Gstm2 (glutathione S-transferase mu 2) - Rat Genome Database

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Gene: Gstm2 (glutathione S-transferase mu 2) Rattus norvegicus
Analyze
Symbol: Gstm2 (Ensembl: Gstm5l)
Name: glutathione S-transferase mu 2 (Ensembl:glutathione S-transferase, mu 5-like)
RGD ID: 2756
Description: Enables glutathione binding activity; glutathione transferase activity; and identical protein binding activity. Involved in several processes, including glutathione metabolic process; response to catechin; and response to genistein. Located in cytosol. Part of protein-containing complex. Biomarker of hypertension. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to several human genes including GSTM1 (glutathione S-transferase mu 1); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-catechin; (-)-epigallocatechin 3-gallate; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase M2; glutathione S-transferase Yb-2; glutathione S-transferase Yb2 subunit; glutathione S-transferase, mu 2; Glutathione-S-transferase mu type 2 (Yb2); Glutathione-S-transferase, mu type 2 (Yb2); GST 4-4; GST Yb2; GSTA4; GSTM2-2
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bp166
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,312,179 - 198,316,962 (-)NCBIGRCr8
mRatBN7.22195,624,015 - 195,628,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,544,426 - 195,628,961 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,266,686 - 203,271,044 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,148,808 - 201,153,166 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,965,761 - 195,970,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,778,041 - 210,782,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,720,704 - 210,782,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,247,260 - 230,251,618 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,549,022 - 203,553,380NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2188,270,799 - 188,275,157 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm2RatCardiac Fibrosis treatmentIEP 401793732 RGD 
Gstm2RatCardiomegaly treatmentIEP 401793732 RGD 
Gstm2RatCOVID-19  ISOGSTM2 (Homo sapiens)9068941mRNA:decreased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Gstm2Rathypertension  IEP 2302178 RGD 
Gstm2Rathypertension treatmentIEP 401793732 RGD 
Gstm2Rathypertension  IEP 631154mRNA:decreased expression:kidney (rat)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm2Ratautistic disorder  ISOGSTM2 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Gstm2Rathereditary spastic paraplegia 63  ISOGSTM2 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 63ClinVarPMID:23911318 and PMID:28492532
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm2Ratacute kidney failure  ISOGSTM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750
Gstm2RatChemical and Drug Induced Liver Injury  ISOGSTM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750
Gstm2RatDown syndrome  ISOGSTM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:11771762
Gstm2Ratlung non-small cell carcinoma  ISOGSTM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19900515
Gstm2RatMyocardial Ischemia  ISOGSTM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
Gstm2Ratneurodegenerative disease  ISOGSTM2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15964507
Object Symbol
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Qualifier
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Reference
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Original Reference(s)
Gstm2RatLung Neoplasms  ISOGSTM1 (Homo sapiens)1331525 GAD 

