Gsta2 (glutathione S-transferase alpha 2) - Rat Genome Database

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Gene: Gsta2 (glutathione S-transferase alpha 2) Rattus norvegicus
Analyze
Symbol: Gsta2
Name: glutathione S-transferase alpha 2
RGD ID: 2754
Description: Enables several functions, including dinitrosyl-iron complex binding activity; glutathione binding activity; and glutathione transferase activity. Involved in xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to several human genes including GSTA2 (glutathione S-transferase alpha 2); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (RS)-goitrin; 1,2-dimethylhydrazine; 1-Cyano-2-hydroxy-3-butene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 13-hydroperoxyoctadecadienoate peroxidase; androst-5-ene-3,17-dione isomerase; glutathione S-transferase A2; glutathione S-transferase alpha-1; glutathione S-transferase Ya subunit; glutathione S-transferase Ya-1; glutathione S-transferase, alpha 2; Glutathione-S-transferase alpha type (Yc?); Glutathione-S-transferase, alpha type (Yc?); glutathione-S-transferase, alpha type2; GST 1-1; GST 1a-1a; GST A1-1; GST B; GST Ya1; Gsta1; ligandin
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8888,064,829 - 88,077,168 (-)NCBIGRCr8
mRatBN7.2879,184,535 - 79,196,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,184,322 - 79,196,798 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,705,976 - 84,719,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,982,644 - 82,995,978 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,805,340 - 80,818,674 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,640,081 - 85,645,621 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0885,197,052 - 85,202,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,299,249 - 83,312,958 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1883,318,303 - 83,332,012 (-)NCBI
Celera878,931,925 - 78,944,156 (-)NCBICelera
Cytogenetic Map8q31NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta2Ratautism spectrum disorder  ISOGSTA2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:35663546
Gsta2RatExperimental Liver Cirrhosis  ISOGSTA2 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17072980

1 to 20 of 450 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta2Rat(1->4)-beta-D-glucan multiple interactionsISOGsta2 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in increased expression of GSTA2 mRNACTDPMID:36331819
Gsta2Rat(RS)-goitrin increases expressionEXP 6480464goitrin results in increased expression of GSTA2 proteinCTDPMID:7532609
Gsta2Rat(RS)-goitrin multiple interactionsEXP 6480464Triiodothyronine inhibits the reaction [goitrin results in increased expression of GSTA2 protein]CTDPMID:7532609
Gsta2Rat(S)-amphetamine multiple interactionsISOGsta2 (Mus musculus)6480464SOD1 inhibits the reaction [Dextroamphetamine results in increased expression of GSTA2 mRNA]CTDPMID:12205029
Gsta2Rat(S)-amphetamine increases expressionISOGsta2 (Mus musculus)6480464Dextroamphetamine results in increased expression of GSTA2 mRNACTDPMID:12205029
Gsta2Rat1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane affects expressionISOGsta2 (Mus musculus)6480464o and p'-DDT affects the expression of GSTA2 mRNACTDPMID:18925944
Gsta2Rat1,2-dimethylhydrazine decreases expressionEXP 64804641 and 2-Dimethylhydrazine results in decreased expression of GSTA2 mRNACTDPMID:32387197
Gsta2Rat1,2-dimethylhydrazine decreases expressionISOGsta2 (Mus musculus)64804641 and 2-Dimethylhydrazine results in decreased expression of GSTA2 mRNACTDPMID:22206623
Gsta2Rat1-chloro-2,4-dinitrobenzene increases metabolic processingISOGSTA2 (Homo sapiens)6480464GSTA2 protein results in increased metabolism of DinitrochlorobenzeneCTDPMID:3138230
Gsta2Rat1-chloro-2,4-dinitrobenzene decreases metabolic processingISOGSTA2 (Homo sapiens)6480464GSTA2 protein polymorphism results in decreased metabolism of DinitrochlorobenzeneCTDPMID:15077012 and PMID:15128049
Gsta2Rat1-Cyano-2-hydroxy-3-butene multiple interactionsEXP 6480464[indole-3-carbinol co-treated with 1-cyano-2-hydroxy-3-butene] results in increased expression of GSTA2 mRNACTDPMID:11446830
Gsta2Rat1-Cyano-2-hydroxy-3-butene increases expressionEXP 64804641-cyano-2-hydroxy-3-butene results in increased expression of GSTA2 mRNACTDPMID:11446830
Gsta2Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of GSTA2 mRNACTDPMID:12883083
Gsta2Rat1-naphthyl isothiocyanate multiple interactionsISOGsta2 (Mus musculus)6480464[1-Naphthylisothiocyanate co-treated with Uric Acid] results in increased expression of GSTA2 mRNA more ...CTDPMID:15913567 and PMID:33749747
Gsta2Rat1-naphthyl isothiocyanate increases expressionISOGsta2 (Mus musculus)64804641-Naphthylisothiocyanate results in increased expression of GSTA2 mRNACTDPMID:15913567 and PMID:33749747
Gsta2Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of GSTA2 mRNACTDPMID:23135549
Gsta2Rat17alpha-ethynylestradiol multiple interactionsISOGsta2 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of GSTA2 mRNACTDPMID:17942748
Gsta2Rat17alpha-ethynylestradiol affects expressionISOGsta2 (Mus musculus)6480464Ethinyl Estradiol affects the expression of GSTA2 mRNACTDPMID:17555576
Gsta2Rat17alpha-ethynylestradiol increases expressionISOGsta2 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of GSTA2 mRNACTDPMID:17942748
Gsta2Rat17alpha-ethynylestradiol multiple interactionsEXP 6480464Cadmium Chloride inhibits the reaction [Ethinyl Estradiol results in decreased expression of GSTA2 mRNA]CTDPMID:23135549

