Pklr (pyruvate kinase L/R) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Pklr (pyruvate kinase L/R) Rattus norvegicus
Analyze
Symbol: Pklr
Name: pyruvate kinase L/R
RGD ID: 3336
Description: Enables monosaccharide binding activity and pyruvate kinase activity. Involved in several processes, including cellular response to epinephrine stimulus; pyruvate metabolic process; and response to purine-containing compound. Predicted to be located in plasma membrane. Predicted to be part of pyruvate kinase complex. Predicted to be active in cytosol. Biomarker of hyperglycemia and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R); PARTICIPATES IN glycolysis pathway; pyruvate metabolic pathway; Fanconi syndrome pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: L-PK; PK1; PKL; Pklg; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase PKLR; pyruvate kinase, liver and RBC; pyruvate kinase, liver and red blood cell
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc   WKY.SHRSP-(Fst-Pklr)/Gcrc  
QTLs:   Niddm8  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,840,779 - 176,849,637 (+)NCBIGRCr8
mRatBN7.22174,543,008 - 174,551,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,543,039 - 174,551,870 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,689,431 - 181,697,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,711,798 - 179,720,184 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,311,737 - 174,320,129 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,449,158 - 188,458,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,449,210 - 188,459,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,865,529 - 207,874,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,214,853 - 181,223,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,164,961 - 181,173,618 (+)NCBI
Celera2168,486,468 - 168,494,841 (+)NCBICelera
RH 3.4 Map21154.4RGD
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
3-phenylprop-2-enal  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aluminium atom  (ISO)
aluminium(0)  (ISO)
amiodarone  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
aristolochic acid A  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (EXP)
atrazine  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
bicalutamide  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bosentan  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium dichloride  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
chlorothalonil  (ISO)
cholesterol  (ISO)
choline  (ISO)
clofibrate  (EXP,ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
D-glucose  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
diethyl maleate  (EXP)
dihydroxyacetone  (EXP)
Diosbulbin B  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
duvoglustat  (ISO)
endosulfan  (EXP,ISO)
epoxiconazole  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
fenofibrate  (ISO)
fenthion  (ISO)
flavonoids  (EXP)
flutamide  (EXP,ISO)
fructose  (EXP,ISO)
furan  (EXP)
gentamycin  (EXP)
glucose  (EXP,ISO)
glyburide  (EXP)
glycerol  (EXP,ISO)
hexadecanoic acid  (ISO)
hydroxyurea  (ISO)
indometacin  (EXP)
isotretinoin  (ISO)
L-ethionine  (EXP)
L-methionine  (ISO)
Lasiocarpine  (ISO)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naloxone  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nicotine  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
nordihydroguaiaretic acid  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
octadecanoic acid  (ISO)
oleic acid  (ISO)
omeprazole  (EXP)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-anisidine  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
PCB138  (EXP)
penconazole  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylephrine  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
procymidone  (ISO)
propamocarb  (ISO)
propane-1,2-diol  (ISO)
propiconazole  (EXP)
Propiverine  (EXP)
prostaglandin E2  (ISO)
quinidine  (EXP)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
streptozocin  (EXP,ISO)
succimer  (ISO)
sucrose  (ISO)
sulforaphane  (EXP)
sulprostone  (ISO)
suxibuzone  (EXP)
tamoxifen  (EXP,ISO)
taurine  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thapsigargin  (EXP)
theophylline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triadimefon  (EXP)
trichloroethene  (EXP)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP,ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP)
valdecoxib  (EXP)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits. Andreasen CH, etal., BMC Med Genet. 2008 Dec 26;9:118. doi: 10.1186/1471-2350-9-118.
2. Tungstate is an effective antidiabetic agent in streptozotocin-induced diabetic rats: a long-term study. Barbera A, etal., Diabetologia. 2001 Apr;44(4):507-13.
3. Differential hepatic gene expression in a polygenic mouse model with insulin resistance and hyperglycemia: evidence for a combined transcriptional dysregulation of gluconeogenesis and fatty acid synthesis. Becker W, etal., J Mol Endocrinol. 2004 Feb;32(1):195-208.
