Gstt1 (glutathione S-transferase theta 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Gstt1 (glutathione S-transferase theta 1) Rattus norvegicus
Analyze
Symbol: Gstt1
Name: glutathione S-transferase theta 1
RGD ID: 2765
Description: Enables alkylhalidase activity; glutathione peroxidase activity; and glutathione transferase activity. Involved in several processes, including dichloromethane metabolic process; response to selenium ion; and response to vitamin E. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Biomarker of obesity and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); cancer (multiple); cardiovascular system disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to human GSTT1 (glutathione S-transferase theta 1); PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; (E)-1,3-dichloropropene; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glutathione S-transferase 1 (theta); glutathione S-transferase 5; glutathione S-transferase theta-1; glutathione S-transferase, theta 1; GST 5-5; GST class-theta-1; GSTYRS
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,856,068 - 12,873,020 (+)NCBIGRCr8
mRatBN7.22012,856,613 - 12,873,586 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,856,669 - 12,873,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,563,264 - 13,580,163 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,924,193 - 12,941,104 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,396,180 - 13,413,203 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,799,102 - 13,816,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,799,102 - 13,816,526 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,989,083 - 16,006,508 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,604,355 - 13,621,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,604,582 - 13,621,683 (-)NCBI
Celera2014,348,088 - 14,365,283 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


1 to 20 of 163 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstt1Ratacute chest syndrome susceptibilityISOGSTT1 (Homo sapiens)10450838associated with Anemia more ...RGD 
Gstt1Ratacute lymphoblastic leukemia susceptibilityISOGSTT1 (Homo sapiens)10755410 RGD 
Gstt1Ratacute lymphoblastic leukemia disease_progressionISOGSTT1 (Homo sapiens)10450829 RGD 
Gstt1Ratacute myeloid leukemia disease_progressionISOGSTT1 (Homo sapiens)10755318 RGD 
Gstt1Ratacute myeloid leukemia no_associationISOGSTT1 (Homo sapiens)10450779 RGD 
Gstt1Ratacute myeloid leukemia susceptibilityISOGSTT1 (Homo sapiens)10450822 RGD 
Gstt1Ratacute promyelocytic leukemia susceptibilityISOGSTT1 (Homo sapiens)10755406 RGD 
Gstt1Rataggressive periodontitis  ISOGSTT1 (Homo sapiens)14700939 RGD 
Gstt1Ratalcohol dependence  ISOGSTT1 (Homo sapiens)14700988 RGD 
Gstt1RatAlcoholic Liver Diseases  ISOGSTT1 (Homo sapiens)14700973 RGD 
Gstt1RatAlcoholic Liver Diseases  ISOGSTT1 (Homo sapiens)11060494 RGD 
Gstt1RatAlzheimer's disease susceptibilityISOGSTT1 (Homo sapiens)5490213DNA:deletion: :RGD 
Gstt1RatAlzheimer's disease onsetISOGSTT1 (Homo sapiens)5490271DNA:deletion: :RGD 
Gstt1Ratanemia  ISOGSTT1 (Homo sapiens)10450867associated with kidney transplantationRGD 
Gstt1Rataplastic anemia susceptibilityISOGSTT1 (Homo sapiens)10450790 RGD 
Gstt1Rataplastic anemia no_associationISOGSTT1 (Homo sapiens)10450878 RGD 
Gstt1Ratasthma  ISOGSTT1 (Homo sapiens)5490962 RGD 
Gstt1Ratasthma susceptibilityISOGSTT1 (Homo sapiens)4140921DNA:deletion: :RGD 
Gstt1Ratasthma  ISOGSTT1 (Homo sapiens)4142539 RGD 
Gstt1Ratatopic dermatitis  ISOGSTT1 (Homo sapiens)5490540DNA:deletion and haplotype: :RGD 
1 to 20 of 163 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstt1Ratepilepsy  ISOGSTT1 (Homo sapiens)8554872ClinVar Annotator: match by term: EpilepsyClinVar 
1 to 20 of 21 rows
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstt1Ratamphetamine abuse  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18186040 and PMID:19254865
Gstt1Ratasbestosis  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17563610
Gstt1RatAsthenozoospermia  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19303595
Gstt1Ratcarcinoma  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20663906
Gstt1RatChemical and Drug Induced Liver Injury  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18397238 more ...
Gstt1RatChromosome Aberrations  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16537716 more ...
Gstt1Ratdisease of cellular proliferation  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25325283
Gstt1RatDisease Susceptibility  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31569996
Gstt1Ratesophagus squamous cell carcinoma  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17173682
Gstt1Ratglioblastoma  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16874663
Gstt1Rathypertension  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:22228705
Gstt1RatKidney Neoplasms  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20663906
Gstt1RatLung Neoplasms  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17000715 and PMID:24852519
Gstt1Ratmetabolic dysfunction-associated steatotic liver disease  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23643483
Gstt1RatMicronuclei, Chromosome-Defective  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16702390
Gstt1Ratmultiple myeloma  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16949155
Gstt1Ratovarian carcinoma  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:31569996
Gstt1RatProstatic Neoplasms  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11275366 more ...
Gstt1RatRaynaud disease  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16977343
Gstt1Ratrenal cell carcinoma  ISOGSTT1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18566013 and PMID:26656529
1 to 20 of 21 rows

