Gstp1 (glutathione S-transferase pi 1) - Rat Genome Database

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Gene: Gstp1 (glutathione S-transferase pi 1) Rattus norvegicus
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Symbol: Gstp1
Name: glutathione S-transferase pi 1
RGD ID: 2758
Description: Enables protein kinase binding activity and toxic substance binding activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to epidermal growth factor stimulus; and negative regulation of smooth muscle cell chemotaxis. Predicted to be located in mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Biomarker of cholestasis; pre-malignant neoplasm; prostate carcinoma in situ; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1); PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; glutathione metabolic pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (E)-4-hydroxynon-2-enal; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chain 7; glutathione S-transferase P; glutathione S-transferase pi 2; glutathione S-transferase, pi 2; Glutathione-S-transferase placental enzyme pi type; glutathione-S-transferase, pi 1; Glutathione-S-transferase, placental enzyme pi type; GST 7-7; GST class-pi; GST-P; Gst3; Gstp; Gstp2; MGC72668; MGC72669
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Hcar4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,767,237 - 210,770,242 (-)NCBIGRCr8
mRatBN7.21201,337,762 - 201,340,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,321,672 - 201,340,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,690,040 - 209,692,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,783,226 - 216,785,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,474,253 - 209,476,723 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,291,679 - 219,294,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,291,679 - 219,294,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,162,330 - 226,164,798 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,627,398 - 206,629,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,780,853 - 206,783,288 (-)NCBI
Celera1198,882,807 - 198,885,275 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Gstp1Ratacute kidney failure  ISOGSTP1 (Homo sapiens)6903954 RGD 
Gstp1Ratacute lymphoblastic leukemia susceptibilityISOGSTP1 (Homo sapiens)10755321DNA:transition mutation:exon:RGD 
Gstp1Ratacute lymphoblastic leukemia no_associationISOGSTP1 (Homo sapiens)10755417DNA:polymorphism: :1578 a>G(human)RGD 
Gstp1Ratacute lymphoblastic leukemia disease_progressionISOGSTP1 (Homo sapiens)10450829DNA:haplotype:cds:RGD 
Gstp1Ratacute myeloid leukemia susceptibilityISOGSTP1 (Homo sapiens)10755328 RGD 
Gstp1Ratacute myeloid leukemia susceptibilityISOGSTP1 (Homo sapiens)10755420chemotherapy-inducedRGD 
Gstp1Ratacute myeloid leukemia susceptibilityISOGSTP1 (Homo sapiens)10755422DNA:polymorphism:cds:p.I105V(human)RGD 
Gstp1RatAirway Obstruction severityISOGSTP1 (Homo sapiens)4142525associated with Bronchial Hyperreactivity and DNA:polymorphism:exon:p.I105V (rs1695) (human)RGD 
Gstp1Ratalcohol use disorder  ISOGSTP1 (Homo sapiens)597621684DNA:SNP:: rs1695(human)RGD 
Gstp1Ratallergic disease susceptibilityISOGSTP1 (Homo sapiens)5133266DNA:polymorphism:exon:p.I105V (rs1695) (human)RGD 
Gstp1RatAlzheimer's disease onsetISOGSTP1 (Homo sapiens)5490271DNA:polymorphism:exon:RGD 
Gstp1RatAlzheimer's disease  ISOGstp1 (Mus musculus)10401913mRNA:decreased expression:cerebral cortexRGD 
Gstp1RatAlzheimer's disease  ISOGSTP1 (Homo sapiens)10401912DNA:polymorphismsRGD 
Gstp1RatAlzheimer's disease susceptibilityISOGSTP1 (Homo sapiens)5490123 RGD 
Gstp1Ratasthma  ISOGSTP1 (Homo sapiens)5490985DNA:SNPs: :p.I105V and p.A114V (human)RGD 
Gstp1Ratasthma  ISOGSTP1 (Homo sapiens)5490999DNA:SNPs:exons:p.I105V (rs1695), A114V (rs1138272) (human)RGD 
Gstp1Ratasthma no_associationISOGSTP1 (Homo sapiens)4142519DNA:SNPs: :p.I105V and p.A114V (human)RGD 
Gstp1Ratasthma disease_progressionISOGSTP1 (Homo sapiens)4140951DNA:polymorphism:exon:p.I105V (human)RGD 
Gstp1Ratasthma severityISOGstp1 (Mus musculus)4140946 RGD 
Gstp1Ratasthma  ISOGSTP1 (Homo sapiens)4140947DNA:SNP: :p.A114V (human)RGD 
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Gstp1RatAicardi-Goutieres Syndrome 3  ISOGSTP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Aicardi-Goutieres syndrome 3ClinVarPMID:28492532
Gstp1Ratchronic obstructive pulmonary disease  ISOGSTP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Pulmonary disease more ...ClinVarPMID:25741868
Gstp1Ratimmune system disease  ISOGSTP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Abnormality of immune system physiologyClinVarPMID:25741868
Gstp1Ratimmunodeficiency 90  ISOGSTP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Infections more ...ClinVarPMID:28492532
Gstp1Ratintellectual disability  ISOGSTP1 (Homo sapiens)8554872ClinVar Annotator: match by term: Intellectual disabilityClinVar 
1 to 20 of 44 rows
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Gstp1RatAcute Coronary Syndrome  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21751358
Gstp1Ratacute kidney failure  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750
Gstp1Ratamphetamine abuse  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15729709
Gstp1Ratamyotrophic lateral sclerosis  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16109392
Gstp1Ratasthma  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11994713 more ...
Gstp1Ratautism spectrum disorder  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Gstp1Ratautistic disorder  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17404132
Gstp1RatBreast Neoplasms  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25322848
Gstp1Ratcarcinoma  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11196146
Gstp1Ratcarotid artery disease  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16973168
Gstp1RatChemical and Drug Induced Liver Injury  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750 and PMID:25226513
Gstp1RatChromosome Aberrations  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16537716
Gstp1Ratchronic myeloid leukemia  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20843134
Gstp1Ratcontact dermatitis  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:25724174
Gstp1RatDisease Progression  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21364753
Gstp1Ratdrug allergy  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20485159
Gstp1Ratessential tremor  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:18215156
Gstp1RatExperimental Liver Neoplasms  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:2563599 more ...
Gstp1Rathepatocellular carcinoma  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:9029167
Gstp1Rathigh grade glioma  ISOGSTP1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16899598
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Gstp1Ratcystic fibrosis  ISOGSTP1 (Homo sapiens)1331525 GAD 

