Jun (Jun proto-oncogene, AP-1 transcription factor subunit) - Rat Genome Database

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Gene: Jun (Jun proto-oncogene, AP-1 transcription factor subunit) Rattus norvegicus
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Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
RGD ID: 2943
Description: Enables several functions, including DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and HMG box domain binding activity. Involved in several processes, including cellular response to potassium ion starvation; positive regulation of apoptotic process; and positive regulation of nucleobase-containing compound metabolic process. Located in chromatin. Part of protein-containing complex. Used to study hypertension. Biomarker of depressive disorder and renal carcinoma. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human JUN (Jun proto-oncogene, AP-1 transcription factor subunit); PARTICIPATES IN Rho/Rac/Cdc42 mediated signaling pathway; adenosine signaling pathway; endothelin signaling pathway; INTERACTS WITH (+)-pilocarpine; (-)-anisomycin; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: activator protein 1; AP1; Avian sarcoma virus 17 (v-jun) oncogene homolog; Jun oncogene; jun proto-oncogene; proto-oncogene c-jun; transcription factor AP-1; transcription factor AP-1 subunit Jun; transcription factor Jun; V-jun avian sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog; v-jun sarcoma virus 17 oncogene homolog (avian)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Ciaa5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85115,009,900 - 115,012,993 (-)NCBIGRCr8
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,464,752 - 112,467,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05114,190,270 - 114,193,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05114,252,804 - 114,255,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
JunRatAlcohol-Related Disorders  IEP 405101375protein:increased expression:liverRGD 
JunRatAsphyxia  ISOJun (Mus musculus)4890002 RGD 
JunRatbreast cancer  ISORGd:7343562290479 RGD 
JunRatchronic obstructive pulmonary disease  ISOJun (Mus musculus)155663371mRNA and protein:increased expression:lung (mouse)RGD 
JunRatcolorectal adenocarcinoma  ISOJUN (Homo sapiens)13210753 RGD 
JunRatcolorectal adenoma  ISOJUN (Homo sapiens)13210753 RGD 
JunRatCOVID-19  ISOJUN (Homo sapiens)9068941mRNA:increased expression:CD14++ monocytes (human)RGDPMID:32377375 and REF_RGD_ID:32716422
JunRatdepressive disorder  IEP 2290593protein:increased expression:basolateral amygdalaRGD 
JunRatendometrial adenocarcinoma no_associationISOJUN (Homo sapiens)2290482 RGD 
JunRatendometrial carcinoma disease_progressionISOJUN (Homo sapiens)2290481 RGD 
JunRatglaucoma  ISOJUN (Homo sapiens)155630605mRNA:increased expression:optic nerve head (human)RGD 
JunRatHodgkin's lymphoma  ISOJUN (Homo sapiens)1549449 RGD 
JunRathypertension  IDA 10047414 RGD 
JunRatNasal Polyps  ISOJUN (Homo sapiens)4890001mRNA:decreased expression:nasal cavity epitheliumRGD 
JunRatOptic Nerve Injuries  IEP 10047417 RGD 
JunRatoral squamous cell carcinoma  ISOJUN (Homo sapiens)153344573mRNA and protein:increased expression:mouth (human)RGD 
JunRatosteopetrosis  ISOJun (Mus musculus)1549450 RGD 
JunRatprostate adenocarcinoma disease_progressionISOJUN (Homo sapiens)2290484 RGD 
JunRatprostate carcinoma  ISOJUN (Homo sapiens)2290480 RGD 
JunRatProstatic Neoplasms  ISOJUN (Homo sapiens)2290478 RGD 
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JunRatBreast Neoplasms  ISOJUN (Homo sapiens)8554872ClinVar Annotator: match by term: Breast neoplasmClinVar 
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JunRatangiosarcoma  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17569031
JunRatbasal cell carcinoma  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:36428691
JunRatBrain Injuries  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21549006
JunRatbrain ischemia  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17901229
JunRatBreast Neoplasms  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16298037
JunRatColonic Neoplasms  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12628520 and PMID:18283038
JunRatextrahepatic cholestasis  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28789951
JunRatHeat Stroke  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24039931
JunRathepatocellular carcinoma  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20214788
JunRathypertension  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24039778
JunRatIntestinal Polyps  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12584176
JunRatjuvenile rheumatoid arthritis  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19565504
JunRatLiver Neoplasms  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:12127263 and PMID:24183702
JunRatLung Neoplasms  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20716630
JunRatMercury Poisoning, Nervous System  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15515958
JunRatNeoplastic Cell Transformation  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:8777434 and PMID:21726611
JunRatosteosarcoma  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18645001
JunRatperipheral nervous system disease  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17686523
JunRatReperfusion Injury  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7922267
JunRatsilicosis  ISOJUN (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27621875
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JunRatpulmonary emphysema  ISSJun (Mus musculus)13592920OMIM:130700MouseDO 