1 to 20 of 319 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstt1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTT1 mRNA]CTDPMID:31150632
Gstt1Rat(1->4)-beta-D-glucan multiple interactionsISOGstt1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GSTT1 mRNACTDPMID:36331819
Gstt1Rat(E)-1,3-dichloropropene multiple interactionsEXP 6480464GSTT1 protein affects the metabolism of and results in increased activity of 1 and 3-dichloro-1-propeneCTDPMID:15790493
Gstt1Rat(R,R,R)-alpha-tocopherol increases expressionEXP 6480464alpha-Tocopherol results in increased expression of GSTT1 proteinCTDPMID:9855024
Gstt1Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionEXP 6480464o and p'-DDT affects the expression of GSTT1 mRNACTDPMID:17984292
Gstt1Rat1,2-dibromoethane multiple interactionsISOGSTT1 (Homo sapiens)6480464GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of Ethylene Dibromide] and GSTT1 protein affects the metabolism of and results in increased activity of Ethylene DibromideCTDPMID:21781954 and PMID:8565128
Gstt1Rat1,2-dibromoethane increases activityEXP 6480464GSTT1 protein results in increased activity of Ethylene DibromideCTDPMID:12505322
Gstt1Rat1,2-dibromoethane affects response to substanceEXP 6480464GSTT1 protein affects the susceptibility to Ethylene DibromideCTDPMID:12902151
Gstt1Rat1,2-dibromoethane multiple interactionsEXP 6480464GSTT1 protein results in increased metabolism of and results in increased activity of Ethylene DibromideCTDPMID:10413528
Gstt1Rat1,2-dibromoethane increases glutathionylationISOGSTT1 (Homo sapiens)6480464GSTT1 protein results in increased glutathionylation of Ethylene DibromideCTDPMID:21781954
Gstt1Rat1,2-dibromoethane increases activityISOGSTT1 (Homo sapiens)6480464GSTT1 protein results in increased activity of Ethylene DibromideCTDPMID:19664997
Gstt1Rat1,2-dimethylhydrazine multiple interactionsISOGstt1 (Mus musculus)6480464Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in decreased expression of GSTT1 mRNA]CTDPMID:22206623
Gstt1Rat1,2-dimethylhydrazine decreases expressionISOGstt1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of GSTT1 mRNACTDPMID:22206623
Gstt1Rat1,2-epoxy-3-(4-nitrophenoxy)propane multiple interactionsEXP 6480464GSTT1 protein affects the metabolism of and results in decreased activity of 1 more ...CTDPMID:7578934 and PMID:8951341
Gstt1Rat1,2-epoxy-3-(4-nitrophenoxy)propane affects metabolic processingISOGSTT1 (Homo sapiens)6480464GSTT1 protein affects the metabolism of 1 and 2-epoxy-3-(p-nitrophenoxy)propaneCTDPMID:15683365 and PMID:15882759
Gstt1Rat1,2-epoxy-3-(4-nitrophenoxy)propane increases glutathionylationISOGSTT1 (Homo sapiens)6480464GSTT1 protein results in increased glutathionylation of 1 and 2-epoxy-3-(p-nitrophenoxy)propaneCTDPMID:19664997 and PMID:21781954
Gstt1Rat1,2-epoxy-3-(4-nitrophenoxy)propane multiple interactionsISOGSTT1 (Homo sapiens)6480464GSTT1 gene SNP inhibits the reaction [GSTT1 protein results in increased glutathionylation of 1 and 2-epoxy-3-(p-nitrophenoxy)propane]CTDPMID:21781954
Gstt1Rat1,2-epoxy-3-(4-nitrophenoxy)propane affects metabolic processingISOGstt1 (Mus musculus)6480464GSTT1 protein affects the metabolism of 1 and 2-epoxy-3-(p-nitrophenoxy)propaneCTDPMID:17827337 and PMID:9854036
Gstt1Rat1-chloro-2,4-dinitrobenzene decreases expressionISOGstt1 (Mus musculus)6480464Dinitrochlorobenzene results in decreased expression of GSTT1 mRNACTDPMID:28219650
Gstt1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of GSTT1 mRNACTDPMID:12883083

