Hmox1 (heme oxygenase 1) - Rat Genome Database

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Gene: Hmox1 (heme oxygenase 1) Rattus norvegicus
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Symbol: Hmox1
Name: heme oxygenase 1
RGD ID: 2806
Description: Enables several functions, including arachidonic acid omega-hydroxylase activity; heme binding activity; and heme oxygenase (decyclizing) activity. Involved in several processes, including intracellular signal transduction; negative regulation of apoptotic process; and negative regulation of immune effector process. Located in caveola; endoplasmic reticulum; and nucleus. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); hepatic vascular disease (multiple); limb ischemia; and sciatic neuropathy. Biomarker of several diseases, including Sjogren's syndrome; artery disease (multiple); brain disease (multiple); liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebrovascular disease (multiple); factor VIII deficiency; lung disease (multiple); and type 2 diabetes mellitus. Orthologous to human HMOX1 (heme oxygenase 1); PARTICIPATES IN heme degradation pathway; hypertension pathway; oxidative stress response pathway; INTERACTS WITH (+)-pilocarpine; (+)-taxifolin; (R)-carnitine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: heme oxygenas; heme oxygenase; heme oxygenase (decycling) 1; heme oxygenase (decyclizing) 1; Heox; HEOXG; Hmox; Ho-1; Ho1; hsp32
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SS/Jr  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,452,365 - 13,479,823 (+)NCBIGRCr8
mRatBN7.21913,466,287 - 13,474,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,467,244 - 13,474,079 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,440,832 - 13,447,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01914,206,098 - 14,212,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,487,026 - 13,493,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,508,634 - 14,515,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,508,616 - 14,515,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,622,556 - 25,629,377 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,963,139 - 13,969,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11913,967,964 - 13,974,784 (+)NCBI
Celera1913,334,259 - 13,341,080 (+)NCBICelera
Cytogenetic Map19p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
acute chest syndrome  (ISO)
acute kidney failure  (IMP,ISO)
Acute Lung Injury  (IEP,IMP)
acute myeloid leukemia  (IEP)
adenocarcinoma  (ISO)
adenylosuccinase lyase deficiency  (ISO)
adrenoleukodystrophy  (ISO)
adult respiratory distress syndrome  (ISO)
Altitude Sickness  (IEP)
Alzheimer's disease  (ISO)
arteriosclerosis  (ISO)
asthma  (ISO)
Behcet's disease  (ISO)
berylliosis  (ISO)
Blast Crisis  (ISO)
blood coagulation disease  (ISO)
Brain Death  (IEP,IMP)
brain edema  (IEP)
Brain Hypoxia-Ischemia  (IEP)
Brain Injuries  (IEP)
brain ischemia  (IEP,IMP)
Breast Neoplasms  (ISO)
bronchiolitis obliterans  (ISO)
Carbon Monoxide Poisoning  (IDA,IEP)
Carbon Tetrachloride Poisoning  (IEP)
Cardiomegaly  (ISO)
carotid artery disease  (ISO)
carotid artery thrombosis  (ISO)
Cerebral Hemorrhage  (ISO)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (IEP,ISO)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Tubulointerstitial Nephropathy  (ISO)
colitis  (IEP,ISO)
congestive heart failure  (IMP,ISO)
contact dermatitis  (ISO)
coronary artery disease  (ISO)
Coronary Disease  (ISO)
coronary restenosis  (ISO)
cystic fibrosis  (ISO)
diabetic angiopathy  (ISO)
Diabetic Cardiomyopathies  (IEP)
Diabetic Nephropathies  (IEP)
Dilatation, Pathologic  (IDA)
Drug-Related Side Effects and Adverse Reactions  (ISO)
end stage renal disease  (ISO)
Endotoxemia  (IEP)
esophageal cancer  (IEP)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Cirrhosis  (IDA,ISO)
Experimental Mammary Neoplasms  (IDA,ISO)
Experimental Radiation Injuries  (IMP)
factor VIII deficiency  (ISO)
Fever  (IEP)
Fibrosis  (ISO)
gastroparesis  (ISO)
genetic disease  (ISO)
Graft Occlusion, Vascular  (ISO)
Growth Disorders  (ISO)
Helicobacter Infections  (ISO)
Heme Oxygenase 1 Deficiency  (ISO)
hemochromatosis  (ISS)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
Hemorrhagic Shock  (IEP,IMP)
Henoch-Schoenlein purpura  (ISO)
hepatic encephalopathy  (IEP)
hepatic veno-occlusive disease  (IDA)
hepatitis  (ISO)
hepatopulmonary syndrome  (IEP)
hepatorenal syndrome  (ISO)
hyperinsulinism  (ISO)
Hyperoxic Lung Injury  (IEP)
Hyperplasia  (ISO)
hypertension  (IDA,ISO)
hyperthyroidism  (IEP)
hypertrophic cardiomyopathy  (IEP)
ileus  (IEP)
Inflammation  (ISO)
Insulin Resistance  (ISO)
interstitial lung disease  (ISO)
Intestinal Reperfusion Injury  (IEP)
intracranial vasospasm  (IMP,ISO)
iron metabolism disease  (ISO)
ischemia  (ISO)
Kawasaki disease  (ISO)
Kidney Reperfusion Injury  (IMP)
learning disability  (ISO)
limb ischemia  (IDA)
liver disease  (ISO)
Liver Neoplasms  (ISO)
Liver Reperfusion Injury  (IEP)
lung disease  (IDA,IEP,ISO)
Lung Injury  (ISO)
Lung Neoplasms  (ISO)
Lung Reperfusion Injury  (IEP)
malaria  (ISS)
Metabolic Syndrome  (IEP)
middle cerebral artery infarction  (IDA,IEP,ISO)
myocardial infarction  (IDA,IEP)
Myocardial Ischemia  (IEP,ISO)
Myocardial Reperfusion Injury  (IDA,IEP,ISO)
Neointima  (IMP)
Neonatal Hyperbilirubinemia  (IMP)
Neoplasm Invasiveness  (ISO)
neurodegenerative disease  (ISO)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
obstructive sleep apnea  (ISO)
pancreas disease  (ISO)
Paraparesis  (IEP)
Parkinson's disease  (ISO)
Parkinsonism  (IEP)
Pathologic Constriction  (IDA)
peptic ulcer disease  (IMP)
Perennial Allergic Rhinitis  (ISO)
Pneumococcal Pneumonia  (ISO)
pneumonia  (ISO)
pneumothorax  (ISO)
portal hypertension  (IDA)
pre-eclampsia  (ISO)
Pregnancy-Induced Hypertension  (IEP)
primary biliary cholangitis  (IEP)
Prostatic Neoplasms  (ISO)
Pulmonary Edema of Mountaineers  (IEP)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
pulmonary hypertension  (IDA,IEP,ISO)
pulmonary sarcoidosis  (ISO)
pulmonary venoocclusive disease  (IEP,ISO)
renal hypertension  (IDA)
Reperfusion Injury  (IDA,IEP,IMP,ISO)
Retina Reperfusion Injury  (IEP)
retinal disease  (ISO)
retinal ischemia  (IEP)
Rhabdomyolysis  (IEP)
Right Ventricular Hypertrophy  (ISO)
sciatic neuropathy  (IDA)
sickle cell anemia  (IMP,ISO)
silicosis  (ISO)
Sjogren's syndrome  (IEP)
Spinal Cord Injuries  (IEP)
spinocerebellar ataxia type 17  (ISO)
status epilepticus  (IEP,ISO)
Stomach Neoplasms  (ISO)
Stroke  (ISO)
Subarachnoid Hemorrhage  (IEP,IMP,ISO)
systemic mastocytosis  (ISO)
Testis Reperfusion Injury  (IMP)
thrombosis  (ISO)
toxic shock syndrome  (IDA)
type 2 diabetes mellitus  (IEP,ISO)
varicocele  (ISO)
Vascular System Injuries  (ISO)
Ventricular Fibrillation  (ISO)
viral pneumonia  (ISO)
visceral leishmaniasis  (ISO)
Wounds and Injuries  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-albicanol  (ISO)
(+)-alpha-viniferin  (ISO)
(+)-catechin  (ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-pilocarpine  (EXP,ISO)
(+)-schisandrin B  (ISO)
(+)-taxifolin  (EXP,ISO)
(+)-trans-(S)-allethrin  (ISO)
(-)-citrinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(-)-selegiline  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(2,4,5-trichlorophenoxy)acetic acid  (ISO)