1 to 20 of 450 rows

Biological Process
1 to 11 of 11 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta2Ratcellular oxidant detoxification involved_inIEAGO:00046021600115GO_REF:0000108GOCGO_REF:0000108
Gsta2Ratcellular oxidant detoxification involved_inIEAGO:00046011600115GO_REF:0000108GOCGO_REF:0000108
Gsta2Ratepithelial cell differentiation involved_inISOGSTA2 (Homo sapiens)1624291 PMID:21492153RGDPMID:21492153
Gsta2Ratglutathione derivative biosynthetic process involved_inISSUniProtKB:P082631600115GO_REF:0000024UniProtGO_REF:0000024
Gsta2Ratglutathione metabolic process involved_inIBAFB:FBgn0010226 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsta2Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Gsta2Ratprostaglandin metabolic process involved_inISSUniProtKB:P082631600115GO_REF:0000024UniProtGO_REF:0000024
Gsta2Ratresponse to bacterium acts_upstream_of_or_withinISOGsta2 (Mus musculus)1624291 PMID:23012479RGDPMID:23012479
Gsta2Ratresponse to stilbenoid involved_inISOGsta2 (Mus musculus)1624291 PMID:17086191RGDPMID:17086191
Gsta2Ratxenobiotic catabolic process involved_inIDA 12793043PMID:17112229CAFA 
Gsta2Ratxenobiotic metabolic process involved_inIBAPANTHER:PTN002480403 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
1 to 11 of 11 rows

Cellular Component

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta2Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gsta2Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gsta2Ratcytosol located_inISOGSTA2 (Homo sapiens)1624291 RGDGO_REF:0000052
Gsta2Ratcytosol located_inISOGsta2 (Mus musculus)1624291 PMID:15100242RGDPMID:15100242
Gsta2Ratcytosol located_inIDA 12793043PMID:17112229CAFA 
Gsta2Ratcytosol is_active_inIBAMGI:1095417 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsta2Ratmitochondrion located_inISOGsta2 (Mus musculus)1624291 PMID:15100242RGDPMID:15100242

