06281 and ensembl:ENSMUSP000000921351600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatcellular response to xenobiotic stimulus  IEP 6892652secretagogue C4880RGD 
RenRatdrinking behavior acts_upstream_of_or_withinISORen1 (Mus musculus)1624291MGI:2136642 PMID:10617578RGDPMID:10617578
RenRatdrinking behavior acts_upstream_of_or_withinIEAUniProtKB:P06281 and ensembl:ENSMUSP000000921351600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatestablishment of blood-nerve barrier NOT|acts_upstream_of_or_withinISORen1 (Mus musculus)1624291MGI:2136642 PMID:10617578RGDPMID:10617578
RenRathormone-mediated signaling pathway acts_upstream_of_or_withinISORen1 (Mus musculus)1624291 PMID:14583438RGDPMID:14583438
RenRathormone-mediated signaling pathway acts_upstream_of_or_withinIEAUniProtKB:P06281 and ensembl:ENSMUSP000000921351600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatjuxtaglomerular apparatus development  IEP 155631307 RGD 
RenRatkidney development involved_inISOREN (Homo sapiens)1624291 PMID:16116425RGDPMID:16116425
RenRatkidney development involved_inIEAUniProtKB:P00797 and ensembl:ENSP000002721901600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatmale gonad development involved_inISORen1 (Mus musculus)1624291 PMID:11145610RGDPMID:11145610
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Cellular Component
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Original Reference(s)
RenRatapical part of cell located_inISOREN (Homo sapiens)1624291 PMID:26322847RGDPMID:26322847
RenRatapical part of cell located_inIEAUniProtKB:P00797 and ensembl:ENSP000002721901600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatextracellular region is_active_inISORen1 (Mus musculus)1624291 PMID:10318840 and PMID:27649628RGDPMID:10318840 and PMID:27649628
RenRatextracellular region located_inIEAUniProtKB-SubCell:SL-02431600115GO_REF:0000044UniProtGO_REF:0000044
RenRatextracellular region is_active_inIEAUniProtKB:P06281 and ensembl:ENSMUSP000000921351600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatextracellular region located_inIEAUniProtKB-KW:KW-09641600115GO_REF:0000043UniProtGO_REF:0000043
RenRatextracellular space  IDA 2311698 RGD 
RenRatextracellular space located_inIEAUniProtKB:P06281 and ensembl:ENSMUSP000000921351600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatextracellular space located_inISORen1 (Mus musculus)1624291 PMID:10318840 and PMID:19293336RGDPMID:10318840 and PMID:19293336
RenRatextracellular space located_inIEAUniProtKB:P00797 and ensembl:ENSP000002721901600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatextracellular space is_active_inIBAMGI:97898 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RenRatextracellular space located_inIEAARBA:ARBA000277281600115GO_REF:0000117UniProtGO_REF:0000117
RenRatextracellular space is_active_inISOREN (Homo sapiens) and UniProtKB:P00797-11624291 PMID:12045255RGDPMID:12045255
RenRatextracellular space located_inISOREN (Homo sapiens)1624291 PMID:12045255 and PMID:26322847RGDPMID:12045255 and PMID:26322847
RenRatmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
RenRatmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function
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Original Reference(s)
RenRataspartic-type endopeptidase activity enablesIEAUniProtKB-KW:KW-00641600115GO_REF:0000043UniProtGO_REF:0000043
RenRataspartic-type endopeptidase activity enablesIEAEC:3.4.23.151600115GO_REF:0000003UniProtGO_REF:0000003
RenRataspartic-type endopeptidase activity enablesIEAInterPro:IPR001461 and InterPro:IPR0019691600115GO_REF:0000002InterProGO_REF:0000002
RenRataspartic-type endopeptidase activity enablesIEAUniProtKB:P00797 and ensembl:ENSP000002721901600115GO_REF:0000107EnsemblGO_REF:0000107
RenRataspartic-type endopeptidase activity enablesIBACGD:CAL0000197549 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
RenRataspartic-type endopeptidase activity enablesIEAUniProtKB:P06281 and ensembl:ENSMUSP000000921351600115GO_REF:0000107EnsemblGO_REF:0000107
RenRataspartic-type endopeptidase activity enablesISOREN (Homo sapiens) and UniProtKB:P00797-11624291 PMID:12045255RGDPMID:12045255
RenRataspartic-type endopeptidase activity enablesISOREN (Homo sapiens)1624291 PMID:20927107 more ...RGDPMID:20927107 more ...
RenRataspartic-type endopeptidase activity enablesISORen1 (Mus musculus)1624291 PMID:27649628 and PMID:6337154RGDPMID:27649628 and PMID:6337154
RenRatendopeptidase activity  IDA 2311700 RGD 
RenRatendopeptidase activity enablesISORen1 (Mus musculus)1624291 PMID:19293336RGDPMID:19293336
RenRatendopeptidase activity enablesIEAARBA:ARBA000281311600115GO_REF:0000117UniProtGO_REF:0000117
RenRatendopeptidase activity enablesIEAUniProtKB:P06281 and ensembl:ENSMUSP000000921351600115GO_REF:0000107EnsemblGO_REF:0000107
RenRathydrolase activity enablesIEAUniProtKB-KW:KW-03781600115GO_REF:0000043UniProtGO_REF:0000043
RenRatinsulin-like growth factor receptor binding  IDA 1581738 RGD 
RenRatpeptidase activity enablesISOREN (Homo sapiens)1624291 PMID:12045255RGDPMID:12045255
RenRatpeptidase activity enablesIEAUniProtKB:P00797 and ensembl:ENSP000002721901600115GO_REF:0000107EnsemblGO_REF:0000107
RenRatpeptidase activity enablesIEAUniProtKB-KW:KW-06451600115GO_REF:0000043UniProtGO_REF:0000043
RenRatprotein binding enablesISOREN (Homo sapiens)1624291UniProtKB:P01019 and PMID:20927107RGDPMID:20927107
RenRatsignaling receptor binding  IPIAtp6ap2 (Rattus norvegicus)5132599 RGD 
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RGD Manual Annotations


