Prkca (protein kinase C, alpha) - Rat Genome Database

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Gene: Prkca (protein kinase C, alpha) Rattus norvegicus
Analyze
Symbol: Prkca
Name: protein kinase C, alpha
RGD ID: 3395
Description: Enables calcium,diacylglycerol-dependent serine/threonine kinase activity and signaling receptor binding activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; protein phosphorylation; and response to corticosterone. Located in cytosol and perinuclear region of cytoplasm. Part of protein-containing complex. Used to study hypertension. Biomarker of brain ischemia; congestive heart failure; and ischemia. Human ortholog(s) of this gene implicated in dilated cardiomyopathy; high grade glioma (multiple); large cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human PRKCA (protein kinase C alpha); PARTICIPATES IN eicosanoid signaling pathway; endothelin signaling pathway; Fc epsilon receptor mediated signaling pathway; INTERACTS WITH (S)-nicotine; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: PKC-A; PKC-alpha; Pkca; protein kinase C alpha type
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau3 Pia10 Cia5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,388,991 - 93,787,617 (-)NCBIGRCr8
mRatBN7.21092,889,390 - 93,288,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,894,012 - 93,288,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,947,717 - 98,345,380 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,410,758 - 97,808,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,819,189 - 93,215,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01096,186,509 - 96,585,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,191,133 - 96,584,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,919,013 - 96,311,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,367,196 - 97,638,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,382,023 - 97,632,491 (-)NCBI
Celera1091,557,626 - 91,951,823 (-)NCBICelera
RH 3.4 Map101035.79RGD
Cytogenetic Map10q32.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
PrkcaRatbrain ischemia  IEP 2293301associated with Subarachnoid Hemorrhage and protein:increased phosphorylation:cerebral arteryRGD 
PrkcaRatBreast Neoplasms  ISOPRKCA (Homo sapiens)2292446 RGD 
PrkcaRatBreast Neoplasms  ISOPRKCA (Homo sapiens)2292458protein:decreased expression:breastRGD 
PrkcaRatBreast Neoplasms  ISOPRKCA (Homo sapiens)2292463 RGD 
PrkcaRatCardiomegaly  IAGP 1581271 RGD 
PrkcaRatchordoid glioma  ISOPRKCA (Homo sapiens)13782058DNA:mutation:cds:c.1387G>C and p.D463H(human)RGD 
PrkcaRatcongestive heart failure  IEP 2292480protein:increased expression and increased phosphorylation:heart left ventricleRGD 
PrkcaRatdilated cardiomyopathy  ISOPRKCA (Homo sapiens)1581274 RGD 
PrkcaRatductal carcinoma in situ  ISOPRKCA (Homo sapiens)2292458protein:decreased expression:breastRGD 
PrkcaRatendometrial carcinoma  ISOPRKCA (Homo sapiens)2292462 RGD 
PrkcaRathigh grade glioma  ISOPRKCA (Homo sapiens)11087038DNA:gene fusion: :RGD 
PrkcaRathypertension  IAGP 1581271 RGD 
PrkcaRatischemia  IEP 2292478 RGD 
PrkcaRatlarge cell carcinoma  ISOPRKCA (Homo sapiens)2292463 RGD 
PrkcaRatLeft Ventricular Hypertrophy  IDA 1581273 RGD 
PrkcaRatovarian cancer  ISOPRKCA (Homo sapiens)2298671 RGD 
PrkcaRatovarian carcinoma severityISOPRKCA (Homo sapiens)2292460 RGD 
PrkcaRatPituitary Neoplasms  ISOPRKCA (Homo sapiens)1601471DNA:point mutation:somatic:D294GRGD 
PrkcaRatprostate carcinoma  ISOPRKCA (Homo sapiens)2292463 RGD 
PrkcaRatReperfusion Injury  IMP 2292474 RGD 
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Original Reference(s)
PrkcaRatCardiomegaly  ISOPRKCA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21565836
PrkcaRatExperimental Diabetes Mellitus  ISOPRKCA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12198386
PrkcaRatIntestinal Neoplasms  ISOPRKCA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11983831
PrkcaRatmetabolic dysfunction-associated steatotic liver disease  ISOPRKCA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29341352
PrkcaRatnephrogenic diabetes insipidus  ISOPRKCA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25006961