Molecular Function
1 to 18 of 18 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta2Ratdinitrosyl-iron complex binding  IPIdinitrosyl-iron complex1641938 RGD 
Gsta2Ratglutathione binding enablesIDA 12793030PMID:15152091CAFA 
Gsta2Ratglutathione binding enablesIDA 12793023PMID:10751412CAFA 
Gsta2Ratglutathione binding enablesIDA 12793043PMID:17112229CAFA 
Gsta2Ratglutathione transferase activity enablesIDA 12793030PMID:15152091CAFA 
Gsta2Ratglutathione transferase activity enablesISOGsta2 (Mus musculus)1624291 PMID:9606968RGDPMID:9606968
Gsta2Ratglutathione transferase activity enablesIBAFB:FBgn0010226 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsta2Ratglutathione transferase activity enablesIDA 12793023PMID:10751412CAFA 
Gsta2Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gsta2Ratglutathione transferase activity enablesIEAInterPro:IPR0030801600115GO_REF:0000002InterProGO_REF:0000002
Gsta2Ratglutathione transferase activity enablesIDA 12793043PMID:17112229CAFA 
Gsta2Ratisomerase activity enablesIEAUniProtKB-KW:KW-04131600115GO_REF:0000043UniProtGO_REF:0000043
Gsta2Ratoxidoreductase activity enablesIEAUniProtKB-KW:KW-05601600115GO_REF:0000043UniProtGO_REF:0000043
Gsta2Ratperoxidase activity enablesIEAUniProtKB-KW:KW-05751600115GO_REF:0000043UniProtGO_REF:0000043
Gsta2Ratprotein binding enablesISOGSTA2 (Homo sapiens)1624291UniProtKB:O15217 more ...RGDPMID:25416956 more ...
Gsta2Ratprotein homodimerization activity enablesIDA 12793030PMID:15152091CAFA 
Gsta2Ratsteroid Delta-isomerase activity enablesISSUniProtKB:P082631600115GO_REF:0000024UniProtGO_REF:0000024
Gsta2Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
1 to 18 of 18 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta2Ratglutathione conjugation pathway  ISS 1358120 RGD 
Gsta2Ratglutathione conjugation pathway  IDA 1641938 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta2Ratglutathione metabolic pathway  IEA 6907045 KEGGrno:00480
Gsta2Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00980
Gsta2Ratphase I biotransformation pathway via cytochrome P450  IEA 6907045 KEGGrno:00982

1 to 20 of 24 rows
#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1. Hayes JD, etal., J Biol Chem 1994 Aug 12;269(32):20707-17.
4. Rat glutathione S-transferase. Cloning of double-stranded cDNA and induction of its mRNA. Kalinyak JE and Taylor JM, J Biol Chem 1982 Jan 10;257(1):523-30.
5. Essential role of phosphatidylinositol 3-kinase-dependent CCAAT/enhancer binding protein beta activation in the induction of glutathione S-transferase by oltipraz. Kang KW, etal., J Natl Cancer Inst 2003 Jan 1;95(1):53-66.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo. Koen YM, etal., Chem Res Toxicol. 2006 Nov;19(11):1426-34.
8. The nucleotide sequence of a rat liver glutathione S-transferase subunit cDNA clone. Lai HC, etal., J Biol Chem 1984 May 10;259(9):5536-42.
9. Age, gender and region-specific differences in drug metabolising enzymes in rat ocular tissues. Nakamura K, etal., Exp Eye Res. 2005 Dec;81(6):710-5. Epub 2005 Jun 20.
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. The catalytic Tyr-9 of glutathione S-transferase A1-1 controls the dynamics of the C terminus. Nieslanik BS and Atkins WM, J Biol Chem. 2000 Jun 9;275(23):17447-51.
12. Expression and sequence analysis of rat liver glutathione S-transferase genes. Pickett CB, etal., Adv Exp Med Biol 1986;197:185-93.
13. Rat liver glutathione S-transferases. Complete nucleotide sequence of a glutathione S-transferase mRNA and the regulation of the Ya, Yb, and Yc mRNAs by 3-methylcholanthrene and phenobarbital. Pickett CB, etal., J Biol Chem 1984 Apr 25;259(8):5182-8.
14. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope. Stella L, etal., J Biol Chem. 2007 Mar 2;282(9):6372-9. Epub 2006 Dec 30.
18. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
1 to 20 of 24 rows
PMID:2421763   PMID:2645828   PMID:2985614   PMID:3025841   PMID:6688942   PMID:8144363   PMID:15035604   PMID:15319326   PMID:15489334   PMID:15870285   PMID:17086191   PMID:17786629  
PMID:21492153   PMID:21905055   PMID:23012479  