(25R)-cholest-5-ene-3beta,26-diol  (ISO)
(E)-cinnamyl alcohol  (ISO)
(R)-carnitine  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R)-pantothenic acid  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-AMPA  (EXP)
(S)-colchicine  (EXP,ISO)
(S)-duloxetine hydrochloride  (ISO)
(S)-naringenin  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (ISO)
(Z)-ligustilide  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1,1-trichloroethane  (ISO)
1,1-dichloroethene  (EXP)
1,10-phenanthroline  (ISO)
1,2,4-trichlorobenzene  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,2-naphthoquinone  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,3-dichloropropan-2-ol  (EXP,ISO)
1,3-dinitrobenzene  (EXP)
1,4-benzoquinone  (ISO)
1,4-dichlorobenzene  (ISO)
1,4-dithiothreitol  (ISO)
1,4-phenylenediamine  (ISO)
1-(5-isoquinolinesulfonyl)-2-methylpiperazine  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (ISO)
1-phenyl-1,2-propanedione  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP,ISO)
15-oxo-ETE  (ISO)
17-hydroxyjolkinolide B  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (ISO)
2''-galloylhyperin  (ISO)
2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalcone  (ISO)
2'-hydroxychalcone  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-bipyridine  (ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2,6-dichloroindophenol  (ISO)
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile  (EXP,ISO)
2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol  (ISO)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-galactopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-aminophenol  (ISO)
2-bromo-2-(bromomethyl)pentanedinitrile  (ISO)
2-butoxyethanol  (ISO)
2-chloroethanol  (EXP)
2-deoxy-D-glucose  (ISO)
2-hexenal  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid  (ISO)
2-nitrofluorene  (EXP)
2-palmitoylglycerol  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
20-hydroxyecdysone  (EXP)
22-Hydroxycholesterol  (ISO)
26-hydroxycholesterol  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
3,3'-diindolylmethane  (ISO)
3,4-dihydroxybenzoate  (ISO)
3,4-dihydroxybenzoic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-chloropropane-1,2-diol  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-Nitrofluoranthene  (ISO)
3-nitropropanoic acid  (EXP)
3-O-Caffeoyl-1-O-methylquinic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4,6-dioxoheptanoic acid  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP,ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-aminophenol  (ISO)
4-hydroxy-TEMPO  (EXP,ISO)
4-Hydroxybenzyl isothiocyanate  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methoxyacetophenone  (ISO)
4-nitrobenzyl bromide  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (ISO)
4-phenylbutylamine  (EXP)
5,5-diethylbarbituric acid  (ISO)
5-(2-methylpiperazine-1-sulfonyl)isoquinoline  (ISO)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-bromo-2'-deoxyuridine  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (ISO)
6-aminonicotinamide  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (EXP)
7,8-dihydroxycoumarin  (ISO)
7beta-aminocephalosporanic acid  (ISO)
7H-xanthine  (EXP)
8-Br-cAMP  (EXP)
8-bromo-3',5'-cyclic GMP  (ISO)
9,10-phenanthroquinone  (ISO)
9-cis-retinoic acid  (ISO)
9H-xanthine  (EXP)
[2,8-bis(trifluoromethyl)quinolin-4-yl]-(2-piperidyl)methanol  (ISO)
[6]-Shogaol  (ISO)
abamectin  (EXP)
acetamide  (EXP)
acetic acid  (EXP)
acetylcholine  (EXP)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (EXP,ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
AL 8810  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP)
aldrin  (ISO)
alexidine  (ISO)
all-trans-retinal  (ISO)
all-trans-retinoic acid  (ISO)
allethrin  (EXP)
allicin  (ISO)
allopurinol  (ISO)
alloxan  (EXP)
alloxanthine  (ISO)
allyl isothiocyanate  (EXP,ISO)
alpha,alpha-trehalose  (EXP)
alpha-D-galactose  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-linolenic acid  (EXP,ISO)
alpha-Solamarine  (ISO)
AM-251  (ISO)
aminoguanidine  (ISO)
amiodarone  (EXP,ISO)
amitrole  (EXP)
amlexanox  (ISO)
ammonia  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP,ISO)
ammonium hexachloroplatinate  (ISO)
ammonium hydroxide  (ISO)
ammonium sulfate  (EXP)
Ammothamnine  (EXP,ISO)
amphetamine  (EXP)
amphibole asbestos  (ISO)
amphotericin B  (ISO)
ampicillin  (ISO)
andrographolide  (EXP,ISO)
anethole  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (ISO)
antimony(0)  (ISO)
antimycin A  (ISO)
apigenin  (EXP,ISO)
apocynin  (EXP,ISO)
arachidonic acid  (EXP,ISO)
aristolochic acid A  (EXP,ISO)
aristolochic acids  (EXP)
Aroclor 1254  (ISO)
arotinoid acid  (ISO)
arsane  (EXP,ISO)
arsenic acid  (EXP)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
asbestos  (ISO)
asperuloside  (ISO)
astaxanthin  (EXP,ISO)
astemizole  (ISO)
astragaloside IV  (ISO)
atazanavir sulfate  (ISO)
atorvastatin calcium  (EXP,ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
aucubin  (ISO)
auranofin  (ISO)
aureusidin  (EXP)
Aurin  (ISO)
azoxystrobin  (ISO)
bacitracin  (EXP)
bafilomycin A1  (ISO)
baicalein  (ISO)
baicalin  (EXP,ISO)
Bandrowski's base  (ISO)
BAPTA  (ISO)
Bardoxolone methyl  (ISO)
bathocuproine disulfonic acid  (ISO)
benfotiamine  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[a]pyrene-7,8-dione  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzoic acid  (ISO)
benzoquinones  (ISO)
benzyl bromide  (ISO)
benzyl isothiocyanate  (EXP,ISO)
benzylideneacetone  (ISO)
beraprost  (EXP)
berberine  (EXP,ISO)
bergaptol  (ISO)
Bergenin  (EXP,ISO)
beta-D-glucosamine  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (EXP,ISO)
beta-tocopherol  (EXP)
betulin  (EXP)
bifenthrin  (ISO)
bilirubin IXalpha  (EXP,ISO)
biliverdin  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisdemethoxycurcumin  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
Bisphenol A glycidylmethacrylate  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
boron nitride  (ISO)
bortezomib  (EXP,ISO)
bosentan  (ISO)
bromoacetate  (ISO)
bromobenzene  (EXP,ISO)
Bromochloroacetonitrile  (ISO)
bromocriptine  (ISO)
Brusatol  (EXP,ISO)
Bucillamine  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (EXP)
butein  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (ISO)
cadmium sulfate  (ISO)
Calcimycin  (ISO)
calciol  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium dichloride  (ISO)
calcium oxalate  (ISO)
calcium(0)  (ISO)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP,ISO)
captan  (ISO)
carbamazepine  (EXP,ISO)
carbaryl  (ISO)
carbendazim  (EXP)
carbon disulfide  (EXP)
carbon monoxide  (EXP,ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carboplatin  (EXP,ISO)
carmustine  (ISO)
carnosic acid  (ISO)
Carnosol  (ISO)
carrageenan  (EXP)
carvedilol  (ISO)
catalpol  (ISO)
cefaloridine  (EXP)
celastrol  (EXP,ISO)
celecoxib  (EXP,ISO)
ceric oxide  (ISO)
cerium trichloride  (ISO)
ceruletide  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chitosan  (EXP,ISO)
chloral hydrate  (EXP)
chloramine T  (ISO)
chloroacetaldehyde  (ISO)
chloroacetic acid  (EXP)
Chloroacetonitrile  (ISO)
chlorobenzene  (EXP,ISO)
chloroethene  (ISO)
chloroform  (ISO)
chlorogenic acid  (ISO)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (EXP,ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chromium atom  (EXP,ISO)