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Gstp1Rat(+)-artemisinin decreases activityISOGSTP1 (Homo sapiens)6480464artemisinin results in decreased activity of GSTP1 proteinCTDPMID:11807801
Gstp1Rat(-)-epigallocatechin 3-gallate decreases expressionISOGSTP1 (Homo sapiens)6480464epigallocatechin gallate results in decreased expression of GSTP1 mRNACTDPMID:18851785
Gstp1Rat(3,4-dihydroxyphenyl)acetic acid increases expressionEXP 64804643 and 4-Dihydroxyphenylacetic Acid results in increased expression of GSTP1 mRNACTDPMID:19743802
Gstp1Rat(E)-4-hydroxynon-2-enal affects bindingEXP 1641942(E)-4-hydroxynon-2-enal binds to Gstp1 protein RGD 
Gstp1Rat(R)-lipoic acid increases expressionEXP 6480464Thioctic Acid results in increased expression of GSTP1 mRNACTDPMID:20237067
Gstp1Rat(R)-lipoic acid multiple interactionsEXP 6480464[Thioctic Acid promotes the reaction [JUN protein binds to GSTP1 enhancer]] which results in increased expression of GSTP1 mRNA more ...CTDPMID:20237067
Gstp1Rat(RS)-goitrin multiple interactionsEXP 6480464Triiodothyronine inhibits the reaction [goitrin results in increased expression of GSTP1 protein]CTDPMID:7532609
Gstp1Rat(RS)-goitrin decreases expressionEXP 6480464goitrin results in decreased expression of GSTP1 proteinCTDPMID:7532609
Gstp1Rat(RS)-goitrin increases expressionEXP 6480464goitrin results in increased expression of GSTP1 proteinCTDPMID:7532609
Gstp1Rat1,2-Dibromo-3-chloropropane affects metabolic processingISOGSTP1 (Homo sapiens)6480464GSTP1 protein affects the metabolism of 1 and 2-dibromo-3-chloropropaneCTDPMID:8242859
Gstp1Rat1,2-Dibromo-3-chloropropane increases response to substanceISOGSTP1 (Homo sapiens)6480464GSTP1 protein results in increased susceptibility to 1 and 2-dibromo-3-chloropropaneCTDPMID:8242859
Gstp1Rat1,2-dichlorobenzene affects localizationISOGSTP1 (Homo sapiens)64804642-dichlorobenzene affects the localization of GSTP1 proteinCTDPMID:18409811
Gstp1Rat1,2-dichlorobenzene decreases activityISOGSTP1 (Homo sapiens)64804642-dichlorobenzene results in decreased activity of GSTP1 proteinCTDPMID:18409811
Gstp1Rat1,2-dichloroethane decreases expressionISOGstp1 (Mus musculus)6480464ethylene dichloride results in decreased expression of GSTP1 mRNACTDPMID:28189721 and PMID:28960355
Gstp1Rat1,2-dimethylhydrazine multiple interactionsISOGstp1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GSTP1 mRNACTDPMID:22206623
Gstp1Rat1,3-dichloropropan-2-ol increases expressionEXP 64804641 more ...CTDPMID:34269859
Gstp1Rat1,3-dinitrobenzene increases expressionEXP 64804643-dinitrobenzene results in increased expression of GSTP1 mRNACTDPMID:21983209
Gstp1Rat1,4-dioxane increases expressionISOGstp1 (Mus musculus)64804641 and 4-dioxane results in increased expression of GSTP1 mRNACTDPMID:33693819
Gstp1Rat1,4-phenylenediamine increases metabolic processingISOGSTP1 (Homo sapiens)64804644-phenylenediamine results in increased metabolism of GSTP1 proteinCTDPMID:19469519
Gstp1Rat1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole multiple interactionsISOGSTP1 (Homo sapiens)6480464sulconazole inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2 and 4-dinitrobenzene-glutathione conjugate]CTDPMID:23769903

