Gsta1 (glutathione S-transferase alpha 1) - Rat Genome Database

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Gene: Gsta1 (glutathione S-transferase alpha 1) Rattus norvegicus
Analyze
Symbol: Gsta1
Name: glutathione S-transferase alpha 1
RGD ID: 2753
Description: Enables dinitrosyl-iron complex binding activity; glutathione binding activity; and glutathione transferase activity. Involved in response to nutrient levels and xenobiotic catabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in asthma and ovarian cancer. Orthologous to human GSTA1 (glutathione S-transferase alpha 1); PARTICIPATES IN glutathione conjugation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 1-chloro-2,4-dinitrobenzene; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase A1; glutathione S-transferase A3; glutathione S-transferase A3 subunit; glutathione S-transferase A5; glutathione S-transferase alpha 3; glutathione S-transferase alpha-3; glutathione S-transferase Yc-1; glutathione S-transferase Yc1 subunit; glutathione S-transferase, alpha 1; glutathione transferase A3 subunit; Glutathione-S-transferase alpha type (Ya); Glutathione-S-transferase, alpha type (Ya); GST 2-2; GST A3-3; GST AA; GST Yc1; Gsta3; Gsta5; LOC108348061; MGC112704; Yc1
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8931,199,887 - 31,216,606 (-)NCBIGRCr8
GRCr8 Ensembl931,199,888 - 31,211,528 (-)EnsemblGRCr8 Ensembl
mRatBN7.2923,703,476 - 23,720,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,703,477 - 23,720,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx932,196,752 - 32,213,351 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0937,317,434 - 37,334,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,632,677 - 35,649,276 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0927,366,404 - 27,381,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,368,272 - 27,452,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0926,283,550 - 26,300,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,051,501 - 20,068,146 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera921,278,681 - 21,295,265 (-)NCBICelera
RGSC_v3.1920,048,823 - 20,065,988 (-)NCBI
Cytogenetic Map9q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta1Ratasthma susceptibilityISORDG:13492005490988DNA:polymorphism:promoter: -69C>T (human)RGD 
Gsta1Ratovarian cancer disease_progressionISOGSTA1 (Homo sapiens)5688741DNA:polymorphism:: -69C>T(human)RGD 
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta1Ratacute kidney failure  ISOGSTA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28885000
Gsta1RatChemical and Drug Induced Liver Injury  ISOGSTA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28412881
Gsta1RatDrug-Related Side Effects and Adverse Reactions  ISOGSTA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:28885000
Gsta1Ratmetabolic dysfunction-associated steatotic liver disease  ISOGSTA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:23643483
Gsta1RatMyocardial Ischemia  ISOGSTA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16214533
Gsta1RatProstatic Neoplasms  ISOGSTA1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15616829

