Pak3 (p21 (RAC1) activated kinase 3) - Rat Genome Database

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Gene: Pak3 (p21 (RAC1) activated kinase 3) Rattus norvegicus
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Symbol: Pak3
Name: p21 (RAC1) activated kinase 3
RGD ID: 3251
Description: Enables GTPase binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA biosynthetic process; positive regulation of dendritic spine morphogenesis; and positive regulation of fibroblast migration. Located in endosome. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 30. Orthologous to human PAK3 (p21 (RAC1) activated kinase 3); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; renal cell carcinoma pathway; T cell receptor signaling pathway; INTERACTS WITH (R)-noradrenaline; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-PAK; p21 (CDKN1A)-activated kinase 3; p21 protein (Cdc42/Rac)-activated kinase 3; p21-activated kinase 3; p21/Cdc42/Rac1-activated kinase 3 (yeast Ste20-related); p65-PAK; PAK-3; serine/threonine-protein kinase PAK 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X111,912,967 - 112,171,037 (+)NCBIGRCr8
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX109,398,307 - 109,506,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X112,897,991 - 113,005,870 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X110,452,018 - 110,559,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,734,814 - 34,842,093 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X34,788,282 - 34,895,562 (-)NCBI
CeleraX106,660,352 - 106,767,478 (+)NCBICelera
Cytogenetic MapXq33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
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Original Reference(s)
Pak3Ratretinal degeneration  ISOPak3 (Mus musculus)7775028mRNA and protein:increased expression:retinaRGD 
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Pak3Ratautistic disorder  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Pak3Ratautosomal hemophilia A  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: AUTOSOMAL HEMOPHILIA AClinVarPMID:31690835
Pak3Ratdevelopmental and epileptic encephalopathy 36  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Developmental and epileptic encephalopathy and 36ClinVarPMID:28492532
Pak3Ratfactor VIII deficiency  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Factor 8 deficiency and congenitalClinVarPMID:31690835
Pak3Ratgenetic disease  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:24556213 more ...
Pak3Ratintellectual disability  ISOPAK3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:18523455 and PMID:25741868
Pak3Ratmicrocephaly  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: MicrocephalyClinVar 
Pak3Ratmucopolysaccharidosis type IIIB  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Mucopolysaccharidosis type IIIB (Sanfilippo B)ClinVarPMID:25666757 more ...
Pak3Ratnon-syndromic X-linked intellectual disability  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Non-syndromic X-linked intellectual disabilityClinVar 
Pak3Ratnon-syndromic X-linked intellectual disability 30  ISOPAK3 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:10946356 more ...
Pak3Ratschizophrenia  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106 and PMID:30208311
Pak3Ratsyndromic X-linked intellectual disability Lubs type  ISOPAK3 (Homo sapiens)8554872ClinVar Annotator: match by term: Syndromic X-linked intellectual disability Lubs typeClinVarPMID:25741868
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Pak3Ratnon-syndromic X-linked intellectual disability 30  ISOPAK3 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
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Pak3Ratnon-syndromic X-linked intellectual disability 30  ISSPak3 (Mus musculus)13592920OMIM:300558MouseDO 
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Pak3Ratnon-syndromic X-linked intellectual disability 30  ISOPAK3 (Homo sapiens)7240710 OMIM 