1 to 20 of 319 rows

Biological Process
1 to 13 of 13 rows

  
1 to 13 of 13 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstt1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gstt1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gstt1Ratcytoplasm is_active_inIBAMGI:106188 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstt1Ratcytosol located_inISOGstt1 (Mus musculus)1624291 PMID:15100242RGDPMID:15100242
Gstt1Ratcytosol located_inISOGSTT1 (Homo sapiens)1624291 PMID:8799324RGDPMID:8799324
Gstt1Ratcytosol located_inIEAUniProtKB:Q64471 and ensembl:ENSMUSP000000017131600115GO_REF:0000107EnsemblGO_REF:0000107

Molecular Function
1 to 12 of 12 rows

  
1 to 12 of 12 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstt1Ratglutathione conjugation pathway  ISS 1358120 RGD 

Imported Annotations - SMPDB

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstt1Ratparacetamol pharmacokinetics pathway   ISOGSTT1 (Homo sapiens)10402751 SMPDBSMP:00640

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstt1Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gstt1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gstt1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

1 to 20 of 168 rows
#
Reference Title
Reference Citation
1. GSTM1, GSTT1, GSTP1 and CYP1A1 genetic polymorphisms and susceptibility to esophageal cancer in a French population: different pattern of squamous cell carcinoma and adenocarcinoma. Abbas A, etal., World J Gastroenterol. 2004 Dec 1;10(23):3389-93.
2. T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking. Abu-Amero KK, etal., BMC Med Genet. 2006 Apr 19;7:38.
3. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Abu-Amero KK, etal., Br J Ophthalmol. 2009 Aug;93(8):1101-4. Epub 2009 Mar 13.
4. Audioprofiles and antioxidant enzyme genotypes in presbycusis. Angeli SI, etal., Laryngoscope. 2012 Nov;122(11):2539-42. doi: 10.1002/lary.23577. Epub 2012 Sep 10.
5. Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects. Arruda VR, etal., Eur J Haematol. 2001 Jun;66(6):383-8.
6. Genetic polymorphism of glutathione S transferases M1 and T1 in Indian patients with hepatocellular carcinoma. Asim M, etal., Dis Markers. 2010;28(6):369-76. doi: 10.3233/DMA-2010-0717.
7. Glutathione S-transferase gene polymorphisms in presbycusis. Ates NA, etal., Otol Neurotol. 2005 May;26(3):392-7.
8. Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma. Barahmani N, etal., Neuro Oncol. 2009 Jun;11(3):292-300. Epub 2008 Oct 24.
9. GSTT1 polymorphism and oral leukoplakia. Barroso Duarte EC, etal., Anticancer Res. 2006 Jan-Feb;26(1A):427-30.
10. Glutathione S-transferase theta 1 (GSTT1) gene defect in myelodysplasia and acute myeloid leukaemia. Basu T, etal., Lancet. 1997 May 17;349(9063):1450.
11. Glutathione S-transferase activity and subunit composition in transitional cell cancer and mucosa of the human bladder. Berendsen CL, etal., Urology. 1997 Apr;49(4):644-51.
12. Biobreeding rat islets exhibit reduced antioxidative defense and N-acetyl cysteine treatment delays type 1 diabetes. Bogdani M, etal., J Endocrinol. 2013 Jan 18;216(2):111-23. doi: 10.1530/JOE-12-0385. Print 2013 Feb.
13. Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis. Bohanec Grabar P, etal., Clin Exp Rheumatol. 2009 Mar-Apr;27(2):229-36.
14. Profile of polymorphisms of drug-metabolising enzymes and the risk of therapy-related leukaemia. Bolufer P, etal., Br J Haematol. 2007 Feb;136(4):590-6.
15. Possible gene dosage effect of glutathione-S-transferases on atopic asthma: using real-time PCR for quantification of GSTM1 and GSTT1 gene copy numbers. Brasch-Andersen C, etal., Hum Mutat. 2004 Sep;24(3):208-14.
16. Association study of multiple gene polymorphisms with the risk of adult-onset primary open-angle glaucoma in a Mexican population. Buentello-Volante B, etal., Exp Eye Res. 2013 Feb;107:59-64. doi: 10.1016/j.exer.2012.11.013. Epub 2012 Nov 30.
17. Glutathione S-transferases M1-1 and T1-1 as risk modifiers for renal cell cancer associated with occupational exposure to chemicals. Buzio L, etal., Occup Environ Med. 2003 Oct;60(10):789-93.
18. Glutathione S-transferases M1, T1 genotypes and the risk of gastric cancer: a case-control study. Cai L, etal., World J Gastroenterol. 2001 Aug;7(4):506-9. doi: 10.3748/wjg.v7.i4.506.
19. The influence of genetic variation in oxidative stress genes on human noise susceptibility. Carlsson PI, etal., Hear Res. 2005 Apr;202(1-2):87-96.
20. Genetic polymorphisms of microsomal epoxide hydroxylase and glutathione S-transferases M1, T1 and P1, interactions with smoking, and risk for esophageal (Barrett) adenocarcinoma. Casson AG, etal., Cancer Detect Prev. 2006;30(5):423-31. Epub 2006 Oct 24.
1 to 20 of 168 rows
PMID:1848757   PMID:8670055   PMID:8761485   PMID:8799324   PMID:9307035   PMID:9434735   PMID:9854036   PMID:12038961   PMID:12477932   PMID:15489334   PMID:16496253   PMID:17827337  
PMID:23376485   PMID:23533145   PMID:33484035  