4. Rat liver pyruvate kinase: influence of ligands on activity and fructose 1,6-bisphosphate binding. Blair JB and Walker RG, Arch Biochem Biophys. 1984 Jul;232(1):202-13. doi: 10.1016/0003-9861(84)90536-8.
5. Key enzymes of carbohydrate metabolism as targets of the 11.5-kDa Zn(2+)-binding protein (parathymosin). Brand IA and Heinickel A, J Biol Chem. 1991 Nov 5;266(31):20984-9.
6. Red blood cell PK deficiency: An update of PK-LR gene mutation database. Canu G, etal., Blood Cells Mol Dis. 2016 Mar;57:100-9. doi: 10.1016/j.bcmd.2015.12.009. Epub 2016 Jan 12.
7. Structure of the rat L-type pyruvate kinase gene. Cognet M, etal., J Mol Biol 1987 Jul 5;196(1):11-25.
8. Insulin and cyclic AMP act at different levels on transcription of the L-type pyruvate kinase gene. Cuif MH, etal., FEBS Lett. 1997 Nov 3;417(1):81-4.
9. Pyruvate kinase activation and lipoperoxidation after selective hepatic ischemia in Wistar rats. de Faatima Santana Ferreira Boin I, etal., Acta Cir Bras. 2006;21 Suppl 1:19-23.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Relationships between concentration of hepatic intermediary metabolites and induction of the key glycolytic enzymes in vivo. Gunn JM and Taylor CB, Biochem J. 1973 Nov;136(3):455-65.
12. Disordered expression of hepatic glycolytic and gluconeogenic enzymes in Otsuka Long-Evans Tokushima fatty rats with spontanteous long-term hyperglycemia. Hotta K, etal., Biochim Biophys Acta. 1996 Feb 9;1289(1):145-9.
13. Dietary lipoic acid-dependent changes in the activity and mRNA levels of hepatic lipogenic enzymes in rats. Huong DT and Ide T, Br J Nutr. 2008 Jul;100(1):79-87. Epub 2007 Dec 7.
14. Exogenous Mg-ATP induces a large inhibition of pyruvate kinase in intact rat hepatocytes. Ichai C, etal., J Biol Chem. 2001 Mar 2;276(9):6398-403. Epub 2000 Dec 4.
15. Complete amino acid sequence of rat L-type pyruvate kinase deduced from the cDNA sequence. Inoue H, etal., Eur J Biochem 1986 Jan 15;154(2):465-9.
16. Some kinetic properties of liver pyruvate kinase (type L). 3. Effect of monovalent cations on its allosteric behavior. Jimenez de Asua L, etal., J Biol Chem. 1970 Aug 10;245(15):3901-5.
17. Identical point mutations of the R-type pyruvate kinase (PK) cDNA found in unrelated PK variants associated with hereditary hemolytic anemia. Kanno H, etal., Blood. 1992 Mar 1;79(5):1347-50.
18. Molecular abnormality of erythrocyte pyruvate kinase deficiency in the Amish. Kanno H, etal., Blood. 1994 Apr 15;83(8):2311-6.
19. Hereditary hemolytic anemia caused by diverse point mutations of pyruvate kinase gene found in Japan and Hong Kong. Kanno H, etal., Blood. 1994 Nov 15;84(10):3505-9.
20. Primary structure of murine red blood cell-type pyruvate kinase (PK) and molecular characterization of PK deficiency identified in the CBA strain. Kanno H, etal., Blood. 1995 Oct 15;86(8):3205-10.
21. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
22. Fuel and hormone regulation of phospholipase C beta 1 and delta 1 overexpressed in RINm5F pancreatic beta cells. Kelley GG, etal., Mol Cell Endocrinol. 2001 May 25;177(1-2):107-15.
23. Cross-talk between the signals hypoxia and glucose at the glucose response element of the L-type pyruvate kinase gene. Krones A, etal., Endocrinology 2001 Jun;142(6):2707-18.
24. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
25. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
26. Complete nucleotide and deduced amino acid sequences of rat L-type pyruvate kinase. Lone YC, etal., FEBS Lett 1986 Jan 20;195(1-2):97-100.
27. Sequences complementary to the brain-specific "identifier" sequences exist in L-type pyruvate kinase mRNA (a liver-specific messenger) and in transcripts especially abundant in muscle. Lone YC, etal., J Biol Chem 1986 Feb 5;261(4):1499-502.
