Gstm1 (glutathione S-transferase mu 1) - Rat Genome Database

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Gene: Gstm1 (glutathione S-transferase mu 1) Rattus norvegicus
Analyze
Symbol: Gstm1
Name: glutathione S-transferase mu 1
RGD ID: 2755
Description: Enables several functions, including glutathione binding activity; glutathione transferase activity; and nickel cation binding activity. Involved in several processes, including glutathione metabolic process; response to ethanol; and response to lead ion. Located in cytosol and extracellular region. Part of protein-containing complex. Used to study cholestasis. Biomarker of hypertension and liver cirrhosis. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung disease (multiple). Orthologous to human GSTM1 (glutathione S-transferase mu 1); PARTICIPATES IN cyclophosphamide pharmacodynamics pathway; cyclophosphamide pharmacokinetics pathway; glutathione conjugation pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; (R,R,R)-alpha-tocopherol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione S-transferase M1; glutathione S-transferase Yb-1 subunit; glutathione S-transferase, mu 1; glutathione-S-transferase mu type 1 (Yb1); Glutathione-S-transferase, mu type 1 (Yb1); GST 3-3; GST Yb1; GSTA3; GSTM1-1
RGD Orthologs
Human
Mouse
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SHRSP.WKY-(D2Wox9-D2Mgh12)/Gcrc   SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc   SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,338,005 - 198,346,007 (-)NCBIGRCr8
mRatBN7.22195,649,845 - 195,655,402 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,649,845 - 195,655,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,292,372 - 203,297,745 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,174,485 - 201,179,858 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,991,446 - 195,996,819 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,803,869 - 210,809,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,803,869 - 210,809,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,272,740 - 230,278,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,575,444 - 203,580,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,538,197 - 203,543,575 (-)NCBI
Celera2188,295,244 - 188,300,621 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Gstm1Ratacute chest syndrome susceptibilityISOGSTM1 (Homo sapiens)10450838associated with sickle cell anemiaRGD 
Gstm1Ratacute lymphoblastic leukemia susceptibilityISOGSTM1 (Homo sapiens)10755321 RGD 
Gstm1Ratacute lymphoblastic leukemia disease_progressionISOGSTM1 (Homo sapiens)10450829 RGD 
Gstm1Ratacute lymphoblastic leukemia no_associationISOGSTM1 (Homo sapiens)10755409 RGD 
Gstm1Ratacute lymphoblastic leukemia susceptibilityISOGSTM1 (Homo sapiens)10755410 RGD 
Gstm1Ratacute myeloid leukemia disease_progressionISOGSTM1 (Homo sapiens)10755318DNA:deletion: : (human)RGD 
Gstm1Ratacute myeloid leukemia susceptibilityISOGSTM1 (Homo sapiens)10450822 RGD 
Gstm1Ratacute myeloid leukemia disease_progressionISOGSTM1 (Homo sapiens)10755405DNA:methylation: :RGD 
Gstm1Ratadenocarcinoma susceptibilityISOGSTM1 (Homo sapiens)7488952colon and stomach and protein:decreased activity:liver (human)RGD 
Gstm1Rataggressive periodontitis  ISOGSTM1 (Homo sapiens)14700939 RGD 
Gstm1RatAlcoholic Liver Diseases  ISOGSTM1 (Homo sapiens)14700973 RGD 