PrkcaRatoccupational asthma  ISOPRKCA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27504716
PrkcaRatPolyuria  ISOPRKCA (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25006961

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Original Reference(s)
PrkcaRat(1->4)-beta-D-glucan multiple interactionsISOPrkca (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of PRKCA mRNACTDPMID:36331819
PrkcaRat(5Z,8Z,11Z,13E)-15-HETE multiple interactionsISOPRKCA (Homo sapiens)648046415-hydroxy-5 more ...CTDPMID:15613483
PrkcaRat(5Z,8Z,11Z,13E)-15-HETE multiple interactionsISOPrkca (Mus musculus)6480464calphostin C inhibits the reaction [15-hydroxy-5 more ...CTDPMID:15451026
PrkcaRat(5Z,8Z,11Z,13E)-15-HETE affects localizationISOPRKCA (Homo sapiens)648046415-hydroxy-5 more ...CTDPMID:15613483
PrkcaRat(5Z,8Z,11Z,13E)-15-HETE increases activityISOPrkca (Mus musculus)648046415-hydroxy-5 more ...CTDPMID:15451026
PrkcaRat(9R)-9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20-dione affects response to substanceISOPrkca (Mus musculus)6480464PRKCA affects the susceptibility to ruboxistaurinCTDPMID:19556521
PrkcaRat(S)-naringenin multiple interactionsISOPRKCA (Homo sapiens)6480464[naringenin co-treated with bisphenol A] results in increased expression of PRKCA mRNA more ...CTDPMID:25866363 and PMID:36235125
PrkcaRat(S)-nicotine increases activityISOPRKCA (Homo sapiens)6480464Nicotine results in increased activity of PRKCA proteinCTDPMID:12421819
PrkcaRat(S)-nicotine increases expressionEXP 6480464Nicotine results in increased expression of PRKCA mRNACTDPMID:20426880
PrkcaRat1,2-dimethylhydrazine decreases expressionISOPrkca (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of PRKCA mRNACTDPMID:22206623 and PMID:26388957
PrkcaRat1,2-dimethylhydrazine multiple interactionsISOPrkca (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of PRKCA mRNA]CTDPMID:22206623
PrkcaRat1-(5-isoquinolinesulfonyl)-2-methylpiperazine multiple interactionsEXP 64804641-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Heptachlor affects the localization of PRKCA protein] and 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCA protein]CTDPMID:14678745
PrkcaRat1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile increases expressionEXP 6480464Citalopram results in increased expression of PRKCA mRNACTDPMID:28467792
PrkcaRat17alpha-ethynylestradiol affects expressionISOPrkca (Mus musculus)6480464Ethinyl Estradiol affects the expression of PRKCA mRNACTDPMID:17555576
PrkcaRat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of PRKCA mRNACTDPMID:29097150
PrkcaRat17beta-estradiol multiple interactionsISOPRKCA (Homo sapiens)6480464[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PRKCA mRNA more ...CTDPMID:19619570 and PMID:23000059
PrkcaRat17beta-estradiol multiple interactionsEXP 6480464[bisphenol A co-treated with Estradiol] results in decreased expression of PRKCA mRNACTDPMID:26496021
PrkcaRat17beta-estradiol increases phosphorylationISOPRKCA (Homo sapiens)6480464Estradiol results in increased phosphorylation of PRKCA proteinCTDPMID:23000059
PrkcaRat17beta-estradiol decreases activityISOPRKCA (Homo sapiens)6480464Estradiol results in decreased activity of PRKCA proteinCTDPMID:8946564
PrkcaRat17beta-estradiol increases expressionISOPRKCA (Homo sapiens)6480464Estradiol results in increased expression of PRKCA mRNACTDPMID:19619570

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Biological Process
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Original Reference(s)
PrkcaRatangiogenesis involved_inIEAUniProtKB-KW:KW-00371600115GO_REF:0000043UniProtGO_REF:0000043
PrkcaRatapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
PrkcaRatcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
PrkcaRatcell population proliferation acts_upstream_ofISOPrkca (Mus musculus)1624291MGI:88039 PMID:17956267RGDPMID:17956267
PrkcaRatcellular response to carbohydrate stimulus acts_upstream_of_or_withinISOPrkca (Mus musculus)1624291 PMID:16585392RGDPMID:16585392
PrkcaRatcentral nervous system neuron axonogenesis  IMP 2293300 RGD 
PrkcaRatchondrocyte differentiation acts_upstream_of_or_withinISOPrkca (Mus musculus)1624291 PMID:17644814RGDPMID:17644814