chromium trinitrate  (ISO)
chromium trioxide  (ISO)
chromium(6+)  (EXP,ISO)
chrysin  (EXP,ISO)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cilostazol  (EXP,ISO)
cimetidine  (EXP)
cinnamyl alcohol  (ISO)
cisplatin  (EXP,ISO)
citraconic acid  (EXP,ISO)
citral  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
Clofop  (ISO)
clozapine  (ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cobalt(2+) sulfate  (ISO)
coenzyme Q10  (EXP)
colforsin daropate hydrochloride  (EXP,ISO)
colistin  (ISO)
coniferyl aldehyde  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
corilagin  (ISO)
cortisol  (ISO)
corynoline  (ISO)
coumermycin A1  (ISO)
crocidolite asbestos  (EXP,ISO)
crocin-1  (EXP)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin I  (EXP)
cumene hydroperoxide  (ISO)
Cuprizon  (EXP)
curcumin  (EXP,ISO)
cyanidin cation  (ISO)
cyanocob(III)alamin  (ISO)
cyanuric chloride  (ISO)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP,ISO)
cysteamine  (EXP)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
D-penicillamine  (ISO)
daidzein 7-O-beta-D-glucoside  (ISO)
dantrolene  (ISO)
dapagliflozin  (EXP)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deguelin  (ISO)
dehydroascorbic acid  (ISO)
dehydrocostus lactone  (ISO)
delphinidin  (EXP)
delta-tocopherol  (EXP)
demethoxycurcumin  (ISO)
Dendrobine  (ISO)
deoxycholic acid  (ISO)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP,ISO)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
Diallyltetrasulfane  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazinon  (EXP,ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
Dibromoacetonitrile  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
Dichloroacetonitrile  (ISO)
dichloroacetyl chloride  (ISO)
dichloromethane  (ISO)
dichlorvos  (ISO)
diclofenac  (EXP,ISO)
Didecyldimethylammonium  (ISO)
dieldrin  (EXP,ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethyl sulfate  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylene glycol  (EXP)
diethylstilbestrol  (EXP)
Diglycolic acid  (EXP,ISO)
dihydroactinidiolide  (ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone  (ISO)
Diisodecyl phthalate  (ISO)
dimercaprol  (ISO)
dimethyl fumarate  (EXP,ISO)
dimethyl sulfate  (ISO)
dimethyl sulfoxide  (EXP,ISO)
dimethylarsinic acid  (ISO)
dimethylarsinous acid  (ISO)
dimethyldithiocarbamate  (ISO)
dinoseb  (ISO)
dioscin  (EXP)
diosmetin  (EXP)
dioxygen  (EXP,ISO)
diphenylcyclopropenone  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diprotium oxide  (EXP,ISO)
dipyridamole  (EXP)
diquat  (ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
dithianon  (ISO)
dithionite(2-)  (ISO)
dobutamine  (EXP)
dopamine  (EXP,ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
duroquinone  (ISO)
ebselen  (EXP)
echinacoside  (ISO)
edaravone  (EXP,ISO)
elemental selenium  (EXP,ISO)
elesclomol  (ISO)
ellagic acid  (ISO)
emodin  (ISO)
enalapril  (EXP)
endosulfan  (EXP)
enflurane  (ISO)
entinostat  (ISO)
epalrestat  (ISO)
epichlorohydrin  (ISO)
epoxiconazole  (ISO)
erastin  (ISO)
erdosteine  (EXP,ISO)
ergosta-4,6,8(14),22-tetraen-3-one  (ISO)
eriodictyol  (EXP,ISO)
erythromycin A  (ISO)
esmolol  (EXP)
etacrynic acid  (ISO)
ethanol  (EXP,ISO)
ethionamide  (ISO)
ethoxyquin  (ISO)
Ethyl maltol  (ISO)
ethyl methanesulfonate  (ISO)
ethylbenzene  (EXP,ISO)
ethylene glycol bis(2-aminoethyl)tetraacetic acid  (ISO)
ethylene glycol dimethacrylate  (ISO)
eugenol  (ISO)
farnesol  (ISO)
farrerol  (ISO)
fasudil  (ISO)
felbamate  (EXP)
fenamidone  (ISO)
fenofibrate  (EXP,ISO)
fenpyroximate  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (EXP,ISO)
ferric oxide  (ISO)
ferricyanide  (EXP)
ferroheme b  (EXP,ISO)
ferrosoferric oxide  (ISO)
ferrostatin-1  (ISO)
fisetin  (ISO)
flavonol  (ISO)
fluoranthene  (ISO)
fluorescein 5-isothiocyanate  (ISO)
fluoxetine  (ISO)
fluprostenol  (ISO)
flutamide  (EXP,ISO)
fluvastatin  (EXP)
folic acid  (ISO)
formaldehyde  (EXP,ISO)
formononetin  (ISO)
fructose  (EXP,ISO)
fucoxanthin  (EXP,ISO)
fulvestrant  (EXP,ISO)
fumonisin B1  (ISO)
furan  (ISO)
furazolidone  (ISO)
furosemide  (EXP,ISO)
gabapentin  (EXP)
galactose  (EXP,ISO)
galangin  (EXP)
gallic acid  (EXP,ISO)
gallocatechin  (ISO)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP,ISO)
Ganoderiol F  (ISO)
Garcinol  (ISO)
Gastrodin  (EXP,ISO)
gedunin  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Genipin  (ISO)
genistein  (ISO)
gentamycin  (EXP,ISO)
geranial  (ISO)
Geraniin  (ISO)
geraniol  (EXP,ISO)
Gingerenone A  (ISO)
ginkgolide B  (ISO)
Ginkgolide C  (EXP)
ginsenoside Rb1  (ISO)
ginsenoside Rg1  (ISO)
Ginsenoside Rh4  (EXP,ISO)
gliclazide  (EXP,ISO)
glucose  (EXP,ISO)
glutathione  (EXP,ISO)
Glutathione ethyl ester  (ISO)
glyburide  (EXP)
glycerol  (EXP,ISO)
glycerol 2-phosphate  (EXP)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (ISO)
glyoxal  (ISO)
glyoxylic acid  (ISO)
glyphosate  (ISO)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
gossypin  (EXP)
gossypol  (EXP)
griseofulvin  (ISO)
GW 6471  (ISO)
halothane  (ISO)
harman  (ISO)
heme b  (EXP,ISO)
hemin  (EXP,ISO)
heparin  (EXP)
herbimycin  (ISO)
hesperetin  (ISO)
hesperidin  (EXP)
Hexachloro-1,3-butadiene  (EXP)
hexachlorobenzene  (EXP)
hexadecanoic acid  (EXP,ISO)
hexaflumuron  (EXP)
hexamethylene diisocyanate  (ISO)
hexanal  (ISO)
hexane  (ISO)
hydralazine  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxycitronellal  (ISO)
hydroxysafflor yellow A  (ISO)
hypochlorous acid  (ISO)
iberin  (EXP)
idarubicin  (ISO)
imidacloprid  (EXP)
imidazoles  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indirubin-3'-monoxime  (ISO)
indole-3-methanol  (EXP,ISO)
indolin-2-one  (ISO)
indoline  (ISO)
indometacin  (EXP,ISO)
iodixanol  (EXP)
iohexol  (EXP,ISO)
irinotecan  (ISO)
iron atom  (EXP,ISO)
iron dextran  (EXP,ISO)
iron dichloride  (ISO)
iron trichloride  (EXP,ISO)
iron(0)  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) citrate  (ISO)
iron(III) nitrilotriacetate  (EXP,ISO)
isobutyl nitrite  (ISO)
isoeugenol  (ISO)
isoflurane  (EXP,ISO)
isoimperatorin  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (EXP,ISO)
isoprenaline  (EXP,ISO)
isorhamnetin  (EXP,ISO)
ivermectin  (ISO)
kaempferol  (EXP,ISO)
kahweol  (ISO)
kainic acid  (EXP)
ketamine  (EXP)
ketoconazole  (EXP,ISO)
KN-93  (ISO)
KT 5720  (EXP,ISO)
L-1,4-dithiothreitol  (ISO)
L-arginine  (ISO)
L-ascorbic acid  (EXP,ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-cysteine  (ISO)
L-dehydroascorbic acid  (ISO)
L-glutamic acid  (ISO)
L-methionine  (ISO)
lactacystin  (EXP,ISO)
lactulose  (EXP)
lansoprazole  (EXP,ISO)
lapatinib  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (EXP,ISO)
lead(0)  (EXP,ISO)
lead(II) chloride  (EXP,ISO)
Leonurine  (EXP)
letrozole  (EXP)
leukotriene B4  (ISO)
leukotriene C4  (ISO)
levetiracetam  (EXP)
Licochalcone B  (ISO)
lidocaine  (EXP)
lignan  (ISO)
limonene  (ISO)
limonin  (ISO)
linagliptin  (EXP)
linalool  (ISO)
linoleic acid  (ISO)
linsidomine  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP,ISO)
lipoteichoic acid  (EXP,ISO)
lipoxin A4  (EXP)
liquiritigenin  (EXP)
liquiritin  (EXP,ISO)
liraglutide  (EXP)
lithium atom  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
lithocholic acid  (ISO)
loganin  (ISO)
loliolide  (ISO)
lopinavir  (ISO)
losartan  (EXP,ISO)
lovastatin  (ISO)
lucidenic acid N  (ISO)
