Mapk13 (mitogen activated protein kinase 13) - Rat Genome Database

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Gene: Mapk13 (mitogen activated protein kinase 13) Rattus norvegicus
Analyze
Symbol: Mapk13
Name: mitogen activated protein kinase 13
RGD ID: 3045
Description: Enables ATP binding activity and MAP kinase activity. Involved in protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Orthologous to human MAPK13 (mitogen-activated protein kinase 13); PARTICIPATES IN p38 MAPK signaling pathway; amyotrophic lateral sclerosis pathway; Chagas disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',5,5'-tetrachlorobiphenyl; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MAP kinase 13; MAP kinase p38 delta; MAPK 13; MGC124619; mitogen-activated protein kinase 13; mitogen-activated protein kinase p38 delta; Prkm13; stress-activated protein kinase 4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,836,979 - 6,847,197 (+)NCBIGRCr8
mRatBN7.2206,835,277 - 6,845,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,835,320 - 6,844,222 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,546,408 - 7,555,599 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,908,260 - 6,917,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,389,575 - 7,399,109 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,018,374 - 6,027,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,018,374 - 6,027,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,272,098 - 8,281,191 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,055,313 - 7,064,405 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,055,597 - 7,064,383 (+)NCBI
Celera208,389,500 - 8,398,583 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Mapk13Ratproteasome-associated autoinflammatory syndrome 1  ISOMAPK13 (Homo sapiens)8554872ClinVar Annotator: match by term: Proteasome-associated autoinflammatory syndrome 1ClinVarPMID:28492532
Object Symbol
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Reference
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Original Reference(s)
Mapk13Ratcholestasis  ISOMAPK13 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20626112

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Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Mapk13Rat(1->4)-beta-D-glucan multiple interactionsISOMapk13 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of MAPK13 mRNACTDPMID:36331819
Mapk13Rat(S)-nicotine decreases expressionISOMapk13 (Mus musculus)6480464Nicotine results in decreased expression of MAPK13 mRNACTDPMID:17135361
Mapk13Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane decreases expressionISOMAPK13 (Homo sapiens)6480464o and p'-DDT results in decreased expression of MAPK13 mRNACTDPMID:19371625
Mapk13Rat1,2-dimethylhydrazine multiple interactionsISOMapk13 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of MAPK13 mRNACTDPMID:22206623
Mapk13Rat14-Deoxy-11,12-didehydroandrographolide decreases expressionISOMAPK13 (Homo sapiens)648046414-deoxy-11 and 12-didehydroandrographolide results in decreased expression of MAPK13 mRNACTDPMID:22101062
Mapk13Rat17alpha-ethynylestradiol increases expressionISOMapk13 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of MAPK13 mRNACTDPMID:17942748
Mapk13Rat17alpha-ethynylestradiol increases expressionEXP 6480464Ethinyl Estradiol results in increased expression of MAPK13 mRNACTDPMID:17557909
Mapk13Rat17beta-estradiol increases expressionISOMapk13 (Mus musculus)6480464Estradiol results in increased expression of MAPK13 mRNACTDPMID:19484750
Mapk13Rat17beta-estradiol multiple interactionsISOMAPK13 (Homo sapiens)6480464IGF1R mutant form inhibits the reaction [Estradiol results in increased expression of MAPK13 mRNA]CTDPMID:23094148
Mapk13Rat17beta-estradiol increases expressionISOMAPK13 (Homo sapiens)6480464Estradiol results in increased expression of MAPK13 mRNACTDPMID:23094148
Mapk13Rat2,2',5,5'-tetrachlorobiphenyl increases expressionEXP 64804642 more ...CTDPMID:23829299
Mapk13Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMAPK13 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in increased expression of MAPK13 mRNACTDPMID:23152189
Mapk13Rat2-hydroxypropanoic acid decreases expressionISOMAPK13 (Homo sapiens)6480464Lactic Acid results in decreased expression of MAPK13 mRNACTDPMID:30851411
Mapk13Rat3-chloropropane-1,2-diol decreases expressionEXP 6480464alpha-Chlorohydrin results in decreased expression of MAPK13 mRNACTDPMID:28522335
Mapk13Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOMAPK13 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in decreased expression of MAPK13 mRNACTDPMID:28628672
Mapk13Rat4,4'-sulfonyldiphenol increases expressionISOMapk13 (Mus musculus)6480464bisphenol S results in increased expression of MAPK13 mRNACTDPMID:30951980
Mapk13Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of MAPK13 mRNACTDPMID:36041667
Mapk13Rat4-hydroxyphenyl retinamide increases expressionISOMapk13 (Mus musculus)6480464Fenretinide results in increased expression of MAPK13 mRNACTDPMID:28973697
Mapk13Rat4-nitrophenol decreases expressionISOMapk13 (Mus musculus)64804644-nitrophenol results in decreased expression of MAPK13 mRNACTDPMID:34673133
Mapk13Rat5-fluorouracil increases expressionISOMAPK13 (Homo sapiens)6480464Fluorouracil results in increased expression of MAPK13 proteinCTDPMID:15585135 and PMID:16803524