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JunRat(+)-catechin decreases expressionISOJUN (Homo sapiens)6480464Catechin results in decreased expression of JUN mRNA and Catechin results in decreased expression of JUN proteinCTDPMID:23706674
JunRat(+)-catechin multiple interactionsISOJun (Mus musculus)6480464Catechin inhibits the reaction [lipopolysaccharide and E coli O55-B5 results in increased expression of and results in increased phosphorylation of JUN protein]CTDPMID:30453148
JunRat(+)-pilocarpine multiple interactionsEXP 6480464[Lithium co-treated with Pilocarpine] results in increased expression of JUN protein more ...CTDPMID:19430551 and PMID:7984056
JunRat(+)-pilocarpine increases expressionEXP 6480464Pilocarpine results in increased expression of JUN mRNACTDPMID:17971868 and PMID:7984056
JunRat(+)-Pimaric acid multiple interactionsISOJUN (Homo sapiens)6480464pimaric acid inhibits the reaction [JUN protein results in increased expression of FOS protein modified form]CTDPMID:22705379
JunRat(+)-taxifolin decreases expressionISOJUN (Homo sapiens)6480464taxifolin results in decreased expression of JUN mRNACTDPMID:17541156
JunRat(+)-Tetrandrine decreases phosphorylationISOJUN (Homo sapiens)6480464tetrandrine results in decreased phosphorylation of JUN proteinCTDPMID:30549224
JunRat(-)-alpha-phellandrene increases expressionISOJUN (Homo sapiens)6480464alpha phellandrene results in increased expression of JUN mRNACTDPMID:25075043
JunRat(-)-anisomycin multiple interactionsISOJUN (Homo sapiens)6480464Anisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein] and DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of JUN protein]CTDPMID:11278392 and PMID:32780722
JunRat(-)-anisomycin increases phosphorylationEXP 6480464Anisomycin results in increased phosphorylation of JUN proteinCTDPMID:9751194
JunRat(-)-anisomycin increases phosphorylationISOJUN (Homo sapiens)6480464Anisomycin results in increased phosphorylation of JUN proteinCTDPMID:15019843 more ...
JunRat(-)-anisomycin increases expressionISOJUN (Homo sapiens)6480464Anisomycin results in increased expression of JUN mRNACTDPMID:18241849
JunRat(-)-citrinin increases expressionISOJUN (Homo sapiens)6480464Citrinin results in increased expression of JUN mRNA and Citrinin results in increased expression of JUN proteinCTDPMID:19361540
JunRat(-)-demecolcine increases expressionISOJUN (Homo sapiens)6480464Demecolcine results in increased expression of JUN mRNACTDPMID:23649840
JunRat(-)-epigallocatechin 3-gallate increases expressionISOJUN (Homo sapiens)6480464epigallocatechin gallate results in increased expression of JUN proteinCTDPMID:12663506
JunRat(-)-epigallocatechin 3-gallate multiple interactionsISOJUN (Homo sapiens)6480464epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased phosphorylation of JUN protein]CTDPMID:31252129
JunRat(-)-selegiline increases expressionISOJUN (Homo sapiens)6480464Selegiline results in increased expression of JUN proteinCTDPMID:16099847
JunRat(-)-selegiline multiple interactionsISOJUN (Homo sapiens)6480464Selegiline inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of JUN mRNA]CTDPMID:14724376
JunRat(20R)-protopanaxadiol multiple interactionsISOJun (Mus musculus)6480464protopanaxadiol inhibits the reaction [Scopolamine results in decreased expression of JUN protein]CTDPMID:29133030
JunRat(20S)-ginsenoside Rh1 decreases activityISOJun (Mus musculus)6480464ginsenoside Rh1 results in decreased activity of JUN proteinCTDPMID:22855946