Gsta2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8888,064,829 - 88,077,168 (-)NCBIGRCr8
mRatBN7.2879,184,535 - 79,196,827 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl879,184,322 - 79,196,798 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx884,705,976 - 84,719,310 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0882,982,644 - 82,995,978 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0880,805,340 - 80,818,674 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0885,640,081 - 85,645,621 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0885,197,052 - 85,202,588 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4883,299,249 - 83,312,958 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1883,318,303 - 83,332,012 (-)NCBI
Celera878,931,925 - 78,944,156 (-)NCBICelera
Cytogenetic Map8q31NCBI
GSTA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,750,087 - 52,763,475 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,750,087 - 52,763,475 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,614,885 - 52,628,273 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,723,140 - 52,736,283 (-)NCBINCBI36Build 36hg18NCBI36
Build 34652,723,139 - 52,736,283NCBI
Celera654,275,978 - 54,289,456 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,446,103 - 52,459,571 (-)NCBIHuRef
CHM1_1652,617,113 - 52,630,562 (-)NCBICHM1_1
T2T-CHM13v2.0652,588,869 - 52,602,258 (-)NCBIT2T-CHM13v2.0
Gsta2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39978,238,300 - 78,254,474 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl978,238,300 - 78,263,070 (-)EnsemblGRCm39 Ensembl
GRCm38978,331,018 - 78,347,192 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl978,331,018 - 78,355,788 (-)EnsemblGRCm38mm10GRCm38
MGSCv37978,178,827 - 78,194,952 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36978,116,704 - 78,132,829 (-)NCBIMGSCv36mm8
Celera975,504,493 - 75,521,021 (-)NCBICelera
Cytogenetic Map9E1NCBI
cM Map943.65NCBI
LOC481841
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11220,319,222 - 20,338,681 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1220,215,030 - 20,233,827 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01220,817,395 - 20,835,810 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.11220,323,240 - 20,341,615 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01220,426,863 - 20,445,653 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01220,565,510 - 20,584,316 (-)NCBIUU_Cfam_GSD_1.0

.

.
Variants in Gsta2
108 total Variants

Predicted Target Of
Summary Value
Count of predictions:347
Count of miRNA genes:195
Interacting mature miRNAs:225
Transcripts:ENSRNOT00000032185, ENSRNOT00000044944
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 57 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85009524982460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat

1 to 10 of 57 rows
PMC133753P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0885,110,551 - 85,110,671NCBIRnor5.0
Rnor_5.0885,246,703 - 85,246,823NCBIRnor5.0
RGSC_v3.4883,313,599 - 83,313,718UniSTSRGSC3.4
Celera878,849,420 - 78,849,539UniSTS
Cytogenetic Map8q31UniSTS
RH143684  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2879,112,440 - 79,112,544 (-)MAPPERmRatBN7.2
mRatBN7.2879,112,440 - 79,112,544 (+)MAPPERmRatBN7.2
mRatBN7.2879,189,476 - 79,189,580 (-)MAPPERmRatBN7.2
mRatBN7.2879,189,476 - 79,189,580 (+)MAPPERmRatBN7.2
Rnor_6.0885,644,665 - 85,644,768NCBIRnor6.0
Rnor_6.0885,559,883 - 85,559,986NCBIRnor6.0
Rnor_5.0885,117,591 - 85,117,694UniSTSRnor5.0
Rnor_5.0885,201,632 - 85,201,735UniSTSRnor5.0
RGSC_v3.4883,206,967 - 83,207,070UniSTSRGSC3.4
RGSC_v3.4883,304,715 - 83,304,818UniSTSRGSC3.4
Celera878,936,867 - 78,936,970UniSTS
Celera878,857,199 - 78,857,302UniSTS
RH 3.4 Map8927.59UniSTS
Cytogenetic Map8q31UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 9 32 78 76 55 13 55 6 143 35 16 40 43 21