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Pak3Rat(R)-noradrenaline decreases expressionEXP 6480464Norepinephrine results in decreased expression of PAK3 mRNACTDPMID:14618266
Pak3Rat1,2-dichloroethane increases expressionISOPak3 (Mus musculus)6480464ethylene dichloride results in increased expression of PAK3 mRNACTDPMID:28960355
Pak3Rat1,2-dimethylhydrazine decreases expressionISOPak3 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of PAK3 mRNACTDPMID:22206623
Pak3Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of PAK3 mRNACTDPMID:29097150
Pak3Rat17beta-estradiol multiple interactionsISOPAK3 (Homo sapiens)6480464[Estradiol co-treated with TGFB1 protein] results in increased expression of PAK3 mRNACTDPMID:30165855
Pak3Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOPak3 (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of PAK3 mRNACTDPMID:19933214
Pak3Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of PAK3 mRNACTDPMID:32109520
Pak3Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOPak3 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of PAK3 mRNACTDPMID:21570461
Pak3Rat2,3-dimethoxynaphthalene-1,4-dione increases expressionISOPAK3 (Homo sapiens)64804642 more ...CTDPMID:19031421
Pak3Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOPak3 (Mus musculus)64804642 more ...CTDPMID:38648751
Pak3Rat2-palmitoylglycerol increases expressionISOPAK3 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of PAK3 mRNACTDPMID:37199045
Pak3Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of PAK3 mRNACTDPMID:24780913
Pak3Ratactinomycin D multiple interactionsISOPAK3 (Homo sapiens)6480464[Dactinomycin co-treated with nutlin 3] results in increased expression of PAK3 mRNACTDPMID:38460933
Pak3Rataflatoxin B1 decreases methylationISOPAK3 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of PAK3 geneCTDPMID:27153756
Pak3Rataflatoxin B1 increases expressionISOPak3 (Mus musculus)6480464Aflatoxin B1 results in increased expression of PAK3 mRNACTDPMID:28789997
Pak3Rataldehydo-D-glucose decreases expressionISOPak3 (Mus musculus)6480464Glucose results in decreased expression of PAK3 mRNACTDPMID:17178593
Pak3Ratall-trans-retinoic acid decreases expressionISOPAK3 (Homo sapiens)6480464Tretinoin results in decreased expression of PAK3 mRNACTDPMID:21934132
Pak3Ratall-trans-retinoic acid multiple interactionsISOPAK3 (Homo sapiens)6480464[Tretinoin co-treated with arsenic trioxide] results in decreased expression of PAK3 mRNACTDPMID:15894607
Pak3Rataristolochic acids increases expressionEXP 6480464Aristolochic Acids results in increased expression of PAK3 mRNACTDPMID:19717638
Pak3Ratarsenite(3-) decreases expressionISOPak3 (Mus musculus)6480464arsenite results in decreased expression of PAK3 mRNACTDPMID:18191166

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Biological Process
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Pak3Rataxonogenesis involved_inISSUniProtKB:Q610361600115GO_REF:0000024UniProtGO_REF:0000024
Pak3Rataxonogenesis involved_inISOPak3 (Mus musculus)1624291 PMID:21115725RGDPMID:21115725
Pak3Ratcell migration involved_inIBAFB:FBgn0044826 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pak3Ratcellular response to starvation involved_inIBACGD:CAL0000192143 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pak3Ratdendrite development involved_inISSUniProtKB:Q610361600115GO_REF:0000024UniProtGO_REF:0000024
Pak3Ratdendrite development involved_inISOPak3 (Mus musculus)1624291 PMID:21115725RGDPMID:21115725
Pak3Ratdendritic spine development acts_upstream_of_or_withinISOPak3 (Mus musculus)1624291MGI:95564 PMID:23509247RGDPMID:23509247
Pak3Ratdendritic spine morphogenesis involved_inISSUniProtKB:Q610361600115GO_REF:0000024UniProtGO_REF:0000024
Pak3Ratdendritic spine morphogenesis involved_inISOPak3 (Mus musculus)1624291 PMID:25851601RGDPMID:25851601
Pak3Ratintracellular signal transduction  TAS 70317 RGD 
Pak3Ratintracellular signal transduction involved_inIBACGD:CAL0000187689 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pak3RatMAPK cascade involved_inIEAGO:00047081600115GO_REF:0000108GOCGO_REF:0000108
Pak3Ratpositive regulation of dendritic spine morphogenesis  IMP 7775053 RGD 
Pak3Ratpositive regulation of DNA biosynthetic process  IMP 7775030 RGD 
Pak3Ratpositive regulation of fibroblast migration  IMP 10412710 RGD 
Pak3Ratpositive regulation of neuron apoptotic process  IMP 7775030 RGD 
Pak3Ratprotein phosphorylation  IDA 7775047 RGD 
Pak3Ratprotein phosphorylation  IDA 730063 RGD 
Pak3Ratregulation of actin cytoskeleton organization  IMP 10412710 RGD 
Pak3Ratregulation of actin cytoskeleton organization involved_inIBAPANTHER:PTN002807757 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
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Pak3Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Pak3Ratcytoplasm is_active_inIBAFB:FBgn0010909 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Pak3Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Pak3Ratendosome  IDA 7775030 RGD 
Pak3Ratglutamatergic synapse is_active_inISOPak3 (Mus musculus)1624291 PMID:15182717 and PMID:25851601RGDPMID:15182717 and PMID:25851601
Pak3Ratpostsynaptic density is_active_inISOPak3 (Mus musculus)1624291 PMID:15182717RGDPMID:15182717