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Object Symbol
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Term
Qualifier
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Notes
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Original Reference(s)
Gstm2Rat(+)-catechin decreases expressionEXP 6480464Catechin results in decreased expression of GSTM2 mRNACTDPMID:19838946
Gstm2Rat(-)-epigallocatechin 3-gallate increases expressionEXP 6480464epigallocatechin gallate results in increased expression of GSTM2 mRNA and epigallocatechin gallate results in increased expression of GSTM2 proteinCTDPMID:10927022
Gstm2Rat(1->4)-beta-D-glucan multiple interactionsISOGstm2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GSTM2 mRNA and [perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GSTM5 mRNACTDPMID:36331819
Gstm2Rat(S)-nicotine decreases expressionISOGstm2 (Mus musculus)6480464Nicotine results in decreased expression of GSTM2 mRNACTDPMID:33640489
Gstm2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionISOGstm2 (Mus musculus)6480464o and p'-DDT affects the expression of GSTM2 mRNACTDPMID:18925944
Gstm2Rat1,2-dichloroethane decreases expressionISOGstm2 (Mus musculus)6480464ethylene dichloride results in decreased expression of GSTM2 mRNACTDPMID:28189721 and PMID:28960355
Gstm2Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of GSTM2 mRNACTDPMID:32387197
Gstm2Rat1,2-dimethylhydrazine multiple interactionsISOGstm2 (Mus musculus)6480464[1 more ...CTDPMID:22206623
Gstm2Rat1,2-dimethylhydrazine decreases expressionISOGstm2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of GSTM2 mRNACTDPMID:22206623
Gstm2Rat1,4-dioxane increases expressionISOGstm2 (Mus musculus)64804641 and 4-dioxane results in increased expression of GSTM2 mRNACTDPMID:33693819
Gstm2Rat1-[(4-chlorophenyl)-phenylmethyl]-4-methylpiperazine increases expressionEXP 6480464chlorcyclizine results in increased expression of GSTM2 mRNACTDPMID:21058326
Gstm2Rat1-chloro-2,4-dinitrobenzene affects metabolic processingISOGSTM2 (Homo sapiens)6480464GSTM2 protein affects the metabolism of DinitrochlorobenzeneCTDPMID:3570286
Gstm2Rat1-chloro-2,4-dinitrobenzene affects metabolic processingISOGstm2 (Mus musculus)6480464GSTM5 protein affects the metabolism of DinitrochlorobenzeneCTDPMID:9545290
Gstm2Rat1-chloro-2,4-dinitrobenzene multiple interactionsEXP 6480464Dinitrochlorobenzene promotes the reaction [GSTM2 protein affects the metabolism of Glutathione]CTDPMID:9794801
Gstm2Rat1-chloro-2,4-dinitrobenzene affects activityEXP 6480464Dinitrochlorobenzene affects the activity of GSTM2 proteinCTDPMID:9794801
Gstm2Rat1-chloro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrochlorobenzene results in increased expression of GSTM2 proteinCTDPMID:9794801
Gstm2Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of GSTM2 mRNACTDPMID:18289764
Gstm2Rat1-naphthyl isothiocyanate increases expressionISOGstm2 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of GSTM5 mRNACTDPMID:15913567
Gstm2Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of GSTM2 mRNACTDPMID:12655037 and PMID:15576828
Gstm2Rat17alpha-ethynylestradiol decreases expressionISOGstm2 (Mus musculus)6480464Ethinyl Estradiol results in decreased expression of GSTM5 mRNACTDPMID:14976129