Gstm1RatAlcoholic Liver Diseases  ISOGSTM1 (Homo sapiens)11060494 RGD 
Gstm1Ratallergic disease susceptibilityISOGSTM1 (Homo sapiens)5490996DNA:deletion: :RGD 
Gstm1Ratangle-closure glaucoma susceptibilityISOGSTM1 (Homo sapiens)7488955DNA:deletion and haplotype:cds (human)RGD 
Gstm1Rataplastic anemia susceptibilityISOGSTM1 (Homo sapiens)10450858in maleRGD 
Gstm1Ratasbestosis susceptibilityISOGSTM1 (Homo sapiens)5490588DNA:deletion: :RGD 
Gstm1Ratasphyxia neonatorum severityISOGSTM1 (Homo sapiens)12792218DNA:deletion and haplotype:: (human)RGD 
Gstm1Ratasthma  ISOGSTM1 (Homo sapiens)5490962 RGD 
Gstm1Ratasthma susceptibilityISOGSTM1 (Homo sapiens)4140921DNA:deletion: :RGD 
Gstm1Ratasthma resistanceISOGSTM1 (Homo sapiens)4142509DNA:deletion: :RGD 
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Gstm1Ratautistic disorder  ISOGSTM1 (Homo sapiens)8554872ClinVar Annotator: match by term: AutismClinVarPMID:21681106 and PMID:30208311
Gstm1Rathereditary spastic paraplegia 63  ISOGSTM1 (Homo sapiens)8554872ClinVar Annotator: match by term: Hereditary spastic paraplegia 63ClinVarPMID:23911318 and PMID:28492532
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Gstm1Ratamphetamine abuse  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19254865
Gstm1Ratasthma  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16870661 and PMID:18988661
Gstm1Ratatherosclerosis  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19822795
Gstm1Ratautism spectrum disorder  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Gstm1Ratautistic disorder  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16472391
Gstm1RatChemical and Drug Induced Liver Injury  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17465707 and PMID:18666253
Gstm1RatChloracne  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17101203
Gstm1RatChromosome Aberrations  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23159492 and PMID:24036326
Gstm1RatChromosome Breakage  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27406225
Gstm1RatColorectal Neoplasms  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20878130
Gstm1RatDisease Susceptibility  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16537716 and PMID:31569996
Gstm1Ratdrug allergy  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20485159
Gstm1RatExperimental Liver Cirrhosis  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15650968
Gstm1RatGenetic Predisposition to Disease  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24036326
Gstm1Rathepatocellular carcinoma  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:7892276
Gstm1Ratleukemia  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:14694614 and PMID:18505952
Gstm1RatLiver Neoplasms  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21214675
Gstm1RatLung Neoplasms  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17114358 more ...
Gstm1Ratmalignant mesothelioma  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16697254
Gstm1RatMesothelioma  ISOGSTM1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17290392
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Gstm1RatLung Neoplasms  ISOGSTM5 (Homo sapiens)1331525 GAD 
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Gstm1Ratautism spectrum disorder  ISSGstm1 (Mus musculus)13592920 MouseDO 

