Gstp1 (glutathione S-transferase pi 1) - Rat Genome Database

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Gene: Gstp1 (glutathione S-transferase pi 1) Rattus norvegicus
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Symbol: Gstp1
Name: glutathione S-transferase pi 1
RGD ID: 2758
Description: Enables organic cyclic compound binding activity; protein kinase binding activity; and toxic substance binding activity. Involved in several processes, including cellular response to cell-matrix adhesion; cellular response to epidermal growth factor stimulus; and cellular response to hormone stimulus. Predicted to be located in mitochondrion. Predicted to be part of TRAF2-GSTP1 complex. Predicted to be active in cytosol. Biomarker of cholestasis; pre-malignant neoplasm; prostate carcinoma in situ; prostatic hypertrophy; and urinary bladder cancer. Human ortholog(s) of this gene implicated in several diseases, including allergic disease (multiple); carcinoma (multiple); hematologic cancer (multiple); reproductive organ cancer (multiple); and respiratory system disease (multiple). Orthologous to human GSTP1 (glutathione S-transferase pi 1); PARTICIPATES IN glutathione conjugation pathway; paracetamol pharmacokinetics pathway; glutathione metabolic pathway; INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (E)-4-hydroxynon-2-enal; (R)-lipoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: chain 7; glutathione S-transferase P; glutathione S-transferase pi 2; glutathione S-transferase, pi 2; Glutathione-S-transferase placental enzyme pi type; glutathione-S-transferase, pi 1; Glutathione-S-transferase, placental enzyme pi type; GST 7-7; GST class-pi; GST-P; Gst3; Gstp; Gstp2; MGC72668; MGC72669
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Candidate Gene For: Hcar4
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,767,237 - 210,770,242 (-)NCBIGRCr8
mRatBN7.21201,337,762 - 201,340,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,321,672 - 201,340,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,690,040 - 209,692,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,783,226 - 216,785,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,474,253 - 209,476,723 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,291,679 - 219,294,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,291,679 - 219,294,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,162,330 - 226,164,798 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,627,398 - 206,629,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,780,853 - 206,783,288 (-)NCBI
Celera1198,882,807 - 198,885,275 (-)NCBICelera
Cytogenetic Map1q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Acute Coronary Syndrome  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute myeloid leukemia  (ISO)
Aicardi-Goutieres Syndrome 3  (ISO)
Airway Obstruction  (ISO)
allergic disease  (ISO)
Alzheimer's disease  (ISO)
amphetamine abuse  (ISO)
amyotrophic lateral sclerosis  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
bone marrow disease  (ISO)
breast cancer  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
bronchopulmonary dysplasia  (ISO)
bronchus carcinoma  (ISO)
carcinoma  (ISO)
carotid artery disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholangiocarcinoma  (ISO)
Cholangiofibrosis  (IEP)
cholestasis  (IEP)
Chromosome Aberrations  (ISO)
Chronic Cerebral Hypoperfusion  (IDA)
chronic myeloid leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell renal cell carcinoma  (ISO)
colorectal adenoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
conjunctivochalasis  (ISO)
contact dermatitis  (ISO)
Cough  (ISO)
cystic fibrosis  (ISO)
diffuse large B-cell lymphoma  (ISO)
Disease Progression  (ISO)
drug allergy  (ISO)
Drug-Induced Leukopenia  (ISO)
Drug-induced Neutropenia  (ISO)
esophagus squamous cell carcinoma  (ISO)
essential tremor  (ISO)
Experimental Liver Neoplasms  (IEP,ISO)
Experimental Seizures  (IEP)
Focal Nodular Hyperplasia  (IEP)
Gallbladder Neoplasms  (ISO)
genetic disease  (ISO)
Graves' disease  (ISO)
hematopoietic system disease  (ISO)
hepatocellular carcinoma  (ISO)
high grade glioma  (ISO)
Hodgkin's lymphoma  (ISO)
hypertension  (ISO)
intellectual disability  (ISO)
Kidney Calculi  (ISO)
kidney disease  (ISO)
Kuhnt-Junius degeneration  (ISO)
Laryngeal Neoplasms  (ISO)
late onset Parkinson's disease  (ISO)
liver disease  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
lymphoid leukemia  (ISO)
malignant astrocytoma  (ISO)
melanoma  (ISO)
meningitis  (ISO)
metabolic dysfunction-associated steatotic liver disease  (ISO)