PrkcaRatchromatin remodeling involved_inIEAGO:00354031600115GO_REF:0000108GOCGO_REF:0000108
PrkcaRatdesmosome assembly involved_inISOPRKCA (Homo sapiens)1624291 PMID:18474624RGDPMID:18474624
PrkcaRatdesmosome assembly involved_inIEAUniProtKB:P17252 and ensembl:ENSP000004086951600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcaRatestablishment of protein localization involved_inTAS 8553901PMID:15269270UniProt 
PrkcaRatinduction of positive chemotaxis acts_upstream_of_or_withinISOPrkca (Mus musculus)1624291MGI:3029711 PMID:12928424RGDPMID:12928424
PrkcaRatintracellular calcium ion homeostasis acts_upstream_of_or_withinISOPrkca (Mus musculus)1624291MGI:3037088 PMID:14966518RGDPMID:14966518
PrkcaRatintracellular signal transduction  IDA 628493 RGD 
PrkcaRatintracellular signal transduction involved_inIBAFB:FBgn0003744 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
PrkcaRatintrinsic apoptotic signaling pathway acts_upstream_of_or_withinISOPrkca (Mus musculus)1624291MGI:3029711 PMID:12928424RGDPMID:12928424
PrkcaRatlearning or memory  IMP 2293299 RGD 
PrkcaRatmuscle cell cellular homeostasis acts_upstream_of_or_withinISOPrkca (Mus musculus)1624291MGI:3037088 PMID:14966518RGDPMID:14966518
PrkcaRatnegative regulation of cell population proliferation acts_upstream_of_or_withinISOPrkca (Mus musculus)1624291MGI:88039 PMID:17956267RGDPMID:17956267
PrkcaRatnegative regulation of cytokine production involved in inflammatory response acts_upstream_of_or_withinISOPrkca (Mus musculus)1624291 PMID:21083424RGDPMID:21083424
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Cellular Component
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PrkcaRatalphav-beta3 integrin-PKCalpha complex part_ofISOPrkca (Mus musculus)1624291 PMID:16014375RGDPMID:16014375
PrkcaRatapical part of cell located_inISOPrkca (Mus musculus)1624291 PMID:23863479RGDPMID:23863479
PrkcaRataxon located_inISOPrkca (Mus musculus)1624291 PMID:18265009RGDPMID:18265009
PrkcaRatcalyx of Held is_active_inISOPrkca (Mus musculus)1624291 PMID:21658591RGDPMID:21658591
PrkcaRatciliary basal body is_active_inISOPRKCA (Homo sapiens)1624291 PMID:33934390RGDPMID:33934390
PrkcaRatciliary basal body is_active_inIEAUniProtKB:P17252 and ensembl:ENSP000004086951600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcaRatcone photoreceptor outer segment located_inISOPrkca (Mus musculus)1624291 PMID:10813773RGDPMID:10813773
PrkcaRatcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
PrkcaRatcytoplasm located_inISOPrkca (Mus musculus)1624291 PMID:10882525 more ...RGDPMID:10882525 more ...
PrkcaRatcytoplasm located_inISOPRKCA (Homo sapiens)1624291 PMID:15632189 and PMID:23990668RGDPMID:15632189 and PMID:23990668
PrkcaRatcytoplasm located_inISSUniProtKB:P172521600115GO_REF:0000024UniProtGO_REF:0000024
PrkcaRatcytoplasm located_inIEAUniProtKB:P17252 and ensembl:ENSP000004086951600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcaRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
PrkcaRatcytosol located_inIEAUniProtKB:L7RSM7 and ensembl:ENSP000004086951600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcaRatcytosol located_inIDA 8554603PMID:11864993UniProt 
PrkcaRatcytosol located_inIEAARBA:ARBA000292431600115GO_REF:0000117UniProtGO_REF:0000117
PrkcaRatcytosol located_inISOPRKCA (Homo sapiens)1624291 PMID:17983652RGDGO_REF:0000052 and PMID:17983652
PrkcaRatcytosol is_active_inISOPrkca (Mus musculus)1624291 PMID:21083424RGDPMID:21083424
PrkcaRatcytosol located_inIEAUniProtKB:P17252 and ensembl:ENSP000004086951600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcaRatdendrite located_inISOPrkca (Mus musculus)1624291 PMID:12115694RGDPMID:12115694
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Molecular Function
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PrkcaRatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
PrkcaRatATP binding enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
PrkcaRatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
PrkcaRatcalcium,diacylglycerol-dependent serine/threonine kinase activity  IDA 731217 RGD 
PrkcaRatcalcium,diacylglycerol-dependent serine/threonine kinase activity enablesISOPrkca (Mus musculus)1624291 PMID:10879655 more ...RGDPMID:10879655 more ...