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Biological Process
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Original Reference(s)
Gstp1Ratanimal organ regeneration  IEP 2317839 RGD 
Gstp1Ratcellular oxidant detoxification involved_inIEAGO:00046021600115GO_REF:0000108GOCGO_REF:0000108
Gstp1Ratcellular response to cell-matrix adhesion  IEP 2317832 RGD 
Gstp1Ratcellular response to epidermal growth factor stimulus  IEP 2317845 RGD 
Gstp1Ratcellular response to glucocorticoid stimulus  IEP 2317830 RGD 
Gstp1Ratcellular response to insulin stimulus  IEP 2317845 RGD 
Gstp1Ratcellular response to lipopolysaccharide involved_inISOGstp1 (Mus musculus)1624291 PMID:16023107RGDPMID:16023107
Gstp1Ratcellular response to lipopolysaccharide involved_inISSUniProtKB:P191571600115GO_REF:0000024BHF-UCLGO_REF:0000024
Gstp1Ratcommon myeloid progenitor cell proliferation involved_inISSUniProtKB:P191571600115GO_REF:0000024BHF-UCLGO_REF:0000024
Gstp1Ratcommon myeloid progenitor cell proliferation involved_inISOGstp1 (Mus musculus)1624291 PMID:11408560RGDPMID:11408560
Gstp1Ratglutathione derivative biosynthetic process involved_inISSUniProtKB:P092111600115GO_REF:0000024UniProtGO_REF:0000024
Gstp1Ratglutathione derivative biosynthetic process involved_inIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratglutathione derivative biosynthetic process involved_inISOGSTP1 (Homo sapiens)1624291 PMID:9084911RGDPMID:9084911
Gstp1Ratglutathione metabolic process involved_inISOGSTP1 (Homo sapiens)1624291 PMID:1540159RGDPMID:1540159
Gstp1Ratglutathione metabolic process involved_inIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratglutathione metabolic process acts_upstream_of_or_withinISOGstp1 (Mus musculus)1624291 PMID:7982937RGDPMID:7982937
Gstp1Ratglutathione metabolic process involved_inIBAFB:FBgn0010226 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstp1Rathepoxilin biosynthetic process involved_inISSUniProtKB:P092111600115GO_REF:0000024UniProtGO_REF:0000024
Gstp1Rathepoxilin biosynthetic process involved_inIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Rathepoxilin biosynthetic process involved_inISOGSTP1 (Homo sapiens)1624291 PMID:21046276RGDPMID:21046276
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Cellular Component
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Original Reference(s)
Gstp1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gstp1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gstp1Ratcytosol located_inISOGstp1 (Mus musculus)1624291 PMID:15100242RGDPMID:15100242
Gstp1Ratcytosol located_inIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratcytosol located_inIEAUniProtKB:V9HWE9 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratcytosol located_inISOGSTP1 (Homo sapiens)1624291 RGDGO_REF:0000052
Gstp1Ratcytosol is_active_inIBAMGI:95864 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstp1Ratmitochondrion located_inIEAUniProtKB:V9HWE9 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratmitochondrion located_inIEAUniProtKB-KW:KW-04961600115GO_REF:0000043UniProtGO_REF:0000043