mitochondrial metabolism disease  (ISO)
movement disease  (ISO)
multiple myeloma  (ISO)
multiple sclerosis  (ISO)
myelodysplastic syndrome  (ISO)
myeloid leukemia  (ISO)
Myocardial Ischemia  (ISO)
Necrosis  (ISO)
oral squamous cell carcinoma  (ISO)
osteoporosis  (ISO)
osteosarcoma  (ISO)
ovarian cancer  (ISO)
pancreatic cancer  (ISO)
pancreatic ductal carcinoma  (ISO)
Parkinson's disease  (ISO)
Perennial Allergic Rhinitis  (ISO)
peripheral nervous system disease  (ISO)
peritonitis  (ISO)
Plasmodium falciparum malaria  (ISO)
pre-eclampsia  (ISO)
pre-malignant neoplasm  (IEP,ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (IEP,ISO)
prostatic hypertrophy  (IEP)
Prostatic Neoplasms  (ISO)
Pseudomonas Infections  (ISO)
psoriasis  (ISO)
pulmonary emphysema  (ISO)
pulmonary fibrosis  (ISO)
Recurrent Infections, with Encephalopathy, Hepatic Dysfunction, and Cardiovascular Malformations  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (ISO)
Respiratory Sounds  (ISO)
respiratory system disease  (ISO)
sarcoma  (ISO)
senile cataract  (ISO)
squamous cell carcinoma  (ISO)
Stomach Neoplasms  (ISO)
substance-induced psychosis  (ISO)
testicular cancer  (ISO)
toxic encephalopathy  (ISO)
type 2 diabetes mellitus  (ISO)
Ureteral Calculi  (ISO)
urinary bladder cancer  (IEP,ISO)
vestibular disease  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(E)-4-hydroxynon-2-enal  (EXP)
(R)-lipoic acid  (EXP)
(RS)-goitrin  (EXP)
1,2-Dibromo-3-chloropropane  (ISO)
1,2-dichlorobenzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dichloropropan-2-ol  (EXP)
1,3-dinitrobenzene  (EXP)
1,4-dioxane  (ISO)
1,4-phenylenediamine  (ISO)
1-\{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl\}-1H-imidazole  (ISO)
1-bromopropane  (EXP)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-Hydroxypyrene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,5-di-tert-butylbenzene-1,4-diol  (EXP)
2,5-hexanedione  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP,ISO)
2-acetamidofluorene  (EXP)
2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine  (ISO)
2-allylphenol  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (EXP)
2-amino-7-methyl-1,7-dihydro-6H-purin-6-one  (ISO)
2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one  (ISO)
2-hexenal  (ISO)
2-hydroxybenzoic acid (3,3,5-trimethylcyclohexyl) ester  (ISO)
2-methoxyethanol  (EXP)
2-nitrofluorene  (EXP)
2-phenylpropanal  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-methylcholanthrene  (EXP)
3-nitropropanoic acid  (EXP)
3-phenoxybenzoic acid  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4'-hydroxydiclofenac  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-Chloronitrobenzene  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-Propylphenol  (EXP,ISO)
4-vinylcyclohexene dioxide  (EXP)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-hydroxydiclofenac  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acetic acid  (ISO)
aclacinomycin A  (ISO)
acridine orange  (ISO)
acridine orange free base  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
actinomycin D  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B1 exo-8,9-epoxide  (EXP)
aldosterone  (EXP)
all-trans-retinoic acid  (EXP,ISO)
all-trans-retinol  (ISO)
allyl isothiocyanate  (ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-methyl-L-dopa  (ISO)
alpha-naphthoflavone  (ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
amphotericin B  (EXP,ISO)
angelica lactone  (ISO)
anthracene-1,8,9-triol  (ISO)
aristolochic acid A  (EXP,ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
artesunate  (ISO)
asbestos  (ISO)
atovaquone  (ISO)
ATP  (ISO)
atrazine  (EXP,ISO)
Aurothioglucose  (ISO)
avobenzone  (ISO)
Bardoxolone methyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[c]phenanthrene  (ISO)
BENZO[G]CHRYSENE  (ISO)
Benzo[k]fluoranthene  (ISO)
benzopyran  (EXP)
benzyl isothiocyanate  (EXP,ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (EXP,ISO)
betamethasone dipropionate  (ISO)
bifenthrin  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bromindione  (ISO)
Bucillamine  (ISO)
bufalin  (ISO)
buspirone  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (EXP,ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cafestol  (EXP)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
captafol  (ISO)
captan  (ISO)
carbamazepine-10,11-epoxide  (ISO)
carbon nanotube  (ISO)
carboplatin  (ISO)
carmustine  (ISO)
carnosic acid  (EXP,ISO)
cefaloridine  (EXP)
celecoxib  (ISO)
cerium trichloride  (ISO)
CHIR 99021  (ISO)
chlorambucil  (ISO)