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Biological Process
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JunRatangiogenesis acts_upstream_of_or_withinIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatangiogenesis  IMP 2290550VEGF-induced corneal neovascularizationRGD 
JunRatangiogenesis acts_upstream_of_or_withinISOJun (Mus musculus)1624291 PMID:16847049RGDPMID:16847049
JunRatapoptotic process acts_upstream_ofISOJun (Mus musculus)1624291MGI:2149630 PMID:10352021RGDPMID:10352021
JunRatapoptotic process acts_upstream_ofIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRataxon regeneration acts_upstream_of_or_withinISOJun (Mus musculus)1624291MGI:2445420 PMID:15233917RGDPMID:15233917
JunRataxon regeneration acts_upstream_of_or_withinIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatcell population proliferation acts_upstream_ofIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatcell population proliferation acts_upstream_ofISOJun (Mus musculus)1624291MGI:88039 PMID:16007074RGDPMID:16007074
JunRatcellular response to anisomycin involved_inISOJun (Mus musculus)1624291 PMID:19584270RGDPMID:19584270
JunRatcellular response to anisomycin involved_inIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatcellular response to calcium ion acts_upstream_of_or_withinIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatcellular response to calcium ion acts_upstream_of_or_withinISOJun (Mus musculus)1624291 PMID:19303854RGDPMID:19303854
JunRatcellular response to hypoxia  IEP 151347626 RGD 
JunRatcellular response to lipopolysaccharide involved_inISOJUN (Sus scrofa)1624291 PMID:25110868RGDPMID:25110868
JunRatcellular response to potassium ion starvation  IMP 2290488 RGD 
JunRatcellular response to prolactin  IEP 150524325 RGD 
JunRatcellular response to zinc ion starvation  IEP 151667428 RGD 
JunRatcircadian rhythm  IEP 2293795 RGD 
JunRatDNA-templated transcription involved_inIDA 6892704PMID:16582099UniProt 
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Cellular Component
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JunRatchromatin located_inIDA 2291793 RGD 
JunRatchromatin is_active_inISOJUN (Homo sapiens)1624291 PMID:31341047RGDPMID:31341047
JunRateuchromatin located_inISOJUN (Homo sapiens)1624291 PMID:19861239RGDPMID:19861239
JunRatnucleoplasm located_inISOJUN (Homo sapiens)1624291 RGDGO_REF:0000052
JunRatnucleus located_inISOJUN (Sus scrofa)1624291 PMID:25110868RGDPMID:25110868
JunRatnucleus located_inIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
JunRatnucleus located_inISOJun (Mus musculus)1624291 PMID:12050152 and PMID:25100604RGDPMID:12050152 and PMID:25100604
JunRatnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
JunRatnucleus located_inISOJUN (Homo sapiens)1624291 PMID:12370307 more ...RGDPMID:12370307 more ...
JunRatprotein-containing complex  IDA 10047411 RGD 
JunRatRNA polymerase II transcription regulator complex part_ofISOJUN (Homo sapiens)1624291 PMID:20102225 and PMID:23661758RGDPMID:20102225 and PMID:23661758
JunRattranscription factor AP-1 complex part_ofISOJUN (Homo sapiens)1624291 PMID:10508860 more ...RGDPMID:10508860 more ...
JunRattranscription factor AP-1 complex part_ofIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRattranscription factor AP-1 complex part_ofISOJun (Mus musculus)1624291 PMID:1631061RGDPMID:1631061
JunRattranscription regulator complex part_ofIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRattranscription regulator complex part_ofISOJun (Mus musculus)1624291PR:P70288 more ...RGDPMID:12798298 more ...
JunRattranscription regulator complex part_ofIBAFB:FBgn0001291 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
JunRattranscription repressor complex part_ofISOJun (Mus musculus)1624291PR:P70288 more ...RGDPMID:17182846
JunRattranscription repressor complex part_ofIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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JunRatcAMP response element binding enablesISOJUN (Homo sapiens)1624291 PMID:19861239RGDPMID:19861239
JunRatchromatin binding enablesISOJun (Mus musculus)1624291 PMID:20442316 and PMID:23918802RGDPMID:20442316 and PMID:23918802
JunRatchromatin binding enablesIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatDNA binding enablesISOJUN (Sus scrofa)1624291 PMID:25110868RGDPMID:25110868
JunRatDNA binding enablesIEAInterPro:IPR002112 and InterPro:IPR0089171600115GO_REF:0000002InterProGO_REF:0000002
JunRatDNA binding enablesISOJun (Mus musculus)1624291 PMID:10076871 more ...RGDPMID:10076871 more ...
JunRatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
JunRatDNA binding enablesIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISOJUN (Homo sapiens)1624291 PMID:19861239 and PMID:2833704RGDPMID:19861239 and PMID:2833704
JunRatDNA-binding transcription activator activity, RNA polymerase II-specific  IMP 2290488 RGD 
JunRatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P05627 and ensembl:ENSMUSP000001027111600115GO_REF:0000107EnsemblGO_REF:0000107
JunRatDNA-binding transcription factor activity  IMP 1626699 RGD 
JunRatDNA-binding transcription factor activity enablesIEAInterPro:IPR002112 more ...1600115GO_REF:0000002InterProGO_REF:0000002
JunRatDNA-binding transcription factor activity enablesISOJUN (Homo sapiens)1624291 PMID:31341047 and PMID:9732876RGDPMID:31341047 and PMID:9732876
JunRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISOJUN (Homo sapiens)1624291 PMID:19861239 more ...RGDPMID:19861239 more ...
JunRatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0001291 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
JunRatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISOJUN (Homo sapiens)1624291 PMID:2833704RGDPMID:2833704
JunRatdouble-stranded DNA binding  IDA 1549442 RGD 
JunRatdouble-stranded DNA binding enablesIEAARBA:ARBA000278521600115GO_REF:0000117UniProtGO_REF:0000117
JunRatdouble-stranded DNA binding  IDA 1626699 RGD 
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RGD Manual Annotations