Lucidenic acid P  (ISO)
Lucidone  (ISO)
lutein  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (EXP,ISO)
lysophosphatidylcholine  (ISO)
Macrosphelide B  (ISO)
magnesium dichloride  (EXP)
Magnolol  (ISO)
malaoxon  (EXP)
malathion  (EXP)
maleic acid  (EXP)
malonaldehyde  (ISO)
maneb  (EXP,ISO)
manganese atom  (EXP,ISO)
manganese(0)  (EXP,ISO)
manganese(II) chloride  (EXP,ISO)
mangiferin  (EXP)
manidipine  (ISO)
masoprocol  (EXP,ISO)
mechlorethamine  (EXP,ISO)
mefloquine  (ISO)
meglumine amidotrizoate  (EXP)
MeIQx  (ISO)
melatonin  (EXP,ISO)
menadione  (EXP,ISO)
mercaptoethanol  (ISO)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
mesalamine  (EXP,ISO)
mesoporphyrin IX  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
Methanandamide  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methotrexate  (EXP,ISO)
methyl 3,4,5-trihydroxybenzoate  (ISO)
methyl beta-cyclodextrin  (ISO)
methyl methacrylate  (ISO)
methyl methanesulfonate  (EXP,ISO)
methyl non-2-ynoate  (ISO)
methyl salicylate  (ISO)
methylarsonic acid  (EXP,ISO)
methylene blue  (EXP,ISO)
methylglyoxal  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP,ISO)
methylparaben  (ISO)
Methysticin  (ISO)
metoprolol  (EXP)
metronidazole  (ISO)
metyrapone  (EXP)
mevinphos  (EXP)
microcystin-LR  (ISO)
midostaurin  (ISO)
mifepristone  (EXP)
miquelianin  (EXP,ISO)
monascin  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monocrotaline  (EXP,ISO)
monosodium L-glutamate  (ISO)
monothioglycerol  (ISO)
montelukast  (EXP)
morin  (EXP)
morphine  (ISO)
Morroniside  (ISO)
motexafin gadolinium  (ISO)
myricetin  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP,ISO)
N-[3,5-bis(trifluoromethyl)phenyl]-5-chloro-2-hydroxybenzamide  (ISO)
N-[3-(aminomethyl)benzyl]acetamidine  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-ethyl-N-nitrosourea  (ISO)
N-isopropyl-N'-phenyl-p-phenylenediamine  (EXP)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP)
N-methylformamide  (ISO)
N-methylnicotinate  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
n-propyl gallate  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nafenopin  (ISO)
naphthalene  (EXP,ISO)
naphthalene-1,2-diol  (ISO)
naringin  (EXP,ISO)
nefazodone  (EXP)
Neferine  (ISO)
nelfinavir  (ISO)
neomycin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nifedipine  (ISO)
nilotinib  (EXP)
nimesulide  (EXP)
nitisinone  (ISO)
nitric oxide  (EXP,ISO)
nitrites  (ISO)
nitrofen  (EXP)
nitrofurantoin  (EXP)
nitrogen dioxide  (ISO)
nitroglycerin  (EXP,ISO)
nitroprusside  (EXP,ISO)
nobiletin  (EXP)
Nodosin  (EXP)
Nonidet P-40  (ISO)
Nonylphenol  (EXP)
notoginsenoside R1  (EXP,ISO)
NS-398  (EXP,ISO)
NSC 23766  (ISO)
O-acetyl-L-carnitine  (EXP)
o-xylene  (ISO)
ochratoxin A  (EXP,ISO)
Octachlorostyrene  (ISO)
octadecanoic acid  (ISO)
octreotide  (EXP)
olanzapine  (ISO)
oleanolic acid  (EXP,ISO)
oleic acid  (ISO)
Olmesartan medoxomil  (EXP)
Olprinone hydrochloride  (EXP)
omeprazole  (ISO)
Ophiopogonin D  (ISO)
organoselenium compound  (ISO)
oridonin  (EXP)
oxaliplatin  (EXP)
oxidopamine  (EXP,ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (ISO)
p-cresol  (ISO)
Pachymic acid  (ISO)
paclitaxel  (EXP)
paeoniflorin  (ISO)
Paeonol  (EXP)
Palbinone  (EXP)
palmatine  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parathion  (EXP)
pelargonidin  (ISO)
pentachlorophenol  (ISO)
pentaerythritol tetranitrate  (EXP,ISO)
pentetrazol  (ISO)
Pentoxifylline  (ISO)
perfluorodecanoic acid  (ISO)
perfluorododecanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
perfluoroundecanoic acid  (ISO)
permethrin  (EXP)
peroxides  (ISO)
peroxynitrous acid  (EXP)
phalloidin  (ISO)
phenacetin  (EXP)
phencyclidine  (EXP)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (EXP,ISO)
phenylarsonic acid  (EXP)
phenylhydrazine  (EXP)
phenylmercury acetate  (ISO)
phenytoin  (EXP,ISO)
PhIP  (EXP,ISO)
phlorizin  (ISO)
phlorizin chalcone  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phorone  (EXP,ISO)
phosgene  (ISO)
phosphane  (EXP)
physostigmine  (EXP)
phytoestrogen  (EXP)
picoxystrobin  (ISO)
pinostrobin  (ISO)
pioglitazone  (EXP,ISO)
piperine  (EXP,ISO)
piperonyl butoxide  (EXP)
pipoxolan  (ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
platycodin D  (ISO)
plumbagin  (EXP,ISO)
pluronic P-123  (ISO)
Poloxamer  (ISO)
Polpunonic acid  (ISO)
poly(I:C)  (EXP)
poly(vinylpyrrolidone)  (EXP)
polymyxin B2  (ISO)
polysorbate 40  (ISO)
potassium bromate  (ISO)
potassium chloride  (EXP)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
pravastatin  (EXP,ISO)
prazosin  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
probucol  (EXP,ISO)
procyanidin B1  (ISO)
procyanidin B2  (EXP)
procyanidin B3  (ISO)
prodigiosin  (EXP)
progesterone  (EXP,ISO)
propacetamol  (ISO)
propan-2-ol  (ISO)
propiconazole  (EXP)
propofol  (EXP)
propranolol  (ISO)
prostaglandin A1  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
protoporphyrin  (EXP)
pterostilbene  (ISO)
puerarin  (EXP,ISO)
Punicalagin  (EXP)
puromycin  (ISO)
pyrazinecarboxamide  (EXP)
pyrazoles  (EXP)
pyrethrins  (EXP)
pyridine  (EXP)
Pyridostigmine bromide  (EXP)
pyrimidifen  (ISO)
pyrithione  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyrrolidines  (EXP)
pyrroloquinoline quinone  (EXP)
quartz  (EXP)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quercetin 4'-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (EXP,ISO)
rac-lactic acid  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
raspberry ketone  (ISO)
razoxane  (ISO)
reactive oxygen species  (EXP,ISO)
resolvin D1  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
Rhynchophylline  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (EXP)
ritonavir  (ISO)
Ro 31-8220  (ISO)
roflumilast  (EXP,ISO)
rosmarinic acid  (ISO)
rotenone  (EXP,ISO)
rottlerin  (EXP,ISO)
Rutecarpine  (ISO)
rutin  (ISO)
ryanodine  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-(1,2-Dichlorovinyl)glutathione  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
S-nitrosoglutathione  (ISO)
salvianolic acid B  (EXP,ISO)
saxagliptin  (EXP)
SB 203580  (EXP,ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
SCH772984  (ISO)
scopolamine  (ISO)
selenium atom  (EXP,ISO)
serpentine asbestos  (ISO)
sesquiterpene  (ISO)
sevoflurane  (EXP,ISO)
sildenafil citrate  (EXP)
silibinin  (EXP)
silicon atom  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
sodium dodecyl sulfate  (EXP,ISO)
sodium fluoride  (EXP,ISO)
solanesol  (ISO)
Soman  (EXP)
spironolactone  (EXP)
staurosporine  (ISO)
sterigmatocystin  (EXP)
streptozocin  (EXP,ISO)
styrene  (ISO)
styrene oxide  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
sulfaphenazole  (EXP)
sulfasalazine  (EXP)
sulforaphane  (EXP,ISO)
sulfur dioxide  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
superoxide  (EXP,ISO)
surfactin  (ISO)
surfactin C  (ISO)
T-2 toxin  (ISO)
tacrine  (EXP)
tacrolimus hydrate  (EXP,ISO)
tadalafil  (EXP)
tamoxifen  (EXP,ISO)
tangeretin  (EXP,ISO)
Tanshinone I  (EXP,ISO)
taurine  (EXP,ISO)
tebufenpyrad  (ISO)
tectorigenin  (ISO)
temozolomide  (ISO)
TEMPO  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
Tesaglitazar  (EXP)
testosterone  (EXP,ISO)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetrahydropalmatine  (ISO)
tetramethylpyrazine  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