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Gstm1Rat(+)-schisandrin B multiple interactionsEXP 6480464schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of GSTM1 mRNA]CTDPMID:31150632
Gstm1Rat(+)-taxifolin increases expressionISOGSTM1 (Homo sapiens)6480464taxifolin results in increased expression of GSTM1 mRNACTDPMID:17541156
Gstm1Rat(-)-epigallocatechin 3-gallate increases expressionISOGstm1 (Mus musculus)6480464epigallocatechin gallate results in increased expression of GSTM1 mRNACTDPMID:25585349
Gstm1Rat(1->4)-beta-D-glucan multiple interactionsISOGstm1 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GSTM1 mRNACTDPMID:36331819
Gstm1Rat(R)-lipoic acid multiple interactionsISOGstm1 (Mus musculus)6480464[Dietary Fats co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNACTDPMID:18367378
Gstm1Rat(R)-lipoic acid multiple interactionsEXP 6480464[Diethylnitrosamine co-treated with Thioacetamide co-treated with Thioctic Acid] results in increased expression of GSTM1 mRNACTDPMID:23830814
Gstm1Rat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464[alpha-Tocopherol co-treated with beta-Tocopherol co-treated with gamma-Tocopherol co-treated with delta-tocopherol] affects the reaction [Estradiol affects the expression of GSTM1 mRNA]CTDPMID:22389237
Gstm1Rat1,1-dichloroethene decreases expressionISOGstm1 (Mus musculus)6480464vinylidene chloride results in decreased expression of GSTM1 mRNACTDPMID:26682919
Gstm1Rat1,2-dimethylhydrazine decreases expressionISOGstm1 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of GSTM1 mRNACTDPMID:22206623
Gstm1Rat1,2-dimethylhydrazine multiple interactionsISOGstm1 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of GSTM1 mRNACTDPMID:22206623
Gstm1Rat1,4-dichlorobenzene increases expressionISOGstm1 (Mus musculus)64804644-dichlorobenzene results in increased expression of GSTM1 mRNACTDPMID:28541575
Gstm1Rat1,4-dioxane increases expressionISOGstm1 (Mus musculus)64804641 and 4-dioxane results in increased expression of GSTM1 mRNACTDPMID:33693819
Gstm1Rat1-aminobenzotriazole multiple interactionsISOGstm1 (Mus musculus)64804641-aminobenzotriazole affects the reaction [propylene dichloride results in increased expression of GSTM1 protein]CTDPMID:32435916
Gstm1Rat1-benzofuran affects expressionISOGstm1 (Mus musculus)6480464benzofuran affects the expression of GSTM1 mRNACTDPMID:17114358
Gstm1Rat1-chloro-2,4-dinitrobenzene affects metabolic processingISOGSTM1 (Homo sapiens)6480464GSTM1 protein affects the metabolism of DinitrochlorobenzeneCTDPMID:3570286 and PMID:9545290
Gstm1Rat1-chloro-2,4-dinitrobenzene decreases expressionISOGstm1 (Mus musculus)6480464Dinitrochlorobenzene results in decreased expression of GSTM1 mRNACTDPMID:21404309
Gstm1Rat1-chloro-2,4-dinitrobenzene affects expressionISOGstm1 (Mus musculus)6480464Dinitrochlorobenzene affects the expression of GSTM1 mRNACTDPMID:28219650
Gstm1Rat1-chloro-2,4-dinitrobenzene increases glutathionylationISOGSTM1 (Homo sapiens)6480464GSTM1 protein results in increased glutathionylation of DinitrochlorobenzeneCTDPMID:28762043
Gstm1Rat1-chloro-2,4-dinitrobenzene affects bindingISOGSTM1 (Homo sapiens)6480464Dinitrochlorobenzene binds to GSTM1 proteinCTDPMID:22085405
Gstm1Rat1-chloro-2,4-dinitrobenzene multiple interactionsEXP 6480464GSTM1 protein affects the metabolism of [Dinitrochlorobenzene co-treated with Glutathione analog]CTDPMID:2904809