  
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JunRatRho/Rac/Cdc42 mediated signaling pathway  IMP 2293350 RGD 

Imported Annotations - SMPDB

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JunRatadenosine signaling pathway  ISOJUN (Homo sapiens)10402751 SMPDBSMP:00321
JunRatadenosine signaling pathway  ISOJUN (Homo sapiens)10402751 SMPDBSMP:00320

Imported Annotations - KEGG (archival)

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Reference Title
Reference Citation
1. Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. Alam M and Mishra R, Life Sci. 2021 Sep 1;280:119705. doi: 10.1016/j.lfs.2021.119705. Epub 2021 Jun 8.
2. Specific transcription factors prognostic for prostate cancer progression. Aoyagi K, etal., Clin Cancer Res. 1998 Sep;4(9):2153-60.
3. The Ras/Rac1/Cdc42/SEK/JNK/c-Jun cascade is a key pathway by which agonists stimulate DNA synthesis in primary cultures of rat hepatocytes. Auer KL, etal., Mol Biol Cell. 1998 Mar;9(3):561-73.
4. Prolactin receptor is associated with c-src kinase in rat liver. Berlanga JJ, etal., Mol Endocrinol. 1995 Nov;9(11):1461-7. doi: 10.1210/mend.9.11.8584023.
5. Immunohistochemical analysis of c-myc, c-jun and estrogen receptor in normal, hyperplastic and neoplastic endometrium. Bircan S, etal., Pathol Oncol Res. 2005;11(1):32-9. Epub 2005 Mar 31.
6. c-Jun has multiple enhancing activities in the novel cross talk between the androgen receptor and Ets variant gene 1 in prostate cancer. Cai C, etal., Mol Cancer Res. 2007 Jul;5(7):725-35.
7. Modulation of cellular AP-1 DNA binding activity by heat shock proteins. Carter DA FEBS Lett. 1997 Oct 13;416(1):81-5.
8. Induction of c-jun and TGF-beta 1 in Fischer 344 rats during amiodarone-induced pulmonary fibrosis. Chung WH, etal., Am J Physiol Lung Cell Mol Physiol 2001 Nov;281(5):L1180-8.
9. Impaired activation of Stat1 and c-Jun as a possible defect in macrophages of patients with active tuberculosis. Esquivel-Solis H, etal., Clin Exp Immunol. 2009 Oct;158(1):45-54.
10. Activation of cardiac c-Jun NH(2)-terminal kinases and p38-mitogen-activated protein kinases with abrupt changes in hemodynamic load. Fischer TA, etal., Hypertension. 2001 May;37(5):1222-8.
11. miR-21 Gene expression triggered by AP-1 is sustained through a double-negative feedback mechanism. Fujita S, etal., J Mol Biol. 2008 May 2;378(3):492-504. doi: 10.1016/j.jmb.2008.03.015. Epub 2008 Mar 15.
12. Genetic dissection of a rat model for rheumatoid arthritis: significant gender influences on autosomal modifier loci Furuya T, etal., Hum Mol Genet 2000 Sep 22;9(15):2241-50
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. Circadian binding activity of AP-1, a regulator of the arylalkylamine N-acetyltransferase gene in the rat pineal gland, depends on circadian Fra-2, c-Jun, and Jun-D expression and is regulated by the clock's zeitgebers. Guillaumond F, etal., J Neurochem. 2000 Oct;75(4):1398-407.