  
Object Symbol
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Source
Original Reference(s)
RenRatrenin-angiotensin cascade pathway   TAS 1581739 RGD 
RenRatrenin-angiotensin cascade pathway   IDA 1581651 RGD 
RenRatrenin-angiotensin cascade pathway   ISOREN (Homo sapiens)1581742 RGD 
RenRatrenin-angiotensin cascade pathway   IDA 1581738 RGD 

Imported Annotations - SMPDB

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Original Reference(s)
RenRatbenazepril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00145
RenRatcandesartan pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00158
RenRatcaptopril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00146
RenRatcilazapril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00147
RenRatenalapril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00148
RenRateprosartan pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00159
RenRatforasartsn pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00160
RenRatfosinopril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00149
RenRatirbesartan pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00161
RenRatlisinopril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00150
RenRatlosartan pharmacodynamics pathway   ISOREN (Homo sapiens)10402751 SMPDBSMP:00162
RenRatmoexipril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00151
RenRatolmesartan pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00163
RenRatperindopril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00152
RenRatquinapril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00153
RenRatramipril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00154
RenRatspirapril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00156
RenRattelmisartan pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00164
RenRattrandolapril pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00157
RenRatvalsartan pharmacodynamics pathway  ISOREN (Homo sapiens)10402751 SMPDBSMP:00165
1 to 20 of 20 rows

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RenRatrenin-angiotensin cascade pathway   IEA 6907045 KEGGrno:04614
1 to 20 of 20 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
RenRatabnormal kidney morphology exacerbatesIMP 7771614compared to wild typeRGD 
RenRatalbuminuria  IAGP 12802368 RGD 
RenRatdecreased body weight  IMP 7771614compared to wild typeRGD 
RenRatdecreased circulating bicarbonate level  IMP 7771614compared to wild typeRGD 
RenRatdecreased creatinine clearance  IMP 7771614compared to wild typeRGD 
RenRatdecreased mean systemic arterial blood pressure  IMP 7771614compared to wild typeRGD 
RenRatdecreased mean systemic arterial blood pressure sexual_dimorphismIMP 7771614compared to wild type maleRGD 
RenRatdecreased systemic arterial diastolic blood pressure  IMP 7771614compared to wild typeRGD 
RenRatdecreased systemic arterial diastolic blood pressure sexual_dimorphismIMP 7771614compared to wild type maleRGD 
RenRatdecreased systemic arterial systolic blood pressure sexual_dimorphismIMP 7771614compared to wild type maleRGD 
RenRatdecreased systemic arterial systolic blood pressure  IMP 7771614compared to wild typeRGD 
RenRatdecreased urine creatinine level  IMP 7771614compared to wild typeRGD 
RenRatdecreased urine protein level  IMP 7771614compared to wild typeRGD 
RenRatincreased blood urea nitrogen level  IMP 7771614 RGD 
RenRatincreased circulating alanine transaminase level  IMP 7771614compared to wild typeRGD 
RenRatincreased circulating creatinine level  IMP 7771614compared to wild typeRGD 
RenRatincreased heart rate  IMP 7771614compared to wild typeRGD 
RenRatincreased systemic arterial blood pressure  IAGP 61046 RGD 
RenRatincreased urine flow rate  IMP 7771614compared to wild typeRGD 
RenRatsalt-sensitive hypertension  IAGP 12802368 RGD 
1 to 20 of 20 rows