chloramphenicol palmitate  (ISO)
chlorobenzene  (ISO)
chloroethene  (ISO)
chloropicrin  (ISO)
chlorotrianisene  (ISO)
chlortetracycline  (ISO)
chromium(6+)  (ISO)
cimetidine  (ISO)
cis-caffeic acid  (EXP)
cisplatin  (EXP,ISO)
Clasto-Lactacystin beta-lactone  (ISO)
clobetasol  (ISO)
clofazimine  (ISO)
clofibrate  (EXP,ISO)
clomipramine  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobamamide  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cortisol  (ISO)
coumarin  (EXP,ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (EXP,ISO)
crystal violet  (ISO)
cumene  (ISO)
cumene hydroperoxide  (ISO)
curcumin  (EXP,ISO)
cyclohexanols  (EXP)
cyclophosphamide  (EXP,ISO)
cycloprothrin  (ISO)
cypermethrin  (EXP)
dapsone  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dexamethasone  (EXP)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (EXP,ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dibenzofurans  (ISO)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dienestrol  (ISO)
diethyl maleate  (EXP)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
dihydrolipoic acid  (EXP)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP,ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
diquat  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxepin  (ISO)
doxorubicin  (EXP,ISO)
doxycycline  (ISO)
ebselen  (EXP)
econazole  (ISO)
elemental selenium  (EXP,ISO)
emodin  (ISO)
endosulfan  (EXP)
enoxacin  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP,ISO)
equilin  (ISO)
ergotamine  (ISO)
eriodictyol  (ISO)
erythrosin B  (ISO)
Estradiol 17beta-cyclopentylpropionate  (ISO)
etacrynic acid  (EXP,ISO)
ethanol  (EXP,ISO)
ethoxyquin  (EXP)
ethylbenzene  (ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
fenbendazole  (ISO)
fenofibrate  (ISO)
fenvalerate  (EXP)
fipronil  (EXP)
flavonoids  (ISO)
flufenamic acid  (ISO)
flunarizine  (ISO)
Fluocinonide  (ISO)
flurotyl  (ISO)
flutamide  (EXP,ISO)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (EXP,ISO)
FR900359  (ISO)
fumaraldehyde  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
galangin  (ISO)
gamma-glutamyl-glutathione  (EXP)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
glutathione  (EXP,ISO)
glycerol  (ISO)
haloperidol  (ISO)
hemin  (ISO)
heptan-2-one  (ISO)
herbicide  (ISO)
hexachlorobenzene  (EXP)
hexachlorophene  (ISO)
homocysteine  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyzine  (ISO)
hypericin  (EXP,ISO)
ifosfamide  (ISO)
imipramine  (ISO)
indirubin  (ISO)
indole-3-methanol  (EXP,ISO)
iodide salt  (EXP)
iodoquinol  (ISO)
iron dichloride  (ISO)
isomethyleugenol  (EXP,ISO)
isoniazide  (EXP)
isopimpinellin  (ISO)
isothiocyanate  (ISO)
isotretinoin  (ISO)
itraconazole  (ISO)
ivermectin  (ISO)
kaempferol  (ISO)
kahweol  (EXP)
ketoconazole  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-selenocysteine  (EXP)
lansoprazole  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
leflunomide  (EXP,ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
LY294002  (EXP,ISO)
malathion  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
mebendazole  (ISO)
Meclizine  (ISO)
mefenamic acid  (ISO)
MeIQx  (ISO)
melatonin  (EXP,ISO)
melphalan  (ISO)
merbromin  (ISO)
mercury atom  (EXP,ISO)
mercury dibromide  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
Mesna  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methyl 2-methylpropyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate  (ISO)
methylarsonic acid  (EXP)
methylene blue  (ISO)
methylmercury chloride  (ISO)
microcystin  (EXP)
microcystin RR  (ISO)
microcystin-LR  (ISO)
minocycline  (EXP)
mitomycin C  (ISO)
Mitotane  (ISO)
MK 571  (ISO)
monobromobimane  (ISO)
monocrotophos  (EXP,ISO)
monosodium L-glutamate  (ISO)
Muraglitazar  (EXP)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-1,4-benzoquinone imine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-hydroxy-PhIP  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
naphthalene  (ISO)
naringin  (EXP)
nefazodone  (EXP)
nevirapine  (ISO)
nicotinamide  (EXP)
nifedipine  (ISO)
nimesulide  (EXP)
nisoldipine  (ISO)
nitrendipine  (ISO)
nitrogen dioxide  (ISO)
O-acetyl-L-carnitine  (EXP)
O-methyleugenol  (EXP,ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
oltipraz  (EXP,ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
oxaliplatin  (ISO)
oxiconazole  (ISO)
oxidopamine  (EXP,ISO)
oxybenzone  (EXP)
oxyphenbutazone  (ISO)
ozone  (ISO)
p-toluidine  (EXP)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pararosaniline free base  (ISO)
parathion  (ISO)