Gstt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,856,068 - 12,873,020 (+)NCBIGRCr8
mRatBN7.22012,856,613 - 12,873,586 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,856,669 - 12,873,585 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,563,264 - 13,580,163 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,924,193 - 12,941,104 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,396,180 - 13,413,203 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,799,102 - 13,816,527 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,799,102 - 13,816,526 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,989,083 - 16,006,508 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,604,355 - 13,621,456 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,604,582 - 13,621,683 (-)NCBI
Celera2014,348,088 - 14,365,283 (+)NCBICelera
Cytogenetic Map20p12NCBI
GSTT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh372224,376,133 - 24,384,311 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,706,141 - 22,714,231 (-)NCBINCBI36Build 36hg18NCBI36
Build 342222,700,694 - 22,708,785NCBI
Celera228,176,027 - 8,184,162 (-)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,324,342 - 7,332,477 (-)NCBIHuRef
T2T-CHM13v2.02224,441,300 - 24,449,468 (-)NCBIT2T-CHM13v2.0
Gstt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,619,647 - 75,634,418 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,619,647 - 75,634,418 (-)EnsemblGRCm39 Ensembl
GRCm381075,783,813 - 75,798,584 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,783,813 - 75,798,584 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,246,558 - 75,261,329 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,227,531 - 75,242,300 (-)NCBIMGSCv36mm8
Celera1076,828,580 - 76,843,364 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.58NCBI

.

.
Variants in Gstt1
84 total Variants

Predicted Target Of
Summary Value
Count of predictions:149
Count of miRNA genes:114
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000001669
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat

1 to 10 of 26 rows
RH130749  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,873,378 - 12,873,564 (+)MAPPERmRatBN7.2
Rnor_6.02013,816,320 - 13,816,505NCBIRnor6.0
Rnor_5.02016,006,301 - 16,006,486UniSTSRnor5.0
RGSC_v3.42013,604,377 - 13,604,562UniSTSRGSC3.4
Celera2014,365,076 - 14,365,261UniSTS
RH 3.4 Map20154.86UniSTS
Cytogenetic Map20p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001669   ⟹   ENSRNOP00000001669
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,856,669 - 12,873,580 (+)Ensembl
Rnor_6.0 Ensembl2013,799,102 - 13,816,526 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097156   ⟹   ENSRNOP00000090349
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,858,242 - 12,873,585 (+)Ensembl
RefSeq Acc Id: NM_053293   ⟹   NP_445745
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,856,117 - 12,873,020 (+)NCBI
mRatBN7.22012,856,680 - 12,873,586 (+)NCBI
Rnor_6.02013,799,102 - 13,816,527 (+)NCBI
Rnor_5.02015,989,083 - 16,006,508 (+)NCBI
RGSC_v3.42013,604,355 - 13,621,456 (-)RGD
Celera2014,348,088 - 14,365,283 (+)RGD
Sequence:
RefSeq Acc Id: XM_008772859   ⟹   XP_008771081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,856,399 - 12,873,014 (+)NCBI
mRatBN7.22012,856,930 - 12,873,580 (+)NCBI
Rnor_6.02013,799,394 - 13,816,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772860   ⟹   XP_008771082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,856,399 - 12,873,014 (+)NCBI
mRatBN7.22012,856,963 - 12,873,580 (+)NCBI
Rnor_6.02013,799,399 - 13,816,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008772861   ⟹   XP_008771083
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,870,182 - 12,873,014 (+)NCBI
mRatBN7.22012,870,795 - 12,873,580 (+)NCBI
Rnor_6.02013,813,552 - 13,816,521 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039098441   ⟹   XP_038954369
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,856,095 - 12,873,014 (+)NCBI
mRatBN7.22012,856,678 - 12,873,580 (+)NCBI
RefSeq Acc Id: XM_039098442   ⟹   XP_038954370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,856,068 - 12,873,014 (+)NCBI
mRatBN7.22012,856,613 - 12,871,278 (+)NCBI
RefSeq Acc Id: NP_445745   ⟸   NM_053293
- UniProtKB: Q01579 (UniProtKB/Swiss-Prot),   B6DYQ8 (UniProtKB/TrEMBL),   A0A8I6ADD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771082   ⟸   XM_008772860
- Peptide Label: isoform X3
- UniProtKB: A6JKH2 (UniProtKB/TrEMBL),   A0A8I6ADD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771081   ⟸   XM_008772859
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ADD6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008771083   ⟸   XM_008772861
- Peptide Label: isoform X5
- Sequence:
Ensembl Acc Id: ENSRNOP00000001669   ⟸   ENSRNOT00000001669
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-Q01579-F1-model_v2 AlphaFold Q01579 1-240 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701534
Promoter ID:EPDNEW_R12058
Type:multiple initiation site
Name:Gstt1_1
Description:glutathione S-transferase theta 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,799,083 - 13,799,143EPDNEW


1 to 38 of 38 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-4159 BioCyc
Ensembl Genes ENSRNOG00000049771 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001669 ENTREZGENE
  ENSRNOT00000001669.5 UniProtKB/Swiss-Prot
  ENSRNOT00000127679 ENTREZGENE
  ENSRNOT00000167270 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7301492 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_C_Theta UniProtKB/Swiss-Prot
  GST_N_Theta UniProtKB/Swiss-Prot
  GST_Theta UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:25260 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105379 IMAGE-MGC_LOAD
NCBI Gene 25260 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE THETA-1 UniProtKB/Swiss-Prot
  PTHR43917 UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PharmGKB GSTT1 RGD
PhenoGen Gstt1 PhenoGen
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000049771 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
TIGR TC206835
UniProt A0A8I6ADD6 ENTREZGENE, UniProtKB/TrEMBL
  A6JKH2 ENTREZGENE, UniProtKB/TrEMBL
  B6DYQ8 ENTREZGENE, UniProtKB/TrEMBL
  GSTT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q2XTA7_RAT UniProtKB/TrEMBL
1 to 38 of 38 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Gstt1  glutathione S-transferase theta 1    glutathione S-transferase, theta 1  Name updated 1299863 APPROVED
2002-06-10 Gstt1  Glutathione S-transferase 1 (theta)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_protein 244 amino acid residues 68795
gene_transcript transcript promoter region lacks both TATA and CAAT boxes 68795