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Biological Process
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Original Reference(s)
Gstm2Ratcellular detoxification of nitrogen compound involved_inISOGSTM2 (Homo sapiens)1624291 PMID:2034681 and PMID:8373352RGDPMID:2034681 and PMID:8373352
Gstm2Ratcellular oxidant detoxification involved_inIEAGO:00046021600115GO_REF:0000108GOCGO_REF:0000108
Gstm2Ratcellular response to caffeine involved_inISOGSTM2 (Homo sapiens)1624291 PMID:22406107RGDPMID:22406107
Gstm2Ratglutathione metabolic process  IMP 2302181 RGD 
Gstm2Ratglutathione metabolic process involved_inIBAFB:FBgn0010226 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstm2Ratglutathione metabolic process involved_inISOGSTM2 (Homo sapiens)1624291 PMID:16549767 more ...RGDPMID:16549767 more ...
Gstm2Rathepoxilin biosynthetic process involved_inISSUniProtKB:P281611600115GO_REF:0000024UniProtGO_REF:0000024
Gstm2Rathepoxilin biosynthetic process involved_inISOGSTM2 (Homo sapiens)1624291 PMID:21046276RGDPMID:21046276
Gstm2Ratlinoleic acid metabolic process involved_inISOGSTM2 (Homo sapiens)1624291 PMID:16624487RGDPMID:16624487
Gstm2Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Gstm2Ratnitrobenzene metabolic process involved_inISOGSTM2 (Homo sapiens)1624291 PMID:2034681 and PMID:8373352RGDPMID:2034681 and PMID:8373352
Gstm2Ratregulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion involved_inISOGSTM2 (Homo sapiens)1624291 PMID:17023043RGDPMID:17023043
Gstm2Ratregulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum involved_inISOGSTM2 (Homo sapiens)1624291 PMID:17023043RGDPMID:17023043
Gstm2Ratregulation of skeletal muscle contraction by regulation of release of sequestered calcium ion involved_inISOGSTM2 (Homo sapiens)1624291 PMID:17023043RGDPMID:17023043
Gstm2Ratresponse to catechin  IEP 2302182epigallocatechin gallateRGD 
Gstm2Ratresponse to genistein  IEP 7495843 RGD 
Gstm2Ratresponse to metal ion  IEP 7495836chromium VIRGD 
Gstm2Ratsensory perception of smell involved_inIEAUniProtKB-KW:KW-05521600115GO_REF:0000043UniProtGO_REF:0000043
Gstm2Ratxenobiotic catabolic process involved_inIDA 12793043PMID:17112229CAFA 
Gstm2Ratxenobiotic catabolic process involved_inISOGSTM2 (Homo sapiens)1624291 PMID:16549767 more ...RGDPMID:16549767 more ...
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Cellular Component
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Molecular Function
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Original Reference(s)
Gstm2Ratcalcium channel inhibitor activity enablesISOGSTM2 (Homo sapiens)1624291 PMID:22406107RGDPMID:22406107
Gstm2Ratenzyme binding enablesISOGSTM2 (Homo sapiens)1624291UniProtKB:P28161 and PMID:8373352RGDPMID:8373352
Gstm2Ratfatty acid binding enablesISOGSTM2 (Homo sapiens)1624291CHEBI:72639 PMID:16624487RGDPMID:16624487
Gstm2Ratglutathione binding enablesIDA 12793043PMID:17112229CAFA 
Gstm2Ratglutathione binding enablesISOGSTM2 (Homo sapiens)1624291 PMID:2034681 and PMID:8373352RGDPMID:2034681 and PMID:8373352
Gstm2Ratglutathione peroxidase activity enablesISOGSTM2 (Homo sapiens)1624291 PMID:16624487RGDPMID:16624487
Gstm2Ratglutathione transferase activity  TAS 730286 RGD 
Gstm2Ratglutathione transferase activity enablesIEAInterPro:IPR0030811600115GO_REF:0000002InterProGO_REF:0000002
Gstm2Ratglutathione transferase activity enablesIBAFB:FBgn0010226 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstm2Ratglutathione transferase activity enablesISOGstm2 (Mus musculus)1624291 PMID:8442656RGDPMID:8442656
Gstm2Ratglutathione transferase activity enablesISOGSTM2 (Homo sapiens)1624291 PMID:16549767 more ...RGDPMID:16549767 more ...
Gstm2Ratglutathione transferase activity enablesIDA 12793043PMID:17112229CAFA 
Gstm2Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gstm2Ratidentical protein binding  IPIGstm2 (Rattus norvegicus)2293821homodimerizationRGD 
Gstm2Ratidentical protein binding enablesISOGstm2 (Mus musculus)1624291PR:P15626 PMID:2689439RGDPMID:2689439
Gstm2Ratidentical protein binding enablesIEAARBA:ARBA000279301600115GO_REF:0000117UniProtGO_REF:0000117
Gstm2Ratprotein binding enablesISOGSTM2 (Homo sapiens)1624291UniProtKB:P19712-PRO_0000038050 more ...RGDPMID:24965446 more ...
Gstm2Ratprotein binding enablesISOGstm2 (Mus musculus)1624291PR:P10649 PMID:2689439RGDPMID:2689439
Gstm2Ratprotein homodimerization activity enablesISOGSTM2 (Homo sapiens)1624291UniProtKB:P28161 and PMID:8373352RGDPMID:8373352
Gstm2Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm2Ratglutathione conjugation pathway  IAGP 631154 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gstm2Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gstm2Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gstm2Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