1 to 20 of 78 rows
#
Reference Title
Reference Citation
1. Strong association of a renin intronic dimorphism with essential hypertension. Ahmad U, etal., Hypertens Res. 2005 Apr;28(4):339-44.
2. Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension. Alderman MH, etal., N Engl J Med. 1991 Apr 18;324(16):1098-104.
3. Maternal and fetal plasma renin and dopamine-beta-hydroxylase activities in toxemic pregnancy. Annat G, etal., Obstet Gynecol. 1978 Aug;52(2):219-24.
4. [Hypertension-induced fibrosis: A balance story.] Azibani F, etal., Ann Cardiol Angeiol (Paris). 2012 May 25.
5. Subcellular localization of renin and kallikrein in rat kidney. Baggio B, etal., Ital J Biochem. 1975 May-Aug;24(3-4):199-206.
6. Molecular cloning of rat renin cDNA and its gene. Burnham CE, etal., Proc Natl Acad Sci U S A 1987 Aug;84(16):5605-9.
7. Renin released from mast cells activated by circulating MCP-1 initiates the microvascular phase of the systemic inflammation of alveolar hypoxia. Chao J, etal., Am J Physiol Heart Circ Physiol. 2011 Dec;301(6):H2264-70. Epub 2011 Sep 30.
8. Adipogenic differentiation of adipose tissue-derived human mesenchymal stem cells: effect of gastric bypass surgery. Chen JG, etal., Surg Endosc. 2012 May 31.
9. Renin inhibitor aliskiren exerts neuroprotection against amyloid beta-peptide toxicity in rat cortical neurons. Chen SD, etal., Neurochem Int. 2012 May 17;61(3):369-377.
10. Implications of Plasma Renin Activity and Plasma Aldosterone Concentration in Critically Ill Patients with Septic Shock. Chung KS, etal., Korean J Crit Care Med. 2017 May;32(2):142-153. doi: 10.4266/kjccm.2017.00094. Epub 2017 May 31.
11. An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria. Clausmeyer S, etal., Circ Res 1999 Feb 19;84(3):337-44.
12. First evidence of aryl hydrocarbon receptor as a druggable target in hypertension induced by chronic intermittent hypoxia. Coelho NR, etal., Pharmacol Res. 2020 Sep;159:104869. doi: 10.1016/j.phrs.2020.104869. Epub 2020 May 19.
13. Chronic depression symptoms desensitize renin activity to protect against volume-loading hypertension in Blacks: The SABPA study. De Vos AC, etal., Physiol Behav. 2018 Oct 1;194:474-480. doi: 10.1016/j.physbeh.2018.06.038. Epub 2018 Jun 28.
14. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats. Dubay C, etal., Nat Genet 1993 Apr;3(4):354-7
15. Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang. Feng Q, etal., Biosci Rep. 2018 Jun 27;38(3). pii: BSR20171522. doi: 10.1042/BSR20171522. Print 2018 Jun 29.
16. Structure of the rat renin gene. Fukamizu A, etal., J Mol Biol 1988 May 20;201(2):443-50.
17. Endogenous or overexpressed cGMP-dependent protein kinases inhibit cAMP-dependent renin release from rat isolated perfused kidney, microdissected glomeruli, and isolated juxtaglomerular cells. Gambaryan S, etal., Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):9003-8.
18. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
19. Renin as a Marker of Tissue-Perfusion and Prognosis in Critically Ill Patients. Gleeson PJ, etal., Crit Care Med. 2019 Feb;47(2):152-158. doi: 10.1097/CCM.0000000000003544.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
1 to 20 of 78 rows
PMID:4289389   PMID:4322712   PMID:4330891   PMID:4360430   PMID:8490598   PMID:9933256   PMID:10318840   PMID:10617578   PMID:10807585   PMID:11145610   PMID:11702851   PMID:12045255  
PMID:12469222   PMID:12477932   PMID:12511427   PMID:12560203   PMID:14583438   PMID:15342908   PMID:15489334   PMID:15792957   PMID:15870381   PMID:17440033   PMID:17670863   PMID:18198281  
PMID:18202178   PMID:18413493   PMID:18426992   PMID:18509102   PMID:18653711   PMID:18671756   PMID:18782187   PMID:19050177   PMID:19139376   PMID:19171793   PMID:19261739   PMID:19293336  
PMID:19841286   PMID:19861503   PMID:20683339   PMID:20852041   PMID:21331057   PMID:21483231   PMID:21484732   PMID:21521778   PMID:21752621   PMID:21865264   PMID:22020141   PMID:23460292  
PMID:24119481   PMID:24204720   PMID:24436324   PMID:24473199   PMID:25394830   PMID:25707593   PMID:25766467   PMID:25767135   PMID:26256830   PMID:26322847   PMID:26660905   PMID:27090360  
PMID:27443990   PMID:27545826   PMID:28161727   PMID:28715805   PMID:29521603   PMID:30110572   PMID:30247805   PMID:34841988  