thallium sulfate  (EXP)
thapsigargin  (ISO)
thiazoles  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP,ISO)
thiostrepton  (ISO)
thiram  (ISO)
thymidine  (ISO)
thymine  (ISO)
thymoquinone  (ISO)
ticlopidine  (ISO)
tideglusib  (ISO)
tienilic acid  (ISO)
tin(II) chloride (anhydrous)  (EXP)
Tiopronin  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
tobramycin  (ISO)
toluene  (ISO)
topotecan  (EXP)
trans-anethole  (EXP)
trans-isoeugenol  (ISO)
trans-rhaponticin  (EXP)
tranylcypromine  (EXP)
triacetin  (ISO)
triacsin C  (ISO)
tributylstannane  (EXP,ISO)
Tributyltin oxide  (EXP,ISO)
tricalcium bis(phosphate)  (ISO)
tricetin  (ISO)
Tricetinidin  (EXP)
trichloroacetaldehyde  (ISO)
trichloroacetic acid  (ISO)
Trichloroacetonitrile  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
trilobatin  (EXP,ISO)
trimethylarsine oxide  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP,ISO)
Tris(1-aziridinyl)phosphine oxide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tropisetron  (EXP)
trovafloxacin  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (ISO)
undecan-2-one  (EXP,ISO)
urea  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vancomycin  (EXP,ISO)
vanillin  (ISO)
verapamil  (EXP,ISO)
verteporfin  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (EXP,ISO)
vitamin E  (EXP,ISO)
vitexin  (ISO)
warfarin  (EXP)
water  (EXP,ISO)
withaferin A  (ISO)
wortmannin  (EXP,ISO)
Xamoterol  (EXP)
Xanthatin  (ISO)
xanthohumol  (ISO)
XAV939  (ISO)
yttrium chloride  (EXP)
zearalenone  (ISO)
zidovudine  (EXP)
zinc acetate  (EXP,ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP,ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP,ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)
ziprasidone  (EXP)
ziram  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IDA)
cellular response to arsenic-containing substance  (IEA,ISO)
cellular response to cadmium ion  (IEA,ISO)
cellular response to cisplatin  (IEA,ISO)
cellular response to heat  (IEA,ISO)
cellular response to hypoxia  (IEA,ISO)
cellular response to nutrient  (IEP)
epithelial cell apoptotic process  (IEA,ISO)
erythrocyte homeostasis  (IEA,ISO)
heme catabolic process  (IBA,IDA,IEA,ISO)
heme metabolic process  (ISO)
heme oxidation  (IBA,IEA,ISO)
intracellular iron ion homeostasis  (IEA,ISO)
intracellular signal transduction  (IDA)
intrinsic apoptotic signaling pathway in response to DNA damage  (IDA)
liver regeneration  (IMP)
macroautophagy  (IEA,ISO)
multicellular organismal-level iron ion homeostasis  (IEA,ISO)
negative regulation by host of viral transcription  (ISO)
negative regulation of cell population proliferation  (IDA)
negative regulation of DNA binding  (IDA)
negative regulation of DNA-binding transcription factor activity  (IDA)
negative regulation of epithelial cell apoptotic process  (IMP)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IEA,ISO)
negative regulation of macroautophagy  (IEA,ISO)
negative regulation of mast cell cytokine production  (IDA)
negative regulation of mast cell degranulation  (IDA)
negative regulation of muscle cell apoptotic process  (IDA)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of smooth muscle cell proliferation  (IEA,IMP,ISO)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
negative regulation of viral life cycle  (ISO)
phospholipid metabolic process  (TAS)
positive regulation of angiogenesis  (IEA,IMP,ISO)
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cell migration involved in sprouting angiogenesis  (IEA,ISO)
positive regulation of epithelial cell apoptotic process  (IEA,ISO)
positive regulation of macroautophagy  (IEA,ISO)
positive regulation of smooth muscle cell proliferation  (IEA,ISO)
regulation of blood pressure  (IDA)
regulation of transcription by RNA polymerase II  (IDA)
response to 3-methylcholanthrene  (IEP)
response to arachidonic acid  (IMP)
response to estrogen  (IDA)
response to hydrogen peroxide  (IDA)
response to hypoxia  (IEP,IMP)
response to nicotine  (IEA,ISO)
response to oxidative stress  (IBA,IDA,IEA,ISO)
response to xenobiotic stimulus  (IEP)
small GTPase-mediated signal transduction  (IDA)
wound healing involved in inflammatory response  (IEA,ISO)

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
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32. Hyperglycemia in streptozotocin-induced diabetic rat increases infarct size associated with low levels of myocardial HO-1 during ischemia/reperfusion. Di Filippo C, etal., Diabetes. 2005 Mar;54(3):803-10.
33. Therapeutic effect of placenta-derived mesenchymal stem cells on hypoxic-ischemic brain damage in rats. Ding HF, etal., World J Pediatr. 2015 Feb;11(1):74-82. doi: 10.1007/s12519-014-0531-8. Epub 2014 Dec 1.
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35. Heme oxygenase (HO)-1 is upregulated in the nasal mucosa with allergic rhinitis. Elhini A, etal., Laryngoscope. 2006 Mar;116(3):446-50.
36. A microsatellite polymorphism in the heme oxygenase-1 gene promoter is associated with increased bilirubin and HDL levels but not with coronary artery disease. Endler G, etal., Thromb Haemost. 2004 Jan;91(1):155-61.
37. The protective effect of salvianolic acid B on blood-spinal cord barrier after compression spinal cord injury in rats. Fan ZK, etal., J Mol Neurosci. 2013 Nov;51(3):986-93. doi: 10.1007/s12031-013-0083-8. Epub 2013 Aug 14.
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39. Absence of heme oxygenase-1 expression in the lung parenchyma exacerbates endotoxin-induced acute lung injury and decreases surfactant protein-B levels. Fredenburgh LE, etal., Cell Mol Biol (Noisy-le-grand). 2005 Oct 3;51(5):513-20.
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45. Induction of heme oxygenase 1 attenuates placental ischemia-induced hypertension. George EM, etal., Hypertension. 2011 May;57(5):941-8. doi: 10.1161/HYPERTENSIONAHA.111.169755. Epub 2011 Mar 7.
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48. The systemic administration of oleoylethanolamide exerts neuroprotection of the nigrostriatal system in experimental Parkinsonism. Gonzalez-Aparicio R, etal., Int J Neuropsychopharmacol. 2014 Mar;17(3):455-68. doi: 10.1017/S1461145713001259. Epub 2013 Oct 29.
49. Neuroprotective role of heme-oxygenase 1 against iodoacetate-induced toxicity in rat cerebellar granule neurons: Role of bilirubin. Gonzalez-Reyes S, etal., Free Radic Res. 2009 Mar;43(3):214-23. Epub 2009 Jan 28.
50. Heme oxygenase-1 reduces murine monocrotaline-induced pulmonary inflammatory responses and resultant right ventricular overload. Goto J, etal., Antioxid Redox Signal. 2002 Aug;4(4):563-8.
51. Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha. Goven D, etal., PLoS One. 2010 May 28;5(5):e10886.
52. Dynamic Changes of Heme Oxygenase-1 in the Hippocampus of Rats After Acute Carbon Monoxide Poisoning. Guan L, etal., Arch Environ Contam Toxicol. 2010 Apr 27.
53. Induction of heme oxygenase-1 with hemin attenuates hippocampal injury in rats after acute carbon monoxide poisoning. Guan L, etal., Toxicology. 2009 Aug 3;262(2):146-52. Epub 2009 Jun 9.
54. Clinical restenosis after coronary stent implantation is associated with the heme oxygenase-1 gene promoter polymorphism and the heme oxygenase-1 +99G/C variant. Gulesserian T, etal., Clin Chem. 2005 Sep;51(9):1661-5. Epub 2005 Jul 14.