Ensembl Acc Id: ENSRNOT00000032185   ⟹   ENSRNOP00000037786
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,184,322 - 79,196,798 (-)Ensembl
Rnor_6.0 Ensembl885,640,055 - 85,645,718 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106378   ⟹   ENSRNOP00000091487
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl879,184,322 - 79,191,537 (-)Ensembl
RefSeq Acc Id: NM_017013   ⟹   NP_058709
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8888,064,829 - 88,077,092 (-)NCBI
mRatBN7.2879,184,535 - 79,196,798 (-)NCBI
Rnor_5.0885,197,052 - 85,202,588 (-)NCBI
RGSC_v3.4883,299,249 - 83,312,958 (-)RGD
Celera878,931,925 - 78,944,156 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080797   ⟹   XP_038936725
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8888,064,829 - 88,077,168 (-)NCBI
mRatBN7.2879,184,563 - 79,196,827 (-)NCBI
RefSeq Acc Id: NP_058709   ⟸   NM_017013
- UniProtKB: Q63715 (UniProtKB/Swiss-Prot),   P04903 (UniProtKB/Swiss-Prot),   Q6AZ72 (UniProtKB/Swiss-Prot),   P00502 (UniProtKB/Swiss-Prot),   B6DYP7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038936725   ⟸   XM_039080797
- Peptide Label: isoform X1
- UniProtKB: Q63715 (UniProtKB/Swiss-Prot),   P04903 (UniProtKB/Swiss-Prot),   P00502 (UniProtKB/Swiss-Prot),   Q6AZ72 (UniProtKB/Swiss-Prot),   B6DYP7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091487   ⟸   ENSRNOT00000106378
Ensembl Acc Id: ENSRNOP00000037786   ⟸   ENSRNOT00000032185
GST C-terminal   GST N-terminal

Name Modeler Protein Id AA Range Protein Structure
AF-P00502-F1-model_v2 AlphaFold P00502 1-222 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-29765 BioCyc
Ensembl Genes ENSRNOG00000000201 ENTREZGENE
  ENSRNOG00000029861 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000032185 ENTREZGENE
  ENSRNOT00000032185.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7128611 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_alpha UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:24422 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93118 IMAGE-MGC_LOAD
NCBI Gene 24422 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE-RELATED UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PharmGKB GSTA2 RGD
PhenoGen Gsta2 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000000201 RatGTEx
  ENSRNOG00000029861 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
TIGR TC239508
UniProt A0A8I6GJP0_RAT UniProtKB/TrEMBL
  B6DYP7 ENTREZGENE, UniProtKB/TrEMBL
  F7F2H5_RAT UniProtKB/TrEMBL
  GSTA1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P04903 ENTREZGENE
  Q63715 ENTREZGENE
  Q6AZ72 ENTREZGENE
UniProt Secondary Q6AZ72 UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-10-22 Gsta2  glutathione S-transferase alpha 2  Gsta2  glutathione S-transferase A2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Gsta2  glutathione S-transferase A2  Gsta2  glutathione S-transferase, alpha 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Gsta2  glutathione S-transferase, alpha 2  Gsta2  glutathione-S-transferase, alpha type2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Gsta2  glutathione-S-transferase, alpha type2      Name updated 70584 APPROVED

Note Type Note Reference
gene_product member of the alpha class of glutathione S-transferases 633010