pentachlorobenzene  (EXP)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenolphthalein  (ISO)
Phenoxybenzamine  (ISO)
phenylbutazone  (ISO)
phenylmercury acetate  (ISO)
PhIP  (EXP,ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
phosphoramide mustard  (EXP)
phylloquinone  (ISO)
pioglitazone  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
platinum  (ISO)
platinum(0)  (ISO)
plumbagin  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
propane-1,2-diol  (ISO)
Propiverine  (EXP)
Pyrantel pamoate  (ISO)
pyrazinecarboxamide  (EXP)
Pyridostigmine bromide  (EXP)
pyrimethamine  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quercitrin  (ISO)
quinidine  (ISO)
quinine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-hexylglutathione  (ISO)
salvianolic acid B  (ISO)
sanguinarine  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
soybean oil  (EXP)
stavudine  (EXP)
stilbene oxide  (EXP)
streptozocin  (EXP)
styrene  (ISO)
styrene oxide  (ISO)
Sudan I  (EXP)
sulconazole  (ISO)
sulfamethoxazole  (ISO)
sulfaphenazole  (ISO)
sulfasalazine  (EXP)
sulfinpyrazone  (ISO)
sulforaphane  (EXP,ISO)
sulfotep  (ISO)
sulfur dioxide  (ISO)
sulindac sulfide  (ISO)
sulindac sulfone  (ISO)
T-2 toxin  (EXP)
tamoxifen  (ISO)
Tanshinone I  (ISO)
tauroursodeoxycholic acid  (EXP)
temephos  (ISO)
temozolomide  (ISO)
teniposide  (ISO)
terbinafine  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
Testosterone propionate  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
thiophenes  (ISO)
thiostrepton  (ISO)
Thiotepa  (ISO)
Thonningianin A  (ISO)
thymoquinone  (EXP)
Tiopronin  (ISO)
titanium dioxide  (ISO)
tolnaftate  (ISO)
toluene  (EXP,ISO)
toluene 2,4-diisocyanate  (ISO)
tranilast  (ISO)
trans-caffeic acid  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
trimethylarsine oxide  (EXP)
triphenyl phosphate  (EXP)
Tris(1-aziridinyl)phosphine oxide  (ISO)
Tris(2,3-dibromopropyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
uranium atom  (EXP)
valproic acid  (ISO)
vincaleukoblastine  (EXP)
vinclozolin  (EXP)
vincristine  (ISO)
vitamin D  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
WR-1065  (ISO)
xanthohumol  (ISO)
XAV939  (ISO)
zearalenone  (ISO)
zerumbone  (ISO)
zinc dichloride  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEP)
cellular oxidant detoxification  (IEA)
cellular response to cell-matrix adhesion  (IEP)
cellular response to epidermal growth factor stimulus  (IEP)
cellular response to glucocorticoid stimulus  (IEP)
cellular response to insulin stimulus  (IEP)
cellular response to lipopolysaccharide  (ISO,ISS)
common myeloid progenitor cell proliferation  (ISO,ISS)
glutathione derivative biosynthetic process  (ISO,ISS)
glutathione metabolic process  (ISO)
hepoxilin biosynthetic process  (ISO,ISS)
linoleic acid metabolic process  (ISO)
negative regulation of biosynthetic process  (ISO)
negative regulation of canonical NF-kappaB signal transduction  (ISO,ISS)
negative regulation of ERK1 and ERK2 cascade  (ISO,ISS)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of fibroblast proliferation  (ISO,ISS)
negative regulation of interleukin-1 beta production  (ISO,ISS)
negative regulation of leukocyte proliferation  (ISO,ISS)
negative regulation of monocyte chemotactic protein-1 production  (ISO,ISS)
negative regulation of nitric-oxide synthase biosynthetic process  (ISO,ISS)
negative regulation of protein kinase activity  (IMP)
negative regulation of smooth muscle cell chemotaxis  (IMP)
negative regulation of stress-activated MAPK cascade  (ISO,ISS)
negative regulation of tumor necrosis factor production  (ISO,ISS)
negative regulation of vascular associated smooth muscle cell proliferation  (IMP)
oligodendrocyte development  (IEP)
positive regulation of superoxide anion generation  (ISO,ISS)
prostaglandin metabolic process  (ISO,ISS)
regulation of ERK1 and ERK2 cascade  (ISO,ISS)
regulation of stress-activated MAPK cascade  (ISO,ISS)
response to amino acid  (IEP)
response to estradiol  (IEP)
response to ethanol  (IEP)
response to L-ascorbic acid  (IEP)
response to nutrient levels  (IEP)
response to reactive oxygen species  (ISO,ISS)
response to toxic substance  (IEP)
xenobiotic metabolic process  (ISO,TAS)

Cellular Component

References

References - curated
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84. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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97. Proteomics profiling of nuclear proteins for kidney fibroblasts suggests hypoxia, meiosis, and cancer may meet in the nucleus. Shakib K, etal., Proteomics. 2005 Jul;5(11):2819-38.