28. Malaria: looking for selection signatures in the human PKLR gene region. Machado P, etal., Br J Haematol. 2010 Jun;149(5):775-84. doi: 10.1111/j.1365-2141.2010.08165.x. Epub 2010 Apr 4.
29. A new PKLR gene mutation in the R-type promoter region affects the gene transcription causing pyruvate kinase deficiency. Manco L, etal., Br J Haematol. 2000 Sep;110(4):993-7.
30. Tissue-specific heterogeneity of the 3'-untranslated region of L-type pyruvate kinase mRNAs. Marie J, etal., Eur J Biochem 1986 Jul 1;158(1):33-41.
31. Rescue of pyruvate kinase deficiency in mice by gene therapy using the human isoenzyme. Meza NW, etal., Mol Ther. 2009 Dec;17(12):2000-9. doi: 10.1038/mt.2009.200. Epub 2009 Sep 15.
32. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
33. Pyruvate kinase deficiency in mice protects against malaria. Min-Oo G, etal., Nat Genet. 2003 Dec;35(4):357-62. Epub 2003 Nov 2.
34. In vivo effect of Trigonella foenum graecum on the expression of pyruvate kinase, phosphoenolpyruvate carboxykinase, and distribution of glucose transporter (GLUT4) in alloxan-diabetic rats. Mohammad S, etal., Can J Physiol Pharmacol. 2006 Jun;84(6):647-54.
35. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
36. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
37. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
38. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
39. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
40. Pyruvate kinase deficiency in France: a 3-year study reveals 27 new mutations. Pissard S, etal., Br J Haematol. 2006 Jun;133(6):683-9.
41. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
42. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
43. Overexpression of c-myc in the liver prevents obesity and insulin resistance. Riu E, etal., FASEB J. 2003 Sep;17(12):1715-7. Epub 2003 Jul 18.
44. Linkage disequilibrium of common Gaucher disease mutations with a polymorphic site in the pyruvate kinase (PKLR) gene. Rockah R, etal., Am J Med Genet. 1998 Jul 7;78(3):233-6.
45. Lithium's effects on rat liver glucose metabolism in vivo. Rodriguez-Gil JE, etal., Arch Biochem Biophys. 2000 Mar 15;375(2):377-84.
46. Molecular cloning and nucleotide sequence of the gene for pyruvate kinase of Bacillus stearothermophilus and the production of the enzyme in Escherichia coli. Evidence that the genes for phosphofructokinase and pyruvate kinase constitute an operon. Sakai H and Ohta T, Eur J Biochem 1993 Feb 1;211(3):851-9.
47. Modulation of gluconeogenesis by epinephrine in hepatocytes isolated from genetically obese (fa/fa) Zucker rats. Sanchez-Gutierrez JC, etal., Arch Biochem Biophys. 2000 Jan 1;373(1):249-54.
48. Effect of sesame seeds rich in sesamin and sesamolin on fatty acid oxidation in rat liver. Sirato-Yasumoto S, etal., J Agric Food Chem. 2001 May;49(5):2647-51.
49. Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in northern European Caucasians. Wang H, etal., Diabetes. 2002 Sep;51(9):2861-5.
50. Induction and suppression of the key enzymes of glycolysis and gluconeogenesis in isolated perfused rat liver in response to glucose, fructose and lactate. Wimhurst JM and Manchester KL, Biochem J. 1973 May;134(1):143-56.
51. Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. Xu J, etal., J Biol Chem. 2006 Jul 7;281(27):18351-62. Epub 2006 Apr 27.
52. Effect of Creosote Bush-Derived NDGA on Expression of Genes Involved in Lipid Metabolism in Liver of High-Fructose Fed Rats: Relevance to NDGA Amelioration of Hypertriglyceridemia and Hepatic Steatosis. Zhang H, etal., PLoS One. 2015 Sep 22;10(9):e0138203. doi: 10.1371/journal.pone.0138203. eCollection 2015.
53. Effect of thermal injury on relative anaplerosis and gluconeogenesis in the rat during infusion of [U-13C] propionate. Zhaofan X, etal., Burns. 2002 Nov;28(7):625-30.