55. Effects of heme oxygenase-1 on pulmonary function and structure in rats with liver cirrhosis. Guo SB, etal., Chin Med J (Engl). 2011 Mar;124(6):918-22.
56. Transduction of PEP-1-heme oxygenase-1 fusion protein reduces myocardial ischemia/reperfusion injury in rats. He XH, etal., J Cardiovasc Pharmacol. 2013 Nov;62(5):436-42. doi: 10.1097/FJC.0b013e3182a0b638.
57. Involvement of NADPH in the interaction between heme oxygenase-1 and cytochrome P450 reductase. Higashimoto Y, etal., J Biol Chem. 2005 Jan 7;280(1):729-37. Epub 2004 Oct 31.
58. Heme oxygenase-1 inhibits rat and human breast cancer cell proliferation: mutual cross inhibition with indoleamine 2,3-dioxygenase. Hill M, etal., FASEB J. 2005 Dec;19(14):1957-68.
59. Microarray studies of genomic oxidative stress and cell cycle responses in obstructive sleep apnea. Hoffmann MS, etal., Antioxid Redox Signal. 2007 Jun;9(6):661-9.
60. Simvastatin ameliorates established pulmonary hypertension through a heme oxygenase-1 dependent pathway in rats. Hsu HH, etal., Respir Res. 2009 May 2;10:32.
61. 2-methoxycinnamaldehyde from Cinnamomum cassia reduces rat myocardial ischemia and reperfusion injury in vivo due to HO-1 induction. Hwa JS, etal., J Ethnopharmacol. 2012 Jan 31;139(2):605-15. doi: 10.1016/j.jep.2011.12.001. Epub 2011 Dec 9.
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63. Hemin prevents in-stent stenosis in rat and rabbit models by inducing heme-oxygenase-1. Hyvelin JM, etal., J Vasc Surg. 2010 Feb;51(2):417-28.
64. Dietary alpha-linolenic acid-rich formula reduces adhesion molecules in rats with experimental colitis. Ibrahim A, etal., Nutrition. 2012 Jul;28(7-8):799-802. doi: 10.1016/j.nut.2011.10.008. Epub 2012 Jan 20.
65. Heme oxygenase-1 against vascular insufficiency: roles of atherosclerotic disorders. Ishikawa K Curr Pharm Des. 2003;9(30):2489-97.
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67. Upregulation of cytoprotective defense mechanisms and hypoxia-responsive proteins imparts tolerance to acute hypobaric hypoxia. Jain K, etal., High Alt Med Biol. 2013 Mar;14(1):65-77. doi: 10.1089/ham.2012.1064.
68. Activation of hypoxia-inducible factor-1alpha via nuclear factor-kappa B in rats with chronic obstructive pulmonary disease. Jiang H, etal., Acta Biochim Biophys Sin (Shanghai). 2010 Jul;42(7):483-8. doi: 10.1093/abbs/gmq041. Epub 2010 Jun 10.
69. Heme oxygenase inhibitor restores arteriolar nitric oxide function in dahl rats. Johnson FK, etal., Hypertension 2003 Jan;41(1):149-55.
70. Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium. Juhasz B, etal., J Cell Mol Med. 2010 Aug 16.
71. Epigallocatechin-3-gallate protects kidneys from ischemia reperfusion injury by HO-1 upregulation and inhibition of macrophage infiltration. Kakuta Y, etal., Transpl Int. 2011 May;24(5):514-22. doi: 10.1111/j.1432-2277.2011.01224.x. Epub 2011 Feb 3.
72. Polymorphisms of heme oxygenase-1 and bilirubin UDP-glucuronosyltransferase genes are not associated with Kawasaki disease susceptibility. Kanai M, etal., Tohoku J Exp Med. 2003 Jul;200(3):155-9.
73. Heme: a novel inducer of MCP-1 through HO-dependent and HO-independent mechanisms. Kanakiriya SK, etal., Am J Physiol Renal Physiol 2003 Mar;284(3):F546-54.
74. Heme oxygenase-1 gene promoter polymorphism is associated with coronary artery disease in Japanese patients with coronary risk factors. Kaneda H, etal., Arterioscler Thromb Vasc Biol. 2002 Oct 1;22(10):1680-5.
75. Heme oxygenase 1 modulates thrombomodulin and endothelial protein C receptor levels to attenuate septic kidney injury. Kang K, etal., Shock. 2013 Aug;40(2):136-43. doi: 10.1097/SHK.0b013e31829d23f5.
76. Vascular insult accompanied by overexpressed heme oxygenase-1 as a pathophysiological mechanism in experimental neurolathyrism with hind-leg paraparesis. Kawaguchi K, etal., Biochem Biophys Res Commun. 2012 Nov 9;428(1):160-6. doi: 10.1016/j.bbrc.2012.10.032. Epub 2012 Oct 12.
77. Hydrogen gas reduces hyperoxic lung injury via the Nrf2 pathway in vivo. Kawamura T, etal., Am J Physiol Lung Cell Mol Physiol. 2013 May 15;304(10):L646-56. doi: 10.1152/ajplung.00164.2012. Epub 2013 Mar 8.
78. Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent. Ke B, etal., Am J Transplant. 2003 Sep;3(9):1076-82.
79. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Ke B, etal., Hum Gene Ther 2002 Oct 10;13(15):1845-57.
80. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
81. Association of susceptibility to the development of lung adenocarcinoma with the heme oxygenase-1 gene promoter polymorphism. Kikuchi A, etal., Hum Genet. 2005 Apr;116(5):354-60. Epub 2005 Feb 2.
82. Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction. Kim HB, etal., Free Radic Res. 2011 Sep;45(9):1000-12. doi: 10.3109/10715762.2011.590137. Epub 2011 Jul 5.
83. Caveolae compartmentalization of heme oxygenase-1 in endothelial cells. Kim HP, etal., FASEB J 2004 Jul;18(10):1080-9.
84. Association of reduced heme oxygenase-1 with excessive Toll-like receptor 4 expression in peripheral blood mononuclear cells in Behcet's disease. Kirino Y, etal., Arthritis Res Ther. 2008;10(1):R16. doi: 10.1186/ar2367. Epub 2008 Jan 31.
85. cDNA microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles. Koike E, etal., Toxicol Sci 2002 Jun;67(2):241-6.
86. High extracellular induced sputum haem oxygenase-1 in sarcoidosis and chronic beryllium disease. Kokturk N, etal., Eur J Clin Invest. 2009 Jul;39(7):584-90. Epub 2009 Apr 27.
87. Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways. Korashy HM, etal., Anticancer Res. 2017 Sep;37(9):4899-4909. doi: 10.21873/anticanres.11899.
88. Evaluation of the heme oxygenase-1 expression in esophagitis and esophageal cancer induced by different reflux experimental models and diethylnitrosamine. Kruel CR, etal., Acta Cir Bras. 2010 Jun;25(3):304-10.
89. Transient limb ischemia induces remote preconditioning in liver among rats: the protective role of heme oxygenase-1. Lai IR, etal., Transplantation. 2006 May 15;81(9):1311-7.
90. Expression and regulation of hemeoxygenase 1 in healthy human lung and interstitial lung disorders. Lakari E, etal., Hum Pathol. 2001 Nov;32(11):1257-63.
91. Expression of heme oxygenase-1 in response to myocardial infarction in rats. Lakkisto P, etal., J Mol Cell Cardiol. 2002 Oct;34(10):1357-65.
92. Heme oxygenase-1 mediated memorial and revivable protective effect of ischemic preconditioning on brain injury. Le LL, etal., CNS Neurosci Ther. 2013 Dec;19(12):963-8. doi: 10.1111/cns.12152. Epub 2013 Jul 22.
93. Aprotinin Inhibits Vascular Smooth Muscle Cell Inflammation and Proliferation via Induction of HO-1. Lee DH, etal., Korean J Physiol Pharmacol. 2009 Apr;13(2):123-9. Epub 2009 Apr 30.
94. Anti-asthmatic effect of Sanguisorba officinalis L. and potential role of heme oxygenase-1 in an ovalbumin-induced murine asthma model. Lee NH, etal., Int J Mol Med. 2010 Aug;26(2):201-8.