Molecular Function
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Pak3RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Pak3RatATP binding enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Pak3RatATP binding enablesIEAInterPro:IPR000719 and InterPro:IPR0174411600115GO_REF:0000002InterProGO_REF:0000002
Pak3RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Pak3Ratcatalytic activity enablesIEAUniProtKB-KW:KW-00211600115GO_REF:0000043UniProtGO_REF:0000043
Pak3RatGTPase binding  IDA 729464Rac1 and Cdc42RGD 
Pak3Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Pak3RatMAP kinase kinase activity enablesISSUniProtKB:O759141600115GO_REF:0000024UniProtGO_REF:0000024
Pak3RatMAP kinase kinase activity enablesISOPAK3 (Homo sapiens)1624291 PMID:21177870RGDPMID:21177870
Pak3Ratmetal ion binding enablesIEAUniProtKB-KW:KW-04791600115GO_REF:0000043UniProtGO_REF:0000043
Pak3Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Pak3Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Pak3Ratprotein binding enablesISOPAK3 (Homo sapiens) and UniProtKB:O75914-21624291UniProtKB:Q9H4E5 and PMID:32296183RGDPMID:32296183
Pak3Ratprotein binding enablesISOPak3 (Mus musculus)1624291UniProtKB:P60953 more ...RGDPMID:23022564 and PMID:7493928
Pak3Ratprotein binding enablesISOPAK3 (Homo sapiens)1624291UniProtKB:P60953-2 and PMID:11157984RGDPMID:11157984
Pak3Ratprotein kinase activity  IDA 729464 RGD 
Pak3Ratprotein kinase activity enablesIEAInterPro:IPR000719 and InterPro:IPR0082711600115GO_REF:0000002InterProGO_REF:0000002
Pak3Ratprotein kinase activity enablesISOPak3 (Mus musculus)1624291 PMID:23509247RGDPMID:23509247
Pak3Ratprotein serine kinase activity enablesIEARHEA:179891600115GO_REF:0000116RHEAGO_REF:0000116
Pak3Ratprotein serine/threonine kinase activity  IDA 730063 RGD 
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Imported Annotations - KEGG (archival)

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Pak3Ratepidermal growth factor/neuregulin signaling pathway   IEA 6907045 KEGGrno:04012
Pak3Ratrenal cell carcinoma pathway   IEA 6907045 KEGGrno:05211
Pak3RatT cell receptor signaling pathway  IEA 6907045 KEGGrno:04660

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#
Reference Title
Reference Citation
1. Light-Induced photoreceptor degeneration in the mouse involves activation of the small GTPase Rac1. Belmonte MA, etal., Invest Ophthalmol Vis Sci. 2006 Mar;47(3):1193-200.
2. Distinct, but compensatory roles of PAK1 and PAK3 in spine morphogenesis. Boda B, etal., Hippocampus. 2008;18(9):857-61. doi: 10.1002/hipo.20451.
3. The mental retardation protein PAK3 contributes to synapse formation and plasticity in hippocampus. Boda B, etal., J Neurosci. 2004 Dec 1;24(48):10816-25.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. p21-activated kinase 3 (PAK3) is an AP-1 regulated gene contributing to actin organisation and migration of transformed fibroblasts. Holderness Parker N, etal., PLoS One. 2013 Jun 20;8(6):e66892. doi: 10.1371/journal.pone.0066892. Print 2013.
6. Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart. Kim SO, etal., J Cell Biochem 1998 Nov 1;71(2):286-301.
7. The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. King AJ, etal., Nature. 1998 Nov 12;396(6707):180-3.
8. Molecular cloning of a new member of the p21-Cdc42/Rac-activated kinase (PAK) family. Manser E, etal., J Biol Chem 1995 Oct 20;270(42):25070-8.
9. A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Manser E, etal., Nature 1994 Jan 6;367(6458):40-6.
10. DNA synthesis and neuronal apoptosis caused by familial Alzheimer disease mutants of the amyloid precursor protein are mediated by the p21 activated kinase PAK3. McPhie DL, etal., J Neurosci. 2003 Jul 30;23(17):6914-27.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Synapsin I is phosphorylated at Ser603 by p21-activated kinases (PAKs) in vitro and in PC12 cells stimulated with bradykinin. Sakurada K, etal., J Biol Chem 2002 Nov 22;277(47):45473-9.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Rat thy-1 antigens from thymus and brain: their tissue distribution, purification, and chemical composition. Williams AF, etal., Cold Spring Harb Symp Quant Biol 1977;41 Pt 1:51-61.
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PMID:10075701   PMID:10445846   PMID:11278486   PMID:11517222   PMID:15182717   PMID:17060906   PMID:17537723   PMID:21115725   PMID:21177870   PMID:22238087   PMID:23509247   PMID:25851601  
PMID:26460013   PMID:30053369  