Ren
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81347,348,312 - 47,359,539 (+)NCBIGRCr8
mRatBN7.21344,796,260 - 44,807,491 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1344,796,091 - 44,807,489 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1347,406,270 - 47,416,579 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01348,694,375 - 48,704,684 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01345,952,438 - 45,963,417 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01350,502,724 - 50,513,953 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01355,555,583 - 55,566,812 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41346,262,936 - 46,275,213 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11346,277,000 - 46,288,249 (+)NCBI
Celera1345,129,122 - 45,139,889 (+)NCBICelera
RH 3.4 Map13170.9RGD
Cytogenetic Map13q13NCBI
REN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381204,154,819 - 204,166,337 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1204,154,819 - 204,190,324 (-)EnsemblGRCh38hg38GRCh38
GRCh371204,123,947 - 204,135,465 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361202,390,571 - 202,402,088 (-)NCBINCBI36Build 36hg18NCBI36
Build 341200,855,604 - 200,867,122NCBI
Celera1177,259,194 - 177,270,715 (-)NCBICelera
Cytogenetic Map1q32.1NCBI
HuRef1175,289,120 - 175,300,481 (-)NCBIHuRef
CHM1_11205,547,624 - 205,559,145 (-)NCBICHM1_1
T2T-CHM13v2.01203,418,967 - 203,430,485 (-)NCBIT2T-CHM13v2.0
Ren1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391133,278,412 - 133,288,058 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1133,278,248 - 133,288,063 (+)EnsemblGRCm39 Ensembl
GRCm381133,350,674 - 133,360,320 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1133,350,510 - 133,360,325 (+)EnsemblGRCm38mm10GRCm38
MGSCv371135,247,251 - 135,256,894 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361135,178,238 - 135,187,863 (+)NCBIMGSCv36mm8
Celera1135,963,151 - 135,972,794 (+)NCBICelera
Cytogenetic Map1E4NCBI
cM Map157.91NCBI
Ren
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540640,016,630 - 40,026,286 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540640,016,624 - 40,026,286 (-)NCBIChiLan1.0ChiLan1.0
REN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2145,210,086 - 45,221,659 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1145,175,312 - 45,186,915 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01179,757,653 - 179,769,530 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11184,045,917 - 184,057,431 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1184,046,117 - 184,057,393 (-)Ensemblpanpan1.1panPan2
REN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.138744,540 - 766,998 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl38744,614 - 755,012 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha38840,126 - 850,501 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.038740,693 - 762,325 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl38740,767 - 751,204 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.138736,523 - 746,891 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0381,127,902 - 1,138,260 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0381,328,102 - 1,338,487 (-)NCBIUU_Cfam_GSD_1.0
Ren
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934471,363,409 - 71,373,041 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936567598,048 - 607,497 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936567598,044 - 607,628 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
REN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl964,809,146 - 64,822,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1964,809,143 - 64,822,605 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2971,147,542 - 71,151,808 (-)NCBISscrofa10.2Sscrofa10.2susScr3
REN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12525,159,816 - 25,193,620 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2525,183,037 - 25,193,420 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605525,943,204 - 25,954,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ren
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248076,817,195 - 6,827,462 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248076,817,472 - 6,827,374 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Ren
70 total Variants