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Object Symbol
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Source
Original Reference(s)
Gsta1Rat(+)-artemisinin decreases activityISOGSTA1 (Homo sapiens)6480464artemisinin results in decreased activity of GSTA1 proteinCTDPMID:11807801
Gsta1Rat1,2-Dibromo-3-chloropropane affects metabolic processingISOGSTA1 (Homo sapiens)6480464GSTA1 protein affects the metabolism of 1,2-dibromo-3-chloropropaneCTDPMID:8242859
Gsta1Rat1,2-Dibromo-3-chloropropane increases response to substanceISOGSTA1 (Homo sapiens)6480464GSTA1 protein results in increased susceptibility to 1,2-dibromo-3-chloropropaneCTDPMID:8242859
Gsta1Rat1,2-dichloroethane multiple interactionsISOGSTA1 (Homo sapiens)6480464GSTA1 protein affects the metabolism of and results in increased activity of and results in more ...CTDPMID:11673082
Gsta1Rat1,2-dimethylhydrazine decreases expressionEXP 64804641,2-Dimethylhydrazine results in decreased expression of GSTA1 mRNACTDPMID:32387197
Gsta1Rat1-chloro-2,4-dinitrobenzene increases expressionEXP 6480464Dinitrochlorobenzene results in increased expression of GSTA1 proteinCTDPMID:9794801
Gsta1Rat1-chloro-2,4-dinitrobenzene increases metabolic processingISOGSTA1 (Homo sapiens)6480464GSTA1 protein results in increased metabolism of DinitrochlorobenzeneCTDPMID:3138230
Gsta1Rat1-chloro-2,4-dinitrobenzene multiple interactionsISOGSTA1 (Homo sapiens)6480464[GSTA1 protein binds to GSTA1 protein] which affects the metabolism of Dinitrochlorobenzene; [GSTA1 protein binds more ...CTDPMID:11851347|PMID:12147362|PMID:14690442
Gsta1Rat1-naphthyl isothiocyanate increases expressionEXP 64804641-Naphthylisothiocyanate results in increased expression of GSTA1 mRNACTDPMID:20551477
Gsta1Rat1-naphthyl isothiocyanate multiple interactionsISOGSTA1 (Homo sapiens)6480464[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of GSTA1 mRNACTDPMID:27344345
Gsta1Rat13-oxo-9,11-octadecadienoic acid affects metabolic processingISOGSTA1 (Homo sapiens)6480464GSTA1 protein affects the metabolism of 13-oxo-9,11-octadecadienoic acidCTDPMID:12031293
Gsta1Rat17-beta-Estradiol-3,17-beta-sulfate multiple interactionsISOGSTA1 (Homo sapiens)6480464estradiol 3,17-disulfate binds to and results in decreased activity of GSTA1 proteinCTDPMID:12206662
Gsta1Rat17alpha-ethynylestradiol decreases expressionEXP 6480464Ethinyl Estradiol results in decreased expression of GSTA1 mRNACTDPMID:12655037|PMID:15834898
Gsta1Rat17beta-estradiol decreases expressionISOGSTA1 (Homo sapiens)6480464Estradiol results in decreased expression of GSTA1 mRNACTDPMID:23019147
Gsta1Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOGSTA1 (Homo sapiens)6480464[Tetrachlorodibenzodioxin co-treated with Rifampin] results in increased expression of GSTA1 mRNACTDPMID:29162470
Gsta1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of GSTA1 mRNACTDPMID:34747641
Gsta1Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOGSTA1 (Homo sapiens)6480464Tetrachlorodibenzodioxin results in decreased expression of GSTA1 mRNACTDPMID:20106945|PMID:21632981|PMID:23669205|PMID:26238291
Gsta1Rat2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine multiple interactionsISOGSTA1 (Homo sapiens)6480464GSTA1 protein affects the metabolism of and results in decreased activity of 2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridineCTDPMID:11535243|PMID:15797627|PMID:8069858
Gsta1Rat2-Acetoxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine increases response to substanceISOGSTA1 (Homo sapiens)6480464GSTA1 protein polymorphism results in increased susceptibility to 2-(acetoxyamino)-1-methyl-6-phenylimidazo(4,5-b)pyridineCTDPMID:11535243
Gsta1Rat2-allylphenol decreases activityISOGSTA1 (Homo sapiens)64804642-allylphenol results in decreased activity of GSTA1 proteinCTDPMID:8620581