Additional References at PubMed
PMID:3654663   PMID:7295297   PMID:11960989   PMID:12477932   PMID:12480946   PMID:15155459   PMID:15196592   PMID:15996096   PMID:16170200   PMID:16204235   PMID:17160355   PMID:17341548  
PMID:18468514   PMID:18698006   PMID:19056867   PMID:19406844   PMID:19631660   PMID:21239437   PMID:22878931   PMID:31825824   PMID:36755387  


Genomics

Comparative Map Data
Pklr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82176,840,779 - 176,849,637 (+)NCBIGRCr8
mRatBN7.22174,543,008 - 174,551,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2174,543,039 - 174,551,870 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2181,689,431 - 181,697,810 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02179,711,798 - 179,720,184 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02174,311,737 - 174,320,129 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02188,449,158 - 188,458,034 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2188,449,210 - 188,459,592 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02207,865,529 - 207,874,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42181,214,853 - 181,223,505 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12181,164,961 - 181,173,618 (+)NCBI
Celera2168,486,468 - 168,494,841 (+)NCBICelera
RH 3.4 Map21154.4RGD
Cytogenetic Map2q34NCBI
PKLR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381155,289,293 - 155,308,654 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1155,289,293 - 155,301,438 (-)EnsemblGRCh38hg38GRCh38
GRCh371155,259,084 - 155,271,229 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361153,526,254 - 153,537,835 (-)NCBINCBI36Build 36hg18NCBI36
Build 341152,072,702 - 152,084,298NCBI
Celera1128,332,260 - 128,344,368 (-)NCBICelera
Cytogenetic Map1q22NCBI
HuRef1126,621,396 - 126,633,527 (-)NCBIHuRef
CHM1_11156,654,499 - 156,666,666 (-)NCBICHM1_1
T2T-CHM13v2.01154,427,854 - 154,447,170 (-)NCBIT2T-CHM13v2.0
Pklr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39389,043,429 - 89,054,122 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl389,043,449 - 89,054,091 (+)EnsemblGRCm39 Ensembl
GRCm38389,136,122 - 89,146,815 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl389,136,142 - 89,146,784 (+)EnsemblGRCm38mm10GRCm38
MGSCv37388,940,064 - 88,950,516 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36389,222,069 - 89,231,560 (+)NCBIMGSCv36mm8
Celera389,168,271 - 89,180,284 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
Pklr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555451,739,152 - 1,749,632 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555451,742,432 - 1,749,632 (-)NCBIChiLan1.0ChiLan1.0
PKLR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2194,540,674 - 94,554,495 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1194,272,005 - 94,285,754 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01130,634,111 - 130,646,644 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11134,239,565 - 134,250,957 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1134,239,565 - 134,251,351 (-)Ensemblpanpan1.1panPan2
PKLR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1742,263,899 - 42,272,770 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl742,263,761 - 42,272,755 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha741,754,768 - 41,762,716 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0742,132,983 - 42,141,903 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl742,133,018 - 42,141,000 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1741,912,888 - 41,920,846 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,966,693 - 41,974,641 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0742,250,696 - 42,258,642 (+)NCBIUU_Cfam_GSD_1.0