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000003951
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 36 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133466346187525369Rat
9589141Insul28Insulin level QTL 2810.820.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)13931346554313465Rat
12879436Bp395Blood pressure QTL 395arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)134463918245700190Rat
6893344Cm79Cardiac mass QTL 791.50.04heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)134372077062022792Rat
70220Bp55Blood pressure QTL 555.75arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)133737450982374509Rat
61391Bp5Blood pressure QTL 55.6arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)132230187567301875Rat
4889861Pur29Proteinuria QTL 2913.80.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)133741558480753406Rat
1300163Cardf1Cardiac cell morphology QTL 14.18aorta morphology trait (VT:0000272)artery lesion measurement (CMO:0000975)131192944945417941Rat
2317040Aia21Adjuvant induced arthritis QTL 212.75joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)13983154154831541Rat
631645Bp121Blood pressure QTL 1213.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131491565559915655Rat

1 to 10 of 36 rows
D13Uwm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.11346,283,977 - 46,284,161RGD
RH 3.4 Map13173.5UniSTS
Cytogenetic Map13q13UniSTS
D13Wox5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81347,354,258 - 47,354,444 (+)Marker Load Pipeline
Rnor_5.01355,560,677 - 55,560,862NCBIRnor5.0
RGSC_v3.41346,269,934 - 46,270,118RGDRGSC3.4
RGSC_v3.11346,283,977 - 46,284,161RGD
RH 3.4 Map13173.5RGD
RH 3.4 Map13173.5UniSTS
RH 2.0 Map13376.9RGD
Cytogenetic Map13q13UniSTS
D13Arb7  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81347,354,143 - 47,354,458 (+)Marker Load Pipeline
mRatBN7.21344,802,093 - 44,802,410 (-)MAPPERmRatBN7.2
Rnor_6.01350,507,805 - 50,508,121NCBIRnor6.0
Rnor_5.01355,560,664 - 55,560,980UniSTSRnor5.0
RGSC_v3.41346,269,815 - 46,270,132RGDRGSC3.4
RGSC_v3.41346,269,816 - 46,270,132UniSTSRGSC3.4
RGSC_v3.11346,283,858 - 46,284,175RGD
Celera1345,134,496 - 45,134,808UniSTS
RH 3.4 Map13182.9RGD
RH 3.4 Map13182.9UniSTS
SHRSP x BN Map1314.7498UniSTS
SHRSP x BN Map1314.7498RGD
Cytogenetic Map13q13UniSTS
RH94507  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81347,347,944 - 47,348,134 (+)Marker Load Pipeline
mRatBN7.21344,795,892 - 44,796,082 (-)MAPPERmRatBN7.2
Rnor_6.01350,514,131 - 50,514,320NCBIRnor6.0
Rnor_5.01355,566,990 - 55,567,179UniSTSRnor5.0
RGSC_v3.41346,262,569 - 46,262,758UniSTSRGSC3.4
Celera1345,128,755 - 45,128,944UniSTS
RH 3.4 Map13170.9UniSTS
Cytogenetic Map13q13UniSTS
RH138392  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21344,807,241 - 44,807,417 (-)MAPPERmRatBN7.2
Rnor_6.01350,502,798 - 50,502,973NCBIRnor6.0
Rnor_5.01355,555,657 - 55,555,832UniSTSRnor5.0
RGSC_v3.41346,274,964 - 46,275,139UniSTSRGSC3.4
Celera1345,139,640 - 45,139,815UniSTS
RH 3.4 Map13181.6UniSTS
Cytogenetic Map13q13UniSTS


The following Strains have been annotated to Ren
SS.BN-(D13Hmgc64-RN34_13048990782)/Mcwi     SS.BN-(D13Rat20-D13Rat127)/Mcwi    