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Biological Process
1 to 20 of 24 rows

  
Object Symbol
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Reference
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Original Reference(s)
Mapk13Ratcellular response to anisomycin involved_inIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratcellular response to anisomycin involved_inISOMAPK13 (Homo sapiens)1624291 PMID:9218798RGDPMID:9218798
Mapk13Ratcellular response to hydrogen peroxide involved_inIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratcellular response to hydrogen peroxide involved_inISOMAPK13 (Homo sapiens)1624291 PMID:9218798RGDPMID:9218798
Mapk13Ratcellular response to interleukin-1 involved_inIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratcellular response to interleukin-1 involved_inISOMAPK13 (Homo sapiens)1624291 PMID:9218798RGDPMID:9218798
Mapk13Ratcellular response to sodium arsenite involved_inIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratcellular response to sodium arsenite involved_inISOMAPK13 (Homo sapiens)1624291 PMID:9218798RGDPMID:9218798
Mapk13Ratcellular response to sorbitol involved_inIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratcellular response to sorbitol involved_inISOMAPK13 (Homo sapiens)1624291 PMID:9218798RGDPMID:9218798
Mapk13Ratcellular response to UV involved_inISOMAPK13 (Homo sapiens)1624291 PMID:9218798RGDPMID:9218798
Mapk13Ratcellular response to UV involved_inIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratintracellular signal transduction involved_inIBACGD:CAL0000176774 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk13RatMAPK cascade involved_inIEAInterPro:IPR0387851600115GO_REF:0000002InterProGO_REF:0000002
Mapk13Ratpositive regulation of inflammatory response involved_inISOMAPK13 (Homo sapiens)1624291 PMID:19279008RGDPMID:19279008
Mapk13Ratpositive regulation of inflammatory response involved_inIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratpositive regulation of interleukin-6 production involved_inISOMAPK13 (Homo sapiens)1624291 PMID:19279008RGDPMID:19279008
Mapk13Ratpositive regulation of interleukin-6 production involved_inIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratprotein phosphorylation  IDA 2298806 RGD 
Mapk13Ratresponse to osmotic stress involved_inISOMAPK13 (Homo sapiens)1624291 PMID:9731215RGDPMID:9731215
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Cellular Component

  
Object Symbol
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Reference
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Source
Original Reference(s)
Mapk13Ratcytoplasm is_active_inIBACGD:CAL0000197240 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Mapk13Ratnucleus is_active_inIBACGD:CAL0000197240 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033

Molecular Function
1 to 20 of 21 rows

  
Object Symbol
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Source
Original Reference(s)
Mapk13RatATP binding  IDA 2298806 RGD 
Mapk13RatATP binding enablesIEAInterPro:IPR000719 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mapk13RatATP binding enablesIEAUniProtKB-KW:KW-00671600115GO_REF:0000043UniProtGO_REF:0000043
Mapk13RatATP binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Mapk13Ratkinase activity enablesIEAUniProtKB-KW:KW-04181600115GO_REF:0000043UniProtGO_REF:0000043
Mapk13RatMAP kinase activity  IDA 2298806 RGD 
Mapk13RatMAP kinase activity enablesIEAInterPro:IPR003527 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Mapk13RatMAP kinase activity enablesIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13RatMAP kinase activity enablesIEAEC:2.7.11.241600115GO_REF:0000003UniProtGO_REF:0000003
Mapk13RatMAP kinase activity enablesISOMAPK13 (Homo sapiens)1624291 PMID:9218798 and PMID:9731215RGDPMID:9218798 and PMID:9731215
Mapk13RatMAP kinase activity enablesISSUniProtKB:O152641600115GO_REF:0000024UniProtGO_REF:0000024
Mapk13Ratnucleotide binding enablesIEAUniProtKB-KW:KW-05471600115GO_REF:0000043UniProtGO_REF:0000043
Mapk13Ratnucleotide binding enablesIEAUniRule:UR0015033411600115GO_REF:0000104UniProtGO_REF:0000104
Mapk13Ratprotein binding enablesISOMAPK13 (Homo sapiens)1624291UniProtKB:A5A3E0 more ...RGDPMID:19135240 more ...
Mapk13Ratprotein kinase activity enablesIEAInterPro:IPR0007191600115GO_REF:0000002InterProGO_REF:0000002
Mapk13Ratprotein serine kinase activity enablesIEARHEA:179891600115GO_REF:0000116RHEAGO_REF:0000116
Mapk13Ratprotein serine/threonine kinase activity enablesISOMAPK13 (Homo sapiens)1624291 PMID:12244047 and PMID:15850461RGDPMID:12244047 and PMID:15850461
Mapk13Ratprotein serine/threonine kinase activity enablesIEAUniProtKB-KW:KW-07231600115GO_REF:0000043UniProtGO_REF:0000043
Mapk13Ratprotein serine/threonine kinase activity enablesIEAUniProtKB:O15264 and ensembl:ENSP000002112871600115GO_REF:0000107EnsemblGO_REF:0000107
Mapk13Ratprotein serine/threonine kinase activity enablesIBACGD:CAL0000183747 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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RGD Manual Annotations