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Biological Process
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Object Symbol
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Term
Qualifier
Evidence
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Reference
Notes
Source
Original Reference(s)
Gsta1Ratepithelial cell differentiation involved_inISOGSTA1 (Homo sapiens)1624291 PMID:21492153RGDPMID:21492153
Gsta1Ratglutathione derivative biosynthetic process involved_inISOGSTA1 (Homo sapiens)1624291 PMID:9084911RGDPMID:9084911
Gsta1Ratglutathione metabolic process involved_inISOGSTA1 (Homo sapiens)1624291 PMID:20606271RGDPMID:20606271
Gsta1Ratglutathione metabolic process involved_inIBAFB:FBgn0010226|MGI:95864|MGI:95865|PANTHER:PTN000170884|RGD:2755|RGD:2756|UniProtKB:O15217|UniProtKB:P08263|UniProtKB:P09211|UniProtKB:P09488|UniProtKB:P21266|UniProtKB:P28161|UniProtKB:P46439|UniProtKB:Q03013|UniProtKB:Q8ILQ7|WB:WBGene00001752|WB:WBGene000017581600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsta1Ratglutathione metabolic process acts_upstream_of_or_withinISOGSTA1 (Homo sapiens)1624291 PMID:11851347RGDPMID:11851347
Gsta1Ratlinoleic acid metabolic process involved_inISOGSTA1 (Homo sapiens)1624291 PMID:16624487RGDPMID:16624487
Gsta1Ratlipid metabolic process involved_inIEAUniProtKB-KW:KW-04431600115GO_REF:0000043UniProtGO_REF:0000043
Gsta1Ratprostaglandin metabolic process involved_inISOGSTA1 (Homo sapiens)1624291 PMID:9084911RGDPMID:9084911
Gsta1Ratresponse to nutrient levels  IEP 2316562 RGD 
Gsta1Ratresponse to xenobiotic stimulus  NAS 633003 RGD 
Gsta1Ratxenobiotic catabolic process involved_inIDA 12793043PMID:17112229CAFA 
Gsta1Ratxenobiotic metabolic process involved_inIBAPANTHER:PTN002480403|RGD:1593189|RGD:2753|RGD:2754|UniProtKB:O152171600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component

  
Object Symbol
Species
Term
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Evidence
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Reference
Notes
Source
Original Reference(s)
Gsta1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Gsta1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Gsta1Ratcytosol located_inIDA 12793043PMID:17112229CAFA 
Gsta1Ratcytosol is_active_inIBAMGI:1095417|MGI:95856|MGI:95863|PANTHER:PTN000170932|RGD:1593189|RGD:2753|RGD:2754|UniProtKB:P08263|UniProtKB:P09210|UniProtKB:Q16772|UniProtKB:Q7RTV21600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsta1Ratcytosol located_inISOGSTA1 (Homo sapiens)1624291 RGDGO_REF:0000052

Molecular Function
1 to 12 of 12 rows

  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta1Ratdinitrosyl-iron complex binding  IDA 1641938 RGD 
Gsta1Ratfatty acid binding enablesISOGSTA1 (Homo sapiens)1624291CHEBI:72639 PMID:16624487RGDPMID:16624487
Gsta1Ratglutathione binding enablesIDA 12793043PMID:17112229CAFA 
Gsta1Ratglutathione peroxidase activity enablesISOGSTA1 (Homo sapiens)1624291 PMID:16624487RGDPMID:16624487
Gsta1Ratglutathione transferase activity enablesISOGSTA1 (Homo sapiens)1624291 PMID:11851347, PMID:20606271, PMID:9084911RGDPMID:11851347|PMID:20606271|PMID:9084911
Gsta1Ratglutathione transferase activity enablesIBAFB:FBgn0010226|MGI:1095417|MGI:1309466|MGI:95856|MGI:95861|MGI:95862|MGI:95863|MGI:95864|MGI:95865|PANTHER:PTN000170884|RGD:1593189|RGD:2753|RGD:2754|RGD:2755|RGD:2756|RGD:61964|UniProtKB:C8V321|UniProtKB:O15217|UniProtKB:P08263|UniProtKB:P09211|UniProtKB:P09488|UniProtKB:P21266|UniProtKB:P28161|UniProtKB:P46439|UniProtKB:Q03013|UniProtKB:Q8ILQ7|WB:WBGene00001749|WB:WBGene00001752|WB:WBGene00001758|ZFIN:ZDB-GENE-020806-4|ZFIN:ZDB-GENE-030911-2|ZFIN:ZDB-GENE-050309-24|ZFIN:ZDB-GENE-050601-1|dictyBase:DDB_G02726321600115GO_REF:0000033GO_CentralGO_REF:0000033
Gsta1Ratglutathione transferase activity enablesIEAInterPro:IPR0030801600115GO_REF:0000002InterProGO_REF:0000002
Gsta1Ratglutathione transferase activity enablesIEAEC:2.5.1.181600115GO_REF:0000003UniProtGO_REF:0000003
Gsta1Ratglutathione transferase activity enablesIDA 12793043PMID:17112229CAFA 
Gsta1Ratprotein binding enablesISOGSTA1 (Homo sapiens)1624291UniProtKB:Q9BX51 PMID:28514442, PMID:33961781RGDPMID:28514442|PMID:33961781
Gsta1Ratsteroid Delta-isomerase activity enablesISOGSTA1 (Homo sapiens)1624291 PMID:11152686RGDPMID:11152686
Gsta1Rattransferase activity enablesIEAUniProtKB-KW:KW-08081600115GO_REF:0000043UniProtGO_REF:0000043
1 to 12 of 12 rows