Pklr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505825,740,581 - 25,749,528 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365804,767,109 - 4,779,916 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365804,770,977 - 4,799,316 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKLR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl494,537,019 - 94,546,555 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1494,536,978 - 94,546,561 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24103,324,615 - 103,327,436 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PKLR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1208,540,228 - 8,547,184 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl208,540,763 - 8,545,884 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660387,877,122 - 7,888,169 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pklr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248852,264,928 - 2,272,171 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248852,261,850 - 2,272,175 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pklr
22 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:481
Count of miRNA genes:183
Interacting mature miRNAs:217
Transcripts:ENSRNOT00000027700, ENSRNOT00000065791
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat
61457Niddm8Non-insulin dependent diabetes mellitus QTL 84.10.01blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)2174543008175950118Rat

Markers in Region
D2Mit20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.245,401,881 - 5,402,004 (-)MAPPERmRatBN7.2
Rnor_6.042,864,180 - 2,864,302NCBIRnor6.0
Rnor_5.042,914,519 - 2,914,621NCBIRnor5.0
RGSC_v3.44638,592 - 638,715RGDRGSC3.4
RGSC_v3.44638,593 - 638,715UniSTSRGSC3.4
RGSC_v3.14638,593 - 638,715RGD
Celera44,914,519 - 4,914,641UniSTS
RH 3.4 Map21154.4RGD
RH 3.4 Map21154.4UniSTS
RH 2.0 Map2881.7RGD
FHH x ACI Map276.6299RGD
Cytogenetic Map2q34UniSTS
D2Wox19  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,540,761 - 174,540,907 (+)MAPPERmRatBN7.2
Rnor_6.02188,446,935 - 188,447,078NCBIRnor6.0
Rnor_5.02207,863,301 - 207,863,444UniSTSRnor5.0
RGSC_v3.42181,212,126 - 181,212,270RGDRGSC3.4
RGSC_v3.42181,212,127 - 181,212,270UniSTSRGSC3.4
RGSC_v3.12181,162,232 - 181,162,376RGD
Celera2168,483,756 - 168,483,887UniSTS
Cytogenetic Map2q34UniSTS
D2Wox20  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,541,858 - 174,542,034 (+)MAPPERmRatBN7.2
Rnor_6.02188,448,030 - 188,448,205NCBIRnor6.0
Rnor_5.02207,864,396 - 207,864,571UniSTSRnor5.0
RGSC_v3.42181,213,221 - 181,213,397RGDRGSC3.4
RGSC_v3.42181,213,222 - 181,213,397UniSTSRGSC3.4
RGSC_v3.12181,163,327 - 181,163,503RGD
Celera2168,484,839 - 168,485,012UniSTS
Cytogenetic Map2q34UniSTS
D2Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,540,754 - 174,540,927 (+)MAPPERmRatBN7.2
Rnor_6.02188,446,928 - 188,447,098NCBIRnor6.0
Rnor_5.02207,863,294 - 207,863,464UniSTSRnor5.0
RGSC_v3.42181,212,119 - 181,212,290RGDRGSC3.4
RGSC_v3.42181,212,120 - 181,212,290UniSTSRGSC3.4
RGSC_v3.12181,162,225 - 181,162,396RGD
Celera2168,483,749 - 168,483,907UniSTS
RH 3.4 Map21157.4UniSTS
RH 3.4 Map21157.4RGD
Cytogenetic Map2q34UniSTS
D2Wox22  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,541,843 - 174,541,995 (+)MAPPERmRatBN7.2
Rnor_6.02188,448,015 - 188,448,166NCBIRnor6.0
Rnor_5.02207,864,381 - 207,864,532UniSTSRnor5.0
RGSC_v3.42181,213,206 - 181,213,358RGDRGSC3.4
RGSC_v3.42181,213,207 - 181,213,358UniSTSRGSC3.4
RGSC_v3.12181,163,312 - 181,163,464RGD
Celera2168,484,824 - 168,484,973UniSTS
Cytogenetic Map2q34UniSTS
D2Arb15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,546,281 - 174,546,480 (+)MAPPERmRatBN7.2
Rnor_6.02188,452,453 - 188,452,651NCBIRnor6.0
Rnor_5.02207,868,819 - 207,869,017UniSTSRnor5.0
RGSC_v3.42181,217,645 - 181,217,844RGDRGSC3.4
RGSC_v3.42181,217,646 - 181,217,844UniSTSRGSC3.4
RGSC_v3.12181,167,751 - 181,167,950RGD
Celera2168,489,260 - 168,489,458UniSTS
SHRSP x BN Map271.2798UniSTS
SHRSP x BN Map271.2798RGD
FHH x ACI Map276.5599RGD
Cytogenetic Map2q34UniSTS
D2Mgh28  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,546,354 - 174,546,494 (+)MAPPERmRatBN7.2
Rnor_6.02188,452,526 - 188,452,665NCBIRnor6.0