Gstp1Ratmitochondrion located_inIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratmitochondrion located_inISOGSTP1 (Homo sapiens)1624291 RGDGO_REF:0000052
Gstp1Ratmitochondrion located_inIEAUniProtKB-SubCell:SL-01731600115GO_REF:0000044UniProtGO_REF:0000044
Gstp1Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Gstp1Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Gstp1Ratprotein-containing complex part_ofISSUniProtKB:P191571600115GO_REF:0000024BHF-UCLGO_REF:0000024
Gstp1Ratprotein-containing complex part_ofISOGstp1 (Mus musculus)1624291 PMID:11279197RGDPMID:11279197
Gstp1RatTRAF2-GSTP1 complex part_ofISOGSTP1 (Homo sapiens)1624291 PMID:16636664RGDPMID:16636664
Gstp1RatTRAF2-GSTP1 complex part_ofIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function
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Gstp1Ratdinitrosyl-iron complex binding enablesISOGSTP1 (Homo sapiens)1624291 PMID:11533048 and PMID:12871945RGDPMID:11533048 and PMID:12871945
Gstp1Ratdinitrosyl-iron complex binding enablesIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratfatty acid binding enablesISOGSTP1 (Homo sapiens)1624291CHEBI:72639 PMID:16624487RGDPMID:16624487
Gstp1Ratfatty acid binding enablesIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratglutathione peroxidase activity enablesISOGSTP1 (Homo sapiens)1624291 PMID:16624487RGDPMID:16624487
Gstp1Ratglutathione peroxidase activity enablesIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1Ratglutathione transferase activity enablesISOGSTP1 (Homo sapiens)1624291 PMID:1540159 and PMID:9084911RGDPMID:1540159 and PMID:9084911
Gstp1Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gstp1Ratglutathione transferase activity enablesIEAInterPro:IPR0030821600115GO_REF:0000002InterProGO_REF:0000002
Gstp1Ratglutathione transferase activity enablesISOGstp1 (Mus musculus)1624291 PMID:7982937RGDPMID:7982937
Gstp1Ratglutathione transferase activity enablesIBAFB:FBgn0010226 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstp1Ratglutathione transferase activity enablesIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
Gstp1RatJUN kinase binding enablesISSUniProtKB:P191571600115GO_REF:0000024BHF-UCLGO_REF:0000024
Gstp1RatJUN kinase binding enablesISOGstp1 (Mus musculus)1624291UniProtKB:Q91Y86 and PMID:11279197RGDPMID:11279197
Gstp1Ratkinase regulator activity enablesISOGstp1 (Mus musculus)1624291 PMID:12646564RGDPMID:12646564
Gstp1Ratprotein binding enablesISOGSTP1 (Homo sapiens)1624291UniProtKB:A8MQ03 more ...RGDPMID:16636664 more ...
Gstp1Ratprotein kinase binding  IPIPrkab2 (Rattus norvegicus)10401936 RGD 
Gstp1Ratprotein serine/threonine kinase inhibitor activity enablesISSUniProtKB:P191571600115GO_REF:0000024BHF-UCLGO_REF:0000024
Gstp1RatS-nitrosoglutathione binding enablesISOGSTP1 (Homo sapiens)1624291 PMID:11533048RGDPMID:11533048
Gstp1RatS-nitrosoglutathione binding enablesIEAUniProtKB:P09211 and ensembl:ENSP000003816071600115GO_REF:0000107EnsemblGO_REF:0000107
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RGD Manual Annotations