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Biological Process
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Gstm1Ratcellular detoxification of nitrogen compound involved_inISOGSTM1 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm1Ratcellular response to xenobiotic stimulus acts_upstream_of_or_withinIEAUniProtKB:P10649 and ensembl:ENSMUSP000000041401600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm1Ratcellular response to xenobiotic stimulus acts_upstream_of_or_withinISOGstm1 (Mus musculus)1624291 PMID:8512323RGDPMID:8512323
Gstm1Ratglutathione derivative biosynthetic process involved_inISSUniProtKB:P094881600115GO_REF:0000024UniProtGO_REF:0000024
Gstm1Ratglutathione derivative biosynthetic process involved_inISOGSTM1 (Homo sapiens)1624291 PMID:9084911RGDPMID:9084911
Gstm1Ratglutathione metabolic process  IMP 2302181 RGD 
Gstm1Ratglutathione metabolic process involved_inIBAFB:FBgn0010226 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstm1Ratglutathione metabolic process involved_inISOGSTM1 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm1Ratglutathione metabolic process involved_inIDA 70307PMID:10229687UniProt 
Gstm1Rathepoxilin biosynthetic process involved_inISOGSTM1 (Homo sapiens)1624291 PMID:21046276RGDPMID:21046276
Gstm1Rathepoxilin biosynthetic process involved_inISSUniProtKB:P094881600115GO_REF:0000024UniProtGO_REF:0000024
Gstm1Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Gstm1Ratnitrobenzene metabolic process involved_inISOGSTM1 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm1Ratprostaglandin metabolic process involved_inISSUniProtKB:P094881600115GO_REF:0000024UniProtGO_REF:0000024
Gstm1Ratprostaglandin metabolic process involved_inISOGSTM1 (Homo sapiens)1624291 PMID:9084911RGDPMID:9084911
Gstm1Ratresponse to amino acid  IEP 2293820 RGD 
Gstm1Ratresponse to axon injury  IEP 7771530 RGD 
Gstm1Ratresponse to ethanol  IEP 7495839 RGD 
Gstm1Ratresponse to lead ion  IEP 7495837 RGD 
Gstm1Ratresponse to metal ion  IEP 7495836chromium VIRGD 
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Cellular Component
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Gstm1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gstm1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gstm1Ratcytoplasm located_inISOGSTM1 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm1Ratcytosol located_inISOGstm1 (Mus musculus)1624291 PMID:15100242RGDPMID:15100242
Gstm1Ratcytosol located_inIEAUniProtKB:P10649 and ensembl:ENSMUSP000000041401600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm1Ratcytosol located_inISOGSTM1 (Homo sapiens) and UniProtKB:P09488-11624291 RGDGO_REF:0000052
Gstm1Ratcytosol located_inIDA 12793043PMID:17112229CAFA 
Gstm1Ratextracellular region  IDA 70307 RGD 
Gstm1Ratmitochondrion located_inISOGstm1 (Mus musculus)1624291 PMID:12020353 and PMID:15100242RGDPMID:12020353 and PMID:15100242
Gstm1Ratmitochondrion located_inIEAUniProtKB:P10649 and ensembl:ENSMUSP000000041401600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm1Ratprotein-containing complex  IDA 2293821 RGD 
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Molecular Function
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Gstm1Ratenzyme binding enablesISOGSTM1 (Homo sapiens)1624291UniProtKB:P09488 and PMID:8373352RGDPMID:8373352
Gstm1Ratglutathione binding enablesISOGSTM1 (Homo sapiens)1624291 PMID:8373352RGDPMID:8373352
Gstm1Ratglutathione binding enablesIDA 12793043PMID:17112229CAFA 
Gstm1Ratglutathione transferase activity  IDA 70307 RGD 
Gstm1Ratglutathione transferase activity enablesIBAFB:FBgn0010226 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gstm1Ratglutathione transferase activity enablesISOGSTM1 (Homo sapiens)1624291 PMID:8373352 and PMID:9084911RGDPMID:8373352 and PMID:9084911
Gstm1Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gstm1Ratglutathione transferase activity enablesIEAInterPro:IPR0030811600115GO_REF:0000002InterProGO_REF:0000002
Gstm1Ratglutathione transferase activity enablesIDA 12793043PMID:17112229CAFA 
Gstm1Ratidentical protein binding  IPIGstm1 (Rattus norvegicus)2293821homodimerizationRGD 
Gstm1Ratidentical protein binding enablesIEAUniProtKB:P10649 and ensembl:ENSMUSP000000041401600115GO_REF:0000107EnsemblGO_REF:0000107
Gstm1Ratidentical protein binding enablesISOGstm1 (Mus musculus)1624291PR:P10649 PMID:2689439RGDPMID:2689439
Gstm1Ratidentical protein binding enablesIEAARBA:ARBA000279301600115GO_REF:0000117UniProtGO_REF:0000117
Gstm1Ratnickel cation binding  IDA 7771537 RGD 
Gstm1Ratprotein binding enablesISOGstm1 (Mus musculus)1624291PR:P15626 more ...RGDPMID:19706271 and PMID:2689439
Gstm1Ratprotein homodimerization activity enablesISOGSTM1 (Homo sapiens)1624291UniProtKB:P09488 and PMID:8373352RGDPMID:8373352
Gstm1Ratprotein kinase binding  IPIPrkab2 (Rattus norvegicus)10401936 RGD 
Gstm1Ratsteroid binding  IPIPubChem_Substance:459470307 RGD 
Gstm1Ratsteroid binding  IPIPubChem_Substance:575770307 RGD 
Gstm1Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
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RGD Manual Annotations