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105. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
106. Changes in polypeptide pattern of rat liver cells during chemical hepatocarcinogenesis. Sugioka Y, etal., Cancer Res. 1985 Jan;45(1):365-78.
107. Pharmacogenetic association between GSTP1 genetic polymorphism and febrile neutropenia in Japanese patients with early breast cancer. Sugishita M, etal., Breast Cancer. 2014 Jul 10.
108. Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA. Suguoka Y, etal., Nucleic Acids Res 1985 Sep 11;13(17):6049-57.
109. Proteomic analysis of clear cell renal cell carcinoma. Identification of potential tumor markers. Sun CY, etal., Saudi Med J. 2010 May;31(5):525-32.
110. Glutathione-S-transferase P1 is a critical regulator of Cdk5 kinase activity. Sun KH, etal., J Neurochem. 2011 Sep;118(5):902-14. doi: 10.1111/j.1471-4159.2011.07343.x. Epub 2011 Jul 8.
111. Possible involvement of genotoxic mechanisms in estragole-induced hepatocarcinogenesis in rats. Suzuki Y, etal., Arch Toxicol. 2012 Oct;86(10):1593-601. doi: 10.1007/s00204-012-0865-8. Epub 2012 May 11.
112. Intracellular translocation of glutathione S-transferase pi during oligodendrocyte differentiation in adult rat cerebral cortex in vivo. Tamura Y, etal., Neuroscience. 2007 Aug 24;148(2):535-40. Epub 2007 Aug 2.
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114. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
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116. Increased expression of alpha-1-antitrypsin, glutathione S-transferase pi and vascular endothelial growth factor in human pancreatic adenocarcinoma. Trachte AL, etal., Am J Surg. 2002 Dec;184(6):642-7; discussion 647-8.
117. Characterization of glutathione S-transferases in rat kidney. Alteration of composition by cis-platinum. Trakshel GM and Maines MD, Biochem J. 1988 May 15;252(1):127-36.
118. Young patients with oral squamous cell carcinoma: study of the involvement of GSTP1 and deregulation of the Fanconi anemia genes. Tremblay S, etal., Arch Otolaryngol Head Neck Surg. 2006 Sep;132(9):958-66.
119. Methionine restriction up-regulates the expression of the pi class of glutathione S-transferase partially via the extracellular signal-regulated kinase-activator protein-1 signaling pathway initiated by glutathione depletion. Tsai CW, etal., Mol Nutr Food Res. 2009 Dec 10.
120. Pharmacogenetic influence of GST polymorphisms on anthracycline-based chemotherapy responses and toxicity in breast cancer patients: a multi-analytical approach. Tulsyan S, etal., Mol Diagn Ther. 2013 Dec;17(6):371-9. doi: 10.1007/s40291-013-0045-4.
121. Messenger RNA profiles in liver injury and stress: a comparison of lethal and nonlethal rat models. Tygstrup N, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):518-25.
122. Genetic polymorphisms of GSTP1 and mEPHX correlate with oxidative stress markers and lung function in COPD. Vibhuti A, etal., Biochem Biophys Res Commun. 2007 Jul 20;359(1):136-42. Epub 2007 May 22.
123. Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease. Vilar R, etal., Eur J Neurol. 2007 Feb;14(2):156-61.
124. The association between glutathione S-transferase gene polymorphisms and pancreatic cancer in a central European Slavonic population. Vrana D, etal., Mutat Res. 2009 Nov-Dec;680(1-2):78-81. Epub 2009 Sep 26.
125. Synergy among phytochemicals within crucifers: does it translate into chemoprotection? Wallig MA, etal., J Nutr. 2005 Dec;135(12 Suppl):2972S-2977S.
126. GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis. Wang IJ, etal., Ann Allergy Asthma Immunol. 2010 Aug;105(2):124-9. Epub 2010 Jun 11.