Rnor_5.02207,868,892 - 207,869,031UniSTSRnor5.0
RGSC_v3.42181,217,719 - 181,217,858UniSTSRGSC3.4
RGSC_v3.42181,217,718 - 181,217,858RGDRGSC3.4
RGSC_v3.12181,167,824 - 181,167,964RGD
Celera2168,489,333 - 168,489,472UniSTS
RH 3.4 Map21162.7RGD
RH 3.4 Map21162.7UniSTS
RH 2.0 Map2888.4RGD
SHRSP x BN Map271.5798RGD
FHH x ACI Map276.5599RGD
Cytogenetic Map2q34UniSTS
RH130560  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,551,638 - 174,551,835 (+)MAPPERmRatBN7.2
Rnor_6.02188,457,810 - 188,458,006NCBIRnor6.0
Rnor_5.02207,874,169 - 207,874,365UniSTSRnor5.0
RGSC_v3.42181,223,281 - 181,223,477UniSTSRGSC3.4
Celera2168,494,617 - 168,494,813UniSTS
RH 3.4 Map21156.4UniSTS
Cytogenetic Map2q34UniSTS
RH134398  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,551,207 - 174,551,395 (+)MAPPERmRatBN7.2
Rnor_6.02188,457,379 - 188,457,566NCBIRnor6.0
Rnor_5.02207,873,738 - 207,873,925UniSTSRnor5.0
RGSC_v3.42181,222,850 - 181,223,037UniSTSRGSC3.4
Celera2168,494,186 - 168,494,373UniSTS
RH 3.4 Map21155.2UniSTS
Cytogenetic Map2q34UniSTS
BE105864  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,552,112 - 174,552,267 (+)MAPPERmRatBN7.2
Rnor_6.02188,458,284 - 188,458,438NCBIRnor6.0
Rnor_5.02207,874,643 - 207,874,797UniSTSRnor5.0
RGSC_v3.42181,223,755 - 181,223,909UniSTSRGSC3.4
Celera2168,495,091 - 168,495,245UniSTS
RH 3.4 Map21156.8UniSTS
Cytogenetic Map2q34UniSTS
RH94486  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22174,550,715 - 174,550,884 (+)MAPPERmRatBN7.2
Rnor_6.02188,456,887 - 188,457,055NCBIRnor6.0
Rnor_5.02207,873,246 - 207,873,414UniSTSRnor5.0
RGSC_v3.42181,222,358 - 181,222,526UniSTSRGSC3.4
Celera2168,493,694 - 168,493,862UniSTS
RH 3.4 Map21154.4UniSTS
Cytogenetic Map2q34UniSTS


Related Rat Strains
The following Strains have been annotated to Pklr
WKY.SHRSP-(D2Mit5-D2Mgh12)/Gcrc     WKY.SHRSP-(Fst-Pklr)/Gcrc     WKY/Gla.SHRSP/Gla-(D2Mit5-D2Mgh12)/Gla     WKY/Gla.SHRSP/Gla-(Fst-Pklr)/Gla    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 8 41 41 41 15 2
Low 1 12 11 27 20 21 1
Below cutoff 8 6 1 2 2 40 13 3 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027700   ⟹   ENSRNOP00000027700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,543,039 - 174,551,870 (+)Ensembl
Rnor_6.0 Ensembl2188,449,210 - 188,456,759 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000065791   ⟹   ENSRNOP00000058886
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,543,535 - 174,551,870 (+)Ensembl
Rnor_6.0 Ensembl2188,449,718 - 188,459,592 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000103387   ⟹   ENSRNOP00000093132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2174,543,490 - 174,551,870 (+)Ensembl
RefSeq Acc Id: NM_012624   ⟹   NP_036756
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,841,264 - 176,849,637 (+)NCBI
mRatBN7.22174,543,490 - 174,551,863 (+)NCBI
Rnor_6.02188,449,661 - 188,458,034 (+)NCBI
Rnor_5.02207,865,529 - 207,874,394 (+)NCBI
RGSC_v3.42181,214,853 - 181,223,505 (+)RGD
Celera2168,486,468 - 168,494,841 (+)RGD
Sequence:
RefSeq Acc Id: XM_006232593   ⟹   XP_006232655
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,840,779 - 176,849,637 (+)NCBI
mRatBN7.22174,543,008 - 174,550,926 (+)NCBI
Rnor_6.02188,449,158 - 188,457,097 (+)NCBI
Rnor_5.02207,865,529 - 207,874,394 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039101740   ⟹   XP_038957668
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,841,182 - 176,849,637 (+)NCBI
mRatBN7.22174,543,408 - 174,550,926 (+)NCBI
RefSeq Acc Id: XM_063281304   ⟹   XP_063137374
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,840,779 - 176,845,540 (+)NCBI
RefSeq Acc Id: XM_063281305   ⟹   XP_063137375
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,840,779 - 176,845,552 (+)NCBI
RefSeq Acc Id: XR_005500240
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82176,840,779 - 176,845,901 (+)NCBI
mRatBN7.22174,543,008 - 174,548,123 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036756   ⟸   NM_012624