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PMID:24746951   PMID:24755082   PMID:24771067   PMID:24810525   PMID:24844779   PMID:24997248   PMID:24998947   PMID:25027760   PMID:25035109   PMID:25036135   PMID:25086213   PMID:25091807  
PMID:25148934   PMID:25175370   PMID:25224036   PMID:25234134   PMID:25236576   PMID:25264201   PMID:25268984   PMID:25343247   PMID:25448262   PMID:25452227   PMID:25460740   PMID:25471815  
PMID:25496210   PMID:25498996   PMID:25529839   PMID:25571843   PMID:25639505   PMID:25683492   PMID:25714596   PMID:25766533   PMID:25780042   PMID:25780291   PMID:25823828   PMID:25824035  
PMID:25904107   PMID:25959017   PMID:26064429   PMID:26212551   PMID:26252059   PMID:26253294   PMID:26286380   PMID:26339453   PMID:26381691   PMID:26391895   PMID:26392811   PMID:26440581  
PMID:26492285   PMID:26709780   PMID:26780163   PMID:26798657   PMID:26838179   PMID:26866373   PMID:26925775   PMID:26992040   PMID:27006750   PMID:27021411   PMID:27021659   PMID:27034737  
PMID:27138700   PMID:27187458   PMID:27220977   PMID:27280718   PMID:27391839   PMID:27432233   PMID:27442135   PMID:27499091   PMID:27545118   PMID:27590577   PMID:27658547   PMID:27662796  
PMID:27666960   PMID:27672274   PMID:27778153   PMID:27830717   PMID:27852058   PMID:27864650   PMID:28025064   PMID:28069109   PMID:28088559   PMID:28195947   PMID:28209258   PMID:28229631  
PMID:28290603   PMID:28427999   PMID:28464602   PMID:28497199   PMID:28596681   PMID:28617444   PMID:28635609   PMID:28744340   PMID:28770019   PMID:28776762   PMID:28854440   PMID:28887196  
PMID:28901391   PMID:28928429   PMID:29054681   PMID:29074371   PMID:29147465   PMID:29305861   PMID:29362850   PMID:29385400   PMID:29412163   PMID:29635898   PMID:29662895   PMID:29743446  
PMID:29749549   PMID:29956785   PMID:29996121   PMID:30013453   PMID:30213210   PMID:30412737   PMID:30578379   PMID:30867050   PMID:30977589   PMID:31046408   PMID:31279900   PMID:31400088  
PMID:31416050   PMID:31539545   PMID:31600004   PMID:31729530   PMID:31767276   PMID:32016469   PMID:32036037   PMID:32105681   PMID:32184919   PMID:32420373   PMID:32478470   PMID:32587254  
PMID:32605461   PMID:32657424   PMID:32697403   PMID:32795555   PMID:32802873   PMID:32838965   PMID:32844330   PMID:32993187   PMID:33040818   PMID:33145342   PMID:33290309   PMID:33300078  
PMID:33343809   PMID:33382068   PMID:33713981   PMID:33811899   PMID:33962830   PMID:34071287   PMID:34194603   PMID:34287609   PMID:34310894   PMID:34669875   PMID:34914307   PMID:34984919  
PMID:35163308   PMID:35720183   PMID:36227671   PMID:36764591   PMID:37030526   PMID:37169128   PMID:37169561   PMID:37257587   PMID:37678424   PMID:37818693   PMID:37919062   PMID:38087008  


Genomics

Comparative Map Data
Hmox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81913,452,365 - 13,479,823 (+)NCBIGRCr8
mRatBN7.21913,466,287 - 13,474,082 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1913,467,244 - 13,474,079 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1913,440,832 - 13,447,675 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01914,206,098 - 14,212,941 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01913,487,026 - 13,493,858 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01914,508,634 - 14,515,455 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1914,508,616 - 14,515,456 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01925,622,556 - 25,629,377 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41913,963,139 - 13,969,960 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11913,967,964 - 13,974,784 (+)NCBI
Celera1913,334,259 - 13,341,080 (+)NCBICelera
Cytogenetic Map19p11NCBI
HMOX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382235,381,096 - 35,394,207 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2235,380,361 - 35,394,214 (+)EnsemblGRCh38hg38GRCh38
GRCh372235,777,089 - 35,790,200 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362234,107,087 - 34,120,194 (+)NCBINCBI36Build 36hg18NCBI36
Build 342234,101,640 - 34,114,748NCBI
Celera2219,579,740 - 19,592,881 (+)NCBICelera
Cytogenetic Map22q12.3NCBI
HuRef2218,737,577 - 18,750,716 (+)NCBIHuRef
CHM1_12235,735,791 - 35,748,937 (+)NCBICHM1_1
T2T-CHM13v2.02235,839,114 - 35,852,226 (+)NCBIT2T-CHM13v2.0
Hmox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39875,820,246 - 75,827,221 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl875,820,249 - 75,827,217 (+)EnsemblGRCm39 Ensembl
GRCm38875,093,618 - 75,100,593 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl875,093,621 - 75,100,589 (+)EnsemblGRCm38mm10GRCm38
MGSCv37877,617,517 - 77,624,492 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36877,989,694 - 77,996,657 (+)NCBIMGSCv36mm8
Celera879,400,848 - 79,407,824 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map835.59NCBI
Hmox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540543,124,510 - 43,130,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540543,124,447 - 43,128,873 (+)NCBIChiLan1.0ChiLan1.0
HMOX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22345,322,157 - 45,335,267 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12248,018,985 - 48,034,597 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02216,388,368 - 16,401,289 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12234,230,825 - 34,244,063 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2234,230,825 - 34,244,063 (+)Ensemblpanpan1.1panPan2
HMOX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11028,744,404 - 28,751,544 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1028,743,795 - 28,751,773 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1028,683,213 - 28,689,972 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01029,531,402 - 29,538,230 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1029,530,793 - 29,539,227 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11029,255,139 - 29,261,959 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01029,565,774 - 29,572,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01029,745,379 - 29,752,300 (-)NCBIUU_Cfam_GSD_1.0
Hmox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494512,031,937 - 12,038,780 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364925,042,330 - 5,049,311 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364925,042,353 - 5,049,216 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HMOX1
(Sus scrofa - pig)
No map positions available.
HMOX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11918,144,466 - 18,157,944 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1918,144,545 - 18,157,971 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045107,791,541 - 107,805,610 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Hmox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624750342,146 - 345,887 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624750341,699 - 346,005 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Hmox1
31 total Variants
miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mirlet7drno-let-7d-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Target Of
Summary Value
Count of predictions:543
Count of miRNA genes:263
Interacting mature miRNAs:323
Transcripts:ENSRNOT00000019192
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124688055Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127355345Rat
631678Cm9Cardiac mass QTL 94.270.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)19128982497Rat
631681Cm12Cardiac mass QTL 123.330.00053heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)19128982497Rat
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131963836Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19136824771Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19136824771Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19136824771Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19136824771Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)1956937445569374Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)1956937445569374Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19218792746708701Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19218792756457239Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19231612147316121Rat
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19320477748204777Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19409615555283277Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19745724942983518Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19997775339654489Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032318023069265Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191082797043544039Rat

Markers in Region
D19Arb1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,467,860 - 13,468,069 (+)MAPPERmRatBN7.2
Rnor_6.01914,509,237 - 14,509,445NCBIRnor6.0
Rnor_5.01925,623,159 - 25,623,367UniSTSRnor5.0
RGSC_v3.41913,963,741 - 13,963,950RGDRGSC3.4
RGSC_v3.41913,963,742 - 13,963,950UniSTSRGSC3.4
RGSC_v3.11913,968,567 - 13,968,776RGD
Celera1913,334,862 - 13,335,070UniSTS
RH 3.4 Map19158.7UniSTS
RH 3.4 Map19158.7RGD
FHH x ACI Map1914.6199UniSTS
FHH x ACI Map1914.6199RGD
Cytogenetic Map19p11UniSTS