16. Selective participation of c-Jun with Fra-2/c-Fos promotes aggressive tumor phenotypes and poor prognosis in tongue cancer. Gupta S, etal., Sci Rep. 2015 Nov 19;5:16811. doi: 10.1038/srep16811.
17. Basal expression, subcellular distribution, and up-regulation of the proto-oncogene c-JUN in the rat dentate gyrus after unilateral entorhinal cortex lesion. Haas CA, etal., Neuroscience. 1997 Nov;81(1):33-45.
18. Inactivation of AP1 proteins by a nuclear serine protease precedes the onset of radiation-induced fibrosing alveolitis. Haase MG, etal., Radiat Res. 2008 May;169(5):531-42.
19. Increased expression of the receptor for activation of NF-kappaB and decreased runt-related transcription factor 2 expression in bone of rats with streptozotocin-induced diabetes. Hie M and Tsukamoto I, Int J Mol Med. 2010 Oct;26(4):611-8. doi: 10.3892/ijmm_00000506.
20. Zinc deficiency decreases osteoblasts and osteoclasts associated with the reduced expression of Runx2 and RANK. Hie M, etal., Bone. 2011 Dec;49(6):1152-9. doi: 10.1016/j.bone.2011.08.019. Epub 2011 Aug 26.
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PMID:1651323   PMID:2833704   PMID:8662824   PMID:8889548   PMID:9098922   PMID:9651196   PMID:9710592   PMID:9732876   PMID:9847304   PMID:10076871   PMID:10352021   PMID:10508860  
PMID:11053448   PMID:11146548   PMID:11804590   PMID:11818961   PMID:11860940   PMID:12050152   PMID:12064606   PMID:12490281   PMID:12791271   PMID:12798298   PMID:12857463   PMID:12869527  
PMID:12943993   PMID:14643899   PMID:14645924   PMID:14739464   PMID:15189336   PMID:15233917   PMID:15489334   PMID:15557322   PMID:15737994   PMID:15797868   PMID:15911351   PMID:16007074  
PMID:16039502   PMID:16087680   PMID:16158334   PMID:16847049   PMID:16874457   PMID:16916642   PMID:17111371   PMID:17182846   PMID:17216194   PMID:17503228   PMID:17504975   PMID:17551755  
PMID:17681951   PMID:17720185   PMID:18024959   PMID:18029144   PMID:18192274   PMID:18314492   PMID:18320311   PMID:18326819   PMID:18485334   PMID:18524853   PMID:18596606   PMID:18646529  
PMID:18782540   PMID:18846332   PMID:18854993   PMID:19041662   PMID:19080378   PMID:19194552   PMID:19225867   PMID:19238548   PMID:19303854   PMID:19404732   PMID:19439112   PMID:19477969  
PMID:19538471   PMID:19628677   PMID:19737467   PMID:19765400   PMID:19861239   PMID:20032511   PMID:20092996   PMID:20096669   PMID:20102225   PMID:20155456   PMID:20170659   PMID:20232736  
PMID:20421303   PMID:20442316   PMID:20501438   PMID:20852630   PMID:20942268   PMID:20945380   PMID:21063128   PMID:21092560   PMID:21113145   PMID:21118817   PMID:21179834   PMID:21180051  
PMID:21181362   PMID:21624330   PMID:21818553   PMID:21925583   PMID:22097274   PMID:22229265   PMID:22379036   PMID:22402332   PMID:22611921   PMID:22634325   PMID:22644775   PMID:22681889  
PMID:23027619   PMID:23382074   PMID:23398888   PMID:23506737   PMID:23585120   PMID:23818969   PMID:23870463   PMID:23918802   PMID:23992404   PMID:24225225   PMID:24342046   PMID:24375836  
1 to 10 of 13 rows