PrkcaRatcalcium,diacylglycerol-dependent serine/threonine kinase activity enablesISOPRKCA (Homo sapiens)1624291 PMID:25313067 and PMID:33934390RGDPMID:25313067 and PMID:33934390
PrkcaRatcalcium,diacylglycerol-dependent serine/threonine kinase activity enablesIEAUniProtKB:P17252 and ensembl:ENSP000004086951600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcaRatcalcium,diacylglycerol-dependent serine/threonine kinase activity  IDA 5131882 RGD 
PrkcaRatcalcium,diacylglycerol-dependent serine/threonine kinase activity  IDA 5131655 RGD 
PrkcaRatdiacylglycerol-dependent serine/threonine kinase activity enablesISOPRKCA (Homo sapiens)1624291 PMID:12391145 more ...RGDPMID:12391145 more ...
PrkcaRatdiacylglycerol-dependent serine/threonine kinase activity enablesIEAInterPro:IPR0143751600115GO_REF:0000002InterProGO_REF:0000002
PrkcaRatdiacylglycerol-dependent serine/threonine kinase activity enablesIEAInterPro:IPR014375 and InterPro:IPR0346631600115GO_REF:0000002InterProGO_REF:0000002
PrkcaRatdiacylglycerol-dependent serine/threonine kinase activity enablesISOPrkca (Mus musculus)1624291 PMID:12618484 more ...RGDPMID:12618484 more ...
PrkcaRatdiacylglycerol-dependent serine/threonine kinase activity enablesIEAEC:2.7.11.131600115GO_REF:0000003UniProtGO_REF:0000003
PrkcaRatenzyme binding enablesIEAUniProtKB:P17252 and ensembl:ENSP000004086951600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcaRatenzyme binding enablesISOPRKCA (Homo sapiens)1624291UniProtKB:Q9HAW8 and PMID:18556656RGDPMID:18556656
PrkcaRathistone H3T6 kinase activity enablesIEAUniProtKB:P17252 and ensembl:ENSP000004086951600115GO_REF:0000107EnsemblGO_REF:0000107
PrkcaRathistone H3T6 kinase activity enablesISOPRKCA (Homo sapiens)1624291 PMID:20228790RGDPMID:20228790
PrkcaRatintegrin binding enablesISOPrkca (Mus musculus)1624291UniProtKB:O54890 and PMID:16014375RGDPMID:16014375
PrkcaRatkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  

Imported Annotations - SMPDB

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PrkcaRatFc epsilon receptor mediated signaling pathway  ISOPRKCA (Homo sapiens)10402751 SMPDBSMP:00358

Imported Annotations - KEGG (archival)

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Imported Annotations - PID (archival)


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Reference Title
Reference Citation
1. Protein kinase C alpha expression in normal breast, ductal carcinoma in situ and invasive ductal carcinoma. Ainsworth PD, etal., Eur J Cancer. 2004 Oct;40(15):2269-73.
2. Protein kinase C translocation and PKC-dependent protein phosphorylation during myocardial ischemia. Albert CJ and Ford DA, Am J Physiol. 1999 Feb;276(2 Pt 2):H642-50.
3. Invasive human pituitary tumors express a point-mutated alpha-protein kinase-C. Alvaro V, etal., J Clin Endocrinol Metab. 1993 Nov;77(5):1125-9.
4. Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. Ansar S and Edvinsson L, Stroke. 2008 Jan;39(1):185-90. Epub 2007 Nov 21.
5. Protein kinase C isoform expression as a predictor of disease outcome on endocrine therapy in breast cancer. Assender JW, etal., J Clin Pathol. 2007 Nov;60(11):1216-21.
6. Age-associated changes in the expression pattern of cyclooxygenase-2 and related apoptotic markers in the cancer susceptible region of rat prostate. Badawi AF, etal., Carcinogenesis. 2004 Sep;25(9):1681-8. Epub 2004 Apr 29.
7. Alterations in protein kinase C isoenzyme expression and autophosphorylation during the progression of pressure overload-induced left ventricular hypertrophy. Bayer AL, etal., Mol Cell Biochem. 2003 Jan;242(1-2):145-52.
8. Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure. Belin RJ, etal., Circ Res. 2007 Jul 20;101(2):195-204. Epub 2007 Jun 7.
9. Sevoflurane-induced cardioprotection depends on PKC-alpha activation via production of reactive oxygen species. Bouwman RA, etal., Br J Anaesth. 2007 Nov;99(5):639-45. Epub 2007 Sep 27.
10. Increased protein kinase C activity and expression of Ca2+-sensitive isoforms in the failing human heart. Bowling N, etal., Circulation. 1999 Jan 26;99(3):384-91.