  
Object Symbol
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Reference
Notes
Source
Original Reference(s)
Mapk13Ratp38 MAPK signaling pathway   ISOMAPK13 (Homo sapiens)2293891 RGD 

Imported Annotations - KEGG (archival)

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#
Reference Title
Reference Citation
1. p38 MAP-kinases pathway regulation, function and role in human diseases. Cuenda A and Rousseau S, Biochim Biophys Acta. 2007 Aug;1773(8):1358-75. Epub 2007 Mar 24.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. Hu MC, etal., J Biol Chem 1999 Mar 12;274(11):7095-102.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Melatonin arrests peroxynitrite-induced tau hyperphosphorylation and the overactivation of protein kinases in rat brain. Yin J, etal., J Pineal Res. 2006 Sep;41(2):124-9.
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PMID:9218798   PMID:9731215   PMID:12244047   PMID:12477932   PMID:15729360   PMID:15850461   PMID:19279008   PMID:20826544   PMID:21227534   PMID:21420505   PMID:22506063   PMID:34814904  



Mapk13
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8206,836,979 - 6,847,197 (+)NCBIGRCr8
mRatBN7.2206,835,277 - 6,845,500 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl206,835,320 - 6,844,222 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx207,546,408 - 7,555,599 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0206,908,260 - 6,917,454 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0207,389,575 - 7,399,109 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0206,018,374 - 6,027,467 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl206,018,374 - 6,027,473 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0208,272,098 - 8,281,191 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4207,055,313 - 7,064,405 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1207,055,597 - 7,064,383 (+)NCBI
Celera208,389,500 - 8,398,583 (+)NCBICelera
Cytogenetic Map20p12NCBI
MAPK13
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38636,130,513 - 36,144,521 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl636,127,809 - 36,144,524 (+)EnsemblGRCh38hg38GRCh38
GRCh37636,098,290 - 36,112,298 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36636,206,240 - 36,215,820 (+)NCBINCBI36Build 36hg18NCBI36
Build 34636,206,239 - 36,215,820NCBI
Celera637,652,800 - 37,662,381 (+)NCBICelera
Cytogenetic Map6p21.31NCBI
HuRef635,818,129 - 35,832,173 (+)NCBIHuRef
CHM1_1636,100,011 - 36,114,054 (+)NCBICHM1_1
T2T-CHM13v2.0635,950,829 - 35,964,842 (+)NCBIT2T-CHM13v2.0
Mapk13
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391728,988,260 - 28,997,678 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1728,988,271 - 28,999,207 (+)EnsemblGRCm39 Ensembl
GRCm381728,769,286 - 28,778,704 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1728,769,297 - 28,780,233 (+)EnsemblGRCm38mm10GRCm38
MGSCv371728,906,262 - 28,915,649 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361728,496,946 - 28,506,293 (+)NCBIMGSCv36mm8
Celera1729,324,078 - 29,333,467 (+)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1715.0NCBI
Mapk13
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554373,899,950 - 3,909,114 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554373,899,988 - 3,907,781 (+)NCBIChiLan1.0ChiLan1.0
MAPK13
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2550,589,442 - 50,619,036 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1646,458,940 - 46,488,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0635,689,475 - 35,711,990 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1636,890,205 - 36,904,528 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl636,890,974 - 36,899,388 (+)Ensemblpanpan1.1panPan2
MAPK13
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1125,239,783 - 5,248,197 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl125,239,750 - 5,248,196 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha125,259,690 - 5,268,114 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0125,587,473 - 5,595,899 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl125,587,535 - 5,595,894 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1125,242,126 - 5,250,558 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0125,321,188 - 5,329,595 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0125,421,369 - 5,429,783 (+)NCBIUU_Cfam_GSD_1.0
Mapk13
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494640,741,448 - 40,748,117 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647623,212,074 - 23,218,775 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647623,212,116 - 23,218,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK13
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl731,880,638 - 31,889,455 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1731,880,643 - 31,889,586 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
MAPK13
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11735,982,749 - 35,993,956 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1735,983,430 - 35,992,468 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604436,084,986 - 36,097,950 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk13
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475421,506,369 - 21,513,801 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475421,506,086 - 21,513,803 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Mapk13
87 total Variants