Pak3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X111,912,967 - 112,171,037 (+)NCBIGRCr8
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX109,398,307 - 109,506,166 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X112,897,991 - 113,005,870 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X110,452,018 - 110,559,437 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X34,734,814 - 34,842,093 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1X34,788,282 - 34,895,562 (-)NCBI
CeleraX106,660,352 - 106,767,478 (+)NCBICelera
Cytogenetic MapXq33NCBI
PAK3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X110,944,397 - 111,227,361 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX110,944,285 - 111,227,361 (+)EnsemblGRCh38hg38GRCh38
GRCh37X110,187,625 - 110,470,589 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X110,226,256 - 110,350,816 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X110,145,744 - 110,270,305NCBI
CeleraX110,667,132 - 110,943,790 (+)NCBICelera
Cytogenetic MapXq23NCBI
HuRefX99,807,691 - 100,086,683 (+)NCBIHuRef
CHM1_1X110,098,857 - 110,375,673 (+)NCBICHM1_1
T2T-CHM13v2.0X109,392,559 - 109,675,560 (+)NCBIT2T-CHM13v2.0
Pak3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X142,301,370 - 142,580,792 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX142,301,587 - 142,580,792 (+)EnsemblGRCm39 Ensembl
GRCm38X143,518,366 - 143,797,796 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX143,518,591 - 143,797,796 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X140,127,830 - 140,226,347 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X138,912,113 - 139,038,179 (+)NCBIMGSCv36mm8
CeleraX127,648,772 - 127,747,962 (+)NCBICelera
Cytogenetic MapXF2NCBI
cM MapX64.5NCBI
Pak3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554904,545,457 - 4,662,862 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554904,538,933 - 4,833,851 (-)NCBIChiLan1.0ChiLan1.0
PAK3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X110,434,847 - 110,720,349 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X110,438,452 - 110,723,954 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X100,060,647 - 100,345,491 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X110,672,659 - 110,804,815 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX110,672,664 - 110,797,992 (+)Ensemblpanpan1.1panPan2
PAK3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X84,074,146 - 84,335,699 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX84,074,001 - 84,329,951 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX70,164,167 - 70,430,936 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X85,871,706 - 85,997,455 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X83,206,488 - 83,474,638 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X84,896,488 - 85,157,976 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X84,724,769 - 84,986,483 (+)NCBIUU_Cfam_GSD_1.0
Pak3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X83,329,189 - 83,584,851 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364994,079,103 - 4,188,774 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364994,079,127 - 4,328,580 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAK3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX90,942,077 - 91,238,565 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X90,941,976 - 91,244,331 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
PAK3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X98,743,525 - 99,031,056 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX98,911,447 - 99,027,769 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606524,135,627 - 24,263,134 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pak3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248034,392,511 - 4,513,101 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248034,386,035 - 4,700,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Pak3
754 total Variants