  
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Gstm1Ratglutathione conjugation pathway  ISS 1358120 RGD 

Imported Annotations - SMPDB

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Gstm1Ratcyclophosphamide pharmacodynamics pathway  ISOGSTM1 (Homo sapiens)10402751 SMPDBSMP:00447
Gstm1Ratcyclophosphamide pharmacokinetics pathway  ISOGSTM1 (Homo sapiens)10402751 SMPDBSMP:00604

Imported Annotations - KEGG (archival)

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Gstm1Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gstm1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gstm1Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

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Reference Title
Reference Citation
1. Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression. 't Hoen PA, etal., Eur J Biochem. 2002 May;269(10):2574-83.
2. Oxidative stress in the denervated muscle. Abruzzo PM, etal., Free Radic Res. 2010 May;44(5):563-76. doi: 10.3109/10715761003692487.
3. T null and M null genotypes of the glutathione S-transferase gene are risk factor for CAD independent of smoking. Abu-Amero KK, etal., BMC Med Genet. 2006 Apr 19;7:38.
4. GSTM1 and GSTT1 deletion genotypes in various spontaneous optic neuropathies in Arabs. Abu-Amero KK, etal., Br J Ophthalmol. 2009 Aug;93(8):1101-4. Epub 2009 Mar 13.
5. Glutathione S-transferase M1 and T1 polymorphisms in Arab glaucoma patients. Abu-Amero KK, etal., Mol Vis. 2008 Mar 4;14:425-30.
6. Positive correlation between single or combined genotypes of CYP1A1 and GSTM1 in relation to prostate cancer in Chilean people. Acevedo C, etal., Prostate. 2003 Oct 1;57(2):111-7. doi: 10.1002/pros.10274.
7. GSTM1 and mEPHX polymorphisms in Parkinson's disease and age of onset. Ahmadi A, etal., Biochem Biophys Res Commun. 2000 Mar 24;269(3):676-80.
8. Glutathione S-transferase M1 genotype and age-related cataracts. Lack of association in an Italian population. Alberti G, etal., Invest Ophthalmol Vis Sci. 1996 May;37(6):1167-73.
9. Genetic polymorphisms in folate pathway enzymes, DRD4 and GSTM1 are related to temporomandibular disorder. Aneiros-Guerrero A, etal., BMC Med Genet. 2011 May 26;12:75.
10. Influence of glutathione S-transferase gene polymorphisms on busulfan pharmacokinetics and outcome of hematopoietic stem-cell transplantation in thalassemia pediatric patients. Ansari M, etal., Bone Marrow Transplant. 2016 Mar;51(3):377-83. doi: 10.1038/bmt.2015.321. Epub 2015 Dec 21.
11. Methemoglobinemia induced by 1,2-dichloro-4-nitrobenzene in mice with a disrupted glutathione S-transferase Mu 1 gene. Arakawa S, etal., Drug Metab Dispos. 2010 Sep;38(9):1545-52. doi: 10.1124/dmd.110.033597. Epub 2010 Jun 18.
12. Lack of association between the glutathione-s-transferase genes (GSTT1 and GSTM1) and nasal polyposis. Arbag H, etal., Rhinology. 2006 Mar;44(1):14-8.
13. A proteomic analysis of liver after ethanol binge in chronically ethanol treated rats. Aroor AR, etal., Proteome Sci. 2012 Apr 30;10(1):29. doi: 10.1186/1477-5956-10-29.
14. Increased risk for acute myeloid leukaemia in individuals with glutathione S-transferase mu 1 (GSTM1) and theta 1 (GSTT1) gene defects. Arruda VR, etal., Eur J Haematol. 2001 Jun;66(6):383-8.
15. Genetic polymorphism of glutathione S transferases M1 and T1 in Indian patients with hepatocellular carcinoma. Asim M, etal., Dis Markers. 2010;28(6):369-76. doi: 10.3233/DMA-2010-0717.
16. Glutathione S-transferase gene polymorphisms in presbycusis. Ates NA, etal., Otol Neurotol. 2005 May;26(3):392-7.
17. Effect of glutathione S-transferases on the survival of patients with acute myeloid leukaemia. Autrup JL, etal., Eur J Pharmacol. 2002 Mar 1;438(1-2):15-8.
18. Characterization of MTHFR, GSTM1, GSTT1, GSTP1, and CYP1A1 genotypes in childhood acute leukemia. Balta G, etal., Am J Hematol. 2003 Jul;73(3):154-60.
19. Glutathione S-transferase M1 and T1 polymorphisms may predict adverse effects after therapy in children with medulloblastoma. Barahmani N, etal., Neuro Oncol. 2009 Jun;11(3):292-300. Epub 2008 Oct 24.
20. Peculiarities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronic bronchitis. Baranova H, etal., Hum Genet. 1997 Jun;99(6):822-6.
1 to 20 of 238 rows
PMID:1416995   PMID:1420139   PMID:1883338   PMID:2226415   PMID:2669745   PMID:2689439   PMID:2875437   PMID:3011803   PMID:3864155   PMID:8110735   PMID:8373352   PMID:8503873  
PMID:8512323   PMID:9084911   PMID:12826697   PMID:15009649   PMID:15299462   PMID:15489334   PMID:16475815   PMID:16672236   PMID:16800819   PMID:17634366   PMID:20387083   PMID:20517701  
PMID:21046276   PMID:25931508   PMID:30053369   PMID:30308595  