This gene Ren is modified in the following models/strains:
SS-Renem1Mcwi     SS-Renem1Mcwi+/-     SS-Renem1Mcwi-/-    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
5 1 6 90 87 79 59 9 59 3 140 30 73 45 60 20



Ensembl Acc Id: ENSRNOT00000003951   ⟹   ENSRNOP00000003951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,796,091 - 44,807,487 (+)Ensembl
Rnor_6.0 Ensembl1350,502,724 - 50,514,151 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000076747   ⟹   ENSRNOP00000067953
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,800,297 - 44,801,191 (+)Ensembl
Rnor_6.0 Ensembl1350,509,024 - 50,509,916 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097884   ⟹   ENSRNOP00000094943
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1344,800,741 - 44,807,489 (+)Ensembl
RefSeq Acc Id: NM_012642   ⟹   NP_036774
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81347,348,312 - 47,359,539 (+)NCBI
mRatBN7.21344,796,260 - 44,807,491 (+)NCBI
Rnor_6.01350,502,724 - 50,513,953 (-)NCBI
Rnor_5.01355,555,583 - 55,566,812 (-)NCBI
RGSC_v3.41346,262,936 - 46,275,213 (+)RGD
Celera1345,129,122 - 45,139,889 (+)RGD
Sequence:
RefSeq Acc Id: NP_036774   ⟸   NM_012642
- Peptide Label: precursor
- UniProtKB: Q63497 (UniProtKB/Swiss-Prot),   P08424 (UniProtKB/Swiss-Prot),   A6IC75 (UniProtKB/TrEMBL),   A6IC76 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000003951   ⟸   ENSRNOT00000003951
Ensembl Acc Id: ENSRNOP00000067953   ⟸   ENSRNOT00000076747
Ensembl Acc Id: ENSRNOP00000094943   ⟸   ENSRNOT00000097884
Peptidase A1

Name Modeler Protein Id AA Range Protein Structure Video
AF-P08424-F1-model_v2 AlphaFold P08424 1-402 view protein structure  
Prorenin pdb 4amt P08424 27-402 view protein structure view video
Renin1 pdb 2x0b P08424 65-402 view protein structure view video


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 32 of 32 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-18289 BioCyc
Ensembl Genes ENSRNOG00000002937 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000003951 ENTREZGENE
  ENSRNOT00000003951.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.70.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7126969 IMAGE-MGC_LOAD
InterPro Aspartic_peptidase_A1 UniProtKB/Swiss-Prot
  Aspartic_peptidase_AS UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
  Peptidase_aspartic_dom_sf UniProtKB/Swiss-Prot
  Renin-like_dom UniProtKB/Swiss-Prot
KEGG Report rno:24715 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93560 IMAGE-MGC_LOAD
NCBI Gene 24715 ENTREZGENE
PANTHER PTHR47966 UniProtKB/Swiss-Prot
  RENIN UniProtKB/Swiss-Prot
Pfam Asp UniProtKB/Swiss-Prot
PharmGKB REN RGD
PhenoGen Ren PhenoGen
PRINTS PEPSIN UniProtKB/Swiss-Prot
PROSITE ASP_PROTEASE UniProtKB/Swiss-Prot
  PEPTIDASE_A1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000002937 RatGTEx
Superfamily-SCOP SSF50630 UniProtKB/Swiss-Prot
UniProt A0A8I6ANY3_RAT UniProtKB/TrEMBL
  A6IC75 ENTREZGENE, UniProtKB/TrEMBL
  A6IC76 ENTREZGENE, UniProtKB/TrEMBL
  P08424 ENTREZGENE
  Q63497 ENTREZGENE
  Q9JIE2_RAT UniProtKB/TrEMBL
  RENI_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q63497 UniProtKB/Swiss-Prot
1 to 32 of 32 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-24 Ren  renin  Ren1  renin 1 structural  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Ren1  renin 1 structural  Ren1  renin 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Ren1  renin 1  Ren  Renin  Symbol and Name updated 629477 APPROVED
2002-06-10 Ren  Renin      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_disease affects heart mass independent of blood pressure 1357231
gene_expression expressed in the juxtaglomerular apparatus 625761
gene_regulation expression in the juxtaglomerular apparatus during low-salt diet is greatly reduced by a direct feedback inhibition through ANG II 625761