  
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Gstp1Ratglutathione conjugation pathway  IDA 1357965 RGD 
Gstp1Ratglutathione conjugation pathway  IDA 1641942 RGD 

Imported Annotations - SMPDB

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Gstp1Ratparacetamol pharmacokinetics pathway   ISOGSTP1 (Homo sapiens)10402751 SMPDBSMP:00640

Imported Annotations - KEGG (archival)

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Gstp1Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gstp1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gstp1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982
Gstp1Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215

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Reference Title
Reference Citation
1. Changes in tear protein profile in patients with conjunctivochalasis. Acera A, etal., Cornea. 2011 Jan;30(1):42-9. doi: 10.1097/ICO.0b013e3181dea7d7.
2. Glutathione S-transferase P1 Ile105Val polymorphism is associated with haematological toxicity in elderly rectal cancer patients receiving preoperative chemoradiotherapy. Agostini M, etal., Drugs Aging. 2008;25(6):531-9.
3. Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Allan JM, etal., Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11592-7. Epub 2001 Sep 11.
4. Effect of glutathione S-transferases on the survival of patients with acute myeloid leukaemia. Autrup JL, etal., Eur J Pharmacol. 2002 Mar 1;438(1-2):15-8.
5. Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier. Bauer B, etal., J Cereb Blood Flow Metab. 2008 Jun;28(6):1222-34. Epub 2008 Mar 19.
6. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele. Bernardini S, etal., Clin Chem. 2005 Jun;51(6):944-51. Epub 2005 Apr 1.
8. Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population. Bid HK, etal., J Postgrad Med. 2010 Jul-Sep;56(3):176-81.
9. Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study. Broberg K, etal., Environ Health. 2008 Apr 30;7:15.
10. Genetic polymorphisms associated with cigarette smoking and the risk of Graves' disease. Bufalo NE, etal., Clin Endocrinol (Oxf). 2008 Jun;68(6):982-7. Epub 2007 Nov 2.
11. Dietary chemoprevention of PhIP induced carcinogenesis in male Fischer 344 rats with tomato and broccoli. Canene-Adams K, etal., PLoS One. 2013 Nov 27;8(11):e79842. doi: 10.1371/journal.pone.0079842. eCollection 2013.
12. Maternal glutathione S-transferase GSTP1 genotype is a specific predictor of phenotype in children with asthma. Carroll WD, etal., Pediatr Allergy Immunol. 2005 Feb;16(1):32-9.
13. Polymorphisms of glutathione S-transferase genes and functional activity in smokers with or without COPD. Chan-Yeung M, etal., Int J Tuberc Lung Dis. 2007 May;11(5):508-14.
14. Proteomic profiling of brain cortex tissues in a Tau transgenic mouse model of Alzheimer's disease. Chang SH, etal., Biochem Biophys Res Commun. 2013 Jan 11;430(2):670-5. doi: 10.1016/j.bbrc.2012.11.093. Epub 2012 Dec 2.
15. GSTpi protects against angiotensin II-induced proliferation and migration of vascular smooth muscle cells by preventing signal transducer and activator of transcription 3 activation. Chen D, etal., Biochim Biophys Acta. 2014 Feb;1843(2):454-63. doi: 10.1016/j.bbamcr.2013.11.024. Epub 2013 Dec 7.
16. The enhancing effect of ethanol on the development of glutatione S-transferase placental form-positive foci induced by diethylnitrosamine in F344 rat. Cho KJ, etal., J Korean Med Sci. 1990 Mar;5(1):13-7.
17. Association of glutathione-S-transferase polymorphisms with atopic dermatitis risk in preschool age children. Chung J, etal., Clin Chem Lab Med. 2009;47(12):1475-81.
18. Polymorphism at the glutathione S-transferase P1 locus in Korean patients with perennial allergic rhinitis. Chung YS, etal., Am J Rhinol. 2006 Nov-Dec;20(6):648-51.
19. Tobacco and estrogen metabolic polymorphisms and risk of non-small cell lung cancer in women. Cote ML, etal., Carcinogenesis. 2009 Apr;30(4):626-35. Epub 2009 Jan 27.
20. Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Crawford EL, etal., Cancer Res. 2000 Mar 15;60(6):1609-18.
1 to 20 of 148 rows
PMID:1540159   PMID:3200831   PMID:3359441   PMID:3864155   PMID:7982937   PMID:9084911   PMID:10945608   PMID:11279197   PMID:11408560   PMID:11533048   PMID:12646564   PMID:12871945  
PMID:15489334   PMID:15809768   PMID:15863507   PMID:15867277   PMID:16023107   PMID:16242832   PMID:16407263   PMID:16624487   PMID:16636664   PMID:16728343   PMID:16728344   PMID:17596925  
PMID:17786572   PMID:18081878   PMID:19056867   PMID:19190083   PMID:20091025   PMID:20423715   PMID:20458337   PMID:21046276   PMID:22082260   PMID:22664934   PMID:23376485   PMID:23533145  
PMID:23580065   PMID:24412522   PMID:24474500   PMID:25164943   PMID:25419570   PMID:25974399   PMID:29501922   PMID:38959295  