11. Regulation of protein kinase C isozymes in volume overload cardiac hypertrophy. Braun MU, etal., Mol Cell Biochem. 2004 Jul;262(1-2):135-43.
12. PKC alpha regulates the hypertrophic growth of cardiomyocytes through extracellular signal-regulated kinase1/2 (ERK1/2). Braz JC, etal., J Cell Biol. 2002 Mar 4;156(5):905-19. Epub 2002 Feb 25.
13. Altered PKC expression and phosphorylation in response to the nature, direction, and magnitude of mechanical stretch. Bullard TA, etal., Can J Physiol Pharmacol. 2007 Feb;85(2):243-50.
14. Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Chen YM, etal., Proc Natl Acad Sci U S A. 2006 May 30;103(22):8534-9. doi: 10.1073/pnas.0509955103. Epub 2006 May 22.
15. Skin immunosenescence: decreased receptor for activated C kinase-1 expression correlates with defective tumour necrosis factor-alpha production in epidermal cells. Corsini E, etal., Br J Dermatol. 2009 Jan;160(1):16-25. Epub 2008 Oct 11.
16. Alcohol-induced protein kinase Calpha phosphorylation of Munc18c in carbachol-stimulated acini causes basolateral exocytosis. Cosen-Binker LI, etal., Gastroenterology. 2007 Apr;132(4):1527-45. Epub 2007 Jan 26.
17. Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat. Crocenzi FA, etal., Hepatology. 2008 Dec;48(6):1885-95.
18. Quantitative trait loci disposing for both experimental arthritis and encephalomyelitis in the DA rat; impact on severity of myelin oligodendrocyte glycoprotein-induced experimental autoimmune encephalomyelitis and antibody isotype pattern. Dahlman I, etal., Eur J Immunol 1998 Jul;28(7):2188-96
19. PICK1 interacts with and regulates PKC phosphorylation of mGLUR7. Dev KK, etal., J Neurosci. 2000 Oct 1;20(19):7252-7.
20. Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. Du J, etal., J Neurosci. 2004 Jul 21;24(29):6578-89.
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PMID:2023931   PMID:3045562   PMID:3666147   PMID:7520444   PMID:7539802   PMID:7741753   PMID:7828597   PMID:7864897   PMID:7929424   PMID:8083223   PMID:8631738   PMID:8947489  
PMID:9447980   PMID:9508782   PMID:9535877   PMID:9830023   PMID:9927633   PMID:10365161   PMID:10407019   PMID:10617144   PMID:10722046   PMID:10770950   PMID:10813773   PMID:10848585  
PMID:10871288   PMID:10879655   PMID:10882525   PMID:11118818   PMID:11123317   PMID:11278415   PMID:11306676   PMID:11738801   PMID:11795668   PMID:11850425   PMID:11906323   PMID:11909826  
PMID:11916978   PMID:11923480   PMID:11940581   PMID:11952172   PMID:11981754   PMID:12079385   PMID:12112001   PMID:12115694   PMID:12198656   PMID:12391145   PMID:12426311   PMID:12477932  
PMID:12525479   PMID:12551925   PMID:12562894   PMID:12612139   PMID:12618484   PMID:12637266   PMID:12637991   PMID:12647293   PMID:12700627   PMID:12700701   PMID:12724315   PMID:12785016  
PMID:12826667   PMID:12928424   PMID:12967633   PMID:12970181   PMID:12970360   PMID:14602083   PMID:14613966   PMID:14638691   PMID:14681019   PMID:14698304   PMID:14717343   PMID:14966518  
PMID:15100355   PMID:15149857   PMID:15157674   PMID:15182202   PMID:15187091   PMID:15262987   PMID:15271671   PMID:15383279   PMID:15388777   PMID:15456937   PMID:15557340   PMID:15574738  
PMID:15590069   PMID:15632189   PMID:15632699   PMID:15748507   PMID:15763930   PMID:15784685   PMID:15830100   PMID:15833739   PMID:15838306   PMID:16014375   PMID:16099831   PMID:16114872  
PMID:16131649   PMID:16155104   PMID:16205321   PMID:16342423   PMID:16407557   PMID:16476439   PMID:16585392   PMID:16630892   PMID:16648180   PMID:16814779   PMID:16870611   PMID:16900949  
PMID:17109817   PMID:17178122   PMID:17208995   PMID:17209006   PMID:17252537   PMID:17267947   PMID:17363267   PMID:17392515   PMID:17487264   PMID:17531159   PMID:17558679   PMID:17591920  
1 to 10 of 22 rows



Prkca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,388,991 - 93,787,617 (-)NCBIGRCr8
mRatBN7.21092,889,390 - 93,288,013 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,894,012 - 93,288,012 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,947,717 - 98,345,380 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,410,758 - 97,808,441 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,819,189 - 93,215,677 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01096,186,509 - 96,585,168 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1096,191,133 - 96,584,947 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,919,013 - 96,311,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,367,196 - 97,638,910 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,382,023 - 97,632,491 (-)NCBI