- UniProtKB: B1WBN9 (UniProtKB/TrEMBL),   A0A0H2UI07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232655   ⟸   XM_006232593
- Peptide Label: isoform X1
- UniProtKB: P04763 (UniProtKB/Swiss-Prot),   Q64618 (UniProtKB/Swiss-Prot),   P12928 (UniProtKB/Swiss-Prot),   A6J6C1 (UniProtKB/TrEMBL),   A0A0H2UI07 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000058886   ⟸   ENSRNOT00000065791
RefSeq Acc Id: ENSRNOP00000027700   ⟸   ENSRNOT00000027700
RefSeq Acc Id: XP_038957668   ⟸   XM_039101740
- Peptide Label: isoform X2
- UniProtKB: A0A0H2UI07 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000093132   ⟸   ENSRNOT00000103387
RefSeq Acc Id: XP_063137375   ⟸   XM_063281305
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063137374   ⟸   XM_063281304
- Peptide Label: isoform X3
Protein Domains
Pyruvate kinase barrel   Pyruvate kinase C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P12928-F1-model_v2 AlphaFold P12928 1-574 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691457
Promoter ID:EPDNEW_R1982
Type:multiple initiation site
Name:Pklr_1
Description:pyruvate kinase L/R
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02188,449,661 - 188,449,721EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3336 AgrOrtholog
BioCyc Gene G2FUF-52452 BioCyc
Ensembl Genes ENSRNOG00000020420 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00065024916 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000027700.7 UniProtKB/Swiss-Prot
  ENSRNOT00000065791.3 UniProtKB/TrEMBL
  ENSRNOT00000103387 ENTREZGENE
  ENSRNOT00000103387.1 UniProtKB/Swiss-Prot
  ENSRNOT00065042893 UniProtKB/Swiss-Prot
Gene3D-CATH 2.40.33.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.20.20.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.1380.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127842 IMAGE-MGC_LOAD
InterPro Pyr_Knase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv/PenolPyrv_Kinase-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase-like_insert_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_brl UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Pyrv_Knase_insert_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24651 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:187302 IMAGE-MGC_LOAD
NCBI Gene 24651 ENTREZGENE
PANTHER PTHR11817 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PYRUVATE KINASE PKLR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00224 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PK_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pklr PhenoGen
PRINTS PYRUVTKNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE PYRUVATE_KINASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000020420 RatGTEx
  ENSRNOG00065024916 RatGTEx
Superfamily-SCOP SSF50800 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51621 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52935 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0H2UI07 ENTREZGENE, UniProtKB/TrEMBL
  A6J6C1 ENTREZGENE, UniProtKB/TrEMBL
  B1WBN9 ENTREZGENE, UniProtKB/TrEMBL
  KPYR_RAT UniProtKB/Swiss-Prot
  P04763 ENTREZGENE
  P12928 ENTREZGENE
  Q64618 ENTREZGENE
UniProt Secondary P04763 UniProtKB/Swiss-Prot
  Q64618 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-10-09 Pklr  pyruvate kinase L/R  Pklr  pyruvate kinase, liver and RBC  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-09 Pklr  pyruvate kinase, liver and RBC  Pklr  pyruvate kinase, liver and red blood cell  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Pklr  pyruvate kinase, liver and red blood cell      Name updated 1299863 APPROVED
2002-06-10 Pklr  pyruvate kinase, liver and RBC      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an N-terminal phosphorylation site 633541
gene_expression expressed in liver, kidney and small intestine 633544
gene_transcript three mRNA species of 2kb, 2.2kb and 3.2kb due to alternate sites of endonucleolytic cleavage in the 3' non-translated region 633544