Predicted Target Of
Summary Value
Count of predictions:122
Count of miRNA genes:84
Interacting mature miRNAs:107
Transcripts:ENSRNOT00000006459
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 9 of 9 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1598872Memor14Memory QTL 144.5exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X93956491138956491Rat
1598856Memor1Memory QTL 11.9exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)X103312877148312877Rat
1598809Memor15Memory QTL 154.4exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X103312877148312877Rat
738025Stresp3Stress response QTL 34.610.0066stress-related behavior trait (VT:0010451)defensive burying - approachX100567703150256146Rat
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X14843113120568734Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X65612192120568734Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX41304447112935181Rat
724551Glom1Glomerulus QTL 12.80.0004kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)X75294106120294106Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X41052407146860749Rat

1 to 9 of 9 rows
DXRat19  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8X112,089,413 - 112,089,579 (+)Marker Load Pipeline
mRatBN7.2X107,292,714 - 107,292,880 (+)MAPPERmRatBN7.2
Rnor_6.0X114,961,056 - 114,961,221NCBIRnor6.0
Rnor_5.0X113,414,256 - 113,414,421UniSTSRnor5.0
RGSC_v3.4X34,810,261 - 34,810,426UniSTSRGSC3.4
RGSC_v3.4X34,810,260 - 34,810,426RGDRGSC3.4
RGSC_v3.1X34,863,730 - 34,863,895RGD
CeleraX106,691,934 - 106,692,099UniSTS
RH 3.4 Map71130.82UniSTS
RH 3.4 Map71130.82RGD
SHRSP x BN MapX30.9RGD
SHRSP x BN MapX30.9UniSTS
Cytogenetic MapXq14UniSTS
U39738  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X107,367,951 - 107,368,145 (+)MAPPERmRatBN7.2
Rnor_6.0X115,036,293 - 115,036,486NCBIRnor6.0
Rnor_5.0X113,489,491 - 113,489,684UniSTSRnor5.0
RGSC_v3.4X34,734,997 - 34,735,190UniSTSRGSC3.4
CeleraX106,767,102 - 106,767,295UniSTS
Cytogenetic MapXq14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 42 113 65 63 33 24 33 6 175 88 93 37 60 30


1 to 24 of 24 rows
RefSeq Transcripts NM_001431558 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_019210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257333 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006257339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773404 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601937 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601940 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601942 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063279849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117954 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474047 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U33314 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 24 of 24 rows