D19Mit15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,467,917 - 13,468,079 (+)MAPPERmRatBN7.2
Rnor_6.01914,509,294 - 14,509,455NCBIRnor6.0
Rnor_5.01925,623,216 - 25,623,377UniSTSRnor5.0
RGSC_v3.41913,963,798 - 13,963,960RGDRGSC3.4
RGSC_v3.41913,963,799 - 13,963,960UniSTSRGSC3.4
RGSC_v3.11913,968,624 - 13,968,786RGD
Celera1913,334,919 - 13,335,080UniSTS
RH 3.4 Map19132.88UniSTS
RH 3.4 Map19132.88RGD
RH 2.0 Map19142.4RGD
Cytogenetic Map19p11UniSTS
RH128180  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,473,638 - 13,473,849 (+)MAPPERmRatBN7.2
Rnor_6.01914,515,015 - 14,515,225NCBIRnor6.0
Rnor_5.01925,628,937 - 25,629,147UniSTSRnor5.0
RGSC_v3.41913,969,520 - 13,969,730UniSTSRGSC3.4
Celera1913,340,640 - 13,340,850UniSTS
Cytogenetic Map19p11UniSTS
UniSTS:472912  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21913,469,393 - 13,470,289 (+)MAPPERmRatBN7.2
Rnor_6.01914,510,770 - 14,511,665NCBIRnor6.0
Rnor_5.01925,624,692 - 25,625,587UniSTSRnor5.0
RGSC_v3.41913,965,275 - 13,966,170UniSTSRGSC3.4
Celera1913,336,395 - 13,337,290UniSTS
Cytogenetic Map19p11UniSTS


Related Rat Strains
The following Strains have been annotated to Hmox1
SS/Jr    


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 20 55 41 19 41 31 20 36 11
Low 2 23 2 8 11 43 15 5 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000019192   ⟹   ENSRNOP00000019192
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1913,467,244 - 13,474,079 (+)Ensembl
Rnor_6.0 Ensembl1914,508,616 - 14,515,456 (+)Ensembl
RefSeq Acc Id: NM_012580   ⟹   NP_036712
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,473,002 - 13,479,823 (+)NCBI
mRatBN7.21913,467,258 - 13,474,079 (+)NCBI
Rnor_6.01914,508,634 - 14,515,455 (+)NCBI
Rnor_5.01925,622,556 - 25,629,377 (+)NCBI
RGSC_v3.41913,963,139 - 13,969,960 (+)RGD
Celera1913,334,259 - 13,341,080 (+)RGD
Sequence:
RefSeq Acc Id: XM_039097470   ⟹   XP_038953398
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,462,343 - 13,479,823 (+)NCBI
mRatBN7.21913,466,310 - 13,474,082 (+)NCBI
RefSeq Acc Id: XM_063277775   ⟹   XP_063133845
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,462,343 - 13,479,823 (+)NCBI
RefSeq Acc Id: XM_063277776   ⟹   XP_063133846
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,462,343 - 13,479,823 (+)NCBI
RefSeq Acc Id: XM_063277777   ⟹   XP_063133847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,462,343 - 13,479,823 (+)NCBI
RefSeq Acc Id: XM_063277778   ⟹   XP_063133848
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,457,721 - 13,479,823 (+)NCBI
RefSeq Acc Id: XM_063277779   ⟹   XP_063133849
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,457,713 - 13,479,823 (+)NCBI
RefSeq Acc Id: XM_063277780   ⟹   XP_063133850
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,461,843 - 13,479,823 (+)NCBI
RefSeq Acc Id: XM_063277781   ⟹   XP_063133851
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,457,711 - 13,479,823 (+)NCBI
RefSeq Acc Id: XM_063277782   ⟹   XP_063133852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81913,452,365 - 13,479,823 (+)NCBI
RefSeq Acc Id: NP_036712   ⟸   NM_012580
- UniProtKB: Q5BK87 (UniProtKB/Swiss-Prot),   P06762 (UniProtKB/Swiss-Prot),   A6JY98 (UniProtKB/TrEMBL),   A0A8L2UJE9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000019192   ⟸   ENSRNOT00000019192
RefSeq Acc Id: XP_038953398   ⟸   XM_039097470
- Peptide Label: isoform X1
- UniProtKB: P06762 (UniProtKB/Swiss-Prot),   Q5BK87 (UniProtKB/Swiss-Prot),   A6JY98 (UniProtKB/TrEMBL),   A0A8L2UJE9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063133852   ⟸   XM_063277782
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133851   ⟸   XM_063277781
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133849   ⟸   XM_063277779
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133848   ⟸   XM_063277778
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133850   ⟸   XM_063277780
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133847   ⟸   XM_063277777
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133845   ⟸   XM_063277775
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063133846   ⟸   XM_063277776
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P06762-F1-model_v2 AlphaFold P06762 1-289 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:6849794
Promoter ID:EP31003
Type:single initiation site
Name:RN_HO1
Description:Heme oxygenase, HMOX1 gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Nuclease protection with homologous sequence ladder; Sequencing of a full-length cDNA; Nuclease protection; RNA Pol II in vitro system; low-precision; data
Regulation:spleen ; (induced by or strongly expressed in) heme, (induced by or strongly expressed in) heavy metals
Position:
Rat AssemblyChrPosition (strand)Source
RGSC_v3.41913,963,127 - 13,963,187EPD
RGD ID:13700960
Promoter ID:EPDNEW_R11484
Type:single initiation site
Name:Hmox1_1
Description:heme oxygenase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01914,508,622 - 14,508,682EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2806 AgrOrtholog
BioCyc Gene G2FUF-6420 BioCyc
BioCyc Pathway PWY-5874 [heme degradation I] BioCyc
BioCyc Pathway Image PWY-5874 BioCyc
Ensembl Genes ENSRNOG00000014117 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00055021832 UniProtKB/Swiss-Prot
  ENSRNOG00060015875 UniProtKB/Swiss-Prot
  ENSRNOG00065004008 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000019192 ENTREZGENE
  ENSRNOT00000019192.7 UniProtKB/TrEMBL
  ENSRNOT00055037437 UniProtKB/Swiss-Prot
  ENSRNOT00060027191 UniProtKB/Swiss-Prot
  ENSRNOT00065005841 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.910.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7384448 IMAGE-MGC_LOAD
InterPro Haem_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_Oase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_Oase-like_multi-hlx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Haem_oxygenase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24451 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:108752 IMAGE-MGC_LOAD
NCBI Gene 24451 ENTREZGENE
PANTHER HEME OXYGENASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10720 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Heme_oxygenase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Hmox1 PhenoGen
PIRSF Haem_Oase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS HAEMOXYGNASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE HEME_OXYGENASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014117 RatGTEx
  ENSRNOG00055021832 RatGTEx
  ENSRNOG00060015875 RatGTEx
  ENSRNOG00065004008 RatGTEx
Superfamily-SCOP SSF48613 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218454
UniProt A0A8L2UJE9 ENTREZGENE, UniProtKB/TrEMBL
  A6JY98 ENTREZGENE, UniProtKB/TrEMBL
  HMOX1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5BK87 ENTREZGENE
UniProt Secondary Q5BK87 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-04-08 Hmox1  heme oxygenase 1  Hmox1  heme oxygenase (decycling) 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Hmox1  heme oxygenase (decycling) 1    heme oxygenase 1  Name updated 1299863 APPROVED
2002-06-10 Hmox1  Heme oxygenase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease may be involved in hepatopulmonary syndrome caused by liver cirrhosis 625603
gene_expression expressed in the liver and the lung 625603
gene_function catalyzes the rate limiting stage during the oxidative degradation of heme to biliverdin 625603
gene_function catalyzes the initial and rate-limiting step in the oxidative degradation of heme to biliverdin 625603
gene_function catalyzes the initial and rate-limiting step in the oxidative degradation of heme to biliverdin 625731
gene_function cleaves heme to form biliverdin and carbon monoxide 628519
gene_function produces biliverdin-IX, divalent iron, and carbon monoxide (CO) through oxidative cleavage of protoheme-IX, the prosthetic group of cytochromes P450 625692
gene_pathway gene expression after reoxygenation (A-R) is mediated by ERK, JNK, and p38 MAPK pathways 625603
gene_process may contribute to increased hypertension in salt-sensitive Dahl rats on high-salt diet by increasing carbon monoxide which in turn decreases vascular nitric oxide (NO) formation 625603
gene_process mediates germ cell apoptosis through carbon monoxide (CO) production in Leydig cells 625692
gene_process mediates the host defense against oxidant injury 625731
gene_process provides intestinal preconditioning as a protective effect during hemorrhagic shock 625633
gene_regulation expression in the lung was increased 5 weeks after common bile duct ligation whereas in the liver after 2 weeks expression stayed elevated till 5 weeks 625603
gene_regulation expression regulated by nitric oxide 625603
gene_regulation has three isoforms, Hmox1 (HO-1) is inducible but Hmox2 (HO-2) and Hmox3 (HO-3) are primarily constitutive 625603
gene_regulation expression is induced by stress 625603
gene_regulation increased after ischemial, oxidant stress, and intestinal preconditioning; induced by heavy metals, endotoxin, heat shock, cytokines and prostaglandins 625603
gene_regulation increased vascular expression in Dahl sal-sensitive rats exposed to high-salt diet 625603