Celera1091,557,626 - 91,951,823 (-)NCBICelera
RH 3.4 Map101035.79RGD
Cytogenetic Map10q32.1NCBI
PRKCA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381766,302,613 - 66,810,743 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1766,302,613 - 66,810,743 (+)EnsemblGRCh38hg38GRCh38
GRCh371764,298,731 - 64,806,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361761,729,388 - 62,237,324 (+)NCBINCBI36Build 36hg18NCBI36
Build 341761,729,387 - 62,237,324NCBI
Celera1760,870,958 - 61,379,534 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1759,689,927 - 60,196,110 (+)NCBIHuRef
CHM1_11764,362,982 - 64,870,449 (+)NCBICHM1_1
T2T-CHM13v2.01767,172,339 - 67,686,559 (+)NCBIT2T-CHM13v2.0
Prkca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911107,824,213 - 108,237,360 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11107,824,213 - 108,234,754 (-)EnsemblGRCm39 Ensembl
GRCm3811107,933,387 - 108,343,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11107,933,387 - 108,343,928 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711107,794,701 - 108,205,202 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611107,754,338 - 108,160,018 (-)NCBIMGSCv36mm8
Celera11119,670,475 - 120,082,817 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.8NCBI
Prkca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554785,686,640 - 6,083,967 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554785,686,639 - 6,090,356 (+)NCBIChiLan1.0ChiLan1.0
PRKCA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21982,339,665 - 82,840,386 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11787,159,077 - 87,659,700 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01760,246,485 - 60,747,158 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11765,454,911 - 65,954,610 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1765,454,907 - 65,947,903 (+)Ensemblpanpan1.1panPan2
PRKCA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1913,638,106 - 13,879,571 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl913,644,010 - 13,967,630 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha914,532,025 - 14,927,673 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0915,300,837 - 15,695,928 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl915,305,948 - 15,696,186 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1914,247,910 - 14,642,594 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0912,891,369 - 13,286,136 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0912,891,959 - 13,287,663 (+)NCBIUU_Cfam_GSD_1.0
Prkca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560212,615,841 - 12,962,986 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365416,233,110 - 6,488,052 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365416,231,604 - 6,488,201 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKCA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1212,882,064 - 13,263,554 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11212,882,287 - 13,268,647 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21213,197,691 - 13,602,529 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PRKCA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11654,638,548 - 55,144,372 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1654,642,729 - 54,948,256 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607725,683,064 - 26,190,115 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prkca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248701,596,102 - 2,023,172 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248701,589,775 - 2,023,160 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Prkca
3031 total Variants

Predicted Target Of
Summary Value
Count of predictions:822
Count of miRNA genes:230
Interacting mature miRNAs:255
Transcripts:ENSRNOT00000004699, ENSRNOT00000055073
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 79 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105057470795574707Rat
1354641Bvd2Brain ventricular dilatation QTL 26.360.001brain ventricle morphology trait (VT:0000822)hydrocephalus severity score (CMO:0001881)1093223816107057807Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