Ensembl Acc Id: ENSRNOT00000006459   ⟹   ENSRNOP00000006459
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)Ensembl
Rnor_6.0 EnsemblX114,929,029 - 115,036,669 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089141   ⟹   ENSRNOP00000075221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)Ensembl
Rnor_6.0 EnsemblX114,930,457 - 115,036,409 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103683   ⟹   ENSRNOP00000077171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000103753   ⟹   ENSRNOP00000081748
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX107,260,898 - 107,368,314 (+)Ensembl
RefSeq Acc Id: NM_019210   ⟹   NP_062083
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,602 - 112,165,023 (+)NCBI
mRatBN7.2X107,260,898 - 107,368,328 (+)NCBI
Rnor_6.0X114,929,029 - 115,036,669 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
RGSC_v3.4X34,734,814 - 34,842,093 (-)RGD
CeleraX106,660,352 - 106,767,478 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257333   ⟹   XP_006257395
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,391 - 112,171,037 (+)NCBI
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,790 - 115,042,683 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257339   ⟹   XP_006257401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,656 - 112,171,037 (+)NCBI
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,792 - 115,042,683 (+)NCBI
Rnor_5.0X113,227,320 - 113,495,881 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008773404   ⟹   XP_008771626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,387 - 112,171,037 (+)NCBI
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601937   ⟹   XP_017457426
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,387 - 112,171,037 (+)NCBI
mRatBN7.2X107,261,009 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601939   ⟹   XP_017457428
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,711 - 112,171,037 (+)NCBI
mRatBN7.2X107,261,084 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601940   ⟹   XP_017457429
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X111,913,034 - 112,171,037 (+)NCBI
mRatBN7.2X107,116,309 - 107,374,342 (+)NCBI
Rnor_6.0X114,784,452 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017601942   ⟹   XP_017457431
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,387 - 112,171,037 (+)NCBI
mRatBN7.2X107,261,051 - 107,374,342 (+)NCBI
Rnor_6.0X114,927,788 - 115,042,683 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039099537   ⟹   XP_038955465
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X111,913,034 - 112,171,037 (+)NCBI
mRatBN7.2X107,116,308 - 107,374,342 (+)NCBI
RefSeq Acc Id: XM_063279842   ⟹   XP_063135912
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X111,913,034 - 112,171,037 (+)NCBI
RefSeq Acc Id: XM_063279843   ⟹   XP_063135913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X111,913,035 - 112,171,037 (+)NCBI
RefSeq Acc Id: XM_063279844   ⟹   XP_063135914
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,677 - 112,171,037 (+)NCBI
RefSeq Acc Id: XM_063279845   ⟹   XP_063135915
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X111,912,967 - 112,171,037 (+)NCBI
RefSeq Acc Id: XM_063279846   ⟹   XP_063135916
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,656 - 112,171,037 (+)NCBI
RefSeq Acc Id: XM_063279847   ⟹   XP_063135917
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,657 - 112,171,037 (+)NCBI
RefSeq Acc Id: XM_063279848   ⟹   XP_063135918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X112,057,582 - 112,171,037 (+)NCBI
RefSeq Acc Id: XM_063279849   ⟹   XP_063135919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8X111,912,993 - 112,171,037 (+)NCBI
1 to 5 of 21 rows
1 to 5 of 21 rows
RefSeq Acc Id: NP_062083   ⟸   NM_019210
- UniProtKB: Q62829 (UniProtKB/Swiss-Prot),   A6KG82 (UniProtKB/TrEMBL),   A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257395   ⟸   XM_006257333
- Peptide Label: isoform X3
- UniProtKB: A0A8L2RA18 (UniProtKB/TrEMBL),   A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257401   ⟸   XM_006257339
- Peptide Label: isoform X4
- UniProtKB: Q62829 (UniProtKB/Swiss-Prot),   A6KG82 (UniProtKB/TrEMBL),   A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771626   ⟸   XM_008773404
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457429   ⟸   XM_017601940
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSQ0 (UniProtKB/TrEMBL)
- Sequence:
CRIB   Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-Q62829-F1-model_v2 AlphaFold Q62829 1-544 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 41 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-1501 BioCyc
Ensembl Genes ENSRNOG00000004676 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000006459 ENTREZGENE
  ENSRNOT00000006459.6 UniProtKB/Swiss-Prot
  ENSRNOT00000089141 ENTREZGENE
  ENSRNOT00000120615 ENTREZGENE
  ENSRNOT00000120616 ENTREZGENE
  ENSRNOT00000120617 ENTREZGENE
Gene3D-CATH 3.90.810.10 UniProtKB/Swiss-Prot
  Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
InterPro CRIB_dom UniProtKB/Swiss-Prot
  CRIB_dom_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PAK3-like UniProtKB/Swiss-Prot
  PAK_BD UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  STK_PAK3 UniProtKB/Swiss-Prot
KEGG Report rno:29433 UniProtKB/Swiss-Prot
NCBI Gene 29433 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE SAMKA-RELATED-RELATED UniProtKB/Swiss-Prot
  SERINE_THREONINE-PROTEIN KINASE PAK 3 UniProtKB/Swiss-Prot
Pfam PBD UniProtKB/Swiss-Prot
  Pkinase UniProtKB/Swiss-Prot
PhenoGen Pak3 PhenoGen
PROSITE CRIB UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004676 RatGTEx
SMART PBD UniProtKB/Swiss-Prot
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC220638
UniProt A0A8I5Y791_RAT UniProtKB/TrEMBL
  A0A8I5ZSQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2RA18 ENTREZGENE, UniProtKB/TrEMBL
  A6KG82 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-12 Pak3  p21 (RAC1) activated kinase 3  Pak3  p21 protein (Cdc42/Rac)-activated kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2009-05-27 Pak3  p21 protein (Cdc42/Rac)-activated kinase 3  Pak3  p21 (CDKN1A)-activated kinase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Pak3  p21 (CDKN1A)-activated kinase 3      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_function phosphorylates protein serine/threonine residues 61685
gene_function phosphorylates protein serine/threonine residues 70317
gene_product mitogen activated protein kinase kinase kinase family member 61685
gene_product mitogen activated protein kinase kinase kinase family member 70317
gene_protein 65 kDa 61685
gene_protein 65 kDa 70317