RGD Manual Annotations


  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Gsta1Ratglutathione conjugation pathway  ISS 1358120 RGD 
Gsta1Ratglutathione conjugation pathway  IDA 1641938 RGD 

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#
Reference Title
Reference Citation
1. Rat ligandin mRNA molecular cloning and sequencing. Daniel V, etal., Arch Biochem Biophys 1983 Nov;227(1):266-71.
2. Genomic cloning and characterization of the rat glutathione S-transferase-A3-subunit gene. Fotouhi-Ardakani N and Batist G, Biochem J 1999 May 1;339 ( Pt 3):685-93.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1. Hayes JD, etal., J Biol Chem 1994 Aug 12;269(32):20707-17.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Genetic polymorphisms and the efficacy and toxicity of cisplatin-based chemotherapy in ovarian cancer patients. Khrunin AV, etal., Pharmacogenomics J. 2010 Feb;10(1):54-61. Epub 2009 Sep 29.
7. Mapping of glutathione transferase (GST) genes in the rat. Klinga-Levan K, etal., Hereditas 1993;119(3):285-96.
8. Site-specific arylation of rat glutathione s-transferase A1 and A2 by bromobenzene metabolites in vivo. Koen YM, etal., Chem Res Toxicol. 2006 Nov;19(11):1426-34.
9. Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways. Korashy HM, etal., Anticancer Res. 2017 Sep;37(9):4899-4909. doi: 10.21873/anticanres.11899.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Age, gender and region-specific differences in drug metabolising enzymes in rat ocular tissues. Nakamura K, etal., Exp Eye Res. 2005 Dec;81(6):710-5. Epub 2005 Jun 20.
12. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
13. Isoenzyme-specific up-regulation of glutathione transferase and aldo-keto reductase mRNA expression by dietary quercetin in rat liver. Odbayar TO, etal., Mol Cell Biochem. 2009 May;325(1-2):121-30. Epub 2009 Feb 4.
14. GSTA1, GSTO1 and GSTO2 gene polymorphisms in Italian asthma patients. Polimanti R, etal., Clin Exp Pharmacol Physiol. 2010 Aug;37(8):870-2. Epub 2010 Mar 30.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Electrostatic association of glutathione transferase to the nuclear membrane. Evidence of an enzyme defense barrier at the nuclear envelope. Stella L, etal., J Biol Chem. 2007 Mar 2;282(9):6372-9. Epub 2006 Dec 30.
18. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
19. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
20. Identification and characterization of novel rat and human gonad-specific organic anion transporters. Suzuki T, etal., Mol Endocrinol 2003 Jul;17(7):1203-15. Epub 2003 Apr 3.
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PMID:1953636   PMID:2186703   PMID:6325423   PMID:9084911   PMID:10677856   PMID:11152686   PMID:11851347   PMID:15035604   PMID:15489334   PMID:16624487   PMID:19056867   PMID:20606271  
PMID:21492153   PMID:23376485   PMID:23533145  