Gstp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,767,237 - 210,770,242 (-)NCBIGRCr8
mRatBN7.21201,337,762 - 201,340,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,321,672 - 201,340,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,690,040 - 209,692,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,783,226 - 216,785,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,474,253 - 209,476,723 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,291,679 - 219,294,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,291,679 - 219,294,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,162,330 - 226,164,798 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,627,398 - 206,629,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,780,853 - 206,783,288 (-)NCBI
Celera1198,882,807 - 198,885,275 (-)NCBICelera
Cytogenetic Map1q43NCBI
GSTP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,583,812 - 67,586,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,583,742 - 67,586,656 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,351,283 - 67,354,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,107,862 - 67,110,699 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,107,861 - 67,110,699NCBI
Celera1164,685,527 - 64,688,585 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,680,236 - 63,683,230 (+)NCBIHuRef
CHM1_11167,234,118 - 67,237,177 (+)NCBICHM1_1
T2T-CHM13v2.01167,578,501 - 67,581,343 (+)NCBIT2T-CHM13v2.0
Gstp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,085,411 - 4,087,912 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,085,407 - 4,087,985 (-)EnsemblGRCm39 Ensembl
GRCm38194,035,411 - 4,037,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,035,407 - 4,037,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,035,411 - 4,037,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,035,411 - 4,037,912 (-)NCBIMGSCv36mm8
Celera193,906,327 - 3,908,828 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.75NCBI
Gstp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,914,305 - 17,917,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,914,228 - 17,916,918 (-)NCBIChiLan1.0ChiLan1.0
GSTP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,811,099 - 68,814,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,853,927 - 69,856,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,942,756 - 62,945,701 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,253,421 - 66,256,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,253,421 - 66,256,472 (+)Ensemblpanpan1.1panPan2
GSTP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,905,161 - 49,908,182 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,905,161 - 49,908,182 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,515,700 - 48,518,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,827,487 - 50,830,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,827,046 - 50,830,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,040,622 - 50,043,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,615,622 - 49,618,639 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,409,350 - 50,412,373 (-)NCBIUU_Cfam_GSD_1.0
Gstp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,755,332 - 5,758,293 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,197,634 - 2,201,050 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,197,681 - 2,200,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100739163
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.124,978,761 - 4,982,233 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,618,596 - 3,620,933 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,676,897 - 6,679,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038103,955,106 - 103,991,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Gstp1
11 total Variants

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:31
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000024601
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 80 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat

1 to 10 of 80 rows
D1Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,337,534 - 201,337,679 (+)MAPPERmRatBN7.2
Rnor_6.01219,291,452 - 219,291,596NCBIRnor6.0
Rnor_5.01226,162,103 - 226,162,247UniSTSRnor5.0
RGSC_v3.41206,627,170 - 206,627,315RGDRGSC3.4
RGSC_v3.41206,627,171 - 206,627,315UniSTSRGSC3.4
RGSC_v3.11206,780,623 - 206,780,768RGD
Celera1198,882,580 - 198,882,724UniSTS
RH 3.4 Map11559.1RGD
RH 3.4 Map11559.1UniSTS
Cytogenetic Map1q42UniSTS
RH137035  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81210,767,305 - 210,767,676 (+)Marker Load Pipeline
mRatBN7.21201,337,830 - 201,338,201 (+)MAPPERmRatBN7.2
Rnor_6.01219,291,748 - 219,292,118NCBIRnor6.0
Rnor_5.01226,162,399 - 226,162,769UniSTSRnor5.0
RGSC_v3.41206,627,467 - 206,627,837UniSTSRGSC3.4
Celera1198,882,876 - 198,883,246UniSTS
RH 3.4 Map11559.3UniSTS
Cytogenetic Map1q42UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000024601   ⟹   ENSRNOP00000024601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,321,672 - 201,340,226 (-)Ensembl
Rnor_6.0 Ensembl1219,291,679 - 219,294,147 (-)Ensembl
RefSeq Acc Id: NM_012577   ⟹   NP_036709
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,767,237 - 210,769,705 (-)NCBI
mRatBN7.21201,337,762 - 201,340,230 (-)NCBI
Rnor_6.01219,291,679 - 219,294,147 (-)NCBI
Rnor_5.01226,162,330 - 226,164,798 (-)NCBI
RGSC_v3.41206,627,398 - 206,629,866 (-)RGD
Celera1198,882,807 - 198,885,275 (-)RGD
Sequence:
RefSeq Acc Id: XM_063280727   ⟹   XP_063136797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,767,240 - 210,770,242 (-)NCBI
1 to 10 of 10 rows
Protein RefSeqs NP_036709 (Get FASTA)   NCBI Sequence Viewer  
  XP_063136797 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB59718 (Get FASTA)   NCBI Sequence Viewer  
  AAH58439 (Get FASTA)   NCBI Sequence Viewer  
  AAH58440 (Get FASTA)   NCBI Sequence Viewer  
  ACI32124 (Get FASTA)   NCBI Sequence Viewer  
  EDM12345 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000024601
  ENSRNOP00000024601.4
GenBank Protein P04906 (Get FASTA)   NCBI Sequence Viewer  
1 to 10 of 10 rows
RefSeq Acc Id: NP_036709   ⟸   NM_012577
- UniProtKB: P04906 (UniProtKB/Swiss-Prot),   B6DYQ7 (UniProtKB/TrEMBL),   A6HYR6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000024601   ⟸   ENSRNOT00000024601
RefSeq Acc Id: XP_063136797   ⟸   XM_063280727
- Peptide Label: isoform X1
- UniProtKB: P04906 (UniProtKB/Swiss-Prot),   B6DYQ7 (UniProtKB/TrEMBL),   A6HYR6 (UniProtKB/TrEMBL)
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P04906-F1-model_v2 AlphaFold P04906 1-210 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690608
Promoter ID:EPDNEW_R1133
Type:multiple initiation site
Name:Gstp1_1
Description:glutathione S-transferase pi 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01219,294,147 - 219,294,207EPDNEW


1 to 39 of 39 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-56782 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000018237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024601 ENTREZGENE
  ENSRNOT00000024601.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6889675 IMAGE-MGC_LOAD
  IMAGE:6917961 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_pi UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:24426 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72668 IMAGE-MGC_LOAD
  MGC:72669 IMAGE-MGC_LOAD
NCBI Gene 24426 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE P UniProtKB/Swiss-Prot
Pfam GST_C_3 UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PharmGKB GSTP1 RGD
PhenoGen Gstp1 PhenoGen
PRINTS GSTRNSFRASEP UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018237 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
TIGR TC217242
UniProt A6HYR6 ENTREZGENE, UniProtKB/TrEMBL
  B6DYQ7 ENTREZGENE, UniProtKB/TrEMBL
  GSTP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 39 of 39 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-06 Gstp1  glutathione S-transferase pi 1  Gstp1  glutathione-S-transferase, pi 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Gstp1  glutathione-S-transferase, pi 1  Gstp2  glutathione S-transferase, pi 2  Data merged from RGD:1598665 737654 APPROVED
2006-12-10 Gstp2  glutathione S-transferase, pi 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-03-17 Gstp1  glutathione-S-transferase, pi 1  Gstp2  glutathione S-transferase, pi 2  Data merged from RGD:68421 737654 APPROVED
2003-04-09 Gstp1  Glutathione-S-transferase, placental enzyme pi 1  Gstp  Glutathione-S-transferase, placental enzyme pi type  Name updated 629478 APPROVED
2002-06-10 Gstp  Glutathione-S-transferase, placental enzyme pi type      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Gstp2  glutathione S-transferase, pi 2      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in liver and fibroblast cells 70479
gene_expression may be induced in response to certain types of liver damages 70249
gene_process conjugates glutathione with acceptor molecules 70479
gene_process functions in converting fat soluble chemicals to water-soluble to inhibit build-up of hydrophobic compounds in adipose 70479