Gstm1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82198,338,005 - 198,346,007 (-)NCBIGRCr8
mRatBN7.22195,649,845 - 195,655,402 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2195,649,845 - 195,655,411 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2203,292,372 - 203,297,745 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02201,174,485 - 201,179,858 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02195,991,446 - 195,996,819 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02210,803,869 - 210,809,461 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2210,803,869 - 210,809,306 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02230,272,740 - 230,278,278 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42203,575,444 - 203,580,821 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12203,538,197 - 203,543,575 (-)NCBI
Celera2188,295,244 - 188,300,621 (-)NCBICelera
Cytogenetic Map2q34NCBI
GSTM1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381109,687,817 - 109,693,745 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1109,687,814 - 109,709,039 (+)EnsemblGRCh38hg38GRCh38
GRCh371110,230,439 - 110,236,367 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361110,031,965 - 110,037,890 (+)NCBINCBI36Build 36hg18NCBI36
Build 341109,942,483 - 109,948,409NCBI
Cytogenetic Map1p13.3NCBI
Gstm1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393107,919,566 - 107,925,289 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3107,919,571 - 107,925,289 (-)EnsemblGRCm39 Ensembl
GRCm383108,012,250 - 108,017,973 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3108,012,255 - 108,017,973 (-)EnsemblGRCm38mm10GRCm38
MGSCv373107,815,168 - 107,820,891 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363108,140,314 - 108,146,029 (-)NCBIMGSCv36mm8
Celera3110,345,820 - 110,351,544 (-)NCBICelera
Cytogenetic Map3F2.3NCBI
cM Map346.83NCBI
GSTM1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21117,352,220 - 117,358,253 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11116,495,332 - 116,506,288 (-)NCBINHGRI_mPanPan1
PanPan1.11128,003,736 - 128,009,696 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1127,979,238 - 128,010,411 (-)Ensemblpanpan1.1panPan2
LOC103224275
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12023,854,969 - 23,861,634 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023670255134 - 1,611 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

.

.
Variants in Gstm1
19 total Variants

Predicted Target Of
Summary Value
Count of predictions:265
Count of miRNA genes:163
Interacting mature miRNAs:177
Transcripts:ENSRNOT00000047139
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 65 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
152025245Scl81Serum cholesterol level QTL 813.49blood cholesterol amount (VT:0000180)2122609194206936711Rat
61458Bp10Blood pressure QTL 103.42arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189020722215287351Rat

1 to 10 of 65 rows
D2Got198  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,650,753 - 195,650,901 (+)MAPPERmRatBN7.2
Rnor_6.02210,804,777 - 210,804,922NCBIRnor6.0
Rnor_5.02230,273,648 - 230,273,793UniSTSRnor5.0
RGSC_v3.42203,576,351 - 203,576,496RGDRGSC3.4
RGSC_v3.42203,576,352 - 203,576,497UniSTSRGSC3.4
RGSC_v3.12203,539,105 - 203,539,250RGD
Celera2188,296,152 - 188,296,297UniSTS
RH 3.4 Map21377.1RGD
RH 3.4 Map21377.1UniSTS
Cytogenetic Map2q34UniSTS
BI281611  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,650,110 - 195,650,263 (+)MAPPERmRatBN7.2
Rnor_6.02210,804,134 - 210,804,286NCBIRnor6.0
Rnor_5.02230,273,005 - 230,273,157UniSTSRnor5.0
RGSC_v3.42203,575,709 - 203,575,861UniSTSRGSC3.4
Celera2188,295,509 - 188,295,661UniSTS
RH 3.4 Map21390.1UniSTS
Cytogenetic Map2q34UniSTS
Gstm1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22195,652,603 - 195,653,848 (+)MAPPERmRatBN7.2
Rnor_6.02210,806,625 - 210,807,869NCBIRnor6.0
Rnor_5.02230,275,496 - 230,276,740UniSTSRnor5.0
RGSC_v3.42203,578,200 - 203,579,444UniSTSRGSC3.4
Celera2188,298,000 - 188,299,244UniSTS
Cytogenetic Map2q34UniSTS


The following Strains have been annotated to Gstm1
SHRSP.WKY-(D2Mit21-D2Rat157)/Gcrc     SHRSP.WKY-(D2Rat13-D2Rat157)/Gcrc     SHRSP.WKY-(D2Wox9-D2Mgh12)/Gcrc    




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31


1 to 26 of 26 rows
RefSeq Transcripts NM_017014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590626 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063281290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC063172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213204 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213562 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218381 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229836 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M11719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M28241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X04229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 26 of 26 rows