61449Ciaa2CIA Autoantibody QTL 27.1blood autoantibody amount (VT:0003725)calculated serum anti-type 2 collagen antibody titer (CMO:0001279)1063221094107211142Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042045676104670812Rat
1549831Bss6Bone structure and strength QTL 64lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)1057576521102576521Rat
1579915Bp280Blood pressure QTL 2800.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1090404397107211142Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105379749498952626Rat
2298548Neuinf7Neuroinflammation QTL 73.4nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)1072224939107211142Rat

1 to 10 of 79 rows
D10Rat53  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21093,184,764 - 93,184,904 (+)MAPPERmRatBN7.2
Rnor_6.01096,482,302 - 96,482,441NCBIRnor6.0
Rnor_5.01096,209,202 - 96,209,341UniSTSRnor5.0
Celera1091,849,622 - 91,849,761UniSTS
RH 3.4 Map101036.2RGD
RH 3.4 Map101036.2UniSTS
RH 2.0 Map101145.8RGD
FHH x ACI Map1076.87RGD
Cytogenetic Map10q32.1UniSTS
D10Rat189  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81093,723,381 - 93,723,576 (+)Marker Load Pipeline
mRatBN7.21093,223,816 - 93,224,011 (+)MAPPERmRatBN7.2
Rnor_6.01096,520,816 - 96,521,010NCBIRnor6.0
Rnor_5.01096,247,437 - 96,247,631UniSTSRnor5.0
Celera1091,888,082 - 91,888,276UniSTS
RH 2.0 Map101138.3RGD
FHH x ACI Map1076.87RGD
Cytogenetic Map10q32.1UniSTS
D10Rat139  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1091,706,718 - 91,707,295UniSTS
RH 2.0 Map101130.4RGD
SHRSP x BN Map1073.35RGD
Cytogenetic Map10q32.1UniSTS
D10Chm19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,997,482 - 92,997,642 (+)MAPPERmRatBN7.2
Rnor_6.01096,295,049 - 96,295,208NCBIRnor6.0
Rnor_5.01096,022,399 - 96,022,558UniSTSRnor5.0
RGSC_v3.41097,470,298 - 97,470,457UniSTSRGSC3.4
Celera1091,660,804 - 91,660,963UniSTS
Cytogenetic Map10q32.1UniSTS
D10Chm12  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81093,481,120 - 93,481,325 (+)Marker Load Pipeline
mRatBN7.21092,981,530 - 92,981,737 (+)MAPPERmRatBN7.2
Rnor_6.01096,279,083 - 96,279,287NCBIRnor6.0
Rnor_5.01096,006,498 - 96,006,702UniSTSRnor5.0
RGSC_v3.41097,454,479 - 97,454,683UniSTSRGSC3.4
Celera1091,644,856 - 91,645,060UniSTS
Cytogenetic Map10q32.1UniSTS
RH94851  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81093,394,110 - 93,394,350 (+)Marker Load Pipeline
mRatBN7.21092,894,507 - 92,894,747 (+)MAPPERmRatBN7.2
Rnor_6.01096,191,629 - 96,191,868NCBIRnor6.0
Rnor_5.01095,919,509 - 95,919,748UniSTSRnor5.0
RGSC_v3.41097,367,692 - 97,367,931UniSTSRGSC3.4
Celera1091,558,122 - 91,558,361UniSTS
RH 3.4 Map101035.79UniSTS
Cytogenetic Map10q32.1UniSTS
Prkca  
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.41097,368,649 - 97,368,778UniSTSRGSC3.4
RGSC_v3.41097,368,649 - 97,368,881UniSTSRGSC3.4
Celera1091,559,079 - 91,559,208UniSTS
Celera1091,559,079 - 91,559,311UniSTS
RH94850  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21092,894,869 - 92,895,073 (+)MAPPERmRatBN7.2
Rnor_6.01096,191,991 - 96,192,194NCBIRnor6.0
Rnor_5.01095,919,871 - 95,920,074UniSTSRnor5.0
RGSC_v3.41097,368,054 - 97,368,257UniSTSRGSC3.4
Celera1091,558,484 - 91,558,687UniSTS
Cytogenetic Map10q32.1UniSTS
RH137792  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21093,238,639 - 93,238,779 (+)MAPPERmRatBN7.2
Rnor_6.01096,535,775 - 96,535,914NCBIRnor6.0
Rnor_5.01096,261,992 - 96,262,131UniSTSRnor5.0
Celera1091,902,756 - 91,902,895UniSTS
Cytogenetic Map10q32.1UniSTS
fk85g05.x1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01657,183,630 - 57,183,785UniSTSRnor5.0
Rnor_5.01096,021,469 - 96,022,449UniSTSRnor5.0
RGSC_v3.41657,645,822 - 57,645,977UniSTSRGSC3.4
RGSC_v3.41097,469,368 - 97,470,348UniSTSRGSC3.4
Celera1651,895,620 - 51,895,775UniSTS
Celera1091,659,874 - 91,660,854UniSTS
Cytogenetic Map16q12.1UniSTS
Cytogenetic Map10q32.1UniSTS
Prkca  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01095,920,466 - 95,920,698UniSTSRnor5.0
RGSC_v3.41097,368,649 - 97,368,881UniSTSRGSC3.4
Celera1091,559,079 - 91,559,311UniSTS
Cytogenetic Map10q32.1UniSTS
Prkca  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.01095,920,466 - 95,920,595UniSTSRnor5.0
RGSC_v3.41097,368,649 - 97,368,778UniSTSRGSC3.4
Celera1091,559,079 - 91,559,208UniSTS
Cytogenetic Map10q32.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000004699   ⟹   ENSRNOP00000004699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,894,264 - 93,287,756 (-)Ensembl