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#
Reference Title
Reference Citation
1. Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression. 't Hoen PA, etal., Eur J Biochem. 2002 May;269(10):2574-83.
2. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Abu-Amero KK, etal., Br J Ophthalmol. 2009 Aug;93(8):1101-4. Epub 2009 Mar 13.
3. Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients. Abu-Amero KK, etal., Mol Vis. 2008 Mar 4;14:425-30.
4. Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population. Alberti G, etal., Invest Ophthalmol Vis Sci. 1996 May;37(6):1167-73.
5. Glutathione S-transferase gene polymorphisms in presbycusis. Ates NA, etal., Otol Neurotol. 2005 May;26(3):392-7.
6. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
7. The GSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population. Carless MA, etal., J Invest Dermatol. 2002 Dec;119(6):1373-8.
8. Specific induction of glutathione S-transferase GSTM2 subunit expression by epigallocatechin gallate in rat liver. Chou FP, etal., Biochem Pharmacol. 2000 Sep 1;60(5):643-50.
9. An association between resistant hypertension and the null GSTM1 genotype. Cruz-Gonzalez I, etal., J Hum Hypertens. 2009 Aug;23(8):556-8. doi: 10.1038/jhh.2009.19. Epub 2009 Mar 12.
10. [Glutathione-S-transferase M1 genotype in patients with hepatocellular carcinoma]. Deng Z, etal., Zhonghua Zhong Liu Za Zhi. 2001 Nov;23(6):477-9.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Glutathione S-transferase M1, GSTT1 and GSTP1 genetic polymorphisms and the risk of age-related macular degeneration. Guven M, etal., Ophthalmic Res. 2011;46(1):31-7. doi: 10.1159/000321940. Epub 2011 Jan 5.
14. Detection of GST1 gene deletion by the polymerase chain reaction and its possible correlation with stomach cancer in Japanese. Harada S, etal., Hum Genet. 1992 Sep-Oct;90(1-2):62-4.
15. Inherited GSTM1 and NAT2 defects as concurrent risk modifiers in asbestos-related human malignant mesothelioma. Hirvonen A, etal., Cancer Res. 1995 Jul 15;55(14):2981-3.
16. Equilibrium folding of dimeric class mu glutathione transferases involves a stable monomeric intermediate. Hornby JA, etal., Biochemistry. 2000 Oct 10;39(40):12336-44.
17. Genetic polymorphisms in genes encoding antioxidant enzymes are associated with diabetic retinopathy in type 1 diabetes. Hovnik T, etal., Diabetes Care. 2009 Dec;32(12):2258-62. doi: 10.2337/dc09-0852. Epub 2009 Sep 14.
18. Analysis of the Glutathione S-transferase M1 gene using pyrosequencing and multiplex PCR--no evidence of association to glaucoma. Jansson M, etal., Exp Eye Res. 2003 Aug;77(2):239-43.
19. Polymorphic glutathione S-transferase M1 is a risk factor of primary open-angle glaucoma among Estonians. Juronen E, etal., Exp Eye Res. 2000 Nov;71(5):447-52.
20. Combined analysis of germline polymorphisms of p53, GSTM1, GSTT1, CYP1A1, and CYP2E1: relation to the incidence rate of cervical carcinoma. Kim JW, etal., Cancer. 2000 May 1;88(9):2082-91.
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PMID:2034681   PMID:2226415   PMID:2689439   PMID:3011803   PMID:3699019   PMID:3864155   PMID:8373352   PMID:8442656   PMID:8503873   PMID:12477932   PMID:15009649   PMID:16549767  
PMID:16624487   PMID:17023043   PMID:19056867   PMID:21046276   PMID:22406107   PMID:23376485   PMID:23533145   PMID:26316108   PMID:27612301  