127. Effects of arsenic exposure and genetic polymorphisms of p53, glutathione S-transferase M1, T1, and P1 on the risk of carotid atherosclerosis in Taiwan. Wang YH, etal., Atherosclerosis. 2007 Jun;192(2):305-12. Epub 2006 Sep 14.
128. Cilostazol protects against brain white matter damage and cognitive impairment in a rat model of chronic cerebral hypoperfusion. Watanabe T, etal., Stroke. 2006 Jun;37(6):1539-45. Epub 2006 Apr 27.
129. In utero smoke exposure, glutathione S-transferase P1 haplotypes, and respiratory illness-related absence among schoolchildren. Wenten M, etal., Pediatrics. 2009 May;123(5):1344-51.
130. Association analysis of drug metabolizing enzyme gene polymorphisms in AIDS patients with cutaneous reactions to sulfonamides. Wolkenstein P, etal., J Invest Dermatol. 2005 Nov;125(5):1080-2.
131. Glutathione-S-transferase variants and adult glioma. Wrensch M, etal., Cancer Epidemiol Biomarkers Prev. 2004 Mar;13(3):461-7.
132. The presence and significance of the Pi class glutathione S-transferase isoenzyme in cerebrospinal fluid during the course of meningitis in children. Wylie-Modro S, etal., Pediatr Res. 1997 Aug;42(2):232-6.
133. [Relation of GSTP1 and CYP2E1 polymorphisms with susceptibility to acute leukemia]. Xi YM, etal., Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011 Jun;19(3):589-93.
134. Promoter methylation profiles of tumor suppressor genes in intrahepatic and extrahepatic cholangiocarcinoma. Yang B, etal., Mod Pathol. 2005 Mar;18(3):412-20.
135. Vascular tight junction disruption and angiogenesis in spontaneously hypertensive rat with neuroinflammatory white matter injury. Yang Y, etal., Neurobiol Dis. 2018 Jun;114:95-110. doi: 10.1016/j.nbd.2018.02.012. Epub 2018 Feb 24.
136. Association analysis of glutathione-S-transferase P1 (GSTP1) polymorphism with urothelial cancer susceptibility and myelosuppression after M-VAC chemotherapy. Yokomizo A, etal., Int J Urol. 2007 Jun;14(6):500-4.
137. Genetic determinants in the metabolism of bladder carcinogens in relation to risk of bladder cancer. Yuan JM, etal., Carcinogenesis. 2008 Jul;29(7):1386-93. Epub 2008 Jun 9.
138. Relationship between glutathione S-transferase M1, T1, and P1 polymorphisms and chronic lymphocytic leukemia. Yuille M, etal., Blood. 2002 Jun 1;99(11):4216-8.
139. Association of A(313)G glutathione S-transferase P1 germline polymorphism with susceptibility to de novo myelodysplastic syndrome. Zachaki S, etal., Leuk Lymphoma. 2013 Aug;54(8):1756-61. doi: 10.3109/10428194.2012.762647. Epub 2013 Jan 28.
140. Inhibition of urinary bladder carcinogenesis by aqueous extract of sclerotia of Polyporus umbellatus fries and polyporus polysaccharide. Zhang G, etal., Am J Chin Med. 2011;39(1):135-44.
141. Relationship of glutathione S-transferase genotypes with side-effects of pulsed cyclophosphamide therapy in patients with systemic lupus erythematosus. Zhong S, etal., Br J Clin Pharmacol. 2006 Oct;62(4):457-72.
142. Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma. Zhou J, etal., Am J Respir Crit Care Med. 2008 Dec 15;178(12):1202-10. Epub 2008 Sep 11.
143. [Identification of tumor-associated proteins in laryngeal squamous cell carcinoma by proteomics] Zhou JR, etal., Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2007 Dec;42(12):934-8.
144. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Zienolddiny S, etal., Carcinogenesis. 2008 Jun;29(6):1164-9. Epub 2008 Feb 6.
145. [Increased frequency of A-G transition at exon 5 of GSTP1 as a genetic risk factor for acute childhood leukaemia]. Zubowska M, etal., Med Wieku Rozwoj. 2004 Apr-Jun;8(2 Pt 1):245-57.