Rnor_6.0 Ensembl1096,191,385 - 96,584,896 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000055073   ⟹   ENSRNOP00000051949
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,894,012 - 93,287,807 (-)Ensembl
Rnor_6.0 Ensembl1096,191,133 - 96,584,947 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000100596   ⟹   ENSRNOP00000079110
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,895,139 - 93,287,807 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112512   ⟹   ENSRNOP00000083509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,894,264 - 93,135,944 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115522   ⟹   ENSRNOP00000091320
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1092,894,264 - 93,288,012 (-)Ensembl
RefSeq Acc Id: NM_001399299   ⟹   NP_001386228
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81093,388,991 - 93,787,327 (-)NCBI
mRatBN7.21092,889,390 - 93,287,767 (-)NCBI
RefSeq Acc Id: XM_017597006   ⟹   XP_017452495
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81093,388,991 - 93,787,617 (-)NCBI
mRatBN7.21092,889,390 - 93,287,801 (-)NCBI
Rnor_6.01096,186,509 - 96,585,168 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039085211   ⟹   XP_038941139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81093,388,991 - 93,787,617 (-)NCBI
mRatBN7.21092,889,390 - 93,288,013 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_001386228 (Get FASTA)   NCBI Sequence Viewer  
  NP_001416901 (Get FASTA)   NCBI Sequence Viewer  
  XP_017452495 (Get FASTA)   NCBI Sequence Viewer  
  XP_038941139 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI69007 (Get FASTA)   NCBI Sequence Viewer  
  EDM06446 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004699
  ENSRNOP00000004699.8
  ENSRNOP00000079110
GenBank Protein P05696 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: XP_017452495   ⟸   XM_017597006
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000051949   ⟸   ENSRNOT00000055073
Ensembl Acc Id: ENSRNOP00000004699   ⟸   ENSRNOT00000004699
RefSeq Acc Id: XP_038941139   ⟸   XM_039085211
- Peptide Label: isoform X1
- UniProtKB: F1LS98 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091320   ⟸   ENSRNOT00000115522
AGC-kinase C-terminal   C2   Phorbol-ester/DAG-type   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-P05696-F1-model_v2 AlphaFold P05696 1-672 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697861
Promoter ID:EPDNEW_R8378
Type:initiation region
Name:Prkca_1
Description:protein kinase C, alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01096,584,907 - 96,584,967EPDNEW


1 to 40 of 56 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-22880 BioCyc
Ensembl Genes ENSRNOG00000003491 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004699 ENTREZGENE
  ENSRNOT00000004699.9 UniProtKB/Swiss-Prot
  ENSRNOT00000100596 ENTREZGENE
Gene3D-CATH 2.60.40.150 UniProtKB/Swiss-Prot
  3.30.60.20 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro AGC-kinase_C UniProtKB/Swiss-Prot
  C1-like_sf UniProtKB/Swiss-Prot
  C2_dom UniProtKB/Swiss-Prot
  C2_domain_sf UniProtKB/Swiss-Prot
  cPKC_alpha UniProtKB/Swiss-Prot
  DAG/PE-bd UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Protein_kinase_C_a/b/g UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
NCBI Gene 24680 ENTREZGENE
PANTHER RIBOSOMAL PROTEIN S6 KINASE UniProtKB/Swiss-Prot
Pfam C1_1 UniProtKB/Swiss-Prot
  PF00168 UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
  Pkinase_C UniProtKB/Swiss-Prot
PharmGKB PRKCA RGD
PhenoGen Prkca PhenoGen
PIRSF PKC_alpha UniProtKB/Swiss-Prot
PRINTS C2DOMAIN UniProtKB/Swiss-Prot
  DAGPEDOMAIN UniProtKB/Swiss-Prot
PROSITE AGC_KINASE_CTER UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
  PS50004 UniProtKB/Swiss-Prot
  ZF_DAG_PE_1 UniProtKB/Swiss-Prot
  ZF_DAG_PE_2 UniProtKB/Swiss-Prot
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Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Prkca  Protein kinase C, alpha      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in adult ventricular myocytes 731217
gene_pathway activation by the digitalis drug ouabain is linked to Na+/K+-ATPase through Src/EGFR, and is required for the activation of ERK1/2 628493
gene_regulation administration of the digitalis drug ouabain with intact cardiac myocytes causes rapid translocation/activation from the soluble to the particulate pools of enzymes 628493