Jun
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr85115,009,900 - 115,012,993 (-)NCBIGRCr8
mRatBN7.25109,894,175 - 109,897,268 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx5112,464,752 - 112,467,841 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.05114,190,270 - 114,193,359 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.05114,252,804 - 114,255,893 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.05114,011,184 - 114,014,277 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.05117,957,730 - 117,960,823 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.45115,358,166 - 115,361,259 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.15115,363,396 - 115,365,980 (-)NCBI
Celera5108,510,040 - 108,513,133 (-)NCBICelera
Cytogenetic Map5q33NCBI
JUN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38158,780,791 - 58,784,047 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl158,776,845 - 58,784,048 (-)EnsemblGRCh38hg38GRCh38
GRCh37159,246,463 - 59,249,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36159,019,051 - 59,022,373 (-)NCBINCBI36Build 36hg18NCBI36
Build 34158,958,483 - 58,961,806NCBI
Celera157,530,296 - 57,533,618 (-)NCBICelera
Cytogenetic Map1p32.1NCBI
HuRef157,356,787 - 57,360,109 (-)NCBIHuRef
CHM1_1159,361,828 - 59,365,150 (-)NCBICHM1_1
T2T-CHM13v2.0158,659,236 - 58,662,492 (-)NCBIT2T-CHM13v2.0
Jun
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39494,937,273 - 94,940,459 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl494,937,271 - 94,940,459 (-)EnsemblGRCm39 Ensembl
GRCm38495,049,036 - 95,052,222 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl495,049,034 - 95,052,222 (-)EnsemblGRCm38mm10GRCm38
MGSCv37494,715,727 - 94,718,913 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36494,541,073 - 94,544,205 (-)NCBIMGSCv36mm8
Celera493,436,543 - 93,439,728 (-)NCBICelera
Cytogenetic Map4C5NCBI
cM Map443.34NCBI
Jun
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554641,107,598 - 1,110,326 (+)NCBIChiLan1.0ChiLan1.0
JUN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21168,063,962 - 168,067,574 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11167,218,036 - 167,219,853 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0158,042,794 - 58,045,536 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1159,747,129 - 59,750,446 (-)NCBIpanpan1.1PanPan1.1panPan2
JUN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1550,966,698 - 50,968,939 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha551,033,459 - 51,034,786 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0551,147,773 - 51,149,113 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl551,148,001 - 51,149,014 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1551,098,106 - 51,099,438 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0551,043,349 - 51,044,688 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0551,326,980 - 51,328,311 (+)NCBIUU_Cfam_GSD_1.0
Jun
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505872,379,192 - 72,381,903 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365223,035,346 - 3,036,350 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365223,034,364 - 3,037,632 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JUN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6153,685,682 - 153,687,636 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16153,686,425 - 153,687,635 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26141,231,122 - 141,232,332 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JUN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12074,204,481 - 74,207,835 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2074,205,542 - 74,206,546 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603343,155,224 - 43,158,790 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Jun
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248621,538,455 - 1,539,426 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248621,537,886 - 1,540,633 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Jun
14 total Variants


Assembly: RGSC_v3.4
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 115359921 115359922 C G snv FHL/EurMcwi (MCW), ACI/EurMcwi (MCW) View more Information


Assembly: Rnor_5.0
Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain Variant Page
5 117959485 117959486 C G snv FHL/EurMcwi (MCW), ACI/EurMcwi (MCW) View more Information

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:30
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000011731
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 45 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1331796Thshl2Thyroid stimulating hormone level QTL 22.3blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)597059760147465714Rat
1549845Scl44Serum cholesterol level QTL 446blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)540128307148607290Rat
70212Niddm25Non-insulin dependent diabetes mellitus QTL 253.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)51131345958Rat
1298070Scl18Serum cholesterol level QTL 183.7blood LDL cholesterol amount (VT:0000181)calculated plasma low density lipoprotein cholesterol level (CMO:0001245)579584860124584860Rat
634305Mamtr1Mammary tumor resistance QTL 10.0001mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)512789751113558310Rat
61452Ciaa5CIA Autoantibody QTL 53.5blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)594858972143070159Rat
1331801Rf33Renal function QTL 334.149kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)543726656129132602Rat
7411582Foco3Food consumption QTL 37.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)587468046132468046Rat
61393Bp7Blood pressure QTL 74.50.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)560293434161481680Rat
1598859Cm66Cardiac mass QTL 662heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)579584860124584860Rat