Gsta1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8931,199,887 - 31,216,606 (-)NCBIGRCr8
GRCr8 Ensembl931,199,888 - 31,211,528 (-)EnsemblGRCr8 Ensembl
mRatBN7.2923,703,476 - 23,720,121 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl923,703,477 - 23,720,121 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx932,196,752 - 32,213,351 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0937,317,434 - 37,334,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0935,632,677 - 35,649,276 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0927,366,404 - 27,381,004 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl927,368,272 - 27,452,902 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0926,283,550 - 26,300,195 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4920,051,501 - 20,068,146 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera921,278,681 - 21,295,265 (-)NCBICelera
RGSC_v3.1920,048,823 - 20,065,988 (-)NCBI
Cytogenetic Map9q13NCBI
GSTA1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38652,791,371 - 52,803,816 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl652,791,371 - 52,803,860 (-)EnsemblGRCh38hg38GRCh38
GRCh37652,656,169 - 52,668,614 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36652,764,347 - 52,776,616 (-)NCBINCBI36Build 36hg18NCBI36
Build 34652,764,347 - 52,776,616NCBI
Celera654,317,257 - 54,329,719 (-)NCBICelera
Cytogenetic Map6p12.2NCBI
HuRef652,486,923 - 52,499,385 (-)NCBIHuRef
CHM1_1652,658,375 - 52,670,789 (-)NCBICHM1_1
T2T-CHM13v2.0652,630,148 - 52,642,586 (-)NCBIT2T-CHM13v2.0

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Variants in Gsta1
92 total Variants

Predicted Target Of
Summary Value
Count of predictions:21
Count of miRNA genes:21
Interacting mature miRNAs:21
Transcripts:ENSRNOT00000018325
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 22 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631211Bw4Body weight QTL45.31retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)9510982650109826Rat
2303559Gluco54Glucose level QTL 542blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)9125408446254084Rat
7411609Foco16Food consumption QTL 1625.60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)9895256053952560Rat
631680Cm11Cardiac mass QTL 113.10.00089heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)92043051965430519Rat
70186Niddm26Non-insulin dependent diabetes mellitus QTL 263.87blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)92207116986369743Rat
9589055Scfw5Subcutaneous fat weight QTL 55.550.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)9137999212Rat
1641911Alcrsp13Alcohol response QTL 13response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)9143718459Rat
1354650Despr5Despair related QTL 54.010.0017locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)9125408446254084Rat
1300124Cm4Cardiac mass QTL 43.55heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)9140594091Rat
61425Cia15Collagen induced arthritis QTL 154.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)9510982642921101Rat

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alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 47 107 91 90 59 25 59 6 216 95 87 45 60 31


1 to 30 of 31 rows
RefSeq Transcripts NM_031509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063266628 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC095904 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF067442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF111160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF127460 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF146746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ179398 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211002 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213952 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218508 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219165 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219564 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226984 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229239 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01932 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S72505 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 31 rows

Ensembl Acc Id: ENSRNOT00000018325   ⟹   ENSRNOP00000018325
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl931,199,888 - 31,211,528 (-)Ensembl
mRatBN7.2 Ensembl923,703,477 - 23,720,121 (-)Ensembl
Rnor_6.0 Ensembl927,436,258 - 27,452,902 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000077372   ⟹   ENSRNOP00000068639
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl923,705,078 - 23,720,121 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000085195   ⟹   ENSRNOP00000069606
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl927,368,272 - 27,447,877 (-)Ensembl
RefSeq Acc Id: NM_031509   ⟹   NP_113697
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,199,887 - 31,216,532 (-)NCBI
mRatBN7.2923,703,476 - 23,720,121 (-)NCBI
Rnor_6.0927,366,404 - 27,381,004 (-)NCBI
Rnor_5.0926,283,550 - 26,300,195 (-)NCBI
RGSC_v3.4920,051,501 - 20,068,146 (-)RGD
Celera921,278,681 - 21,295,265 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063266628   ⟹   XP_063122698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8931,199,890 - 31,216,606 (-)NCBI
RefSeq Acc Id: NP_113697   ⟸   NM_031509
- UniProtKB: Q6LD92 (UniProtKB/Swiss-Prot),   P04904 (UniProtKB/Swiss-Prot),   B6DYP8 (UniProtKB/TrEMBL),   Q9JLX3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000018325   ⟸   ENSRNOT00000018325
Ensembl Acc Id: ENSRNOP00000069606   ⟸   ENSRNOT00000085195
Ensembl Acc Id: ENSRNOP00000068639   ⟸   ENSRNOT00000077372
RefSeq Acc Id: XP_063122698   ⟸   XM_063266628
- Peptide Label: isoform X1
- UniProtKB: A0A0G2JTB1 (UniProtKB/TrEMBL)
GST C-terminal   GST N-terminal