Ensembl Acc Id: ENSRNOT00000047139   ⟹   ENSRNOP00000039050
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,649,848 - 195,655,411 (-)Ensembl
Rnor_6.0 Ensembl2210,803,869 - 210,809,306 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000104497   ⟹   ENSRNOP00000083172
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,649,845 - 195,655,411 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109885   ⟹   ENSRNOP00000092984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2195,649,845 - 195,655,411 (-)Ensembl
RefSeq Acc Id: NM_017014   ⟹   NP_058710
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,338,006 - 198,343,383 (-)NCBI
mRatBN7.22195,649,846 - 195,655,225 (-)NCBI
Rnor_6.02210,803,869 - 210,809,246 (-)NCBI
Rnor_5.02230,272,740 - 230,278,278 (-)NCBI
RGSC_v3.42203,575,444 - 203,580,821 (-)RGD
Celera2188,295,244 - 188,300,621 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101714   ⟹   XP_038957642
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,338,005 - 198,346,007 (-)NCBI
mRatBN7.22195,649,845 - 195,655,402 (-)NCBI
RefSeq Acc Id: XM_063281290   ⟹   XP_063137360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82198,338,005 - 198,342,992 (-)NCBI
1 to 11 of 11 rows
Protein RefSeqs NP_058710 (Get FASTA)   NCBI Sequence Viewer  
  XP_038957642 (Get FASTA)   NCBI Sequence Viewer  
  XP_063137360 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41286 (Get FASTA)   NCBI Sequence Viewer  
  AAA41287 (Get FASTA)   NCBI Sequence Viewer  
  AAA41293 (Get FASTA)   NCBI Sequence Viewer  
  AAH63172 (Get FASTA)   NCBI Sequence Viewer  
  ACI32118 (Get FASTA)   NCBI Sequence Viewer  
  CAA27811 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000039050
GenBank Protein P04905 (Get FASTA)   NCBI Sequence Viewer  
1 to 11 of 11 rows
RefSeq Acc Id: NP_058710   ⟸   NM_017014
- UniProtKB: P04905 (UniProtKB/Swiss-Prot),   G3V983 (UniProtKB/TrEMBL),   A6HUX0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000039050   ⟸   ENSRNOT00000047139
RefSeq Acc Id: XP_038957642   ⟸   XM_039101714
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000083172   ⟸   ENSRNOT00000104497
Ensembl Acc Id: ENSRNOP00000092984   ⟸   ENSRNOT00000109885
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P04905-F1-model_v2 AlphaFold P04905 1-218 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691669
Promoter ID:EPDNEW_R2194
Type:multiple initiation site
Name:Gstm1_1
Description:glutathione S-transferase mu 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02210,809,281 - 210,809,341EPDNEW


1 to 33 of 33 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51641 BioCyc
Ensembl Genes ENSRNOG00000029726 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000047139 ENTREZGENE
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920688 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_mu UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:24423 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72887 IMAGE-MGC_LOAD
NCBI Gene 24423 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE MU 1 UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PharmGKB GSTM1 RGD
PhenoGen Gstm1 PhenoGen
PRINTS GSTRNSFRASEM UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000029726 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A0A8I6AIM5_RAT UniProtKB/TrEMBL
  A0A8I6G8J9_RAT UniProtKB/TrEMBL
  A6HUX0 ENTREZGENE, UniProtKB/TrEMBL
  G3V983 ENTREZGENE, UniProtKB/TrEMBL
  GSTM1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 33 of 33 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-02-04 Gstm1  glutathione S-transferase mu 1  Gstm1  glutathione S-transferase M1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-03 Gstm1  glutathione S-transferase M1  Gstm1  glutathione S-transferase, mu 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Gstm1  glutathione S-transferase, mu 1      Symbol and Name status set to approved 625702 APPROVED
2002-06-10 Gstm1  glutathione S-transferase, mu 1      Name updated 70585 PROVISIONAL

Note Type Note Reference
gene_expression expressed in liver and fibroblast cells 70479
gene_expression secreted by sertoli cells 70307
gene_expression mRNA expressed in prostate 728523
gene_function binds steroids, including testosterone and estradiol 70307
gene_process interacts with one of 13 subunits to form the active enzyme 70479
gene_process functions in converting fat soluble chemicals to water-soluble to inhibit build-up of hydrophobic compounds in adipose tissue 70479
gene_process essential for spermatogenesis 70307
gene_process may be important for androgen-dependent growth of prostate 728523
gene_product member of glutathione-S-transferase family 728523
gene_protein protein has five distinct subunits 70479
gene_protein isoforms share extensive N-terminal homology and molecular mass 70307
gene_regulation mRNA downregulated by androgen in rat prostate 728523