146. Paternal contribution to the risk for pre-eclampsia. Zusterzeel PL, etal., J Med Genet 2002 Jan;39(1):44-5.
Additional References at PubMed
PMID:1540159   PMID:3200831   PMID:3359441   PMID:3864155   PMID:7982937   PMID:9084911   PMID:10945608   PMID:11279197   PMID:11408560   PMID:11533048   PMID:12646564   PMID:12871945  
PMID:15489334   PMID:15809768   PMID:15863507   PMID:15867277   PMID:16023107   PMID:16242832   PMID:16407263   PMID:16624487   PMID:16636664   PMID:16728343   PMID:16728344   PMID:17596925  
PMID:17786572   PMID:18081878   PMID:19056867   PMID:19190083   PMID:20091025   PMID:20423715   PMID:20458337   PMID:21046276   PMID:22082260   PMID:22664934   PMID:23376485   PMID:23533145  
PMID:23580065   PMID:24412522   PMID:24474500   PMID:25164943   PMID:25419570   PMID:25974399   PMID:29501922  


Genomics

Comparative Map Data
Gstp1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81210,767,237 - 210,770,242 (-)NCBIGRCr8
mRatBN7.21201,337,762 - 201,340,230 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1201,321,672 - 201,340,226 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1209,690,040 - 209,692,503 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01216,783,226 - 216,785,696 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01209,474,253 - 209,476,723 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01219,291,679 - 219,294,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1219,291,679 - 219,294,147 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01226,162,330 - 226,164,798 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,627,398 - 206,629,866 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11206,780,853 - 206,783,288 (-)NCBI
Celera1198,882,807 - 198,885,275 (-)NCBICelera
Cytogenetic Map1q43NCBI
GSTP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381167,583,812 - 67,586,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1167,583,742 - 67,586,656 (+)EnsemblGRCh38hg38GRCh38
GRCh371167,351,283 - 67,354,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,107,862 - 67,110,699 (+)NCBINCBI36Build 36hg18NCBI36
Build 341167,107,861 - 67,110,699NCBI
Celera1164,685,527 - 64,688,585 (+)NCBICelera
Cytogenetic Map11q13.2NCBI
HuRef1163,680,236 - 63,683,230 (+)NCBIHuRef
CHM1_11167,234,118 - 67,237,177 (+)NCBICHM1_1
T2T-CHM13v2.01167,578,501 - 67,581,343 (+)NCBIT2T-CHM13v2.0
Gstp1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39194,085,411 - 4,087,912 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl194,085,407 - 4,087,985 (-)EnsemblGRCm39 Ensembl
GRCm38194,035,411 - 4,037,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl194,035,407 - 4,037,985 (-)EnsemblGRCm38mm10GRCm38
MGSCv37194,035,411 - 4,037,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36194,035,411 - 4,037,912 (-)NCBIMGSCv36mm8
Celera193,906,327 - 3,908,828 (-)NCBICelera
Cytogenetic Map19ANCBI
cM Map193.75NCBI
Gstp1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,914,305 - 17,917,428 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,914,228 - 17,916,918 (-)NCBIChiLan1.0ChiLan1.0
GSTP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2968,811,099 - 68,814,237 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11169,853,927 - 69,856,897 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01162,942,756 - 62,945,701 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11166,253,421 - 66,256,472 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,253,421 - 66,256,472 (+)Ensemblpanpan1.1panPan2
GSTP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11849,905,161 - 49,908,182 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1849,905,161 - 49,908,182 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1848,515,700 - 48,518,722 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01850,827,487 - 50,830,507 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1850,827,046 - 50,830,507 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11850,040,622 - 50,043,638 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01849,615,622 - 49,618,639 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01850,409,350 - 50,412,373 (-)NCBIUU_Cfam_GSD_1.0
Gstp1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049475,755,332 - 5,758,293 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365992,197,634 - 2,201,050 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365992,197,681 - 2,200,642 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC100739163
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.124,978,761 - 4,982,233 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,618,596 - 3,620,933 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GSTP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.116,676,897 - 6,679,936 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038103,955,106 - 103,991,379 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Gstp1
11 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:34
Count of miRNA genes:31
Interacting mature miRNAs:34
Transcripts:ENSRNOT00000024601
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1197814409242814409Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1196248093241248093Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1198211513225126682Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