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 40 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-28002 BioCyc
Ensembl Genes ENSRNOG00000013484 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000018325 ENTREZGENE
  ENSRNOT00000018325.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot
  Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6922234 IMAGE-MGC_LOAD
  IMAGE:7322480 IMAGE-MGC_LOAD
  IMAGE:7324340 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot
  Glutathione_S-Trfase UniProtKB/Swiss-Prot
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot
  GST_alpha UniProtKB/Swiss-Prot
  GST_C UniProtKB/Swiss-Prot
  GST_superfamily UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:24421 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108659 IMAGE-MGC_LOAD
  MGC:112704 IMAGE-MGC_LOAD
  MGC:72773 IMAGE-MGC_LOAD
NCBI Gene 24421 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE UniProtKB/Swiss-Prot
  GLUTATHIONE S-TRANSFERASE A2 UniProtKB/Swiss-Prot
Pfam GST_C UniProtKB/Swiss-Prot
  GST_N UniProtKB/Swiss-Prot
PharmGKB GSTA1 RGD
PhenoGen Gsta1 PhenoGen
PRINTS GSTRNSFRASEA UniProtKB/Swiss-Prot
PROSITE GST_CTER UniProtKB/Swiss-Prot
  GST_NTER UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000013484 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot
  SSF52833 UniProtKB/Swiss-Prot
UniProt A0A0G2JTB1 ENTREZGENE, UniProtKB/TrEMBL
  B6DYP8 ENTREZGENE, UniProtKB/TrEMBL
  GSTA3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q6LD92 ENTREZGENE
  Q9JLX3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q6LD92 UniProtKB/Swiss-Prot
1 to 40 of 40 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Gsta1  glutathione S-transferase alpha 1  LOC108348061  glutathione S-transferase alpha-3  Data merged from RGD:11504935 737654 PROVISIONAL
2016-08-02 LOC108348061  glutathione S-transferase alpha-3      Symbol and Name status set to provisional 70820 PROVISIONAL
2009-10-22 Gsta1  glutathione S-transferase alpha 1  Gsta1  glutathione S-transferase A1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Gsta1  glutathione S-transferase A1  Gsta1  glutathione S-transferase, alpha 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Gsta1  glutathione S-transferase, alpha 1  Gsta3  glutathione S-transferase A3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-11-17 Gsta3  glutathione S-transferase A3      Symbol and Name updated 1299863 APPROVED
2004-09-10 Gsta5  glutathione S-transferase A5  Gsta1  glutathione S-transferase, alpha 1   Symbol and Name updated 1299863 APPROVED
2002-11-06 Gsta1  glutathione S-transferase, alpha 1     Glutathione-S-transferase, alpha type (Ya)  Name updated 625702 APPROVED
2002-06-10 Gsta1  Glutathione-S-transferase, alpha type (Ya)      Symbol and Name status set to approved 70586 APPROVED

Note Type Note Reference
gene_expression expressed in liver and fibroblast cells 70479
gene_process functions in converting fat soluble chemicals to water-soluble to inhibit build-up of hydrophobic compounds in adipose 70479
gene_product member of the alpha class of glutathione S-transferases 633003