1 to 10 of 45 rows
D5Mgh23  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85115,013,533 - 115,013,661 (+)Marker Load Pipeline
mRatBN7.25109,897,808 - 109,897,936 (+)MAPPERmRatBN7.2
Rnor_6.05114,014,818 - 114,014,945NCBIRnor6.0
Rnor_5.05117,961,364 - 117,961,491UniSTSRnor5.0
RGSC_v3.45115,361,799 - 115,361,927RGDRGSC3.4
RGSC_v3.45115,361,800 - 115,361,927UniSTSRGSC3.4
RGSC_v3.15115,367,025 - 115,367,153RGD
Celera5108,513,674 - 108,513,801UniSTS
RH 3.4 Map5779.4UniSTS
RH 3.4 Map5779.4RGD
RH 2.0 Map5702.5RGD
Cytogenetic Map5q34.1UniSTS
D5Lev15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,894,810 - 109,895,102 (+)MAPPERmRatBN7.2
Rnor_6.05114,011,820 - 114,012,111NCBIRnor6.0
Rnor_5.05117,958,366 - 117,958,657UniSTSRnor5.0
RGSC_v3.45115,358,802 - 115,359,093UniSTSRGSC3.4
Celera5108,510,676 - 108,510,967UniSTS
Cytogenetic Map5q34.1UniSTS
D5Arb17  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,897,663 - 109,897,907 (+)MAPPERmRatBN7.2
Rnor_6.05114,014,673 - 114,014,916NCBIRnor6.0
Rnor_5.05117,961,219 - 117,961,462UniSTSRnor5.0
RGSC_v3.45115,361,654 - 115,361,898RGDRGSC3.4
RGSC_v3.45115,361,655 - 115,361,898UniSTSRGSC3.4
RGSC_v3.15115,366,880 - 115,367,124RGD
Celera5108,513,529 - 108,513,772UniSTS
Cytogenetic Map5q34.1UniSTS
PMC129043P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,897,364 - 109,897,655 (+)MAPPERmRatBN7.2
Rnor_6.05114,014,374 - 114,014,664NCBIRnor6.0
Rnor_5.05117,960,920 - 117,961,210UniSTSRnor5.0
RGSC_v3.45115,361,356 - 115,361,646UniSTSRGSC3.4
Celera5108,513,230 - 108,513,520UniSTS
Cytogenetic Map5q34.1UniSTS
Jun  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,896,604 - 109,897,030 (+)MAPPERmRatBN7.2
Rnor_6.05114,013,614 - 114,014,039NCBIRnor6.0
Rnor_5.05117,960,160 - 117,960,585UniSTSRnor5.0
RGSC_v3.45115,360,596 - 115,361,021UniSTSRGSC3.4
Celera5108,512,470 - 108,512,895UniSTS
Cytogenetic Map5q34.1UniSTS
RH142347  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85115,010,109 - 115,010,301 (+)Marker Load Pipeline
mRatBN7.25109,894,384 - 109,894,576 (+)MAPPERmRatBN7.2
Rnor_6.05114,011,394 - 114,011,585NCBIRnor6.0
Rnor_5.05117,957,940 - 117,958,131UniSTSRnor5.0
RGSC_v3.45115,358,376 - 115,358,567UniSTSRGSC3.4
Celera5108,510,250 - 108,510,441UniSTS
RH 3.4 Map5777.2UniSTS
Cytogenetic Map5q34.1UniSTS
PMC152658P3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,894,800 - 109,895,148 (+)MAPPERmRatBN7.2
Rnor_6.05114,011,810 - 114,012,157NCBIRnor6.0
Rnor_5.05117,958,356 - 117,958,703UniSTSRnor5.0
RGSC_v3.45115,358,792 - 115,359,139UniSTSRGSC3.4
Celera5108,510,666 - 108,511,013UniSTS
Cytogenetic Map5q34.1UniSTS
AI407572  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,894,371 - 109,894,486 (+)MAPPERmRatBN7.2
Rnor_6.05114,011,381 - 114,011,495NCBIRnor6.0
Rnor_5.05117,957,927 - 117,958,041UniSTSRnor5.0
RGSC_v3.45115,358,363 - 115,358,477UniSTSRGSC3.4
Celera5108,510,237 - 108,510,351UniSTS
RH 3.4 Map5779.4UniSTS
Cytogenetic Map5q34.1UniSTS
PMC153970P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr85115,011,131 - 115,011,286 (+)Marker Load Pipeline
mRatBN7.25109,895,405 - 109,895,561 (+)MAPPERmRatBN7.2
Rnor_6.05114,012,415 - 114,012,570NCBIRnor6.0
Rnor_5.05117,958,961 - 117,959,116UniSTSRnor5.0
RGSC_v3.45115,359,397 - 115,359,552UniSTSRGSC3.4
Celera5108,511,271 - 108,511,426UniSTS
Cytogenetic Map5q34.1UniSTS
UniSTS:256946  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,895,884 - 109,896,151 (+)MAPPERmRatBN7.2
Rnor_6.05114,012,894 - 114,013,160NCBIRnor6.0
Rnor_5.05117,959,440 - 117,959,706UniSTSRnor5.0
RGSC_v3.45115,359,876 - 115,360,142UniSTSRGSC3.4
Celera5108,511,750 - 108,512,016UniSTS
Cytogenetic Map5q34.1UniSTS
PMC55707P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25109,895,405 - 109,896,410 (+)MAPPERmRatBN7.2
Rnor_6.05114,012,415 - 114,013,419NCBIRnor6.0
Rnor_5.05117,958,961 - 117,959,965UniSTSRnor5.0
RGSC_v3.45115,359,397 - 115,360,401UniSTSRGSC3.4
Celera5108,511,271 - 108,512,275UniSTS
Cytogenetic Map5q34.1UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000011731   ⟹   ENSRNOP00000011732
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl5109,893,145 - 109,897,656 (-)Ensembl
Rnor_6.0 Ensembl5114,011,189 - 114,014,277 (-)Ensembl
RefSeq Acc Id: NM_021835   ⟹   NP_068607
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr85115,009,900 - 115,012,993 (-)NCBI
mRatBN7.25109,894,175 - 109,897,268 (-)NCBI
Rnor_6.05114,011,184 - 114,014,277 (-)NCBI
Rnor_5.05117,957,730 - 117,960,823 (-)NCBI
RGSC_v3.45115,358,166 - 115,361,259 (-)RGD
Celera5108,510,040 - 108,513,133 (-)RGD
Sequence:
Protein RefSeqs NP_068607 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH78738 (Get FASTA)   NCBI Sequence Viewer  
  CAA35041 (Get FASTA)   NCBI Sequence Viewer  
  CAA35084 (Get FASTA)   NCBI Sequence Viewer  
  EDL97766 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011732
  ENSRNOP00000011732.1
GenBank Protein P17325 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_068607   ⟸   NM_021835
- UniProtKB: P17325 (UniProtKB/Swiss-Prot),   A6JRH4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000011732   ⟸   ENSRNOT00000011731
bZIP