1358292Cm37Cardiac mass QTL 376.20.00000081heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1196248093241248093Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1199773958202166723Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1197697768238755659Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1197814409242814409Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1199050459259647894Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2302375Bw83Body weight QTL 834.870.0002body mass (VT:0001259)body weight (CMO:0000012)1197697768242697768Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1197814409242814409Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1199368955224569684Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1197670404242670404Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat

Markers in Region
D1Wox36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,337,534 - 201,337,679 (+)MAPPERmRatBN7.2
Rnor_6.01219,291,452 - 219,291,596NCBIRnor6.0
Rnor_5.01226,162,103 - 226,162,247UniSTSRnor5.0
RGSC_v3.41206,627,170 - 206,627,315RGDRGSC3.4
RGSC_v3.41206,627,171 - 206,627,315UniSTSRGSC3.4
RGSC_v3.11206,780,623 - 206,780,768RGD
Celera1198,882,580 - 198,882,724UniSTS
RH 3.4 Map11559.1RGD
RH 3.4 Map11559.1UniSTS
Cytogenetic Map1q42UniSTS
RH137035  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21201,337,830 - 201,338,201 (+)MAPPERmRatBN7.2
Rnor_6.01219,291,748 - 219,292,118NCBIRnor6.0
Rnor_5.01226,162,399 - 226,162,769UniSTSRnor5.0
RGSC_v3.41206,627,467 - 206,627,837UniSTSRGSC3.4
Celera1198,882,876 - 198,883,246UniSTS
RH 3.4 Map11559.3UniSTS
Cytogenetic Map1q42UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 1
Medium 2 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024601   ⟹   ENSRNOP00000024601
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1201,321,672 - 201,340,226 (-)Ensembl
Rnor_6.0 Ensembl1219,291,679 - 219,294,147 (-)Ensembl
RefSeq Acc Id: NM_012577   ⟹   NP_036709
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,767,237 - 210,769,705 (-)NCBI
mRatBN7.21201,337,762 - 201,340,230 (-)NCBI
Rnor_6.01219,291,679 - 219,294,147 (-)NCBI
Rnor_5.01226,162,330 - 226,164,798 (-)NCBI
RGSC_v3.41206,627,398 - 206,629,866 (-)RGD
Celera1198,882,807 - 198,885,275 (-)RGD
Sequence:
RefSeq Acc Id: XM_063280727   ⟹   XP_063136797
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81210,767,240 - 210,770,242 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_036709   ⟸   NM_012577
- UniProtKB: P04906 (UniProtKB/Swiss-Prot),   B6DYQ7 (UniProtKB/TrEMBL),   A6HYR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024601   ⟸   ENSRNOT00000024601
RefSeq Acc Id: XP_063136797   ⟸   XM_063280727
- Peptide Label: isoform X1
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P04906-F1-model_v2 AlphaFold P04906 1-210 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690608
Promoter ID:EPDNEW_R1133
Type:multiple initiation site
Name:Gstp1_1
Description:glutathione S-transferase pi 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01219,294,147 - 219,294,207EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2758 AgrOrtholog
BioCyc Gene G2FUF-56782 BioCyc
BioCyc Pathway PWY-4061 [glutathione-mediated detoxification I] BioCyc
  PWY-7112 [4-hydroxy-2-nonenal detoxification] BioCyc
BioCyc Pathway Image PWY-4061 BioCyc
  PWY-7112 BioCyc
Ensembl Genes ENSRNOG00000018237 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024601 ENTREZGENE
  ENSRNOT00000024601.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6889675 IMAGE-MGC_LOAD
  IMAGE:6917961 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_pi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24426 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72668 IMAGE-MGC_LOAD
  MGC:72669 IMAGE-MGC_LOAD
NCBI Gene 24426 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GLUTATHIONE S-TRANSFERASE P 1-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB GSTP1 RGD
PhenoGen Gstp1 PhenoGen
PRINTS GSTRNSFRASEP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000018237 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217242
UniProt A6HYR6 ENTREZGENE, UniProtKB/TrEMBL
  B6DYQ7 ENTREZGENE, UniProtKB/TrEMBL
  GSTP1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-06 Gstp1  glutathione S-transferase pi 1  Gstp1  glutathione-S-transferase, pi 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Gstp1  glutathione-S-transferase, pi 1  Gstp2  glutathione S-transferase, pi 2  Data merged from RGD:1598665 737654 APPROVED
2006-12-10 Gstp2  glutathione S-transferase, pi 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-03-17 Gstp1  glutathione-S-transferase, pi 1  Gstp2  glutathione S-transferase, pi 2  Data merged from RGD:68421 737654 APPROVED
2003-04-09 Gstp1  Glutathione-S-transferase, placental enzyme pi 1  Gstp  Glutathione-S-transferase, placental enzyme pi type  Name updated 629478 APPROVED
2002-06-10 Gstp  Glutathione-S-transferase, placental enzyme pi type      Symbol and Name status set to approved 70586 APPROVED
2002-06-10 Gstp2  glutathione S-transferase, pi 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver and fibroblast cells 70479
gene_expression may be induced in response to certain types of liver damages 70249
gene_process conjugates glutathione with acceptor molecules 70479
gene_process functions in converting fat soluble chemicals to water-soluble to inhibit build-up of hydrophobic compounds in adipose 70479