Psmc2 (proteasome 26S subunit, ATPase 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Psmc2 (proteasome 26S subunit, ATPase 2) Rattus norvegicus
Analyze
Symbol: Psmc2
Name: proteasome 26S subunit, ATPase 2
RGD ID: 3428
Description: Enables TBP-class protein binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in dendritic spine. Orthologous to human PSMC2 (proteasome 26S subunit, ATPase 2); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 26S protease regulatory subunit 7; 26S proteasome AAA-ATPase subunit RPT1; 26S proteasome regulatory subunit 7; MSS1; proteasome (prosome, macropain) 26S subunit, ATPase 2; proteasome 26S subunit ATPase 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,148,080 - 14,162,390 (-)NCBIGRCr8
mRatBN7.2413,255,850 - 13,270,160 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,255,856 - 13,270,185 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx418,401,118 - 18,415,400 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,215,883 - 14,230,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,586,755 - 12,601,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,867,132 - 9,881,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,867,101 - 9,881,484 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,868,269 - 9,882,520 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,704,100 - 8,718,351 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.148,704,099 - 8,718,351 (-)NCBI
Celera48,847,110 - 8,861,246 (-)NCBICelera
Cytogenetic Map4q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-nitrofluorene  (EXP)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
Brodifacoum  (EXP)
butyric acid  (ISO)
cadmium dichloride  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (EXP,ISO)
chromium(6+)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dichlorine  (EXP)
dicrotophos  (ISO)
diethylstilbestrol  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
gentamycin  (EXP)
glyphosate  (EXP)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
hypochlorous acid  (ISO)
imidacloprid  (EXP)
ivermectin  (ISO)
ketoconazole  (ISO)
lead(0)  (ISO)
lovastatin  (ISO)
Mesaconitine  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
monocrotaline  (EXP)
monosodium L-glutamate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nicotine  (ISO)
Nonylphenol  (EXP)
ozone  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
Propiverine  (EXP)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulindac  (EXP)
sulindac sulfide  (ISO)
sunitinib  (ISO)
T-2 toxin  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thiabendazole  (EXP)
trichostatin A  (ISO)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)
warfarin  (ISO)
zearalenone  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Activity-dependent dynamics and sequestration of proteasomes in dendritic spines. Bingol B and Schuman EM, Nature. 2006 Jun 29;441(7097):1144-8.
2. Participation of the 26S proteasome in the regulation of progesterone receptor concentrations in the rat brain. Camacho-Arroyo I, etal., Neuroendocrinology 2002 Nov;76(5):267-71.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Structures of the rat proteasomal ATPases: determination of highly conserved structural motifs and rules for their spacing. Makino Y, etal., Biochem Biophys Res Commun 1996 Mar 27;220(3):1049-54.
6. Multiple mammalian proteasomal ATPases, but not proteasome itself, are associated with TATA-binding protein and a novel transcriptional activator, TIP120. Makino Y, etal., Genes Cells. 1999 Sep;4(9):529-39.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
13. Tissue and cell distribution of a mammalian proteasomal ATPase, MSS1, and its complex formation with the basal transcription factors. Yanagi S, etal., Biochem Biophys Res Commun. 2000 Dec 20;279(2):568-73.
Additional References at PubMed
PMID:9295362   PMID:9533861   PMID:9688553   PMID:16210410   PMID:16857966   PMID:17323924   PMID:18419753   PMID:19638347   PMID:19946888   PMID:21630459   PMID:22078707   PMID:22871113  
PMID:30053369   PMID:31904090   PMID:33450132  


Genomics

Comparative Map Data
Psmc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,148,080 - 14,162,390 (-)NCBIGRCr8
mRatBN7.2413,255,850 - 13,270,160 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,255,856 - 13,270,185 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx418,401,118 - 18,415,400 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,215,883 - 14,230,158 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,586,755 - 12,601,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,867,132 - 9,881,383 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,867,101 - 9,881,484 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.049,868,269 - 9,882,520 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.448,704,100 - 8,718,351 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.148,704,099 - 8,718,351 (-)NCBI
Celera48,847,110 - 8,861,246 (-)NCBICelera
Cytogenetic Map4q11NCBI
PSMC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387103,347,524 - 103,369,395 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7103,328,570 - 103,370,346 (+)EnsemblGRCh38hg38GRCh38
GRCh377102,987,971 - 103,009,842 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,775,325 - 102,795,892 (+)NCBINCBI36Build 36hg18NCBI36
Build 347102,582,039 - 102,602,606NCBI
Celera797,795,300 - 97,815,873 (+)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef797,350,323 - 97,372,344 (+)NCBIHuRef
CHM1_17102,920,963 - 102,943,153 (+)NCBICHM1_1
T2T-CHM13v2.07104,661,962 - 104,683,844 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27102,348,337 - 102,370,208 (+)NCBI
Psmc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39521,990,273 - 22,008,785 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl521,990,281 - 22,008,785 (+)EnsemblGRCm39 Ensembl
GRCm38521,785,275 - 21,803,787 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,785,283 - 21,803,787 (+)EnsemblGRCm38mm10GRCm38
MGSCv37521,291,101 - 21,309,602 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36521,297,107 - 21,315,608 (+)NCBIMGSCv36mm8
Celera518,756,208 - 18,774,395 (+)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.97NCBI
Psmc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,341,065 - 8,356,148 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554108,341,218 - 8,355,515 (+)NCBIChiLan1.0ChiLan1.0
PSMC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26140,201,706 - 140,227,300 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17188,473,396 - 188,497,270 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0795,338,743 - 95,359,353 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17108,083,019 - 108,103,595 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,083,203 - 108,103,494 (+)Ensemblpanpan1.1panPan2
PSMC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,845,593 - 16,859,010 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,845,594 - 16,858,911 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1816,488,537 - 16,501,956 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01817,136,145 - 17,149,599 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1817,136,146 - 17,149,526 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,900,975 - 16,914,588 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,839,559 - 16,853,208 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01817,107,769 - 17,121,439 (-)NCBIUU_Cfam_GSD_1.0
Psmc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511859,026,969 - 59,043,987 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647920,148,632 - 20,168,130 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647920,150,738 - 20,167,765 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PSMC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,362,599 - 103,376,343 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19103,362,684 - 103,376,048 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29113,971,194 - 113,984,560 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PSMC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,323,691 - 72,341,647 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,323,803 - 72,341,488 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604231,660,968 - 31,679,446 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Psmc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473926,001,871 - 26,016,040 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473926,001,871 - 26,015,633 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Psmc2
160 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:49
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000016450
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat

Markers in Region
RH142410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,255,880 - 13,256,039 (+)MAPPERmRatBN7.2
Rnor_6.049,867,162 - 9,867,320NCBIRnor6.0
Rnor_5.049,868,299 - 9,868,457UniSTSRnor5.0
RGSC_v3.448,704,130 - 8,704,288UniSTSRGSC3.4
Celera48,847,140 - 8,847,298UniSTS
Cytogenetic Map4q11UniSTS
RH142567  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,263,934 - 13,264,045 (+)MAPPERmRatBN7.2
Rnor_6.049,875,216 - 9,875,326NCBIRnor6.0
Rnor_5.049,876,353 - 9,876,463UniSTSRnor5.0
RGSC_v3.448,712,184 - 8,712,294UniSTSRGSC3.4
Celera48,855,194 - 8,855,304UniSTS
Cytogenetic Map4q11UniSTS
RH140841  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2413,255,879 - 13,256,072 (+)MAPPERmRatBN7.2
Rnor_6.049,867,161 - 9,867,353NCBIRnor6.0
Rnor_5.049,868,298 - 9,868,490UniSTSRnor5.0
RGSC_v3.448,704,129 - 8,704,321UniSTSRGSC3.4
Celera48,847,139 - 8,847,331UniSTS
RH 3.4 Map440.0UniSTS
Cytogenetic Map4q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000016450   ⟹   ENSRNOP00000016450
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl413,255,856 - 13,270,185 (-)Ensembl
Rnor_6.0 Ensembl49,867,101 - 9,881,484 (-)Ensembl
RefSeq Acc Id: NM_033236   ⟹   NP_150239
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,148,080 - 14,162,390 (-)NCBI
mRatBN7.2413,255,850 - 13,270,160 (-)NCBI
Rnor_6.049,867,132 - 9,881,383 (-)NCBI
Rnor_5.049,868,269 - 9,882,520 (-)NCBI
RGSC_v3.448,704,100 - 8,718,351 (-)RGD
Celera48,847,110 - 8,861,246 (-)RGD
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_150239   ⟸   NM_033236
- UniProtKB: Q6P7R9 (UniProtKB/Swiss-Prot),   Q63347 (UniProtKB/Swiss-Prot),   Q62690 (UniProtKB/Swiss-Prot),   G3V7L6 (UniProtKB/TrEMBL),   A6K5A1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000016450   ⟸   ENSRNOT00000016450
Protein Domains
AAA ATPase AAA+ lid   AAA+ ATPase   ATPase AAA-type core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63347-F1-model_v2 AlphaFold Q63347 1-433 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692805
Promoter ID:EPDNEW_R3329
Type:multiple initiation site
Name:Psmc2_1
Description:proteasome 26S subunit, ATPase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.049,881,413 - 9,881,473EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3428 AgrOrtholog
BioCyc Gene G2FUF-45988 BioCyc
Ensembl Genes ENSRNOG00000012026 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016450 ENTREZGENE
  ENSRNOT00000016450.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6918933 IMAGE-MGC_LOAD
InterPro AAA+_ATPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ATPase_AAA_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRS7-like_OB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25581 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72754 IMAGE-MGC_LOAD
NCBI Gene 25581 ENTREZGENE
PANTHER 26S PROTEASOME REGULATORY SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23073:SF13 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AAA_lid_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRS7_OB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Psmc2 PhenoGen
PROSITE AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012026 RatGTEx
SMART AAA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6K5A1 ENTREZGENE, UniProtKB/TrEMBL
  A6K5A2_RAT UniProtKB/TrEMBL
  A6K5A3_RAT UniProtKB/TrEMBL
  A6K5A4_RAT UniProtKB/TrEMBL
  G3V7L6 ENTREZGENE, UniProtKB/TrEMBL
  PRS7_RAT UniProtKB/Swiss-Prot
  Q62690 ENTREZGENE
  Q63347 ENTREZGENE
  Q6P7R9 ENTREZGENE
UniProt Secondary Q62690 UniProtKB/Swiss-Prot
  Q6P7R9 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-19 Psmc2  proteasome 26S subunit, ATPase 2  Psmc2  proteasome (prosome, macropain) 26S subunit, ATPase 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Psmc2  Proteasome (prosome, macropain) 26S subunit, ATPase      Symbol and Name status set to approved 70586 APPROVED