Predicted Target Of
Summary Value
Count of predictions:84
Count of miRNA genes:67
Interacting mature miRNAs:72
Transcripts:ENSRNOT00000000621
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 49 112 91 90 59 25 59 6 217 96 92 45 60 31



Ensembl Acc Id: ENSRNOT00000000621   ⟹   ENSRNOP00000000621
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl206,835,320 - 6,844,222 (+)Ensembl
Rnor_6.0 Ensembl206,018,374 - 6,027,473 (+)Ensembl
RefSeq Acc Id: NM_019231   ⟹   NP_062104
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,837,019 - 6,846,114 (+)NCBI
mRatBN7.2206,835,320 - 6,844,417 (+)NCBI
Rnor_6.0206,018,374 - 6,027,467 (+)NCBI
Rnor_5.0208,272,098 - 8,281,191 (+)NCBI
RGSC_v3.4207,055,313 - 7,064,405 (+)RGD
Celera208,389,500 - 8,398,583 (+)RGD
Sequence:
RefSeq Acc Id: XM_039098625   ⟹   XP_038954553
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,836,992 - 6,847,197 (+)NCBI
mRatBN7.2206,835,277 - 6,845,500 (+)NCBI
RefSeq Acc Id: XM_063279083   ⟹   XP_063135153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,836,979 - 6,847,197 (+)NCBI
RefSeq Acc Id: XM_063279084   ⟹   XP_063135154
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8206,836,985 - 6,847,197 (+)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_062104 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954553 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135153 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135154 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD23376 (Get FASTA)   NCBI Sequence Viewer  
  AAI07850 (Get FASTA)   NCBI Sequence Viewer  
  EDL96938 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000621
GenBank Protein Q9WTY9 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_062104   ⟸   NM_019231
- UniProtKB: A6JJS2 (UniProtKB/TrEMBL),   G3V618 (UniProtKB/TrEMBL),   Q32Q45 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000000621   ⟸   ENSRNOT00000000621
RefSeq Acc Id: XP_038954553   ⟸   XM_039098625
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135153   ⟸   XM_063279083
- Peptide Label: isoform X1
- UniProtKB: Q32Q45 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063135154   ⟸   XM_063279084
- Peptide Label: isoform X3
Protein kinase

Name Modeler Protein Id AA Range Protein Structure
AF-Q9WTY9-F1-model_v2 AlphaFold Q9WTY9 1-366 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701434
Promoter ID:EPDNEW_R11958
Type:initiation region
Name:Mapk13_1
Description:mitogen activated protein kinase 13
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0206,018,368 - 6,018,428EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-4406 BioCyc
Ensembl Genes ENSRNOG00000000515 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000000621 ENTREZGENE
Gene3D-CATH Phosphorylase Kinase, domain 1 UniProtKB/Swiss-Prot
  Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7936049 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAP_kinase UniProtKB/Swiss-Prot
  MAP_kinase_CS UniProtKB/Swiss-Prot
  MAPK_p38-like UniProtKB/Swiss-Prot
  p38delta UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
MGC_CLONE MGC:124619 IMAGE-MGC_LOAD
NCBI Gene Mapk13 ENTREZGENE
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PhenoGen Mapk13 PhenoGen
PRINTS P38MAPKINASE UniProtKB/Swiss-Prot
PROSITE MAPK UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000515 RatGTEx
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt A6JJS2 ENTREZGENE, UniProtKB/TrEMBL
  G3V618 ENTREZGENE, UniProtKB/TrEMBL
  MK13_RAT UniProtKB/Swiss-Prot
  Q32Q45 ENTREZGENE, UniProtKB/TrEMBL
  Q9WTY9 ENTREZGENE
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Mapk13  mitogen activated protein kinase 13      Name updated 70584 APPROVED

Note Type Note Reference
gene_homology mouse homolog is a developmentally regulated protein kinase, and activated by stress and proinflammatory cytokines 69880