Gstm2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,312,179 - 198,316,962 (-)NCBIGRCr8
mRatBN7.22195,624,015 - 195,628,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,544,426 - 195,628,961 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,266,686 - 203,271,044 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,148,808 - 201,153,166 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,965,761 - 195,970,119 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,778,041 - 210,782,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,720,704 - 210,782,856 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,247,260 - 230,251,618 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,549,022 - 203,553,380NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2188,270,799 - 188,275,157 (-)NCBICelera
Cytogenetic Map2q34NCBI
GSTM2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,668,057 - 109,683,997 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,668,022 - 109,709,551 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,210,679 - 110,226,619 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,012,214 - 110,019,431 (+)NCBINCBI36Build 36hg18NCBI36
Build 341109,922,732 - 109,929,949NCBI
Celera1108,475,704 - 108,491,676 (+)NCBICelera
Cytogenetic Map1p13.3NCBI
HuRef1108,098,937 - 108,114,955 (+)NCBIHuRef
CHM1_11110,325,465 - 110,359,901 (+)NCBICHM1_1
T2T-CHM13v2.01109,696,172 - 109,703,776 (+)NCBIT2T-CHM13v2.0
Gstm2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,889,018 - 107,893,736 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,889,018 - 107,893,769 (-)EnsemblGRCm39 Ensembl
GRCm383107,981,702 - 107,986,420 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3107,981,702 - 107,986,453 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,784,620 - 107,789,354 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,109,758 - 108,114,495 (-)NCBIMGSCv36mm8
Celera3110,314,778 - 110,319,512 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
GSTM2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v01112,043,201 - 112,050,810 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11111,272,713 - 111,278,829 (+)NCBIpanpan1.1PanPan1.1panPan2

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Variants in Gstm2
28 total Variants

Predicted Target Of
Summary Value
Count of predictions:172
Count of miRNA genes:112
Interacting mature miRNAs:125
Transcripts:ENSRNOT00000025939
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat

1 to 10 of 65 rows
RH143636  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,624,474 - 195,624,587 (+)MAPPERmRatBN7.2
Rnor_6.02210,778,501 - 210,778,613NCBIRnor6.0
Rnor_5.02230,247,373 - 230,247,485UniSTSRnor5.0
RGSC_v3.42203,549,135 - 203,549,247UniSTSRGSC3.4
Celera2188,270,912 - 188,271,024UniSTS
RH 3.4 Map21390.5UniSTS
Cytogenetic Map2q34UniSTS
Gstm2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82198,314,636 - 198,315,584 (+)Marker Load Pipeline
mRatBN7.22195,626,472 - 195,627,420 (+)MAPPERmRatBN7.2
Rnor_6.02210,780,499 - 210,781,446NCBIRnor6.0
Rnor_5.02230,249,371 - 230,250,318UniSTSRnor5.0
RGSC_v3.42203,551,133 - 203,552,080UniSTSRGSC3.4
Celera2188,272,910 - 188,273,857UniSTS
Cytogenetic Map2q34UniSTS




alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
6 6 31 34 30 18 6 18 6 58 24 19 10 19 12