Name Modeler Protein Id AA Range Protein Structure
AF-P17325-F1-model_v2 AlphaFold P17325 1-334 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13693844
Promoter ID:EPDNEW_R4369
Type:multiple initiation site
Name:Jun_1
Description:Jun proto-oncogene, AP-1 transcription factor subunit
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.05114,014,339 - 114,014,399EPDNEW


1 to 30 of 30 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-40688 BioCyc
Ensembl Genes ENSRNOG00000026293 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011731 ENTREZGENE
  ENSRNOT00000011731.4 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7124370 IMAGE-MGC_LOAD
InterPro AP-1_TF_bZIP UniProtKB/Swiss-Prot
  bZIP UniProtKB/Swiss-Prot
  bZIP_sf UniProtKB/Swiss-Prot
  JNK UniProtKB/Swiss-Prot
  Leuzip_Jun UniProtKB/Swiss-Prot
  TF_DNA-bd_sf UniProtKB/Swiss-Prot
KEGG Report rno:24516 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93192 IMAGE-MGC_LOAD
NCBI Gene 24516 ENTREZGENE
PANTHER JUN TRANSCRIPTION FACTOR-RELATED UniProtKB/Swiss-Prot
  PTHR11462:SF8 UniProtKB/Swiss-Prot
Pfam bZIP_1 UniProtKB/Swiss-Prot
  Jun UniProtKB/Swiss-Prot
PharmGKB JUN RGD
PhenoGen Jun PhenoGen
PRINTS LEUZIPPRJUN UniProtKB/Swiss-Prot
PROSITE BZIP UniProtKB/Swiss-Prot
  BZIP_BASIC UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000026293 RatGTEx
SMART BRLZ UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47454 UniProtKB/Swiss-Prot
  SSF57959 UniProtKB/Swiss-Prot
UniProt A6JRH4 ENTREZGENE, UniProtKB/TrEMBL
  JUN_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 30 of 30 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-11 Jun  Jun proto-oncogene, AP-1 transcription factor subunit  Jun  jun proto-oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2011-08-02 Jun  jun proto-oncogene  Jun  Jun oncogene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Jun  Jun oncogene    v-jun sarcoma virus 17 oncogene homolog (avian)  Name updated 1299863 APPROVED
2002-11-06 Jun  v-jun sarcoma virus 17 oncogene homolog (avian)    Avian sarcoma virus 17 (v-jun) oncogene homolog  Name updated 625702 APPROVED
2002-06-10 Jun  Avian sarcoma virus 17 (v-jun) oncogene homolog      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression highly expressed in lung tissue 628503
gene_function transcription factor 628503
gene_mutations_overexpression overexpression increases gene expression involved in fibrotic tissue remodeling, such as collagen and collagenase 628503
gene_process mediates cellular proliferation 628503
gene_product member of the activator protein-1 (AP-1) family of inducible nuclear proteins 628503
gene_regulation expression is increased by the treatment of amiodarone (AM), an iodinated benzofuran derivative and effective antidysrhythmic agent 628503
gene_regulation mRNA expression induced by estrogens 729283