1 to 20 of 20 rows
RefSeq Transcripts NM_177426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590627 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC158576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210478 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218417 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218547 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219560 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J03914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M13590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000025689   ⟹   ENSRNOP00000025689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,566,703 - 195,572,203 (-)Ensembl
Rnor_6.0 Ensembl2210,720,720 - 210,726,179 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000025746   ⟹   ENSRNOP00000025746
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,579,566 - 195,584,350 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000025800   ⟹   ENSRNOP00000025800
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,567,235 - 195,572,203 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000025939   ⟹   ENSRNOP00000025939
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,624,018 - 195,628,961 (-)Ensembl
Rnor_6.0 Ensembl2210,778,388 - 210,782,746 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077563   ⟹   ENSRNOP00000070866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,625,711 - 195,628,803 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080228   ⟹   ENSRNOP00000073859
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,544,426 - 195,549,959 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000081501   ⟹   ENSRNOP00000073172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,566,701 - 195,572,056 (-)Ensembl
Rnor_6.0 Ensembl2210,720,704 - 210,782,856 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109587   ⟹   ENSRNOP00000084446
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,579,566 - 195,584,350 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000110922   ⟹   ENSRNOP00000092883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,544,426 - 195,628,803 (-)Ensembl
RefSeq Acc Id: NM_177426   ⟹   NP_803175
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,312,179 - 198,316,917 (-)NCBI
mRatBN7.22195,624,015 - 195,628,753 (-)NCBI
Rnor_6.02210,778,388 - 210,782,746 (-)NCBI
Rnor_5.02230,247,260 - 230,251,618 (-)NCBI
RGSC_v3.42203,549,022 - 203,553,380 (-)RGD
Celera2188,270,799 - 188,275,157 (-)RGD
Sequence:
RefSeq Acc Id: XM_017590627   ⟹   XP_017446116
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,312,179 - 198,316,962 (-)NCBI
mRatBN7.22195,624,015 - 195,628,774 (-)NCBI
Rnor_6.02210,778,041 - 210,782,807 (-)NCBI
Sequence:
1 to 9 of 9 rows
Protein RefSeqs NP_803175 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446116 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41285 (Get FASTA)   NCBI Sequence Viewer  
  AAA41296 (Get FASTA)   NCBI Sequence Viewer  
  AAA42351 (Get FASTA)   NCBI Sequence Viewer  
  ACI32119 (Get FASTA)   NCBI Sequence Viewer  
  EDL81904 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000025800
GenBank Protein P08010 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
1 to 5 of 11 rows
1 to 5 of 11 rows
RefSeq Acc Id: NP_803175   ⟸   NM_177426
- UniProtKB: P08010 (UniProtKB/Swiss-Prot),   B6DYQ2 (UniProtKB/TrEMBL),   A0A8L2QDS2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446116   ⟸   XM_017590627
- Peptide Label: isoform X1
- UniProtKB: A6HUW9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000073172   ⟸   ENSRNOT00000081501
Ensembl Acc Id: ENSRNOP00000025939   ⟸   ENSRNOT00000025939
Ensembl Acc Id: ENSRNOP00000025689   ⟸   ENSRNOT00000025689
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZ09-F1-model_v2 AlphaFold A0A0G2JZ09 1-215 view protein structure
AF-P08010-F1-model_v2 AlphaFold P08010 1-218 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691668
Promoter ID:EPDNEW_R2193
Type:initiation region
Name:Gstm2_1
Description:glutathione S-transferase mu 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,782,779 - 210,782,839EPDNEW


1 to 37 of 37 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51642 BioCyc
Ensembl Genes ENSRNOG00000018937 Ensembl
  ENSRNOG00000060939 Ensembl
  ENSRNOG00000071330 ENTREZGENE
Ensembl Transcript ENSRNOT00000025800 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_mu UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:24424 UniProtKB/Swiss-Prot
NCBI Gene 24424 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE MU 2 UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PhenoGen Gstm2 PhenoGen
PRINTS GSTRNSFRASEM UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018937 RatGTEx
  ENSRNOG00000060939 RatGTEx
  ENSRNOG00000071330 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A0A0G2JZ09_RAT UniProtKB/TrEMBL
  A0A8I6A1B0_RAT UniProtKB/TrEMBL
  A0A8L2QDS2 ENTREZGENE, UniProtKB/TrEMBL
  A6HUW9 ENTREZGENE, UniProtKB/TrEMBL
  B6DYQ2 ENTREZGENE, UniProtKB/TrEMBL
  G3V8H3_RAT UniProtKB/TrEMBL
  GSTM2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 37 of 37 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-04 Gstm2  glutathione S-transferase mu 2  Gstm2  glutathione S-transferase M2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-03 Gstm2  glutathione S-transferase M2  Gstm2  glutathione S-transferase, mu 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gstm2  Glutathione-S-transferase, mu type 2 (Yb2)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression reduced expression is associated with high blood pressure and oxidative stress in the stroke-prone spontaneously hypertensive (SHRSP) rat strain 631154
gene_function catalyzes the conjugation of electrophilic compounds to glutathione 631154
gene_process mediates cellular resistance against oxidative stress 631154
gene_product member of the family of glutathione S-transferases 631154